TDMS Study 05111-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 1,2,3-TRICHLOROPROPANE DATE: 09/14/94
EXPERIMENT: 05111 TEST: 02 TIME: 08:56:33
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-45048 ROUTE: GAVAGE NTP C#: C60220
PATHOLOGIST: K. MURTHY CAS: 96-18-4
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 1,2,3-TRICHLOROPROPANE DATE: 09/14/94
EXPERIMENT: 05111 TEST: 02 TIME: 08:56:33
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-45048 ROUTE: GAVAGE NTP C#: C60220
PATHOLOGIST: K. MURTHY CAS: 96-18-4
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 1,2,3-TRICHLOROPROPANE DATE: 09/14/94
EXPERIMENT: 05111 TEST: 02 TIME: 08:56:33
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-45048 ROUTE: GAVAGE NTP C#: C60220
PATHOLOGIST: K. MURTHY CAS: 96-18-4
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 1,2,3-TRICHLOROPROPANE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Harderian Gland Adenoma
Liver Hemangiosarcoma
Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip)
Papilloma Squamous or Papilloma
Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
Stomach, Forestomach Squamous Cell Carcinoma
Squamous Cell Carcinoma or Papilloma Squamous
Squamous Cell Papilloma
Tongue Squamous Cell Papilloma
All Organs Hemangiosarcoma
Hemangiosarcoma or Hemangioma
Malignant Lymphoma And Histiocytic Sarcoma
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 1,2,3-TRICHLOROPROPANE DATE: 09/14/94
EXPERIMENT: 05111 TEST: 02 TIME: 08:56:33
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-45048 ROUTE: GAVAGE NTP C#: C60220
PATHOLOGIST: K. MURTHY CAS: 96-18-4
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 1,2,3-TRICHLOROPROPANE
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Harderian Gland Adenoma
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Mammary Gland Adenoacanthoma
Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip)
Squamous Cell Carcinoma
Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
Pharynx Squamous Cell Carcinoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Skin: Subcutaneous Tissue Sarcoma
Stomach, Forestomach Squamous Cell Carcinoma
Squamous Cell Carcinoma or Papilloma Squamous
Squamous Cell Papilloma
Uterus Adenoma
Carcinoma
Polyp Stromal
All Organs Hemangiosarcoma or Hemangioma
Histiocytic Sarcoma
Malignant Lymphoma And Histiocytic Sarcoma
Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
NOS, or Undifferentiated Cell Type
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2,3-TRICHLOROPROPANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/59 (3%) 10/60 (17%) 11/60 (18%) | 3/60 (5%) 6/60 (10%) 7/60 (12%) 10/60 (17%) |
|ADJUSTED (b) | 2.4% 6.5% 44.3% 49.2% | 6.5% 26.8% 39.0% 57.2% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 0/6 (0%) 0/4 (0%) | 1/10 (10%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 1/6 (17%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 2/9 (22%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 2/10 (20%) 0/0 | 0/0 0/0 2/9 (22%) 0/0 |
|TERMINAL (d) | 1/42 (2%) 0/18 (0%) 0/0 0/0 | 2/41 (5%) 2/13 (15%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 639 505 452 | 461 (I) 558 545 445 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.323 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.036 * P=0.013 * P<0.001 ** |
|INCIDENTAL TUMOR | P=0.016 * P=0.765N P=0.282 P=0.143 | P=0.031 * P=0.294 P=0.700N P=0.642 |
|LOGISTIC REGRESSION | P=0.005 ** P=0.449 P=0.002 ** P=0.008 ** | P=0.002 ** P=0.191 P=0.579N P=0.250 |
|COCHRAN-ARMITAGE | P=0.001 ** | P=0.040 * |
|FISHER EXACT | P=0.494 P=0.004 ** P=0.002 ** | P=0.245 P=0.161 P=0.037 * |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 0/59 (0%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 6.6% 0.0% 0.0% 0.0% | 0.0% 0.0% 7.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 0/6 (0%) 0/4 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 0/10 (0%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 1/42 (2%) 0/18 (0%) 0/0 0/0 | 0/41 (0%) 0/13 (0%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 533 --- --- --- | --- --- 603 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.515N P=0.196N P=0.433N P=0.740N | P=0.771 (e) P=0.250 (e) |
|INCIDENTAL TUMOR | P=0.093N P=0.039N* P=0.005N** P=0.096N | P=0.950 (e) P=0.965 (e) |
|LOGISTIC REGRESSION | P=0.175N P=0.118N P=0.122N P=0.162N | P=0.851 (e) P=0.468 (e) |
|COCHRAN-ARMITAGE | P=0.134N | P=0.786N |
