TDMS Study 05111-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 1,2,3-TRICHLOROPROPANE DATE: 09/14/94
EXPERIMENT: 05111 TEST: 01 TIME: 05:25:07
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-45048 ROUTE: GAVAGE NTP C#: 60220B
PATHOLOGIST: K. MURTHY S. EUSTIS CAS: 96-18-4
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 1,2,3-TRICHLOROPROPANE DATE: 09/14/94
EXPERIMENT: 05111 TEST: 01 TIME: 05:25:07
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45048 ROUTE: GAVAGE NTP C#: 60220B
PATHOLOGIST: K. MURTHY S. EUSTIS CAS: 96-18-4
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 1,2,3-TRICHLOROPROPANE DATE: 09/14/94
EXPERIMENT: 05111 TEST: 01 TIME: 05:25:07
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45048 ROUTE: GAVAGE NTP C#: 60220B
PATHOLOGIST: K. MURTHY S. EUSTIS CAS: 96-18-4
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF 1,2,3-TRICHLOROPROPANE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Clitoral/Preputial Gland Adenoma
Carcinoma
Carcinoma or Adenoma
Intestine Small Carcinoma
Islets, Pancreatic Adenoma
Carcinoma or Adenoma
Kidney: Renal Tubule Adenoma
Carcinoma or Adenoma
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip)
Papilloma Squamous or Papilloma
Squamous Cell Carcinoma
Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
Pancreas Adenoma
Carcinoma or Adenoma
Pharynx Squamous Cell Carcinoma
Squamous Cell Papilloma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Skin Keratoacanthoma
Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
Squamous Cell Papilloma
Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma,
Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma
Skin: Subcutaneous Tissue Fibroma
Neurofibrosarcoma, Fibrosarcoma, Sarcoma,
Neurofibroma, or Fibroma
Stomach, Forestomach Squamous Cell Carcinoma
Squamous Cell Carcinoma or Papilloma Squamous
Squamous Cell Papilloma
Testes Adenoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
Thyroid Gland: Follicular Cell
Adenoma
Carcinoma or Adenoma
Tongue Squamous Cell Carcinoma
Squamous Cell Carcinoma or Papilloma Squamous
Squamous Cell Papilloma
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 1,2,3-TRICHLOROPROPANE DATE: 09/14/94
EXPERIMENT: 05111 TEST: 01 TIME: 05:25:07
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45048 ROUTE: GAVAGE NTP C#: 60220B
PATHOLOGIST: K. MURTHY S. EUSTIS CAS: 96-18-4
Zymbal's Gland Carcinoma
All Organs Hemangioma
Hemangiosarcoma or Hemangioma
Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Mesothelioma Benign, Malignant, NOS
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Clitoral/Preputial Gland Adenoma
Carcinoma
Carcinoma or Adenoma
Intestine Small Carcinoma
Mammary Gland Adenoma
Carcinoma
Carcinoma or Adenoma
Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip)
Papilloma Squamous or Papilloma
Squamous Cell Carcinoma
Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
Pancreas Adenoma
Carcinoma or Adenoma
Pharynx Squamous Cell Carcinoma
Squamous Cell Papilloma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Stomach, Forestomach Squamous Cell Carcinoma
Squamous Cell Carcinoma or Papilloma Squamous
Squamous Cell Papilloma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
Thyroid Gland: Follicular Cell
Adenoma
Carcinoma or Adenoma
Tongue Squamous Cell Carcinoma
Squamous Cell Carcinoma or Papilloma Squamous
Squamous Cell Papilloma
Uterus Adenoma
Polyp Stromal
Sarcoma Stromal or Polyp Stromal
Zymbal's Gland Carcinoma
All Organs Hemangiosarcoma or Hemangioma
Leukemia: Lymphocytic, Monocytic, Mononuclear,
or Undifferentiated
Benign Tumors
Malignant Tumors
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason 1,2,3-TRICHLOROPROPANE DATE: 09/14/94
EXPERIMENT: 05111 TEST: 01 TIME: 05:25:07
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45048 ROUTE: GAVAGE NTP C#: 60220B
PATHOLOGIST: K. MURTHY S. EUSTIS CAS: 96-18-4
Malignant and Benign Tumors
====================================================================================================
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/60 (17%) 7/60 (12%) 13/58 (22%) 0/59 (0%) | 5/59 (8%) 2/57 (4%) 1/60 (2%) 0/58 (0%) |
|ADJUSTED (b) | 27.6% 19.7% 54.1% 0.0% | 16.7% 6.5% 12.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 8/34 (24%) 5/32 (16%) 5/14 (36%) 0/0 | 5/30 (17%) 1/29 (3%) 1/8 (13%) 0/0 |
|FIRST INCIDENCE (DAYS) | 663 600 596 --- | 736 (T) 725 736 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.009 ** P=0.322N P=0.013 * (e) | P=0.757N P=0.226N P=0.601N (e) |
|INCIDENTAL TUMOR | P=0.106 P=0.233N P=0.169 (e) | P=0.686N P=0.222N P=0.601N (e) |
|LOGISTIC REGRESSION | P=0.196 P=0.256N P=0.076 P=0.842N | P=0.702N P=0.210N P=0.601N (e) |
|COCHRAN-ARMITAGE | P=0.004N** | P=0.032N* |
|FISHER EXACT | P=0.301N P=0.289 P<0.001N** | P=0.234N P=0.100N P=0.030N* |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 2/58 (3%) 0/59 (0%) | 2/59 (3%) 0/57 (0%) 0/60 (0%) 0/58 (0%) |
|ADJUSTED (b) | 2.9% 2.5% 14.3% 0.0% | 6.7% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 1/34 (3%) 0/32 (0%) 2/14 (14%) 0/0 | 2/30 (7%) 0/29 (0%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 685 729 (T) --- | 736 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.463 P=0.752N P=0.209 (e) | P=0.876N P=0.245N P=0.555N (e) |
|INCIDENTAL TUMOR | P=0.603 P=0.676N P=0.209 (e) | P=0.876N P=0.245N P=0.555N (e) |
|LOGISTIC REGRESSION | P=0.583 P=0.752N P=0.209 (e) | P=0.876N P=0.245N P=0.555N (e) |
|COCHRAN-ARMITAGE | P=0.338N | P=0.243N |
|FISHER EXACT | P=0.752N P=0.487 P=0.504N | P=0.257N P=0.244N P=0.252N |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/60 (18%) 8/60 (13%) 14/58 (24%) 0/59 (0%) | 7/59 (12%) 2/57 (4%) 1/60 (2%) 0/58 (0%) |
|ADJUSTED (b) | 30.4% 21.7% 59.2% 0.0% | 23.3% 6.5% 12.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 9/34 (26%) 5/32 (16%) 6/14 (43%) 0/0 | 7/30 (23%) 1/29 (3%) 1/8 (13%) 0/0 |
|FIRST INCIDENCE (DAYS) | 663 600 596 --- | 736 (T) 725 736 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.007 ** P=0.327N P=0.009 ** (e) | P=0.540N P=0.085N P=0.430N (e) |
|INCIDENTAL TUMOR | P=0.103 P=0.212N P=0.124 (e) | P=0.472N P=0.083N P=0.430N (e) |
|LOGISTIC REGRESSION | P=0.174 P=0.261N P=0.065 P=0.853N | P=0.476N P=0.075N P=0.430N (e) |
|COCHRAN-ARMITAGE | P=0.002N** | P=0.012N* |
|FISHER EXACT | P=0.309N P=0.293 P<0.001N** | P=0.090N P=0.029N* P=0.007N** |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/59 (8%) 3/57 (5%) 6/59 (10%) 11/58 (19%) | 5/56 (9%) 11/56 (20%) 14/58 (24%) 12/59 (20%) |
|ADJUSTED (b) | 13.6% 9.6% 25.6% 55.5% | 17.0% 31.5% 83.1% 49.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/8 (0%) | 0/10 (0%) 1/10 (10%) 1/8 (13%) 2/8 (25%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 3/9 (33%) | |
|TERMINAL (d) | 4/34 (12%) 2/29 (7%) 2/14 (14%) 0/0 | 4/28 (14%) 7/29 (24%) 6/8 (75%) 0/0 |
|FIRST INCIDENCE (DAYS) | 506 703 450 (I) 459 | 717 465 (I) 463 (I) 310 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.421N P=0.154 P<0.001 ** | P<0.001 ** P=0.105 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.256 P=0.510N P=0.388 P=0.466N | P=0.004 ** P=0.104 P<0.001 ** P=0.123 |
|LOGISTIC REGRESSION | P=0.002 ** P=0.363N P=0.404 P=0.023 * | P<0.001 ** P=0.098 P=0.001 ** P=0.030 * |
|COCHRAN-ARMITAGE | P=0.014 * | P=0.187 |
|FISHER EXACT | P=0.378N P=0.500 P=0.083 | P=0.088 P=0.026 * P=0.071 |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/59 (0%) 3/57 (5%) 3/59 (5%) 6/58 (10%) | 0/56 (0%) 0/56 (0%) 4/58 (7%) 6/59 (10%) |
