TDMS Study 05111-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
1,2,3-TRICHLOROPROPANE
NTP Experiment-Test: 05111-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/14/94
Route: GAVAGE Time: 08:34:18
Facility: TSI Mason Research
Chemical CAS #: 96-18-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05111-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 09/14/94
Route: GAVAGE Time: 08:34:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 9 6
Early Deaths
Moribund 8 34 37 48
Dead 1 3 4 1
Accident 1
Survivors
Terminal Sacrifice 41 13
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (60) (60) (59)
Hyperkeratosis 1 (2%)
Inflammation, Acute 1 (2%)
Liver (60) (60) (60) (60)
Basophilic Focus 1 (2%) 4 (7%) 1 (2%)
Clear Cell Focus 1 (2%) 1 (2%) 1 (2%)
Cyst 1 (2%) 1 (2%)
Eosinophilic Focus 7 (12%) 10 (17%) 38 (63%)
Eosinophilic Focus, Multiple 1 (2%)
Fatty Change, Diffuse 1 (2%) 1 (2%)
Fatty Change, Focal 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Granuloma 1 (2%)
Hematopoietic Cell Proliferation 4 (7%)
Mixed Cell Focus 3 (5%) 1 (2%) 2 (3%) 2 (3%)
Necrosis 1 (2%) 6 (10%) 5 (8%) 10 (17%)
Thrombosis 1 (2%)
Mesentery (3) (17) (20) (10)
Fat, Necrosis 2 (67%) 1 (6%)
Pancreas (59) (60) (60) (60)
Cyst 1 (2%)
Acinus, Hyperplasia 1 (2%) 2 (3%)
Duct, Ectasia 1 (2%)
Stomach, Forestomach (60) (59) (60) (60)
Hyperkeratosis 5 (8%) 25 (42%) 23 (38%) 38 (63%)
Hyperplasia, Basal Cell 1 (2%)
Hyperplasia, Squamous 11 (18%) 25 (42%) 23 (38%) 36 (60%)
Necrosis 1 (2%) 2 (3%)
Ulcer 2 (3%) 1 (2%)
Stomach, Glandular (59) (60) (59) (59)
Hyperplasia 1 (2%) 4 (7%) 2 (3%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05111-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 09/14/94
Route: GAVAGE Time: 08:34:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Acute 1 (2%)
Tongue (1) (3) (1)
Acanthosis 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Cardiomyopathy 1 (2%)
Mineralization 1 (2%) 2 (3%)
Thrombosis 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (60) (57) (59) (59)
Accessory Adrenal Cortical Nodule 1 (2%)
Adrenal Gland, Cortex (60) (57) (58) (59)
Accessory Adrenal Cortical Nodule 1 (2%) 1 (2%)
Adrenal Gland, Medulla (59) (54) (56) (59)
Hyperplasia 1 (2%)
Pituitary Gland (58) (56) (54) (58)
Pars Distalis, Angiectasis 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 12 (21%) 7 (13%) 2 (4%) 1 (2%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (59) (58) (58) (59)
Follicular Cell, Hyperplasia 8 (14%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (3) (5) (6) (8)
Dilatation 2 (67%) 3 (60%) 5 (83%) 7 (88%)
Ovary (59) (59) (57) (58)
Abscess 1 (2%) 1 (2%)
Angiectasis 1 (2%)
Cyst 10 (17%) 9 (15%) 6 (11%) 9 (16%)
Degeneration, Cystic 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 2 (3%) 1 (2%)
Thrombosis 1 (2%)
Uterus (60) (60) (60) (59)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05111-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 09/14/94
Route: GAVAGE Time: 08:34:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Abscess 1 (2%)
Cyst 3 (5%)
Dilatation 6 (10%) 6 (10%) 1 (2%)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Endometrium, Hyperplasia 43 (72%) 41 (68%) 44 (73%) 57 (97%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (60) (59) (60) (60)
Lumbar, Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Mediastinal, Hematopoietic Cell Proliferation 1 (2%)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 (2%) 2 (3%) 1 (2%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (2%) 2 (3%)
Pancreatic, Infiltration Cellular, Plasma
Cell 1 (2%)
Renal, Inflammation, Granulomatous 1 (2%)
Lymph Node, Mandibular (56) (57) (57) (57)
Hematopoietic Cell Proliferation 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Lymph Node, Mesenteric (58) (55) (59) (58)
Angiectasis 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Inflammation, Granulomatous 1 (2%)
Thrombosis 1 (2%)
Spleen (59) (60) (60) (58)
Hematopoietic Cell Proliferation 8 (14%) 36 (60%) 45 (75%) 47 (81%)
Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (60) (60) (60)
Erosion 2 (3%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05111-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 09/14/94
Route: GAVAGE Time: 08:34:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Hemorrhage 3 (5%) 4 (7%) 2 (3%)
Infiltration Cellular, Histiocyte 2 (3%) 3 (5%) 1 (2%)
Inflammation, Acute 3 (5%) 6 (10%)
Leukocytosis 1 (2%) 2 (3%)
Alveolar Epithelium, Hyperplasia 2 (3%) 1 (2%)
Bronchiole, Hyperplasia 3 (5%) 43 (72%)
Nose (60) (59) (60) (60)
Inflammation, Acute 1 (2%) 1 (2%) 5 (8%) 2 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3) (7) (8) (10)
Hyperplasia 1 (13%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (60) (60) (60)
Nephropathy 1 (2%) 2 (3%) 1 (2%)
