TDMS Study 05111-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
1,2,3-TRICHLOROPROPANE
NTP Experiment-Test: 05111-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/14/94
Route: GAVAGE Time: 05:10:26
Facility: TSI Mason Research
Chemical CAS #: 96-18-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05111-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 09/14/94
Route: GAVAGE Time: 05:10:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 8 8
Early Deaths
Moribund 17 17 42 50
Dead 2 2 2 2
Survivors
Terminal Sacrifice 31 30 8
Wrong Sex 1
Animals Examined Microscopically 60 59 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (58) (59) (60) (60)
Hyperkeratosis 1 (2%) 15 (25%) 31 (52%)
Intestine Large, Cecum (59) (57) (59) (59)
Atrophy 2 (3%)
Epithelium, Hyperplasia 1 (2%)
Intestine Large, Colon (59) (57) (60) (59)
Diverticulum 1 (2%)
Liver (60) (59) (60) (60)
Basophilic Focus 23 (38%) 29 (49%) 20 (33%) 10 (17%)
Bile Stasis 1 (2%)
Clear Cell Focus 1 (2%) 2 (3%) 1 (2%)
Eosinophilic Focus 1 (2%) 2 (3%) 2 (3%) 3 (5%)
Fatty Change, Diffuse 1 (2%)
Fatty Change, Focal 3 (5%) 2 (3%) 2 (3%)
Fibrosis 1 (2%)
Hepatodiaphragmatic Nodule 2 (3%) 3 (5%) 11 (18%) 6 (10%)
Hepatodiaphragmatic Nodule, Multiple 1 (2%)
Hyperplasia 2 (3%) 3 (5%) 1 (2%) 1 (2%)
Inflammation, Granulomatous 6 (10%) 5 (8%)
Mineralization 1 (2%)
Mitotic Alteration 1 (2%)
Mixed Cell Focus 4 (7%) 6 (10%) 3 (5%)
Necrosis 1 (2%) 4 (7%)
Bile Duct, Hyperplasia 1 (2%) 5 (8%)
Mesentery (2) (5) (4) (1)
Fat, Inflammation, Chronic Active 1 (50%)
Fat, Necrosis 1 (50%) 4 (80%) 3 (75%)
Pancreas (60) (59) (60) (60)
Acinus, Atrophy 10 (17%) 9 (15%) 9 (15%) 3 (5%)
Acinus, Hyperplasia 5 (8%) 15 (25%) 24 (40%) 11 (18%)
Pharynx (1) (3) (18) (23)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05111-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 09/14/94
Route: GAVAGE Time: 05:10:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hyperplasia, Squamous 1 (6%)
Palate, Abscess 1 (6%) 1 (4%)
Palate, Hyperplasia, Basal Cell 1 (100%) 1 (6%) 1 (4%)
Palate, Hyperplasia, Squamous 1 (6%)
Salivary Glands (60) (59) (60) (60)
Inflammation, Chronic Active 1 (2%)
Duct, Metaplasia, Squamous 5 (8%) 3 (5%)
Stomach, Forestomach (60) (59) (59) (60)
Hyperplasia, Basal Cell 10 (17%) 5 (8%) 9 (15%)
Hyperplasia, Squamous 1 (2%) 26 (44%) 15 (25%) 16 (27%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Mineralization 2 (3%)
Ulcer 1 (2%) 1 (2%) 2 (3%) 1 (2%)
Stomach, Glandular (60) (59) (60) (59)
Hyperplasia 2 (3%)
Mineralization 2 (3%) 1 (2%)
Tongue (10) (4) (21) (35)
Acanthosis 3 (9%)
Hyperkeratosis 1 (5%) 3 (9%)
Hyperplasia, Squamous 1 (25%)
Inflammation, Acute 1 (25%) 6 (29%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (59) (60) (58)
Cardiomyopathy 18 (30%) 22 (37%) 17 (28%) 9 (16%)
Artery, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (59) (58) (60) (57)
Degeneration, Fatty 2 (3%) 1 (2%)
Hyperplasia 2 (3%) 1 (2%)
Adrenal Gland, Medulla (59) (56) (59) (57)
Hyperplasia 7 (12%) 5 (9%) 3 (5%)
Islets, Pancreatic (60) (58) (60) (60)
Hyperplasia 1 (2%)
Metaplasia 1 (2%) 2 (3%) 1 (2%)
Pituitary Gland (60) (58) (59) (59)
Pars Distalis, Angiectasis 19 (32%) 21 (36%) 11 (19%) 4 (7%)
Pars Distalis, Cyst 12 (20%) 7 (12%) 11 (19%) 1 (2%)
Pars Distalis, Hyperplasia 24 (40%) 22 (38%) 25 (42%) 7 (12%)
Pars Intermedia, Cyst 3 (5%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (60) (57) (60) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05111-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 09/14/94