|ADJUSTED (b) | 0.0% 7.4% 10.9% 15.9% | 0.0% 0.0% 7.5% 15.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/8 (13%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 0/34 (0%) 0/29 (0%) 1/14 (7%) 0/0 | 0/28 (0%) 0/29 (0%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 654 404 382 | --- --- 434 331 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.143 P=0.070 P=0.005 ** | P<0.001 ** (e) P=0.059 P=0.004 ** |
|INCIDENTAL TUMOR | P=0.434 P=0.302 P=0.212 P=0.326 | P=0.451N (e) P=0.403 P=0.747 |
|LOGISTIC REGRESSION | P=0.103 P=0.118 P=0.152 P=0.164 | P=0.404 (e) P=0.176 P=0.246 |
|COCHRAN-ARMITAGE | P=0.021 * | P=0.003 ** |
|FISHER EXACT | P=0.115 P=0.122 P=0.013 * | (e) P=0.064 P=0.016 * |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/59 (8%) 6/57 (11%) 9/59 (15%) 17/58 (29%) | 5/56 (9%) 11/56 (20%) 18/58 (31%) 17/59 (29%) |
|ADJUSTED (b) | 13.6% 16.4% 34.6% 62.7% | 17.0% 31.5% 84.4% 56.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 1/8 (13%) | 0/10 (0%) 1/10 (10%) 1/8 (13%) 2/8 (25%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 3/9 (33%) | |
|TERMINAL (d) | 4/34 (12%) 2/29 (7%) 3/14 (21%) 0/0 | 4/28 (14%) 7/29 (24%) 6/8 (75%) 0/0 |
|FIRST INCIDENCE (DAYS) | 506 654 404 382 | 717 465 (I) 434 310 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.463 P=0.028 * P<0.001 ** | P<0.001 ** P=0.105 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.179 P=0.524 P=0.176 P=0.616 | P=0.023 * P=0.104 P<0.001 ** P=0.097 |
|LOGISTIC REGRESSION | P<0.001 ** P=0.491 P=0.163 P=0.007 ** | P<0.001 ** P=0.098 P<0.001 ** P=0.013 * |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.020 * |
|FISHER EXACT | P=0.476 P=0.197 P=0.004 ** | P=0.088 P=0.003 ** P=0.006 ** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Ear |
| Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/60 (2%) 2/59 (3%) 0/60 (0%) | 0/60 (0%) 0/59 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 3.1% 10.9% 0.0% | 0.0% 0.0% 2.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 0/34 (0%) 1/32 (3%) 1/14 (7%) 0/0 | 0/31 (0%) 0/30 (0%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 669 --- | --- --- 510 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.291 P=0.488 P=0.117 (e) | P=0.842 (e) P=0.482 (e) |
|INCIDENTAL TUMOR | P=0.435 P=0.488 P=0.241 (e) | P=0.537N (e) P=0.761 (e) |
|LOGISTIC REGRESSION | P=0.474 P=0.488 P=0.168 (e) | P=0.771N (e) P=0.593 (e) |
|COCHRAN-ARMITAGE | P=0.515N | P=0.785N |
|FISHER EXACT | P=0.500 P=0.244 (e) | (e) P=0.500 (e) |
|=================================================================================================================================|
| |
|Intestine Small: Jejunum |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 1/59 (2%) 1/60 (2%) | 0/60 (0%) 0/59 (0%) 1/60 (2%) 2/60 (3%) |
|ADJUSTED (b) | 0.0% 0.0% 2.7% 4.3% | 0.0% 0.0% 7.1% 15.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 1/8 (13%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 0/34 (0%) 0/32 (0%) 0/14 (0%) 0/0 | 0/31 (0%) 0/30 (0%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 590 487 | --- --- 699 407 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.041 * (e) P=0.457 P=0.353 | P=0.003 ** (e) P=0.318 P=0.115 |
|INCIDENTAL TUMOR | P=0.457 (e) P=0.443 P=0.983 | P=0.055 (e) P=0.500 P=0.377 |
|LOGISTIC REGRESSION | P=0.408 (e) P=0.516 P=0.677 | P=0.071 (e) P=0.383 P=0.348 |
|COCHRAN-ARMITAGE | P=0.303 | P=0.085 |
|FISHER EXACT | (e) P=0.496 P=0.500 | (e) P=0.500 P=0.248 |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/60 (15%) 4/60 (7%) 3/59 (5%) 1/60 (2%) | 2/60 (3%) 2/58 (3%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 24.4% 11.3% 17.3% 3.4% | 6.5% 6.7% 0.0% 4.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 7/34 (21%) 3/32 (9%) 2/14 (14%) 0/0 | 2/31 (6%) 2/30 (7%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 614 603 660 479 | 736 (T) 736 (T) --- 399 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.436 P=0.132N P=0.387N P=0.395 | P=0.212 P=0.684 P=0.563N P=0.318 |
|INCIDENTAL TUMOR | P=0.541N P=0.127N P=0.225N P=0.983 | P=0.592 P=0.684 P=0.563N P=0.860 |
|LOGISTIC REGRESSION | P=0.392N P=0.100N P=0.175N P=0.712N | P=0.528 P=0.684 P=0.563N P=0.669 |
|COCHRAN-ARMITAGE | P=0.015N* | P=0.378N |
|FISHER EXACT | P=0.120N P=0.067N P=0.008N** | P=0.678 P=0.248N P=0.500N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/60 (17%) 4/60 (7%) 3/59 (5%) 1/60 (2%) | 3/60 (5%) 3/58 (5%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 27.2% 11.3% 17.3% 3.4% | 9.4% 9.3% 0.0% 4.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 8/34 (24%) 3/32 (9%) 2/14 (14%) 0/0 | 2/31 (6%) 2/30 (7%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 614 603 660 479 | 717 696 --- 399 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.504 P=0.087N P=0.320N P=0.395 | P=0.305 P=0.653 P=0.408N P=0.318 |
|INCIDENTAL TUMOR | P=0.471N P=0.083N P=0.177N P=0.983 | P=0.724 P=0.642N P=0.293N P=0.860 |
|LOGISTIC REGRESSION | P=0.343N P=0.061N P=0.126N P=0.724N | P=0.649 P=0.652N P=0.331N P=0.667 |
|COCHRAN-ARMITAGE | P=0.010N** | P=0.191N |
|FISHER EXACT | P=0.077N P=0.040N* P=0.004N** | P=0.644 P=0.122N P=0.309N |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 20/59 (34%) 26/60 (43%) | 0/60 (0%) 0/57 (0%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 0.0% 6.3% 76.3% 85.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 5/8 (63%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 6/9 (67%) | |
|TERMINAL (d) | 0/34 (0%) 2/32 (6%) 8/14 (57%) 0/0 | 0/31 (0%) 0/30 (0%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 660 423 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.225 P<0.001 ** P<0.001 ** | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P<0.001 ** P=0.225 P<0.001 ** P=0.006 ** | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P<0.001 ** P=0.225 P<0.001 ** P<0.001 ** | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P<0.001 ** | (e) |
|FISHER EXACT | P=0.248 P<0.001 ** P<0.001 ** | (e) (e) (e) |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 20/59 (34%) 26/60 (43%) | 0/60 (0%) 0/57 (0%) 0/60 (0%) 1/59 (2%) |
|ADJUSTED (b) | 0.0% 6.3% 76.3% 85.0% | 0.0% 0.0% 0.0% 5.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 5/8 (63%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 6/9 (67%) | |
|TERMINAL (d) | 0/34 (0%) 2/32 (6%) 8/14 (57%) 0/0 | 0/31 (0%) 0/30 (0%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 660 423 | --- --- --- 408 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.225 P<0.001 ** P<0.001 ** | P=0.067 (e) (e) P=0.282 |
|INCIDENTAL TUMOR | P<0.001 ** P=0.225 P<0.001 ** P=0.006 ** | P=0.466 (e) (e) P=0.853 |
|LOGISTIC REGRESSION | P<0.001 ** P=0.225 P<0.001 ** P<0.001 ** | P=0.474 (e) (e) P=0.769 |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.214 |
|FISHER EXACT | P=0.248 P<0.001 ** P<0.001 ** | (e) (e) P=0.496 |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 3/59 (5%) 1/60 (2%) | 0/60 (0%) 0/59 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 2.9% 3.1% 19.3% 9.1% | 0.0% 0.0% 12.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 1/34 (3%) 1/32 (3%) 2/14 (14%) 0/0 | 0/31 (0%) 0/30 (0%) 1/8 (13%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 709 520 | --- --- 736 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002 ** P=0.748 P=0.076 P=0.214 | P=0.788 (e) P=0.233 (e) |
|INCIDENTAL TUMOR | P=0.204 P=0.748 P=0.166 P=0.983 | P=0.788 (e) P=0.233 (e) |
|LOGISTIC REGRESSION | P=0.054 P=0.748 P=0.120 P=0.601 | P=0.788 (e) P=0.233 (e) |
|COCHRAN-ARMITAGE | P=0.618N | P=0.785N |
