TDMS Study 05110-01 Pathology Tables
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
Facility: Northrop Services, Inc.
Chemical CAS #: 91-20-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 9|
| 6| 6| 6| 6| 6| 5| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + A + + + + + + + + + A + + + + + + A|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + A|
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + A|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Mesentery | + + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + A + + + + + + M|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + M|
Lymphoma Malignant Lymphocytic | X |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + M|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Capsule, Adenoma | |
Capsule, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 9|
| 6| 6| 6| 6| 6| 5| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Lymphocytic | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + M + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | M + + M + + + + + + + + + + + + + + + + + + + + M|
Lymphoma Malignant Lymphocytic | X |
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenocarcinoma, Papillary | |
Cystadenoma, Papillary | |
Granulosa Cell Tumor Benign | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
Endothelium, Sarcoma Stromal, | |
Metastatic | X |
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Sarcoma Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Iliac, Lymphoma Malignant Lymphocytic| X |
Iliac, Sarcoma Stromal, Metastatic, | |
Uterus | X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 9|
| 6| 6| 6| 6| 6| 5| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Lymphoma Malignant Lymphocytic| X |
Renal, Sarcoma Stromal, Metastatic, | |
Uterus | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + M M M M M + M + + M + M|
Lymphoma Malignant Lymphocytic | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + M + + + + + M + + + + + + + M M|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + M|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + M|
Lymphoma Malignant Lymphocytic | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Lymphoma | |
Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + M|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 9|
| 6| 6| 6| 6| 6| 5| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X |
Capsule, Lymphoma Malignant | |
Lymphocytic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X X X X X |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 0| 6| 0| 2| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + A + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Mesentery | + + + |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + M + + + + + + + + + + + + + + + +|
Capsule, Adenoma | X |
Capsule, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 0| 6| 0| 2| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Lymphocytic | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + M + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + M + + + M + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Pars Distalis, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenocarcinoma, Papillary | X |
Cystadenoma, Papillary | X |
Granulosa Cell Tumor Benign | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Endothelium, Sarcoma Stromal, | |
Metastatic | |
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | X |
__________________________________________________________________________|
Oviduct | + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Sarcoma Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Iliac, Lymphoma Malignant Lymphocytic| |
Iliac, Sarcoma Stromal, Metastatic, | |
Uterus | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 0| 6| 0| 2| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Lymphoma Malignant Lymphocytic| |
Renal, Sarcoma Stromal, Metastatic, | |
Uterus | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + M + + M M + M M + + M M + + + M + M M|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + + + + + + + M + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + A + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Spleen | + + + M + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Thymus | + M + M + + + + + + + + + + + M + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Lymphoma | |
Malignant Histiocytic | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 0| 6| 0| 2| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Capsule, Lymphoma Malignant | |
Lymphocytic | X |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| |
| 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 8| 8| 1| 8| 8| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + + + + + M + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + +| 65 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +| 66 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +| 66 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + M + + + + + + + + + + + + + + + +| 66 |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + +| 65 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + +| 68 |
Hepatocellular Adenoma | X | 2 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 6 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + +| 69 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + M + + + + + + + + + + + + + + + +| 68 |
Lymphoma Malignant Lymphocytic | | 4 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Lymphocytic | | 1 |
Squamous Cell Papilloma | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + +| 69 |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| |
| 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 8| 8| 1| 8| 8| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + M + + + + + + + + + + + + + + + +| 66 |
Capsule, Adenoma | | 1 |
Capsule, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + M + + + + + + + + + + + + + + + +| 66 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + + M + + M + + + + + + + +| 64 |
Lymphoma Malignant Lymphocytic | | 1 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +| 69 |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + + + + + + + + M + +| 61 |
Lymphoma Malignant Lymphocytic | | 1 |
Pars Distalis, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +| 69 |
Lymphoma Malignant Lymphocytic | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + +| 69 |
Cystadenocarcinoma, Papillary | | 1 |
Cystadenoma, Papillary | X | 2 |
Granulosa Cell Tumor Benign | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Endothelium, Sarcoma Stromal, | | |
Metastatic | | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Oviduct | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + +| 69 |
Lymphoma Malignant Lymphocytic | | 3 |
Sarcoma Stromal | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| |
| 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 8| 8| 1| 8| 8| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +| 69 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +| 69 |
Lymphoma Malignant Lymphocytic | | 1 |
Iliac, Lymphoma Malignant Lymphocytic| | 1 |
Iliac, Sarcoma Stromal, Metastatic, | | |
Uterus | | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
Renal, Sarcoma Stromal, Metastatic, | | |
Uterus | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + M + + + M + + + + + + + + + + +| 46 |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + +| 66 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + + + + + + + M + + + + + + + +| 60 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + +| 64 |
Lymphoma Malignant Lymphocytic | | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +| 69 |
Adenocarcinoma | X X | 2 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + +| 69 |
Lymphoma Malignant Lymphocytic | | 3 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Lymphoma | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| |
| 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 8| 8| 1| 8| 8| 8| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Malignant Histiocytic | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + +| 69 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + +| 69 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + +| 68 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + +| 69 |
Alveolar/Bronchiolar Adenoma | X X | 5 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 5 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + +| 69 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + +| 69 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + +| 69 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
Capsule, Lymphoma Malignant | | |
Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + M| 67 |
Lymphoma Malignant Lymphocytic | | 4 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +| 69 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 6 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 1| 5| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 1| 4| 4| 6| 2| 8| 4| 4| 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4|
| 8| 4| 4| 9| 7| 6| 4| 4| 4| 4| 4| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
10 PPM | 9| 9| 9| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 1| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 2| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Gallbladder | |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | + |
Adenocarcinoma | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
__________________________________________________________________________|
Liver | + + + |
Hepatocellular Adenoma | X |
Lymphoma Malignant Histiocytic | |
Sarcoma Stromal, Metastatic | |
__________________________________________________________________________|
Pancreas | + |
__________________________________________________________________________|
Salivary Glands | |
__________________________________________________________________________|
Stomach | + |
__________________________________________________________________________|
Stomach, Forestomach | + |
__________________________________________________________________________|
Stomach, Glandular | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
__________________________________________________________________________|
Islets, Pancreatic | |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | + |
