TDMS Study 05111-01 Pathology Tables
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
Facility: TSI Mason Research
Chemical CAS #: 96-18-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 4| 3| 4| 3| 3| 4| 3| 3| 0| 0| 3| 3| 4| 4| 6| 3| 3| 1| 9| 6| 3| 3| 3| 3| 6|
| 1| 8| 1| 8| 8| 1| 8| 8| 8| 1| 8| 8| 5| 7| 3| 8| 8| 4| 7| 5| 8| 8| 8| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M + + + + + + + + + M + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X |
Eosinophilic Focus | X |
Fatty Change, Diffuse | 2 |
Fatty Change, Focal | |
Hepatodiaphragmatic Nodule | X |
Hepatodiaphragmatic Nodule, Multiple | |
Hyperplasia | 2 |
Inflammation, Granulomatous | 2 2 1 1 1 |
Mixed Cell Focus | X X X |
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic Active | 2 |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 3 2 1 1 1 |
Acinus, Hyperplasia | 1 3 2 |
__________________________________________________________________________|
Pharynx | + |
Palate, Hyperplasia, Basal Cell | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
Inflammation, Chronic Active | 2 |
Ulcer | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 4| 3| 4| 3| 3| 4| 3| 3| 0| 0| 3| 3| 4| 4| 6| 3| 3| 1| 9| 6| 3| 3| 3| 3| 6|
| 1| 8| 1| 8| 8| 1| 8| 8| 8| 1| 8| 8| 5| 7| 3| 8| 8| 4| 7| 5| 8| 8| 8| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 3 2 2 2 2 2 3 |
Pars Distalis, Cyst | X X X X X |
Pars Distalis, Hyperplasia | 2 2 2 3 2 2 2 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 |
Follicle, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + M + + + + + M + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic Active | |
Endometrium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation | |
Pancreatic, Pigmentation | 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 1 2 1 1 1 1 2 2 1 1 1 |
Infiltration Cellular, Histiocyte | 3 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + M + + + + + + + + +|
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 7| 7| 5| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 4| 3| 4| 3| 3| 4| 3| 3| 0| 0| 3| 3| 4| 4| 6| 3| 3| 1| 9| 6| 3| 3| 3| 3| 6|
| 1| 8| 1| 8| 8| 1| 8| 8| 8| 1| 8| 8| 5| 7| 3| 8| 8| 4| 7| 5| 8| 8| 8| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + M + + + + + + + + M + + + + + + + + + + + + +|
Galactocele | X X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 1 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Fibrosis | |
Infiltration Cellular, Histiocyte | 1 1 |
Inflammation, Acute | |
Alveolar Epithelium, Hyperplasia | 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
Hemorrhage | 4 |
Synechia | 1 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Nephropathy | 1 1 1 1 1 2 2 1 1 |
Cortex, Mineralization | |
Papilla, Mineralization | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 4| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 4| 2| 4| 4| 4| 7| 5| 4| 4| 6| 6| 5| 4| 4| 2| 6| 6| 3| 3| 4| 1| 2|
| 8| 8| 8| 7| 6| 2| 2| 1| 0| 2| 2| 2| 5| 3| 0| 2| 2| 6| 5| 3| 8| 8| 1| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X |
Eosinophilic Focus | |
Fatty Change, Diffuse | |
Fatty Change, Focal | 2 1 1 |
Hepatodiaphragmatic Nodule | X |
Hepatodiaphragmatic Nodule, Multiple | X |
Hyperplasia | |
Inflammation, Granulomatous | 2 |
Mixed Cell Focus | |
__________________________________________________________________________|
Mesentery | |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 2 1 |
Acinus, Hyperplasia | 1 |
__________________________________________________________________________|
Pharynx | |
Palate, Hyperplasia, Basal Cell | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 4| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 4| 2| 4| 4| 4| 7| 5| 4| 4| 6| 6| 5| 4| 4| 2| 6| 6| 3| 3| 4| 1| 2|
| 8| 8| 8| 7| 6| 2| 2| 1| 0| 2| 2| 2| 5| 3| 0| 2| 2| 6| 5| 3| 8| 8| 1| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + M + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 2 1 2 |
Pars Distalis, Cyst | X X X X X X |
Pars Distalis, Hyperplasia | 2 1 2 2 1 2 2 2 2 1 3 2 2 2 |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 |
Follicle, Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic Active | 3 |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation | 2 2 |
Pancreatic, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 1 3 3 2 2 3 3 1 1 2|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Thymus | + M + + M + + + + + + + + + + + + + + + + + + + +|
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 4| 4| 4| 7| 7| 6| 4| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 4| 2| 4| 4| 4| 7| 5| 4| 4| 6| 6| 5| 4| 4| 2| 6| 6| 3| 3| 4| 1| 2|
| 8| 8| 8| 7| 6| 2| 2| 1| 0| 2| 2| 2| 5| 3| 0| 2| 2| 6| 5| 3| 8| 8| 1| 7| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 MG/KG | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Galactocele | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Hyperkeratosis | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Fibrosis | 2 |
Infiltration Cellular, Histiocyte | 1 1 |
Inflammation, Acute | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
Hemorrhage | |
Synechia | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 1 1 1 1 1 1|
Cortex, Mineralization | 1 |
Papilla, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 4| 4| 5| 7| 5| 4| 4| | |
DAY ON TEST | 4| 9| 8| 6| 6| 5| 4| 5| 7| 6| | |
| 1| 9| 3| 3| 3| 0| 0| 0| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
Hyperkeratosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X X X X X | 23 |
Eosinophilic Focus | | 1 |
Fatty Change, Diffuse | | 1 2.0|
Fatty Change, Focal | | 3 1.3|
Hepatodiaphragmatic Nodule | | 2 |
Hepatodiaphragmatic Nodule, Multiple | | 1 |
Hyperplasia | 1 | 2 1.5|
Inflammation, Granulomatous | | 6 1.5|
Mixed Cell Focus | X | 4 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Inflammation, Chronic Active | | 1 2.0|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | | 10 1.4|
Acinus, Hyperplasia | 1 | 5 1.6|
__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Hyperplasia, Basal Cell | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperplasia, Squamous | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Tongue | + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 4| 4| 5| 7| 5| 4| 4| | |
DAY ON TEST | 4| 9| 8| 6| 6| 5| 4| 5| 7| 6| | |
| 1| 9| 3| 3| 3| 0| 0| 0| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 2 2 | 18 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
Hyperplasia | | 7 1.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + M | 54 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | 2 3 3 2 | 19 2.2|
Pars Distalis, Cyst | X | 12 |
Pars Distalis, Hyperplasia | 2 1 2 | 24 1.9|
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | 1 1 | 7 1.1|
Follicle, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | | 4 |
__________________________________________________________________________|____________|
Oviduct | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Cyst | | 2 |
Inflammation, Chronic Active | | 1 3.0|
Endometrium, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 5 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Pigmentation | 2 | 3 2.0|
Pancreatic, Pigmentation | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 4| 4| 5| 7| 5| 4| 4| | |
DAY ON TEST | 4| 9| 8| 6| 6| 5| 4| 5| 7| 6| | |
| 1| 9| 3| 3| 3| 0| 0| 0| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Angiectasis | | 4 1.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Fibrosis | 2 | 3 2.3|
Hematopoietic Cell Proliferation | 1 2 2 | 25 1.7|
Infiltration Cellular, Histiocyte | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
Epithelial Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 57 |