|FISHER EXACT | P=0.125N P=0.122N P=0.122N | (e) P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2,3-TRICHLOROPROPANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/60 (20%) 18/59 (31%) 21/60 (35%) 31/60 (52%) | 7/60 (12%) 9/60 (15%) 9/60 (15%) 36/60 (60%) |
|ADJUSTED (b) | 25.1% 61.9% 72.2% 100.0% | 16.1% 47.7% 65.0% 97.1% |
|INTERIM SACRIFICE 1 (c)| 1/8 (13%) 0/8 (0%) 0/6 (0%) 2/4 (50%) | 1/10 (10%) 0/10 (0%) 1/9 (11%) 5/5 (100%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 5/6 (83%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 9/9 (100%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 4/10 (40%) 0/0 | 0/0 0/0 6/9 (67%) 0/0 |
|TERMINAL (d) | 7/42 (17%) 9/18 (50%) 0/0 0/0 | 6/41 (15%) 5/13 (38%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 457 (I) 520 410 322 | 461 (I) 540 454 420 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.003 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.011 * P=0.173 P<0.001 ** |
|INCIDENTAL TUMOR | P=0.009 ** P=0.233 P=0.628 P=0.052 | P<0.001 ** P=0.071 P=0.637 P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.073 P=0.028 * P=0.007 ** | P<0.001 ** P=0.164 P=0.057 P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.134 P=0.051 P<0.001 ** | P=0.395 P=0.395 P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 11/59 (19%) 6/60 (10%) 3/60 (5%) | 1/60 (2%) 3/60 (5%) 0/60 (0%) 2/60 (3%) |
|ADJUSTED (b) | 9.2% 40.6% 32.4% 15.6% | 2.4% 13.2% 0.0% 14.4% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 1/6 (17%) 0/4 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 1/9 (11%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 2/10 (20%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 3/42 (7%) 4/18 (22%) 0/0 0/0 | 1/41 (2%) 1/13 (8%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 592 577 457 (I) 389 | 733 (T) 582 --- 494 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.004 ** P=0.002 ** P=0.034 * P=0.182 | P<0.001 ** P=0.100 (e) P=0.036 * |
|INCIDENTAL TUMOR | P=0.456 P=0.137 P=0.718 P=0.721N | P=0.418 P=0.430 (e) P=0.874 |
|LOGISTIC REGRESSION | P=0.533 P=0.015 * P=0.194 P=0.666 | P=0.259 P=0.242 (e) P=0.395 |
|COCHRAN-ARMITAGE | P=0.113N | P=0.577 |
|FISHER EXACT | P=0.044 * P=0.372 P=0.500N | P=0.309 P=0.500N P=0.500 |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2,3-TRICHLOROPROPANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/60 (23%) 24/59 (41%) 25/60 (42%) 33/60 (55%) | 8/60 (13%) 11/60 (18%) 9/60 (15%) 36/60 (60%) |
|ADJUSTED (b) | 29.3% 72.8% 82.9% 100.0% | 18.5% 55.8% 65.0% 97.1% |
|INTERIM SACRIFICE 1 (c)| 1/8 (13%) 0/8 (0%) 1/6 (17%) 2/4 (50%) | 1/10 (10%) 0/10 (0%) 1/9 (11%) 5/5 (100%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 5/6 (83%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 9/9 (100%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 6/10 (60%) 0/0 | 0/0 0/0 6/9 (67%) 0/0 |
|TERMINAL (d) | 9/42 (21%) 10/18 (56%) 0/0 0/0 | 7/41 (17%) 6/13 (46%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 457 (I) 520 410 322 | 461 (I) 540 454 420 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.003 ** P=0.173 P<0.001 ** |
|INCIDENTAL TUMOR | P=0.002 ** P=0.130 P=0.425 P=0.040 * | P<0.001 ** P=0.041 * P=0.637 P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.079 P=0.007 ** P=0.003 ** | P<0.001 ** P=0.093 P=0.067 P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.033 * P=0.025 * P<0.001 ** | P=0.309 P=0.500 P<0.001 ** |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/60 (23%) 24/59 (41%) 25/60 (42%) 33/60 (55%) | 8/60 (13%) 11/60 (18%) 9/60 (15%) 36/60 (60%) |
|ADJUSTED (b) | 29.3% 72.8% 82.9% 100.0% | 18.5% 55.8% 65.0% 97.1% |
|INTERIM SACRIFICE 1 (c)| 1/8 (13%) 0/8 (0%) 1/6 (17%) 2/4 (50%) | 1/10 (10%) 0/10 (0%) 1/9 (11%) 5/5 (100%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 5/6 (83%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 9/9 (100%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 6/10 (60%) 0/0 | 0/0 0/0 6/9 (67%) 0/0 |
|TERMINAL (d) | 9/42 (21%) 10/18 (56%) 0/0 0/0 | 7/41 (17%) 6/13 (46%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 457 (I) 520 410 322 | 461 (I) 540 454 420 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.003 ** P=0.173 P<0.001 ** |
|INCIDENTAL TUMOR | P=0.002 ** P=0.130 P=0.425 P=0.040 * | P<0.001 ** P=0.041 * P=0.637 P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.079 P=0.007 ** P=0.003 ** | P<0.001 ** P=0.093 P=0.067 P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.033 * P=0.025 * P<0.001 ** | P=0.309 P=0.500 P<0.001 ** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2,3-TRICHLOROPROPANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/60 (12%) 12/59 (20%) 3/60 (5%) 9/60 (15%) | 4/60 (7%) 3/60 (5%) 0/60 (0%) 11/60 (18%) |
