TDMS Study 05110-01 Pathology Tables
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
Facility: Northrop Services, Inc.
Chemical CAS #: 91-20-3
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 9|
| 6| 6| 6| 6| 6| 5| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + A + + + + + + + + + A + + + + + + A|
Serosa, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + A|
Serosa, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Serosa, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + A|
Serosa, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Cyst | |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 3 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 1 2 1 1 |
Inflammation, Chronic, Multifocal | 2 |
Pigmentation, Focal | 2 |
__________________________________________________________________________|
Mesentery | + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation, Chronic, Multifocal | |
Inflammation, Focal, Granulomatous | 2 |
Fat, Necrosis | 2 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | |
Atrophy, Multifocal | |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 2 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 |
Inflammation, Multifocal | |
Duct, Dilatation | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 9|
| 6| 6| 6| 6| 6| 5| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 1 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + A + + + + + + M|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + M|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + M|
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Valve, Pigmentation, Focal | |
Valve, Pigmentation, Multifocal | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia, Multifocal | 3 4 3 3 3 3 3 3 3 3 2 3 3 2 3 3 2 2 3 3 3 3 3 3|
Capsule, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + M + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Congestion, Multifocal | |
Cyst | |
Degeneration, Focal | |
Focal Cellular Change | 2 X |
Pigmentation, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Focal | |
__________________________________________________________________________|
Pituitary Gland | M + + M + + + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 2 |
Follicle, Dilatation, Focal | 2 |
Follicular Cell, Hyperplasia, Focal | |
Follicular Cell, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 9|
| 6| 6| 6| 6| 6| 5| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Multifocal | |
Follicular Cell, Hypertrophy, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X 3 X |
Cyst, Multifocal | X |
Pigmentation | |
Follicle, Hemorrhage, Focal | 2 3 2 |
Interstitium, Hyperplasia | |
__________________________________________________________________________|
Oviduct | |
Mucosa, Vacuolization Cytoplasmic, | |
Multifocal | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | |
Endometrium, Hyperplasia, Cystic | 3 3 3 2 3 3 3 2 3 3 3 3 3 2 3 3 2 3 3 3 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Fibrous Osteodystrophy, Multifocal | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia | 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + M M M M M + M + + M + M|
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +|
Edema | 3|
Hyperplasia, Lymphoid | |
Pigmentation | 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + M + + + + + M + + + + + + + M M|
Angiectasis | |
Hyperplasia, Lymphoid | |
Pigmentation | 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + M|
Erythrophagocytosis | |
Giant Cell, Multifocal | 2 2 |
Hemorrhage | 3 2 2 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 9|
| 6| 6| 6| 6| 6| 5| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Multifocal, Plasma Cell | |
Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hematopoietic Cell Proliferation | 3 2|
Hyperplasia, Lymphoid | 3 2 2 |
Hyperplasia, Plasma Cell | |
Capsule, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + M|
Angiectasis | |
Cyst, Multiple | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Infiltration | |
Cellular, Multifocal, Lymphocyte | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy, Focal | |
Fibrous Osteodystrophy, Multifocal | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Focal, Osseous | 2 |
Mineralization, Focal | 2 |
Mineralization, Multifocal | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 |
Infiltration Cellular, Histiocyte | |
Inflammation | |
Alveolar Epithelium, Hyperplasia | 3 2 |
Glands, Inflammation | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 7| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 9|
| 6| 6| 6| 6| 6| 5| 6| 8| 9| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Inflammation, Multifocal, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Pigmentation | |
Bilateral, Lens, Cataract | |
Cornea, Degeneration | |
Optic Nerve, Degeneration | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Multifocal | |
Infarct, Focal | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2|
Metaplasia, Focal, Osseous | 2 |
Nephropathy | |
Capsule, Inflammation, Chronic, | |
Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 0| 6| 0| 2| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic, | |
Multifocal | 3 |
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic, | |
Multifocal | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic, | |
Multifocal | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Chronic, | |
Multifocal | 3 |
__________________________________________________________________________|
Liver | + + + A + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Cyst | X |
Hematopoietic Cell Proliferation, | |
Multifocal | 1 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 3 2 3 2 3 |
Inflammation, Chronic, Multifocal | 2 |
Pigmentation, Focal | |
__________________________________________________________________________|
Mesentery | + + + |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Inflammation, Chronic, Multifocal | 3 |
Inflammation, Focal, Granulomatous | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 4 |
Atrophy, Multifocal | |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 2 2 2 2 |
Inflammation, Multifocal | 3 2 |
Duct, Dilatation | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 0| 6| 0| 2| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 1 2 2 2 2 2 3 2 2 3 2 1|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Valve, Pigmentation, Focal | 2 |
Valve, Pigmentation, Multifocal | 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + M + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia, Multifocal | 3 3 2 2 3 3 3 3 3 3 3 2 3 3 3 2 3 2 3 3 3 3 3|
Capsule, Inflammation, Chronic, | |
Multifocal | 3 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + M + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Congestion, Multifocal | 2 |
Cyst | X |
Degeneration, Focal | |
Focal Cellular Change | |
Pigmentation, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Focal | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + M + + + M + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | |
Follicle, Dilatation, Focal | |
Follicular Cell, Hyperplasia, Focal | |
Follicular Cell, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 0| 6| 0| 2| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Multifocal | 2 |
Follicular Cell, Hypertrophy, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Cyst, Multifocal | |
Pigmentation | 2 |
Follicle, Hemorrhage, Focal | |
Interstitium, Hyperplasia | 2 |
__________________________________________________________________________|
Oviduct | + + |
Mucosa, Vacuolization Cytoplasmic, | |
Multifocal | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | |
Endometrium, Hyperplasia, Cystic | 3 2 3 3 2 2 3 3 2 2 3 3 3 3 2 2 3 3 3 2 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Fibrous Osteodystrophy, Multifocal | |
Hyperplasia, Lymphoid | 2 3 |
Hyperplasia | 3 |
Myelofibrosis | 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + M + + M M + M M + + M M + + + M + M M|
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M|
Edema | |
Hyperplasia, Lymphoid | 3 3 |
Pigmentation | 2 2 3 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + + + + + + + M + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia, Lymphoid | 3 |
Pigmentation | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + A + + + + + + + + + + + + + + + + + + + +|
Erythrophagocytosis | |
Giant Cell, Multifocal | 2 2 2 2 2 2|
Hemorrhage | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 0| 6| 0| 2| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Multifocal, Plasma Cell | |
Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Spleen | + + + M + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 3 3 3|
Hyperplasia, Plasma Cell | |
Capsule, Inflammation, Chronic, | |
Multifocal | 3 |
__________________________________________________________________________|
Thymus | + M + M + + + + + + + + + + + M + + + + + + + +|
Angiectasis | 2 |
Cyst, Multiple | X |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Infiltration | |
Cellular, Multifocal, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy, Focal | 2 |
Fibrous Osteodystrophy, Multifocal | 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Focal, Osseous | |
Mineralization, Focal | 2 1 |
Mineralization, Multifocal | 1 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 3 2 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation | 2 |
Alveolar Epithelium, Hyperplasia | |
Glands, Inflammation | |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 1| 7| 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 4| 3| 4| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 0| 6| 0| 2| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Inflammation, Multifocal, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Pigmentation | |
Bilateral, Lens, Cataract | 3 |
Cornea, Degeneration | |
Optic Nerve, Degeneration | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Multifocal | 2 |
Infarct, Focal | |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Metaplasia, Focal, Osseous | |
Nephropathy | |
Capsule, Inflammation, Chronic, | |
Multifocal | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 2 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 3 2|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| |
| 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 8| 8| 1| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + + + + + M + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + +| 65 |
Serosa, Inflammation, Chronic, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +| 66 |
Serosa, Inflammation, Chronic, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + M + + + + + + + + + + + + + + + +| 66 |
Serosa, Inflammation, Chronic, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + +| 65 |
Serosa, Inflammation, Chronic, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + +| 68 |
Basophilic Focus | X | 1 |
Cyst | | 1 |
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 | 5 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 2 | 16 1.9|
Inflammation, Chronic, Multifocal | | 2 2.0|
Pigmentation, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 6 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
Inflammation, Chronic, Multifocal | | 1 3.0|
Inflammation, Focal, Granulomatous | | 1 2.0|
Fat, Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + +| 69 |
Atrophy, Diffuse | 4 | 2 4.0|
Atrophy, Multifocal | 2 | 1 2.0|
Infiltration Cellular, Focal, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| |
| 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 8| 8| 1| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Lymphocyte | | 3 1.3|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 2 2 2 2 2 2| 18 2.0|
Inflammation, Multifocal | 2 | 3 2.3|
Duct, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + M + + + + + + + + + + + + + + + +| 68 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 3 1.3|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 2 2 2 2 2 2 2 | 40 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + +| 67 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + +| 69 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Valve, Pigmentation, Focal | 2 2 | 3 2.0|
Valve, Pigmentation, Multifocal | | 7 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + M + + + + + + + + + + + + + + + +| 66 |
Capsule, Hyperplasia, Multifocal | 3 2 3 3 3 3 2 2 3 3 2 3 3 3 3 3 3 2 2| 66 2.8|
Capsule, Inflammation, Chronic, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + M + + + + + + + + + + + + + + + +| 66 |
Accessory Adrenal Cortical Nodule | | 1 |
Congestion, Multifocal | | 1 2.0|
Cyst | | 1 |
Degeneration, Focal | 3 | 1 3.0|
Focal Cellular Change | | 2 2.0|
Pigmentation, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + M + + + + M + + M + + + + + + + +| 64 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +| 69 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| |
| 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 8| 8| 1| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + +| 68 |
Cyst, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + + + + + + + + + + M + +| 61 |
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 2 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +| 69 |
Inflammation, Acute, Focal | | 1 2.0|
Follicle, Dilatation, Focal | 2 | 2 2.0|
Follicular Cell, Hyperplasia, Focal | 2 2 2 | 3 2.0|
Follicular Cell, Hyperplasia, | | |
Multifocal | | 1 2.0|
Follicular Cell, Hypertrophy, | | |
Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + +| 69 |
Cyst | X X | 11 3.0|
Cyst, Multifocal | | 1 |
Pigmentation | | 1 2.0|
Follicle, Hemorrhage, Focal | | 3 2.3|
Interstitium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Oviduct | | 2 |
Mucosa, Vacuolization Cytoplasmic, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + +| 69 |
Angiectasis, Multifocal | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 3 3 4 2 3 3 2 2 3 3 2 2 4 3 3 3 3 4| 61 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +| 69 |
Angiectasis | | 1 3.0|
Fibrous Osteodystrophy, Multifocal | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 | 4 2.3|
Hyperplasia | | 2 3.0|
Myelofibrosis | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +| 69 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| |
| 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 8| 8| 1| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + M + + + M + + + + + + + + + + +| 46 |
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + +| 66 |
Edema | | 1 3.0|
Hyperplasia, Lymphoid | | 2 3.0|
Pigmentation | 2 2 2| 15 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + + + + + + + M + + + + + + + +| 60 |
Angiectasis | | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
Pigmentation | 2 2 | 8 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + +| 67 |
Erythrophagocytosis | 2 2 | 2 2.0|
Giant Cell, Multifocal | 2 2 2 2 2 2 2 2 2 | 17 2.0|
Hemorrhage | 2 | 4 2.3|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Hyperplasia, Multifocal, Plasma Cell | 2 | 1 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + +| 67 |
Hematopoietic Cell Proliferation | 3 | 4 2.8|
Hyperplasia, Lymphoid | 2 3 3 | 9 2.7|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Capsule, Inflammation, Chronic, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + +| 64 |
Angiectasis | | 1 2.0|
Cyst, Multiple | | 1 |
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + +| 69 |
Hyperplasia, Focal | 3 3 | 2 3.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + +| 69 |
Subcutaneous Tissue, Infiltration | | |
Cellular, Multifocal, Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| |
| 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 8| 8| 1| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + +| 69 |
Fibrous Osteodystrophy, Focal | 2 X | 3 2.0|
Fibrous Osteodystrophy, Multifocal | 2 2 2 3| 7 2.2|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + +| 69 |
Metaplasia, Focal, Osseous | | 1 2.0|
Mineralization, Focal | | 3 1.7|
Mineralization, Multifocal | 2 2 2 2 2 | 34 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + +| 69 |
Congestion | 3 2 | 2 2.5|
Hemorrhage | | 1 1.0|
Infiltration Cellular, Lymphocyte | 3 | 11 2.2|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation | 1 2 | 3 1.7|
Alveolar Epithelium, Hyperplasia | 2 | 3 2.3|
Glands, Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + +| 69 |
Hemorrhage | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
Inflammation | 2| 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + +| 69 |
Glands, Inflammation, Multifocal, | | |
Suppurative | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Pigmentation | 4 | 1 4.0|
Bilateral, Lens, Cataract | | 1 3.0|
Cornea, Degeneration | 4 | 1 4.0|
Optic Nerve, Degeneration | 4 | 1 4.0|
Retina, Atrophy | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| |
| 4| 4| 4| 4| 4| 6| 3| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 6| 8| 8| 8| 1| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + +| 69 |
Congestion, Multifocal | | 1 2.0|
Infarct, Focal | | 1 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 2 1.5|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 2 2 2 3 2 2 2 2 2 2 2| 45 2.0|
Metaplasia, Focal, Osseous | | 1 2.0|
Nephropathy | 2 1 2 | 3 1.7|
Capsule, Inflammation, Chronic, | | |
Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + M| 67 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 4 1.8|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 2 2 2 3 2 2 2 2 2 2 2 | 47 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 1| 5| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 1| 4| 4| 6| 2| 8| 4| 4| 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4|
| 8| 4| 4| 9| 7| 6| 4| 4| 4| 4| 4| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
10 PPM | 9| 9| 9| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 1| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 2| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Gallbladder | |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | + |
Hyperplasia, Focal, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
__________________________________________________________________________|
Liver | + + + |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Necrosis, Multifocal | |
__________________________________________________________________________|
Pancreas | + |
__________________________________________________________________________|
Salivary Glands | |
Infiltration Cellular, Focal, | |
Lymphocyte | |
__________________________________________________________________________|
Stomach | + |
__________________________________________________________________________|
Stomach, Forestomach | + |
__________________________________________________________________________|
Stomach, Glandular | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
Mineralization, Multifocal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
Capsule, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
__________________________________________________________________________|
Islets, Pancreatic | |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | + |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + +|
