TDMS Study 05110-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
NAPHTHALENE
NTP Experiment-Test: 05110-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:12:04
Facility: Northrop Services, Inc.
Chemical CAS #: 91-20-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05110-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:12:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 30 PPM 30 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 75 75 75 75
Scheduled Sacrifice 5 7 6 6
Early Deaths
Dead 8 6 10 7
Moribund 2 1 6 10
Accident 1 1
Survivors
Terminal Sacrifice 59 56 51 50
Dead 1
Accident 1
Missing 3 1 2
Animals Examined Microscopically 69 65 68 67
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (65) (2) (60) (64)
Dilatation 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 2 (3%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%) 1 (2%)
Serosa, Inflammation, Chronic, Multifocal 1 (2%)
Intestine Large, Cecum (66) (1) (60) (64)
Hyperplasia, Focal, Lymphoid 1 (2%) 1 (2%)
Serosa, Inflammation, Chronic, Multifocal 1 (2%)
Intestine Large, Colon (67) (2) (62) (66)
Parasite Metazoan 4 (6%) 3 (5%)
Intestine Small, Duodenum (66) (4) (61) (63)
Hyperplasia, Focal, Lymphoid 1 (25%) 1 (2%)
Intestine Small, Ileum (66) (1) (61) (63)
Amyloid Deposition, Multifocal 1 (2%)
Serosa, Inflammation, Chronic, Multifocal 1 (2%)
Intestine Small, Jejunum (65) (1) (61) (63)
Serosa, Inflammation, Chronic, Multifocal 1 (2%)
Liver (68) (12) (67) (67)
Angiectasis, Focal 1 (1%) 1 (1%)
Basophilic Focus 1 (1%)
Clear Cell Focus 1 (1%)
Cyst 1 (1%)
Focal Cellular Change, Focal 1 (1%)
Hematopoietic Cell Proliferation, Focal 2 (3%)
Hematopoietic Cell Proliferation, Multifocal 5 (7%) 7 (10%) 5 (7%)
Infiltration Cellular, Focal, Lymphocyte 1 (1%) 5 (7%) 7 (10%)
Infiltration Cellular, Multifocal, Lymphocyte 16 (24%) 1 (8%) 16 (24%) 17 (25%)
Inflammation, Chronic, Multifocal 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05110-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:12:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 30 PPM 30 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mineralization, Focal 1 (1%) 1 (1%)
Necrosis, Focal 1 (1%) 2 (3%)
Necrosis, Multifocal 1 (8%) 2 (3%) 1 (1%)
Pigmentation, Focal 1 (1%) 1 (1%)
Bile Duct, Cytoplasmic Alteration, Multifocal 1 (1%)
Hepatocyte, Atrophy, Diffuse 1 (1%)
Mesentery (6) (3) (3)
Infiltration Cellular, Multifocal, Lymphocyte 1 (17%) 1 (33%)
Infiltration Cellular, Multifocal, Mixed Cell 1 (33%)
Inflammation, Chronic, Multifocal 1 (17%)
Inflammation, Focal, Granulomatous 1 (17%)
Fat, Necrosis 2 (33%) 1 (33%)
Pancreas (69) (5) (65) (67)
Atrophy, Diffuse 2 (3%)
Atrophy, Focal 1 (1%)
Atrophy, Multifocal 1 (1%) 1 (2%) 1 (1%)
Infiltration Cellular, Focal, Lymphocyte 3 (4%) 3 (5%) 1 (1%)
Infiltration Cellular, Multifocal, Lymphocyte 18 (26%) 17 (26%) 17 (25%)
Inflammation, Multifocal 3 (4%) 1 (2%) 1 (1%)
Vacuolization Cytoplasmic, Multifocal 1 (2%)
Acinus, Hyperplasia, Focal 1 (1%)
Duct, Dilatation 1 (1%) 2 (3%) 1 (1%)
Salivary Glands (68) (5) (64) (67)
Infiltration Cellular, Focal, Lymphocyte 3 (4%) 1 (20%) 3 (5%) 10 (15%)