Cortex, Mineralization 1 (2%) 1 (2%)
Papilla, Mineralization 1 (2%)
Renal Tubule, Pigmentation 2 (3%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05111-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 09/14/94
Route: GAVAGE Time: 08:34:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 9
Early Deaths
Dead 7 7 4 3
Moribund 3 26 40 44
Survivors
Terminal Sacrifice 42 18
Wrong Sex 1
Animals Examined Microscopically 60 59 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (55) (58) (60) (58)
Hyperkeratosis 2 (3%)
Hyperplasia, Basal Cell 1 (2%)
Gallbladder (55) (54) (57) (59)
Dilatation 1 (2%)
Hyperplasia 1 (2%)
Intestine Large, Cecum (59) (57) (59) (59)
Hyperplasia 1 (2%)
Liver (60) (59) (60) (60)
Basophilic Focus 7 (12%) 3 (5%) 5 (8%)
Clear Cell Focus 1 (2%) 1 (2%)
Cyst 1 (2%) 1 (2%)
Eosinophilic Focus 2 (3%) 3 (5%) 9 (15%) 34 (57%)
Fatty Change, Diffuse 1 (2%)
Fatty Change, Focal 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Inflammation, Acute 1 (2%)
Mixed Cell Focus 2 (3%) 2 (3%)
Necrosis 2 (3%) 3 (5%) 14 (23%) 8 (13%)
Mesentery (4) (15) (17) (16)
Hemorrhage 1 (25%)
Fat, Mineralization 2 (12%)
Fat, Necrosis 1 (25%) 1 (7%)
Pancreas (60) (58) (59) (59)
Acinus, Hyperplasia 2 (3%) 1 (2%)
Stomach, Forestomach (60) (59) (60) (60)
Hyperkeratosis 3 (5%) 35 (59%) 32 (53%) 44 (73%)
Hyperplasia, Basal Cell 2 (3%) 2 (3%)
Hyperplasia, Squamous 8 (13%) 37 (63%) 32 (53%) 38 (63%)
Inflammation, Acute 1 (2%)
Ulcer 5 (8%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05111-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 09/14/94
Route: GAVAGE Time: 08:34:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Glandular (60) (58) (59) (60)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Tongue (2) (1) (1) (3)
Mineralization 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (59) (60) (60)
Embolus 1 (2%)
Mineralization 1 (2%) 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (59) (57) (58)
Accessory Adrenal Cortical Nodule 1 (2%)
Hypertrophy 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Islets, Pancreatic (60) (58) (59) (59)
Hyperplasia 1 (2%)
Thyroid Gland (57) (59) (60) (60)
Follicular Cell, Hyperplasia 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (35) (44) (42) (43)
Abscess 1 (2%)
Dilatation 30 (86%) 39 (89%) 35 (83%) 28 (65%)
Prostate (59) (58) (60) (57)
Hyperplasia 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (60) (59) (60) (60)
Bronchial, Infiltration Cellular, Plasma Cell 1 (2%)
Bronchial, Infiltration Cellular, Histiocyte 1 (2%)
Iliac, Infiltration Cellular, Plasma Cell 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05111-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 09/14/94
Route: GAVAGE Time: 08:34:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Hematopoietic Cell Proliferation 2 (3%) 2 (3%) 1 (2%)
Mediastinal, Infiltration Cellular, Plasma
Cell 2 (3%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (2%) 2 (3%)
Lymph Node, Mandibular (56) (55) (57) (53)
Infiltration Cellular, Plasma Cell 1 (2%)
Lymph Node, Mesenteric (56) (56) (58) (58)
Angiectasis 5 (9%) 9 (16%) 4 (7%) 4 (7%)
Hematopoietic Cell Proliferation 8 (14%) 8 (14%) 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Necrosis 1 (2%)
Thrombosis 1 (2%)
Spleen (60) (59) (60) (60)
Angiectasis 1 (2%)
Depletion Lymphoid 1 (2%)
Hematopoietic Cell Proliferation 4 (7%) 36 (61%) 46 (77%) 44 (73%)
Hemorrhage 1 (2%)
Thymus (54) (47) (53) (49)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (57) (60) (59)
Erosion 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (58) (60) (60)
Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (59) (60) (60)
Edema 1 (2%) 1 (2%)
Embolus Tumor 1 (2%)
Hemorrhage 3 (5%) 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Infiltration Cellular, Histiocyte 2 (3%) 2 (3%) 2 (3%) 4 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05111-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 09/14/94
Route: GAVAGE Time: 08:34:18
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Acute 1 (2%) 3 (5%) 2 (3%)
Leukocytosis 3 (5%) 5 (8%) 2 (3%)
Alveolar Epithelium, Hyperplasia 1 (2%) 5 (8%) 2 (3%)
Bronchiole, Hyperplasia 1 (2%) 3 (5%) 31 (52%)
Nose (60) (59) (60) (60)
Inflammation, Acute 1 (2%) 4 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (2) (3)
Cornea, Inflammation, Acute 1 (50%)
Cornea, Necrosis 1 (50%)
Harderian Gland (1) (3) (11) (13)
Hyperplasia 1 (9%) 1 (8%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (59) (60) (60)
Cyst 1 (2%)
Nephropathy 4 (7%) 3 (5%)
Renal Tubule, Regeneration 1 (2%)
Urinary Bladder (59) (58) (59) (59)
Calculus Gross Observation 1 (2%) 2 (3%)
Calculus Micro Observation Only 1 (2%) 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
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