TDMS Study 05110-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Northrop Services NAPHTHALENE DATE: 09/14/94
EXPERIMENT: 05110 TEST: 01 TIME: 02:28:50
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1ES790009 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 52904B
PATHOLOGIST: L. BRENNECKE CAS: 91-20-3
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Northrop Services NAPHTHALENE DATE: 09/14/94
EXPERIMENT: 05110 TEST: 01 TIME: 02:28:50
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1ES790009 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 52904B
PATHOLOGIST: L. BRENNECKE CAS: 91-20-3
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Northrop Services NAPHTHALENE DATE: 09/14/94
EXPERIMENT: 05110 TEST: 01 TIME: 02:28:50
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1ES790009 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 52904B
PATHOLOGIST: L. BRENNECKE CAS: 91-20-3
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF NAPHTHALENE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Skin: Subcutaneous Tissue Fibroma
Fibrosarcoma
Neurofibrosarcoma, Fibrosarcoma, Sarcoma,
Neurofibroma, or Fibroma
Neurofibrosarcoma, Fibrosarcoma, or Sarcoma
Sarcoma
All Organs Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Stomach, Forestomach Squamous Cell Papilloma
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/14/94 EXPERIMENT: 05110 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NAPHTHALENE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 30 PPM | CONTROL 10 PPM 30 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/66 (0%) 0/9 (0%) 2/133 (2%) | 0/66 (0%) 0/4 (0%) 0/134 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 1.7% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/25 (0%) 0/0 2/117 (2%) | 0/57 (0%) 0/0 0/101 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 736 (T) | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.486 (e) P=0.609 | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.486 (e) P=0.609 | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.486 (e) P=0.609 | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.292 | (e) |
|FISHER EXACT | (e) P=0.446 | (e) (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/66 (3%) 1/11 (9%) 1/130 (1%) | 1/64 (2%) 0/4 (0%) 0/132 (0%) |
|ADJUSTED (b) | 6.0% 50.0% 0.9% | 1.8% 0.0% 0.0% |
|TERMINAL (d) | 1/25 (4%) 1/2 (50%) 1/115 (1%) | 1/55 (2%) 0/0 0/99 (0%) |
|FIRST INCIDENCE (DAYS) | 389 736 (T) 736 (T) | 736 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.036N* P=0.633 P=0.104N | P=0.259N (e) P=0.383N |
|INCIDENTAL TUMOR | P=0.091N P=0.339 P=0.285N | P=0.259N (e) P=0.383N |
|LOGISTIC REGRESSION | P=0.108N P=0.327 P=0.291N | P=0.259N (e) P=0.383N |
|COCHRAN-ARMITAGE | P=0.160N | P=0.237N |
|FISHER EXACT | P=0.374 P=0.263N | P=0.941N P=0.327N |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05110 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NAPHTHALENE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 30 PPM | CONTROL 10 PPM 30 PPM |
| | | |
|=================================================================================================================================|
| |
|Bone |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/69 (0%) 0/135 (0%) | 0/69 (0%) 0/65 (0%) 2/135 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 0.0% 1.7% |
|TERMINAL (d) | 0/26 (0%) 0/52 (0%) 0/118 (0%) | 0/59 (0%) 0/57 (0%) 0/102 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- --- 427 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.197 (e) P=0.382 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.500 (e) P=0.814 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.189 (e) P=0.378 |
|COCHRAN-ARMITAGE | (e) | P=0.207 |