Infiltration Cellular, Multifocal, Lymphocyte 40 (59%) 34 (53%) 30 (45%)
Stomach, Forestomach (67) (5) (67) (67)
Hyperkeratosis, Focal 1 (1%)
Hyperplasia, Focal 1 (1%) 1 (1%)
Stomach, Glandular (67) (5) (65) (67)
Hemorrhage, Focal 1 (1%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (1%)
Mucosa, Cyst 1 (1%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Adventitia, Inflammation, Multifocal 1 (100%)
Media, Hypertrophy, Multifocal 1 (100%)
Heart (69) (4) (68) (67)
Infiltration Cellular, Focal, Lymphocyte 1 (1%)
Mineralization, Multifocal 1 (25%)
Myocardium, Inflammation, Chronic, Focal 1 (1%)
Myocardium, Inflammation, Focal, Suppurative 1 (1%)
Valve, Pigmentation, Focal 3 (4%) 6 (9%) 6 (9%)
Valve, Pigmentation, Multifocal 7 (10%) 7 (10%) 7 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05110-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:12:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 30 PPM 30 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (66) (4) (67) (67)
Capsule, Hyperplasia, Multifocal 66 (100%) 2 (50%) 67 (100%) 66 (99%)
Capsule, Inflammation, Chronic, Multifocal 1 (2%)
Adrenal Gland, Cortex (66) (4) (67) (67)
Accessory Adrenal Cortical Nodule 1 (2%)
Congestion, Multifocal 1 (2%) 3 (4%)
Cyst 1 (2%)
Degeneration, Focal 1 (2%) 1 (1%)
Focal Cellular Change 2 (3%) 1 (1%)
Hypertrophy, Focal 1 (1%)
Pigmentation, Focal 2 (3%)
Adrenal Gland, Medulla (64) (4) (66) (66)
Congestion, Multifocal 1 (2%)
Degeneration 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Islets, Pancreatic (69) (4) (66) (67)
Hyperplasia, Focal 1 (1%)
Parathyroid Gland (68) (66) (64)
Cyst, Focal 1 (1%) 1 (2%)
Degeneration, Focal 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (2%)
Bilateral, Hyperplasia 1 (2%)
Pituitary Gland (61) (4) (50) (54)
Cyst, Multifocal 1 (2%)
Pars Distalis, Angiectasis 1 (2%) 2 (4%)
Pars Distalis, Hyperplasia 4 (7%) 1 (25%) 1 (2%)
Thyroid Gland (69) (4) (67) (66)
Infiltration Cellular, Focal, Lymphocyte 1 (1%) 2 (3%)
Inflammation, Acute, Focal 1 (1%) 2 (3%) 2 (3%)
Follicle, Dilatation, Focal 2 (3%) 2 (3%) 5 (8%)
Follicular Cell, Hyperplasia, Focal 3 (4%) 2 (3%) 4 (6%)
Follicular Cell, Hyperplasia, Multifocal 1 (1%) 1 (1%) 1 (2%)
Follicular Cell, Hypertrophy, Multifocal 1 (1%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05110-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:12:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 30 PPM 30 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (69) (14) (66) (65)
Cyst 11 (16%) 9 (64%) 16 (24%) 11 (17%)
Cyst, Multifocal 1 (1%) 1 (7%) 1 (2%) 2 (3%)
Giant Cell, Multiple 1 (2%)
Hematocyst, Focal 2 (14%) 2 (3%) 2 (3%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Multifocal, Suppurative 1 (2%)
Metaplasia, Focal, Osseous 1 (2%)
Mineralization, Multifocal 1 (2%)
Pigmentation 1 (1%)
Follicle, Hemorrhage, Focal 3 (4%) 1 (2%)
Interstitium, Hyperplasia 1 (1%)
Oviduct (2) (1) (4) (4)
Mucosa, Hyperplasia, Cystic 1 (100%)
Mucosa, Vacuolization Cytoplasmic, Multifocal 1 (50%)
Uterus (69) (41) (67) (66)
Angiectasis, Multifocal 1 (1%) 1 (2%) 1 (1%)
Dilatation 2 (5%) 7 (10%) 6 (9%)