Cyst | X X X |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 1| 5| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 1| 4| 4| 6| 2| 8| 4| 4| 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4|
| 8| 4| 4| 9| 7| 6| 4| 4| 4| 4| 4| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
10 PPM | 9| 9| 9| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 1| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 2| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst, Multifocal | |
Hematocyst, Focal | X X|
__________________________________________________________________________|
Oviduct | + |
Mucosa, Hyperplasia, Cystic | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + |
Angiectasis, Multifocal | |
Dilatation | 2 3 |
Endometrium, Hyperplasia, Cystic | 2 3 3 3 3 2 3 2 2 2 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Bronchial | |
__________________________________________________________________________|
Lymph Node, Mandibular | + |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
__________________________________________________________________________|
Spleen | + + |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Thymus | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | |
__________________________________________________________________________|
Skin | + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
Mineralization, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 3 2 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Granulomatous | 2 2 2 2 2 2 3 2 2 2 2 2 2 2 |
Inflammation | 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 1| 5| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 1| 4| 4| 6| 2| 8| 4| 4| 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 4| 4| 6| 4| 4| 4|
| 8| 4| 4| 9| 7| 6| 4| 4| 4| 4| 4| 4| 4| 7| 6| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
10 PPM | 9| 9| 9| 0| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 1| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 2| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 1 |
Glands, Inflammation | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 2 2 3 2 4 2 3 2 2 2 2 2 2 2 2 2 2 2 4 2|
Olfactory Epithelium, Metaplasia | 2 3 3 2 3 2 4 2 1 2 2 2 3 3 3 3 3 3 2 3 3 2|
Respiratory Epithelium, Hyperplasia | 2 2 3 3 3 2 4 3 2 2 2 2 2 3 3 2 2 2 2 3 4 2|
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Degeneration | |
Lens, Cataract | 2 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Inflammation, Acute, Focal | 2 |
Nephropathy | |
Renal Tubule, Mineralization, | |
Multifocal | 2 |
__________________________________________________________________________|
Urinary Bladder | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 0| 1| 0| 7| 7| 7| 7| 5| 7| 7| 2| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 1| 1| 1| 1| 1| 4| 9| 8| 9| 4| 4| 4| 4| 4| 4| 4| 8| 4| 4| 4|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 1| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 PPM | 6| 6| 6| 6| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + |
__________________________________________________________________________|
Gallbladder | + A + |
__________________________________________________________________________|
Intestine Large | + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + M A |
__________________________________________________________________________|
Intestine Large, Colon | + M + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + |
__________________________________________________________________________|
Intestine Small | + + + A A |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A A |
Hyperplasia, Focal, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + M A |
__________________________________________________________________________|
Intestine Small, Jejunum | + M A |
__________________________________________________________________________|
Liver | + + + + |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Necrosis, Multifocal | |
__________________________________________________________________________|
Pancreas | + + + |
__________________________________________________________________________|
Salivary Glands | + + + + |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Stomach | + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + |
Mineralization, Multifocal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + |
Capsule, Hyperplasia, Multifocal | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + |
__________________________________________________________________________|
Parathyroid Gland | M M M |
__________________________________________________________________________|
Pituitary Gland | + M + |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + M + + + +|
Cyst | X X|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 0| 1| 0| 7| 7| 7| 7| 5| 7| 7| 2| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 1| 1| 1| 1| 1| 4| 9| 8| 9| 4| 4| 4| 4| 4| 4| 4| 8| 4| 4| 4|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 1| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 PPM | 6| 6| 6| 6| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst, Multifocal | X |
Hematocyst, Focal | |
__________________________________________________________________________|
Oviduct | |
Mucosa, Hyperplasia, Cystic | |
__________________________________________________________________________|
Uterus | + + + + + + M + + + + +|
Angiectasis, Multifocal | 3 |
Dilatation | |
Endometrium, Hyperplasia, Cystic | 3 3 3 4 2 4 3 2 4 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + |
__________________________________________________________________________|
Lymph Node | + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + |
__________________________________________________________________________|
Spleen | + + + + |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Thymus | + M + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + |
__________________________________________________________________________|
Skin | + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + |
Mineralization, Focal | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 3 2 2 2 |
Infiltration Cellular, Histiocyte | 2 2 |
Inflammation, Granulomatous | 3 2 2 3 2 2 2 3 2 2 2 2|
Inflammation | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 0| 1| 0| 7| 7| 7| 7| 5| 7| 7| 2| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 1| 1| 1| 1| 1| 4| 9| 8| 9| 4| 4| 4| 4| 4| 4| 4| 8| 4| 4| 4|
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 1| 3| 1| 4| 4| 4| 4| 8| 4| 4| 7| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
10 PPM | 6| 6| 6| 6| 6| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia | 1 |
Glands, Inflammation | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 4 3 3 3 2 2 3 3 3 2 3 2 2 2 3 2|
Olfactory Epithelium, Metaplasia | 3 2 3 3 3 3 2 2 2 4 3 2 3 1 1 2 3 2|
Respiratory Epithelium, Hyperplasia | 3 2 4 3 3 3 2 2 3 2 2 2 3 3 2 2 3 2|
__________________________________________________________________________|
Trachea | + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + |
Degeneration | 4 4 4 |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation, Acute, Focal | |
Nephropathy | |
Renal Tubule, Mineralization, | |
Multifocal | |
__________________________________________________________________________|
Urinary Bladder | M M + |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| |
| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
10 PPM | 6| 6| 6| 6| 6| 7| 1| 1| 1| 1| 2| 5| 5| 5| 5| 2| 2| 3| 3| 3| 5| 6| 6| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 1| 2| 3| 4| 1| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 1| 2| 1| 2| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 4 |
__________________________________________________________________________|____________|
Gallbladder | A | 2 |
__________________________________________________________________________|____________|
Intestine Large | A | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A | 3 |
__________________________________________________________________________|____________|
Intestine Small | A | 4 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A | 4 |
Hyperplasia, Focal, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | A | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + | 12 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 3 | 1 3.0|
Necrosis, Multifocal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + | 5 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 4 |
Mineralization, Multifocal | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + | 4 |
Capsule, Hyperplasia, Multifocal | | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + | 4 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 4 |
__________________________________________________________________________|____________|
Parathyroid Gland | M | |
__________________________________________________________________________|____________|
Pituitary Gland | + M | 4 |
Pars Distalis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| |
| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
10 PPM | 6| 6| 6| 6| 6| 7| 1| 1| 1| 1| 2| 5| 5| 5| 5| 2| 2| 3| 3| 3| 5| 6| 6| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 1| 2| 3| 4| 1| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 1| 2| 1| 2| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + M + + + + | 14 |
Cyst | X X X X | 9 |
Cyst, Multifocal | | 1 |
Hematocyst, Focal | | 2 |
__________________________________________________________________________|____________|
Oviduct | | 1 |
Mucosa, Hyperplasia, Cystic | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | M + + + + + + + + + + + + + + + + +| 41 |
Angiectasis, Multifocal | | 1 3.0|
Dilatation | | 2 2.5|
Endometrium, Hyperplasia, Cystic | 4 2 4 3 2 3 3 2 3 2 3 3 3 3| 36 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 4 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 6 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + | 6 |
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + | 4 |
__________________________________________________________________________|____________|
Spleen | A + + + + + + + | 13 |
Hematopoietic Cell Proliferation | 2 2 | 3 2.3|
Hyperplasia, Lymphoid | 2 2 | 3 2.3|
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 5 |
__________________________________________________________________________|____________|
Skin | + | 6 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 4 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 4 |
Mineralization, Focal | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| |
| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 7| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
10 PPM | 6| 6| 6| 6| 6| 7| 1| 1| 1| 1| 2| 5| 5| 5| 5| 2| 2| 3| 3| 3| 5| 6| 6| 8| 8| L |
| 1| 2| 3| 4| 5| 1| 1| 2| 3| 4| 1| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 1| 2| 1| 2| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + | 4 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Congestion | 3 | 1 3.0|
Hemorrhage | 1 | 1 1.0|
Infiltration Cellular, Lymphocyte | 2 2 1 2 2 2 2 3 2 2 | 21 2.1|
Infiltration Cellular, Histiocyte | 1 1 | 5 1.6|
Inflammation, Granulomatous | 2 2 2 2 2 2 2 2 2 3 2 2 | 38 2.1|
Inflammation | 3 2 2 2 3 2 | 13 2.2|
Alveolar Epithelium, Hyperplasia | 2 2 2 1 | 6 1.5|
Glands, Inflammation | | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 65 |
Inflammation | 4 3 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 65 2.3|
Olfactory Epithelium, Metaplasia | 4 3 1 2 2 1 4 3 3 2 2 3 2 3 3 2 3 3 3 3 2 3 2 3 3| 65 2.5|
Respiratory Epithelium, Hyperplasia | 3 3 2 2 3 2 3 2 3 2 2 2 2 2 3 2 2 3 2 2 2 2 2 4 2| 65 2.5|
__________________________________________________________________________|____________|
Trachea | + | 4 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 6 |
Degeneration | | 3 4.0|
Lens, Cataract | 2 | 2 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 7 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
Inflammation, Acute, Focal | | 1 2.0|
Nephropathy | 4 | 1 4.0|
Renal Tubule, Mineralization, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | M | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 1| 2|
| 3| 9| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 2| 8| 6| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | M + M + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + + + + + + + + + + + + + + + + + + A A A + A +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
__________________________________________________________________________|
Intestine Large | A + + + + + + + + + + + + + + + + + + + A A + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M + + + + + + + + + + + + + + + + + + + A M + M A|
Hyperplasia, Focal, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Large, Colon | M + + + + + + + + + + + + + + + + + + + A M + M +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | A M + + + + + + + + + + + + + + + + + + M A + + +|
__________________________________________________________________________|
Intestine Small | M + + + + + + + + + + + + + + + + + + + A M + M A|
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + + + + + + + + + + + + + + + + + A M + M A|
Hyperplasia, Focal, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + + + + + + + + + + + + A M + M A|
__________________________________________________________________________|
Intestine Small, Jejunum | M + + + + + + + + + + + + + + + + + + + A M + M A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + A + + +|
Angiectasis, Focal | |
Clear Cell Focus | X|
Focal Cellular Change, Focal | 2 |
Hematopoietic Cell Proliferation, | |
Focal | 1 |
Hematopoietic Cell Proliferation, | |
Multifocal | 1 1 |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 2 2|
Mineralization, Focal | |
Necrosis, Focal | |
Necrosis, Multifocal | 3 |
Bile Duct, Cytoplasmic Alteration, | |
Multifocal | 2 |
__________________________________________________________________________|
Mesentery | + + |
Infiltration Cellular, Multifocal, | |
Mixed Cell | |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + + + + + + + + + + + + A + A +|
Atrophy, Multifocal | 3 |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 2 1 2 1 2 |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 1| 2|
| 3| 9| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 2| 8| 6| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Multifocal | |
Vacuolization Cytoplasmic, Multifocal| 2 |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + M + + A + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Stomach | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Stomach, Glandular | M + + + + + + + + + + + + + + + + + + + + A + + M|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Adventitia, Inflammation, Multifocal | |
Media, Hypertrophy, Multifocal | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Chronic, | |
Focal | |
Myocardium, Inflammation, Focal, | |
Suppurative | |
Valve, Pigmentation, Focal | 2 2 |
Valve, Pigmentation, Multifocal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
Capsule, Hyperplasia, Multifocal | 2 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 3 3 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + A + + +|
Congestion, Multifocal | 3 2|
Degeneration, Focal | 3 |
Hypertrophy, Focal | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + A + + +|
Congestion, Multifocal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | M + M + + M + + M + + M + + + + + + M + + + + M M|
Pars Distalis, Angiectasis | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Inflammation, Acute, Focal | |
Follicle, Dilatation, Focal | |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 1| 2|
| 3| 9| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 2| 8| 6| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | M + + + + + + + + + + + + + + + + + + + + M + + +|
Cyst | 2 X X X X |
Cyst, Multifocal | |
Hematocyst, Focal | 3 |
Inflammation, Multifocal, Suppurative| |
Metaplasia, Focal, Osseous | |
__________________________________________________________________________|
Oviduct | + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + A + + +|
Angiectasis, Multifocal | |
Dilatation | 3 3 3 3 |
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 2 2 3 3 2 2 3 2 2 3 2 2 2 3 3 3 2 3 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukocytosis | 3 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Congestion | 2|
Hyperplasia | 2 |
Myelofibrosis | 2 |
Pigmentation, Focal | |
Pigmentation, Multifocal | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + + + M + + M + M + M + M M + +|
Congestion | 2 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M + M + + +|
Erythrophagocytosis | |
Hemorrhage | |
Pigmentation | 2 2 2 2 2 2 2|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + M + M + + + M + + M + M +|
Erythrophagocytosis | 3 |
Hyperplasia, Lymphoid | |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + M + M M|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 1| 2|
| 3| 9| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 2| 8| 6| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Erythrophagocytosis | |
Giant Cell, Multifocal | 2 2 1 2 2 |
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + A + + +|
Angiectasis, Multifocal | |
Congestion | 3 |
Hematopoietic Cell Proliferation | 2 3 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + M + + + M + + +|
Depletion Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Duct, Galactocele, Multifocal | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy, Focal | |
Fibrous Osteodystrophy, Multifocal | 2 2 2 2 2 2 |
Hyperplasia, Multifocal | |
Metaplasia, Cartilagenous, Focal | |
__________________________________________________________________________|
Skeletal Muscle | |
Head, Hemorrhage, Multifocal | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Multifocal | |
Hemorrhage, Multifocal | |
Mineralization, Focal | 2 1 1 1 1 |
Mineralization, Multifocal | 2 2 2 |
Cerebrum, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 2 2 3 2 2|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 1| 2|
| 3| 9| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 2| 8| 6| 9| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | 2 2 |
Inflammation, Granulomatous | 3 2 |
Inflammation | 1 2 3 1 2 3 1 2 2 2 2 2 2 2 |
Metaplasia, Focal, Osseous | |
Alveolar Epithelium, Hyperplasia | 1 1 1|
Glands, Inflammation | 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation | 3 2 3 2 2 2 3 2 2 2 3 2 2 2 2 2 3 2 2 2 3 2 3 2 2|
Olfactory Epithelium, Metaplasia | 2 3 4 2 3 2 3 4 3 3 4 3 4 3 2 2 3 3 3 2 3 1 3 2 2|
Respiratory Epithelium, Hyperplasia | 3 3 4 2 2 3 3 2 2 2 3 3 3 3 3 3 3 3 3 3 3 2 3 3 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Degeneration | |
Mineralization | |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + A + + +|
Fibrosis, Focal | |
Hemorrhage, Multifocal | |
Infarct, Focal | |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 1 2|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 2 2 2 2 2 3 2 1 2 1 2 |
Nephropathy | |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + M + + +|
Dilatation | |
Infiltration Cellular, Focal, | |
