TDMS Study 05110-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Northrop Services DATE: 09/14/94
EXP: 05110 NAPHTHALENE TIME: 02:28:35
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 52904B
CONT: NO1ES790009 CAS: 91-20-3
PATHOLOGIST: L. BRENNECKE
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
ALL
TREATMENT GROUPS:
INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Northrop Services DATE: 09/14/94
EXP: 05110 NAPHTHALENE TIME: 02:28:35
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 52904B
CONT: NO1ES790009 CAS: 91-20-3
PATHOLOGIST: L. BRENNECKE
NAPHTHALENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 75 UNCENSORED DEATHS 44 CENSORED DEATHS 5 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 15 48 48 83 83 83 83 84 88 112 |
| 134 158 183 196 235 255 282 320 326 327 |
| 361 382 383 389 396 421 465 558 589 590 |
| 620 652 654 655 681 688 697 700 704 706 |
| 706 714 715 725 |
| CENSORED DEATHS |
| 14 14 14 14 14 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM |
| --------------------- |
| |
| TOTAL 75 UNCENSORED DEATHS 17 CENSORED DEATHS 6 TERMINAL 52 |
| |
| UNCENSORED DEATHS |
| 14 30 31 119 265 287 303 330 372 536 |
| 629 640 659 680 690 692 693 |
| CENSORED DEATHS |
| 14 14 14 14 14 147 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 PPM |
| --------------------- |
| |
| TOTAL 75 UNCENSORED DEATHS 5 CENSORED DEATHS 10 TERMINAL 60 |
| |
| UNCENSORED DEATHS |
| 280 302 504 578 644 |
| CENSORED DEATHS |
| 14 14 14 14 14 91 182 182 196 547 |
| |
==================================================================================
NAPHTHALENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 30 PPM |
| --------------------- |
| |
| TOTAL 75 UNCENSORED DEATHS 10 CENSORED DEATHS 7 TERMINAL 58 |
| |
| UNCENSORED DEATHS |
| 14 493 611 616 631 656 672 696 700 702 |
| CENSORED DEATHS |
| 14 14 14 14 14 91 91 |
| |
==================================================================================
NAPHTHALENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 736 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 87.1 82.9 77.1 70.0 62.9 61.4 61.4 57.1 51.4 37.1 |
| | |
| | |
|10 PPM | 95.8 94.4 92.9 88.6 87.1 87.1 85.7 85.7 81.3 75.5 |
| | |
| | |
|30 PPM | 100.0 100.0 100.0 97.0 97.0 97.0 95.5 93.9 92.4 92.4 |
| | |
| | |
|30 PPM | 98.7 98.7 98.7 98.7 98.7 98.7 97.2 97.2 91.3 85.4 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 10 PPM 30 PPM 30 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 37.1% 75.5% 92.4% 85.4% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P<0.001 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 393.0 410.0 461.6 579.1 |
|NATURAL DEATHS (C) | (37.4) (62.9) (73.2) (65.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 486.7 606.1 636.5 649.7 |
|(STANDARD ERROR) | (32.2) (28.7) (25.8) (25.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NAPHTHALENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 75 UNCENSORED DEATHS 10 CENSORED DEATHS 6 TERMINAL 59 |
| |
| UNCENSORED DEATHS |
| 140 140 183 574 590 644 655 662 678 729 |
| CENSORED DEATHS |
| 14 14 14 14 14 561 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 PPM |
| --------------------- |
| |
| TOTAL 75 UNCENSORED DEATHS 7 CENSORED DEATHS 11 TERMINAL 57 |
| |
| UNCENSORED DEATHS |
| 183 197 287 548 669 716 718 |
| CENSORED DEATHS |
| 14 14 14 14 14 91 91 127 127 463 |
| 586 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 30 PPM |
| --------------------- |
| |
| TOTAL 75 UNCENSORED DEATHS 16 CENSORED DEATHS 7 TERMINAL 52 |
| |
| UNCENSORED DEATHS |
| 67 351 366 427 466 614 626 648 663 677 |
| 688 696 711 713 714 722 |
| CENSORED DEATHS |
| 14 14 14 14 14 91 234 |
| |
==================================================================================
NAPHTHALENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 30 PPM |
| --------------------- |
| |
| TOTAL 75 UNCENSORED DEATHS 17 CENSORED DEATHS 8 TERMINAL 50 |
| |
| UNCENSORED DEATHS |
| 423 471 611 623 625 627 648 658 659 660 |
| 668 689 696 702 708 721 731 |
| CENSORED DEATHS |
| 14 14 14 14 14 91 156 215 |
| |
==================================================================================
NAPHTHALENE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 736 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 97.1 95.7 95.7 95.7 95.7 95.7 92.8 88.5 85.6 |
| | |
| | |
|10 PPM | 100.0 100.0 97.0 95.5 95.5 95.5 95.5 93.9 93.9 89.2 |
| | |
| | |
|30 PPM | 98.6 98.6 98.6 97.1 95.6 92.7 92.7 92.7 86.8 76.5 |
| | |
| | |
|30 PPM | 100.0 100.0 100.0 100.0 98.5 97.0 97.0 97.0 85.1 74.6 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 10 PPM 30 PPM 30 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 85.6% 89.2% 76.5% 74.6% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.042 P=0.697N P=0.274 P=0.195 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 499.5 474.0 571.8 642.4 |
|NATURAL DEATHS (C) | (76.6) (92.3) (46.5) (19.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 654.0 624.3 637.5 643.4 |
|(STANDARD ERROR) | (24.1) (27.4) (25.1) (24.2) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NAPHTHALENE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
10 PPM = 2
30 PPM = 3
30 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 21 3
| 21 2 1 3 3 43 4
| 2 1 1 2 2 3 3 4 43
| 2 2 2 43 4 4 3
90 + 2 2 4 4
| 11 1 2 2 2 44
P | 1 1 1 2 2 2 4 4
E | 1 11 2 2 2
R 80 + 1 1 22
C | 1 1 1
E | 1 11 2 2
N | 1 1
T 70 + 1 1
| 11
S | 11 1
U | 1 1 1
R 60 + 1 1
V | 1 1
I | 1 1
V | 1 1
A 50 + 11
L | 11
| 11
| 11
40 + 11
| 11 1
|
|
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 22 obs hidden.
NAPHTHALENE
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
10 PPM = 2
30 PPM = 3
30 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 2 4
| 3 2 2 3 4 4
| 1 1 2 2 3 3 4 4
| 1 3 3 1
P 95 + 2 2 44
E | 3 3 2 1 1 44 2
R | 3 1 3 1 2 2
C | 3 3 141
E 90 + 3 31 1
N | 3 1 1 2 2
T | 4 4 1 1
| 3 3
S 85 + 443 3 11
U | 4 33
R | 43 3
V |
I 80 + 44
V | 44
A | 343
L | 43 43
75 + 44
|
|
|
70 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 10 obs hidden.