|FISHER EXACT | (e) (e) | (e) P=0.437 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 1/69 (1%) 2/135 (1%) | 0/69 (0%) 0/65 (0%) 1/135 (1%) |
|ADJUSTED (b) | 3.8% 1.9% 1.7% | 0.0% 0.0% 1.0% |
|TERMINAL (d) | 1/26 (4%) 1/52 (2%) 2/118 (2%) | 0/59 (0%) 0/57 (0%) 1/102 (1%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) 736 (T) | --- --- 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.451N P=0.599N P=0.525N | P=0.399 (e) P=0.609 |
|INCIDENTAL TUMOR | P=0.451N P=0.599N P=0.525N | P=0.399 (e) P=0.609 |
|LOGISTIC REGRESSION | P=0.451N P=0.599N P=0.525N | P=0.399 (e) P=0.609 |
|COCHRAN-ARMITAGE | P=0.639 | P=0.423 |
|FISHER EXACT | P=0.748 P=0.731 | (e) P=0.662 |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05110 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NAPHTHALENE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 30 PPM | CONTROL 10 PPM 30 PPM |
| | | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/69 (0%) 0/135 (0%) | 0/69 (0%) 2/65 (3%) 0/135 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 3.5% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/52 (0%) 0/118 (0%) | 0/59 (0%) 2/57 (4%) 0/102 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- 736 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.429N P=0.231 (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.429N P=0.231 (e) |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.429N P=0.231 (e) |
|COCHRAN-ARMITAGE | (e) | P=0.394N |
|FISHER EXACT | (e) (e) | P=0.233 (e) |
|=================================================================================================================================|
| |
|Harderian Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 1/70 (1%) 1/69 (1%) 2/135 (1%) | 0/69 (0%) 2/65 (3%) 1/135 (1%) |
|ADJUSTED (b) | 3.8% 1.9% 1.7% | 0.0% 3.5% 1.0% |
|TERMINAL (d) | 1/26 (4%) 1/52 (2%) 2/118 (2%) | 0/59 (0%) 2/57 (4%) 1/102 (1%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) 736 (T) | --- 736 (T) 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.451N P=0.599N P=0.525N | P=0.671 P=0.231 P=0.609 |
|INCIDENTAL TUMOR | P=0.451N P=0.599N P=0.525N | P=0.671 P=0.231 P=0.609 |
|LOGISTIC REGRESSION | P=0.451N P=0.599N P=0.525N | P=0.671 P=0.231 P=0.609 |
|COCHRAN-ARMITAGE | P=0.639 | P=0.632N |
|FISHER EXACT | P=0.748 P=0.731 | P=0.233 P=0.662 |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05110 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NAPHTHALENE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 30 PPM | CONTROL 10 PPM 30 PPM |
| | | |
|=================================================================================================================================|
| |
|Intestine Small: Duodenum |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/69 (0%) 2/135 (1%) | 0/69 (0%) 1/65 (2%) 0/135 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 1.7% | 0.0% 1.8% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/52 (0%) 2/118 (2%) | 0/59 (0%) 1/57 (2%) 0/102 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 736 (T) | --- 736 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.303 (e) P=0.601 | P=0.601N P=0.493 (e) |
|INCIDENTAL TUMOR | P=0.303 (e) P=0.601 | P=0.601N P=0.493 (e) |
|LOGISTIC REGRESSION | P=0.303 (e) P=0.601 | P=0.601N P=0.493 (e) |
|COCHRAN-ARMITAGE | P=0.200 | P=0.577N |
|FISHER EXACT | (e) P=0.433 | P=0.485 (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/70 (4%) 10/33 (30%) 16/135 (12%) | 2/68 (3%) 2/12 (17%) 2/134 (1%) |
|ADJUSTED (b) | 9.3% 53.7% 13.6% | 3.4% 33.3% 1.8% |
|TERMINAL (d) | 1/26 (4%) 9/17 (53%) 16/118 (14%) | 2/59 (3%) 2/6 (33%) 1/101 (1%) |
|FIRST INCIDENCE (DAYS) | 382 536 736 (T) | 736 (T) 736 (T) 668 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.126N P=0.010 ** P=0.493 | P=0.276N P=0.023 * P=0.480N |