Galactocele | | 11 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Acanthosis | | 1 2.0|
Hyperkeratosis | | 1 1.0|
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Hemorrhage | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
Fibrosis | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 | 5 1.0|
Inflammation, Acute | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Acute | | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 4| 4| 5| 7| 5| 4| 4| | |
DAY ON TEST | 4| 9| 8| 6| 6| 5| 4| 5| 7| 6| | |
| 1| 9| 3| 3| 3| 0| 0| 0| 4| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Hemorrhage | | 1 4.0|
Synechia | | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 1 |
Nephropathy | 1 1 1 | 18 1.1|
Cortex, Mineralization | | 1 1.0|
Papilla, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 1| 4| 6| 3| 3| 3| 8| 6| 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 0| 6| 6|
| 7| 7| 3| 5| 3| 7| 6| 6| 0| 3| 7| 7| 9| 5| 0| 7| 6| 6| 6| 5| 6| 7| 8| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
3 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + A + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + A + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + A + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X |
Clear Cell Focus | X |
Eosinophilic Focus | X X|
Fatty Change, Focal | |
Hepatodiaphragmatic Nodule | |
Hyperplasia | |
Inflammation, Granulomatous | 1 |
Mixed Cell Focus | X X |
Necrosis | 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 |
Acinus, Hyperplasia | 2 1 1 1 2 1 1 |
__________________________________________________________________________|
Pharynx | + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | 2 2 1 1 1 2 1 1 |
Hyperplasia, Squamous | 2 2 2 2 2 2 2 2 2 3 1 |
Inflammation, Chronic Active | 1 |
Mineralization | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Tongue | + + |
Hyperplasia, Squamous | 3 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 1| 4| 6| 3| 3| 3| 8| 6| 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 0| 6| 6|
| 7| 7| 3| 5| 3| 7| 6| 6| 0| 3| 7| 7| 9| 5| 0| 7| 6| 6| 6| 5| 6| 7| 8| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
3 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +|
Metaplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + A + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 2 3 3 3 2 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia | 2 2 1 2 2 2 2 1 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + A + + + + +|
C-Cell, Hyperplasia | 2 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | |
Endometrium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +|
Angiectasis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 1 2 2 2 1 2 1 2 1 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 7| 5| 4| 7| 7| 7| 4| 4| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 1| 4| 6| 3| 3| 3| 8| 6| 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 0| 6| 6|
| 7| 7| 3| 5| 3| 7| 6| 6| 0| 3| 7| 7| 9| 5| 0| 7| 6| 6| 6| 5| 6| 7| 8| 4| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
3 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Galactocele | X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Infiltration Cellular, Histiocyte | 1 1 |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Synechia | 2 |
Lens, Cataract | |
Retina, Atrophy | 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + A + + + + A + + + + +|
Infarct | |
Nephropathy | 1 1 1 1 1 2 1 1 |
Cortex, Mineralization | |
Papilla, Mineralization | |
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 4| 4| 4| 7| 6| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 9| 6| 6| 3| 3| 7| 3| 3| 6| 3| 3| 9| 7| 6| 3| 3| 3| 0| 6|
| 7| 7| 7| 6| 6| 5| 0| 5| 3| 4| 8| 0| 7| 7| 3| 7| 7| 6| 7| 5| 8| 8| 7| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
3 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X|
Clear Cell Focus | |
Eosinophilic Focus | |
Fatty Change, Focal | 2 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | 2 2 2 |
Inflammation, Granulomatous | 1 1 2 2 |
Mixed Cell Focus | X X X X |
Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 1 1 2 |
Acinus, Hyperplasia | 2 1 1 1 1 1 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 1 1 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | 2 1 |
Hyperplasia, Squamous | 1 2 1 3 1 2 2 2 1 2 3 2 1|
Inflammation, Chronic Active | |
Mineralization | 1 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
__________________________________________________________________________|
Tongue | + + |
Hyperplasia, Squamous | |
Inflammation, Acute | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 3 3 2 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 4| 4| 4| 7| 6| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 9| 6| 6| 3| 3| 7| 3| 3| 6| 3| 3| 9| 7| 6| 3| 3| 3| 0| 6|
| 7| 7| 7| 6| 6| 5| 0| 5| 3| 4| 8| 0| 7| 7| 3| 7| 7| 6| 7| 5| 8| 8| 7| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
3 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Artery, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M M + + + + + + + + + + + + + + + + + + + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 2 2 2 2 3 2 2 |
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 1 2 1 2 2 2 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | X |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation | 2 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 1 1 2 1 2 2 1 3 3|
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 4| 4| 4| 7| 6| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 2| 9| 6| 6| 3| 3| 7| 3| 3| 6| 3| 3| 9| 7| 6| 3| 3| 3| 0| 6|
| 7| 7| 7| 6| 6| 5| 0| 5| 3| 4| 8| 0| 7| 7| 3| 7| 7| 6| 7| 5| 8| 8| 7| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
3 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + M + + + + + + + + + + + + + + + + +|
Galactocele | X X X X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Infiltration Cellular, Histiocyte | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + +|
Synechia | |
Lens, Cataract | 3 |
Retina, Atrophy | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 2 |
Nephropathy | 1 1 1 1 1 1 1 3 1 1 3 |
Cortex, Mineralization | |
Papilla, Mineralization | 2 |
Renal Tubule, Hyperplasia | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 7| 5| 0| | |
DAY ON TEST | 3| 1| 1| 6| 6| 3| 3| 3| 8| 0| | |
| 7| 3| 0| 5| 5| 8| 8| 8| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
3 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 59 |
Basophilic Focus | X X X X X X X | 29 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | | 2 |
Fatty Change, Focal | 2 | 2 2.0|
Hepatodiaphragmatic Nodule | X X | 3 |
Hyperplasia | | 3 2.0|
Inflammation, Granulomatous | | 5 1.4|
Mixed Cell Focus | | 6 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 5 |
Fat, Necrosis | | 4 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 59 |
Acinus, Atrophy | 1 | 9 1.3|
Acinus, Hyperplasia | 1 2 | 15 1.3|
__________________________________________________________________________|____________|
Pharynx | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 59 |
Duct, Metaplasia, Squamous | | 5 1.2|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 59 |
Hyperplasia, Basal Cell | | 10 1.4|
Hyperplasia, Squamous | 2 2 | 26 1.9|
Inflammation, Chronic Active | | 1 1.0|
Mineralization | 1 | 2 1.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 59 |
Mineralization | 1 | 2 1.0|
__________________________________________________________________________|____________|
Tongue | | 4 |
Hyperplasia, Squamous | | 1 3.0|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 7| 5| 0| | |
DAY ON TEST | 3| 1| 1| 6| 6| 3| 3| 3| 8| 0| | |
| 7| 3| 0| 5| 5| 8| 8| 8| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