Inflammation, Suppurative 1 (1%) 1 (2%)
Endometrium, Hyperplasia, Cystic 61 (88%) 36 (88%) 49 (73%) 56 (85%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (1) (5)
Leukocytosis 1 (100%) 3 (60%)
Bone Marrow (69) (4) (68) (67)
Angiectasis 1 (1%) 1 (1%)
Atrophy 4 (6%)
Congestion 1 (1%)
Fibrous Osteodystrophy, Focal 1 (1%)
Fibrous Osteodystrophy, Multifocal 1 (1%)
Hyperplasia 2 (3%) 1 (1%) 1 (1%)
Hyperplasia, Lymphoid 4 (6%)
Hyperplasia, Neutrophil 1 (1%)
Myelofibrosis 2 (3%) 3 (4%)
Pigmentation, Focal 1 (1%)
Pigmentation, Multifocal 1 (1%)
Lymph Node (69) (9) (67) (67)
Hyperplasia 1 (1%)
Lymph Node, Bronchial (46) (1) (46) (40)
Congestion 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (5%)
Pigmentation 1 (2%)
Lymph Node, Mandibular (66) (6) (62) (65)
Edema 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05110-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:12:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 30 PPM 30 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Erythrophagocytosis 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 2 (3%) 1 (17%) 4 (6%)
Infiltration Cellular, Histiocyte 1 (2%)
Pigmentation 15 (23%) 12 (19%) 13 (20%)
Lymph Node, Mediastinal (60) (6) (52) (57)
Angiectasis 1 (2%)
Erythrophagocytosis 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 2 (4%)
Infiltration Cellular, Histiocyte 1 (17%)
Pigmentation 8 (13%) 3 (6%) 1 (2%)
Lymph Node, Mesenteric (67) (4) (60) (62)
Erythrophagocytosis 2 (3%) 1 (2%) 1 (2%)
Giant Cell, Multifocal 17 (25%) 16 (27%) 8 (13%)
Hemorrhage 4 (6%) 2 (3%) 2 (3%)
Hyperplasia, Lymphoid 1 (1%) 1 (2%) 1 (2%)
Hyperplasia, Multifocal, Plasma Cell 1 (1%)
Infiltration Cellular, Polymorphonuclear 1 (1%)
Spleen (67) (13) (67) (67)
Angiectasis, Multifocal 1 (1%)
Congestion 1 (1%)
Hematopoietic Cell Proliferation 4 (6%) 3 (23%) 7 (10%) 10 (15%)
Hyperplasia, Lymphoid 9 (13%) 3 (23%) 6 (9%) 12 (18%)
Hyperplasia, Neutrophil 1 (1%)
Hyperplasia, Plasma Cell 1 (1%) 1 (1%)
Infiltration Cellular, Histiocyte 1 (8%)
Capsule, Inflammation, Chronic, Multifocal 1 (1%)
Thymus (64) (3) (60) (59)
Angiectasis 1 (2%)
Cyst, Multiple 1 (2%)
Depletion Lymphoid 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (69) (5) (66) (66)
Hyperplasia, Focal 2 (3%)
Infiltration Cellular, Focal, Lymphocyte 1 (2%) 1 (2%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (1%) 1 (2%) 2 (3%)
Duct, Galactocele, Multifocal 1 (2%)
Skin (69) (6) (67) (67)
Acanthosis, Multifocal 1 (1%)
Inflammation, Focal 1 (1%)
Subcutaneous Tissue, Infiltration Cellular,
Multifocal, Lymphocyte 1 (1%)
Subcutaneous Tissue, Infiltration Cellular,
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05110-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:12:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 30 PPM 30 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Multifocal, Polymorphonuclear 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (69) (4) (68) (67)
Fibrous Osteodystrophy, Focal 3 (4%) 4 (6%) 6 (9%)
Fibrous Osteodystrophy, Multifocal 7 (10%) 12 (18%) 11 (16%)
Hyperplasia, Multifocal 1 (1%)
Metaplasia, Cartilagenous, Focal 1 (1%)
Skeletal Muscle (3) (3)