|ADJUSTED (b) | 15.9% 37.7% 10.4% 34.0% | 9.4% 17.5% 0.0% 43.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 1/8 (13%) 0/6 (0%) 3/4 (75%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 1/5 (20%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 1/9 (11%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 0/10 (0%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 6/42 (14%) 4/18 (22%) 0/0 0/0 | 3/41 (7%) 2/13 (15%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 458 424 388 435 | 699 574 --- 379 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.013 * P=0.196 P<0.001 ** | P<0.001 ** P=0.314 (e) P<0.001 ** |
|INCIDENTAL TUMOR | P=0.225 P=0.158 P=0.543N P=0.137 | P=0.002 ** P=0.651 (e) P=0.177 |
|LOGISTIC REGRESSION | P=0.354 P=0.127 P=0.315N P=0.280 | P<0.001 ** P=0.585 P=0.939N P=0.054 |
|COCHRAN-ARMITAGE | P=0.555 | P=0.002 ** |
|FISHER EXACT | P=0.149 P=0.161N P=0.395 | P=0.500N P=0.059N P=0.048 * |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/59 (0%) 2/60 (3%) 0/60 (0%) | 3/60 (5%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 2.4% 0.0% 14.1% 0.0% | 6.9% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 0/6 (0%) 0/4 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 0/10 (0%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 1/42 (2%) 0/18 (0%) 0/0 0/0 | 2/41 (5%) 0/13 (0%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 590 --- | 631 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.221 P=0.669N P=0.045 * (e) | P=0.999N P=0.324N (e) (e) |
|INCIDENTAL TUMOR | P=0.756 P=0.669N P=0.754 (e) | P=0.747N P=0.072N P=0.035N* (e) |
|LOGISTIC REGRESSION | P=0.761 P=0.669N P=0.234 P=0.280 | P=0.645N P=0.181N P=0.502N P=0.794N |
|COCHRAN-ARMITAGE | P=0.454N | P=0.135N |
|FISHER EXACT | P=0.504N P=0.500 P=0.500N | P=0.122N P=0.122N P=0.122N |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2,3-TRICHLOROPROPANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/60 (13%) 12/59 (20%) 5/60 (8%) 9/60 (15%) | 7/60 (12%) 3/60 (5%) 0/60 (0%) 11/60 (18%) |
|ADJUSTED (b) | 18.2% 37.7% 23.1% 34.0% | 16.1% 17.5% 0.0% 43.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 1/8 (13%) 0/6 (0%) 3/4 (75%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 1/5 (20%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 1/9 (11%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 0/10 (0%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 7/42 (17%) 4/18 (22%) 0/0 0/0 | 5/41 (12%) 2/13 (15%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 458 424 388 435 | 631 574 --- 379 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.021 * P=0.020 * P<0.001 ** | P<0.001 ** P=0.588 (e) P<0.001 ** |
|INCIDENTAL TUMOR | P=0.196 P=0.207 P=0.641N P=0.137 | P=0.004 ** P=0.241N P=0.035N* P=0.177 |
|LOGISTIC REGRESSION | P=0.347 P=0.182 P=0.616N P=0.300 | P<0.001 ** P=0.363N P=0.305N P=0.103 |
|COCHRAN-ARMITAGE | P=0.496N | P=0.022 * |
|FISHER EXACT | P=0.219 P=0.279N P=0.500 | P=0.161N P=0.006N** P=0.222 |
|=================================================================================================================================|
| |
|Mammary Gland |
| Adenoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/59 (0%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 3/60 (5%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 2.7% 20.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 0/6 (0%) 0/4 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 1/6 (17%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 0/10 (0%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 0/42 (0%) 0/18 (0%) 0/0 0/0 | 0/41 (0%) 0/13 (0%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- --- 494 341 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.034 * (e) P=0.452 P=0.203 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.390 (e) P=0.898 P=0.580 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.073 (e) P=0.594 P=0.283 |
|COCHRAN-ARMITAGE | (e) | P=0.021 * |