__________________________________________________________________________|
Thyroid Gland | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + +|
Cystadenocarcinoma, Papillary | |
Sarcoma Stromal, Metastatic | |
__________________________________________________________________________|
Oviduct | + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 1| 5| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 1| 4| 4| 6| 2| 8| 4| 4| 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4|
| 8| 4| 4| 9| 7| 6| 4| 4| 4| 4| 4| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
10 PPM | 9| 9| 9| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 1| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 2| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Sarcoma Stromal | |
Endometrium, Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | |
__________________________________________________________________________|
Lymph Node | + + |
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Iliac, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Bronchial | |
__________________________________________________________________________|
Lymph Node, Mandibular | + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mediastinal | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | |
Adenocarcinoma | |
__________________________________________________________________________|
Skin | + + |
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Fibrosarcoma, Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 1| 5| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 1| 4| 4| 6| 2| 8| 4| 4| 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4|
| 8| 4| 4| 9| 7| 6| 4| 4| 4| 4| 4| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
10 PPM | 9| 9| 9| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 1| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 2| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Pinna, Fibrosarcoma | X |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
Adenocarcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + |
__________________________________________________________________________|
Urinary Bladder | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 0| 1| 0| 7| 7| 7| 7| 5| 7| 7| 2| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 1| 1| 1| 1| 1| 4| 9| 8| 9| 4| 4| 4| 4| 4| 4| 4| 8| 4| 4| 4|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 1| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 PPM | 6| 6| 6| 6| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + |
__________________________________________________________________________|
Gallbladder | + A + |
__________________________________________________________________________|
Intestine Large | + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + M A |
__________________________________________________________________________|
Intestine Large, Colon | + M + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + |
__________________________________________________________________________|
Intestine Small | + + + A A |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A A |
Adenocarcinoma | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Small, Ileum | + M A |
__________________________________________________________________________|
Intestine Small, Jejunum | + M A |
__________________________________________________________________________|
Liver | + + + + |
Hepatocellular Adenoma | X |
Lymphoma Malignant Histiocytic | |
Sarcoma Stromal, Metastatic | |
__________________________________________________________________________|
Pancreas | + + + |
__________________________________________________________________________|
Salivary Glands | + + + + |
__________________________________________________________________________|
Stomach | + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + |
__________________________________________________________________________|
Parathyroid Gland | M M M |
__________________________________________________________________________|
Pituitary Gland | + M + |
__________________________________________________________________________|
Thyroid Gland | + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + M + + + +|
Cystadenocarcinoma, Papillary | |
Sarcoma Stromal, Metastatic | |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 0| 1| 0| 7| 7| 7| 7| 5| 7| 7| 2| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 1| 1| 1| 1| 1| 4| 9| 8| 9| 4| 4| 4| 4| 4| 4| 4| 8| 4| 4| 4|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 1| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 PPM | 6| 6| 6| 6| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Sarcoma Stromal | |
Endometrium, Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + |
__________________________________________________________________________|
Lymph Node | + + + + |
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Iliac, Lymphoma Malignant Mixed | |
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thymus | + M + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + |
Adenocarcinoma | X |
__________________________________________________________________________|
Skin | + + + |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Fibrosarcoma, Metastatic, Skin | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 0| 1| 0| 7| 7| 7| 7| 5| 7| 7| 2| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 1| 1| 1| 1| 1| 4| 9| 8| 9| 4| 4| 4| 4| 4| 4| 4| 8| 4| 4| 4|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 1| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 PPM | 6| 6| 6| 6| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Fibrosarcoma | |
__________________________________________________________________________|
Eye | + + + + |
__________________________________________________________________________|
Harderian Gland | |
Adenocarcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + |
__________________________________________________________________________|
Urinary Bladder | M M + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| |
| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
10 PPM | 6| 6| 6| 6| 6| 7| 1| 1| 1| 1| 2| 5| 5| 5| 5| 2| 2| 3| 3| 3| 5| 6| 6| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 1| 2| 3| 4| 1| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 1| 2| 1| 2| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 4 |
__________________________________________________________________________|____________|
Gallbladder | A | 2 |
__________________________________________________________________________|____________|
Intestine Large | A | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A | 3 |
__________________________________________________________________________|____________|
Intestine Small | A | 4 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A | 4 |
Adenocarcinoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + | 12 |
Hepatocellular Adenoma | | 2 |
Lymphoma Malignant Histiocytic | X X | 2 |
Sarcoma Stromal, Metastatic | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + | 5 |
__________________________________________________________________________|____________|
Stomach | + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + | 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + | 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 4 |
__________________________________________________________________________|____________|
Parathyroid Gland | M | |
__________________________________________________________________________|____________|
Pituitary Gland | + M | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| |
| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
10 PPM | 6| 6| 6| 6| 6| 7| 1| 1| 1| 1| 2| 5| 5| 5| 5| 2| 2| 3| 3| 3| 5| 6| 6| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 1| 2| 3| 4| 1| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 1| 2| 1| 2| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + M + + + + | 14 |
Cystadenocarcinoma, Papillary | X | 1 |
Sarcoma Stromal, Metastatic | X | 1 |
__________________________________________________________________________|____________|
Oviduct | | 1 |
__________________________________________________________________________|____________|
Uterus | M + + + + + + + + + + + + + + + + +| 41 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Sarcoma Stromal | X X | 2 |
Endometrium, Polyp Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 4 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 9 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Iliac, Lymphoma Malignant Mixed | X | 1 |
Renal, Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 6 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + | 6 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + | 4 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Spleen | A + + + + + + + | 13 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________|____________|
Thymus | M + | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 5 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Skin | + | 6 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 4 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| |
| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
10 PPM | 6| 6| 6| 6| 6| 7| 1| 1| 1| 1| 2| 5| 5| 5| 5| 2| 2| 3| 3| 3| 5| 6| 6| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 1| 2| 3| 4| 1| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 1| 2| 1| 2| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + | 4 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Alveolar/Bronchiolar Adenoma | | 1 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 1 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Lymphoma Malignant Histiocytic | X | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Adenoma | | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Trachea | + | 4 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Pinna, Fibrosarcoma | | 1 |
__________________________________________________________________________|____________|
Eye | + | 6 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Adenocarcinoma | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 7 |
__________________________________________________________________________|____________|
Urinary Bladder | M | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Lymphoma Malignant Histiocytic | X X | 2 |
Lymphoma Malignant Lymphocytic | X X X | 5 |