|FISHER EXACT | P=0.752N P=0.303 P=0.752N | (e) P=0.500 (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 1/59 (2%) 2/60 (3%) | 0/60 (0%) 0/59 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 4.0% 13.3% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 1/9 (11%) | |
|TERMINAL (d) | 0/34 (0%) 0/32 (0%) 0/14 (0%) 0/0 | 0/31 (0%) 0/30 (0%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 669 452 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.073 (e) P=0.427 P=0.440 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.541 (e) P=0.742 P=0.983 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.117 (e) P=0.465 P=0.381 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.084 | (e) |
|FISHER EXACT | (e) P=0.496 P=0.248 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 4/59 (7%) 3/60 (5%) | 0/60 (0%) 0/59 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 2.9% 3.1% 22.6% 21.2% | 0.0% 0.0% 12.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 1/9 (11%) | |
|TERMINAL (d) | 1/34 (3%) 1/32 (3%) 2/14 (14%) 0/0 | 0/31 (0%) 0/30 (0%) 1/8 (13%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 669 452 | --- --- 736 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.748 P=0.034 * P=0.080 | P=0.788 (e) P=0.233 (e) |
|INCIDENTAL TUMOR | P=0.113 P=0.748 P=0.131 P=0.913 | P=0.788 (e) P=0.233 (e) |
|LOGISTIC REGRESSION | P=0.011 * P=0.748 P=0.073 P=0.216 | P=0.788 (e) P=0.233 (e) |
|COCHRAN-ARMITAGE | P=0.223 | P=0.785N |
|FISHER EXACT | P=0.752N P=0.177 P=0.309 | (e) P=0.500 (e) |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 4/59 (7%) 3/60 (5%) | 0/60 (0%) 0/59 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 2.9% 3.1% 22.6% 21.2% | 0.0% 0.0% 12.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 1/9 (11%) | |
|TERMINAL (d) | 1/34 (3%) 1/32 (3%) 2/14 (14%) 0/0 | 0/31 (0%) 0/30 (0%) 1/8 (13%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 669 452 | --- --- 736 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.748 P=0.034 * P=0.080 | P=0.788 (e) P=0.233 (e) |
|INCIDENTAL TUMOR | P=0.113 P=0.748 P=0.131 P=0.913 | P=0.788 (e) P=0.233 (e) |
|LOGISTIC REGRESSION | P=0.011 * P=0.748 P=0.073 P=0.216 | P=0.788 (e) P=0.233 (e) |
|COCHRAN-ARMITAGE | P=0.223 | P=0.785N |
|FISHER EXACT | P=0.752N P=0.177 P=0.309 | (e) P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/59 (2%) 2/59 (3%) 2/60 (3%) | 2/60 (3%) 1/58 (2%) 1/59 (2%) 0/60 (0%) |
|ADJUSTED (b) | 5.5% 3.2% 11.2% 7.9% | 5.6% 3.4% 2.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/8 (13%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 1/34 (3%) 1/31 (3%) 1/14 (7%) 0/0 | 1/31 (3%) 1/29 (3%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 663 729 (T) 684 452 (I) | 645 736 (T) 510 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.007 ** P=0.510N P=0.456 P=0.120 | P=0.904 P=0.513N P=0.729 (e) |
|INCIDENTAL TUMOR | P=0.150 P=0.424N P=0.667N P=0.424 | P=0.352N P=0.492N P=0.503N (e) |
|LOGISTIC REGRESSION | P=0.221 P=0.491N P=0.575 P=0.610 | P=0.481N P=0.504N P=0.536N P=0.949N |
|COCHRAN-ARMITAGE | P=0.532 | P=0.192N |
|FISHER EXACT | P=0.506N P=0.684 P=0.691N | P=0.513N P=0.506N P=0.248N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/59 (0%) 2/59 (3%) 0/60 (0%) | 0/60 (0%) 0/58 (0%) 1/59 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 10.0% 0.0% | 0.0% 0.0% 2.9% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 0/34 (0%) 0/31 (0%) 1/14 (7%) 0/0 | 0/31 (0%) 0/29 (0%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 641 --- | --- --- 561 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.278 (e) P=0.130 (e) | P=0.834 (e) P=0.453 (e) |
|INCIDENTAL TUMOR | P=0.282 (e) P=0.123 (e) | P=0.947 (e) P=0.718 (e) |
|LOGISTIC REGRESSION | P=0.552 (e) P=0.183 (e) | P=0.877N (e) P=0.547 (e) |
|COCHRAN-ARMITAGE | P=0.695N | P=0.783N |
|FISHER EXACT | (e) P=0.244 (e) | (e) P=0.496 (e) |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/59 (2%) 4/59 (7%) 2/60 (3%) | 2/60 (3%) 1/58 (2%) 2/59 (3%) 0/60 (0%) |
|ADJUSTED (b) | 5.5% 3.2% 20.6% 7.9% | 5.6% 3.4% 5.2% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/8 (13%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 1/34 (3%) 1/31 (3%) 2/14 (14%) 0/0 | 1/31 (3%) 1/29 (3%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 663 729 (T) 641 452 (I) | 645 736 (T) 510 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.001 ** P=0.510N P=0.118 P=0.120 | P=0.644 P=0.513N P=0.467 (e) |
|INCIDENTAL TUMOR | P=0.041 * P=0.424N P=0.274 P=0.424 | P=0.442N P=0.492N P=0.615N (e) |
|LOGISTIC REGRESSION | P=0.132 P=0.491N P=0.209 P=0.610 | P=0.471N P=0.504N P=0.699 P=0.949N |
|COCHRAN-ARMITAGE | P=0.547 | P=0.209N |
|FISHER EXACT | P=0.506N P=0.332 P=0.691N | P=0.513N P=0.684 P=0.248N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/59 (0%) 0/60 (0%) | 1/60 (2%) 0/59 (0%) 3/60 (5%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 3.0% 0.0% 15.2% 16.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 1/8 (13%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 0/34 (0%) 0/32 (0%) 0/14 (0%) 0/0 | 0/31 (0%) 0/30 (0%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 714 --- 521 465 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.022 * P=0.506N P=0.109 P=0.455 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.373 P=0.460N P=0.522 P=0.455 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.337 P=0.497N P=0.256 P=0.625 |
|COCHRAN-ARMITAGE | (e) | P=0.560 |
|FISHER EXACT | (e) (e) (e) | P=0.504N P=0.309 P=0.752N |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/59 (0%) 0/60 (0%) | 1/60 (2%) 6/59 (10%) 12/60 (20%) 22/60 (37%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 1.7% 17.7% 51.7% 63.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 1/8 (13%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 0/34 (0%) 0/32 (0%) 0/14 (0%) 0/0 | 0/31 (0%) 4/30 (13%) 3/8 (38%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 450 469 424 239 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P<0.001 ** P=0.059 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.010 ** P=0.071 P=0.011 * P=0.229 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P<0.001 ** P=0.057 P=0.003 ** P=0.014 * |
|COCHRAN-ARMITAGE | (e) | P<0.001 ** |
|FISHER EXACT | (e) (e) (e) | P=0.054 P=0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/59 (0%) 0/60 (0%) | 2/60 (3%) 6/59 (10%) 14/60 (23%) 23/60 (38%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 4.7% 17.7% 58.0% 70.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 2/8 (25%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 0/34 (0%) 0/32 (0%) 0/14 (0%) 0/0 | 0/31 (0%) 4/30 (13%) 3/8 (38%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 450 469 424 239 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P<0.001 ** P=0.135 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.003 ** P=0.166 P=0.016 * P=0.123 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P<0.001 ** P=0.132 P=0.002 ** P=0.009 ** |
|COCHRAN-ARMITAGE | (e) | P<0.001 ** |
|FISHER EXACT | (e) (e) (e) | P=0.131 P=0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 3/60 (5%) 2/59 (3%) 0/60 (0%) | 15/60 (25%) 23/59 (39%) 20/60 (33%) 1/60 (2%) |
|ADJUSTED (b) | 5.9% 8.6% 14.3% 0.0% | 40.1% 61.6% 88.2% 3.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 2/34 (6%) 2/32 (6%) 2/14 (14%) 0/0 | 10/31 (32%) 16/30 (53%) 6/8 (75%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 685 729 (T) --- | 474 604 510 371 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.595 P=0.490 P=0.352 (e) | P<0.001 ** P=0.081 P<0.001 ** P=0.375 |
|INCIDENTAL TUMOR | P=0.696 P=0.554 P=0.352 (e) | P=0.358 P=0.059 P=0.033 * P=0.311N |