Head, Hemorrhage, Multifocal 1 (33%)
Hindlimb, Infiltration Cellular, Focal,
Lymphocyte 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (69) (4) (68) (67)
Fibrosis, Multifocal 1 (1%)
Hemorrhage, Multifocal 1 (1%) 2 (3%)
Metaplasia, Focal, Osseous 1 (1%)
Mineralization, Focal 3 (4%) 1 (25%) 11 (16%) 3 (4%)
Mineralization, Multifocal 34 (49%) 8 (12%) 21 (31%)
Cerebrum, Necrosis, Focal 1 (1%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (69) (65) (68) (67)
Congestion 2 (3%) 1 (2%) 1 (1%)
Hemorrhage 1 (1%) 1 (2%) 1 (1%)
Infiltration Cellular, Lymphocyte 11 (16%) 21 (32%) 20 (29%) 26 (39%)
Infiltration Cellular, Histiocyte 1 (1%) 5 (8%) 2 (3%) 2 (3%)
Inflammation 3 (4%) 13 (20%) 34 (50%) 18 (27%)
Inflammation, Granulomatous 38 (58%) 14 (21%) 28 (42%)
Metaplasia, Focal, Osseous 1 (1%)
Alveolar Epithelium, Hyperplasia 3 (4%) 6 (9%) 5 (7%) 7 (10%)
Glands, Inflammation 1 (1%) 3 (5%) 7 (10%) 8 (12%)
Nose (69) (65) (68) (67)
Hemorrhage 1 (1%) 2 (3%) 1 (1%)
Infiltration Cellular, Multifocal, Lymphocyte 1 (1%)
Inflammation 1 (1%) 65 (100%) 68 (100%) 67 (100%)
Olfactory Epithelium, Metaplasia 65 (100%) 68 (100%) 67 (100%)
Respiratory Epithelium, Hyperplasia 65 (100%) 68 (100%) 67 (100%)
Trachea (69) (4) (68) (66)
Glands, Dilatation, Multifocal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05110-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:12:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 30 PPM 30 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Glands, Inflammation, Multifocal, Suppurative 1 (1%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (6) (2) (4)
Degeneration 3 (50%) 1 (50%)
Inflammation 1 (25%)
Mineralization 1 (50%)
Pigmentation 1 (50%) 1 (25%)
Bilateral, Lens, Cataract 1 (50%)
Cornea, Degeneration 1 (50%)
Lens, Cataract 2 (33%) 1 (50%) 2 (50%)
Optic Nerve, Degeneration 1 (50%)
Retina, Atrophy 1 (50%) 1 (25%)
Harderian Gland (1) (2) (1) (1)
Infiltration Cellular, Multifocal, Lymphocyte 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (69) (7) (67) (67)
Congestion, Multifocal 1 (1%)
Fibrosis, Focal 1 (1%)
Hemorrhage, Multifocal 1 (1%)
Infarct, Focal 1 (1%) 1 (1%)
Infiltration Cellular, Focal, Lymphocyte 2 (3%) 7 (10%) 1 (1%)
Infiltration Cellular, Multifocal, Lymphocyte 45 (65%) 1 (14%) 40 (60%) 42 (63%)
Inflammation, Acute, Focal 1 (14%)
Metaplasia, Focal, Osseous 1 (1%)
Nephropathy 3 (4%) 1 (14%) 4 (6%) 4 (6%)
Capsule, Inflammation, Chronic, Multifocal 1 (1%)
Glomerulus, Amyloid Deposition, Multifocal 1 (1%)
Renal Tubule, Hyperplasia, Focal 1 (1%)
Renal Tubule, Mineralization, Multifocal 1 (14%)
Urinary Bladder (67) (1) (62) (63)
Dilatation 1 (2%) 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 4 (6%) 6 (10%) 5 (8%)
Infiltration Cellular, Multifocal, Lymphocyte 47 (70%) 42 (68%) 37 (59%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05110-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:12:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 30 PPM 30 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 75 75 75 75
Scheduled Sacrifice 5 5 6 7
Early Deaths
Moribund 13 7 3 5
Dead 31 10 2 5
Accident 2
Survivors
Dead 1 1