|INCIDENTAL TUMOR | P=0.282N P=0.001 ** P=0.260 | P=0.207N P=0.023 * P=0.401N |
|LOGISTIC REGRESSION | P=0.373N P<0.001 ** P=0.232 | P=0.227N P=0.023 * P=0.443N |
|COCHRAN-ARMITAGE | P=0.299 | P=0.220N |
|FISHER EXACT | P<0.001 ** P=0.059 | P=0.105 P=0.413N |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05110 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NAPHTHALENE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 30 PPM | CONTROL 10 PPM 30 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/70 (9%) 4/33 (12%) 7/135 (5%) | 0/68 (0%) 0/12 (0%) 1/134 (1%) |
|ADJUSTED (b) | 19.2% 19.1% 5.9% | 0.0% 0.0% 0.9% |
|TERMINAL (d) | 3/26 (12%) 3/17 (18%) 7/118 (6%) | 0/59 (0%) 0/6 (0%) 0/101 (0%) |
|FIRST INCIDENCE (DAYS) | 655 640 736 (T) | --- --- 714 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.006N** P=0.418N P=0.014N* | P=0.402 (e) P=0.613 |
|INCIDENTAL TUMOR | P=0.041N* P=0.473 P=0.135N | P=0.651 (e) P=0.814 |
|LOGISTIC REGRESSION | P=0.019N* P=0.527 P=0.048N* | P=0.481 (e) P=0.634 |
|COCHRAN-ARMITAGE | P=0.164N | P=0.481 |
|FISHER EXACT | P=0.404 P=0.256N | (e) P=0.663 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/70 (11%) 14/33 (42%) 23/135 (17%) | 2/68 (3%) 2/12 (17%) 3/134 (2%) |
|ADJUSTED (b) | 23.7% 71.6% 19.5% | 3.4% 33.3% 2.8% |
|TERMINAL (d) | 3/26 (12%) 12/17 (71%) 23/118 (19%) | 2/59 (3%) 2/6 (33%) 1/101 (1%) |
|FIRST INCIDENCE (DAYS) | 382 536 736 (T) | 736 (T) 736 (T) 668 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.008N** P=0.049 * P=0.201N | P=0.424N P=0.023 * P=0.615N |
|INCIDENTAL TUMOR | P=0.071N P=0.001 ** P=0.533 | P=0.268N P=0.023 * P=0.475N |
|LOGISTIC REGRESSION | P=0.070N P=0.001 ** P=0.530N | P=0.342N P=0.023 * P=0.577N |
|COCHRAN-ARMITAGE | P=0.539 | P=0.336N |
|FISHER EXACT | P<0.001 ** P=0.197 | P=0.105 P=0.547N |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05110 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NAPHTHALENE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 30 PPM | CONTROL 10 PPM 30 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/70 (11%) 14/33 (42%) 23/135 (17%) | 2/68 (3%) 2/12 (17%) 3/134 (2%) |
|ADJUSTED (b) | 23.7% 71.6% 19.5% | 3.4% 33.3% 2.8% |
|TERMINAL (d) | 3/26 (12%) 12/17 (71%) 23/118 (19%) | 2/59 (3%) 2/6 (33%) 1/101 (1%) |
|FIRST INCIDENCE (DAYS) | 382 536 736 (T) | 736 (T) 736 (T) 668 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.008N** P=0.049 * P=0.201N | P=0.424N P=0.023 * P=0.615N |
|INCIDENTAL TUMOR | P=0.071N P=0.001 ** P=0.533 | P=0.268N P=0.023 * P=0.475N |
|LOGISTIC REGRESSION | P=0.070N P=0.001 ** P=0.530N | P=0.342N P=0.023 * P=0.577N |
|COCHRAN-ARMITAGE | P=0.539 | P=0.336N |
|FISHER EXACT | P<0.001 ** P=0.197 | P=0.105 P=0.547N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/70 (10%) 15/69 (22%) 27/135 (20%) | 5/69 (7%) 2/65 (3%) 28/135 (21%) |
|ADJUSTED (b) | 25.7% 28.8% 22.7% | 8.3% 3.5% 25.6% |
|TERMINAL (d) | 6/26 (23%) 15/52 (29%) 26/118 (22%) | 4/59 (7%) 2/57 (4%) 22/102 (22%) |
|FIRST INCIDENCE (DAYS) | 714 736 (T) 656 | 729 736 (T) 471 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.274N P=0.529 P=0.441N | P<0.001 ** P=0.236N P=0.006 ** |
|INCIDENTAL TUMOR | P=0.386N P=0.454 P=0.555 | P<0.001 ** P=0.249N P=0.018 * |
|LOGISTIC REGRESSION | P=0.411N P=0.450 P=0.541 | P<0.001 ** P=0.233N P=0.010 * |
|COCHRAN-ARMITAGE | P=0.108 | P<0.001 ** |
|FISHER EXACT | P=0.047 * P=0.049 * | P=0.246N P=0.009 ** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05110 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NAPHTHALENE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 30 PPM | CONTROL 10 PPM 30 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 3/69 (4%) 7/135 (5%) | 0/69 (0%) 0/65 (0%) 1/135 (1%) |