|FISHER EXACT | (e) (e) (e) | (e) P=0.500 P=0.122 |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2,3-TRICHLOROPROPANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/59 (0%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 2/60 (3%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 6.6% 0.0% 2.9% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 0/6 (0%) 0/4 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 1/5 (20%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 0/10 (0%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 0/42 (0%) 0/18 (0%) 0/0 0/0 | 0/41 (0%) 0/13 (0%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 583 --- 461 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.087 P=0.156 (e) P=0.362 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.176 P=0.660 (e) P=0.362 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.622 P=0.242 (e) P=0.643 |
|COCHRAN-ARMITAGE | (e) | P=0.622 |
|FISHER EXACT | (e) (e) (e) | P=0.248 (e) P=0.500 |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Papilloma Squamous or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/59 (0%) 0/60 (0%) 2/60 (3%) | 1/60 (2%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 14.2% | 2.4% 0.0% 5.9% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 0/6 (0%) 0/4 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 1/9 (11%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 0/10 (0%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 0/42 (0%) 0/18 (0%) 0/0 0/0 | 1/41 (2%) 0/13 (0%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- 470 | 733 (T) --- 578 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.137 (e) (e) P=0.395 | P=0.829 P=0.728N P=0.302 (e) |
|INCIDENTAL TUMOR | P=0.467 (e) (e) P=0.906 | P=0.959 P=0.728N P=0.965 (e) |
|LOGISTIC REGRESSION | P=0.075 (e) (e) P=0.311 | P=0.881N P=0.728N P=0.629 (e) |
|COCHRAN-ARMITAGE | P=0.042 * | P=0.464N |
|FISHER EXACT | (e) (e) P=0.248 | P=0.500N P=0.752N P=0.500N |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2,3-TRICHLOROPROPANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/59 (0%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 5/60 (8%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 4.2% 16.3% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 0/6 (0%) 0/4 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 0/10 (0%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 0/42 (0%) 0/18 (0%) 0/0 0/0 | 0/41 (0%) 0/13 (0%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- --- 551 427 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P<0.001 ** (e) P=0.370 P=0.006 ** |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.056 (e) P=0.965 P=0.653 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.008 ** (e) P=0.552 P=0.128 |
|COCHRAN-ARMITAGE | (e) | P=0.001 ** |
|FISHER EXACT | (e) (e) (e) | (e) P=0.500 P=0.029 * |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/59 (0%) 0/60 (0%) 2/60 (3%) | 1/60 (2%) 0/60 (0%) 2/60 (3%) 5/60 (8%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 14.2% | 2.4% 0.0% 9.8% 16.3% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 0/6 (0%) 0/4 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 1/9 (11%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 0/10 (0%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 0/42 (0%) 0/18 (0%) 0/0 0/0 | 1/41 (2%) 0/13 (0%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- 470 | 733 (T) --- 551 427 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.137 (e) (e) P=0.395 | P<0.001 ** P=0.728N P=0.086 P=0.006 ** |
|INCIDENTAL TUMOR | P=0.467 (e) (e) P=0.906 | P=0.044 * P=0.728N P=0.872 P=0.653 |
|LOGISTIC REGRESSION | P=0.075 (e) (e) P=0.311 | P=0.024 * P=0.728N P=0.365 P=0.212 |
|COCHRAN-ARMITAGE | P=0.042 * | P=0.011 * |
|FISHER EXACT | (e) (e) P=0.248 | P=0.500N P=0.500 P=0.103 |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2,3-TRICHLOROPROPANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Pharynx |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/59 (0%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 5/60 (8%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 4.2% 16.3% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 0/6 (0%) 0/4 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 0/10 (0%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 0/42 (0%) 0/18 (0%) 0/0 0/0 | 0/41 (0%) 0/13 (0%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- --- 551 427 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P<0.001 ** (e) P=0.370 P=0.006 ** |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.056 (e) P=0.965 P=0.653 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.008 ** (e) P=0.552 P=0.128 |
|COCHRAN-ARMITAGE | (e) | P=0.001 ** |