Lymphoma Malignant Mixed | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 1| 2|
| 3| 9| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 2| 8| 6| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + M + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + + + + + + + + + + A A A + A +|
__________________________________________________________________________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M + + + + + + + + + + + + + + + + + + + A M + M A|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Large, Colon | M + + + + + + + + + + + + + + + + + + + A M + M +|
__________________________________________________________________________|
Intestine Large, Rectum | A M + + + + + + + + + + + + + + + + + + M A + + +|
__________________________________________________________________________|
Intestine Small | M + + + + + + + + + + + + + + + + + + + A M + M A|
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + + + + + + + + + + + + + + + + + A M + M A|
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + + + + + + + + + + + + A M + M A|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Intestine Small, Jejunum | M + + + + + + + + + + + + + + + + + + + A M + M A|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + A + + +|
Hepatocellular Carcinoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Plasma Cell Tumor Malignant | |
__________________________________________________________________________|
Mesentery | + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + + + + + + + + + + + + A + A +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + M + + A + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | M + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach, Glandular | M + + + + + + + + + + + + + + + + + + + + A + + M|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
Osteosarcoma, Metastatic, Bone | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
Capsule, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + A + + +|
Osteosarcoma, Metastatic, Bone | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 1| 2|
| 3| 9| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 2| 8| 6| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + A + + +|
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | M + M + + M + + M + + M + + + + + + M + + + + M M|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | +|
Osteosarcoma, Metastatic, Bone | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | M + + + + + + + + + + + + + + + + + + + + M + + +|
Cystadenoma, Papillary | X X |
Granulosa Cell Tumor Benign | |
Lymphoma Malignant Lymphocytic | X |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Oviduct | + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + A + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + M + + +|
Renal, Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + + + M + + M + M + M + M M + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + M + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + M + M + + + M + + M + M +|
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + M M|
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + A + + +|
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X X |
Plasma Cell Tumor Malignant | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + M + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 1| 2|
| 3| 9| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 2| 8| 6| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | |
Hindlimb, Fibrosarcoma | |
Sternal, Osteosarcoma, Metastatic, | |
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | X |
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Lymphoma Malignant Histiocytic, | |
Metastatic, Liver | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 1| 2|
| 3| 9| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 2| 8| 6| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | X |
Lymphoma Malignant Mixed | X X |
Plasma Cell Tumor Malignant | |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
Lymphoma Malignant Mixed | X X X |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 4| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 5| 3| 1| 4| 4| 6| 4| 4| 4| 4| 6|
| 9| 9| 9| 9| 9| 9| 6| 9| 1| 9| 9| 9| 9| 4| 1| 9| 4| 2| 2| 6| 2| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + M + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Plasma Cell Tumor Malignant | |
__________________________________________________________________________|
Mesentery | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + M|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Osteosarcoma, Metastatic, Bone | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma, Metastatic, Bone | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 4| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 5| 3| 1| 4| 4| 6| 4| 4| 4| 4| 6|
| 9| 9| 9| 9| 9| 9| 6| 9| 1| 9| 9| 9| 9| 4| 1| 9| 4| 2| 2| 6| 2| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + M + M + + M + + M + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Osteosarcoma, Metastatic, Bone | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma, Papillary | X X |
Granulosa Cell Tumor Benign | X |
Lymphoma Malignant Lymphocytic | |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Oviduct | + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Renal, Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M M + + + + M + + + + M + + + + + + + + + M|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + + M M + + + + M + + + + M + + M|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + M + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Plasma Cell Tumor Malignant | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 4| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 5| 3| 1| 4| 4| 6| 4| 4| 4| 4| 6|
| 9| 9| 9| 9| 9| 9| 6| 9| 1| 9| 9| 9| 9| 4| 1| 9| 4| 2| 2| 6| 2| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | +|
Hindlimb, Fibrosarcoma | |
Sternal, Osteosarcoma, Metastatic, | |
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + M + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Lymphoma Malignant Histiocytic, | |
Metastatic, Liver | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 4| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 5| 3| 1| 4| 4| 6| 4| 4| 4| 4| 6|
| 9| 9| 9| 9| 9| 9| 6| 9| 1| 9| 9| 9| 9| 4| 1| 9| 4| 2| 2| 6| 2| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Plasma Cell Tumor Malignant | |
__________________________________________________________________________|
Urinary Bladder | M + + + + + + + + + + + M + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 0| 7| 4| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 9| 4| 2| 4| 8| 4| 4| 7| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 4| 4| 4| 4| 4| 2| 1| 2| 7| 2| 8| 2| 2| 7| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Gallbladder | + + M + A + + + + + + + + + + + + + +| 60 |
__________________________________________________________________________|____________|
Intestine Large | + + M + + + + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + M + A + + + + + + + + + + + + + +| 60 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + M + + + + + + + + + + + + + + + +| 62 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + +| 63 |
__________________________________________________________________________|____________|
Intestine Small | + + M + + + + + + + + + + + + + + + +| 61 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + M + + + + + + + + + + + + + + + +| 61 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + M + + + + + + + + + + + + + + + +| 61 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + M + + + + + + + + + + + + + + + +| 61 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + +| 67 |
Hepatocellular Carcinoma | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 3 |
Plasma Cell Tumor Malignant | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + +| 65 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + M + + + + + + + + + + + + + + + +| 64 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +| 65 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + +| 68 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 1 |
Osteosarcoma, Metastatic, Bone | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 0| 7| 4| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 9| 4| 2| 4| 8| 4| 4| 7| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 4| 4| 4| 4| 4| 2| 1| 2| 7| 2| 8| 2| 2| 7| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +| 67 |
Capsule, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +| 67 |
Osteosarcoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +| 66 |
Osteosarcoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M M + + + + + + + M + + + + M M +| 50 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
Osteosarcoma, Metastatic, Bone | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + +| 66 |
Cystadenoma, Papillary | | 4 |
Granulosa Cell Tumor Benign | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
Osteosarcoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________|____________|
Oviduct | | 4 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +| 68 |
Osteosarcoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + +| 67 |
Renal, Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M + M + + + + + + M M M M + M + M| 46 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M + + + + + M + + + + + + + + + +| 62 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 0| 7| 4| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 9| 4| 2| 4| 8| 4| 4| 7| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 4| 4| 4| 4| 4| 2| 1| 2| 7| 2| 8| 2| 2| 7| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + M + + + + + M M + + + + + + +| 52 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + M + + M + + + + + +| 60 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 4 |
Plasma Cell Tumor Malignant | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + M + M + + + + M + + M + M + + + +| 60 |
Lymphoma Malignant Lymphocytic | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + + + + + + + + + +| 66 |
Adenocarcinoma | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Skin | + + M + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Lymphocytic | | 2 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + +| 68 |