Lymphocyte | 1|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 3 3 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 4| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 5| 3| 1| 4| 4| 6| 4| 4| 4| 4| 6|
| 9| 9| 9| 9| 9| 9| 6| 9| 1| 9| 9| 9| 9| 4| 1| 9| 4| 2| 2| 6| 2| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + M + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 1 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia, Focal, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Clear Cell Focus | |
Focal Cellular Change, Focal | |
Hematopoietic Cell Proliferation, | |
Focal | 1 |
Hematopoietic Cell Proliferation, | |
Multifocal | 1 1 2 1 |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 2 2 1 2 |
Mineralization, Focal | |
Necrosis, Focal | 1 |
Necrosis, Multifocal | |
Bile Duct, Cytoplasmic Alteration, | |
Multifocal | |
__________________________________________________________________________|
Mesentery | |
Infiltration Cellular, Multifocal, | |
Mixed Cell | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Multifocal | |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 1 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 4| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 5| 3| 1| 4| 4| 6| 4| 4| 4| 4| 6|
| 9| 9| 9| 9| 9| 9| 6| 9| 1| 9| 9| 9| 9| 4| 1| 9| 4| 2| 2| 6| 2| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Multifocal | |
Vacuolization Cytoplasmic, Multifocal| |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + M|
Infiltration Cellular, Focal, | |
Lymphocyte | 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 1 2 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Adventitia, Inflammation, Multifocal | 3 |
Media, Hypertrophy, Multifocal | 4 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Chronic, | |
Focal | 2 |
Myocardium, Inflammation, Focal, | |
Suppurative | 2 |
Valve, Pigmentation, Focal | 1 1 2 1 |
Valve, Pigmentation, Multifocal | 1 1 1 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia, Multifocal | 2 3 3 3 3 3 2 3 3 2 3 2 3 3 2 3 2 2 2 3 3 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Multifocal | 2 |
Degeneration, Focal | |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + M + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Multifocal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + M + M + + M + + M + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Inflammation, Acute, Focal | 1 |
Follicle, Dilatation, Focal | 3 |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 4| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 5| 3| 1| 4| 4| 6| 4| 4| 4| 4| 6|
| 9| 9| 9| 9| 9| 9| 6| 9| 1| 9| 9| 9| 9| 4| 1| 9| 4| 2| 2| 6| 2| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hyperplasia, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X 3 X X X X |
Cyst, Multifocal | |
Hematocyst, Focal | 2 |
Inflammation, Multifocal, Suppurative| 2 |
Metaplasia, Focal, Osseous | 2 |
__________________________________________________________________________|
Oviduct | + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | 3 |
Dilatation | 3 3 |
Inflammation, Suppurative | 2 |
Endometrium, Hyperplasia, Cystic | 1 4 1 2 4 4 3 3 2 3 2 3 2 2 3 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Atrophy | 2 2 2 |
Congestion | |
Hyperplasia | |
Myelofibrosis | 2 3 |
Pigmentation, Focal | 2 |
Pigmentation, Multifocal | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + M M M + + + + M + + + + M + + + + + + + + + M|
Congestion | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M|
Erythrophagocytosis | |
Hemorrhage | 2 |
Pigmentation | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + + M M + + + + M + + + + M + + M|
Erythrophagocytosis | |
Hyperplasia, Lymphoid | |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 4| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 5| 3| 1| 4| 4| 6| 4| 4| 4| 4| 6|
| 9| 9| 9| 9| 9| 9| 6| 9| 1| 9| 9| 9| 9| 4| 1| 9| 4| 2| 2| 6| 2| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Erythrophagocytosis | |
Giant Cell, Multifocal | 2 2 2 2 1 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Multifocal | 3 |
Congestion | |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Duct, Galactocele, Multifocal | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy, Focal | 3 |
Fibrous Osteodystrophy, Multifocal | 2 2 |
Hyperplasia, Multifocal | |
Metaplasia, Cartilagenous, Focal | |
__________________________________________________________________________|
Skeletal Muscle | +|
Head, Hemorrhage, Multifocal | 3|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Multifocal | 3 |
Hemorrhage, Multifocal | 2 |
Mineralization, Focal | 1 2 2 1 1 |
Mineralization, Multifocal | 1 1 1 |
Cerebrum, Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + M + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 4| 7| 7| 7| 7| 0|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 5| 3| 1| 4| 4| 6| 4| 4| 4| 4| 6|
| 9| 9| 9| 9| 9| 9| 6| 9| 1| 9| 9| 9| 9| 4| 1| 9| 4| 2| 2| 6| 2| 2| 2| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Histiocyte | |
Inflammation, Granulomatous | 2 3 3 3 3 2 |
Inflammation | 3 2 2 2 2 2 2 2 2 2 2 3 3 |
Metaplasia, Focal, Osseous | 1 |
Alveolar Epithelium, Hyperplasia | 1 1 |
Glands, Inflammation | 2 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation | 3 2 3 3 3 2 2 3 2 2 2 2 3 2 2 3 3 3 2 2 2 2 2 2|
Olfactory Epithelium, Metaplasia | 2 2 2 2 3 4 2 3 2 2 3 2 4 3 3 4 3 4 4 3 3 3 3 1|
Respiratory Epithelium, Hyperplasia | 4 3 4 4 3 3 2 3 4 2 4 3 4 2 3 4 3 3 2 2 3 3 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Degeneration | |
Mineralization | |
Lens, Cataract | 3 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 1 |
Hemorrhage, Multifocal | 2 |
Infarct, Focal | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 1 2 1 2 2 2 2 2 1 2 2 2 |
Nephropathy | 2 2 |
__________________________________________________________________________|
Urinary Bladder | M + + + + + + + + + + + M + + + + + + + + + + +|
Dilatation | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 1 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 1 1 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 0| 7| 4| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 9| 4| 2| 4| 8| 4| 4| 7| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 4| 4| 4| 4| 4| 2| 1| 2| 7| 2| 8| 2| 2| 7| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Gallbladder | + + M + A + + + + + + + + + + + + + +| 60 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 2 1.5|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + M + + + + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + M + A + + + + + + + + + + + + + +| 60 |
Hyperplasia, Focal, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + M + + + + + + + + + + + + + + + +| 62 |
Parasite Metazoan | X X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + +| 63 |
__________________________________________________________________________|____________|
Intestine Small | + + M + + + + + + + + + + + + + + + +| 61 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + M + + + + + + + + + + + + + + + +| 61 |
Hyperplasia, Focal, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + M + + + + + + + + + + + + + + + +| 61 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + M + + + + + + + + + + + + + + + +| 61 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + +| 67 |
Angiectasis, Focal | | 1 2.0|
Clear Cell Focus | | 1 |
Focal Cellular Change, Focal | | 1 2.0|
Hematopoietic Cell Proliferation, | | |
Focal | | 2 1.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 1 | 7 1.1|
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 2| 5 1.4|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 1 2 2 2 2 | 16 1.8|
Mineralization, Focal | 1 | 1 1.0|
Necrosis, Focal | | 1 1.0|
Necrosis, Multifocal | 3 | 2 3.0|
Bile Duct, Cytoplasmic Alteration, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Infiltration Cellular, Multifocal, | | |
Mixed Cell | 2 | 1 2.0|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 0| 7| 4| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 9| 4| 2| 4| 8| 4| 4| 7| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 4| 4| 4| 4| 4| 2| 1| 2| 7| 2| 8| 2| 2| 7| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Atrophy, Multifocal | | 1 3.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 | 3 1.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 1 2 2| 17 1.6|
Inflammation, Multifocal | 2 | 1 2.0|
Vacuolization Cytoplasmic, Multifocal| | 1 2.0|
Duct, Dilatation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + M + + + + + + + + + + + + + + + +| 64 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 1 | 3 1.3|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 2 2 2 1 2 3 2| 34 1.9|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +| 67 |
Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +| 65 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Adventitia, Inflammation, Multifocal | | 1 3.0|
Media, Hypertrophy, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + +| 68 |
Myocardium, Inflammation, Chronic, | | |
Focal | | 1 2.0|
Myocardium, Inflammation, Focal, | | |
Suppurative | | 1 2.0|
Valve, Pigmentation, Focal | | 6 1.5|
Valve, Pigmentation, Multifocal | 2 1 | 7 1.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +| 67 |
Capsule, Hyperplasia, Multifocal | 3 3 3 3 2 3 3 3 3 2 3 3 3 3 3 2 2 2 2| 67 2.7|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +| 67 |
Congestion, Multifocal | | 3 2.3|
Degeneration, Focal | | 1 3.0|
Hypertrophy, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + +| 66 |
Congestion, Multifocal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 0| 7| 4| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 9| 4| 2| 4| 8| 4| 4| 7| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 4| 4| 4| 4| 4| 2| 1| 2| 7| 2| 8| 2| 2| 7| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M M + + + + + + + M + + + + M M +| 50 |
Pars Distalis, Angiectasis | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +| 67 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Inflammation, Acute, Focal | 2 | 2 1.5|
Follicle, Dilatation, Focal | 2 | 2 2.5|
Follicular Cell, Hyperplasia, Focal | 2 3 | 2 2.5|
Follicular Cell, Hyperplasia, | | |
Multifocal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + +| 66 |
Cyst | 2 2 2 2| 16 2.2|
Cyst, Multifocal | 3 | 1 3.0|
Hematocyst, Focal | | 2 2.5|
Inflammation, Multifocal, Suppurative| | 1 2.0|
Metaplasia, Focal, Osseous | | 1 2.0|
__________________________________________________________________________|____________|
Oviduct | | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + +| 67 |
Angiectasis, Multifocal | | 1 3.0|
Dilatation | 2 | 7 2.9|
Inflammation, Suppurative | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 4 3 2 3 3 2 2 3 2 3 2 2 3| 49 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Leukocytosis | | 1 3.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +| 68 |
Angiectasis | | 1 2.0|
Atrophy | 2 | 4 2.0|
Congestion | | 1 2.0|
Hyperplasia | | 1 2.0|
Myelofibrosis | | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 0| 7| 4| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 9| 4| 2| 4| 8| 4| 4| 7| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 4| 4| 4| 4| 4| 2| 1| 2| 7| 2| 8| 2| 2| 7| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pigmentation, Focal | | 1 2.0|
Pigmentation, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M + M + + + + + + M M M M + M + M| 46 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M + + + + + M + + + + + + + + + +| 62 |
Erythrophagocytosis | 2 | 1 2.0|
Hemorrhage | | 1 2.0|
Pigmentation | 2 2 | 12 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + M + + + + + M M + + + + + + +| 52 |
Erythrophagocytosis | | 1 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Pigmentation | 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + M + M + + M + + + + + +| 60 |
Erythrophagocytosis | 2 | 1 2.0|
Giant Cell, Multifocal | 1 2 2 2 2 | 16 1.8|
Hemorrhage | | 2 2.0|
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + +| 67 |
Angiectasis, Multifocal | | 1 3.0|
Congestion | | 1 3.0|
Hematopoietic Cell Proliferation | 3 3 | 7 2.6|
Hyperplasia, Lymphoid | 3 2 2 3 | 6 2.5|
__________________________________________________________________________|____________|
Thymus | + + M + M + + + + M + + M + M + + + +| 60 |
Depletion Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + + + + + + + + + +| 66 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
Duct, Galactocele, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + M + + + + + + + + + + + + + + + +| 67 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + +| 68 |
Fibrous Osteodystrophy, Focal | 2 2 2 | 4 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 0| 7| 4| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 9| 4| 2| 4| 8| 4| 4| 7| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 4| 4| 4| 4| 4| 2| 1| 2| 7| 2| 8| 2| 2| 7| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Fibrous Osteodystrophy, Multifocal | 2 2 2 2 | 12 2.0|
Hyperplasia, Multifocal | 2 | 1 2.0|
Metaplasia, Cartilagenous, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 3 |
Head, Hemorrhage, Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + +| 68 |
Fibrosis, Multifocal | | 1 3.0|
Hemorrhage, Multifocal | | 1 2.0|
Mineralization, Focal | 1 | 11 1.3|
Mineralization, Multifocal | 1 2 | 8 1.5|
Cerebrum, Necrosis, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + M + + + + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + +| 68 |
Congestion | 3 | 1 3.0|
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | 2 2 2 3 2 2 2 3 2 2 2| 20 2.2|
Infiltration Cellular, Histiocyte | | 2 2.0|
Inflammation, Granulomatous | 3 2 2 3 2 2 | 14 2.5|
Inflammation | 3 3 2 2 1 2 3 | 35 2.1|
Metaplasia, Focal, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 5 1.0|
Glands, Inflammation | 2 | 7 1.9|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + +| 68 |
Hemorrhage | 2 | 2 2.5|
Inflammation | 3 3 3 3 2 4 2 2 4 2 3 2 3 2 3 2 2 2 2| 68 2.4|
Olfactory Epithelium, Metaplasia | 2 3 2 3 3 2 4 3 3 3 2 2 3 2 3 2 3 3 1| 68 2.7|
Respiratory Epithelium, Hyperplasia | 2 3 2 4 2 3 3 3 2 3 2 3 3 2 3 2 2 3 2| 68 2.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + +| 68 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Degeneration | 4 | 1 4.0|
Mineralization | 4 | 1 4.0|
Lens, Cataract | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 0| 7| 4| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 9| 4| 2| 4| 8| 4| 4| 7| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 4| 4| 4| 4| 4| 2| 1| 2| 7| 2| 8| 2| 2| 7| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + +| 67 |
Fibrosis, Focal | | 1 1.0|
Hemorrhage, Multifocal | | 1 2.0|
Infarct, Focal | | 1 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 1 | 7 1.7|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 3 2 2 2 2 3 2 2 2 2 2| 40 2.0|
Nephropathy | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + M + + + + + + + M + + + + + + +| 62 |
Dilatation | | 1 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 2 | 6 1.7|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 2 2 2 2 2 2 2 2 | 42 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 4| 5| 2| 7| 4| 4| 5| 4| 2| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 3| 4| 4|
| 3| 8| 3| 8| 3| 1| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + + + + + + + + + + + + + M A + +|
Dilatation | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + A + +|
Hyperplasia, Focal, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A A + + + + + + + + + + + + + + + + + +|
Amyloid Deposition, Multifocal | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 3 |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 2 2 |
Mineralization, Focal | |
Necrosis, Focal | 2 |
Necrosis, Multifocal | 3 |
Pigmentation, Focal | 2 |
Hepatocyte, Atrophy, Diffuse | |
__________________________________________________________________________|
Mesentery | + |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 |
Atrophy, Multifocal | 3 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 2 2 2|
Inflammation, Multifocal | 2 |
Acinus, Hyperplasia, Focal | |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 4| 5| 2| 7| 4| 4| 5| 4| 2| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 3| 4| 4|
| 3| 8| 3| 8| 3| 1| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Lymphocyte | 2 2 2 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Focal | 2|
Hyperplasia, Focal | 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 |
Mucosa, Cyst | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Valve, Pigmentation, Focal | |
Valve, Pigmentation, Multifocal | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia, Multifocal | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 2 3 3 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Focal | 2 |
Degeneration, Focal | |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + M M + + + M + + + + M + + + + + M M + + +|
Cyst, Multifocal | |
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 2|
Inflammation, Acute, Focal | 2 |
Follicle, Dilatation, Focal | 2|
Follicular Cell, Hyperplasia, Focal | 1|
Follicular Cell, Hyperplasia, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 4| 5| 2| 7| 4| 4| 5| 4| 2| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 3| 4| 4|
| 3| 8| 3| 8| 3| 1| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hypertrophy, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
__________________________________________________________________________|
Ovary | + + + M + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X 2|
Cyst, Multifocal | |
Giant Cell, Multiple | 2 |
Hematocyst, Focal | |
Infiltration Cellular, Histiocyte | 3 |
Mineralization, Multifocal | |
Follicle, Hemorrhage, Focal | 3 |
__________________________________________________________________________|
Oviduct | + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 4 |
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 3 2 4 2 3 2 4 4 3 3 3 3 3 3 4 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Leukocytosis | 3 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy, Focal | |
Hyperplasia | 3 |
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M M M M + M + + M M + + M M M + M + + +|
Hyperplasia, Lymphoid | 3|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 3 3 |
Infiltration Cellular, Histiocyte | |
Pigmentation | 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M M + + + + + + + + + + + M + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + +|
Erythrophagocytosis | |
Giant Cell, Multifocal | 2|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 4| 5| 2| 7| 4| 4| 5| 4| 2| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 3| 4| 4|
| 3| 8| 3| 8| 3| 1| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | |
Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 3 3 |
Hyperplasia, Lymphoid | 3 2 3 3 |
Hyperplasia, Neutrophil | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + M M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Multifocal | 3 |
Inflammation, Focal | 2 |
Subcutaneous Tissue, Infiltration | |
Cellular, Multifocal, | |
Polymorphonuclear | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy, Focal | 2 |
Fibrous Osteodystrophy, Multifocal | 2 2 2 3 |