|FISHER EXACT | (e) (e) (e) | (e) P=0.500 P=0.029 * |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/54 (0%) 0/56 (0%) 0/56 (0%) 0/58 (0%) | 4/58 (7%) 2/56 (4%) 0/54 (0%) 0/58 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 9.1% 14.1% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 0/6 (0%) 0/4 (0%) | 1/10 (10%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 0/10 (0%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 0/37 (0%) 0/18 (0%) 0/0 0/0 | 3/41 (7%) 1/12 (8%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 463 (I) 719 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.669N P=0.568 P=0.521N P=0.638N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.618N P=0.629N P=0.521N P=0.638N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.339N P=0.480N P=0.135N P=0.218N |
|COCHRAN-ARMITAGE | (e) | P=0.043N* |
|FISHER EXACT | (e) (e) (e) | P=0.356N P=0.068N P=0.059N |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2,3-TRICHLOROPROPANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/59 (2%) 0/60 (0%) 0/60 (0%) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 5.6% 0.0% 0.0% | 4.6% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 0/6 (0%) 0/4 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 0/10 (0%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 0/42 (0%) 1/18 (6%) 0/0 0/0 | 0/41 (0%) 0/13 (0%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- 729 (T) --- --- | 699 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=1.000 P=0.331 (e) (e) | P=1.000N P=0.482N (e) (e) |
|INCIDENTAL TUMOR | P=1.000 P=0.331 (e) (e) | P=0.999N P=0.045N* (e) (e) |
|LOGISTIC REGRESSION | P=1.000 P=0.331 (e) (e) | P=0.966N P=0.354N P=0.900N P=0.994N |
|COCHRAN-ARMITAGE | P=0.575N | P=0.243N |
|FISHER EXACT | P=0.496 (e) (e) | P=0.248N P=0.248N P=0.248N |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/59 (0%) 0/60 (0%) 0/60 (0%) | 0/59 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 4.6% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 0/6 (0%) 0/4 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 0/10 (0%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 1/42 (2%) 0/18 (0%) 0/0 0/0 | 0/41 (0%) 0/13 (0%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 615 --- --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.971N P=0.366N P=0.761N (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.630N P=0.121N P=0.099N P=0.638N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.552N P=0.265N P=0.459N P=0.660N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.242N | (e) |
|FISHER EXACT | P=0.252N P=0.248N P=0.248N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2,3-TRICHLOROPROPANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 41/59 (69%) 54/60 (90%) 55/60 (92%) | 0/60 (0%) 47/60 (78%) 55/60 (92%) 51/60 (85%) |
|ADJUSTED (b) | 0.0% 86.6% 100.0% 96.5% | 0.0% 95.9% 100.0% 97.9% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 1/8 (13%) 4/6 (67%) 4/4 (100%) | 0/10 (0%) 1/10 (10%) 6/9 (67%) 2/5 (40%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 5/6 (83%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 7/9 (78%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 10/10 (100%) 0/0 | 0/0 0/0 9/9 (100%) 0/0 |
|TERMINAL (d) | 0/42 (0%) 12/18 (67%) 0/0 0/0 | 0/41 (0%) 11/13 (85%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- 424 385 350 | --- 414 312 295 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 57/59 (97%) 57/60 (95%) 59/60 (98%) | 0/60 (0%) 54/60 (90%) 59/60 (98%) 59/60 (98%) |
|ADJUSTED (b) | 6.7% 100.0% 100.0% 100.0% | 0.0% 100.0% 100.0% 100.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 7/8 (88%) 4/6 (67%) 4/4 (100%) | 0/10 (0%) 6/10 (60%) 9/9 (100%) 5/5 (100%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 6/6 (100%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 9/9 (100%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 10/10 (100%) 0/0 | 0/0 0/0 9/9 (100%) 0/0 |
|TERMINAL (d) | 2/42 (5%) 18/18 (100%) 0/0 0/0 | 0/41 (0%) 13/13 (100%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 486 424 385 322 | --- 414 312 295 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2,3-TRICHLOROPROPANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 35/59 (59%) 25/60 (42%) 35/60 (58%) | 0/60 (0%) 28/60 (47%) 27/60 (45%) 33/60 (55%) |
|ADJUSTED (b) | 6.7% 88.0% 83.7% 90.0% | 0.0% 84.8% 73.1% 94.1% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 7/8 (88%) 3/6 (50%) 2/4 (50%) | 0/10 (0%) 5/10 (50%) 9/9 (100%) 4/5 (80%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 5/6 (83%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 6/9 (67%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 8/10 (80%) 0/0 | 0/0 0/0 5/9 (56%) 0/0 |