|ADJUSTED (b) | 0.0% 5.5% 5.9% | 0.0% 0.0% 1.0% |
|TERMINAL (d) | 0/26 (0%) 2/52 (4%) 7/118 (6%) | 0/59 (0%) 0/57 (0%) 1/102 (1%) |
|FIRST INCIDENCE (DAYS) | --- 629 736 (T) | --- --- 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.256 P=0.246 P=0.222 | P=0.399 (e) P=0.609 |
|INCIDENTAL TUMOR | P=0.235 P=0.153 P=0.222 | P=0.399 (e) P=0.609 |
|LOGISTIC REGRESSION | P=0.180 P=0.176 P=0.222 | P=0.399 (e) P=0.609 |
|COCHRAN-ARMITAGE | P=0.079 | P=0.423 |
|FISHER EXACT | P=0.120 P=0.051 | (e) P=0.662 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/70 (10%) 17/69 (25%) 31/135 (23%) | 5/69 (7%) 2/65 (3%) 29/135 (21%) |
|ADJUSTED (b) | 25.7% 31.9% 26.0% | 8.3% 3.5% 26.5% |
|TERMINAL (d) | 6/26 (23%) 16/52 (31%) 30/118 (25%) | 4/59 (7%) 2/57 (4%) 23/102 (23%) |
|FIRST INCIDENCE (DAYS) | 714 629 656 | 729 736 (T) 471 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.363N P=0.384 P=0.580N | P<0.001 ** P=0.236N P=0.004 ** |
|INCIDENTAL TUMOR | P=0.494N P=0.270 P=0.416 | P<0.001 ** P=0.249N P=0.013 * |
|LOGISTIC REGRESSION | P=0.530 P=0.212 P=0.394 | P<0.001 ** P=0.233N P=0.007 ** |
|COCHRAN-ARMITAGE | P=0.054 | P<0.001 ** |
|FISHER EXACT | P=0.019 * P=0.016 * | P=0.246N P=0.006 ** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05110 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NAPHTHALENE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 30 PPM | CONTROL 10 PPM 30 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/69 (0%) 0/135 (0%) | 2/69 (3%) 1/65 (2%) 3/135 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 3.4% 1.8% 2.6% |
|TERMINAL (d) | 0/26 (0%) 0/52 (0%) 0/118 (0%) | 2/59 (3%) 1/57 (2%) 0/102 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 736 (T) 736 (T) 659 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.608N P=0.512N P=0.603N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.368N P=0.512N P=0.385N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.566N P=0.512N P=0.352N |
|COCHRAN-ARMITAGE | (e) | P=0.565N |
|FISHER EXACT | (e) (e) | P=0.523N P=0.550N |
|=================================================================================================================================|
| |
|Nose |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/69 (0%) 0/135 (0%) | 0/69 (0%) 2/65 (3%) 0/135 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 3.5% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/52 (0%) 0/118 (0%) | 0/59 (0%) 2/57 (4%) 0/102 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- 736 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.429N P=0.231 (e) |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.429N P=0.231 (e) |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.429N P=0.231 (e) |
|COCHRAN-ARMITAGE | (e) | P=0.394N |
|FISHER EXACT | (e) (e) | P=0.233 (e) |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05110 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NAPHTHALENE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 30 PPM | CONTROL 10 PPM 30 PPM |
| | | |
|=================================================================================================================================|
| |
|Ovary |
| Cystadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 2/69 (3%) 0/14 (0%) 4/131 (3%) |
|ADJUSTED (b) | | 3.4% 0.0% 4.0% |
|TERMINAL (d) | | 2/59 (3%) 0/12 (0%) 4/101 (4%) |
|FIRST INCIDENCE (DAYS) | | 736 (T) --- 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.499 P=0.621N P=0.598 |
|INCIDENTAL TUMOR | | P=0.499 P=0.621N P=0.598 |
|LOGISTIC REGRESSION | | P=0.499 P=0.621N P=0.598 |
|COCHRAN-ARMITAGE | | P=0.548 |
|FISHER EXACT | | P=0.689N P=0.659 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/70 (6%) 3/69 (4%) 1/135 (1%) | 0/69 (0%) 0/65 (0%) 1/135 (1%) |
|ADJUSTED (b) | 15.4% 5.8% 0.8% | 0.0% 0.0% 1.0% |