3 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 59 |
Cardiomyopathy | 2 | 22 2.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + M + + + + + + + | 58 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + M + + + + + + + | 58 |
Degeneration, Fatty | 3 | 2 2.5|
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + + + + M + | 56 |
Hyperplasia | | 5 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 58 |
Metaplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 58 |
Pars Distalis, Angiectasis | 2 3 2 | 21 2.3|
Pars Distalis, Cyst | X X | 7 |
Pars Distalis, Hyperplasia | 2 2 1 | 22 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 57 |
C-Cell, Hyperplasia | 2 1 1 1 | 7 1.3|
Follicular Cell, Hyperplasia | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + + + | 56 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 58 |
Cyst | X | 3 |
__________________________________________________________________________|____________|
Oviduct | + + + + + + + + | 42 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 58 |
Decidual Reaction | | 1 |
Endometrium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 7| 5| 0| | |
DAY ON TEST | 3| 1| 1| 6| 6| 3| 3| 3| 8| 0| | |
| 7| 3| 0| 5| 5| 8| 8| 8| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
3 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Blood | | 4 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 59 |
Mediastinal, Pigmentation | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 58 |
Angiectasis | 1 | 2 2.0|
__________________________________________________________________________|____________|
Spleen | + + M + + + + + + | 57 |
Hematopoietic Cell Proliferation | 1 1 2 | 27 1.7|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + | 55 |
Galactocele | X X | 15 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 59 |
Acanthosis | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 59 |
Hyperostosis | | 1 3.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 59 |
Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 58 |
Fibrosis | | 1 1.0|
Infiltration Cellular, Histiocyte | | 2 1.0|
Alveolar Epithelium, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 59 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + | 5 |
Synechia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 4| 4| 7| 7| 7| 5| 0| | |
DAY ON TEST | 3| 1| 1| 6| 6| 3| 3| 3| 8| 0| | |
| 7| 3| 0| 5| 5| 8| 8| 8| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
3 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Lens, Cataract | | 1 3.0|
Retina, Atrophy | | 2 2.5|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 57 |
Infarct | | 1 2.0|
Nephropathy | 2 3 | 21 1.4|
Cortex, Mineralization | 1 | 1 1.0|
Papilla, Mineralization | | 1 2.0|
Renal Tubule, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 56 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 5| 5| 5| 5| 4| 6| 6| 5| 4| 4| 6| 5| 5| 2| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 2| 6| 3| 2| 1| 5| 8| 4| 1| 6| 3| 0| 8| 3| 5| 6| 3| 3| 0| 8| 2|
| 6| 7| 6| 6| 8| 3| 8| 0| 0| 0| 3| 2| 3| 5| 4| 8| 1| 8| 5| 3| 6| 6| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 2 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X|
Bile Stasis | |
Clear Cell Focus | |
Eosinophilic Focus | X X |
Fatty Change, Focal | 1 |
Fibrosis | 1|
Hepatodiaphragmatic Nodule | X X X X X X |
Hyperplasia | |
Mitotic Alteration | |
Mixed Cell Focus | X X X |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 2 1 1 |
Acinus, Hyperplasia | 1 1 3 1 2 1 2 2 |
__________________________________________________________________________|
Pharynx | + + + + + + |
Hyperplasia, Squamous | |
Palate, Abscess | |
Palate, Hyperplasia, Basal Cell | |
Palate, Hyperplasia, Squamous | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia, Basal Cell | 2 |
Hyperplasia, Squamous | 2 2 1 2 1 2 2 3 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + + + + + + + + + + |
Hyperkeratosis | |
Inflammation, Acute | 2 1 3 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 5| 5| 5| 5| 4| 6| 6| 5| 4| 4| 6| 5| 5| 2| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 2| 6| 3| 2| 1| 5| 8| 4| 1| 6| 3| 0| 8| 3| 5| 6| 3| 3| 0| 8| 2|
| 6| 7| 6| 6| 8| 3| 8| 0| 0| 0| 3| 2| 3| 5| 4| 8| 1| 8| 5| 3| 6| 6| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | |
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Metaplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M M + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Cyst | X X X X X |
Pars Distalis, Hyperplasia | 2 1 2 2 3 2 2 2 2 2 2|
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 1 2 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia | 1 1 |
Necrosis | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X|
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 5| 5| 5| 5| 4| 6| 6| 5| 4| 4| 6| 5| 5| 2| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 2| 6| 3| 2| 1| 5| 8| 4| 1| 6| 3| 0| 8| 3| 5| 6| 3| 3| 0| 8| 2|
| 6| 7| 6| 6| 8| 3| 8| 0| 0| 0| 3| 2| 3| 5| 4| 8| 1| 8| 5| 3| 6| 6| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3 2 2 2 2 2 2 3 2 2 3 3 2 3 2 2 3 3|
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +|
Epithelial Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + M + M + + + + M + + + + + + + + + +|
Galactocele | X X X X |
__________________________________________________________________________|
Skin | + + + + M + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 2 |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 1 1 2 |
Inflammation, Acute | 1 |
Alveolar Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
Inflammation, Acute | |
Synechia | 2 |
Lens, Cataract | 3 |
Retina, Atrophy | 3 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 5| 5| 5| 5| 4| 6| 6| 5| 4| 4| 6| 5| 5| 2| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 3| 3| 3| 3| 2| 6| 3| 2| 1| 5| 8| 4| 1| 6| 3| 0| 8| 3| 5| 6| 3| 3| 0| 8| 2|
| 6| 7| 6| 6| 8| 3| 8| 0| 0| 0| 3| 2| 3| 5| 4| 8| 1| 8| 5| 3| 6| 6| 5| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 4| 7| 7| 6| 4| 4| 6| 5| 4| 4| 4| 7| 7| 6| 4| 4| 7| 7| 6| 5| 5|
DAY ON TEST | 4| 2| 0| 5| 7| 2| 0| 9| 6| 6| 4| 6| 6| 6| 0| 3| 2| 1| 6| 0| 3| 0| 3| 1| 0|
| 1| 5| 4| 7| 9| 1| 9| 9| 3| 3| 3| 1| 3| 3| 5| 6| 5| 2| 5| 5| 8| 1| 4| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 2 2 2 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X |
Bile Stasis | 1 |
Clear Cell Focus | X |
Eosinophilic Focus | |
Fatty Change, Focal | |
Fibrosis | |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia | 2 |
Mitotic Alteration | |
Mixed Cell Focus | |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 |
Acinus, Hyperplasia | 3 2 2 1 1 2 2 2 2 1 1 1 |
__________________________________________________________________________|
Pharynx | + + + + + + + + |
Hyperplasia, Squamous | 2 |
Palate, Abscess | 2 |
Palate, Hyperplasia, Basal Cell | |
Palate, Hyperplasia, Squamous | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | 2 2 |
Hyperplasia, Squamous | 1 2 3 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + + + + + + + |
Hyperkeratosis | |
Inflammation, Acute | 1 2 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 4| 7| 7| 6| 4| 4| 6| 5| 4| 4| 4| 7| 7| 6| 4| 4| 7| 7| 6| 5| 5|
DAY ON TEST | 4| 2| 0| 5| 7| 2| 0| 9| 6| 6| 4| 6| 6| 6| 0| 3| 2| 1| 6| 0| 3| 0| 3| 1| 0|
| 1| 5| 4| 7| 9| 1| 9| 9| 3| 3| 3| 1| 3| 3| 5| 6| 5| 2| 5| 5| 8| 1| 4| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 2 |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | 3 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Metaplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + M + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 2 2 3 |
Pars Distalis, Cyst | X X X X X X |
Pars Distalis, Hyperplasia | 3 1 3 2 2 2 2 1 2 2 |