__________________________________________________________________________|
Skeletal Muscle | + |
Hindlimb, Infiltration Cellular, | |
Focal, Lymphocyte | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal | 3 2 |
Mineralization, Focal | 2 |
Mineralization, Multifocal | 2 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 3 2 2 3 1 2 2|
Infiltration Cellular, Histiocyte | |
Inflammation, Granulomatous | 2 2 2 2 2 2 2 2 2 3|
Inflammation | 2 2 2 2 2 |
Alveolar Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 4| 7| 7| 1| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 0| 4| 5| 2| 7| 4| 4| 5| 4| 2| 4| 4| 4| 2| 4| 4| 6| 4| 4| 4| 4| 3| 4| 4|
| 3| 8| 3| 8| 3| 1| 3| 3| 6| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Glands, Inflammation | 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation | 2 2 2 2 3 2 2 3 2 3 2 2 2 2 3 3 2 2 2 2 3 2 3 3|
Olfactory Epithelium, Metaplasia | 3 2 1 1 2 3 1 2 1 2 2 2 2 2 1 3 2 3 2 2 3 2 2 2|
Respiratory Epithelium, Hyperplasia | 3 3 2 3 2 3 3 3 2 3 3 3 2 2 3 3 2 3 2 2 3 2 3 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Dilatation, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Inflammation | |
Pigmentation | |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2|
Nephropathy | 2 2 2 |
Glomerulus, Amyloid Deposition, | |
Multifocal | |
Renal Tubule, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + + +|
Dilatation | |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 2 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 3 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 9|
| 3| 3| 3| 3| 3| 7| 5| 3| 3| 3| 3| 0| 3| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia, Focal, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + M|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + M|
Amyloid Deposition, Multifocal | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Hematopoietic Cell Proliferation, | |
Multifocal | 1 1 |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 3 2 3 2 2 2|
Mineralization, Focal | 2 |
Necrosis, Focal | |
Necrosis, Multifocal | |
Pigmentation, Focal | |
Hepatocyte, Atrophy, Diffuse | |
__________________________________________________________________________|
Mesentery | + |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Atrophy, Multifocal | |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 1 2 2 2 2 2 1 |
Inflammation, Multifocal | |
Acinus, Hyperplasia, Focal | 1 |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 9|
| 3| 3| 3| 3| 3| 7| 5| 3| 3| 3| 3| 0| 3| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Lymphocyte | 1 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 2 2 3 2 2 3 2 2 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Focal | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Mucosa, Cyst | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Valve, Pigmentation, Focal | 1 1 2 |
Valve, Pigmentation, Multifocal | 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia, Multifocal | 3 3 2 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 2 3 3 2 2 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M M + + + + + + + + + + + + + + +|
Cyst, Focal | |
Degeneration, Focal | |
Infiltration Cellular, Focal, | |
Lymphocyte | 3 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Bilateral, Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + M + + + + + + + + M|
Cyst, Multifocal | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Inflammation, Acute, Focal | 1 |
Follicle, Dilatation, Focal | 2 3 2 |
Follicular Cell, Hyperplasia, Focal | 2 |
Follicular Cell, Hyperplasia, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 9|
| 3| 3| 3| 3| 3| 7| 5| 3| 3| 3| 3| 0| 3| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Hypertrophy, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + M|
Cyst | 2 2 2 |
Cyst, Multifocal | 2 |
Giant Cell, Multiple | |
Hematocyst, Focal | |
Infiltration Cellular, Histiocyte | |
Mineralization, Multifocal | 2 |
Follicle, Hemorrhage, Focal | |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + M|
Dilatation | 4 |
Inflammation, Suppurative | |
Endometrium, Hyperplasia, Cystic | 2 3 4 4 3 3 3 2 3 3 3 3 3 2 3 3 4 3 4 4 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukocytosis | 2 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy, Focal | |
Hyperplasia | |
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Bronchial | M M + M + M + + + M + M M + M M M + M + + + M +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Histiocyte | |
Pigmentation | 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + M M + + + + + + + M + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + M + + + + + + M|
Erythrophagocytosis | |
Giant Cell, Multifocal | 2 2 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 9|
| 3| 3| 3| 3| 3| 7| 5| 3| 3| 3| 3| 0| 3| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | 2 3 2 2 |
Hyperplasia, Neutrophil | |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Multifocal | |
Inflammation, Focal | |
Subcutaneous Tissue, Infiltration | |
Cellular, Multifocal, | |
Polymorphonuclear | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy, Focal | 2 1 2 |
Fibrous Osteodystrophy, Multifocal | 2 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
Hindlimb, Infiltration Cellular, | |
Focal, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal | |
Mineralization, Focal | 1|
Mineralization, Multifocal | 1 2 1 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + M + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 2 2 1 2 2 2 3 |
Infiltration Cellular, Histiocyte | |
Inflammation, Granulomatous | 2 2 2 2 2 2 2 2 2 3 |
Inflammation | 2 2 2 3 2 2 2 2|
Alveolar Epithelium, Hyperplasia | 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 2| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 4| 4| 4| 4| 2| 1| 4| 4| 4| 4| 6| 4| 5| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 9|
| 3| 3| 3| 3| 3| 7| 5| 3| 3| 3| 3| 0| 3| 9| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Glands, Inflammation | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation | 3 2 3 3 2 1 2 2 3 2 2 2 3 3 2 2 2 3 2 3 4 2 2 2|
Olfactory Epithelium, Metaplasia | 3 4 2 3 1 2 2 3 3 2 2 2 4 2 2 2 2 3 2 3 3 3 2 2|
Respiratory Epithelium, Hyperplasia | 3 3 3 3 2 2 3 3 3 2 2 3 3 2 2 2 2 3 2 3 3 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Dilatation, Multifocal | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Inflammation | |
Pigmentation | |
Lens, Cataract | |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 3 1 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2|
Nephropathy | |
Glomerulus, Amyloid Deposition, | |
Multifocal | 2 |
Renal Tubule, Hyperplasia, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + M|
Dilatation | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 3 2 2 2 2 3 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 1| 2| |
| 4| 4| 4| 4| 4| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + +| 64 |
Dilatation | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +| 64 |
Hyperplasia, Focal, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +| 66 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + +| 63 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +| 63 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +| 63 |
Amyloid Deposition, Multifocal | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +| 63 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + +| 67 |
Angiectasis, Focal | | 1 3.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 1 3 1 | 5 1.4|
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 2 1 | 7 1.9|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 3 1 2 1 1 2 | 17 1.9|
Mineralization, Focal | | 1 2.0|
Necrosis, Focal | 3 | 2 2.5|
Necrosis, Multifocal | | 1 3.0|
Pigmentation, Focal | | 1 2.0|
Hepatocyte, Atrophy, Diffuse | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + +| 67 |
Atrophy, Focal | | 1 1.0|
Atrophy, Multifocal | | 1 3.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 | 17 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 1| 2| |
| 4| 4| 4| 4| 4| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation, Multifocal | | 1 2.0|
Acinus, Hyperplasia, Focal | | 1 1.0|
Duct, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +| 67 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 2 1 2 | 10 1.6|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 2 2 3 3 2 1 2 1 | 30 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + +| 67 |
Hyperkeratosis, Focal | | 1 2.0|
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + +| 67 |
Hemorrhage, Focal | | 1 2.0|
Mucosa, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + +| 67 |
Valve, Pigmentation, Focal | 2 1 1 | 6 1.3|
Valve, Pigmentation, Multifocal | 1 | 7 1.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + +| 67 |
Capsule, Hyperplasia, Multifocal | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 2| 66 2.9|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + +| 67 |
Focal Cellular Change | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + +| 66 |
Degeneration | | 1 3.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + +| 64 |
Cyst, Focal | | 1 2.0|
Degeneration, Focal | 2 | 1 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 3.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
Bilateral, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + M + + + + M + + + + + M + + + M| 54 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 1| 2| |
| 4| 4| 4| 4| 4| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Cyst, Multifocal | 2 | 1 2.0|
Pars Distalis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + +| 66 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 2 2.0|
Inflammation, Acute, Focal | | 2 1.5|
Follicle, Dilatation, Focal | 2 | 5 2.2|
Follicular Cell, Hyperplasia, Focal | 2 2 | 4 1.8|
Follicular Cell, Hyperplasia, | | |
Multifocal | | 1 2.0|
Follicular Cell, Hypertrophy, | | |
Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + +| 65 |
Cyst | 2 2 2 3 | 11 2.1|
Cyst, Multifocal | 4 | 2 3.0|
Giant Cell, Multiple | | 1 2.0|
Hematocyst, Focal | 4 2 | 2 3.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Mineralization, Multifocal | | 1 2.0|
Follicle, Hemorrhage, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Oviduct | | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + +| 66 |
Dilatation | 3 4 | 6 3.5|
Inflammation, Suppurative | 3 | 1 3.0|
Endometrium, Hyperplasia, Cystic | 3 3 4 4 2 2 2 3 4 4 4 2 2 2 3 3 2 | 56 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + +| 5 |
Leukocytosis | 4 | 3 3.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +| 67 |
Fibrous Osteodystrophy, Focal | 2 | 1 2.0|
Hyperplasia | | 1 3.0|
Hyperplasia, Neutrophil | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 1| 2| |
| 4| 4| 4| 4| 4| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + +| 67 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + + + + + M + + M + + M| 40 |
Hyperplasia, Lymphoid | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + M + + + +| 65 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 4 | 4 3.3|
Infiltration Cellular, Histiocyte | 3 | 1 3.0|
Pigmentation | 2 3 2 2 2 3| 13 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + + + M + + + M + M + + + +| 57 |
Hyperplasia, Lymphoid | | 2 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M| 62 |
Erythrophagocytosis | 2 | 1 2.0|
Giant Cell, Multifocal | 2 2 | 8 1.8|
Hemorrhage | 2 | 2 2.0|
Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + +| 67 |
Hematopoietic Cell Proliferation | 3 2 3 3| 10 2.8|
Hyperplasia, Lymphoid | 3 2 3 2 | 12 2.5|
Hyperplasia, Neutrophil | 4 | 1 4.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + + + M M| 59 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + +| 66 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 2 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + +| 67 |
Acanthosis, Multifocal | | 1 3.0|
Inflammation, Focal | | 1 2.0|
Subcutaneous Tissue, Infiltration | | |
Cellular, Multifocal, | | |
Polymorphonuclear | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 1| 2| |
| 4| 4| 4| 4| 4| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Fibrous Osteodystrophy, Focal | 2 2 | 6 1.8|
Fibrous Osteodystrophy, Multifocal | 2 2 2 3 2 | 11 2.2|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
Hindlimb, Infiltration Cellular, | | |
Focal, Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + +| 67 |
Hemorrhage, Multifocal | | 2 2.5|
Mineralization, Focal | 2 | 3 1.7|
Mineralization, Multifocal | 2 2 2 1 1 1 1 2 1 1| 21 1.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + M + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + +| 67 |
Infiltration Cellular, Lymphocyte | 2 3 2 3 2 2 2 | 26 2.1|
Infiltration Cellular, Histiocyte | 2 2 | 2 2.0|
Inflammation, Granulomatous | 2 3 2 2 2 2 2 2 | 28 2.1|
Inflammation | 2 2 2 1 2 | 18 2.0|
Alveolar Epithelium, Hyperplasia | 2 2 1 | 7 1.4|
Glands, Inflammation | 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + +| 67 |
Hemorrhage | | 1 2.0|
Inflammation | 2 3 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2| 67 2.3|
Olfactory Epithelium, Metaplasia | 2 2 3 3 2 1 1 2 2 2 2 2 1 2 2 1 2 2 2| 67 2.1|
Respiratory Epithelium, Hyperplasia | 3 3 3 4 3 3 2 3 3 3 2 3 3 2 3 2 2 2 2| 67 2.6|
__________________________________________________________________________|____________|
Trachea | + + + + + M + + + + + + + + + + + + +| 66 |
Glands, Dilatation, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 4 |
Inflammation | 4 | 1 4.0|
Pigmentation | 3 | 1 3.0|
Lens, Cataract | 3 3 | 2 3.0|
Retina, Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| 4| 1| 2| |
| 4| 4| 4| 4| 4| 8| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| A |
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 1 2 2 2 2 2 2 2 2 2 | 42 2.0|
Nephropathy | 2 | 4 2.0|
Glomerulus, Amyloid Deposition, | | |
Multifocal | | 1 2.0|
Renal Tubule, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + M + + + + + + + + + M +| 63 |
Dilatation | | 1 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 3 2 | 5 2.2|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 1 2 2 2 2 2 1 3 2 | 37 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 6| 3| 5| 7| 7| 2| 7| 3| 7| 6| 7| 3| 7| 7| 7| 6| 3| 6| 7| 1| 7| 7| 7| 1| 7|
DAY ON TEST | 5| 9| 5| 3| 0| 8| 3| 8| 3| 9| 1| 8| 3| 3| 3| 8| 8| 2| 0| 3| 3| 3| 0| 8| 3|
| 2| 6| 8| 6| 6| 2| 6| 3| 6| 7| 4| 9| 6| 6| 6| 8| 2| 0| 0| 4| 6| 6| 6| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + A + A + + A + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + M + + + + + + + + + + + + + + + + +|
Inflammation, Diffuse | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Inflammation, Diffuse | 4 |
__________________________________________________________________________|
Intestine Small | + + + + A + + A + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A A + A + + M + A + + + + + + A + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + A + A + + A + A + + + + + + A + + + + + A + +|
Inflammation, Multifocal | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + A + + + + + + + + A + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Fatty Change, Focal | 2 2 |
Hematopoietic Cell Proliferation, | |
Focal | 1 |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Necrosis, Multifocal | 3 |
Sinusoid, Ectasia, Focal | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 1|
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 1 2 2 1 2|
Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Stomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 6| 3| 5| 7| 7| 2| 7| 3| 7| 6| 7| 3| 7| 7| 7| 6| 3| 6| 7| 1| 7| 7| 7| 1| 7|
DAY ON TEST | 5| 9| 5| 3| 0| 8| 3| 8| 3| 9| 1| 8| 3| 3| 3| 8| 8| 2| 0| 3| 3| 3| 0| 8| 3|
| 2| 6| 8| 6| 6| 2| 6| 3| 6| 7| 4| 9| 6| 6| 6| 8| 2| 0| 0| 4| 6| 6| 6| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + A + + + + + + + +|
Infiltration Cellular, | |
Polymorphonuclear | |
Inflammation, Acute, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, | |
Polymorphonuclear | |
Myocardium, Inflammation, Multifocal | 2 |
Valve, Pigmentation, Focal | 1 2 2 1 |
Valve, Pigmentation, Multifocal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia, Multifocal | 2 2 2 2 1 2 2 2 3 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | M + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Clear Cell Focus | X |
Focal Cellular Change | 2 |
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Parathyroid Gland | M + M + A + + + + + + + + + + + + + + + + + + + +|
Cyst, Focal | |
__________________________________________________________________________|
Pituitary Gland | M + M + + + M M + + + M + M + + + M + + + + + + +|
Pars Distalis, Congestion | 2 |
__________________________________________________________________________|
Thyroid Gland | M + + + A + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, | |
Polymorphonuclear | |
Spermatocele, Focal | |
__________________________________________________________________________|
Penis | + |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 6| 3| 5| 7| 7| 2| 7| 3| 7| 6| 7| 3| 7| 7| 7| 6| 3| 6| 7| 1| 7| 7| 7| 1| 7|
DAY ON TEST | 5| 9| 5| 3| 0| 8| 3| 8| 3| 9| 1| 8| 3| 3| 3| 8| 8| 2| 0| 3| 3| 3| 0| 8| 3|
| 2| 6| 8| 6| 6| 2| 6| 3| 6| 7| 4| 9| 6| 6| 6| 8| 2| 0| 0| 4| 6| 6| 6| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Multifocal | |
__________________________________________________________________________|
Preputial Gland | M + |
Inflammation | |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Prostate | + + + + A + + + + + + + + + + + + + + + M + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Infiltration Cellular, | |
Polymorphonuclear | |
Inflammation, Acute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + M + + M + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Focal | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 1 1 |
Bilateral, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
Leukocytosis | X X |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 2 3 |
Thrombosis | |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + M + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M + + + + + + M + M M M + + M + + M M +|
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, | |
Polymorphonuclear | |
Pigmentation | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + M + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | 2 |
Infiltration Cellular, | |
Polymorphonuclear | |
Pigmentation | 2 2 2 2 2 2 |
Lymphocyte, Necrosis, Multifocal | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M + M M + + M + + M + + M + + M + + M + +|
Infiltration Cellular, | |
Polymorphonuclear | |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + A M + M + + + + + + + + + + + + + + + + +|
Angiectasis | |
Erythrophagocytosis | 2 |
Giant Cell, Multifocal | 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 6| 3| 5| 7| 7| 2| 7| 3| 7| 6| 7| 3| 7| 7| 7| 6| 3| 6| 7| 1| 7| 7| 7| 1| 7|
DAY ON TEST | 5| 9| 5| 3| 0| 8| 3| 8| 3| 9| 1| 8| 3| 3| 3| 8| 8| 2| 0| 3| 3| 3| 0| 8| 3|
| 2| 6| 8| 6| 6| 2| 6| 3| 6| 7| 4| 9| 6| 6| 6| 8| 2| 0| 0| 4| 6| 6| 6| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | |
Granulocytic | 4 |
Hemorrhage | 4 1 2|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Infiltration Cellular, | |