Femur, Osteosarcoma | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 3 |
Hindlimb, Fibrosarcoma | X | 1 |
Sternal, Osteosarcoma, Metastatic, | | |
Bone | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + +| 68 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + M + + + + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + +| 68 |
Adenocarcinoma, Metastatic, Mammary | | |
Gland | | 1 |
Alveolar/Bronchiolar Adenoma | X X | 9 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X X| 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 0| 7| 4| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 9| 4| 2| 4| 8| 4| 4| 7| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 4| 4| 4| 4| 4| 2| 1| 2| 7| 2| 8| 2| 2| 7| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lymphoma Malignant Histiocytic, | | |
Metastatic, Liver | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 1 |
Osteosarcoma, Metastatic, Bone | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + +| 68 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Lymphocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
Plasma Cell Tumor Malignant | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + M + + + + + + + M + + + + + + +| 62 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + +| 68 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 2 |
Lymphoma Malignant Mixed | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 4| 5| 2| 7| 4| 4| 5| 4| 2| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 3| 4| 4|
| 3| 8| 3| 8| 3| 1| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + + + + + + + + + + + + + M A + +|
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + M + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A A + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
Osteosarcoma, Metastatic, Bone | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Mesentery | + |
Lymphoma Malignant Lymphocytic | |
Fat, Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
Lymphoma Malignant Histiocytic | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 4| 5| 2| 7| 4| 4| 5| 4| 2| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 3| 4| 4|
| 3| 8| 3| 8| 3| 1| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Lymphoma Malignant | |
Histiocytic | X |
Capsule, Sarcoma, Metastatic, | |
Uncertain Primary Site | X |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M M + + + M + + + + M + + + + + M M + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Ovary | + + + M + + + + + + + + + + + + + + + + + + + +|
Granulosa-Theca Tumor Benign | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
Teratoma Benign | |
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | |
__________________________________________________________________________|
Oviduct | + + + + |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Endometrium, Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 4| 5| 2| 7| 4| 4| 5| 4| 2| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 3| 4| 4|
| 3| 8| 3| 8| 3| 1| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Osteosarcoma, Metastatic, | |
Bone | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M M M M + M + + M M + + M M M + M + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M M + + + + + + + + + + + M + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
Capsule, Sarcoma, Metastatic, | |
Uncertain Primary Site | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + M M + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Lymphoma | |
Malignant Histiocytic | X |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 4| 5| 2| 7| 4| 4| 5| 4| 2| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 3| 4| 4|
| 3| 8| 3| 8| 3| 1| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Humerus, Osteosarcoma | X |
__________________________________________________________________________|
Skeletal Muscle | + |
Back, Osteosarcoma, Metastatic, Bone | X |
Hindlimb, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X X |
Alveolar/Bronchiolar Carcinoma | X|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
Osteosarcoma, Metastatic, Bone | X |
Sarcoma, Metastatic, Skin | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
Mediastinum, Lymphoma Malignant | |
Lymphocytic | |
Mediastinum, Sarcoma, Metastatic, | |
Uncertain Primary Site | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lids, Squamous Cell Papilloma | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 4| 5| 2| 7| 4| 4| 5| 4| 2| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 3| 4| 4|
| 3| 8| 3| 8| 3| 1| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 9|
| 3| 3| 3| 3| 3| 7| 5| 3| 3| 3| 3| 0| 3| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + M|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + M|
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X X |
Osteosarcoma, Metastatic, Bone | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Mesentery | + |
Lymphoma Malignant Lymphocytic | |
Fat, Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
Lymphoma Malignant Histiocytic | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 9|
| 3| 3| 3| 3| 3| 7| 5| 3| 3| 3| 3| 0| 3| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Lymphoma Malignant | |
Histiocytic | |
Capsule, Sarcoma, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + M + + + + + + + + M|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + M|
Granulosa-Theca Tumor Benign | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
Teratoma Benign | |
Periovarian Tissue, Lymphoma | |
Malignant Lymphocytic | |
__________________________________________________________________________|
Oviduct | |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + M|
Lymphoma Malignant Histiocytic | |
Endometrium, Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 9|
| 3| 3| 3| 3| 3| 7| 5| 3| 3| 3| 3| 0| 3| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Inguinal, Osteosarcoma, Metastatic, | |
Bone | |
__________________________________________________________________________|
Lymph Node, Bronchial | M M + M + M + + + M + M M + M M M + M + + + M +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | |
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + M M + + + + + + + M + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + M + + + + + + M|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Mixed | X |
Capsule, Sarcoma, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Thymus | + + + + + M + + + + M + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + +|
Adenocarcinoma | X |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Lymphoma | |
Malignant Histiocytic | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 9|
| 3| 3| 3| 3| 3| 7| 5| 3| 3| 3| 3| 0| 3| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Humerus, Osteosarcoma | |
__________________________________________________________________________|
Skeletal Muscle | + |
Back, Osteosarcoma, Metastatic, Bone | |
Hindlimb, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + M + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | X |
Alveolar/Bronchiolar Adenoma | X X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X |
Osteosarcoma, Metastatic, Bone | |
Sarcoma, Metastatic, Skin | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
Mediastinum, Lymphoma Malignant | |
Lymphocytic | |
Mediastinum, Sarcoma, Metastatic, | |
Uncertain Primary Site | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Mixed | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lids, Squamous Cell Papilloma | X |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 9|
| 3| 3| 3| 3| 3| 7| 5| 3| 3| 3| 3| 0| 3| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Mixed | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + M|
Lymphoma Malignant Histiocytic | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
Lymphoma Malignant Mixed | X X |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 1| 2| |
| 4| 4| 4| 4| 4| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + +| 64 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + +| 63 |
Lymphoma Malignant Histiocytic | X| 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +| 63 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +| 63 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +| 63 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + +| 67 |
Hepatocellular Adenoma | X | 2 |
Lymphoma Malignant Histiocytic | X| 3 |
Lymphoma Malignant Mixed | | 2 |
Osteosarcoma, Metastatic, Bone | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Lymphoma Malignant Lymphocytic | X | 1 |
Fat, Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Histiocytic | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +| 67 |
Fibrosarcoma | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +| 67 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +| 67 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 1| 2| |
| 4| 4| 4| 4| 4| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + +| 67 |
Fibrous Histiocytoma | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +| 67 |
Capsule, Lymphoma Malignant | | |
Histiocytic | | 1 |
Capsule, Sarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Histiocytic | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + M + + + + + M + + + M| 54 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + +| 66 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + +| 65 |
Granulosa-Theca Tumor Benign | | 1 |
Lymphoma Malignant Histiocytic | X| 2 |
Lymphoma Malignant Mixed | | 1 |
Teratoma Benign | X | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Oviduct | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 1| 2| |
| 4| 4| 4| 4| 4| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + +| 66 |
Lymphoma Malignant Histiocytic | X| 2 |
Endometrium, Polyp Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + +| 5 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +| 67 |
Hemangioma | | 1 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + +| 67 |
Inguinal, Osteosarcoma, Metastatic, | | |
Bone | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + + + + + M + + M + + M| 40 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + M + + + +| 65 |
Fibrosarcoma | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + + + M + + + M + M + + + +| 57 |
Lymphoma Malignant Histiocytic | X| 2 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M| 62 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + +| 67 |