|LOGISTIC REGRESSION | P=0.701 P=0.520 P=0.352 (e) | P=0.249 P=0.078 P=0.016 * P=0.306N |
|COCHRAN-ARMITAGE | P=0.117N | P<0.001N** |
|FISHER EXACT | P=0.500 P=0.684 P=0.248N | P=0.075 P=0.211 P<0.001N** |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 3/60 (5%) 2/59 (3%) 0/60 (0%) | 16/60 (27%) 23/59 (39%) 22/60 (37%) 2/60 (3%) |
|ADJUSTED (b) | 5.9% 8.6% 14.3% 0.0% | 41.9% 61.6% 88.9% 19.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 1/8 (13%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 2/34 (6%) 2/32 (6%) 2/14 (14%) 0/0 | 10/31 (32%) 16/30 (53%) 6/8 (75%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 685 729 (T) --- | 474 604 510 371 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.595 P=0.490 P=0.352 (e) | P<0.001 ** P=0.118 P<0.001 ** P=0.152 |
|INCIDENTAL TUMOR | P=0.696 P=0.554 P=0.352 (e) | P=0.269 P=0.092 P=0.038 * P=0.681N |
|LOGISTIC REGRESSION | P=0.701 P=0.520 P=0.352 (e) | P=0.048 * P=0.114 P=0.012 * P=0.524N |
|COCHRAN-ARMITAGE | P=0.117N | P<0.001N** |
|FISHER EXACT | P=0.500 P=0.684 P=0.248N | P=0.108 P=0.163 P<0.001N** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 3/60 (5%) 2/59 (3%) 0/60 (0%) | 17/60 (28%) 26/59 (44%) 29/60 (48%) 24/60 (40%) |
|ADJUSTED (b) | 5.9% 8.6% 14.3% 0.0% | 42.9% 67.8% 95.3% 71.4% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 2/8 (25%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 2/34 (6%) 2/32 (6%) 2/14 (14%) 0/0 | 10/31 (32%) 18/30 (60%) 7/8 (88%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 685 729 (T) --- | 450 469 424 239 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.595 P=0.490 P=0.352 (e) | P<0.001 ** P=0.065 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.696 P=0.554 P=0.352 (e) | P=0.003 ** P=0.049 * P=0.010 * P=0.300 |
|LOGISTIC REGRESSION | P=0.701 P=0.520 P=0.352 (e) | P<0.001 ** P=0.057 P=0.002 ** P=0.078 |
|COCHRAN-ARMITAGE | P=0.117N | P=0.315 |
|FISHER EXACT | P=0.500 P=0.684 P=0.248N | P=0.055 P=0.019 * P=0.124 |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Papilloma Squamous or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 4/60 (7%) 10/59 (17%) 22/60 (37%) | 1/60 (2%) 5/59 (8%) 10/60 (17%) 21/60 (35%) |
|ADJUSTED (b) | 0.0% 11.7% 39.3% 61.5% | 3.2% 14.1% 58.7% 75.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 3/8 (38%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 3/8 (38%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 2/9 (22%) | |
|TERMINAL (d) | 0/34 (0%) 2/32 (6%) 3/14 (21%) 0/0 | 1/31 (3%) 2/30 (7%) 4/8 (50%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 694 452 (I) 337 | 736 (T) 664 405 233 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.062 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.112 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.117 P=0.004 ** P=0.028 * | P<0.001 ** P=0.122 P=0.001 ** P=0.010 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.069 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.106 P=0.003 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.059 P<0.001 ** P<0.001 ** | P=0.100 P=0.004 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 11/59 (19%) 25/60 (42%) | 0/60 (0%) 1/59 (2%) 21/60 (35%) 23/60 (38%) |
|ADJUSTED (b) | 2.9% 0.0% 47.6% 65.6% | 0.0% 3.3% 72.5% 73.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 2/8 (25%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 1/9 (11%) | |
|TERMINAL (d) | 1/34 (3%) 0/32 (0%) 4/14 (29%) 0/0 | 0/31 (0%) 1/30 (3%) 3/8 (38%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 404 327 | --- 736 (T) 513 294 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.512N P<0.001 ** P<0.001 ** | P<0.001 ** P=0.493 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.512N P=0.006 ** P=0.151 | P<0.001 ** P=0.493 P<0.001 ** P=0.017 * |
|LOGISTIC REGRESSION | P<0.001 ** P=0.512N P<0.001 ** P<0.001 ** | P<0.001 ** P=0.493 P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.500N P=0.002 ** P<0.001 ** | P=0.496 P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 4/60 (7%) 19/59 (32%) 43/60 (72%) | 1/60 (2%) 6/59 (10%) 28/60 (47%) 37/60 (62%) |
|ADJUSTED (b) | 2.9% 11.7% 66.4% 85.6% | 3.2% 17.2% 90.3% 91.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 3/8 (38%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 5/8 (63%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 3/9 (33%) | |
|TERMINAL (d) | 1/34 (3%) 2/32 (6%) 6/14 (43%) 0/0 | 1/31 (3%) 3/30 (10%) 6/8 (75%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 694 404 327 | 736 (T) 664 405 233 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.173 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.064 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.274 P<0.001 ** P=0.001 ** | P<0.001 ** P=0.069 P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.192 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.061 P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.182 P<0.001 ** P<0.001 ** | P=0.054 P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 21/60 (35%) 37/59 (63%) 31/60 (52%) | 0/60 (0%) 0/59 (0%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | 14.7% 58.0% 100.0% 96.4% | 0.0% 0.0% 19.2% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 2/8 (25%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 8/9 (89%) | |
|TERMINAL (d) | 5/34 (15%) 17/32 (53%) 14/14 (100%) 0/0 | 0/31 (0%) 0/30 (0%) 1/8 (13%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 685 450 (I) 423 | --- --- 701 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P=0.153 (e) P=0.046 * (e) |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P=0.049 * | P=0.258 (e) P=0.108 (e) |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P=0.253 (e) P=0.080 (e) |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.696N |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** | (e) P=0.248 (e) |
|=================================================================================================================================|
| |
|Pancreas |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 2/59 (3%) 1/60 (2%) | 0/60 (0%) 0/59 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 12.9% 11.1% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 1/9 (11%) | |
|TERMINAL (d) | 0/34 (0%) 0/32 (0%) 1/14 (7%) 0/0 | 0/31 (0%) 0/30 (0%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- 720 534 (I) | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.218 (e) P=0.086 (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.426 (e) P=0.241 (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.056 (e) P=0.113 P=0.566 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.350 | (e) |
|FISHER EXACT | (e) P=0.244 P=0.500 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Pancreas |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 21/60 (35%) 37/59 (63%) 31/60 (52%) | 0/60 (0%) 0/59 (0%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | 14.7% 58.0% 100.0% 96.4% | 0.0% 0.0% 19.2% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 2/8 (25%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 8/9 (89%) | |
|TERMINAL (d) | 5/34 (15%) 17/32 (53%) 14/14 (100%) 0/0 | 0/31 (0%) 0/30 (0%) 1/8 (13%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 685 450 (I) 423 | --- --- 701 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P=0.153 (e) P=0.046 * (e) |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P=0.049 * | P=0.258 (e) P=0.108 (e) |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P=0.253 (e) P=0.080 (e) |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.696N |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** | (e) P=0.248 (e) |