Terminal Sacrifice 26 50 59 58
Accident 1
Missing 1 2
Animals Examined Microscopically 70 69 67 68
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (57) (7) (61) (65)
Dilatation 1 (14%)
Hemorrhage, Focal 1 (2%)
Epithelium, Hyperplasia, Focal, Papillary 1 (2%)
Intestine Large, Cecum (56) (5) (65) (65)
Hyperplasia, Focal, Lymphoid 1 (2%) 1 (2%)
Inflammation, Diffuse 1 (2%)
Intestine Large, Colon (56) (7) (65) (68)
Parasite Metazoan 4 (6%) 3 (4%)
Intestine Large, Rectum (58) (5) (64) (66)
Diverticulum 1 (2%)
Hemorrhage, Focal 1 (2%)
Inflammation, Diffuse 1 (2%)
Parasite Metazoan 1 (2%)
Prolapse 1 (2%)
Intestine Small (57) (8) (65) (66)
Serosa, Fibrosis 1 (13%)
Intestine Small, Duodenum (49) (5) (64) (66)
Submucosa, Dilatation, Focal 1 (2%)
Intestine Small, Ileum (51) (6) (64) (66)
Inflammation, Multifocal 1 (2%)
Intestine Small, Jejunum (51) (5) (64) (66)
Hyperplasia, Focal, Lymphoid 2 (3%)
Liver (70) (33) (67) (68)
Basophilic Focus 2 (3%) 5 (7%)
Basophilic Focus, Multifocal 1 (1%)
Clear Cell Focus 1 (1%) 2 (3%)
Clear Cell Focus, Multifocal 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05110-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:12:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 30 PPM 30 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Cyst, Focal 1 (1%)
Cytoplasmic Alteration, Focal 1 (1%)
Degeneration, Focal 1 (3%) 1 (1%)
Eosinophilic Focus 1 (1%)
Fatty Change, Focal 2 (3%)
Fibrosis, Focal 1 (1%)
Hematopoietic Cell Proliferation, Focal 1 (1%) 2 (3%) 2 (3%)
Hematopoietic Cell Proliferation, Multifocal 1 (1%) 1 (1%) 1 (1%)
Hematopoietic Cell Proliferation Granulocytic 1 (1%)
Hemorrhage, Focal 1 (1%)
Infarct, Focal 1 (1%)
Infiltration Cellular, Focal, Lymphocyte 1 (1%) 2 (3%)
Infiltration Cellular, Multifocal, Lymphocyte 3 (4%) 1 (1%)
Mineralization, Focal 1 (1%)
Mixed Cell Focus 2 (3%) 1 (1%)
Necrosis, Focal 2 (6%)
Necrosis, Multifocal 4 (6%) 2 (6%) 1 (1%)
Thrombosis, Multifocal 1 (1%)
Hepatocyte, Cytomegaly, Focal 1 (1%)
Serosa, Fibrosis 1 (3%)
Sinusoid, Ectasia, Focal 1 (1%) 1 (1%)
Mesentery (1) (1)
Fat, Necrosis, Focal 1 (100%)
Pancreas (67) (10) (66) (68)
Atrophy 3 (4%) 1 (2%) 4 (6%)
Infiltration Cellular, Focal, Lymphocyte 3 (4%) 1 (2%) 1 (1%)
Infiltration Cellular, Multifocal, Lymphocyte 3 (4%) 3 (5%) 3 (4%)
Infiltration Cellular, Polymorphonuclear 1 (1%)
Inflammation, Chronic Active, Diffuse 1 (10%)
Inflammation, Focal 1 (2%) 1 (1%)
Salivary Glands (69) (11) (67) (68)
Atrophy, Multifocal 1 (1%)
Infiltration Cellular, Focal, Lymphocyte 1 (1%) 8 (12%) 4 (6%)
Infiltration Cellular, Multifocal, Lymphocyte 13 (19%) 1 (9%) 14 (21%) 16 (24%)
Infiltration Cellular, Polymorphonuclear 1 (1%)
Stomach, Forestomach (63) (10) (65) (68)
Hyperplasia, Focal 1 (2%) 1 (1%)
Inflammation, Focal 1 (2%)
Stomach, Glandular (62) (10) (65) (68)
Cyst, Focal 1 (1%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Inflammation, Acute, Focal 1 (2%) 1 (2%)
Mineralization, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05110-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:12:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 30 PPM 30 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (70) (10) (67) (68)