Polymorphonuclear | |
Inflammation, Acute | 2 2 2 |
Lymphocyte, Necrosis, Multifocal | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hematopoietic Cell Proliferation | 3 4 3 4 3 3 4 2 |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Hyperplasia, Lymphoid | 2 |
Lymphocyte, Necrosis | |
__________________________________________________________________________|
Thymus | + M M + M + + M M M M + + + + M + + M M + + M + +|
Cyst | X |
Depletion Lymphoid, Diffuse | 4 |
Hyperplasia, Lymphoid, Multifocal | 2 |
Thymocyte, Necrosis | 4 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M + M M M M M M + M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | 2 2 |
Cyst Epithelial Inclusion | X |
Infiltration Cellular, | |
Polymorphonuclear | |
Inflammation, Focal | 2 |
Ulcer | 3 |
Prepuce, Inflammation, Chronic Active| |
Prepuce, Ulcer | |
Subcutaneous Tissue, Edema, Diffuse | |
Subcutaneous Tissue, Fibrosis, | |
Multifocal | 2 |
Subcutaneous Tissue, Hemorrhage | |
Tail, Inflammation, Multifocal, | |
Necrotizing | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Developmental Malformation | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 6| 3| 5| 7| 7| 2| 7| 3| 7| 6| 7| 3| 7| 7| 7| 6| 3| 6| 7| 1| 7| 7| 7| 1| 7|
DAY ON TEST | 5| 9| 5| 3| 0| 8| 3| 8| 3| 9| 1| 8| 3| 3| 3| 8| 8| 2| 0| 3| 3| 3| 0| 8| 3|
| 2| 6| 8| 6| 6| 2| 6| 3| 6| 7| 4| 9| 6| 6| 6| 8| 2| 0| 0| 4| 6| 6| 6| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 2 |
Mineralization, Multifocal | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 2 |
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 2 2 |
Infiltration Cellular, Lymphocyte | 2 |
Infiltration Cellular, | |
Polymorphonuclear | |
Infiltration Cellular, Histiocyte | 3 |
Alveolar Epithelium, Hyperplasia | 2 |
Glands, Dilatation | 3 2 |
Glands, Inflammation | |
Peribronchiolar, Cyst, Multifocal | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Multifocal | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | +|
Pinna, Inflammation, Focal | |
__________________________________________________________________________|
Eye | + + |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Multifocal | |
Hydronephrosis | |
Infarct, Focal | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 2 1 2 2 2 2|
Infiltration Cellular, | |
Polymorphonuclear | |
Inflammation, Acute, Multifocal | |
Nephropathy | 4 2 |
Pelvis, Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 6| 3| 5| 7| 7| 2| 7| 3| 7| 6| 7| 3| 7| 7| 7| 6| 3| 6| 7| 1| 7| 7| 7| 1| 7|
DAY ON TEST | 5| 9| 5| 3| 0| 8| 3| 8| 3| 9| 1| 8| 3| 3| 3| 8| 8| 2| 0| 3| 3| 3| 0| 8| 3|
| 2| 6| 8| 6| 6| 2| 6| 3| 6| 7| 4| 9| 6| 6| 6| 8| 2| 0| 0| 4| 6| 6| 6| 3| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Dilatation, Focal | 3 |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Mineralization, Focal | 1 1 |
__________________________________________________________________________|
Urethra | |
Distal, Dilatation | |
Epithelium, Necrosis, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + M + + + +|
Dilatation | 2 |
Hemorrhage | 3 3 |
Infiltration Cellular, | |
Polymorphonuclear | |
Inflammation, Acute | 3 |
Inflammation, Chronic Active | |
Transitional Epithelium, Hyperplasia,| |
Multifocal | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 2| 0| 3| 7| 3| 7| 1| 1| 3| 7| 4| 7| 0| 4| 7| 7| 7| 7| 7| 7| 0| 0| 7| 0| 0|
DAY ON TEST | 3| 4| 2| 3| 6| 3| 1| 5| 2| 3| 2| 3| 8| 6| 3| 3| 3| 3| 3| 3| 8| 8| 3| 8| 8|
| 5| 8| 7| 6| 1| 6| 2| 8| 0| 6| 1| 6| 3| 5| 6| 6| 6| 6| 6| 6| 8| 3| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + M + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A + M + + + A + + + + + + + A + + A M|
__________________________________________________________________________|
Intestine Large | + A A + + + A + A + + + + + + + + + + + A A + + M|
__________________________________________________________________________|
Intestine Large, Cecum | + A A + + + A + A + + + + + + + + + + + A A + A M|
Inflammation, Diffuse | |
__________________________________________________________________________|
Intestine Large, Colon | + A A + + + A + A + + + + + + + + + + + A A + A M|
__________________________________________________________________________|
Intestine Large, Rectum | + M A + + + A + A + + + + + + + + + + + A A + + M|
Diverticulum | |
Inflammation, Diffuse | |
__________________________________________________________________________|
Intestine Small | + A + + + + A + A + + + + + + + + + + + A A + A M|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + A + A + A + A + + + + + + + A A + A M|
__________________________________________________________________________|
Intestine Small, Ileum | + A A + + + A + A + + + + + + + + + + + A A + A M|
Inflammation, Multifocal | |
__________________________________________________________________________|
Intestine Small, Jejunum | A A A + + + A + A + A + + A + + + + + + A A + A M|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Fatty Change, Focal | |
Hematopoietic Cell Proliferation, | |
Focal | |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Necrosis, Multifocal | 3 |
Sinusoid, Ectasia, Focal | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis, Focal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + A|
Atrophy | 3 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 |
Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 2 |
Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Stomach | + A + + + + A + + + + + + + + + + + + + A + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + A + + + + A + + + + + + + + + + + + + A + + + A|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 2| 0| 3| 7| 3| 7| 1| 1| 3| 7| 4| 7| 0| 4| 7| 7| 7| 7| 7| 7| 0| 0| 7| 0| 0|
DAY ON TEST | 3| 4| 2| 3| 6| 3| 1| 5| 2| 3| 2| 3| 8| 6| 3| 3| 3| 3| 3| 3| 8| 8| 3| 8| 8|
| 5| 8| 7| 6| 1| 6| 2| 8| 0| 6| 1| 6| 3| 5| 6| 6| 6| 6| 6| 6| 8| 3| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + A + + + + A + M + + + + + + + + + + + A + + + A|
Infiltration Cellular, | |
Polymorphonuclear | |
Inflammation, Acute, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, | |
Polymorphonuclear | |
Myocardium, Inflammation, Multifocal | |
Valve, Pigmentation, Focal | 1 |
Valve, Pigmentation, Multifocal | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + M + M + +|
Capsule, Hyperplasia, Multifocal | 2 2 2 3 1 2 1 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + M + M + +|
Atrophy, Focal | |
Clear Cell Focus | |
Focal Cellular Change | |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + M + M + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + A|
Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Cyst, Focal | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + M + + M + + + + + + + + + M|
Pars Distalis, Congestion | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + M|
Infiltration Cellular, | |
Polymorphonuclear | |
Spermatocele, Focal | 3 |
__________________________________________________________________________|
Penis | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 2| 0| 3| 7| 3| 7| 1| 1| 3| 7| 4| 7| 0| 4| 7| 7| 7| 7| 7| 7| 0| 0| 7| 0| 0|
DAY ON TEST | 3| 4| 2| 3| 6| 3| 1| 5| 2| 3| 2| 3| 8| 6| 3| 3| 3| 3| 3| 3| 8| 8| 3| 8| 8|
| 5| 8| 7| 6| 1| 6| 2| 8| 0| 6| 1| 6| 3| 5| 6| 6| 6| 6| 6| 6| 8| 3| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Multifocal | |
__________________________________________________________________________|
Preputial Gland | + |
Inflammation | |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Prostate | + + + + + + A + + + + + + + + + + + + + + + + + M|
Infiltration Cellular, Lymphocyte | |
Infiltration Cellular, | |
Polymorphonuclear | |
Inflammation, Acute | 2 3 3 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + A + + + + + + + + + + + + + + + + + M|
Dilatation | 2 |
Inflammation, Focal | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + M|
Mineralization, Focal | 1 |
Bilateral, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 |
Thrombosis | |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + M M + + + M M M + + + M M M M + + M + + M + M +|
Hyperplasia, Lymphoid | |
Infiltration Cellular, | |
Polymorphonuclear | |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M M + + + M + + + + + + + + + + + +|
Angiectasis | |
Hemorrhage | |
Infiltration Cellular, | |
Polymorphonuclear | |
Pigmentation | 1 2 2 |
Lymphocyte, Necrosis, Multifocal | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + M + M M M M M M + M + M + M + + + M M + M M|
Infiltration Cellular, | |
Polymorphonuclear | |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + M M + + + + + + + M + + + + M + + + M|
Angiectasis | |
Erythrophagocytosis | 2 2 2 |
Giant Cell, Multifocal | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 2| 0| 3| 7| 3| 7| 1| 1| 3| 7| 4| 7| 0| 4| 7| 7| 7| 7| 7| 7| 0| 0| 7| 0| 0|
DAY ON TEST | 3| 4| 2| 3| 6| 3| 1| 5| 2| 3| 2| 3| 8| 6| 3| 3| 3| 3| 3| 3| 8| 8| 3| 8| 8|
| 5| 8| 7| 6| 1| 6| 2| 8| 0| 6| 1| 6| 3| 5| 6| 6| 6| 6| 6| 6| 8| 3| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | |
Granulocytic | 2 |
Hemorrhage | 3 2 2 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Infiltration Cellular, | |
Polymorphonuclear | |
Inflammation, Acute | |
Lymphocyte, Necrosis, Multifocal | 1 |
__________________________________________________________________________|
Spleen | + + + + + + A + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 2 2 |
Hematopoietic Cell Proliferation | |
Granulocytic | |
Hyperplasia, Lymphoid | |
Lymphocyte, Necrosis | 2 |
__________________________________________________________________________|
Thymus | + + + + + + M + M + + + M + + + + + + + M M + M +|
Cyst | X |
Depletion Lymphoid, Diffuse | |
Hyperplasia, Lymphoid, Multifocal | |
Thymocyte, Necrosis | 2 2 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | |
Cyst Epithelial Inclusion | |
Infiltration Cellular, | |
Polymorphonuclear | |
Inflammation, Focal | 4 2 3 |
Ulcer | 2 3 |
Prepuce, Inflammation, Chronic Active| 2 |
Prepuce, Ulcer | 3 4 4 |
Subcutaneous Tissue, Edema, Diffuse | |
Subcutaneous Tissue, Fibrosis, | |
Multifocal | |
Subcutaneous Tissue, Hemorrhage | 3 |
Tail, Inflammation, Multifocal, | |
Necrotizing | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Developmental Malformation | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 2| 0| 3| 7| 3| 7| 1| 1| 3| 7| 4| 7| 0| 4| 7| 7| 7| 7| 7| 7| 0| 0| 7| 0| 0|
DAY ON TEST | 3| 4| 2| 3| 6| 3| 1| 5| 2| 3| 2| 3| 8| 6| 3| 3| 3| 3| 3| 3| 8| 8| 3| 8| 8|
| 5| 8| 7| 6| 1| 6| 2| 8| 0| 6| 1| 6| 3| 5| 6| 6| 6| 6| 6| 6| 8| 3| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | |
Mineralization, Multifocal | 1 1 2 1 2 2 1 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + M + + + + + + + + + + + + + + + +|
Inflammation, Focal | |
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 3 3 2|
Hemorrhage | 2 2 |
Infiltration Cellular, Lymphocyte | 2 |
Infiltration Cellular, | |
Polymorphonuclear | |
Infiltration Cellular, Histiocyte | |
Alveolar Epithelium, Hyperplasia | |
Glands, Dilatation | |
Glands, Inflammation | 2 2 1 1 |
Peribronchiolar, Cyst, Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Multifocal | 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Pinna, Inflammation, Focal | |
__________________________________________________________________________|
Eye | +|
Lens, Cataract | 3|
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion, Multifocal | 2 |
Hydronephrosis | |
Infarct, Focal | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 3 2 2 2 2 |
Infiltration Cellular, | |
Polymorphonuclear | |
Inflammation, Acute, Multifocal | 3 2 |
Nephropathy | 2 1 |
Pelvis, Inflammation, Acute | 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 2| 0| 3| 7| 3| 7| 1| 1| 3| 7| 4| 7| 0| 4| 7| 7| 7| 7| 7| 7| 0| 0| 7| 0| 0|
DAY ON TEST | 3| 4| 2| 3| 6| 3| 1| 5| 2| 3| 2| 3| 8| 6| 3| 3| 3| 3| 3| 3| 8| 8| 3| 8| 8|
| 5| 8| 7| 6| 1| 6| 2| 8| 0| 6| 1| 6| 3| 5| 6| 6| 6| 6| 6| 6| 8| 3| 6| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Dilatation, Focal | |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Mineralization, Focal | |
__________________________________________________________________________|
Urethra | |
Distal, Dilatation | |
Epithelium, Necrosis, Multifocal | |
__________________________________________________________________________|
Urinary Bladder | + A A + + + A + + + + + + + + + + + + + A + + + M|
Dilatation | 3 |
Hemorrhage | |
Infiltration Cellular, | |
Polymorphonuclear | |
Inflammation, Acute | 3 |
Inflammation, Chronic Active | 4 3 |
Transitional Epithelium, Hyperplasia,| |
Multifocal | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 5| 0| 7| 5| 7| 0| 6| 7| 1| 7| 7| 0| 6| 6| 7| 7| 3| 7| 2| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 9| 8| 3| 8| 0| 4| 5| 3| 9| 1| 2| 1| 8| 5| 3| 3| 2| 3| 5| 3| |
| 4| 4| 4| 4| 4| 0| 4| 6| 9| 4| 8| 5| 6| 6| 5| 5| 5| 1| 4| 6| 6| 6| 6| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + M +| 66 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + A + + + + + + + + + + + + A +| 57 |
__________________________________________________________________________|____________|
Intestine Large | + A + + + A + + + + + + + + + + + + A +| 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + A + + A + + + + + + + + + A +| 56 |
Inflammation, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + M + A + + + + + + + + + + + + A +| 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + A + + A + + + + + + + + + A +| 58 |
Diverticulum | 3 | 1 3.0|
Inflammation, Diffuse | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + A + + A + + + + + + + + + A +| 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + A + + A + + + + + + + A + A +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + A + + A + + + + + + + A + A +| 51 |
Inflammation, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A A + + A + + + + + + + + + A +| 51 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + +| 70 |
Basophilic Focus | | 2 |
Fatty Change, Focal | | 2 2.0|
Hematopoietic Cell Proliferation, | | |
Focal | | 1 1.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2| 1 2.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | 4 | 1 4.0|
Necrosis, Multifocal | 3 2 | 4 2.8|
Sinusoid, Ectasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Fat, Necrosis, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + +| 67 |
Atrophy | | 3 2.3|
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 3 1.3|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1| 3 1.3|
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + M + + + + + + + + + + + + + + + +| 69 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 1.0|
Infiltration Cellular, Multifocal, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 5| 0| 7| 5| 7| 0| 6| 7| 1| 7| 7| 0| 6| 6| 7| 7| 3| 7| 2| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 9| 8| 3| 8| 0| 4| 5| 3| 9| 1| 2| 1| 8| 5| 3| 3| 2| 3| 5| 3| |
| 4| 4| 4| 4| 4| 0| 4| 6| 9| 4| 8| 5| 6| 6| 5| 5| 5| 1| 4| 6| 6| 6| 6| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Lymphocyte | 2| 13 1.8|
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + A + + + + + + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + + + A +| 63 |
Inflammation, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + +| 62 |
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Inflammation, Acute, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + +| 70 |
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Myocardium, Inflammation, Multifocal | | 1 2.0|
Valve, Pigmentation, Focal | | 5 1.4|
Valve, Pigmentation, Multifocal | 2 1| 4 1.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + M + + + + + + + + + + + + + + +| 66 |
Capsule, Hyperplasia, Multifocal | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 45 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + M + + + + + + + + + + + + + + +| 66 |
Atrophy, Focal | 3| 1 3.0|
Clear Cell Focus | | 1 |
Focal Cellular Change | | 1 2.0|
Hypertrophy, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + +| 66 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +| 67 |
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + M + + + + + + + + + + +| 64 |
Cyst, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + M M M + + M + M + + + M + M + + +| 52 |
Pars Distalis, Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +| 67 |
C-Cell, Hyperplasia | | 1 2.0|
Follicular Cell, Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 5| 0| 7| 5| 7| 0| 6| 7| 1| 7| 7| 0| 6| 6| 7| 7| 3| 7| 2| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 9| 8| 3| 8| 0| 4| 5| 3| 9| 1| 2| 1| 8| 5| 3| 3| 2| 3| 5| 3| |
| 4| 4| 4| 4| 4| 0| 4| 6| 9| 4| 8| 5| 6| 6| 5| 5| 5| 1| 4| 6| 6| 6| 6| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + +| 69 |
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Spermatocele, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Penis | + | 2 |
Inflammation, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + | 4 |
Inflammation | 4 | 1 4.0|
Duct, Dilatation | 3 | 3 2.7|
__________________________________________________________________________|____________|
Prostate | + + + M + + + + + + + + + + + + + + + +| 65 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Inflammation, Acute | 3 2 3 3 | 8 2.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + +| 66 |
Dilatation | 2 2 | 3 2.0|
Inflammation, Focal | 3 2 | 2 2.5|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + +| 69 |
Mineralization, Focal | | 4 1.0|
Bilateral, Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + | 3 |
Leukocytosis | 3 | 3 3.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +| 70 |
Hyperplasia | 2 | 9 2.4|
Thrombosis | X | 1 |
Myeloid Cell, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + M + M + + + M + M + + + + M + + M| 38 |
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Pigmentation | | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + + + M + M + + + + + M| 61 |
Angiectasis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 5| 0| 7| 5| 7| 0| 6| 7| 1| 7| 7| 0| 6| 6| 7| 7| 3| 7| 2| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 9| 8| 3| 8| 0| 4| 5| 3| 9| 1| 2| 1| 8| 5| 3| 3| 2| 3| 5| 3| |
| 4| 4| 4| 4| 4| 0| 4| 6| 9| 4| 8| 5| 6| 6| 5| 5| 5| 1| 4| 6| 6| 6| 6| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | | 1 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Pigmentation | 2 2 2 | 12 1.9|
Lymphocyte, Necrosis, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + M M M + M + + + + + + + + + + M +| 37 |
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Pigmentation | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + M + + + M + + + + + + +| 57 |
Angiectasis | 3 | 1 3.0|
Erythrophagocytosis | 2 2 2| 7 2.0|
Giant Cell, Multifocal | 2 2 2 2 | 11 2.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | 3 | 3 3.0|
Hemorrhage | 3 3 3 2 2 | 12 2.4|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Inflammation, Acute | | 3 2.0|
Lymphocyte, Necrosis, Multifocal | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + +| 69 |
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | 2 3 3 4 3 2 3 3 3 3| 20 3.0|
Hematopoietic Cell Proliferation | | |
Granulocytic | 4 | 1 4.0|
Hyperplasia, Lymphoid | | 1 2.0|
Lymphocyte, Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + + M + M M + + + + M + + + + M +| 47 |