|=================================================================================================================================|
| |
|Pharynx |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) 11/59 (19%) 7/60 (12%) | 0/60 (0%) 1/59 (2%) 10/60 (17%) 16/60 (27%) |
|ADJUSTED (b) | 2.9% 0.0% 47.6% 21.8% | 0.0% 3.3% 45.6% 61.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 1/8 (13%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 1/34 (3%) 0/32 (0%) 4/14 (29%) 0/0 | 0/31 (0%) 1/30 (3%) 1/8 (13%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 404 423 | --- 736 (T) 538 330 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.512N P<0.001 ** P=0.001 ** | P<0.001 ** P=0.493 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.077 P=0.512N P=0.006 ** P=0.626 | P<0.001 ** P=0.493 P=0.008 ** P=0.058 |
|LOGISTIC REGRESSION | P=0.003 ** P=0.512N P<0.001 ** P=0.114 | P<0.001 ** P=0.493 P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.015 * | P<0.001 ** |
|FISHER EXACT | P=0.500N P=0.002 ** P=0.031 * | P=0.496 P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Pharynx |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 1/59 (2%) 4/60 (7%) | 1/60 (2%) 2/59 (3%) 5/60 (8%) 3/60 (5%) |
|ADJUSTED (b) | 0.0% 6.1% 4.2% 19.2% | 3.2% 5.6% 30.2% 26.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/8 (13%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 1/8 (13%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 1/9 (11%) | |
|TERMINAL (d) | 0/34 (0%) 1/32 (3%) 0/14 (0%) 0/0 | 1/31 (3%) 0/30 (0%) 2/8 (25%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 710 678 424 | 736 (T) 664 405 336 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.001 ** P=0.230 P=0.425 P=0.059 | P<0.001 ** P=0.508 P=0.012 * P=0.030 * |
|INCIDENTAL TUMOR | P=0.124 P=0.324 P=0.742 P=0.397 | P=0.245 P=0.543 P=0.057 P=0.377 |
|LOGISTIC REGRESSION | P=0.046 * P=0.247 P=0.458 P=0.196 | P=0.145 P=0.505 P=0.092 P=0.242 |
|COCHRAN-ARMITAGE | P=0.048 * | P=0.323 |
|FISHER EXACT | P=0.248 P=0.496 P=0.059 | P=0.494 P=0.103 P=0.309 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 9/58 (16%) 15/58 (26%) 8/59 (14%) 2/59 (3%) | 29/60 (48%) 30/58 (52%) 12/59 (20%) 5/59 (8%) |
|ADJUSTED (b) | 25.1% 34.3% 35.8% 14.5% | 70.0% 76.4% 57.1% 36.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 2/10 (20%) 1/10 (10%) 0/8 (0%) | 1/10 (10%) 1/10 (10%) 0/8 (0%) 2/8 (25%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 1/9 (11%) | |
|TERMINAL (d) | 6/32 (19%) 6/31 (19%) 3/14 (21%) 0/0 | 19/31 (61%) 21/30 (70%) 2/8 (25%) 0/0 |
|FIRST INCIDENCE (DAYS) | 648 450 (I) 450 (I) 484 | 463 (I) 465 (I) 520 331 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.343 P=0.150 P=0.214 P=0.374 | P=0.004 ** P=0.459 P=0.486 P=0.027 * |
|INCIDENTAL TUMOR | P=0.337N P=0.205 P=0.464N P=0.982 | P=0.068N P=0.456 P=0.019N* P=0.336N |
|LOGISTIC REGRESSION | P=0.153N P=0.139 P=0.519 P=0.615 | P=0.300N P=0.498 P=0.028N* P=0.622N |
|COCHRAN-ARMITAGE | P=0.003N** | P<0.001N** |
|FISHER EXACT | P=0.126 P=0.485N P=0.025N* | P=0.427 P=0.001N** P<0.001N** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Prostate |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/58 (0%) 0/60 (0%) 2/59 (3%) 0/60 (0%) | |
|ADJUSTED (b) | 0.0% 0.0% 11.8% 0.0% | |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 0/32 (0%) 0/32 (0%) 1/14 (7%) 0/0 | |
|FIRST INCIDENCE (DAYS) | --- --- 686 --- | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.240 (e) P=0.106 (e) | |
|INCIDENTAL TUMOR | P=0.431 (e) P=0.248 (e) | |
|LOGISTIC REGRESSION | P=0.415 (e) P=0.166 (e) | |
|COCHRAN-ARMITAGE | P=0.693N | |
|FISHER EXACT | (e) P=0.252 (e) | |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 2/60 (3%) 1/59 (2%) 2/60 (3%) | 0/60 (0%) 0/59 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 5.9% 5.7% 7.1% 8.2% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 2/34 (6%) 1/32 (3%) 1/14 (7%) 0/0 | 0/31 (0%) 0/30 (0%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 689 729 (T) 478 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.015 * P=0.685 P=0.687 P=0.107 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.548 P=0.637N P=0.687 P=0.913 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.225 P=0.680N P=0.687 P=0.435 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.619 | (e) |
|FISHER EXACT | P=0.691N P=0.506N P=0.691N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 1/59 (2%) 6/60 (10%) | 1/60 (2%) 0/59 (0%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 5.7% 2.8% 30.5% | 3.2% 0.0% 16.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 3/8 (38%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 2/9 (22%) | |
|TERMINAL (d) | 0/34 (0%) 1/32 (3%) 0/14 (0%) 0/0 | 1/31 (3%) 0/30 (0%) 1/8 (13%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 689 596 450 (I) | 736 (T) --- 637 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.242 P=0.455 P=0.026 * | P=0.373 P=0.507N P=0.156 (e) |
|INCIDENTAL TUMOR | P=0.004 ** P=0.324 P=0.443 P=0.073 | P=0.630 P=0.507N P=0.320 (e) |
|LOGISTIC REGRESSION | P=0.014 * P=0.248 P=0.512 P=0.073 | P=0.585 P=0.507N P=0.289 (e) |
|COCHRAN-ARMITAGE | P=0.005 ** | P=0.454N |
|FISHER EXACT | P=0.248 P=0.496 P=0.014 * | P=0.504N P=0.500 P=0.500N |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 0/59 (0%) 5/60 (8%) | 0/60 (0%) 0/59 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 5.7% 0.0% 27.7% | 0.0% 0.0% 12.5% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 3/8 (38%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 2/9 (22%) | |
|TERMINAL (d) | 0/34 (0%) 1/32 (3%) 0/14 (0%) 0/0 | 0/31 (0%) 0/30 (0%) 1/8 (13%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 689 --- 450 (I) | --- --- 736 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.005 ** P=0.242 (e) P=0.074 | P=0.788 (e) P=0.233 (e) |
|INCIDENTAL TUMOR | P=0.007 ** P=0.324 (e) P=0.074 | P=0.788 (e) P=0.233 (e) |
|LOGISTIC REGRESSION | P=0.023 * P=0.248 (e) P=0.111 | P=0.788 (e) P=0.233 (e) |
|COCHRAN-ARMITAGE | P=0.010 * | P=0.785N |
|FISHER EXACT | P=0.248 (e) P=0.029 * | (e) P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 3/60 (5%) 3/59 (5%) 9/60 (15%) | 1/60 (2%) 0/59 (0%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | 8.8% 8.7% 15.4% 38.4% | 3.2% 0.0% 16.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 3/8 (38%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 2/9 (22%) | |
|TERMINAL (d) | 3/34 (9%) 2/32 (6%) 1/14 (7%) 0/0 | 1/31 (3%) 0/30 (0%) 1/8 (13%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 689 596 450 (I) | 736 (T) --- 637 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.645 P=0.305 P=0.001 ** | P=0.373 P=0.507N P=0.156 (e) |
|INCIDENTAL TUMOR | P=0.003 ** P=0.624N P=0.452 P=0.067 | P=0.630 P=0.507N P=0.320 (e) |
|LOGISTIC REGRESSION | P=0.002 ** P=0.647N P=0.494 P=0.034 * | P=0.585 P=0.507N P=0.289 (e) |
|COCHRAN-ARMITAGE | P=0.014 * | P=0.454N |
|FISHER EXACT | P=0.660N P=0.652 P=0.063 | P=0.504N P=0.500 P=0.500N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 2/60 (3%) 6/59 (10%) 1/60 (2%) | 0/60 (0%) 1/59 (2%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 5.2% 5.7% 34.0% 9.1% | 0.0% 2.2% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 1/34 (3%) 1/32 (3%) 4/14 (29%) 0/0 | 0/31 (0%) 0/30 (0%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 614 692 524 520 | --- 510 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.001 ** P=0.690 P=0.016 * P=0.214 | P=0.983N P=0.496 (e) (e) |