Pars Intermedia, Cyst | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Necrosis | 4 3 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 4| 7| 7| 6| 4| 4| 6| 5| 4| 4| 4| 7| 7| 6| 4| 4| 7| 7| 6| 5| 5|
DAY ON TEST | 4| 2| 0| 5| 7| 2| 0| 9| 6| 6| 4| 6| 6| 6| 0| 3| 2| 1| 6| 0| 3| 0| 3| 1| 0|
| 1| 5| 4| 7| 9| 1| 9| 9| 3| 3| 3| 1| 3| 3| 5| 6| 5| 2| 5| 5| 8| 1| 4| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 2 1 3 1 3 1 2 1 3 2 3 2 2 3|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + + + + + + + + + M + + + + + + + + + +|
Galactocele | X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 |
Inflammation, Acute | 3 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + + + |
Inflammation, Acute | 3 4 |
Synechia | 2 |
Lens, Cataract | 3 3 |
Retina, Atrophy | 2 3 4 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 4| 7| 7| 6| 4| 4| 6| 5| 4| 4| 4| 7| 7| 6| 4| 4| 7| 7| 6| 5| 5|
DAY ON TEST | 4| 2| 0| 5| 7| 2| 0| 9| 6| 6| 4| 6| 6| 6| 0| 3| 2| 1| 6| 0| 3| 0| 3| 1| 0|
| 1| 5| 4| 7| 9| 1| 9| 9| 3| 3| 3| 1| 3| 3| 5| 6| 5| 2| 5| 5| 8| 1| 4| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
10 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 6| 6| 5| 5| 4| | |
DAY ON TEST | 3| 0| 7| 9| 5| 7| 6| 5| 2| 6| | |
| 8| 8| 2| 8| 1| 6| 9| 0| 1| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
10 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Hyperkeratosis | 3 2 2 2 2 | 15 2.1|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + M | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Diverticulum | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X X X | 20 |
Bile Stasis | | 1 1.0|
Clear Cell Focus | X | 2 |
Eosinophilic Focus | | 2 |
Fatty Change, Focal | 1 | 2 1.0|
Fibrosis | | 1 1.0|
Hepatodiaphragmatic Nodule | X | 11 |
Hyperplasia | | 1 2.0|
Mitotic Alteration | 4 | 1 4.0|
Mixed Cell Focus | | 3 |
Bile Duct, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fat, Necrosis | | 3 2.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | 1 1 | 9 1.3|
Acinus, Hyperplasia | 1 1 2 3 | 24 1.7|
__________________________________________________________________________|____________|
Pharynx | + + + + | 18 |
Hyperplasia, Squamous | | 1 2.0|
Palate, Abscess | | 1 2.0|
Palate, Hyperplasia, Basal Cell | 2 | 1 2.0|
Palate, Hyperplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Duct, Metaplasia, Squamous | 1 | 3 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Hyperplasia, Basal Cell | 1 2 | 5 1.8|
Hyperplasia, Squamous | 3 3 1 | 15 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 6| 6| 5| 5| 4| | |
DAY ON TEST | 3| 0| 7| 9| 5| 7| 6| 5| 2| 6| | |
| 8| 8| 2| 8| 1| 6| 9| 0| 1| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
10 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Tongue | + + + + | 21 |
Hyperkeratosis | 2 | 1 2.0|
Inflammation, Acute | 2 | 6 1.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 2 2 | 17 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Degeneration, Fatty | | 1 2.0|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
Metaplasia | | 2 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Angiectasis | 2 2 2 | 11 2.1|
Pars Distalis, Cyst | | 11 |
Pars Distalis, Hyperplasia | 2 2 2 2 | 25 2.0|
Pars Intermedia, Cyst | | 3 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | 1 | 8 1.3|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + M + + + + + + + | 58 |
Hyperplasia | 2 | 3 1.3|
Necrosis | | 3 2.7|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 6| 6| 5| 5| 4| | |
DAY ON TEST | 3| 0| 7| 9| 5| 7| 6| 5| 2| 6| | |
| 8| 8| 2| 8| 1| 6| 9| 0| 1| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
10 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | | 8 |
__________________________________________________________________________|____________|
Oviduct | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Decidual Reaction | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 3 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Pigmentation | 2 | 5 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Degeneration | 2 | 4 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 2 2 2 2 3 | 40 2.3|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 59 |
Epithelial Cell, Hyperplasia | | 4 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + | 53 |
Galactocele | X | 11 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Hyperplasia, Reticulum Cell | | 1 2.0|
Inflammation, Acute | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 59 |
Infiltration Cellular, Histiocyte | | 5 1.4|
Inflammation, Acute | | 2 2.0|
Alveolar Epithelium, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 5| 4| 6| 6| 5| 5| 4| | |
DAY ON TEST | 3| 0| 7| 9| 5| 7| 6| 5| 2| 6| | |
| 8| 8| 2| 8| 1| 6| 9| 0| 1| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
10 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Acute | | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 11 |
Inflammation, Acute | | 2 3.5|
Synechia | | 2 2.0|
Lens, Cataract | | 3 3.0|
Retina, Atrophy | | 4 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy | 1 | 18 1.1|
Renal Tubule, Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 3| 3| 3| 0| 0| 4| 4| 3| 3| 3| 4| 4| 3| 3| 3| 4| 4| 4| 3| 2| 3| 3| 3| 3| 3|
DAY ON TEST | 8| 7| 5| 8| 8| 6| 3| 4| 3| 1| 6| 0| 6| 6| 3| 6| 4| 2| 7| 9| 9| 7| 4| 4| 0|
| 5| 1| 4| 5| 5| 3| 4| 5| 1| 0| 5| 8| 7| 1| 6| 3| 1| 3| 1| 7| 7| 1| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
30 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 1 1 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X |
Clear Cell Focus | |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia | |
Mineralization | 2 |
Necrosis | 3 2 1 |
Bile Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | M |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 |
Acinus, Hyperplasia | 2 2 2 2 1 2 |
__________________________________________________________________________|
Pharynx | + + + + + + + + + |
Palate, Abscess | |
Palate, Hyperplasia, Basal Cell | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | 2 2 2 |
Hyperplasia, Squamous | 1 2 1 2 2 |
Inflammation, Chronic Active | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia | |
Mineralization | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + +|
Acanthosis | 2 2 |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 3| 3| 3| 0| 0| 4| 4| 3| 3| 3| 4| 4| 3| 3| 3| 4| 4| 4| 3| 2| 3| 3| 3| 3| 3|
DAY ON TEST | 8| 7| 5| 8| 8| 6| 3| 4| 3| 1| 6| 0| 6| 6| 3| 6| 4| 2| 7| 9| 9| 7| 4| 4| 0|
| 5| 1| 4| 5| 5| 3| 4| 5| 1| 0| 5| 8| 7| 1| 6| 3| 1| 3| 1| 7| 7| 1| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
30 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 1 2 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | 3 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Interstitial Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + M + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 2 3 3 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M M + + + + + + + + M + + + + +|
Depletion Lymphoid | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + M + M + + M + + + + + M + + + + M|
Galactocele | X |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 3| 3| 3| 0| 0| 4| 4| 3| 3| 3| 4| 4| 3| 3| 3| 4| 4| 4| 3| 2| 3| 3| 3| 3| 3|
DAY ON TEST | 8| 7| 5| 8| 8| 6| 3| 4| 3| 1| 6| 0| 6| 6| 3| 6| 4| 2| 7| 9| 9| 7| 4| 4| 0|
| 5| 1| 4| 5| 5| 3| 4| 5| 1| 0| 5| 8| 7| 1| 6| 3| 1| 3| 1| 7| 7| 1| 5| 5| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
30 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Acute | 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus Tumor | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Acute | 2 2 2 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + + + + + |
Hemorrhage | 3 2 |
Inflammation, Acute | 3 2 |
Lens, Cataract | 2 2 |
__________________________________________________________________________|
Harderian Gland | + + + |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + M + + + + + + + + + + + +|
Nephropathy | 1|
Cortex, Mineralization | 1 1 1 |
Renal Tubule, Hyperplasia | 1 1 1 |
Renal Tubule, Regeneration | 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 4| 3| 3| 3| 2| 4| 3| 3| 2| 1| 4| 4| 4| 3| 3| 4| 4| 3| 3| 3| 4| 4| 3| 4| 3|
DAY ON TEST | 6| 7| 3| 2| 3| 0| 9| 5| 9| 8| 4| 1| 0| 3| 3| 6| 1| 8| 4| 4| 6| 5| 1| 1| 8|
| 4| 1| 6| 5| 3| 2| 9| 2| 4| 4| 1| 6| 7| 6| 1| 5| 2| 1| 5| 5| 5| 1| 1| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
30 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + M + + + + + + + + +|
Atrophy | |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X |
Clear Cell Focus | X |
Eosinophilic Focus | X X |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia | |
Mineralization | |
Necrosis | |
Bile Duct, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1|
Acinus, Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Pharynx | + + + + + + + + + +|
Palate, Abscess | |
Palate, Hyperplasia, Basal Cell | 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | 2 2 2 2 3 |
Hyperplasia, Squamous | 2 1 1 1 2 2 2 |
Inflammation, Chronic Active | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Mineralization | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 4| 3| 3| 3| 2| 4| 3| 3| 2| 1| 4| 4| 4| 3| 3| 4| 4| 3| 3| 3| 4| 4| 3| 4| 3|
DAY ON TEST | 6| 7| 3| 2| 3| 0| 9| 5| 9| 8| 4| 1| 0| 3| 3| 6| 1| 8| 4| 4| 6| 5| 1| 1| 8|
| 4| 1| 6| 5| 3| 2| 9| 2| 4| 4| 1| 6| 7| 6| 1| 5| 2| 1| 5| 5| 5| 1| 1| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
30 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + + + + + + + + + M + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Interstitial Cell, Hyperplasia | |
__________________________________________________________________________|
Oviduct | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + M + +|
Depletion Lymphoid | 2 2 |
Hematopoietic Cell Proliferation | 2 3 3 2 2 2 2 2 3 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M M + + + M + + + + + +|
Galactocele | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 4| 3| 3| 3| 2| 4| 3| 3| 2| 1| 4| 4| 4| 3| 3| 4| 4| 3| 3| 3| 4| 4| 3| 4| 3|
DAY ON TEST | 6| 7| 3| 2| 3| 0| 9| 5| 9| 8| 4| 1| 0| 3| 3| 6| 1| 8| 4| 4| 6| 5| 1| 1| 8|
| 4| 1| 6| 5| 3| 2| 9| 2| 4| 4| 1| 6| 7| 6| 1| 5| 2| 1| 5| 5| 5| 1| 1| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
30 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Embolus Tumor | X |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Inflammation, Acute | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + + + + + + + + + + |
Hemorrhage | |
Inflammation, Acute | |
Lens, Cataract | 2 2 2 |
__________________________________________________________________________|
Harderian Gland | + + + + + |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 1 1 1 1 |
Cortex, Mineralization | 1 1 |
Renal Tubule, Hyperplasia | 1 1 1 2 1 1 1 |
Renal Tubule, Regeneration | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 3| 2| 2| | |
DAY ON TEST | 6| 6| 6| 2| 3| 2| 0| 6| 5| 3| | |
| 5| 5| 5| 4| 0| 2| 0| 7| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
30 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Hyperkeratosis | 2 2 2 2 2 2 2 | 31 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
Atrophy | | 2 2.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X | 10 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | X | 3 |
Hepatodiaphragmatic Nodule | | 6 |
Hyperplasia | 2 | 1 2.0|
Mineralization | | 1 2.0|
Necrosis | 1 | 4 1.8|
Bile Duct, Hyperplasia | | 5 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | | 3 1.0|
Acinus, Hyperplasia | 1 1 | 11 1.6|
__________________________________________________________________________|____________|
Pharynx | + + + + | 23 |
Palate, Abscess | 2 | 1 2.0|
Palate, Hyperplasia, Basal Cell | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperplasia, Basal Cell | 1 | 9 2.0|
Hyperplasia, Squamous | 2 3 2 2 | 16 1.8|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Hyperplasia | 1 | 2 1.5|
Mineralization | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 3| 2| 2| | |
DAY ON TEST | 6| 6| 6| 2| 3| 2| 0| 6| 5| 3| | |
| 5| 5| 5| 4| 0| 2| 0| 7| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
30 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tongue | + + + + + + + | 35 |
Acanthosis | | 3 2.0|
Hyperkeratosis | 2 1 | 3 1.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 58 |
Cardiomyopathy | 2 | 9 1.7|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Metaplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Angiectasis | | 4 2.3|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 | 7 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Hyperplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
Hyperplasia | 3 | 3 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | | 3 |
Interstitial Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Oviduct | + + + + + | 42 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Endometrium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 3| 2| 2| | |
DAY ON TEST | 6| 6| 6| 2| 3| 2| 0| 6| 5| 3| | |
| 5| 5| 5| 4| 0| 2| 0| 7| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
30 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Depletion Lymphoid | | 3 2.0|
Hematopoietic Cell Proliferation | 2 2 2 3 3 2 | 32 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 57 |
Depletion Lymphoid | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + | 50 |
Galactocele | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Inflammation, Acute | | 1 3.0|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Peripheral Nerve | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Embolus Tumor | | 1 |
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | | 1 2.0|
Inflammation, Acute | 2 | 6 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | + | 19 |
Hemorrhage | | 2 2.5|
Inflammation, Acute | | 2 2.5|
Lens, Cataract | | 5 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 9 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 4| 3| 4| 4| 3| 2| 2| | |
DAY ON TEST | 6| 6| 6| 2| 3| 2| 0| 6| 5| 3| | |
| 5| 5| 5| 4| 0| 2| 0| 7| 1| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
30 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Nephropathy | 1 1 | 8 1.0|
Cortex, Mineralization | | 5 1.0|
Renal Tubule, Hyperplasia | 1 1 | 12 1.1|
Renal Tubule, Regeneration | | 3 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 4| 4| 3| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 5| 5| 4| 3| 3| 3| 1| 1| 3| 3| 3| 3| 0| 3| 9| 3| 0| 5| 3| 3| 3| 3| 5|
| 6| 6| 0| 0| 0| 6| 6| 6| 8| 4| 7| 6| 6| 1| 5| 6| 1| 6| 6| 2| 6| 6| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 |
Inflammation, Acute | 4 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X|
Clear Cell Focus | X X |
Congestion | 2 |
Fatty Change, Focal | 1 1 1 1 2|
Fibrosis | |
Mixed Cell Focus | X X X X |
Pigmentation | |
Bile Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | |
Fat, Mineralization | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 |
Acinus, Hyperplasia | 2 2 2 1 2 2 2 2 2 |
Artery, Inflammation, Chronic Active | 1 3 1 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 2 |
Inflammation, Chronic Active | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
__________________________________________________________________________|
Tongue | + + + +|
Hyperkeratosis | |
Hyperplasia, Basal Cell | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 4| 4| 3| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 5| 5| 4| 3| 3| 3| 1| 1| 3| 3| 3| 3| 0| 3| 9| 3| 0| 5| 3| 3| 3| 3| 5|