|TERMINAL (d) | 2/42 (5%) 14/18 (78%) 0/0 0/0 | 0/41 (0%) 9/13 (69%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 486 457 (I) 445 322 | --- 461 (I) 442 377 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.004 ** P<0.001 ** P=0.045 * P=0.014 * | P<0.001 ** P<0.001 ** P<0.001 ** P=0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/58 (2%) 1/59 (2%) 2/60 (3%) 0/60 (0%) | 0/59 (0%) 0/59 (0%) 0/58 (0%) 0/59 (0%) |
|ADJUSTED (b) | 2.4% 5.6% 3.7% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 1/6 (17%) 0/4 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 0/10 (0%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 1/41 (2%) 1/18 (6%) 0/0 0/0 | 0/41 (0%) 0/13 (0%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 452 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.649 P=0.568 P=0.199 (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.609N P=0.568 P=0.355 (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.391N P=0.568 P=0.600 (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.326N | (e) |
|FISHER EXACT | P=0.748N P=0.513 P=0.492N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2,3-TRICHLOROPROPANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Tongue |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/59 (0%) 0/60 (0%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 14.2% | 0.0% 0.0% 5.9% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 0/6 (0%) 0/4 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 1/9 (11%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 0/10 (0%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 0/42 (0%) 0/18 (0%) 0/0 0/0 | 0/41 (0%) 0/13 (0%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- 470 | --- --- 578 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.137 (e) (e) P=0.395 | P=0.789 (e) P=0.302 (e) |
|INCIDENTAL TUMOR | P=0.467 (e) (e) P=0.906 | P=0.950 (e) P=0.965 (e) |
|LOGISTIC REGRESSION | P=0.075 (e) (e) P=0.311 | P=0.861 (e) P=0.517 (e) |
|COCHRAN-ARMITAGE | P=0.042 * | P=0.786N |
|FISHER EXACT | (e) (e) P=0.248 | (e) P=0.500 (e) |
|=================================================================================================================================|
| |
|Uterus |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/60 (0%) 1/60 (2%) 0/60 (0%) 4/60 (7%) |
|ADJUSTED (b) | | 0.0% 7.7% 0.0% 25.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/9 (0%) 1/5 (20%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| | |
|INTERIM SACRIFICE 4 (c)| | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | | 0/41 (0%) 1/13 (8%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | | --- 733 (T) --- 461 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P<0.001 ** P=0.272 (e) P=0.001 ** |
|INCIDENTAL TUMOR | | P=0.027 * P=0.272 (e) P=0.288 |
|LOGISTIC REGRESSION | | P=0.009 ** P=0.272 (e) P=0.134 |
|COCHRAN-ARMITAGE | | P=0.011 * |
|FISHER EXACT | | P=0.500 (e) P=0.059 |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2,3-TRICHLOROPROPANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/60 (0%) 4/60 (7%) 3/60 (5%) 8/60 (13%) |
|ADJUSTED (b) | | 0.0% 25.4% 25.3% 64.2% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/9 (0%) 2/5 (40%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 3/6 (50%) |
|INTERIM SACRIFICE 3 (c)| | |
|INTERIM SACRIFICE 4 (c)| | 0/0 0/0 2/9 (22%) 0/0 |
|TERMINAL (d) | | 0/41 (0%) 2/13 (15%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | | --- 698 582 461 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P<0.001 ** P=0.002 ** P=0.278 P<0.001 ** |
|INCIDENTAL TUMOR | | P=0.001 ** P=0.036 * P=0.965 P=0.091 |
|LOGISTIC REGRESSION | | P<0.001 ** P=0.007 ** P=0.050 * P=0.017 * |
|COCHRAN-ARMITAGE | | P=0.006 ** |
|FISHER EXACT | | P=0.059 P=0.122 P=0.003 ** |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/60 (0%) 2/60 (3%) 2/60 (3%) 7/60 (12%) |
|ADJUSTED (b) | | 0.0% 11.2% 3.8% 28.6% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 1/9 (11%) 1/5 (20%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 1/6 (17%) |
|INTERIM SACRIFICE 3 (c)| | |
|INTERIM SACRIFICE 4 (c)| | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | | 0/41 (0%) 1/13 (8%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | | --- 643 312 379 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P<0.001 ** P=0.083 P=0.228 P=0.006 ** |