Hemangiosarcoma | | 3 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 1| 2| |
| 4| 4| 4| 4| 4| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Capsule, Sarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + + + M M| 59 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +| 66 |
Adenocarcinoma | | 2 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + +| 67 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 2 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Histiocytic | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + +| 67 |
Humerus, Osteosarcoma | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
Back, Osteosarcoma, Metastatic, Bone | | 1 |
Hindlimb, Hemangiosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Mixed | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + M + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + +| 67 |
Adenocarcinoma, Metastatic, Mammary | | |
Gland | | 1 |
Alveolar/Bronchiolar Adenoma | X X X X | 12 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 3 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Lymphoma Malignant Histiocytic | | 2 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 1| 2| |
| 4| 4| 4| 4| 4| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Lymphoma Malignant Mixed | | 1 |
Osteosarcoma, Metastatic, Bone | | 1 |
Sarcoma, Metastatic, Skin | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
Mediastinum, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
Mediastinum, Sarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Mixed | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + M + + + + + + + + + + + + +| 66 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 4 |
Lids, Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + M + + + + + + + + + M +| 63 |
Lymphoma Malignant Histiocytic | X| 2 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Histiocytic | X| 3 |
Lymphoma Malignant Lymphocytic | X X | 2 |
Lymphoma Malignant Mixed | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 6| 3| 5| 7| 7| 2| 7| 3| 7| 6| 7| 3| 7| 7| 7| 6| 3| 6| 7| 1| 7| 7| 7| 1| 7|
DAY ON TEST | 5| 9| 5| 3| 0| 8| 3| 8| 3| 9| 1| 8| 3| 3| 3| 8| 8| 2| 0| 3| 3| 3| 0| 8| 3|
| 2| 6| 8| 6| 6| 2| 6| 3| 6| 7| 4| 9| 6| 6| 6| 8| 2| 0| 0| 4| 6| 6| 6| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + A + + A + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + A + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A A + A + + M + A + + + + + + A + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + A + + A + A + + + + + + A + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + A + + + + + + + + A + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + A + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | M + M + + + M M + + + M + M + + + M + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | M + + + A + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | M + |
__________________________________________________________________________|
Prostate | + + + + A + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + M + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 6| 3| 5| 7| 7| 2| 7| 3| 7| 6| 7| 3| 7| 7| 7| 6| 3| 6| 7| 1| 7| 7| 7| 1| 7|
DAY ON TEST | 5| 9| 5| 3| 0| 8| 3| 8| 3| 9| 1| 8| 3| 3| 3| 8| 8| 2| 0| 3| 3| 3| 0| 8| 3|
| 2| 6| 8| 6| 6| 2| 6| 3| 6| 7| 4| 9| 6| 6| 6| 8| 2| 0| 0| 4| 6| 6| 6| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node | + M + + A + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
Iliac, Lymphoma Malignant Lymphocytic| |
Renal, Lymphoma Malignant Lymphocytic| |
__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M + + + + + + M + M M M + + M + + M M +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + M + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M + M M + + M + + M + + M + + M + + M + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + A M + M + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Thymus | + M M + M + + M M M M + + + + M + + M M + + M + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M + M M M M M M + M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | X X X|
Subcutaneous Tissue, Fibroma, | |
Multiple | |
Subcutaneous Tissue, Fibrosarcoma | X X X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | X |
Subcutaneous Tissue, Lymphoma | |
Malignant Histiocytic | X |
Subcutaneous Tissue, | |
Neurofibrosarcoma | X |
Subcutaneous Tissue, Sarcoma | X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 6| 3| 5| 7| 7| 2| 7| 3| 7| 6| 7| 3| 7| 7| 7| 6| 3| 6| 7| 1| 7| 7| 7| 1| 7|
DAY ON TEST | 5| 9| 5| 3| 0| 8| 3| 8| 3| 9| 1| 8| 3| 3| 3| 8| 8| 2| 0| 3| 3| 3| 0| 8| 3|
| 2| 6| 8| 6| 6| 2| 6| 3| 6| 7| 4| 9| 6| 6| 6| 8| 2| 0| 0| 4| 6| 6| 6| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
Lymphoma Malignant Lymphocytic | |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | +|
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 2| 0| 3| 7| 3| 7| 1| 1| 3| 7| 4| 7| 0| 4| 7| 7| 7| 7| 7| 7| 0| 0| 7| 0| 0|
DAY ON TEST | 3| 4| 2| 3| 6| 3| 1| 5| 2| 3| 2| 3| 8| 6| 3| 3| 3| 3| 3| 3| 8| 8| 3| 8| 8|
| 5| 8| 7| 6| 1| 6| 2| 8| 0| 6| 1| 6| 3| 5| 6| 6| 6| 6| 6| 6| 8| 3| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + M + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A + M + + + A + + + + + + + A + + A M|
__________________________________________________________________________|
Intestine Large | + A A + + + A + A + + + + + + + + + + + A A + + M|
__________________________________________________________________________|
Intestine Large, Cecum | + A A + + + A + A + + + + + + + + + + + A A + A M|
__________________________________________________________________________|
Intestine Large, Colon | + A A + + + A + A + + + + + + + + + + + A A + A M|
__________________________________________________________________________|
Intestine Large, Rectum | + M A + + + A + A + + + + + + + + + + + A A + + M|
__________________________________________________________________________|
Intestine Small | + A + + + + A + A + + + + + + + + + + + A A + A M|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + A + A + A + A + + + + + + + A A + A M|
__________________________________________________________________________|
Intestine Small, Ileum | + A A + + + A + A + + + + + + + + + + + A A + A M|
__________________________________________________________________________|
Intestine Small, Jejunum | A A A + + + A + A + A + + A + + + + + + A A + A M|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + A|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + A + + + + A + + + + + + + + + + + + + A + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + A + + + + A + + + + + + + + + + + + + A + + + A|
__________________________________________________________________________|
Stomach, Glandular | + A + + + + A + M + + + + + + + + + + + A + + + A|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + M + M + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + M + M + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + M + M + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + A|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + M + + M + + + + + + + + + M|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + |
__________________________________________________________________________|
Prostate | + + + + + + A + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + A + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 2| 0| 3| 7| 3| 7| 1| 1| 3| 7| 4| 7| 0| 4| 7| 7| 7| 7| 7| 7| 0| 0| 7| 0| 0|
DAY ON TEST | 3| 4| 2| 3| 6| 3| 1| 5| 2| 3| 2| 3| 8| 6| 3| 3| 3| 3| 3| 3| 8| 8| 3| 8| 8|
| 5| 8| 7| 6| 1| 6| 2| 8| 0| 6| 1| 6| 3| 5| 6| 6| 6| 6| 6| 6| 8| 3| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Iliac, Lymphoma Malignant Lymphocytic| X |
Renal, Lymphoma Malignant Lymphocytic| X |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M + + + M M M + + + M M M M + + M + + M + M +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M M + + + M + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + M + M M M M M M + M + M + M + + + M M + M M|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + M M + + + + + + + M + + + + M + + + M|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Thymus | + + + + + + M + M + + + M + + + + + + + M M + M +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibroma, | |
Multiple | |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | |
Subcutaneous Tissue, Lymphoma | |
Malignant Histiocytic | |
Subcutaneous Tissue, | |
Neurofibrosarcoma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 2| 0| 3| 7| 3| 7| 1| 1| 3| 7| 4| 7| 0| 4| 7| 7| 7| 7| 7| 7| 0| 0| 7| 0| 0|
DAY ON TEST | 3| 4| 2| 3| 6| 3| 1| 5| 2| 3| 2| 3| 8| 6| 3| 3| 3| 3| 3| 3| 8| 8| 3| 8| 8|
| 5| 8| 7| 6| 1| 6| 2| 8| 0| 6| 1| 6| 3| 5| 6| 6| 6| 6| 6| 6| 8| 3| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant Lymphocytic | X |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | +|
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + A A + + + A + + + + + + + + + + + + + A + + + M|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 5| 0| 7| 5| 7| 0| 6| 7| 1| 7| 7| 0| 6| 6| 7| 7| 3| 7| 2| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 9| 8| 3| 8| 0| 4| 5| 3| 9| 1| 2| 1| 8| 5| 3| 3| 2| 3| 5| 3| |
| 4| 4| 4| 4| 4| 0| 4| 6| 9| 4| 8| 5| 6| 6| 5| 5| 5| 1| 4| 6| 6| 6| 6| 5| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + M +| 66 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + A + + + + + + + + + + + + A +| 57 |
__________________________________________________________________________|____________|
Intestine Large | + A + + + A + + + + + + + + + + + + A +| 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + A + + A + + + + + + + + + A +| 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + M + A + + + + + + + + + + + + A +| 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + A + + A + + + + + + + + + A +| 58 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + A + + + + + + + + + A +| 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + A + + A + + + + + + + A + A +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + A + + A + + + + + + + A + A +| 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A A + + A + + + + + + + + + A +| 51 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + +| 70 |
Hepatocellular Carcinoma | X X | 6 |
