TDMS Study 05110-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest NAPHTHALENE DATE: 03/06/00
EXPERIMENT: 05110 TEST: 02 TIME: 11:08:58
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-55392 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 52904C
PATHOLOGIST: GRUMBEIN, SONDRA CAS: 91-20-3
------------------------------------------------------------------------------------------------------------------------------------
FINAL#2, CORE STUDY RATS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest NAPHTHALENE DATE: 03/06/00
EXPERIMENT: 05110 TEST: 02 TIME: 11:08:58
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55392 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 52904C
PATHOLOGIST: GRUMBEIN, SONDRA CAS: 91-20-3
NAPHTHALENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 460 460 469 502 516 572 615 615 624 634 |
| 639 657 658 660 660 677 678 692 695 703 |
| 708 709 713 721 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 27 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 390 435 502 505 520 525 551 567 593 600 |
| 615 643 643 643 648 665 677 678 680 681 |
| 681 684 684 695 700 713 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 PPM |
| --------------------- |
| |
| TOTAL 48 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 433 489 523 547 560 563 574 582 600 613 |
| 613 615 630 643 643 650 663 677 681 681 |
| 685 685 707 710 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NAPHTHALENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 60 PPM |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 245 399 419 469 496 526 527 539 552 560 |
| 562 572 575 600 608 624 632 639 657 659 |
| 660 671 685 685 703 707 712 722 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NAPHTHALENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 93.9 89.8 87.8 69.4 49.0 |
| | |
| | |
|10 PPM | 100.0 100.0 100.0 100.0 98.0 95.9 87.8 79.6 67.3 44.9 |
| | |
| | |
|30 PPM | 100.0 100.0 100.0 100.0 100.0 97.9 93.7 81.3 64.6 47.9 |
| | |
| | |
|60 PPM | 100.0 100.0 98.0 98.0 93.9 91.8 83.7 71.4 57.1 42.9 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 10 PPM 30 PPM 60 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 49.0% 44.9% 47.9% 42.9% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.433 P=0.702 P=0.880 P=0.414 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 630.5 616.4 619.8 585.9 |
|NATURAL DEATHS (C) | (17.1) (17.0) (14.6) (20.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 680.7 668.8 674.0 648.9 |
|(STANDARD ERROR) | (11.4) (12.5) (11.2) (15.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NAPHTHALENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 509 519 572 602 604 625 657 657 671 671 |
| 671 676 677 679 684 690 705 707 713 725 |
| 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 440 471 503 509 518 574 577 581 581 587 |
| 602 609 622 625 635 647 663 665 677 677 |
| 677 679 679 699 713 721 723 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 PPM |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 440 440 480 512 581 586 587 587 588 615 |
| 624 630 653 653 660 671 685 699 707 715 |
| 721 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NAPHTHALENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 60 PPM |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 111 429 445 478 482 503 536 547 555 579 |
| 601 617 624 625 625 642 643 656 667 677 |
| 680 684 685 720 722 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NAPHTHALENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 734 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 100.0 100.0 95.9 89.8 83.7 57.1 |
| | |
| | |
|10 PPM | 100.0 100.0 100.0 100.0 100.0 95.9 89.8 77.6 63.3 42.9 |
| | |
| | |
|30 PPM | 100.0 100.0 100.0 100.0 100.0 93.9 91.8 81.6 69.4 57.1 |
| | |
| | |
|60 PPM | 100.0 98.0 98.0 98.0 98.0 89.8 85.7 77.6 63.3 49.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 10 PPM 30 PPM 60 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 57.1% 42.9% 57.1% 49.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.572 P=0.127 P=0.892 P=0.277 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 654.3 620.7 611.1 581.3 |
|NATURAL DEATHS (C) | (13.5) (14.9) (18.5) (25.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 699.9 669.3 681.3 656.1 |
|(STANDARD ERROR) | ( 8.0) (11.7) (11.8) (17.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NAPHTHALENE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
10 PPM = 2
30 PPM = 3
60 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 3 1
| 4 24 32 3
| 4 4 2 11 3 12 3 3
| 4 4121 2 33
P 90 + 4 1 4 331
E | 2 2 31 1
R | 44 2 23 3
C | 4 442 3 22 1 11
E 80 + 44 2 2 11
N | 44 2 1 1
T | 44 3 3
| 4 44 3 221 1
S 70 + 4 4 32 1 1
U | 44 3 2 2
R | 44 3 1 1
V | 4 4 2211
I 60 + 4 4 111
V | 44
A | 4 3 3
L | 2 2311
50 + 4 24211 1
| 42 2 3
| 4 2 2
| 4 4
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 34 obs hidden.
NAPHTHALENE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
10 PPM = 2
30 PPM = 3
60 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 1
| 4 42 2 1 1
| 434 23 223 1 1 1
| 22 3 11
P 90 + 4 4 2 233 1 1
E | 4 4 22 1 1
R | 4 4
C | 44 22 3 1 1
E 80 + 42 2 3 3
N | 22 4 11
T | 2 23 3
| 222 3 3 11
S 70 + 4242 33 11
U | 2 23 31 1
R | 4 4 3 3
V | 4 242 311
I 60 + 444 3131
V | 31 1
A |
L | 24 2 4
50 + 2 224 4
| 22
|
| 2 2
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 24 obs hidden.