|TERMINAL (d) | 4/26 (15%) 3/52 (6%) 1/118 (1%) | 0/59 (0%) 0/57 (0%) 1/102 (1%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) 736 (T) | --- --- 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002N** P=0.165N P=0.001N** | P=0.399 (e) P=0.609 |
|INCIDENTAL TUMOR | P=0.002N** P=0.165N P=0.001N** | P=0.399 (e) P=0.609 |
|LOGISTIC REGRESSION | P=0.002N** P=0.165N P=0.001N** | P=0.399 (e) P=0.609 |
|COCHRAN-ARMITAGE | P=0.030N* | P=0.423 |
|FISHER EXACT | P=0.508N P=0.047N* | (e) P=0.662 |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05110 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NAPHTHALENE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 30 PPM | CONTROL 10 PPM 30 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 11/70 (16%) 6/69 (9%) 4/135 (3%) | 1/69 (1%) 1/65 (2%) 2/135 (1%) |
|ADJUSTED (b) | 31.0% 10.4% 3.2% | 1.7% 1.7% 1.8% |
|TERMINAL (d) | 4/26 (15%) 2/52 (4%) 2/118 (2%) | 1/59 (2%) 0/57 (0%) 1/102 (1%) |
|FIRST INCIDENCE (DAYS) | 558 536 611 | 736 (T) 718 623 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001N** P=0.016N* P<0.001N** | P=0.614 P=0.753 P=0.698 |
|INCIDENTAL TUMOR | P=0.003N** P=0.322N P=0.001N** | P=0.593N P=0.725 P=0.669 |
|LOGISTIC REGRESSION | P=0.001N** P=0.189N P=0.001N** | P=0.649 P=0.748 P=0.725 |
|COCHRAN-ARMITAGE | P=0.001N** | P=0.649 |
|FISHER EXACT | P=0.158N P=0.002N** | P=0.737 P=0.735 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 2/70 (3%) 0/69 (0%) 1/135 (1%) | 0/69 (0%) 0/65 (0%) 0/135 (0%) |
|ADJUSTED (b) | 5.5% 0.0% 0.8% | 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/52 (0%) 0/118 (0%) | 0/59 (0%) 0/57 (0%) 0/102 (0%) |
|FIRST INCIDENCE (DAYS) | 589 --- 493 | --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.189N P=0.152N P=0.139N | (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.621N P=0.432N P=0.681N | (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.384N P=0.199N P=0.407N | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.298N | (e) |
|FISHER EXACT | P=0.252N P=0.269N | (e) (e) |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05110 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NAPHTHALENE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 30 PPM | CONTROL 10 PPM 30 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 23/70 (33%) 11/69 (16%) 8/135 (6%) | 1/69 (1%) 2/65 (3%) 4/135 (3%) |
|ADJUSTED (b) | 57.8% 19.1% 6.4% | 1.7% 3.4% 3.5% |
|TERMINAL (d) | 10/26 (38%) 6/52 (12%) 4/118 (3%) | 1/59 (2%) 0/57 (0%) 2/102 (2%) |
|FIRST INCIDENCE (DAYS) | 558 536 493 | 736 (T) 669 623 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001N** P<0.001N** P<0.001N** | P=0.372 P=0.490 P=0.397 |
|INCIDENTAL TUMOR | P<0.001N** P=0.015N* P<0.001N** | P=0.514 P=0.426 P=0.353 |
|LOGISTIC REGRESSION | P<0.001N** P=0.003N** P<0.001N** | P=0.411 P=0.479 P=0.428 |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.411 |
|FISHER EXACT | P=0.016N* P<0.001N** | P=0.477 P=0.450 |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, or Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 19/70 (27%) 8/69 (12%) 8/135 (6%) | 1/69 (1%) 2/65 (3%) 3/135 (2%) |
|ADJUSTED (b) | 47.2% 13.8% 6.4% | 1.7% 3.4% 2.6% |
|TERMINAL (d) | 6/26 (23%) 3/52 (6%) 4/118 (3%) | 1/59 (2%) 0/57 (0%) 1/102 (1%) |
|FIRST INCIDENCE (DAYS) | 558 536 493 | 736 (T) 669 623 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001N** P<0.001N** P<0.001N** | P=0.526 P=0.490 P=0.537 |
|INCIDENTAL TUMOR | P<0.001N** P=0.058N P<0.001N** | P=0.570N P=0.426 P=0.486 |
|LOGISTIC REGRESSION | P<0.001N** P=0.009N** P<0.001N** | P=0.560 P=0.479 P=0.562 |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.561 |