| 6| 6| 0| 0| 0| 6| 6| 6| 8| 4| 7| 6| 6| 1| 5| 6| 1| 6| 6| 2| 6| 6| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 |
Pars Distalis, Hyperplasia, | |
Multifocal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 1 1 2 2|
Seminiferous Tubule, Atrophy | 2 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 3 |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 4| 4| 3| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 5| 5| 4| 3| 3| 3| 1| 1| 3| 3| 3| 3| 0| 3| 9| 3| 0| 5| 3| 3| 3| 3| 5|
| 6| 6| 0| 0| 0| 6| 6| 6| 8| 4| 7| 6| 6| 1| 5| 6| 1| 6| 6| 2| 6| 6| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Degeneration | |
Infiltration Cellular, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 2 1 2 2 2 2 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +|
Epithelial Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + M + M M + + + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic Active | 2 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Infiltration Cellular, Histiocyte | |
Mediastinum, Inflammation, Acute | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 2 |
Hyperkeratosis | |
Inflammation, Acute | 2 2 |
Respiratory Epithelium, Hyperplasia | |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Synechia | 2 |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 4| 4| 3| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 4| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 5| 5| 4| 3| 3| 3| 1| 1| 3| 3| 3| 3| 0| 3| 9| 3| 0| 5| 3| 3| 3| 3| 5|
| 6| 6| 0| 0| 0| 6| 6| 6| 8| 4| 7| 6| 6| 1| 5| 6| 1| 6| 6| 2| 6| 6| 1| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Lens, Cataract | 2 |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 3 1 1 2 1 2 1 2 2 2 3 2 1 2 1 3 2 1 2 2 1 3 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 6| 7| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 6| 4| 5| 3| 1| 3| 7| 1| 3| 3| 3| 6| 5| 3| 3| 3| 9| 2|
| 6| 6| 6| 6| 5| 1| 1| 3| 8| 2| 1| 4| 1| 7| 0| 1| 1| 1| 3| 0| 7| 7| 7| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X |
Clear Cell Focus | |
Congestion | |
Fatty Change, Focal | 1 1 1 |
Fibrosis | |
Mixed Cell Focus | X X |
Pigmentation | |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + +|
Fat, Inflammation, Chronic Active | 2 |
Fat, Mineralization | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 3 2 1 2 |
Acinus, Hyperplasia | 2 1 1 1 2 3 2 3 2 2 3 2 2 2 1 |
Artery, Inflammation, Chronic Active | 2 3 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 |
Inflammation, Chronic Active | |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
__________________________________________________________________________|
Tongue | + + + + + |
Hyperkeratosis | 1 1 |
Hyperplasia, Basal Cell | 1 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 6| 7| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 6| 4| 5| 3| 1| 3| 7| 1| 3| 3| 3| 6| 5| 3| 3| 3| 9| 2|
| 6| 6| 6| 6| 5| 1| 1| 3| 8| 2| 1| 4| 1| 7| 0| 1| 1| 1| 3| 0| 7| 7| 7| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 1 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
Pars Distalis, Angiectasis | 2 3 3 2 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 2 2 |
Pars Distalis, Hyperplasia, | |
Multifocal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
Abscess | 3 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + M + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | 3 3 2 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Seminal Vesicle | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 2 2 2 1 |
Seminiferous Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | |
Mediastinal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 6| 7| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 6| 4| 5| 3| 1| 3| 7| 1| 3| 3| 3| 6| 5| 3| 3| 3| 9| 2|
| 6| 6| 6| 6| 5| 1| 1| 3| 8| 2| 1| 4| 1| 7| 0| 1| 1| 1| 3| 0| 7| 7| 7| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Degeneration | 2 |
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 3 2 1 2 2 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M + + M + + + + + + +|
Galactocele | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Inflammation, Chronic Active | 2 |
Necrosis | 3 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2|
Infiltration Cellular, Histiocyte | 1 |
Mediastinum, Inflammation, Acute | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 2 2 |
Hyperkeratosis | |
Inflammation, Acute | 3 2 1 2 |
Respiratory Epithelium, Hyperplasia | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Synechia | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 6| 7| 6| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 6| 4| 5| 3| 1| 3| 7| 1| 3| 3| 3| 6| 5| 3| 3| 3| 9| 2|
| 6| 6| 6| 6| 5| 1| 1| 3| 8| 2| 1| 4| 1| 7| 0| 1| 1| 1| 3| 0| 7| 7| 7| 2| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Lens, Cataract | |
__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 1 2 1 1 1 2 3 3 2 1 3 1 2 4 2 2 2 2 1 3 2 2 1 1|
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 8| 5| 3| 3| 5| 5| 5| | |
| 7| 7| 1| 9| 0| 6| 6| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Hyperkeratosis | | 2 2.0|
Inflammation, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 12 |
Clear Cell Focus | | 2 |
Congestion | | 1 2.0|
Fatty Change, Focal | 1 1 1 | 11 1.1|
Fibrosis | 2 | 1 2.0|
Mixed Cell Focus | X | 7 |
Pigmentation | 2 | 1 2.0|
Bile Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 5 |
Fat, Inflammation, Chronic Active | | 1 2.0|
Fat, Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | 2 | 10 1.5|
Acinus, Hyperplasia | 3 1 2 2 | 28 1.9|
Artery, Inflammation, Chronic Active | 2 | 6 2.0|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperplasia, Squamous | | 3 2.0|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Fibrosis | | 1 1.0|
__________________________________________________________________________|____________|
Tongue | + + + + + | 14 |
Hyperkeratosis | 1 | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 8| 5| 3| 3| 5| 5| 5| | |
| 7| 7| 1| 9| 0| 6| 6| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Basal Cell | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 2 | 39 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 59 |
Hyperplasia | | 10 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 5 1.8|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + M + + + | 57 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Angiectasis | 2 2 | 7 2.4|
Pars Distalis, Cyst | X | 3 |
Pars Distalis, Hyperplasia | 2 | 7 2.0|
Pars Distalis, Hyperplasia, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | 1 | 5 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 59 |
Abscess | | 2 3.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 58 |
Hyperplasia | 2 2 | 7 2.4|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Interstitial Cell, Hyperplasia | 1 2 2 2 1 | 16 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 8| 5| 3| 3| 5| 5| 5| | |
| 7| 7| 1| 9| 0| 6| 6| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Seminiferous Tubule, Atrophy | | 5 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Angiectasis | | 1 3.0|
Mediastinal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Angiectasis | 1 | 1 1.0|
Degeneration | | 1 2.0|
Infiltration Cellular, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 | 15 1.9|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 59 |
Epithelial Cell, Hyperplasia | | 4 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + M + M | 51 |
Galactocele | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Fibrosis | 2 | 2 2.0|
Inflammation, Chronic Active | 2 | 4 2.3|
Necrosis | | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 4| 7| 7| 4| 4| 4| | |