Cyst | | 2 |
Depletion Lymphoid, Diffuse | | 1 4.0|
Hyperplasia, Lymphoid, Multifocal | | 1 2.0|
Thymocyte, Necrosis | 2 3 | 8 2.9|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M + M M M M M M + M M M M M +| 5 |
__________________________________________________________________________|____________|
Skin | + + + + + A + + + + + + + + + + + + + +| 69 |
Acanthosis, Focal | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 5| 0| 7| 5| 7| 0| 6| 7| 1| 7| 7| 0| 6| 6| 7| 7| 3| 7| 2| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 9| 8| 3| 8| 0| 4| 5| 3| 9| 1| 2| 1| 8| 5| 3| 3| 2| 3| 5| 3| |
| 4| 4| 4| 4| 4| 0| 4| 6| 9| 4| 8| 5| 6| 6| 5| 5| 5| 1| 4| 6| 6| 6| 6| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Cyst Epithelial Inclusion | | 1 |
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Inflammation, Focal | 3 | 5 2.8|
Ulcer | 4 | 4 3.0|
Prepuce, Inflammation, Chronic Active| | 1 2.0|
Prepuce, Ulcer | | 3 3.7|
Subcutaneous Tissue, Edema, Diffuse | 3 | 1 3.0|
Subcutaneous Tissue, Fibrosis, | | |
Multifocal | | 1 2.0|
Subcutaneous Tissue, Hemorrhage | | 1 3.0|
Tail, Inflammation, Multifocal, | | |
Necrotizing | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + +| 70 |
Vertebra, Developmental Malformation | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + +| 70 |
Mineralization, Focal | | 1 2.0|
Mineralization, Multifocal | 2 2 3 2 2 2 | 18 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + +| 69 |
Inflammation, Focal | | 1 2.0|
Epithelium, Hyperplasia, Focal | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + +| 70 |
Congestion | 2 3 3 | 9 2.8|
Hemorrhage | | 4 2.0|
Infiltration Cellular, Lymphocyte | 1 | 3 1.7|
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 1 | 2 1.5|
Glands, Dilatation | | 2 2.5|
Glands, Inflammation | 1 2 1 | 7 1.4|
Peribronchiolar, Cyst, Multifocal | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + +| 70 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 5| 0| 7| 5| 7| 0| 6| 7| 1| 7| 7| 0| 6| 6| 7| 7| 3| 7| 2| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 9| 8| 3| 8| 0| 4| 5| 3| 9| 1| 2| 1| 8| 5| 3| 3| 2| 3| 5| 3| |
| 4| 4| 4| 4| 4| 0| 4| 6| 9| 4| 8| 5| 6| 6| 5| 5| 5| 1| 4| 6| 6| 6| 6| 5| 6| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Congestion, Multifocal | 2 | 3 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + +| 70 |
Glands, Dilatation | | 2 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
Pinna, Inflammation, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Eye | | 3 |
Lens, Cataract | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + +| 70 |
Congestion, Multifocal | | 1 2.0|
Hydronephrosis | 3 | 1 3.0|
Infarct, Focal | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 2 2 | 17 1.9|
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Inflammation, Acute, Multifocal | | 2 2.5|
Nephropathy | 2 1| 6 2.0|
Pelvis, Inflammation, Acute | | 3 2.0|
Renal Tubule, Dilatation, Focal | | 1 3.0|
Renal Tubule, Hyperplasia, Focal | 3 | 1 3.0|
Renal Tubule, Mineralization, Focal | 2 2 | 4 1.5|
__________________________________________________________________________|____________|
Urethra | + | 1 |
Distal, Dilatation | 3 | 1 3.0|
Epithelium, Necrosis, Multifocal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + A + + + + + + + + + M + + A +| 60 |
Dilatation | 3 2 2 3 2 | 7 2.4|
Hemorrhage | | 2 3.0|
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Inflammation, Acute | 2 | 3 2.7|
Inflammation, Chronic Active | 3 | 3 3.3|
Transitional Epithelium, Hyperplasia,| | |
Multifocal | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 0| 2| 6| 1| 2| 3| 3| 0| 5| 3| 6| 7| 7| 7| 7| 0| 6| 0| 0| 0| 0| 0| 7| 7| 7|
DAY ON TEST | 1| 8| 4| 1| 6| 0| 3| 3| 3| 7| 9| 4| 4| 4| 4| 3| 9| 1| 1| 1| 1| 1| 4| 4| 4|
| 4| 7| 0| 9| 5| 3| 0| 0| 6| 2| 2| 4| 4| 4| 4| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
10 PPM | 1| 2| 2| 3| 3| 3| 3| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 7| 7| 7| 7| 7| 8| 8| 8|
| 1| 1| 2| 1| 2| 3| 4| 1| 2| 1| 1| 2| 3| 4| 5| 1| 1| 1| 2| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + M M + |
__________________________________________________________________________|
Gallbladder | A + A + A + + + A + |
Dilatation | |
__________________________________________________________________________|
Intestine Large | A + + + A + + + A + |
__________________________________________________________________________|
Intestine Large, Cecum | A A + + A A + + A + |
__________________________________________________________________________|
Intestine Large, Colon | A + + + A + + + A + |
__________________________________________________________________________|
Intestine Large, Rectum | A M + + A A + + A + |
__________________________________________________________________________|
Intestine Small | A A + + A A + + A + |
Serosa, Fibrosis | |
__________________________________________________________________________|
Intestine Small, Duodenum | A A A + A A + + A + |
__________________________________________________________________________|
Intestine Small, Ileum | A M + + A A + + A + |
__________________________________________________________________________|
Intestine Small, Jejunum | A M + + A A + + A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + +|
Degeneration, Focal | |
Necrosis, Focal | 2 |
Necrosis, Multifocal | |
Serosa, Fibrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + |
Inflammation, Chronic Active, Diffuse| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + M |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Stomach | A + + + + + + + A + |
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + A + |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + A + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + M + + +|
Capsule, Hyperplasia, Multifocal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + M + |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + + M M + + M + |
__________________________________________________________________________|
Pituitary Gland | M + + + M M + M M + |
__________________________________________________________________________|
Thyroid Gland | + + + + M + + + A + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 0| 2| 6| 1| 2| 3| 3| 0| 5| 3| 6| 7| 7| 7| 7| 0| 6| 0| 0| 0| 0| 0| 7| 7| 7|
DAY ON TEST | 1| 8| 4| 1| 6| 0| 3| 3| 3| 7| 9| 4| 4| 4| 4| 3| 9| 1| 1| 1| 1| 1| 4| 4| 4|
| 4| 7| 0| 9| 5| 3| 0| 0| 6| 2| 2| 4| 4| 4| 4| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
10 PPM | 1| 2| 2| 3| 3| 3| 3| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 7| 7| 7| 7| 7| 8| 8| 8|
| 1| 1| 2| 1| 2| 3| 4| 1| 2| 1| 1| 2| 3| 4| 5| 1| 1| 1| 2| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ductus Deferens | |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + M + |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Acute | 2 2 |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + M + + + + + |
Dilatation | 2 |
Serosa, Inflammation, Chronic | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + |
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M + + M M M M M |
Hyperplasia, Lymphoid | |
Lymphocyte, Necrosis | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + M |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M M M M M + + |
Hyperplasia, Lymphoid | 2 |
Inflammation, Acute | |
__________________________________________________________________________|
Lymph Node, Mesenteric | A M + + M M M + M M |
__________________________________________________________________________|
Spleen | + + + + + + + + A + |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 2 2 2 |
Hyperplasia, Lymphoid | |
Capsule, Fibrosis | |
__________________________________________________________________________|
Thymus | M M M + M M M M M M |
Thymocyte, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + |
Inflammation, Focal | 2 4 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 0| 2| 6| 1| 2| 3| 3| 0| 5| 3| 6| 7| 7| 7| 7| 0| 6| 0| 0| 0| 0| 0| 7| 7| 7|
DAY ON TEST | 1| 8| 4| 1| 6| 0| 3| 3| 3| 7| 9| 4| 4| 4| 4| 3| 9| 1| 1| 1| 1| 1| 4| 4| 4|
| 4| 7| 0| 9| 5| 3| 0| 0| 6| 2| 2| 4| 4| 4| 4| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
10 PPM | 1| 2| 2| 3| 3| 3| 3| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 7| 7| 7| 7| 7| 8| 8| 8|
| 1| 1| 2| 1| 2| 3| 4| 1| 2| 1| 1| 2| 3| 4| 5| 1| 1| 1| 2| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + |
Vertebra, Fracture Healed | X |
__________________________________________________________________________|
Skeletal Muscle | + + |
Inflammation, Chronic | 4 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + |
Mineralization, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + A + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 2 2 1 2 |
Inflammation, Granulomatous | 2 2 2 3 2 3|
Inflammation | 2 3 3 2 2 |
Alveolar Epithelium, Hyperplasia | 1 |
Glands, Inflammation | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 2 1 2 1 2 2 2 3 2 2 2 1 3 2 3 3|
Olfactory Epithelium, Metaplasia | 2 2 2 2 2 1 3 2 2 4 2 3 2 3 3 3 3|
Respiratory Epithelium, Hyperplasia | 3 1 3 2 3 1 3 2 3 3 2 3 2 3 3 3 2|
__________________________________________________________________________|
Trachea | + + + + M + + + + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Degeneration | |
__________________________________________________________________________|
Harderian Gland | |
Cyst, Multiple | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + |
Degeneration | |
Hydronephrosis | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 |
Inflammation, Acute, Multifocal | |
Nephropathy | 2 |
Renal Tubule, Dilatation, Focal | |
Renal Tubule, Mineralization, Focal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + M + |
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 0| 2| 6| 1| 2| 3| 3| 0| 5| 3| 6| 7| 7| 7| 7| 0| 6| 0| 0| 0| 0| 0| 7| 7| 7|
DAY ON TEST | 1| 8| 4| 1| 6| 0| 3| 3| 3| 7| 9| 4| 4| 4| 4| 3| 9| 1| 1| 1| 1| 1| 4| 4| 4|
| 4| 7| 0| 9| 5| 3| 0| 0| 6| 2| 2| 4| 4| 4| 4| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
10 PPM | 1| 2| 2| 3| 3| 3| 3| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 7| 7| 7| 7| 7| 8| 8| 8|
| 1| 1| 2| 1| 2| 3| 4| 1| 2| 1| 1| 2| 3| 4| 5| 1| 1| 1| 2| 3| 4| 5| 1| 2| 3|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | 3 |
Serosa, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 6| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 4| 3| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 4| 9| 7| 8| 4| 4| 4| 9| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 8| 8| 8| 8| 9| 9| 0| 0| 0| 3| 3| 4|
| 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 2| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Gallbladder | |
Dilatation | |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
__________________________________________________________________________|
Intestine Large, Colon | |
__________________________________________________________________________|
Intestine Large, Rectum | |
__________________________________________________________________________|
Intestine Small | + + + |
Serosa, Fibrosis | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + |
__________________________________________________________________________|
Intestine Small, Ileum | + |
__________________________________________________________________________|
Intestine Small, Jejunum | |
__________________________________________________________________________|
Liver | + + + + + + + |
Degeneration, Focal | |
Necrosis, Focal | |
Necrosis, Multifocal | 3 |
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Pancreas | |
Inflammation, Chronic Active, Diffuse| |
__________________________________________________________________________|
Salivary Glands | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
__________________________________________________________________________|
Stomach | |
__________________________________________________________________________|
Stomach, Forestomach | |
__________________________________________________________________________|
Stomach, Glandular | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
Capsule, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | |
__________________________________________________________________________|
Parathyroid Gland | |
__________________________________________________________________________|
Pituitary Gland | |
__________________________________________________________________________|
Thyroid Gland | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 6| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 4| 3| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 4| 9| 7| 8| 4| 4| 4| 9| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 8| 8| 8| 8| 9| 9| 0| 0| 0| 3| 3| 4|
| 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 2| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Ductus Deferens | + |
Serosa, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Epididymis | + |
Serosa, Inflammation, Chronic | 2 |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + |
Infiltration Cellular, Lymphocyte | |
Inflammation, Acute | |
Serosa, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + |
Dilatation | |
Serosa, Inflammation, Chronic | 3 |
__________________________________________________________________________|
Testes | + |
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | |
__________________________________________________________________________|
Lymph Node | + + |
__________________________________________________________________________|
Lymph Node, Bronchial | |
Hyperplasia, Lymphoid | |
Lymphocyte, Necrosis | |
__________________________________________________________________________|
Lymph Node, Mandibular | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + |
Hyperplasia, Lymphoid | |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
__________________________________________________________________________|
Spleen | + + + + + |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 3 |
Capsule, Fibrosis | 3 |
__________________________________________________________________________|
Thymus | |
Thymocyte, Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | |
__________________________________________________________________________|
Skin | + + + + |
Inflammation, Focal | |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 6| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 4| 3| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 4| 9| 7| 8| 4| 4| 4| 9| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 8| 8| 8| 8| 9| 9| 0| 0| 0| 3| 3| 4|
| 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 2| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | |
Vertebra, Fracture Healed | |
__________________________________________________________________________|
Skeletal Muscle | + + |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
Mineralization, Multifocal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 2 2 2 1 2 |
Inflammation, Granulomatous | 3 2 2 2 2 2 2 |
Inflammation | 3 2 2 2 3 2 2|
Alveolar Epithelium, Hyperplasia | 1 2 2 2 2 |
Glands, Inflammation | 2 2 3 3 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 2 3 3 2 2 2 2 3 3 3 3 2 3 2 3 2 3 1 3 2 2 2 2|
Olfactory Epithelium, Metaplasia | 3 2 2 3 2 3 3 4 3 3 3 2 3 2 2 3 2 3 3 3 3 2 2 3|
Respiratory Epithelium, Hyperplasia | 3 2 3 3 2 3 3 3 3 3 4 2 3 2 2 3 2 2 2 3 2 3 3 3|
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | |
Cyst, Multiple | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + +|
Degeneration | 4 |
Hydronephrosis | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation, Acute, Multifocal | |
Nephropathy | 3|
Renal Tubule, Dilatation, Focal | |
Renal Tubule, Mineralization, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + |
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 6| 1| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 2| 4| 3| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 4| 9| 7| 8| 4| 4| 4| 9| 4| 4| 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
10 PPM | 8| 8| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 8| 8| 8| 8| 9| 9| 0| 0| 0| 3| 3| 4|
| 4| 5| 1| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 1| 2| 3| 1| 2| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Chronic Active | |
Serosa, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 3| 4| |
| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
10 PPM | 4| 4| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 4| 7| 9| 9| 9| L |
| 2| 3| 1| 2| 3| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 1| 2| 3| 1| 1| 1| 2| 3| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 7 |
__________________________________________________________________________|____________|
Gallbladder | + | 7 |
Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | | 7 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 7 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 5 |
__________________________________________________________________________|____________|
Intestine Small | | 8 |
Serosa, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 6 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + +| 33 |
Degeneration, Focal | 2| 1 2.0|
Necrosis, Focal | 1| 2 1.5|
Necrosis, Multifocal | 2 | 2 2.5|
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + | 10 |
Inflammation, Chronic Active, Diffuse| 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 11 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | | 11 |
Capsule, Hyperplasia, Multifocal | | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | | 9 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | | 11 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | | 9 |
__________________________________________________________________________|____________|
Parathyroid Gland | | 6 |
__________________________________________________________________________|____________|
Pituitary Gland | | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 3| 4| |
| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
10 PPM | 4| 4| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 4| 7| 9| 9| 9| L |
| 2| 3| 1| 2| 3| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 1| 2| 3| 1| 1| 1| 2| 3| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ductus Deferens | | 1 |
Serosa, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Epididymis | | 11 |
Serosa, Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Penis | | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
Duct, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + | 11 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Acute | | 2 2.0|
Serosa, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 16 |
Dilatation | 2 | 2 2.0|
Serosa, Inflammation, Chronic | 2 | 2 2.5|
__________________________________________________________________________|____________|
Testes | | 12 |
Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | | 10 |
__________________________________________________________________________|____________|
Lymph Node | + + | 14 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + | 5 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
Lymphocyte, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 8 |