Hepatocellular Adenoma | X X | 3 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Salivary Glands | + + + M + + + + + + + + + + + + + + + +| 69 |
__________________________________________________________________________|____________|
Stomach | + A + + + + + + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + + + A +| 63 |
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + +| 62 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + +| 70 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + M + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + M + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + +| 66 |
Pheochromocytoma Benign | X | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + M + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + M M M + + M + M + + + M + M + + +| 52 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +| 67 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 5| 0| 7| 5| 7| 0| 6| 7| 1| 7| 7| 0| 6| 6| 7| 7| 3| 7| 2| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 9| 8| 3| 8| 0| 4| 5| 3| 9| 1| 2| 1| 8| 5| 3| 3| 2| 3| 5| 3| |
| 4| 4| 4| 4| 4| 0| 4| 6| 9| 4| 8| 5| 6| 6| 5| 5| 5| 1| 4| 6| 6| 6| 6| 5| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + +| 69 |
__________________________________________________________________________|____________|
Penis | + | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 4 |
__________________________________________________________________________|____________|
Prostate | + + + M + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + +| 69 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 3 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +| 70 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Lymphocytic | | 1 |
Iliac, Lymphoma Malignant Lymphocytic| | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + M + M + + + M + M + + + + M + + M| 38 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + M + M + + + + + M| 61 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + M M M + M + + + + + + + + + + M +| 37 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + M + + + M + + + + + + +| 57 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + +| 69 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Thymus | + M + + + M + M M + + + + M + + + + M +| 47 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M + M M M M M M + M M M M M +| 5 |
__________________________________________________________________________|____________|
Skin | + + + + + A + + + + + + + + + + + + + +| 69 |
Subcutaneous Tissue, Fibroma | | 3 |
Subcutaneous Tissue, Fibroma, | | |
Multiple | X | 1 |
Subcutaneous Tissue, Fibrosarcoma | X X X X X X| 11 |
Subcutaneous Tissue, Fibrous | | |
Histiocytoma | | 1 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Histiocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 5| 0| 7| 5| 7| 0| 6| 7| 1| 7| 7| 0| 6| 6| 7| 7| 3| 7| 2| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 9| 8| 3| 8| 0| 4| 5| 3| 9| 1| 2| 1| 8| 5| 3| 3| 2| 3| 5| 3| |
| 4| 4| 4| 4| 4| 0| 4| 6| 9| 4| 8| 5| 6| 6| 5| 5| 5| 1| 4| 6| 6| 6| 6| 5| 6| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Subcutaneous Tissue, | | |
Neurofibrosarcoma | X | 2 |
Subcutaneous Tissue, Sarcoma | X X X | 6 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + +| 70 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + +| 70 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + +| 69 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + +| 70 |
Alveolar/Bronchiolar Adenoma | | 7 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 3 |
Lymphoma Malignant Lymphocytic | | 1 |
Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + +| 70 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + +| 70 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | | 3 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + +| 70 |
Adenoma | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + + + M + + A +| 60 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +| 70 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 0| 2| 6| 1| 2| 3| 3| 0| 5| 3| 6| 7| 7| 7| 7| 0| 6| 0| 0| 0| 0| 0| 7| 7| 7|
DAY ON TEST | 1| 8| 4| 1| 6| 0| 3| 3| 3| 7| 9| 4| 4| 4| 4| 3| 9| 1| 1| 1| 1| 1| 4| 4| 4|
| 4| 7| 0| 9| 5| 3| 0| 0| 6| 2| 2| 4| 4| 4| 4| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
10 PPM | 1| 2| 2| 3| 3| 3| 3| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 7| 7| 7| 7| 7| 8| 8| 8|
| 1| 1| 2| 1| 2| 3| 4| 1| 2| 1| 1| 2| 3| 4| 5| 1| 1| 1| 2| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + M M + |
__________________________________________________________________________|
Gallbladder | A + A + A + + + A + |
__________________________________________________________________________|
Intestine Large | A + + + A + + + A + |
__________________________________________________________________________|
Intestine Large, Cecum | A A + + A A + + A + |
__________________________________________________________________________|
Intestine Large, Colon | A + + + A + + + A + |
__________________________________________________________________________|
Intestine Large, Rectum | A M + + A A + + A + |
__________________________________________________________________________|
Intestine Small | A A + + A A + + A + |
__________________________________________________________________________|
Intestine Small, Duodenum | A A A + A A + + A + |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Intestine Small, Ileum | A M + + A A + + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | A M + + A A + + A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + M |
__________________________________________________________________________|
Stomach | A + + + + + + + A + |
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + A + |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + A + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + M + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + M + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + + +|
Pheochromocytoma Benign | X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + + M M + + M + |
__________________________________________________________________________|
Pituitary Gland | M + + + M M + M M + |
__________________________________________________________________________|
Thyroid Gland | + + + + M + + + A + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ductus Deferens | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + |
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | |
__________________________________________________________________________|
Prostate | + + + + + + + + M + |
__________________________________________________________________________|
Seminal Vesicle | + + + + M + + + + + |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 0| 2| 6| 1| 2| 3| 3| 0| 5| 3| 6| 7| 7| 7| 7| 0| 6| 0| 0| 0| 0| 0| 7| 7| 7|
DAY ON TEST | 1| 8| 4| 1| 6| 0| 3| 3| 3| 7| 9| 4| 4| 4| 4| 3| 9| 1| 1| 1| 1| 1| 4| 4| 4|
| 4| 7| 0| 9| 5| 3| 0| 0| 6| 2| 2| 4| 4| 4| 4| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
10 PPM | 1| 2| 2| 3| 3| 3| 3| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 7| 7| 7| 7| 7| 8| 8| 8|
| 1| 1| 2| 1| 2| 3| 4| 1| 2| 1| 1| 2| 3| 4| 5| 1| 1| 1| 2| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + + + + + + + + + + + |
Fibrosarcoma, Metastatic, Skin | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M + + M M M M M |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + M |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M M M M M + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | A M + + M M M + M M |
Lymphoma Malignant Histiocytic | |
__________________________________________________________________________|
Spleen | + + + + + + + + A + |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Thymus | M M M + M M M M M M |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X X X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + + |
Sarcoma, Metastatic, Skin | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + A + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X|
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X |
Fibrosarcoma, Metastatic | X |
Fibrosarcoma, Metastatic, Skin | |
Sarcoma, Metastatic, Skin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + M + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 0| 2| 6| 1| 2| 3| 3| 0| 5| 3| 6| 7| 7| 7| 7| 0| 6| 0| 0| 0| 0| 0| 7| 7| 7|
DAY ON TEST | 1| 8| 4| 1| 6| 0| 3| 3| 3| 7| 9| 4| 4| 4| 4| 3| 9| 1| 1| 1| 1| 1| 4| 4| 4|
| 4| 7| 0| 9| 5| 3| 0| 0| 6| 2| 2| 4| 4| 4| 4| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
10 PPM | 1| 2| 2| 3| 3| 3| 3| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 7| 7| 7| 7| 7| 8| 8| 8|
| 1| 1| 2| 1| 2| 3| 4| 1| 2| 1| 1| 2| 3| 4| 5| 1| 1| 1| 2| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + M + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 6| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 4| 3| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 4| 9| 7| 8| 4| 4| 4| 9| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 8| 8| 8| 8| 9| 9| 0| 0| 0| 3| 3| 4|
| 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 2| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Gallbladder | |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Small | + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Intestine Small, Ileum | + |
__________________________________________________________________________|
Intestine Small, Jejunum | |
__________________________________________________________________________|
Liver | + + + + + + + |
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X |
__________________________________________________________________________|
Pancreas | |
__________________________________________________________________________|
Salivary Glands | |
__________________________________________________________________________|
Stomach | |
__________________________________________________________________________|
Stomach, Forestomach | |
__________________________________________________________________________|
Stomach, Glandular | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | |
__________________________________________________________________________|
Thyroid Gland | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ductus Deferens | + |
__________________________________________________________________________|
Epididymis | + |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | |
__________________________________________________________________________|
Prostate | + |
__________________________________________________________________________|
Seminal Vesicle | + + + + |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 6| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 4| 3| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 4| 9| 7| 8| 4| 4| 4| 9| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 8| 8| 8| 8| 9| 9| 0| 0| 0| 3| 3| 4|
| 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 2| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Testes | + |
Fibrosarcoma, Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Bronchial | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mandibular | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Lymphoma Malignant Histiocytic | X |
__________________________________________________________________________|
Spleen | + + + + + |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Thymus | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | |
__________________________________________________________________________|
Skin | + + + + |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | X X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
__________________________________________________________________________|
Skeletal Muscle | + + |
Sarcoma, Metastatic, Skin | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X|
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X X |
Fibrosarcoma, Metastatic | |
Fibrosarcoma, Metastatic, Skin | X |
Sarcoma, Metastatic, Skin | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 6| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 4| 3| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 4| 9| 7| 8| 4| 4| 4| 9| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 8| 8| 8| 8| 9| 9| 0| 0| 0| 3| 3| 4|
| 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 2| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + +|
__________________________________________________________________________|
Urinary Bladder | + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 3| 4| |
| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 7| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
10 PPM | 4| 4| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 4| 7| 9| 9| 9| L |
| 2| 3| 1| 2| 3| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 1| 2| 3| 1| 1| 1| 2| 3| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 7 |
__________________________________________________________________________|____________|
Gallbladder | + | 7 |
__________________________________________________________________________|____________|
Intestine Large | | 7 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 7 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 5 |
__________________________________________________________________________|____________|
Intestine Small | | 8 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 5 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 6 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + +| 33 |
Hepatocellular Carcinoma | X | 4 |
Hepatocellular Adenoma | X X X X| 8 |
Hepatocellular Adenoma, Multiple | X | 2 |
__________________________________________________________________________|____________|
Pancreas | + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + | 11 |
__________________________________________________________________________|____________|
Stomach | + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 11 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 9 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 11 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 9 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 6 |
__________________________________________________________________________|____________|
Pituitary Gland | | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | | 8 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ductus Deferens | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 65
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 3| 4| |
| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 7| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
10 PPM | 4| 4| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 4| 7| 9| 9| 9| L |
| 2| 3| 1| 2| 3| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 1| 2| 3| 1| 1| 1| 2| 3| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 11 |
__________________________________________________________________________|____________|
Penis | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
__________________________________________________________________________|____________|
Prostate | + | 11 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 16 |
__________________________________________________________________________|____________|
Testes | | 12 |
Fibrosarcoma, Metastatic, Skin | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + | 14 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + | 5 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 4 |
Lymphoma Malignant Histiocytic | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + | 18 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Thymus | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | |
__________________________________________________________________________|____________|
Skin | + + + + | 21 |
Subcutaneous Tissue, Fibroma | X X X | 3 |
Subcutaneous Tissue, Fibrosarcoma | X | 6 |
Subcutaneous Tissue, Sarcoma | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 11 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 4 |
Sarcoma, Metastatic, Skin | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | | 9 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 69 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 66
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 3| 4| |
| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 7| 5| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
10 PPM | 4| 4| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 4| 7| 9| 9| 9| L |
| 2| 3| 1| 2| 3| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 1| 2| 3| 1| 1| 1| 2| 3| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Adenoma | X X X X X X X| 13 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X | 2 |
Alveolar/Bronchiolar Carcinoma | | 3 |
Fibrosarcoma, Metastatic | | 1 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Sarcoma, Metastatic, Skin | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 69 |
__________________________________________________________________________|____________|
Trachea | | 9 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 16 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 16 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 69 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 67
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 2| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 5|
DAY ON TEST | 3| 3| 3| 3| 8| 8| 3| 3| 3| 0| 4| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 4|
| 8| 8| 8| 8| 2| 0| 8| 8| 8| 2| 4| 8| 8| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + M + + + M +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + + + A + + + M + + M + M + M + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large | + + + + + A + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + A + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + A + + + + + + + + + + + + +|
Adenocarcinoma | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A A + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach | + + + + + A + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + A + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + A + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + M + + + + + + + + + + + + +|
Adenoma | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + + + + + + + + + + M +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + M + + + + + + + + + + + M +|
Lymphoma Malignant Lymphocytic | |
Pars Distalis, Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 2| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 5|
DAY ON TEST | 3| 3| 3| 3| 8| 8| 3| 3| 3| 0| 4| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 4|
| 8| 8| 8| 8| 2| 0| 8| 8| 8| 2| 4| 8| 8| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant | |
Lymphocytic | |
Iliac, Lymphoma Malignant Lymphocytic| |
Popliteal, Lymphoma Malignant | |
Lymphocytic | |
Renal, Lymphoma Malignant Lymphocytic| X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + M + + M + M + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + M + + M M + + + + + + + M + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + M M + + + + M + + + + + + + M M + M +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
__________________________________________________________________________|
Thymus | + + + + + M + + + + M + + + + + + + + M + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 2| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 5|
DAY ON TEST | 3| 3| 3| 3| 8| 8| 3| 3| 3| 0| 4| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 4|
| 8| 8| 8| 8| 2| 0| 8| 8| 8| 2| 4| 8| 8| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X X |
Lymphoma Malignant Lymphocytic | |
Sarcoma, Metastatic, Uncertain | |
Primary Site | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + +|
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X X |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + M + + M + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Pars Distalis, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Lymphoma Malignant | |
Lymphocytic | X |
Iliac, Lymphoma Malignant Lymphocytic| X |
Popliteal, Lymphoma Malignant | |
Lymphocytic | X |
Renal, Lymphoma Malignant Lymphocytic| X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M M M + + + + + + M M + M M + + M + + + + M +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Lymphoma | |
Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + M + + + M + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X |
Alveolar/Bronchiolar Carcinoma | X |
Lymphoma Malignant Lymphocytic | X |
Sarcoma, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 4| 4| 9| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 4| 4| 4| 4| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + +| 61 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +| 65 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M + + + + + + + + + + + + + + + +| 64 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + +| 67 |