Infiltration Cellular, Polymorphonuclear 1 (1%)
Myocardium, Inflammation, Multifocal 1 (1%) 1 (1%)
Valve, Pigmentation, Focal 5 (7%) 7 (10%) 5 (7%)
Valve, Pigmentation, Multifocal 4 (6%) 3 (4%) 3 (4%)
Ventricle, Thrombosis, Focal 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (66) (11) (65) (68)
Capsule, Hyperplasia, Focal 3 (5%) 2 (3%)
Capsule, Hyperplasia, Multifocal 45 (68%) 2 (18%) 49 (75%) 49 (72%)
Adrenal Gland, Cortex (66) (9) (65) (68)
Atrophy, Focal 1 (2%)
Atypia Cellular, Focal 1 (1%)
Clear Cell Focus 1 (2%)
Cyst 1 (2%)
Focal Cellular Change 1 (2%) 3 (5%)
Giant Cell, Multifocal 1 (1%)
Hyperplasia, Focal 1 (1%)
Hypertrophy, Focal 2 (3%) 4 (6%) 1 (1%)
Adrenal Gland, Medulla (66) (11) (64) (66)
Hyperplasia 1 (2%) 1 (9%)
Islets, Pancreatic (67) (9) (66) (68)
Infiltration Cellular, Focal,
Polymorphonuclear 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (1%)
Parathyroid Gland (64) (6) (62) (66)
Cyst, Focal 1 (2%) 4 (6%) 2 (3%)
Ectopic Tissue 1 (2%)
Pituitary Gland (52) (5) (58) (55)
Cyst 1 (2%)
Pars Distalis, Congestion 1 (2%)
Thyroid Gland (67) (8) (66) (68)
Cyst 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 1 (1%)
C-Cell, Hyperplasia 1 (1%)
Follicle, Dilatation, Focal 3 (4%)
Follicular Cell, Hyperplasia, Focal 1 (1%) 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05110-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:12:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 30 PPM 30 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ductus Deferens (1)
Serosa, Inflammation, Chronic 1 (100%)
Epididymis (69) (11) (67) (68)
Granuloma Sperm 2 (3%) 1 (1%)
Infiltration Cellular, Focal, Lymphocyte 1 (1%)
Infiltration Cellular, Polymorphonuclear 1 (1%)
Inflammation, Focal 1 (1%)
Spermatocele, Focal 1 (1%) 1 (1%)
Duct, Dilatation, Focal 2 (3%)
Serosa, Inflammation, Chronic 1 (9%)
Penis (2) (2) (1)
Inflammation, Multifocal 1 (50%)
Preputial Gland (4) (1) (3)
Hyperplasia 1 (33%)
Inflammation 1 (25%) 1 (33%)
Duct, Dilatation 3 (75%) 1 (100%) 1 (33%)
Prostate (65) (11) (67) (66)
Infiltration Cellular, Lymphocyte 1 (2%) 1 (9%) 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Inflammation, Acute 8 (12%) 2 (18%) 1 (2%)
Serosa, Inflammation, Chronic 1 (9%)
Seminal Vesicle (66) (16) (67) (68)
Dilatation 3 (5%) 2 (13%) 1 (1%)
Inflammation, Focal 2 (3%) 1 (1%)
Serosa, Inflammation, Chronic 2 (13%)
Testes (69) (12) (67) (68)
Angiectasis, Focal 1 (1%)
Atrophy 1 (8%) 1 (1%) 2 (3%)
Mineralization, Focal 4 (6%) 2 (3%) 4 (6%)
Thrombosis, Focal 1 (1%)
Bilateral, Atrophy 1 (1%) 1 (1%)
Interstitial Cell, Hyperplasia, Multifocal 1 (1%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (3) (1)
Leukocytosis 3 (100%) 1 (100%)
Bone Marrow (70) (10) (67) (68)
Angiectasis, Focal 1 (1%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05110-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:12:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 30 PPM 30 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Congestion 1 (1%)
Hemorrhage, Focal 1 (1%) 1 (1%)
Hyperplasia 9 (13%) 1 (1%) 5 (7%)
Myelofibrosis, Focal 1 (1%)