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | | 4 |
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + | 18 |
Depletion Lymphoid | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 | 5 2.4|
Hyperplasia, Lymphoid | | 1 3.0|
Capsule, Fibrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | | 1 |
Thymocyte, Necrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 3| 4| |
| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
10 PPM | 4| 4| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 4| 7| 9| 9| 9| L |
| 2| 3| 1| 2| 3| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 1| 2| 3| 1| 1| 1| 2| 3| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | | |
__________________________________________________________________________|____________|
Skin | + + + + | 21 |
Inflammation, Focal | | 2 3.0|
Ulcer | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 11 |
Vertebra, Fracture Healed | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 4 |
Inflammation, Chronic | | 3 3.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 10 |
Mineralization, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | | 9 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 69 |
Congestion | | 1 3.0|
Hemorrhage | 2 1 3 | 3 2.0|
Infiltration Cellular, Histiocyte | 2 | 12 1.8|
Inflammation, Granulomatous | 3 2 2 3 1 2| 19 2.2|
Inflammation | 1 3 2 3 2 3 2 2 3 | 21 2.3|
Alveolar Epithelium, Hyperplasia | 2 | 7 1.7|
Glands, Inflammation | 2 2 3 2 2 | 14 2.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 69 |
Inflammation | 2 2 2 3 2 3 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 3| 67 2.2|
Olfactory Epithelium, Metaplasia | 2 2 3 3 2 3 3 3 3 2 3 3 2 4 2 2 2 2 2 2 2 2 3 3 3| 66 2.5|
Respiratory Epithelium, Hyperplasia | 2 2 3 3 2 3 3 4 3 2 2 3 2 3 2 2 2 2 2 2 2 3 3 3 3| 66 2.6|
__________________________________________________________________________|____________|
Trachea | | 9 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Cyst, Multiple | X | 1 |
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 3| 4| |
| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 0| 7| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
10 PPM | 4| 4| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 1| 1| 1| 4| 7| 9| 9| 9| L |
| 2| 3| 1| 2| 3| 1| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 1| 2| 3| 1| 1| 1| 2| 3| |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 16 |
Degeneration | | 1 4.0|
Hydronephrosis | 3 | 1 3.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 2 2.0|
Inflammation, Acute, Multifocal | 3 | 1 3.0|
Nephropathy | | 2 2.5|
Renal Tubule, Dilatation, Focal | 3 | 1 3.0|
Renal Tubule, Mineralization, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 16 |
Dilatation | 3 3 3 3 3 | 6 3.0|
Inflammation, Chronic Active | 2 | 2 2.5|
Serosa, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 2| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 5|
DAY ON TEST | 3| 3| 3| 3| 8| 8| 3| 3| 3| 0| 4| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 4|
| 8| 8| 8| 8| 2| 0| 8| 8| 8| 2| 4| 8| 8| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + M + + + M +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + + + A + + + M + + M + M + M + +|
Epithelium, Hyperplasia, Focal, | |
Papillary | |
__________________________________________________________________________|
Intestine Large | + + + + + A + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + A + + + + + + + + + + + + +|
Hyperplasia, Focal, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + A + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + A + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + A + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + A + + + + + + + + + + + + +|
Submucosa, Dilatation, Focal | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A A + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Basophilic Focus, Multifocal | X |
Clear Cell Focus | |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation, | |
Focal | |
Hematopoietic Cell Proliferation, | |
Multifocal | 1 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Mineralization, Focal | |
Mixed Cell Focus | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + A + + + + + + + + + + + + +|
Atrophy | |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 2|
Inflammation, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 2 1 2 2 2|
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 3 1 2 |
__________________________________________________________________________|
Stomach | + + + + + A + + + + A + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 2| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 5|
DAY ON TEST | 3| 3| 3| 3| 8| 8| 3| 3| 3| 0| 4| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 4|
| 8| 8| 8| 8| 2| 0| 8| 8| 8| 2| 4| 8| 8| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + A + + + + A + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + A + + + + + + + + + + + + +|
Inflammation, Acute, Focal | |
Mineralization, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Valve, Pigmentation, Focal | 2 2 |
Valve, Pigmentation, Multifocal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + M + + + + + + + + + + + + +|
Capsule, Hyperplasia, Focal | 2 2 |
Capsule, Hyperplasia, Multifocal | 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + M + + + + + + + + + + + + +|
Cyst | X |
Focal Cellular Change | X |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + M + + + + + + + + + + + M +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + A + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Polymorphonuclear | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + M + + + + + + + + + + + + + + +|
Cyst, Focal | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + M + + + + + + + + + + + M +|
Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + +|
Cyst | |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Duct, Dilatation, Focal | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 2| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 5|
DAY ON TEST | 3| 3| 3| 3| 8| 8| 3| 3| 3| 0| 4| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 4|
| 8| 8| 8| 8| 2| 0| 8| 8| 8| 2| 4| 8| 8| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | 3 |
Mineralization, Focal | |
Thrombosis, Focal | |
Interstitial Cell, Hyperplasia, | |
Multifocal | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 3 |
Hemorrhage, Focal | |
Hyperplasia | |
Myelofibrosis, Focal | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + M + + M + M + +|
Giant Cell, Multifocal | |
Hyperplasia, Lymphoid | 3 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + M + + M M + + + + + + + M + + +|
Hyperplasia, Lymphoid | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + M M + + + + M + + + + + + + M M + M +|
Hyperplasia, Lymphoid | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + +|
Erythrophagocytosis | 2 2 |
Giant Cell, Multifocal | 2 2 2 2 |
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | 4 3 |
Lymphocyte, Necrosis, Multifocal | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 |
Lymphocyte, Necrosis | 2 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + M + + + + + + + + M + + + +|
Cyst | |
Cyst, Multifocal | X |
Thymocyte, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | |
Inflammation, Focal | 3 |
Sweat Gland, Ectasia, Multifocal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 2| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 5|
DAY ON TEST | 3| 3| 3| 3| 8| 8| 3| 3| 3| 0| 4| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 4|
| 8| 8| 8| 8| 2| 0| 8| 8| 8| 2| 4| 8| 8| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 |
Mineralization, Multifocal | 2 2 2 2 2 2 2|
Olfactory Lobe, Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + M + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 2 |
Infiltration Cellular, Lymphocyte | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 2 2 2 |
Inflammation, Granulomatous | 3 3 |
Inflammation | 2 1 3 3 3 1 1 2 2 3 2|
Alveolar Epithelium, Hyperplasia | 3 3 1 1 |
Glands, Inflammation | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation | 2 2 3 2 2 2 4 2 4 2 3 3 3 2 2 3 3 2 2 2 3 2 2|
Olfactory Epithelium, Metaplasia | 3 2 2 4 3 3 3 3 3 3 2 2 2 3 2 3 3 2 2 3 3 2 3 3|
Respiratory Epithelium, Hyperplasia | 2 3 3 2 2 2 4 4 3 3 3 3 3 2 2 3 3 3 3 3 2 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Dilatation | |
Glands, Infiltration Cellular, Focal,| |
Lymphocyte | |
Glands, Inflammation, Focal, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + +|
Dysplasia, Multifocal | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct, Focal | |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 2 |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 1| 2| 7| 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 5|
DAY ON TEST | 3| 3| 3| 3| 8| 8| 3| 3| 3| 0| 4| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 9| 4|
| 8| 8| 8| 8| 2| 0| 8| 8| 8| 2| 4| 8| 8| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 2 2 1 2 2 2 1 |
Nephropathy | 2 2 2 |
Renal Tubule, Dilatation, Focal | 3 |
Renal Tubule, Hyperplasia, Focal | |
Renal Tubule, Mineralization, Focal | |
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 2 2 |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal, | |
Papillary | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Submucosa, Dilatation, Focal | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Basophilic Focus, Multifocal | |
Clear Cell Focus | |
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation, | |
Focal | |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Mineralization, Focal | 3 |
Mixed Cell Focus | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 1 2 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute, Focal | 1 |
Mineralization, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Valve, Pigmentation, Focal | 2 2 2 |
Valve, Pigmentation, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia, Focal | |
Capsule, Hyperplasia, Multifocal | 2 2 3 2 3 2 2 2 2 2 2 2 2 2 3 2 2 2 2 3 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Focal Cellular Change | 2 |
Hypertrophy, Focal | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Polymorphonuclear | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + M + + + + + + +|
Cyst, Focal | 2 X|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + M + + M + + + + + +|
Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Follicular Cell, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Duct, Dilatation, Focal | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Atrophy | |
Mineralization, Focal | |
Thrombosis, Focal | |
Interstitial Cell, Hyperplasia, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Hemorrhage, Focal | 2 |
Hyperplasia | 2 |
Myelofibrosis, Focal | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M + + + + + + + + + + + + + + + + + +|
Giant Cell, Multifocal | |
Hyperplasia, Lymphoid | 3 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 |
Pigmentation | 2 2 1|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M M M + + + + + + M M + M M + + M + + + + M +|
Hyperplasia, Lymphoid | 3 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythrophagocytosis | 2 2 2 2 2 2 2|
Giant Cell, Multifocal | 2 2 2 2 2 2 2 2 3 2 2 2|
Hemorrhage | 2 2 2 2 2 1 2 |
Hyperplasia, Lymphoid | 3 3 |
Lymphocyte, Necrosis, Multifocal | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Lymphocyte, Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Cyst, Multifocal | 2 |
Thymocyte, Necrosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | |
Inflammation, Focal | |
Sweat Gland, Ectasia, Multifocal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 2 2 1 |
Mineralization, Multifocal | 1 2 2 2 1 2 2 2 1 2 2 2 2 2|
Olfactory Lobe, Hemorrhage, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + M + + + M + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 2 |
Infiltration Cellular, Lymphocyte | 3 2 |
Infiltration Cellular, Histiocyte | 1 2 2 2 1 |
Inflammation, Granulomatous | |
Inflammation | 2 2 3 3 2 2 2 2 3|
Alveolar Epithelium, Hyperplasia | 2 |
Glands, Inflammation | 2 1 2 2 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation | 4 4 4 3 3 2 2 4 3 2 2 4 2 3 2 2 3 2 3 2 4 2 2 2 3|
Olfactory Epithelium, Metaplasia | 3 4 3 3 3 3 3 3 2 2 3 2 3 3 3 3 3 3 3 3 2 3 2 2 3|
Respiratory Epithelium, Hyperplasia | 4 4 3 4 3 3 3 4 3 2 3 3 4 4 3 2 3 3 4 3 3 3 2 3 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Dilatation | 2 |
Glands, Infiltration Cellular, Focal,| |
Lymphocyte | 2 |
Glands, Inflammation, Focal, | |
Suppurative | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Dysplasia, Multifocal | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct, Focal | |
Infiltration Cellular, Focal, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 1 2 1 2 2 2 2 2 2|
Nephropathy | 2 2 |
Renal Tubule, Dilatation, Focal | 2 2 |
Renal Tubule, Hyperplasia, Focal | 1 2 1 |
Renal Tubule, Mineralization, Focal | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 1 |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 4| 4| 9| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 4| 4| 4| 4| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + +| 61 |
Epithelium, Hyperplasia, Focal, | | |
Papillary | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +| 65 |
Hyperplasia, Focal, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +| 65 |
Parasite Metazoan | X X | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +| 64 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + M + + + + + + + + + + + + + + + +| 64 |
Submucosa, Dilatation, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + +| 67 |
Basophilic Focus | X | 5 |
Basophilic Focus, Multifocal | | 1 |
Clear Cell Focus | X | 1 |
Fibrosis, Focal | | 1 3.0|
Hematopoietic Cell Proliferation, | | |
Focal | 1 1 | 2 1.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | | 1 1.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 2| 3 1.7|
Mineralization, Focal | | 1 3.0|
Mixed Cell Focus | X | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + +| 66 |
Atrophy | | 1 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 3 1.7|
Inflammation, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 4| 4| 9| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 4| 4| 4| 4| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 | 8 1.8|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 1 2 2| 14 1.7|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + +| 65 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +| 65 |
Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +| 65 |
Inflammation, Acute, Focal | | 1 1.0|
Mineralization, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + +| 67 |
Valve, Pigmentation, Focal | 2 2 | 7 2.0|
Valve, Pigmentation, Multifocal | 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + M + + + + + + + + + + +| 65 |
Capsule, Hyperplasia, Focal | 2 | 3 2.0|
Capsule, Hyperplasia, Multifocal | 2 1 1 2 1 2 2 2 2 2 2 2 | 49 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + M + + + + + + + + + + +| 65 |
Cyst | | 1 |
Focal Cellular Change | 2 | 3 2.0|
Hypertrophy, Focal | 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + + +| 64 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +| 66 |
Infiltration Cellular, Focal, | | |
Polymorphonuclear | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + +| 62 |
Cyst, Focal | 2 | 4 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + + + + + + + M M| 58 |
Cyst | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +| 66 |
Cyst | | 1 |
Follicular Cell, Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 4| 4| 9| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 4| 4| 4| 4| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + +| 67 |
Granuloma Sperm | 3 | 2 3.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Duct, Dilatation, Focal | 2 | 2 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + +| 67 |
Angiectasis, Focal | 2 | 1 2.0|
Atrophy | | 1 3.0|
Mineralization, Focal | 2 2 | 2 2.0|
Thrombosis, Focal | 2 | 1 2.0|
Interstitial Cell, Hyperplasia, | | |
Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + +| 67 |
Angiectasis, Focal | | 1 3.0|
Hemorrhage, Focal | | 1 2.0|
Hyperplasia | | 1 2.0|
Myelofibrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + +| 67 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M M M + + + M + + + + + + + + M| 57 |
Giant Cell, Multifocal | 2 2 | 2 2.0|
Hyperplasia, Lymphoid | | 2 3.0|
Pigmentation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + M + + +| 59 |
Hyperplasia, Lymphoid | | 2 2.5|
Pigmentation | 2 1 | 5 1.6|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + M M M M + + M M M M + +| 43 |
Hyperplasia, Lymphoid | | 1 3.0|
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +| 66 |
Erythrophagocytosis | 2 2 2 3| 13 2.1|
Giant Cell, Multifocal | 2 2 1 2 2 2 2 2| 24 2.0|
Hemorrhage | 2 1 2 3 2 2 2| 16 1.9|
Hyperplasia, Lymphoid | | 4 3.3|
Lymphocyte, Necrosis, Multifocal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 4| 4| 9| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 4| 4| 4| 4| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + +| 67 |
Hyperplasia, Lymphoid | | 2 2.0|
Lymphocyte, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + + + +| 63 |
Cyst | 2 2 | 4 2.0|
Cyst, Multifocal | | 2 2.0|
Thymocyte, Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M + M M M M M M M M M M| 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + +| 67 |
Acanthosis, Focal | 2 | 1 2.0|
Inflammation, Focal | | 1 3.0|
Sweat Gland, Ectasia, Multifocal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + +| 67 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + +| 67 |
Mineralization, Focal | 1 2 | 7 1.4|
Mineralization, Multifocal | 2 1 2 1 | 25 1.8|
Olfactory Lobe, Hemorrhage, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + +| 64 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + +| 67 |
Hemorrhage | | 5 1.8|
Infiltration Cellular, Lymphocyte | 2| 4 2.3|
Infiltration Cellular, Histiocyte | | 11 1.5|
Inflammation, Granulomatous | 2 | 3 2.7|
Inflammation | 2 3 1 1 1 1 2 2| 28 2.0|
Alveolar Epithelium, Hyperplasia | 1 1 2 | 8 1.8|
Glands, Inflammation | 2 2 2 2 2 2 | 14 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + +| 67 |
Hemorrhage | 2 | 1 2.0|
Inflammation | 2 2 2 3 3 2 2 4 2 2 3 2 2 2 3 2 2 3| 66 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 4| 4| 4| 9| 4| 4| 4| 4| 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| |
| 4| 4| 4| 4| 4| 2| 2| 2| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Olfactory Epithelium, Metaplasia | 2 3 3 3 3 2 2 3 3 2 3 4 2 2 3 3 2 2| 67 2.7|
Respiratory Epithelium, Hyperplasia | 2 2 2 4 3 2 3 4 3 2 2 2 2 2 4 4 3 3| 67 2.9|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + +| 67 |
Glands, Dilatation | | 1 2.0|
Glands, Infiltration Cellular, Focal,| | |
Lymphocyte | | 1 2.0|
Glands, Inflammation, Focal, | | |
Suppurative | 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 4 |
Dysplasia, Multifocal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + +| 67 |
Infarct, Focal | 2 | 1 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 1 | 3 1.7|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 2 1 2 1 1 2 2 2 1 | 30 1.6|