|INCIDENTAL TUMOR | | P=0.033 * P=0.260 P=0.300 P=0.251 |
|LOGISTIC REGRESSION | | P=0.023 * P=0.165 P=0.378 P=0.074 |
|COCHRAN-ARMITAGE | | P=0.002 ** |
|FISHER EXACT | | P=0.248 P=0.248 P=0.006 ** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2,3-TRICHLOROPROPANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/59 (3%) 1/60 (2%) 0/60 (0%) | 1/60 (2%) 1/60 (2%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 2.4% 6.0% 9.1% 0.0% | 2.4% 7.7% 8.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 0/6 (0%) 0/4 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 1/10 (10%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 1/42 (2%) 0/18 (0%) 0/0 0/0 | 1/41 (2%) 1/13 (8%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 541 623 (I) --- | 733 (T) 733 (T) 608 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.820N P=0.344 (e) (e) | P=0.589 P=0.488 P=0.235 (e) |
|INCIDENTAL TUMOR | P=0.292N P=0.649 (e) (e) | P=0.862 P=0.488 P=0.965 (e) |
|LOGISTIC REGRESSION | P=0.516N P=0.481 P=0.513 P=0.153N | P=0.813 P=0.488 P=0.546 (e) |
|COCHRAN-ARMITAGE | P=0.230N | P=0.323N |
|FISHER EXACT | P=0.494 P=0.752N P=0.500N | P=0.752N P=0.752N P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 0/59 (0%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 8.9% 0.0% 0.0% 0.0% | 0.0% 0.0% 7.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 0/6 (0%) 0/4 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 0/10 (0%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 2/42 (5%) 0/18 (0%) 0/0 0/0 | 0/41 (0%) 0/13 (0%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 533 --- --- --- | --- --- 603 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.478N P=0.142N P=0.433N P=0.740N | P=0.771 (e) P=0.250 (e) |
|INCIDENTAL TUMOR | P=0.083N P=0.032N* P=0.005N** P=0.096N | P=0.950 (e) P=0.965 (e) |
|LOGISTIC REGRESSION | P=0.153N P=0.068N P=0.096N P=0.153N | P=0.851 (e) P=0.468 (e) |
|COCHRAN-ARMITAGE | P=0.077N | P=0.786N |
|FISHER EXACT | P=0.061N P=0.059N P=0.059N | (e) P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2,3-TRICHLOROPROPANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 2/59 (3%) 1/60 (2%) 0/60 (0%) | 1/60 (2%) 1/60 (2%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | 8.9% 6.0% 9.1% 0.0% | 2.4% 7.7% 15.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 0/6 (0%) 0/4 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 1/10 (10%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 2/42 (5%) 0/18 (0%) 0/0 0/0 | 1/41 (2%) 1/13 (8%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 533 541 623 (I) --- | 733 (T) 733 (T) 603 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.450N P=0.539N P=0.433N P=0.740N | P=0.092 P=0.488 P=0.032 * (e) |
|INCIDENTAL TUMOR | P=0.027N* P=0.146N P=0.005N** P=0.096N | P=0.520 P=0.488 P=0.872 (e) |
|LOGISTIC REGRESSION | P=0.078N P=0.074N P=0.018N* P=0.153N | P=0.666 P=0.488 P=0.213 (e) |
|COCHRAN-ARMITAGE | P=0.052N | P=0.333N |
|FISHER EXACT | P=0.348N P=0.182N P=0.059N | P=0.752N P=0.500 P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/59 (2%) 1/60 (2%) 0/60 (0%) | 2/60 (3%) 1/60 (2%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 2.1% 2.9% 3.3% 0.0% | 4.4% 2.9% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 0/6 (0%) 0/4 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 0/10 (0%) 0/0 | 0/0 0/0 0/9 (0%) 0/0 |
|TERMINAL (d) | 0/42 (0%) 0/18 (0%) 0/0 0/0 | 1/41 (2%) 0/13 (0%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 495 620 540 --- | 480 600 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.705N P=0.730 P=0.685 P=0.665N | P=0.589N P=0.661N P=0.556N P=0.669N |
|INCIDENTAL TUMOR | P=0.099N P=0.494N P=0.355N P=0.094N | P=0.101N P=0.352N P=0.102N P=0.032N* |
|LOGISTIC REGRESSION | P=0.252N P=0.758N P=0.692N P=0.400N | P=0.197N P=0.473N P=0.227N P=0.277N |
|COCHRAN-ARMITAGE | P=0.321N | P=0.169N |
|FISHER EXACT | P=0.748 P=0.752N P=0.500N | P=0.500N P=0.248N P=0.248N |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2,3-TRICHLOROPROPANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 6/60 (10%) 5/59 (8%) 1/60 (2%) 1/60 (2%) | 17/60 (28%) 7/60 (12%) 3/60 (5%) 3/60 (5%) |
|ADJUSTED (b) | 13.5% 20.9% 3.3% 1.7% | 38.4% 41.2% 26.7% 11.7% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 0/6 (0%) 0/4 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 0/10 (0%) 0/0 | 0/0 0/0 2/9 (22%) 0/0 |