Hepatocellular Carcinoma | | 4 |
Hepatocellular Adenoma | X X | 3 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + +| 66 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +| 65 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +| 65 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + M + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + M + + + + + + + + + + +| 65 |
Adenoma | X | 2 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + + +| 64 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 74
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 4| 4| 9| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 4| 4| 4| 4| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + +| 62 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + + + + + + + M M| 58 |
Lymphoma Malignant Lymphocytic | | 1 |
Pars Distalis, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +| 66 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + +| 67 |
Axillary, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Iliac, Lymphoma Malignant Lymphocytic| | 1 |
Popliteal, Lymphoma Malignant | | |
Lymphocytic | | 1 |
Renal, Lymphoma Malignant Lymphocytic| | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M M M + + + M + + + + + + + + M| 57 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + M + + +| 59 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + M M M M + + M M M M + +| 43 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +| 66 |
Lymphoma Malignant Lymphocytic | | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 75
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 4| 4| 9| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 4| 4| 4| 4| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + + + +| 63 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M + M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + +| 67 |
Subcutaneous Tissue, Lymphoma | | |
Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + +| 67 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + +| 67 |
Alveolar/Bronchiolar Adenoma | X X X X X | 12 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 3 |
Alveolar/Bronchiolar Carcinoma | X | 4 |
Lymphoma Malignant Lymphocytic | | 1 |
Sarcoma, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + +| 67 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 4 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 76
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 4| 4| 9| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 4| 4| 4| 4| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +| 66 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + +| 67 |
Lymphoma Malignant Lymphocytic | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 77
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 9| 4| 4| 7| 0| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + A + M + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + A A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A A + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | |
Leukemia Granulocytic | |
__________________________________________________________________________|
Mesentery | |
Leukemia Granulocytic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + M M + + M + M + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 9| 4| 4| 7| 0| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Leukemia Granulocytic | |
__________________________________________________________________________|
Preputial Gland | + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M + M M M + + + + M + + M M M + + M + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + M + + + + + + + + + + + + + + + M M M|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M M + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Subcutaneous Tissue, Fibroma | |
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | X |
Subcutaneous Tissue, | |
Neurofibrosarcoma | X |
Subcutaneous Tissue, Sarcoma | X |
Subcutaneous Tissue, Sarcoma, | |
Multiple | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 9| 4| 4| 7| 0| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | X X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Leukemia Granulocytic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 1| 9| 4| 4| 4| 4| 1| 4| 4| 4| 1| 4| 4| 4| 4| 3| 4| 4| 4| 4|
| 2| 2| 2| 2| 2| 6| 6| 3| 2| 3| 3| 1| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X X X|
Hepatocellular Adenoma, Multiple | |
Leukemia Granulocytic | X |
__________________________________________________________________________|
Mesentery | + |
Leukemia Granulocytic | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + M + + M + + + + + + + + M M + + M +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 1| 9| 4| 4| 4| 4| 1| 4| 4| 4| 1| 4| 4| 4| 4| 3| 4| 4| 4| 4|
| 2| 2| 2| 2| 2| 6| 6| 3| 2| 3| 3| 1| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
Leukemia Granulocytic | X |
__________________________________________________________________________|
Preputial Gland | |
__________________________________________________________________________|
Prostate | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M + + + + + + M + + M M + M M + + + + M M|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + M + + + + + +|
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M + M M + + + + + + + M M + + M M + + M + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + M + + + + M|
Leukemia Granulocytic | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + M + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Subcutaneous Tissue, Fibroma | X |
Subcutaneous Tissue, Fibrosarcoma | X X X X |
Subcutaneous Tissue, Fibrous | |
Histiocytoma | |
Subcutaneous Tissue, | |
Neurofibrosarcoma | |
Subcutaneous Tissue, Sarcoma | X |
Subcutaneous Tissue, Sarcoma, | |
Multiple | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 1| 9| 4| 4| 4| 4| 1| 4| 4| 4| 1| 4| 4| 4| 4| 3| 4| 4| 4| 4|
| 2| 2| 2| 2| 2| 6| 6| 3| 2| 3| 3| 1| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X |
Alveolar/Bronchiolar Carcinoma | |
Lymphoma Malignant Lymphocytic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | +|
Adenoma | X|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Leukemia Granulocytic | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 0| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 9| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| |
| 4| 4| 4| 4| 4| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +| 66 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + +| 68 |
Hemangiosarcoma | X | 1 |
Hepatocellular Carcinoma | X X | 3 |
Hepatocellular Adenoma | X X X X | 12 |
Hepatocellular Adenoma, Multiple | X | 1 |
Leukemia Granulocytic | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Leukemia Granulocytic | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + +| 68 |
Lymphoma Malignant Lymphocytic | X| 1 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +| 68 |
Leukemia Granulocytic | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +| 68 |
Leukemia Granulocytic | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + +| 68 |
Lymphoma Malignant Lymphocytic | X| 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + +| 66 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 84
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 0| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 9| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| |
| 4| 4| 4| 4| 4| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + + + + + + + M +| 55 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +| 68 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Penis | | 1 |
Leukemia Granulocytic | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | | 3 |
__________________________________________________________________________|____________|
Prostate | M + + + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + +| 68 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + +| 68 |
Leukemia Granulocytic | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + + + + + M M M + + M M + +| 43 |
Lymphoma Malignant Lymphocytic | X| 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + +| 66 |
Lymphoma Malignant Lymphocytic | X| 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M M M + + M + + M + + + + + M +| 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +| 63 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant Lymphocytic | X| 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + +| 68 |
Leukemia Granulocytic | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + + + +| 63 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + +| 68 |
Leukemia Granulocytic | | 1 |
Subcutaneous Tissue, Fibroma | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 4 |
Subcutaneous Tissue, Fibrous | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 85
NTP Experiment-Test: 05110-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NAPHTHALENE Date: 04/09/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:15:47
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 0| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 9| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| |
| 4| 4| 4| 4| 4| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Histiocytoma | | 1 |
Subcutaneous Tissue, | | |
Neurofibrosarcoma | | 1 |
Subcutaneous Tissue, Sarcoma | | 2 |
Subcutaneous Tissue, Sarcoma, | | |
Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + +| 68 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + +| 68 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + +| 68 |
Alveolar/Bronchiolar Adenoma | X X | 7 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X X | 5 |
Alveolar/Bronchiolar Carcinoma | X | 3 |
Lymphoma Malignant Lymphocytic | X| 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + +| 67 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + | 3 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + +| 68 |
Carcinoma | | 1 |
Leukemia Granulocytic | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + +| 68 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant Lymphocytic | X| 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 86
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