|INCIDENTAL TUMOR | P=0.446 P=0.658N P=0.051 P=0.983 | P=0.310N P=0.545 (e) (e) |
|LOGISTIC REGRESSION | P=0.189 P=0.682N P=0.068 P=0.814 | P=0.468N P=0.491 (e) (e) |
|COCHRAN-ARMITAGE | P=0.373N | P=0.575N |
|FISHER EXACT | P=0.691N P=0.131 P=0.500N | P=0.496 (e) (e) |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 3/60 (5%) 7/59 (12%) 1/60 (2%) | 1/60 (2%) 1/59 (2%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 7.6% 8.0% 36.5% 9.1% | 3.1% 2.2% 5.6% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 1/34 (3%) 1/32 (3%) 4/14 (29%) 0/0 | 0/31 (0%) 0/30 (0%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 614 663 524 520 | 717 510 643 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002 ** P=0.646N P=0.024 * P=0.214 | P=0.863 P=0.758 P=0.541 (e) |
|INCIDENTAL TUMOR | P=0.516 P=0.590N P=0.093 P=0.983 | P=0.292N P=0.713N P=0.642N (e) |
|LOGISTIC REGRESSION | P=0.254 P=0.652N P=0.086 P=0.694N | P=0.513N P=0.756 P=0.681 (e) |
|COCHRAN-ARMITAGE | P=0.229N | P=0.321N |
|FISHER EXACT | P=0.660N P=0.154 P=0.309N | P=0.748 P=0.752N P=0.500N |
|=================================================================================================================================|
| |
|Spleen |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) 0/59 (0%) 0/60 (0%) | 0/60 (0%) 0/57 (0%) 0/60 (0%) 0/59 (0%) |
|ADJUSTED (b) | 5.9% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 2/34 (6%) 0/32 (0%) 0/14 (0%) 0/0 | 0/31 (0%) 0/30 (0%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.797N P=0.252N P=0.448N (e) | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.797N P=0.252N P=0.448N (e) | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.797N P=0.252N P=0.448N (e) | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.243N | (e) |
|FISHER EXACT | P=0.248N P=0.252N P=0.248N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 9/60 (15%) 28/59 (47%) 14/60 (23%) | 0/60 (0%) 3/59 (5%) 9/60 (15%) 6/60 (10%) |
|ADJUSTED (b) | 0.0% 24.3% 89.4% 57.6% | 0.0% 9.4% 57.6% 48.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 1/8 (13%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 2/8 (25%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 2/9 (22%) | |
|TERMINAL (d) | 0/34 (0%) 6/32 (19%) 11/14 (79%) 0/0 | 0/31 (0%) 2/30 (7%) 3/8 (38%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 600 450 (I) 423 | --- 713 628 325 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.003 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.121 P<0.001 ** P=0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.002 ** P<0.001 ** P=0.232 | P<0.001 ** P=0.130 P<0.001 ** P=0.127 |
|LOGISTIC REGRESSION | P<0.001 ** P=0.003 ** P<0.001 ** P=0.001 ** | P<0.001 ** P=0.124 P<0.001 ** P=0.046 * |
|COCHRAN-ARMITAGE | P=0.012 * | P=0.058 |
|FISHER EXACT | P=0.001 ** P<0.001 ** P<0.001 ** | P=0.119 P=0.001 ** P=0.014 * |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 35/60 (58%) 46/59 (78%) 51/60 (85%) | 0/60 (0%) 17/59 (29%) 42/60 (70%) 27/60 (45%) |
|ADJUSTED (b) | 0.0% 80.8% 100.0% 100.0% | 0.0% 47.3% 100.0% 100.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 2/10 (20%) 4/10 (40%) 8/8 (100%) | 0/10 (0%) 1/10 (10%) 5/8 (63%) 8/8 (100%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 9/9 (100%) | |
|TERMINAL (d) | 0/34 (0%) 24/32 (75%) 14/14 (100%) 0/0 | 0/31 (0%) 12/30 (40%) 8/8 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 450 (I) 404 368 | --- 463 (I) 451 325 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 31/60 (52%) 36/59 (61%) 46/60 (77%) | 0/60 (0%) 14/59 (24%) 37/60 (62%) 24/60 (40%) |
|ADJUSTED (b) | 0.0% 74.8% 89.0% 97.7% | 0.0% 39.6% 100.0% 95.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 2/10 (20%) 3/10 (30%) 8/8 (100%) | 0/10 (0%) 1/10 (10%) 5/8 (63%) 7/8 (88%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 8/9 (89%) | |
|TERMINAL (d) | 0/34 (0%) 22/32 (69%) 10/14 (71%) 0/0 | 0/31 (0%) 10/30 (33%) 8/8 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 450 (I) 404 368 | --- 463 (I) 451 325 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 55/60 (92%) 54/60 (90%) 55/59 (93%) 52/60 (87%) | |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | |
|INTERIM SACRIFICE 1 (c)| 8/10 (80%) 6/10 (60%) 10/10 (100%) 8/8 (100%) | |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 9/9 (100%) | |
|TERMINAL (d) | 34/34 (100%) 32/32 (100%) 14/14 (100%) 0/0 | |
|FIRST INCIDENCE (DAYS) | 450 (I) 450 (I) 404 361 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.566N P<0.001 ** P<0.001 ** | |
|INCIDENTAL TUMOR | P=0.018 * P=0.240N P=0.037 * P=0.087 | |
|LOGISTIC REGRESSION | P=0.016 * P=0.339N P=0.151 P=0.065 | |
|COCHRAN-ARMITAGE | P=0.223N | |
|FISHER EXACT | P=0.500N P=0.511 P=0.279N | |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 15/59 (25%) 4/59 (7%) 6/60 (10%) | 4/60 (7%) 5/57 (9%) 4/60 (7%) 0/60 (0%) |
|ADJUSTED (b) | 10.9% 41.6% 22.5% 35.7% | 11.6% 12.9% 14.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/8 (13%) | 0/10 (0%) 1/10 (10%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 2/9 (22%) | |
|TERMINAL (d) | 3/34 (9%) 11/31 (35%) 2/14 (14%) 0/0 | 3/31 (10%) 1/30 (3%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 614 621 685 452 (I) | 526 465 (I) 513 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.005 ** P=0.253 P=0.012 * | P=0.542 P=0.492 P=0.243 (e) |
|INCIDENTAL TUMOR | P=0.163 P=0.006 ** P=0.478 P=0.373 | P=0.097N P=0.460 P=0.509N P=0.140N |
|LOGISTIC REGRESSION | P=0.043 * P=0.006 ** P=0.443 P=0.120 | P=0.357N P=0.472 P=0.569 P=0.676N |
|COCHRAN-ARMITAGE | P=0.261N | P=0.032N* |
|FISHER EXACT | P=0.005 ** P=0.632 P=0.372 | P=0.467 P=0.641N P=0.059N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/59 (2%) 2/59 (3%) 0/60 (0%) | 0/60 (0%) 1/57 (2%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 2.7% 11.8% 0.0% | 0.0% 3.3% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 0/34 (0%) 0/31 (0%) 1/14 (7%) 0/0 | 0/31 (0%) 1/30 (3%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 692 686 --- | --- 736 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.297 P=0.511 P=0.101 (e) | P=0.999 P=0.493 (e) (e) |
|INCIDENTAL TUMOR | P=0.621 P=0.674 P=0.241 (e) | P=0.999 P=0.493 (e) (e) |
|LOGISTIC REGRESSION | P=0.530 P=0.504 P=0.156 (e) | P=0.999 P=0.493 (e) (e) |
|COCHRAN-ARMITAGE | P=0.513N | P=0.572N |
|FISHER EXACT | P=0.496 P=0.244 (e) | P=0.487 (e) (e) |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 25
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 16/59 (27%) 6/59 (10%) 6/60 (10%) | 4/60 (7%) 6/57 (11%) 4/60 (7%) 0/60 (0%) |
|ADJUSTED (b) | 10.9% 43.1% 32.5% 35.7% | 11.6% 15.9% 14.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/8 (13%) | 0/10 (0%) 1/10 (10%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 2/9 (22%) | |
|TERMINAL (d) | 3/34 (9%) 11/31 (35%) 3/14 (21%) 0/0 | 3/31 (10%) 2/30 (7%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 614 621 685 452 (I) | 526 465 (I) 513 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.003 ** P=0.062 P=0.012 * | P=0.529 P=0.365 P=0.243 (e) |
|INCIDENTAL TUMOR | P=0.103 P=0.005 ** P=0.229 P=0.373 | P=0.103N P=0.335 P=0.509N P=0.140N |
|LOGISTIC REGRESSION | P=0.026 * P=0.003 ** P=0.171 P=0.120 | P=0.183N P=0.345 P=0.569 P=0.676N |
|COCHRAN-ARMITAGE | P=0.222N | P=0.024N* |
|FISHER EXACT | P=0.003 ** P=0.361 P=0.372 | P=0.339 P=0.641N P=0.059N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/59 (2%) 2/59 (3%) 2/60 (3%) | 0/60 (0%) 0/57 (0%) 3/60 (5%) 2/60 (3%) |