|FISHER EXACT | P=0.017N* P<0.001N** | P=0.477 P=0.584 |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05110 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NAPHTHALENE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 30 PPM | CONTROL 10 PPM 30 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 6/70 (9%) 2/69 (3%) 3/135 (2%) | 0/69 (0%) 1/65 (2%) 1/135 (1%) |
|ADJUSTED (b) | 17.7% 3.7% 2.5% | 0.0% 1.7% 0.8% |
|TERMINAL (d) | 2/26 (8%) 1/52 (2%) 2/118 (2%) | 0/59 (0%) 0/57 (0%) 0/102 (0%) |
|FIRST INCIDENCE (DAYS) | 652 692 696 | --- 669 627 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.005N** P=0.031N* P=0.001N** | P=0.597 P=0.497 P=0.630 |
|INCIDENTAL TUMOR | P=0.164N P=0.228N P=0.157N | P=0.696N P=0.443 P=0.581 |
|LOGISTIC REGRESSION | P=0.109N P=0.054N P=0.006N** | P=0.601 P=0.491 P=0.629 |
|COCHRAN-ARMITAGE | P=0.048N* | P=0.606 |
|FISHER EXACT | P=0.142N P=0.044N* | P=0.485 P=0.662 |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/69 (0%) 0/18 (0%) 0/135 (0%) | 0/67 (0%) 0/13 (0%) 3/134 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 0.0% 2.7% |
|TERMINAL (d) | 0/26 (0%) 0/7 (0%) 0/118 (0%) | 0/59 (0%) 0/9 (0%) 1/101 (1%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- --- 658 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.122 (e) P=0.250 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.274 (e) P=0.387 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.181 (e) P=0.273 |
|COCHRAN-ARMITAGE | (e) | P=0.181 |
|FISHER EXACT | (e) (e) | (e) P=0.294 |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05110 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NAPHTHALENE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 30 PPM | CONTROL 10 PPM 30 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/69 (0%) 0/135 (0%) | 2/69 (3%) 0/65 (0%) 1/135 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 3.3% 0.0% 1.0% |
|TERMINAL (d) | 0/26 (0%) 0/52 (0%) 0/118 (0%) | 1/59 (2%) 0/57 (0%) 1/102 (1%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 662 --- 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.321N P=0.247N P=0.306N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.222N P=0.275N P=0.219N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.291N P=0.251N P=0.276N |
|COCHRAN-ARMITAGE | (e) | P=0.290N |
|FISHER EXACT | (e) (e) | P=0.263N P=0.265N |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/69 (0%) 0/135 (0%) | 2/69 (3%) 0/65 (0%) 0/135 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 3.3% 0.0% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/52 (0%) 0/118 (0%) | 1/59 (2%) 0/57 (0%) 0/102 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | 662 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.098N P=0.247N P=0.123N |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.043N* P=0.275N P=0.056N |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.088N P=0.251N P=0.108N |
|COCHRAN-ARMITAGE | (e) | P=0.088N |
|FISHER EXACT | (e) (e) | P=0.263N P=0.113N |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05110 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NAPHTHALENE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 30 PPM | CONTROL 10 PPM 30 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 1/69 (1%) 2/65 (3%) 0/135 (0%) |
|ADJUSTED (b) | | 1.7% 3.5% 0.0% |
|TERMINAL (d) | | 1/59 (2%) 2/57 (4%) 0/102 (0%) |
|FIRST INCIDENCE (DAYS) | | 736 (T) 736 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.187N P=0.488 P=0.391N |
|INCIDENTAL TUMOR | | P=0.187N P=0.488 P=0.391N |
|LOGISTIC REGRESSION | | P=0.187N P=0.488 P=0.391N |
|COCHRAN-ARMITAGE | | P=0.159N |
|FISHER EXACT | | P=0.477 P=0.338N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # |
|----------- | | |
|OVERALL (a) | | 1/69 (1%) 3/65 (5%) 1/135 (1%) |
|ADJUSTED (b) | | 1.7% 5.3% 1.0% |
|TERMINAL (d) | | 1/59 (2%) 3/57 (5%) 1/102 (1%) |