Nephropathy | 1 1 2| 8 1.8|
Renal Tubule, Dilatation, Focal | | 3 2.3|
Renal Tubule, Hyperplasia, Focal | | 3 1.3|
Renal Tubule, Mineralization, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +| 66 |
Dilatation | 3 3| 3 3.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 | 6 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 9| 4| 4| 7| 0| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + A + M + + + + A + + + + + + + + + +|
Hemorrhage, Focal | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + A + + + + + + + + + +|
Hyperplasia, Focal, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + M + + + + A + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Prolapse | X |
__________________________________________________________________________|
Intestine Small | + + + + + + A A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A A + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Clear Cell Focus, Multifocal | |
Cyst, Focal | |
Cytoplasmic Alteration, Focal | 2 |
Degeneration, Focal | 3 |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation, | |
Focal | 1 1 |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Hemorrhage, Focal | |
Infarct, Focal | 4 |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 1 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Mixed Cell Focus | |
Necrosis, Multifocal | |
Thrombosis, Multifocal | 3 |
Hepatocyte, Cytomegaly, Focal | |
Sinusoid, Ectasia, Focal | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 9| 4| 4| 7| 0| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Lymphocyte | 1 1|
Inflammation, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Multifocal | |
Infiltration Cellular, Focal, | |
Lymphocyte | 1 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 1 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Focal | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Multifocal | |
Valve, Pigmentation, Focal | 1 1|
Valve, Pigmentation, Multifocal | |
Ventricle, Thrombosis, Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia, Focal | 2 |
Capsule, Hyperplasia, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular, Focal | |
Giant Cell, Multifocal | |
Hyperplasia, Focal | |
Hypertrophy, Focal | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Cyst, Focal | |
Ectopic Tissue | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + M M + + M + M + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Follicle, Dilatation, Focal | 2 |
Follicular Cell, Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 9| 4| 4| 7| 0| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Inflammation, Focal | 1 |
Spermatocele, Focal | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + |
Hyperplasia | 2 |
Inflammation | 3 |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Acute | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Focal | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Mineralization, Focal | 2 2 |
Bilateral, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
Leukocytosis | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage, Focal | |
Hyperplasia | 3 3 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M + M M M + + + + M + + M M M + + M + + +|
Giant Cell, Multifocal | |
Pigmentation | 1 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 2 1 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + + M + + + + + + + + + + + + + + + M M M|
Hyperplasia, Lymphoid | |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M M + + + + + + + + + + + + + + + + + +|
Erythrophagocytosis | 2 2 2 2 2 |
Giant Cell, Multifocal | 2 2 2 2 1 2 2 |
Hemorrhage | 2 2 3 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hematopoietic Cell Proliferation | 3 3 2 2 |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 9| 4| 4| 7| 0| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +|
Cyst | |
Cyst, Multifocal | 2 |
Ectopic Parathyroid Gland, Focal | |
Epithelial Cell, Cytoplasmic | |
Alteration, Focal | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 2 |
Lymphatic, Dilatation | 3 3 |
Subcutaneous Tissue, Angiectasis | 2 |
Subcutaneous Tissue, Fibrosis, | |
Multifocal | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 |
Mineralization, Multifocal | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 |
Infiltration Cellular, Histiocyte | 1 2 2 |
Inflammation, Granulomatous | 3 3 2 2 2 |
Inflammation | 2 2 2 3 1 |
Alveolar Epithelium, Hyperplasia | 1 1 |
Glands, Inflammation | 3 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 4 3 2 3 3 4 4 2 4 3 3 2 2 2 3 2 2 3 2 2 2 3 2 3|
Olfactory Epithelium, Metaplasia | 2 2 2 1 2 2 2 2 3 3 3 4 3 3 2 2 2 2 4 2 2 1 3 2 2|
Respiratory Epithelium, Hyperplasia | 2 4 2 3 2 3 3 2 2 3 2 4 4 2 2 3 3 3 3 2 3 2 2 3 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 9| 4| 4| 7| 0| 4| 4| 4| 4| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
| 2| 2| 2| 3| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cornea, Inflammation, Focal | |
Iris, Hyperplasia, Multifocal, | |
Melanocyte | |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | 3 |
Infarct, Focal | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 1 2 2 2 2 |
Inflammation, Acute, Multifocal | |
Nephropathy | 2 1|
Renal Tubule, Giant Cell, Focal | |
Renal Tubule, Mineralization, Focal | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Infiltration Cellular, Focal, | |
Lymphocyte | 1|
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 108
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 1| 9| 4| 4| 4| 4| 1| 4| 4| 4| 1| 4| 4| 4| 4| 3| 4| 4| 4| 4|
| 2| 2| 2| 2| 2| 6| 6| 3| 2| 3| 3| 1| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +|
Hyperplasia, Focal, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Prolapse | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Clear Cell Focus, Multifocal | |
Cyst, Focal | |
Cytoplasmic Alteration, Focal | |
Degeneration, Focal | |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation, | |
Focal | |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 |
Hemorrhage, Focal | |
Infarct, Focal | |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 |
Mixed Cell Focus | X |
Necrosis, Multifocal | |
Thrombosis, Multifocal | |
Hepatocyte, Cytomegaly, Focal | |
Sinusoid, Ectasia, Focal | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
_____________________________________________________________________________________________________________________|
Page 109
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 1| 9| 4| 4| 4| 4| 1| 4| 4| 4| 1| 4| 4| 4| 4| 3| 4| 4| 4| 4|
| 2| 2| 2| 2| 2| 6| 6| 3| 2| 3| 3| 1| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Lymphocyte | 2 |
Inflammation, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Multifocal | 2|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 2 2 2|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myocardium, Inflammation, Multifocal | 2 |
Valve, Pigmentation, Focal | 2 2 |
Valve, Pigmentation, Multifocal | 2 2|
Ventricle, Thrombosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia, Focal | 2 |
Capsule, Hyperplasia, Multifocal | 2 2 3 3 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular, Focal | 2 |
Giant Cell, Multifocal | 2 |
Hyperplasia, Focal | |
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Cyst, Focal | 2 |
Ectopic Tissue | |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + M + + M + + + + + + + + M M + + M +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Follicle, Dilatation, Focal | 2 |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 110
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 1| 9| 4| 4| 4| 4| 1| 4| 4| 4| 1| 4| 4| 4| 4| 3| 4| 4| 4| 4|
| 2| 2| 2| 2| 2| 6| 6| 3| 2| 3| 3| 1| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation, Focal | |
Spermatocele, Focal | 3 |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | |
Hyperplasia | |
Inflammation | |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + M + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Focal | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Mineralization, Focal | 2 1 |
Bilateral, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
Leukocytosis | 3 |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Focal | 3 |
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + M + + + + + + M + + M M + M M + + + + M M|
Giant Cell, Multifocal | |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + M + + + + + +|
Pigmentation | 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M + M M + + + + + + + M M + + M M + + M + +|
Hyperplasia, Lymphoid | 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + M + + + + M|
Erythrophagocytosis | 2 2 2 2 |
Giant Cell, Multifocal | 2 2 |
Hemorrhage | 3 2 2 2 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 2 4 4 3 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 111
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 1| 9| 4| 4| 4| 4| 1| 4| 4| 4| 1| 4| 4| 4| 4| 3| 4| 4| 4| 4|
| 2| 2| 2| 2| 2| 6| 6| 3| 2| 3| 3| 1| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + M + + + + + M + + + +|
Cyst | X |
Cyst, Multifocal | |
Ectopic Parathyroid Gland, Focal | X |
Epithelial Cell, Cytoplasmic | |
Alteration, Focal | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | |
Lymphatic, Dilatation | |
Subcutaneous Tissue, Angiectasis | |
Subcutaneous Tissue, Fibrosis, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization, Focal | 1 |
Mineralization, Multifocal | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + M + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 |
Infiltration Cellular, Histiocyte | |
Inflammation, Granulomatous | 2 2 2 4 |
Inflammation | 1 2 2 1 2 1 3 2 3 2 3 2|
Alveolar Epithelium, Hyperplasia | |
Glands, Inflammation | 1 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 2 2 2 3 3 4 2 3 3 2 3 2 2 3 2 4 2 2 4 3 3 3|
Olfactory Epithelium, Metaplasia | 2 3 2 2 3 3 3 2 2 3 3 2 3 3 2 2 2 2 2 3 3 4 2 3|
Respiratory Epithelium, Hyperplasia | 2 3 3 2 3 3 3 3 2 3 3 4 3 3 3 3 3 2 4 3 3 3 2 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 112
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 6| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 4| 4| 4| 1| 9| 4| 4| 4| 4| 1| 4| 4| 4| 1| 4| 4| 4| 4| 3| 4| 4| 4| 4|
| 2| 2| 2| 2| 2| 6| 6| 3| 2| 3| 3| 1| 3| 3| 3| 4| 3| 3| 3| 3| 1| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
30 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cornea, Inflammation, Focal | |
Iris, Hyperplasia, Multifocal, | |
Melanocyte | |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypoplasia | |
Infarct, Focal | 2 |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2|
Inflammation, Acute, Multifocal | 1 |
Nephropathy | 2 |
Renal Tubule, Giant Cell, Focal | 2 |
Renal Tubule, Mineralization, Focal | 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 2 2 2 2 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 113
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 0| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 9| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| |
| 4| 4| 4| 4| 4| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + +| 65 |
Hemorrhage, Focal | 2| 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + +| 65 |
Hyperplasia, Focal, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + +| 68 |
Parasite Metazoan | X X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + +| 66 |
Hemorrhage, Focal | 2| 1 2.0|
Prolapse | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + +| 66 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + +| 66 |
Hyperplasia, Focal, Lymphoid | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + +| 68 |
Clear Cell Focus | X | 2 |
Clear Cell Focus, Multifocal | X | 1 |
Cyst, Focal | 2 | 1 2.0|
Cytoplasmic Alteration, Focal | | 1 2.0|
Degeneration, Focal | | 1 3.0|
Eosinophilic Focus | | 1 |
Hematopoietic Cell Proliferation, | | |
Focal | | 2 1.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | | 1 2.0|
Hemorrhage, Focal | 2 | 1 2.0|
Infarct, Focal | | 1 4.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 2 1.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
Mixed Cell Focus | | 1 |
Necrosis, Multifocal | 3| 1 3.0|
Thrombosis, Multifocal | | 1 3.0|
Hepatocyte, Cytomegaly, Focal | 2 | 1 2.0|
Sinusoid, Ectasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 114
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 0| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 9| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| |
| 4| 4| 4| 4| 4| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + +| 68 |
Atrophy | | 4 3.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 3 1.3|
Inflammation, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + +| 68 |
Atrophy, Multifocal | | 1 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 4 1.8|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 2 2 2 2 2 1 | 16 1.8|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + +| 68 |
Hyperplasia, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + +| 68 |
Cyst, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + +| 68 |
Myocardium, Inflammation, Multifocal | | 1 2.0|
Valve, Pigmentation, Focal | 2 | 5 1.6|
Valve, Pigmentation, Multifocal | 2 | 3 2.0|
Ventricle, Thrombosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + +| 68 |
Capsule, Hyperplasia, Focal | | 2 2.0|
Capsule, Hyperplasia, Multifocal | 2 2 2 2 2 3 2 2 2 | 49 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + +| 68 |
Atypia Cellular, Focal | | 1 2.0|
Giant Cell, Multifocal | | 1 2.0|
Hyperplasia, Focal | 2 | 1 2.0|
Hypertrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + +| 66 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + +| 66 |
Cyst, Focal | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 115
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 0| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 9| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| |
| 4| 4| 4| 4| 4| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Ectopic Tissue | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + + + + + + + M +| 55 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +| 68 |
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 1 2.0|
Follicle, Dilatation, Focal | 3 | 3 2.3|
Follicular Cell, Hyperplasia, Focal | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + +| 68 |
Granuloma Sperm | | 1 3.0|
Inflammation, Focal | | 1 1.0|
Spermatocele, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | | 3 |
Hyperplasia | | 1 2.0|
Inflammation | | 1 3.0|
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | M + + + + + + + + + + + + + + + + +| 66 |
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + +| 68 |
Dilatation | | 1 3.0|
Inflammation, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + +| 68 |
Atrophy | | 2 2.0|
Mineralization, Focal | | 4 1.8|
Bilateral, Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
Leukocytosis | | 1 3.0|
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + +| 68 |
Congestion | | 1 2.0|
Hemorrhage, Focal | | 1 3.0|
Hyperplasia | | 5 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 116
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 0| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 9| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| |
| 4| 4| 4| 4| 4| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + + + + + M M M + + M M + +| 43 |
Giant Cell, Multifocal | 2 | 1 2.0|
Pigmentation | 1 | 3 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + +| 66 |
Pigmentation | 2 2 2 2 2 2 | 11 1.9|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M M M + + M + + M + + + + + M +| 47 |
Hyperplasia, Lymphoid | | 1 2.0|
Pigmentation | 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + +| 63 |
Erythrophagocytosis | 2 2 2 2 | 13 2.0|
Giant Cell, Multifocal | 1 2 2 2 2 2 2 | 16 1.9|
Hemorrhage | 2 2 2 4 2 | 13 2.3|
Hyperplasia, Lymphoid | 3 2 | 4 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + +| 68 |
Congestion | | 1 3.0|
Hematopoietic Cell Proliferation | 3 3| 13 2.9|
Hyperplasia, Lymphoid | 2 2 2 2 | 5 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + + + +| 63 |
Cyst | 2 | 2 2.0|
Cyst, Multifocal | 2 | 2 2.0|
Ectopic Parathyroid Gland, Focal | | 1 |
Epithelial Cell, Cytoplasmic | | |
Alteration, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M| |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + +| 68 |
Inflammation, Focal | 2 | 2 2.0|
Lymphatic, Dilatation | | 2 3.0|
Subcutaneous Tissue, Angiectasis | | 1 2.0|
Subcutaneous Tissue, Fibrosis, | | |
Multifocal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + +| 68 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + +| 68 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 117
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 0| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 9| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| |
| 4| 4| 4| 4| 4| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Mineralization, Focal | 1 1 | 4 1.0|
Mineralization, Multifocal | 1 1 2 2 2 | 25 1.9|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + +| 67 |
Inflammation, Focal | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + +| 68 |
Infiltration Cellular, Lymphocyte | 2 | 4 2.3|
Infiltration Cellular, Histiocyte | 2 1 | 5 1.6|
Inflammation, Granulomatous | 3 2 2 | 12 2.4|
Inflammation | 2 3 3 2 2 2 1 3 3 2 2| 28 2.1|
Alveolar Epithelium, Hyperplasia | 2 2 | 4 1.5|
Glands, Inflammation | 2 2 | 8 2.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + +| 68 |
Inflammation | 3 3 1 4 3 2 2 2 2 3 2 2 2 2 3 3 3 2| 67 2.6|
Olfactory Epithelium, Metaplasia | 2 3 2 3 3 2 2 3 2 4 2 2 2 3 3 3 2 2| 67 2.4|
Respiratory Epithelium, Hyperplasia | 3 4 2 3 3 2 2 3 2 3 3 2 2 3 3 3 2 3| 67 2.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + +| 67 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + | 3 |
Cornea, Inflammation, Focal | 3 | 1 3.0|
Iris, Hyperplasia, Multifocal, | | |
Melanocyte | 3 | 1 3.0|
Lens, Cataract | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + +| 68 |
Hypoplasia | | 1 3.0|
Infarct, Focal | | 2 2.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 3 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 2 2 2 2 2 2 2| 18 1.9|
Inflammation, Acute, Multifocal | | 1 1.0|
Nephropathy | 2 2 2 | 6 1.8|
Renal Tubule, Giant Cell, Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 118
NTP Experiment-Test: 05110-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NAPHTHALENE Date: 04/28/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:51:23
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 7| 0| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 1| 1| 1| 1| 1| 4| 9| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| |
| 4| 4| 4| 4| 4| 3| 1| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| A |
30 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Mineralization, Focal | | 3 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + +| 68 |
Dilatation | | 2 3.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | 2 | 2 1.5|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 1 1 2| 7 1.7|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 119
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---------- END OF REPORT ----------
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