DAY ON TEST | 3| 3| 3| 8| 5| 3| 3| 5| 5| 5| | |
| 7| 7| 1| 9| 0| 6| 6| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Fibrosis | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 1.0|
Mediastinum, Inflammation, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 2 | 8 2.0|
Hyperkeratosis | 3 | 1 3.0|
Inflammation, Acute | 3 | 7 2.1|
Respiratory Epithelium, Hyperplasia | | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 2 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Synechia | | 1 2.0|
Lens, Cataract | | 1 2.0|
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy | 2 2 3 1 1 2 2 1 1 1 | 58 1.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Calculus Micro Observation Only | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 3| 8| 7| 3| 3| 1| 0| 5| 3| 9| 5| 8| 5| 3| 3| 3| 8| 9| 3| 3| 3| 5| 5|
| 0| 0| 0| 5| 8| 0| 0| 0| 0| 2| 0| 4| 6| 5| 2| 0| 0| 0| 9| 1| 0| 0| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X |
Eosinophilic Focus | X |
Fatty Change, Focal | 2 1 1 1 2|
Hepatodiaphragmatic Nodule | X |
Hyperplasia | |
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Mineralization | 2 2 |
Fat, Necrosis | 2 2 |
Fat, Pigmentation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 1 2 |
Acinus, Hyperplasia | 2 4 2 2 1 2 2 3 4 2 2 4 2 4 3 2 2 2 |
Acinus, Hyperplasia, Multiple | 2 2 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Pharynx | + + + + |
Palate, Hyperplasia, Basal Cell | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperplasia, Basal Cell | 2 1 |
Hyperplasia, Squamous | 2 1 2 2 3 2 1 1 2 2 2 2 2 1 |
Inflammation, Chronic Active | |
Ulcer | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + + + + + |
Hyperkeratosis | 1 |
Hyperplasia, Squamous | 2 |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 3| 8| 7| 3| 3| 1| 0| 5| 3| 9| 5| 8| 5| 3| 3| 3| 8| 9| 3| 3| 3| 5| 5|
| 0| 0| 0| 5| 8| 0| 0| 0| 0| 2| 0| 4| 6| 5| 2| 0| 0| 0| 9| 1| 0| 0| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 3 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + M + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 2 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 3 2 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 2 1 2 2|
Seminiferous Tubule, Atrophy | 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 3| 8| 7| 3| 3| 1| 0| 5| 3| 9| 5| 8| 5| 3| 3| 3| 8| 9| 3| 3| 3| 5| 5|
| 0| 0| 0| 5| 8| 0| 0| 0| 0| 2| 0| 4| 6| 5| 2| 0| 0| 0| 9| 1| 0| 0| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + + + + + + +|
Angiectasis | |
Degeneration | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 1 |
Hematopoietic Cell Proliferation | 2 3 1 2 2 1 2 2 |
Pigmentation | 3 |
__________________________________________________________________________|
Thymus | + + + M + M + + + + + + + + + + + + + + + + + + +|
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + M + + + + M + + + + + M + + + +|
Galactocele | X X |
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hemorrhage | 3 |
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 2 2 |
Inflammation, Acute | 2 2 2 |
Respiratory Epithelium, Hyperplasia | 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | 1 |
__________________________________________________________________________|
Harderian Gland | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 6| 4| 7| 6| 6| 6| 4| 7| 7| 7| 6| 5| 7| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 3| 8| 7| 3| 3| 1| 0| 5| 3| 9| 5| 8| 5| 3| 3| 3| 8| 9| 3| 3| 3| 5| 5|
| 0| 0| 0| 5| 8| 0| 0| 0| 0| 2| 0| 4| 6| 5| 2| 0| 0| 0| 9| 1| 0| 0| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
3 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Necrosis | 1 |
Nephropathy | 1 2 2 1 1 2 2 2 2 1 4 2 1 2 1 3 2 3 1 1 2 2 2 2 1|
Renal Tubule, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 4| 4| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 6| 0| 0| 3| 3| 0| 5| 5| 3| 3| 5| 5| 5| 3| 3| 3| 3| 7| 3| 3| 3| 9| 2|
| 1| 1| 3| 3| 3| 1| 0| 3| 2| 2| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 0| 0| 0| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X |
Clear Cell Focus | X X |
Eosinophilic Focus | X |
Fatty Change, Focal | 1 1 1 |
Hepatodiaphragmatic Nodule | X |
Hyperplasia | |
Mixed Cell Focus | X X X X X X |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Mineralization | |
Fat, Necrosis | 3 3 |
Fat, Pigmentation | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 1 2 1 2 |
Acinus, Hyperplasia | 2 3 2 3 2 2 2 2 3 3 1 3 2 3 3 3 2 2 2 4 2|
Acinus, Hyperplasia, Multiple | |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Pharynx | + |
Palate, Hyperplasia, Basal Cell | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperplasia, Basal Cell | 2 2 |
Hyperplasia, Squamous | 1 2 4 2 2 2 3 3 |
Inflammation, Chronic Active | 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + + |
Hyperkeratosis | 1 |
Hyperplasia, Squamous | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 4| 4| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 6| 0| 0| 3| 3| 0| 5| 5| 3| 3| 5| 5| 5| 3| 3| 3| 3| 7| 3| 3| 3| 9| 2|
| 1| 1| 3| 3| 3| 1| 0| 3| 2| 2| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 0| 0| 0| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 3 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 2 2 2 2|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 2 2 1 1 2 1|
Seminiferous Tubule, Atrophy | 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 4| 4| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 6| 0| 0| 3| 3| 0| 5| 5| 3| 3| 5| 5| 5| 3| 3| 3| 3| 7| 3| 3| 3| 9| 2|
| 1| 1| 3| 3| 3| 1| 0| 3| 2| 2| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 0| 0| 0| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Degeneration | 2|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 2 2 3 2 1 2 1 2 3 2 2|
Pigmentation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + M + M + + + + M + + + M + + + M + + + + + + +|
Galactocele | X |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + M + + + + + + + + + + + +|
Acanthosis | |
Hemorrhage | |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 |
Inflammation, Acute | 1 2 2 |
Respiratory Epithelium, Hyperplasia | 2 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Lens, Cataract | |
__________________________________________________________________________|
Harderian Gland | + |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 6| 7| 7| 7| 4| 4| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 6| 0| 0| 3| 3| 0| 5| 5| 3| 3| 5| 5| 5| 3| 3| 3| 3| 7| 3| 3| 3| 9| 2|
| 1| 1| 3| 3| 3| 1| 0| 3| 2| 2| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7| 0| 0| 0| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
3 MG/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Necrosis | |
Nephropathy | 2 2 2 4 1 2 2 1 1 1 2 3 1 1 2 3 2 1 3 1 1 1 2 4 3|
Renal Tubule, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 3| 9| 5| 3| 3| 3| 3| 5| | |
| 1| 1| 1| 2| 0| 1| 1| 1| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
3 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
Hyperkeratosis | 2 | 3 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X | 8 |
Clear Cell Focus | X | 5 |
Eosinophilic Focus | | 2 |
Fatty Change, Focal | 1 | 9 1.2|
Hepatodiaphragmatic Nodule | X | 3 |
Hyperplasia | 3 | 1 3.0|
Mixed Cell Focus | X X | 8 |
Bile Duct, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | | 9 |
Fat, Mineralization | | 2 2.0|
Fat, Necrosis | | 4 2.5|
Fat, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | 1 1 | 13 1.4|
Acinus, Hyperplasia | 2 2 3 2 3 3 2 | 46 2.5|
Acinus, Hyperplasia, Multiple | | 2 2.0|
Artery, Inflammation, Chronic Active | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Pharynx | | 5 |