|FIRST INCIDENCE (DAYS) | | 736 (T) 736 (T) 736 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.323N P=0.294 P=0.634N |
|INCIDENTAL TUMOR | | P=0.323N P=0.294 P=0.634N |
|LOGISTIC REGRESSION | | P=0.323N P=0.294 P=0.634N |
|COCHRAN-ARMITAGE | | P=0.274N |
|FISHER EXACT | | P=0.287 P=0.563N |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05110 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NAPHTHALENE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 30 PPM | CONTROL 10 PPM 30 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/69 (0%) 1/135 (1%) | 0/69 (0%) 0/65 (0%) 5/135 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.8% | 0.0% 0.0% 4.4% |
|TERMINAL (d) | 0/26 (0%) 0/52 (0%) 1/118 (1%) | 0/59 (0%) 0/57 (0%) 2/102 (2%) |
|FIRST INCIDENCE (DAYS) | --- --- 736 (T) | --- --- 648 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.524 (e) P=0.797 | P=0.030 * (e) P=0.118 |
|INCIDENTAL TUMOR | P=0.524 (e) P=0.797 | P=0.084 (e) P=0.212 |
|LOGISTIC REGRESSION | P=0.524 (e) P=0.797 | P=0.034 * (e) P=0.127 |
|COCHRAN-ARMITAGE | P=0.418 | P=0.034 * |
|FISHER EXACT | (e) P=0.659 | (e) P=0.124 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/69 (0%) 1/135 (1%) | 0/69 (0%) 0/65 (0%) 5/135 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.8% | 0.0% 0.0% 4.4% |
|TERMINAL (d) | 0/26 (0%) 0/52 (0%) 1/118 (1%) | 0/59 (0%) 0/57 (0%) 2/102 (2%) |
|FIRST INCIDENCE (DAYS) | --- --- 736 (T) | --- --- 648 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.524 (e) P=0.797 | P=0.030 * (e) P=0.118 |
|INCIDENTAL TUMOR | P=0.524 (e) P=0.797 | P=0.084 (e) P=0.212 |
|LOGISTIC REGRESSION | P=0.524 (e) P=0.797 | P=0.034 * (e) P=0.127 |
|COCHRAN-ARMITAGE | P=0.418 | P=0.034 * |
|FISHER EXACT | (e) P=0.659 | (e) P=0.124 |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05110 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NAPHTHALENE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 30 PPM | CONTROL 10 PPM 30 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/70 (6%) 3/69 (4%) 4/135 (3%) | 8/69 (12%) 8/65 (12%) 14/135 (10%) |
|ADJUSTED (b) | 12.5% 5.8% 3.3% | 12.4% 14.0% 12.2% |
|TERMINAL (d) | 2/26 (8%) 3/52 (6%) 2/118 (2%) | 3/59 (5%) 8/57 (14%) 7/102 (7%) |
|FIRST INCIDENCE (DAYS) | 282 736 (T) 280 | 574 736 (T) 423 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.057N P=0.205N P=0.059N | P=0.520N P=0.568 P=0.557N |
|INCIDENTAL TUMOR | P=0.349N P=0.374N P=0.623N | P=0.225N P=0.410 P=0.285N |
|LOGISTIC REGRESSION | P=0.218N P=0.389N P=0.332N | P=0.293N P=0.331 P=0.396N |
|COCHRAN-ARMITAGE | P=0.237N | P=0.417N |
|FISHER EXACT | P=0.508N P=0.272N | P=0.554 P=0.481N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 4/70 (6%) 3/69 (4%) 4/135 (3%) | 8/69 (12%) 8/65 (12%) 14/135 (10%) |
|ADJUSTED (b) | 12.5% 5.8% 3.3% | 12.4% 14.0% 12.2% |
|TERMINAL (d) | 2/26 (8%) 3/52 (6%) 2/118 (2%) | 3/59 (5%) 8/57 (14%) 7/102 (7%) |
|FIRST INCIDENCE (DAYS) | 282 736 (T) 280 | 574 736 (T) 423 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.057N P=0.205N P=0.059N | P=0.520N P=0.568 P=0.557N |
|INCIDENTAL TUMOR | P=0.349N P=0.374N P=0.623N | P=0.225N P=0.410 P=0.285N |
|LOGISTIC REGRESSION | P=0.218N P=0.389N P=0.332N | P=0.293N P=0.331 P=0.396N |
|COCHRAN-ARMITAGE | P=0.237N | P=0.417N |
|FISHER EXACT | P=0.508N P=0.272N | P=0.554 P=0.481N |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05110 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NAPHTHALENE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 30 PPM | CONTROL 10 PPM 30 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/69 (0%) 0/135 (0%) | 0/69 (0%) 0/65 (0%) 2/135 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 0.0% 1.7% |