Route: GAVAGE Time: 05:10:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
C-Cell, Hyperplasia 7 (12%) 7 (12%) 8 (13%)
Follicle, Cyst 1 (2%)
Follicle, Hemorrhage 1 (2%)
Follicular Cell, Hyperplasia 3 (5%) 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (56) (56) (58) (59)
Hyperplasia 2 (4%) 3 (5%) 3 (5%)
Necrosis 3 (5%)
Ovary (60) (58) (60) (60)
Cyst 4 (7%) 3 (5%) 8 (13%) 3 (5%)
Interstitial Cell, Hyperplasia 1 (2%)
Uterus (60) (58) (60) (60)
Cyst 2 (3%)
Decidual Reaction 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Endometrium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (58) (60) (60)
Myelofibrosis 1 (2%)
Lymph Node (60) (59) (60) (60)
Mediastinal, Pigmentation 3 (5%) 3 (5%) 5 (8%)
Pancreatic, Pigmentation 2 (3%)
Lymph Node, Mandibular (58) (57) (60) (58)
Degeneration 4 (7%)
Lymph Node, Mesenteric (60) (58) (59) (57)
Angiectasis 4 (7%) 2 (3%)
Spleen (60) (57) (60) (59)
Angiectasis 1 (2%)
Depletion Lymphoid 3 (5%)
Fibrosis 3 (5%) 1 (2%)
Hematopoietic Cell Proliferation 25 (42%) 27 (47%) 40 (67%) 32 (54%)
Infiltration Cellular, Histiocyte 1 (2%) 1 (2%)
Thymus (56) (56) (59) (57)
Depletion Lymphoid 2 (4%)
Epithelial Cell, Hyperplasia 1 (2%) 4 (7%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05111-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 09/14/94
Route: GAVAGE Time: 05:10:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (57) (55) (53) (50)
Galactocele 11 (19%) 15 (27%) 11 (21%) 1 (2%)
Skin (60) (59) (59) (59)
Acanthosis 1 (2%) 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (59) (60) (59)
Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (59) (60) (60)
Hemorrhage 1 (2%)
Hydrocephalus 1 (2%)
Hyperplasia, Reticulum Cell 1 (2%)
Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (58) (59) (60)
Edema 1 (2%)
Embolus Tumor 1 (2%)
Fibrosis 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 5 (8%) 2 (3%) 5 (8%)
Inflammation, Acute 1 (2%) 2 (3%)
Alveolar Epithelium, Hyperplasia 2 (3%) 2 (3%) 2 (3%) 1 (2%)
Nose (60) (59) (60) (60)
Fungus 1 (2%)
Inflammation, Acute 2 (3%) 1 (2%) 2 (3%) 6 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (5) (11) (19)
Hemorrhage 1 (25%) 2 (11%)
Inflammation, Acute 2 (18%) 2 (11%)
Synechia 1 (25%) 1 (20%) 2 (18%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05111-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 09/14/94
Route: GAVAGE Time: 05:10:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Lens, Cataract 1 (20%) 3 (27%) 5 (26%)
Retina, Atrophy 2 (40%) 4 (36%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (57) (60) (59)
Cyst 1 (2%)
Infarct 1 (2%)
Nephropathy 18 (30%) 21 (37%) 18 (30%) 8 (14%)
Cortex, Mineralization 1 (2%) 1 (2%) 5 (8%)
Papilla, Mineralization 1 (2%) 1 (2%)
Renal Tubule, Hyperplasia 2 (4%) 3 (5%) 12 (20%)
Renal Tubule, Regeneration 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05111-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 09/14/94
Route: GAVAGE Time: 05:10:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 9
Early Deaths
Moribund 13 16 30 43
Dead 2 2 4
Accident 1 1
Survivors
Terminal Sacrifice 34 32 14
Wrong Sex 1
Animals Examined Microscopically 60 60 59 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (59) (59) (59)
Hyperkeratosis 2 (3%) 3 (5%) 8 (14%) 35 (59%)
Inflammation, Acute 1 (2%)
Necrosis 1 (2%) 1 (2%)
Intestine Large, Colon (60) (60) (58) (60)
Edema 1 (2%)
Intestine Small, Duodenum (59) (60) (58) (60)
