TDMS Study 05111-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/14/94
EXP: 05111 1,2,3-TRICHLOROPROPANE TIME: 08:57:51
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: C60220
CONT: NO1-ES-45048 CAS: 96-18-4
PATHOLOGIST: K. MURTHY
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/14/94
EXP: 05111 1,2,3-TRICHLOROPROPANE TIME: 08:57:51
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: C60220
CONT: NO1-ES-45048 CAS: 96-18-4
PATHOLOGIST: K. MURTHY
1,2,3-TRICHLOROPROPANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 10 CENSORED DEATHS 8 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 16 458 458 486 495 533 592 615 655 682 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 6 MG/KG |
| --------------------- |
| |
| TOTAL 59 UNCENSORED DEATHS 33 CENSORED DEATHS 8 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 400 424 451 458 520 520 535 541 541 561 |
| 561 571 577 581 583 585 590 620 636 639 |
| 639 641 645 652 660 677 678 678 680 688 |
| 690 707 710 |
| CENSORED DEATHS |
| 457 457 457 457 457 457 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 20 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 44 CENSORED DEATHS 16 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 385 388 410 436 445 445 452 458 458 469 |
| 472 473 477 477 477 478 498 498 505 505 |
| 514 526 527 535 540 540 542 560 561 561 |
| 561 563 576 577 582 582 590 591 592 597 |
| 610 611 616 623 |
| CENSORED DEATHS |
| 457 457 457 457 459 459 623 623 623 623 |
| 623 623 623 623 623 623 |
| |
==================================================================================
1,2,3-TRICHLOROPROPANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 60 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 47 CENSORED DEATHS 13 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 322 350 366 368 379 388 389 392 393 406 |
| 413 417 423 428 429 435 437 437 442 444 |
| 445 452 452 455 458 461 465 470 471 471 |
| 473 478 488 490 490 497 499 504 507 514 |
| 520 532 534 539 541 542 553 |
| CENSORED DEATHS |
| 457 457 457 459 554 554 554 554 554 554 |
| 554 554 554 |
| |
==================================================================================
1,2,3-TRICHLOROPROPANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 98.3 98.3 98.3 98.3 98.3 94.6 88.8 86.9 83.0 81.1 |
| | |
| | |
|6 MG/KG | 100.0 100.0 100.0 100.0 96.6 93.0 83.1 67.3 51.5 35.6 |
| | |
| | |
|20 MG/KG | 100.0 100.0 100.0 100.0 95.0 71.5 50.8 26.4 0.0 0.0 |
| | |
| | |
|60 MG/KG | 100.0 100.0 100.0 96.7 78.3 45.0 18.8 0.0 0.0 0.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 81.1% 35.6% 0.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P<0.001 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 499.0 595.1 520.1 454.4 |
|NATURAL DEATHS (C) | (59.4) (14.5) ( 9.6) ( 8.1) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 654.5 617.3 531.0 469.6 |
|(STANDARD ERROR) | (17.7) (13.9) ( 9.2) ( 7.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
1,2,3-TRICHLOROPROPANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 9 CENSORED DEATHS 10 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 68 480 482 511 631 691 699 699 728 |
| CENSORED DEATHS |
| 461 461 461 461 461 461 463 463 463 463 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 6 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 37 CENSORED DEATHS 10 TERMINAL 13 |
| |
| UNCENSORED DEATHS |
| 160 207 414 448 516 540 557 558 566 571 |
| 574 580 582 583 587 600 601 603 607 609 |
| 623 624 629 634 643 653 671 676 680 687 |
| 687 693 698 705 719 721 728 |
| CENSORED DEATHS |
| 461 461 461 461 461 461 463 463 463 463 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 20 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 41 CENSORED DEATHS 19 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 312 382 441 442 446 454 458 462 465 465 |
| 467 469 473 494 494 501 502 502 502 509 |
| 511 522 523 532 540 545 551 558 560 565 |
| 570 573 573 578 580 582 589 603 608 617 |
| 620 |
| CENSORED DEATHS |
| 11 461 461 461 461 461 463 463 463 463 |
| 620 620 620 620 620 620 620 620 620 |
| |
==================================================================================
1,2,3-TRICHLOROPROPANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 60 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 49 CENSORED DEATHS 11 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 295 341 377 378 379 379 383 383 390 397 |
| 405 407 411 419 420 424 427 432 434 439 |
| 442 445 445 447 460 466 467 468 469 469 |
| 469 473 473 473 480 480 487 487 490 491 |
| 494 496 498 501 504 505 506 508 508 |
| CENSORED DEATHS |
| 461 461 461 463 463 511 511 511 511 511 |
| 511 |
| |
==================================================================================
1,2,3-TRICHLOROPROPANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 98.3 98.3 98.3 98.3 98.3 94.3 92.3 92.3 90.3 82.3 |
| | |
| | |
|6 MG/KG | 100.0 98.3 96.7 96.7 95.0 93.3 89.3 64.9 48.7 26.4 |
| | |
| | |
|20 MG/KG | 100.0 100.0 100.0 98.3 96.6 76.0 49.3 24.6 0.0 0.0 |
| | |
| | |
|60 MG/KG | 100.0 100.0 100.0 96.7 73.3 36.9 0.0 0.0 0.0 0.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 6 MG/KG 20 MG/KG 60 MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 82.3% 26.4% 0.0% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P<0.001 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 554.3 592.8 515.6 445.3 |
|NATURAL DEATHS (C) | (69.3) (20.1) (10.3) ( 7.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 661.0 601.4 514.8 453.3 |
|(STANDARD ERROR) | (17.3) (16.5) (12.5) ( 6.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
1,2,3-TRICHLOROPROPANE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
6 MG/KG = 2
20 MG/KG = 3
60 MG/KG = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 1 4 3 2
| 1 4 4 4 33 23 2 21
| 3 3 21 1
| 4 44 33 2 11 2
90 + 3 3 1 2 1 1
| 44 33 22 1 1
| 44 33 1 1
| 444 33 2 2 1 1
80 + 44 33 22 1 1
| 44 22
| 44
| 3 3 22
P 70 + 44 2 2
E | 33 2 2
R | 4 4 33 2 2
C | 3 3 22
E 60 + 44
N | 44 333 22
T | 44 22
| 2 2 2
S 50 + 3 33
U | 44
R | 44 22
V | 3 3 22
I 40 + 44 2 2
V | 44 33 22
A | 44 3 3 2 2
L | 44
30 + 4 4
| 444 33 3
|
| 44
20 + 44 33 3
| 44
|
|
10 +
|
|
|
0 + 4 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 17 obs hidden.
1,2,3-TRICHLOROPROPANE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
6 MG/KG = 2
20 MG/KG = 3
60 MG/KG = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 1 2 4 3
| 1 2 2 4 3 4 4 3 2 3 1
| 2 32 1 1
| 4 4 2 3 12 2 1
90 + 33 2 2 1 1
| 44 33 11
| 44 22 1 1
| 444 22 1 1
80 + 22
| 44 33 22
| 44 3 3
| 44 33
P 70 + 2 2
E | 444 22
R |
C | 33
E 60 + 4 4 3 3 2 22
N | 44
T | 33 22
| 3 3 22
S 50 + 33 2 2
U | 44 33 2 22
R | 22
V | 33 22
I 40 + 44 33
V | 44 22
A | 33 22
L | 2 2
30 + 44 33 3
| 3 3 22 2
| 44
| 3 3
20 + 44
|
|
| 44
10 +
|
|
|
0 + 4 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 15 obs hidden.
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