Thrombosis 1 (1%)
Myeloid Cell, Hyperplasia 1 (1%)
Lymph Node, Bronchial (38) (5) (57) (43)
Giant Cell, Multifocal 2 (4%) 1 (2%)
Hyperplasia, Lymphoid 1 (3%) 1 (20%) 2 (4%)
Infiltration Cellular, Polymorphonuclear 1 (3%)
Pigmentation 3 (8%) 2 (4%) 3 (7%)
Lymphocyte, Necrosis 1 (20%)
Lymph Node, Mandibular (61) (8) (59) (66)
Angiectasis 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 2 (3%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Pigmentation 12 (20%) 1 (13%) 5 (8%) 11 (17%)
Lymphocyte, Necrosis, Multifocal 1 (2%)
Lymph Node, Mediastinal (37) (4) (43) (47)
Hyperplasia, Lymphoid 1 (25%) 1 (2%) 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (3%)
Inflammation, Acute 1 (25%)
Pigmentation 2 (5%) 1 (2%) 3 (6%)
Lymph Node, Mesenteric (57) (4) (66) (63)
Angiectasis 1 (2%)
Erythrophagocytosis 7 (12%) 13 (20%) 13 (21%)
Giant Cell, Multifocal 11 (19%) 24 (36%) 16 (25%)
Hematopoietic Cell Proliferation Granulocytic 3 (5%)
Hemorrhage 12 (21%) 16 (24%) 13 (21%)
Hyperplasia, Lymphoid 1 (2%) 4 (6%) 4 (6%)
Hyperplasia, Plasma Cell 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Inflammation, Acute 3 (5%)
Lymphocyte, Necrosis, Multifocal 1 (2%) 1 (2%)
Spleen (69) (18) (67) (68)
Congestion 1 (1%) 1 (1%)
Depletion Lymphoid 1 (6%)
Hematopoietic Cell Proliferation 20 (29%) 5 (28%) 13 (19%)
Hematopoietic Cell Proliferation Granulocytic 1 (1%)
Hyperplasia, Lymphoid 1 (1%) 1 (6%) 2 (3%) 5 (7%)
Capsule, Fibrosis 1 (6%)
Lymphocyte, Necrosis 2 (3%) 1 (1%)
Thymus (47) (1) (63) (63)
Cyst 2 (4%) 4 (6%) 2 (3%)
Cyst, Multifocal 2 (3%) 2 (3%)
Depletion Lymphoid, Diffuse 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05110-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:12:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 30 PPM 30 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Ectopic Parathyroid Gland, Focal 1 (2%)
Hyperplasia, Lymphoid, Multifocal 1 (2%)
Epithelial Cell, Cytoplasmic Alteration,
Focal 1 (2%)
Thymocyte, Necrosis 8 (17%) 1 (100%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (69) (21) (67) (68)
Acanthosis, Focal 2 (3%) 1 (1%)
Cyst Epithelial Inclusion 1 (1%)
Infiltration Cellular, Polymorphonuclear 1 (1%)
Inflammation, Focal 5 (7%) 2 (10%) 1 (1%) 2 (3%)
Ulcer 4 (6%) 2 (10%)
Lymphatic, Dilatation 2 (3%)
Prepuce, Inflammation, Chronic Active 1 (1%)
Prepuce, Ulcer 3 (4%)
Subcutaneous Tissue, Angiectasis 1 (1%)
Subcutaneous Tissue, Edema, Diffuse 1 (1%)
Subcutaneous Tissue, Fibrosis, Multifocal 1 (1%) 1 (1%)
Subcutaneous Tissue, Hemorrhage 1 (1%)
Sweat Gland, Ectasia, Multifocal 1 (1%)
Tail, Inflammation, Multifocal, Necrotizing 1 (1%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (70) (11) (67) (68)
Vertebra, Developmental Malformation 1 (1%)
Vertebra, Fracture Healed 1 (9%)
Skeletal Muscle (4)
Inflammation, Chronic 3 (75%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (70) (10) (67) (68)
Mineralization, Focal 1 (1%) 7 (10%) 4 (6%)
Mineralization, Multifocal 18 (26%) 1 (10%) 25 (37%) 25 (37%)