|ADJUSTED (b) | 2.9% 3.2% 8.5% 5.6% | 0.0% 0.0% 20.1% 8.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 1/34 (3%) 1/31 (3%) 0/14 (0%) 0/0 | 0/31 (0%) 0/30 (0%) 1/8 (13%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 678 425 | --- --- 538 310 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.007 ** P=0.741 P=0.308 P=0.160 | P<0.001 ** (e) P=0.026 * P=0.099 |
|INCIDENTAL TUMOR | P=0.370 P=0.741 P=0.677 P=0.913 | P=0.377 (e) P=0.093 P=0.860 |
|LOGISTIC REGRESSION | P=0.196 P=0.741 P=0.394 P=0.561 | P=0.151 (e) P=0.078 P=0.609 |
|COCHRAN-ARMITAGE | P=0.385 | P=0.160 |
|FISHER EXACT | P=0.748 P=0.494 P=0.500 | (e) P=0.122 P=0.248 |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 26
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/59 (2%) 3/59 (5%) 2/60 (3%) | 0/60 (0%) 1/57 (2%) 3/60 (5%) 2/60 (3%) |
|ADJUSTED (b) | 2.9% 3.2% 15.1% 5.6% | 0.0% 3.3% 20.1% 8.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 1/34 (3%) 1/31 (3%) 1/14 (7%) 0/0 | 0/31 (0%) 1/30 (3%) 1/8 (13%) 0/0 |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 678 425 | --- 736 (T) 538 310 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002 ** P=0.741 P=0.116 P=0.160 | P<0.001 ** P=0.493 P=0.026 * P=0.099 |
|INCIDENTAL TUMOR | P=0.218 P=0.741 P=0.333 P=0.913 | P=0.367 P=0.493 P=0.093 P=0.860 |
|LOGISTIC REGRESSION | P=0.120 P=0.741 P=0.185 P=0.561 | P=0.137 P=0.493 P=0.078 P=0.609 |
|COCHRAN-ARMITAGE | P=0.403 | P=0.264 |
|FISHER EXACT | P=0.748 P=0.303 P=0.500 | P=0.487 P=0.122 P=0.248 |
|=================================================================================================================================|
| |
|Tongue |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/59 (0%) 19/60 (32%) | 0/60 (0%) 0/59 (0%) 13/60 (22%) 8/60 (13%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 57.5% | 0.0% 0.0% 57.0% 34.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 1/8 (13%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 1/9 (11%) | |
|TERMINAL (d) | 0/34 (0%) 0/32 (0%) 0/14 (0%) 0/0 | 0/31 (0%) 0/30 (0%) 3/8 (38%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- 327 | --- --- 513 294 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** (e) (e) P<0.001 ** | P<0.001 ** (e) P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.005 ** (e) (e) P=0.245 | P=0.058 (e) P<0.001 ** P=0.273 |
|LOGISTIC REGRESSION | P<0.001 ** (e) (e) P=0.004 ** | P=0.011 * (e) P<0.001 ** P=0.100 |
|COCHRAN-ARMITAGE | P<0.001 ** | P=0.005 ** |
|FISHER EXACT | (e) (e) P<0.001 ** | (e) P<0.001 ** P=0.003 ** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 27
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Tongue |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 9/59 (15%) 40/60 (67%) | 0/60 (0%) 3/59 (5%) 18/60 (30%) 26/60 (43%) |
|ADJUSTED (b) | 0.0% 5.9% 36.7% 83.4% | 0.0% 9.1% 77.1% 78.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 3/8 (38%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 3/8 (38%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 3/9 (33%) | |
|TERMINAL (d) | 0/34 (0%) 1/32 (3%) 3/14 (21%) 0/0 | 0/31 (0%) 2/30 (7%) 5/8 (63%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 694 452 (I) 327 | --- 677 479 233 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.236 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.124 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.324 P=0.005 ** P=0.002 ** | P<0.001 ** P=0.130 P<0.001 ** P=0.005 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.248 P=0.001 ** P<0.001 ** | P<0.001 ** P=0.123 P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.248 P=0.001 ** P<0.001 ** | P=0.119 P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|Tongue |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 9/59 (15%) 21/60 (35%) | 0/60 (0%) 3/59 (5%) 5/60 (8%) 18/60 (30%) |
|ADJUSTED (b) | 0.0% 5.9% 36.7% 59.3% | 0.0% 9.1% 33.4% 65.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 3/8 (38%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 2/8 (25%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 2/9 (22%) | |
|TERMINAL (d) | 0/34 (0%) 1/32 (3%) 3/14 (21%) 0/0 | 0/31 (0%) 2/30 (7%) 2/8 (25%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- 694 452 (I) 337 | --- 677 479 233 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.236 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.124 P=0.002 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.324 P=0.005 ** P=0.030 * | P<0.001 ** P=0.130 P=0.017 * P=0.027 * |
|LOGISTIC REGRESSION | P<0.001 ** P=0.248 P=0.001 ** P<0.001 ** | P<0.001 ** P=0.123 P=0.017 * P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.248 P=0.001 ** P<0.001 ** | P=0.119 P=0.029 * P<0.001 ** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 28
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/60 (0%) 1/59 (2%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | | 0.0% 3.2% 25.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| | |
|TERMINAL (d) | | 0/31 (0%) 0/30 (0%) 2/8 (25%) 0/0 |
|FIRST INCIDENCE (DAYS) | | --- 729 736 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.144 P=0.500 P=0.027 * (e) |
|INCIDENTAL TUMOR | | P=0.259 P=0.540 P=0.027 * (e) |
|LOGISTIC REGRESSION | | P=0.186 P=0.506 P=0.027 * (e) |
|COCHRAN-ARMITAGE | | P=0.513N |
|FISHER EXACT | | P=0.496 P=0.248 (e) |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 9/60 (15%) 5/59 (8%) 7/60 (12%) 1/60 (2%) |
|ADJUSTED (b) | | 26.4% 13.7% 36.0% 11.1% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 1/10 (10%) 0/8 (0%) 1/8 (13%) |
|INTERIM SACRIFICE 2 (c)| | |
|TERMINAL (d) | | 7/31 (23%) 3/30 (10%) 2/8 (25%) 0/0 |
|FIRST INCIDENCE (DAYS) | | 547 463 (I) 450 463 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.126 P=0.207N P=0.143 P=0.455 |
|INCIDENTAL TUMOR | | P=0.611 P=0.220N P=0.612 P=0.455 |
|LOGISTIC REGRESSION | | P=0.435N P=0.192N P=0.581 P=0.751 |
|COCHRAN-ARMITAGE | | P=0.016N* |
|FISHER EXACT | | P=0.207N P=0.395N P=0.008N** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 29
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 3/60 (5%) 0/59 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | | 6.8% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| | |
|TERMINAL (d) | | 0/31 (0%) 0/30 (0%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | | 424 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.407N P=0.116N P=0.233N P=0.786N |
|INCIDENTAL TUMOR | | P=0.094N P=0.086N P=0.053N P=0.140N |
|LOGISTIC REGRESSION | | P=0.073N P=0.127N P=0.087N P=0.143N |
|COCHRAN-ARMITAGE | | P=0.134N |
|FISHER EXACT | | P=0.125N P=0.122N P=0.122N |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 12/60 (20%) 5/59 (8%) 7/60 (12%) 1/60 (2%) |
|ADJUSTED (b) | | 31.4% 13.7% 36.0% 11.1% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 1/10 (10%) 0/8 (0%) 1/8 (13%) |
|INTERIM SACRIFICE 2 (c)| | |
|TERMINAL (d) | | 7/31 (23%) 3/30 (10%) 2/8 (25%) 0/0 |
|FIRST INCIDENCE (DAYS) | | 424 463 (I) 450 463 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.289 P=0.065N P=0.355 P=0.584 |
|INCIDENTAL TUMOR | | P=0.303N P=0.058N P=0.236N P=0.623N |
|LOGISTIC REGRESSION | | P=0.134N P=0.059N P=0.293N P=0.344N |
|COCHRAN-ARMITAGE | | P=0.005N** |
|FISHER EXACT | | P=0.061N P=0.159N P=0.001N** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 30
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/59 (0%) 3/60 (5%) | 0/60 (0%) 1/59 (2%) 0/60 (0%) 4/60 (7%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 6.0% | 0.0% 2.9% 0.0% 36.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 1/8 (13%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 0/34 (0%) 0/32 (0%) 0/14 (0%) 0/0 | 0/31 (0%) 0/30 (0%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- 395 | --- 713 --- 336 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.005 ** (e) (e) P=0.093 | P<0.001 ** P=0.506 (e) P=0.003 ** |