Inflammation, Acute 1 (2%)
Intestine Small, Ileum (59) (60) (57) (59)
Ulcer 1 (2%)
Intestine Small, Jejunum (59) (60) (57) (60)
Diverticulum 1 (2%)
Inflammation, Chronic Active 1 (2%)
Metaplasia, Osseous 1 (2%)
Liver (60) (60) (59) (60)
Basophilic Focus 12 (20%) 8 (13%) 18 (31%) 10 (17%)
Clear Cell Focus 2 (3%) 5 (8%) 4 (7%) 5 (8%)
Congestion 1 (2%)
Cyst 1 (2%)
Eosinophilic Focus 2 (3%) 3 (5%)
Fatty Change, Focal 11 (18%) 9 (15%) 3 (5%) 1 (2%)
Fibrosis 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 3 (5%) 6 (10%) 2 (3%)
Hyperplasia 1 (2%) 2 (3%)
Infarct 2 (3%)
Mixed Cell Focus 7 (12%) 8 (13%) 6 (10%) 7 (12%)
Pigmentation 1 (2%)
Bile Duct, Hyperplasia 1 (2%) 2 (3%) 6 (10%) 20 (33%)
Mesentery (5) (9) (12) (5)
Fat, Fibrosis 1 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05111-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 09/14/94
Route: GAVAGE Time: 05:10:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Hemorrhage 1 (8%)
Fat, Inflammation, Chronic Active 1 (20%) 1 (8%) 1 (20%)
Fat, Mineralization 1 (20%) 2 (22%) 4 (33%)
Fat, Necrosis 4 (44%) 3 (25%)
Fat, Pigmentation 1 (11%) 1 (20%)
Pancreas (60) (60) (59) (60)
Acinus, Atrophy 10 (17%) 13 (22%) 8 (14%) 2 (3%)
Acinus, Hyperplasia 28 (47%) 46 (77%) 53 (90%) 57 (95%)
Acinus, Hyperplasia, Multiple 2 (3%)
Artery, Inflammation, Chronic Active 6 (10%) 2 (3%) 1 (2%)
Pharynx (1) (5) (18) (16)
Hyperplasia, Basal Cell 1 (6%)
Hyperplasia, Squamous 1 (6%)
Palate, Hyperplasia, Basal Cell 1 (20%) 2 (13%)
Palate, Hyperplasia, Squamous 1 (6%) 1 (6%)
Palate, Ulcer 1 (6%)
Salivary Glands (60) (60) (59) (60)
Duct, Metaplasia, Squamous 1 (2%) 2 (3%) 6 (10%)
Stomach, Forestomach (60) (60) (59) (60)
Cyst Epithelial Inclusion 1 (2%)
Hyperplasia, Basal Cell 7 (12%) 12 (20%) 9 (15%)
Hyperplasia, Squamous 3 (5%) 28 (47%) 13 (22%) 6 (10%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (3%)
Ulcer 1 (2%) 2 (3%) 7 (12%) 2 (3%)
Stomach, Glandular (60) (60) (59) (60)
Fibrosis 1 (2%)
Hyperplasia 2 (3%)
Mineralization 1 (2%)
Tongue (14) (8) (13) (47)
Acanthosis 2 (15%)
Hyperkeratosis 3 (21%) 2 (25%) 1 (8%) 5 (11%)
Hyperplasia, Basal Cell 1 (7%) 2 (4%)
Hyperplasia, Squamous 1 (13%)
Inflammation, Acute 1 (8%) 16 (34%)
Inflammation, Chronic Active 1 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (59) (59) (60)
Cardiomyopathy 39 (65%) 43 (73%) 37 (63%) 27 (45%)
Fibrosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05111-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 09/14/94
Route: GAVAGE Time: 05:10:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (60) (58) (59)
Degeneration, Fatty 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Adrenal Gland, Medulla (59) (60) (58) (59)
Hyperplasia 10 (17%) 8 (13%) 9 (16%) 3 (5%)
Islets, Pancreatic (60) (60) (59) (60)
Hyperplasia 5 (8%) 2 (3%) 1 (2%) 2 (3%)
Parathyroid Gland (57) (55) (57) (53)
Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (58) (58) (59) (59)
Pars Distalis, Angiectasis 7 (12%) 10 (17%) 3 (5%) 1 (2%)
Pars Distalis, Cyst 3 (5%) 1 (2%) 2 (3%)
Pars Distalis, Hyperplasia 7 (12%) 11 (19%) 14 (24%) 10 (17%)
Pars Distalis, Hyperplasia, Multifocal 1 (2%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (60) (59) (59) (59)
C-Cell, Hyperplasia 5 (8%) 3 (5%) 8 (14%) 4 (7%)
Follicle, Cyst 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%) 4 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (59) (57) (59) (58)
Abscess 2 (3%) 2 (3%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Prostate (58) (60) (59) (60)