|TERMINAL (d) | 4/42 (10%) 2/18 (11%) 0/0 0/0 | 14/41 (34%) 4/13 (31%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 495 620 540 322 | 480 600 608 419 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.296 P=0.321 P=0.685 P=0.675 | P=0.003 ** P=0.465 P=0.585 P=0.107 |
|INCIDENTAL TUMOR | P=0.279N P=0.398N P=0.355N P=0.454N | P=0.629 P=0.222N P=0.200N P=0.286N |
|LOGISTIC REGRESSION | P=0.254N P=0.614 P=0.211N P=0.168N | P=0.235 P=0.216N P=0.588N P=0.613N |
|COCHRAN-ARMITAGE | P=0.033N* | P=0.002N** |
|FISHER EXACT | P=0.512N P=0.057N P=0.057N | P=0.019N* P<0.001N** P<0.001N** |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 4/59 (7%) 0/60 (0%) 1/60 (2%) | 15/60 (25%) 6/60 (10%) 3/60 (5%) 3/60 (5%) |
|ADJUSTED (b) | 11.6% 18.5% 0.0% 1.7% | 34.8% 39.5% 26.7% 11.7% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 0/8 (0%) 0/6 (0%) 0/4 (0%) | 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/5 (0%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 0/6 (0%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 0/10 (0%) 0/0 | 0/0 0/0 2/9 (22%) 0/0 |
|TERMINAL (d) | 4/42 (10%) 2/18 (11%) 0/0 0/0 | 13/41 (32%) 4/13 (31%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 682 660 --- 322 | 691 705 608 419 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.155 P=0.318 (e) P=0.503 | P<0.001 ** P=0.426 P=0.235 P=0.036 * |
|INCIDENTAL TUMOR | P=0.528 P=0.553N (e) P=0.638 | P=0.189 P=0.361N P=0.965 P=0.786 |
|LOGISTIC REGRESSION | P=0.670N P=0.518 P=0.786N P=0.517N | P=0.031 * P=0.558N P=0.297 P=0.511 |
|COCHRAN-ARMITAGE | P=0.062N | P=0.006N** |
|FISHER EXACT | P=0.511N P=0.029N* P=0.103N | P=0.026N* P=0.002N** P=0.002N** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 02 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2,3-TRICHLOROPROPANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 20/60 (33%) 49/59 (83%) 46/60 (77%) 50/60 (83%) | 20/60 (33%) 36/60 (60%) 40/60 (67%) 53/60 (88%) |
|ADJUSTED (b) | 41.2% 100.0% 100.0% 100.0% | 43.5% 96.8% 96.7% 100.0% |
|INTERIM SACRIFICE 1 (c)| 1/8 (13%) 7/8 (88%) 4/6 (67%) 3/4 (75%) | 3/10 (30%) 5/10 (50%) 9/9 (100%) 5/5 (100%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 6/6 (100%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 9/9 (100%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 10/10 (100%) 0/0 | 0/0 0/0 9/9 (100%) 0/0 |
|TERMINAL (d) | 14/42 (33%) 18/18 (100%) 0/0 0/0 | 16/41 (39%) 12/13 (92%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 457 (I) 424 388 322 | 461 (I) 461 (I) 312 377 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.004 ** P<0.001 ** P=0.018 * P=0.002 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** | P=0.003 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 15/60 (25%) 44/59 (75%) 56/60 (93%) 58/60 (97%) | 23/60 (38%) 48/60 (80%) 55/60 (92%) 58/60 (97%) |
|ADJUSTED (b) | 31.8% 89.6% 100.0% 96.7% | 48.5% 97.9% 100.0% 100.0% |
|INTERIM SACRIFICE 1 (c)| 0/8 (0%) 1/8 (13%) 4/6 (67%) 4/4 (100%) | 0/10 (0%) 1/10 (10%) 6/9 (67%) 5/5 (100%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 6/6 (100%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 7/9 (78%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 10/10 (100%) 0/0 | 0/0 0/0 9/9 (100%) 0/0 |
|TERMINAL (d) | 10/42 (24%) 13/18 (72%) 0/0 0/0 | 17/41 (41%) 12/13 (92%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 495 424 385 322 | 68 414 312 295 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 02 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- 1,2,3-TRICHLOROPROPANE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG | 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 30/60 (50%) 57/59 (97%) 59/60 (98%) 60/60 (100%)| 39/60 (65%) 54/60 (90%) 59/60 (98%) 60/60 (100%)|
|ADJUSTED (b) | 58.7% 100.0% 100.0% 100.0% | 76.2% 100.0% 100.0% 100.0% |
|INTERIM SACRIFICE 1 (c)| 1/8 (13%) 7/8 (88%) 5/6 (83%) 4/4 (100%) | 3/10 (30%) 6/10 (60%) 9/9 (100%) 5/5 (100%) |
|INTERIM SACRIFICE 2 (c)| | 0/0 0/0 0/0 6/6 (100%) |
|INTERIM SACRIFICE 3 (c)| 0/0 0/0 0/0 9/9 (100%) | |
|INTERIM SACRIFICE 4 (c)| 0/0 0/0 10/10 (100%) 0/0 | 0/0 0/0 9/9 (100%) 0/0 |
|TERMINAL (d) | 21/42 (50%) 18/18 (100%) 0/0 0/0 | 29/41 (71%) 13/13 (100%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 457 (I) 424 385 322 | 68 414 312 295 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P=0.003 ** P<0.001 ** | P<0.001 ** P=0.011 * P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 457 554 623
Female interim sacrifices(days): 461 511 620
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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