|TERMINAL (d) | 0/26 (0%) 0/52 (0%) 0/118 (0%) | 0/59 (0%) 0/57 (0%) 0/102 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- --- 427 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.197 (e) P=0.382 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.500 (e) P=0.814 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.189 (e) P=0.378 |
|COCHRAN-ARMITAGE | (e) | P=0.207 |
|FISHER EXACT | (e) (e) | (e) P=0.437 |
|=================================================================================================================================|
| |
|All Organs |
| Osteosarcoma or Osteoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 0/70 (0%) 0/69 (0%) 0/135 (0%) | 0/69 (0%) 0/65 (0%) 2/135 (1%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% | 0.0% 0.0% 1.7% |
|TERMINAL (d) | 0/26 (0%) 0/52 (0%) 0/118 (0%) | 0/59 (0%) 0/57 (0%) 0/102 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- | --- --- 427 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) | P=0.197 (e) P=0.382 |
|INCIDENTAL TUMOR | (e) (e) (e) | P=0.500 (e) P=0.814 |
|LOGISTIC REGRESSION | (e) (e) (e) | P=0.189 (e) P=0.378 |
|COCHRAN-ARMITAGE | (e) | P=0.207 |
|FISHER EXACT | (e) (e) | (e) P=0.437 |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05110 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NAPHTHALENE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 30 PPM | CONTROL 10 PPM 30 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 15/70 (21%) 24/69 (35%) 44/135 (33%) | 15/69 (22%) 7/65 (11%) 41/135 (30%) |
|ADJUSTED (b) | 48.6% 45.2% 36.6% | 24.6% 12.3% 36.6% |
|TERMINAL (d) | 11/26 (42%) 23/52 (44%) 42/118 (36%) | 13/59 (22%) 7/57 (12%) 32/102 (31%) |
|FIRST INCIDENCE (DAYS) | 382 536 504 | 662 736 (T) 471 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.052N P=0.310N P=0.075N | P=0.006 ** P=0.063N P=0.064 |
|INCIDENTAL TUMOR | P=0.232N P=0.583 P=0.416N | P=0.031 * P=0.068N P=0.180 |
|LOGISTIC REGRESSION | P=0.346N P=0.393 P=0.534N | P=0.015 * P=0.066N P=0.112 |
|COCHRAN-ARMITAGE | P=0.124 | P=0.018 * |
|FISHER EXACT | P=0.059 P=0.064 | P=0.069N P=0.126 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 26/70 (37%) 16/69 (23%) 32/135 (24%) | 12/69 (17%) 18/65 (28%) 32/135 (24%) |
|ADJUSTED (b) | 60.1% 27.4% 25.1% | 18.7% 30.5% 25.5% |
|TERMINAL (d) | 9/26 (35%) 10/52 (19%) 23/118 (19%) | 7/59 (12%) 16/57 (28%) 11/102 (11%) |
|FIRST INCIDENCE (DAYS) | 282 536 182 | 574 669 423 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001N** P<0.001N** P<0.001N** | P=0.201 P=0.135 P=0.158 |
|INCIDENTAL TUMOR | P=0.152N P=0.080N P=0.112N | P=0.336N P=0.056 P=0.548 |
|LOGISTIC REGRESSION | P=0.021N* P=0.018N* P=0.006N** | P=0.525 P=0.036 * P=0.315 |
|COCHRAN-ARMITAGE | P=0.058N | P=0.302 |
|FISHER EXACT | P=0.054N P=0.032N* | P=0.111 P=0.197 |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05110 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- NAPHTHALENE
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 10 PPM 30 PPM | CONTROL 10 PPM 30 PPM |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # | # # # |
|----------- | | |
|OVERALL (a) | 36/70 (51%) 36/69 (52%) 67/135 (50%) | 23/69 (33%) 22/65 (34%) 64/135 (47%) |
|ADJUSTED (b) | 79.7% 62.0% 51.9% | 35.4% 37.3% 49.9% |
|TERMINAL (d) | 17/26 (65%) 30/52 (58%) 56/118 (47%) | 17/59 (29%) 20/57 (35%) 38/102 (37%) |
|FIRST INCIDENCE (DAYS) | 282 536 182 | 574 669 423 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001N** P<0.001N** P<0.001N** | P=0.006 ** P=0.557N P=0.025 * |
|INCIDENTAL TUMOR | P=0.084N P=0.190N P=0.179N | P=0.108 P=0.447 P=0.153 |
|LOGISTIC REGRESSION | P=0.026N* P=0.111N P=0.038N* | P=0.041 * P=0.374 P=0.070 |
|COCHRAN-ARMITAGE | P=0.410N | P=0.016 * |
|FISHER EXACT | P=0.533 P=0.461N | P=0.548 P=0.037 * |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).