|INCIDENTAL TUMOR | P=0.376 (e) (e) P=0.840 | P=0.063 P=0.540 (e) P=0.319 |
|LOGISTIC REGRESSION | P=0.058 (e) (e) P=0.441 | P=0.028 * P=0.503 (e) P=0.103 |
|COCHRAN-ARMITAGE | P=0.009 ** | P=0.011 * |
|FISHER EXACT | (e) (e) P=0.122 | P=0.496 (e) P=0.059 |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/59 (0%) 2/60 (3%) | 0/60 (0%) 1/59 (2%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 9.0% | 0.0% 3.3% 0.0% 3.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 0/34 (0%) 0/32 (0%) 0/14 (0%) 0/0 | 0/31 (0%) 1/30 (3%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- 485 | --- 736 (T) --- 371 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.005 ** (e) (e) P=0.090 | P=0.120 P=0.493 (e) P=0.375 |
|INCIDENTAL TUMOR | P=0.500 (e) (e) P=0.913 | P=0.447 P=0.493 (e) P=0.860 |
|LOGISTIC REGRESSION | P=0.111 (e) (e) P=0.394 | P=0.481 P=0.493 (e) P=0.842 |
|COCHRAN-ARMITAGE | P=0.042 * | P=0.466 |
|FISHER EXACT | (e) (e) P=0.248 | P=0.496 (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 31
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/59 (0%) 2/60 (3%) | 0/60 (0%) 1/59 (2%) 1/60 (2%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 9.0% | 0.0% 3.3% 8.3% 3.1% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 0/34 (0%) 0/32 (0%) 0/14 (0%) 0/0 | 0/31 (0%) 1/30 (3%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | --- --- --- 485 | --- 736 (T) 709 371 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.005 ** (e) (e) P=0.090 | P=0.038 * P=0.493 P=0.299 P=0.375 |
|INCIDENTAL TUMOR | P=0.500 (e) (e) P=0.913 | P=0.284 P=0.493 P=0.500 P=0.860 |
|LOGISTIC REGRESSION | P=0.111 (e) (e) P=0.394 | P=0.268 P=0.493 P=0.362 P=0.842 |
|COCHRAN-ARMITAGE | P=0.042 * | P=0.487 |
|FISHER EXACT | (e) (e) P=0.248 | P=0.496 P=0.500 P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 16/60 (27%) 11/60 (18%) 9/59 (15%) 6/60 (10%) | 13/60 (22%) 17/59 (29%) 14/60 (23%) 0/60 (0%) |
|ADJUSTED (b) | 42.6% 30.5% 42.0% 34.6% | 34.9% 44.1% 69.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 1/9 (11%) | |
|TERMINAL (d) | 13/34 (38%) 8/32 (25%) 4/14 (29%) 0/0 | 8/31 (26%) 10/30 (33%) 4/8 (50%) 0/0 |
|FIRST INCIDENCE (DAYS) | 605 591 590 459 | 597 434 405 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.216N P=0.459 P=0.001 ** | P=0.025 * P=0.265 P=0.005 ** (e) |
|INCIDENTAL TUMOR | P=0.410 P=0.171N P=0.375N P=0.719 | P=0.104N P=0.233 P=0.330 (e) |
|LOGISTIC REGRESSION | P=0.152 P=0.141N P=0.311N P=0.219 | P=0.323N P=0.262 P=0.164 P=0.372N |
|COCHRAN-ARMITAGE | P=0.022N* | P<0.001N** |
|FISHER EXACT | P=0.191N P=0.096N P=0.016N* | P=0.246 P=0.500 P<0.001N** |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 32
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 4/60 (7%) 4/59 (7%) 2/60 (3%) | 0/60 (0%) 0/59 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 7.8% 10.4% 18.1% 10.6% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/8 (0%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/8 (0%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 0/9 (0%) | |
|TERMINAL (d) | 2/34 (6%) 1/32 (3%) 2/14 (14%) 0/0 | 0/31 (0%) 0/30 (0%) 0/8 (0%) 0/0 |
|FIRST INCIDENCE (DAYS) | 485 621 450 (I) 493 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.034 * P=0.505 P=0.228 P=0.217 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.546N P=0.430 P=0.315 P=0.160N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.606N P=0.509 P=0.469 P=0.732N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.332N | (e) |
|FISHER EXACT | P=0.500 P=0.491 P=0.500N | (e) (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 57/60 (95%) 58/60 (97%) 56/59 (95%) 57/60 (95%) | 42/60 (70%) 48/59 (81%) 51/60 (85%) 40/60 (67%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 93.2% 100.0% 100.0% 100.0% |
|INTERIM SACRIFICE 1 (c)| 8/10 (80%) 8/10 (80%) 10/10 (100%) 8/8 (100%) | 1/10 (10%) 4/10 (40%) 5/8 (63%) 8/8 (100%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 9/9 (100%) | |
|TERMINAL (d) | 34/34 (100%) 32/32 (100%) 14/14 (100%) 0/0 | 28/31 (90%) 30/30 (100%) 8/8 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | 340 450 (I) 404 337 | 463 (I) 463 (I) 405 233 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.445 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.164 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.036 * P=0.707 P=0.304 P=0.130 | P<0.001 ** P=0.071 P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION | P=0.026 * P=0.656 P=0.268 P=0.072 | P<0.001 ** P=0.073 P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.524N | P=0.129N |
|FISHER EXACT | P=0.500 P=0.652N P=0.660N | P=0.109 P=0.040 * P=0.422N |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 33
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG | 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 22/60 (37%) 28/60 (47%) 40/59 (68%) 47/60 (78%) | 20/60 (33%) 25/59 (42%) 46/60 (77%) 48/60 (80%) |
|ADJUSTED (b) | 54.1% 60.5% 97.3% 93.6% | 47.2% 62.9% 100.0% 94.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 2/10 (20%) 2/8 (25%) | 0/10 (0%) 0/10 (0%) 0/8 (0%) 5/8 (63%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 6/9 (67%) | |
|TERMINAL (d) | 16/34 (47%) 14/32 (44%) 13/14 (93%) 0/0 | 10/31 (32%) 16/30 (53%) 8/8 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | 485 591 404 327 | 424 434 255 184 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.199 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.236 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.270 P<0.001 ** P=0.026 * | P<0.001 ** P=0.224 P<0.001 ** P=0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.247 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.216 P<0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** |
|FISHER EXACT | P=0.177 P<0.001 ** P<0.001 ** | P=0.204 P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 58/60 (97%) 58/60 (97%) 57/59 (97%) 60/60 (100%)| 49/60 (82%) 50/59 (85%) 56/60 (93%) 56/60 (93%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 98.0% 100.0% 100.0% 100.0% |
|INTERIM SACRIFICE 1 (c)| 8/10 (80%) 8/10 (80%) 10/10 (100%) 8/8 (100%) | 1/10 (10%) 4/10 (40%) 5/8 (63%) 8/8 (100%) |
|INTERIM SACRIFICE 2 (c)| 0/0 0/0 0/0 9/9 (100%) | |
|TERMINAL (d) | 34/34 (100%) 32/32 (100%) 14/14 (100%) 0/0 | 30/31 (97%) 30/30 (100%) 8/8 (100%) 0/0 |
|FIRST INCIDENCE (DAYS) | 340 450 (I) 404 327 | 424 434 255 184 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001 ** P=0.512 P<0.001 ** P<0.001 ** | P<0.001 ** P=0.455 P<0.001 ** P<0.001 ** |
|INCIDENTAL TUMOR | P=0.066 P=0.707 P=0.579 P=0.284 | P<0.001 ** P=0.428 P=0.019 * P<0.001 ** |
|LOGISTIC REGRESSION | P=0.005 ** P=0.566N P=0.264 P=0.036 * | P<0.001 ** P=0.436 P=0.001 ** P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.157 | P=0.036 * |
|FISHER EXACT | P=0.691N P=0.684N P=0.248 | P=0.420 P=0.048 * P=0.048 * |
|=================================================================================================================================|
DATE: 09/14/94 EXPERIMENT: 05111 TEST: 01 PAGE 34
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 1,2,3-TRICHLOROPROPANE
MALE TERMINAL SACRIFICE AT 105 WEEKS
FEMALE TERMINAL SACRIFICE AT 106 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 450 534
Female interim sacrifices(days): 463
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).
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