Hyperplasia 7 (12%) 4 (7%) 10 (17%) 2 (3%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Testes (60) (60) (59) (60)
Interstitial Cell, Hyperplasia 16 (27%) 14 (23%) 13 (22%) 24 (40%)
Seminiferous Tubule, Atrophy 5 (8%) 5 (8%) 3 (5%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05111-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 09/14/94
Route: GAVAGE Time: 05:10:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (59) (60)
Myelofibrosis 1 (2%)
Lymph Node (60) (60) (59) (60)
Mediastinal, Angiectasis 1 (2%) 2 (3%) 1 (2%)
Mediastinal, Infiltration Cellular,
Polymorphonuclear 1 (2%)
Mediastinal, Pigmentation 1 (2%) 2 (3%) 2 (3%) 3 (5%)
Lymph Node, Mandibular (60) (60) (58) (60)
Angiectasis 1 (2%)
Degeneration 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Lymph Node, Mesenteric (60) (59) (57) (59)
Angiectasis 1 (2%)
Degeneration 1 (2%)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%) 1 (2%)
Spleen (60) (60) (59) (60)
Fibrosis 1 (2%) 5 (8%) 1 (2%) 2 (3%)
Hematopoietic Cell Proliferation 15 (25%) 24 (40%) 31 (53%) 31 (52%)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Mineralization 1 (2%)
Pigmentation 2 (3%)
Thymus (59) (58) (51) (56)
Cyst 1 (2%)
Depletion Lymphoid 1 (2%) 1 (2%)
Epithelial Cell, Hyperplasia 4 (7%) 2 (3%) 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (51) (50) (41) (46)
Galactocele 1 (2%) 3 (6%) 2 (5%)
Hyperplasia 1 (2%)
Skin (60) (58) (58) (59)
Acanthosis 1 (2%)
Fibrosis 2 (3%)
Hemorrhage 1 (2%)
Hyperkeratosis 1 (2%) 2 (3%) 3 (5%)
Inflammation, Chronic Active 4 (7%) 1 (2%)
Necrosis 2 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05111-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 09/14/94
Route: GAVAGE Time: 05:10:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (59) (60)
Fibrous Osteodystrophy 1 (2%)
Skeletal Muscle (2) (3) (5) (3)
Inflammation, Acute 1 (20%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (59) (59) (60)
Edema 1 (2%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%) 3 (5%)
Inflammation, Acute 4 (7%) 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (7%)
Mediastinum, Inflammation, Acute 1 (2%)
Nose (60) (60) (59) (60)
Fungus 8 (13%) 6 (10%) 6 (10%) 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Acute 7 (12%) 7 (12%) 10 (17%) 6 (10%)
Nasolacrimal Duct, Inflammation, Acute 1 (2%)
Respiratory Epithelium, Hyperplasia 1 (2%) 3 (5%) 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (2) (7) (8)
Synechia 1 (50%) 1 (14%) 1 (13%)
Lens, Cataract 1 (50%) 1 (50%) 4 (57%) 4 (50%)
Retina, Atrophy 1 (14%)
Harderian Gland (1) (1) (2)
Hemorrhage 1 (100%)
Hyperplasia 1 (100%)
Zymbal's Gland (4)
Necrosis 1 (25%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05111-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 09/14/94
Route: GAVAGE Time: 05:10:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (59) (60)
Cyst 1 (2%) 3 (5%)
Hydronephrosis 1 (2%)
Necrosis 1 (2%) 1 (2%)
Nephropathy 58 (97%) 60 (100%) 58 (98%) 60 (100%)
Bilateral, Hydronephrosis 1 (2%)
Cortex, Mineralization 3 (5%)
Renal Tubule, Hyperplasia 1 (2%) 23 (39%) 36 (60%)
Renal Tubule, Hyperplasia, Eosinophil 2 (3%)
Urinary Bladder (59) (60) (57) (60)
Calculus Gross Observation 1 (2%) 1 (2%) 4 (7%)
Calculus Micro Observation Only 1 (2%) 1 (2%) 1 (2%) 4 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------
--multipart-boundary
Content-type: text/plain
Range: bytes 74820-74820/74820
--multipart-boundary--