Olfactory Lobe, Hemorrhage, Focal 1 (1%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05110-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:12:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 30 PPM 30 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (69) (9) (64) (67)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
Inflammation, Focal 1 (1%) 2 (3%)
Epithelium, Hyperplasia, Focal 2 (3%)
Lung (70) (69) (67) (68)
Congestion 9 (13%) 1 (1%)
Hemorrhage 4 (6%) 3 (4%) 5 (7%)
Infiltration Cellular, Lymphocyte 3 (4%) 4 (6%) 4 (6%)
Infiltration Cellular, Polymorphonuclear 1 (1%)
Infiltration Cellular, Histiocyte 1 (1%) 12 (17%) 11 (16%) 5 (7%)
Inflammation 21 (30%) 28 (42%) 28 (41%)
Inflammation, Granulomatous 19 (28%) 3 (4%) 12 (18%)
Alveolar Epithelium, Hyperplasia 2 (3%) 7 (10%) 8 (12%) 4 (6%)
Glands, Dilatation 2 (3%)
Glands, Inflammation 7 (10%) 14 (20%) 14 (21%) 8 (12%)
Peribronchiolar, Cyst, Multifocal 1 (1%)
Nose (70) (69) (67) (68)
Congestion, Multifocal 3 (4%)
Hemorrhage 1 (1%)
Inflammation 67 (97%) 66 (99%) 67 (99%)
Olfactory Epithelium, Metaplasia 66 (96%) 67 (100%) 67 (99%)
Respiratory Epithelium, Hyperplasia 66 (96%) 67 (100%) 67 (99%)
Trachea (70) (9) (67) (67)
Glands, Dilatation 2 (3%) 1 (1%)
Glands, Infiltration Cellular, Focal,
Lymphocyte 1 (1%)
Glands, Inflammation, Focal, Suppurative 3 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2) (1) (1)
Pinna, Inflammation, Focal 1 (50%)
Eye (3) (4) (4) (3)
Degeneration 1 (25%)
Dysplasia, Multifocal 1 (25%)
Cornea, Inflammation, Focal 1 (33%)
Iris, Hyperplasia, Multifocal, Melanocyte 1 (33%)
Lens, Cataract 1 (33%) 1 (33%)
Harderian Gland (1) (1) (1) (1)
Cyst, Multiple 1 (100%)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05110-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NAPHTHALENE Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 02:12:04
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 30 PPM 30 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (70) (16) (67) (68)
Congestion, Multifocal 1 (1%)
Degeneration 1 (6%)
Hydronephrosis 1 (1%) 1 (6%)
Hypoplasia 1 (1%)
Infarct, Focal 1 (1%) 1 (1%) 2 (3%)
Infiltration Cellular, Focal, Lymphocyte 3 (4%) 3 (4%)
Infiltration Cellular, Multifocal, Lymphocyte 17 (24%) 2 (13%) 30 (45%) 18 (26%)
Infiltration Cellular, Polymorphonuclear 1 (1%)
Inflammation, Acute, Multifocal 2 (3%) 1 (6%) 1 (1%)
Nephropathy 6 (9%) 2 (13%) 8 (12%) 6 (9%)
Pelvis, Inflammation, Acute 3 (4%)
Renal Tubule, Dilatation, Focal 1 (1%) 1 (6%) 3 (4%)
Renal Tubule, Giant Cell, Focal 1 (1%)
Renal Tubule, Hyperplasia, Focal 1 (1%) 3 (4%)
Renal Tubule, Mineralization, Focal 4 (6%) 1 (6%) 1 (1%) 3 (4%)
Urethra (1)
Distal, Dilatation 1 (100%)
Epithelium, Necrosis, Multifocal 1 (100%)
Urinary Bladder (60) (16) (66) (68)
Dilatation 7 (12%) 6 (38%) 3 (5%) 2 (3%)
Hemorrhage 2 (3%)
Infiltration Cellular, Focal, Lymphocyte 2 (3%)
Infiltration Cellular, Multifocal, Lymphocyte 6 (9%) 7 (10%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Inflammation, Acute 3 (5%)
Inflammation, Chronic Active 3 (5%) 2 (13%) 1 (1%)
Serosa, Inflammation, Chronic 1 (6%)
Transitional Epithelium, Hyperplasia,
Multifocal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
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