Palate, Hyperplasia, Basal Cell | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Duct, Metaplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Cyst Epithelial Inclusion | 2 | 1 2.0|
Hyperplasia, Basal Cell | 3 2 2 | 7 2.0|
Hyperplasia, Squamous | 2 3 3 3 2 2 | 28 2.1|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 3| 9| 5| 3| 3| 3| 3| 5| | |
| 1| 1| 1| 2| 0| 1| 1| 1| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
3 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Tongue | + | 8 |
Hyperkeratosis | | 2 1.0|
Hyperplasia, Squamous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Cardiomyopathy | 3 2 2 2 2 2 2 2 | 43 2.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Degeneration, Fatty | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 1 | 8 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + | 55 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + | 58 |
Pars Distalis, Angiectasis | 2 | 10 2.1|
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 | 11 2.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Hyperplasia | | 3 1.7|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Preputial Gland | + M + + + M + + + + | 57 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + M + + + | 58 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Interstitial Cell, Hyperplasia | 2 | 14 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 3| 9| 5| 3| 3| 3| 3| 5| | |
| 1| 1| 1| 2| 0| 1| 1| 1| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
3 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Seminiferous Tubule, Atrophy | 3 | 5 3.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 3 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Pigmentation | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Angiectasis | | 1 3.0|
Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 5 2.2|
Hematopoietic Cell Proliferation | 1 2 3 1 2 | 24 1.9|
Pigmentation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 58 |
Epithelial Cell, Hyperplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + | 50 |
Galactocele | | 3 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + M + + + | 58 |
Acanthosis | | 1 2.0|
Hemorrhage | | 1 3.0|
Hyperkeratosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| | |
DAY ON TEST | 3| 3| 3| 9| 5| 3| 3| 3| 3| 5| | |
| 1| 1| 1| 2| 0| 1| 1| 1| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
3 MG/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Infiltration Cellular, Histiocyte | 2 | 3 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 2 | 6 2.2|
Inflammation, Acute | 2 | 7 1.9|
Respiratory Epithelium, Hyperplasia | | 3 1.7|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
Lens, Cataract | | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | X | 1 |
Necrosis | | 1 1.0|
Nephropathy | 2 3 2 2 1 1 1 2 3 2 | 60 1.9|
Renal Tubule, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 0| 6| 6| 6| 5| 4| 5| 7| 6| 5| 4| 7| 7| 7| 5| 4| 7| 7| 5| 4| 0|
DAY ON TEST | 9| 5| 4| 3| 0| 8| 6| 4| 2| 5| 3| 2| 6| 3| 5| 3| 2| 2| 9| 5| 3| 2| 4| 5| 2|
| 8| 5| 1| 8| 8| 4| 0| 9| 0| 2| 8| 9| 3| 6| 2| 0| 9| 9| 6| 0| 0| 9| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 3 2 |
Necrosis | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Acute | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Metaplasia, Osseous | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X |
Clear Cell Focus | X |
Fatty Change, Focal | 2 1 |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X X |
Bile Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Mesentery | + + + + +|
Fat, Fibrosis | |
Fat, Hemorrhage | 3|
Fat, Inflammation, Chronic Active | 2|
Fat, Mineralization | 3 2|
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
Acinus, Hyperplasia | 3 3 3 3 2 2 3 2 3 2 2 3 2 2 3 2 2 2 2 2 |
Artery, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Pharynx | + + + + |
Palate, Hyperplasia, Squamous | |
Palate, Ulcer | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | 2 1 2 2 1 2 |
Hyperplasia, Squamous | 2 2 2 1 2 3 |
Inflammation, Chronic Active | 2 1 |
Ulcer | 2 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 0| 6| 6| 6| 5| 4| 5| 7| 6| 5| 4| 7| 7| 7| 5| 4| 7| 7| 5| 4| 0|
DAY ON TEST | 9| 5| 4| 3| 0| 8| 6| 4| 2| 5| 3| 2| 6| 3| 5| 3| 2| 2| 9| 5| 3| 2| 4| 5| 2|
| 8| 5| 1| 8| 8| 4| 0| 9| 0| 2| 8| 9| 3| 6| 2| 0| 9| 9| 6| 0| 0| 9| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | + + + + + + + + |
Acanthosis | |
Hyperkeratosis | |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 3 2 2 2 2 2 2 2 3 2 2 2 2 |
Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 1 2 2 2 3 3 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 1 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 3 |
Inflammation, Acute | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 0| 6| 6| 6| 5| 4| 5| 7| 6| 5| 4| 7| 7| 7| 5| 4| 7| 7| 5| 4| 0|
DAY ON TEST | 9| 5| 4| 3| 0| 8| 6| 4| 2| 5| 3| 2| 6| 3| 5| 3| 2| 2| 9| 5| 3| 2| 4| 5| 2|
| 8| 5| 1| 8| 8| 4| 0| 9| 0| 2| 8| 9| 3| 6| 2| 0| 9| 9| 6| 0| 0| 9| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 2 2 |
Seminiferous Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 2 2 |
Mediastinal, Pigmentation | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 1 2 3 2 2 2 2 3 1 1 2 2 2 1 |
Mineralization | |
__________________________________________________________________________|
Thymus | M + M + + + + + + + + + + + M + M M + + + + + +|
Depletion Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M + + + + M + M M M + + + M M M + + + + +|
Galactocele | |
__________________________________________________________________________|
Skin | + + M + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
__________________________________________________________________________|
Skeletal Muscle | + + + |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 0| 6| 6| 6| 5| 4| 5| 7| 6| 5| 4| 7| 7| 7| 5| 4| 7| 7| 5| 4| 0|
DAY ON TEST | 9| 5| 4| 3| 0| 8| 6| 4| 2| 5| 3| 2| 6| 3| 5| 3| 2| 2| 9| 5| 3| 2| 4| 5| 2|
| 8| 5| 1| 8| 8| 4| 0| 9| 0| 2| 8| 9| 3| 6| 2| 0| 9| 9| 6| 0| 0| 9| 0| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 3 |
Inflammation, Acute | 2 2 3 3 |
Nasolacrimal Duct, Inflammation, | |
Acute | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Synechia | |
Lens, Cataract | 2 |
Retina, Atrophy | 2 |
__________________________________________________________________________|
Harderian Gland | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hydronephrosis | |
Necrosis | |
Nephropathy | 2 3 2 1 2 2 2 2 2 3 3 2 2 2 3 4 4 3 1 3 4 2 2 |
Bilateral, Hydronephrosis | 3|
Cortex, Mineralization | 2 2 1|
Renal Tubule, Hyperplasia | 2 2 1 2 2 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 7| 2| 7| 6| 5| 4| 4| 6| 6| 6| 4| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 2| 2| 8| 4| 0| 2| 2| 2| 0| 2| 0| 8| 1| 4| 0| 8| 7| 1| 5| 5| 2| 2| 6| 2| 5|
| 9| 9| 5| 9| 4| 9| 9| 0| 1| 5| 9| 6| 4| 9| 4| 5| 8| 2| 0| 0| 9| 9| 8| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 2 2 |
Necrosis | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Metaplasia, Osseous | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X|
Clear Cell Focus | X X|
Fatty Change, Focal | 1|
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | X X X |
Bile Duct, Hyperplasia | 2 2 2|
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Fibrosis | 2 |
Fat, Hemorrhage | |
Fat, Inflammation, Chronic Active | |
Fat, Mineralization | 2 2 |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 1 1 1 2 1 2 |
Acinus, Hyperplasia | 2 2 2 2 2 2 2 2 2 3 3 2 2 3 2 3 2 2 2 2 4 3 2|
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Pharynx | + + + + + + + + + + + + +|
Palate, Hyperplasia, Squamous | 2 |
Palate, Ulcer | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | 2 2 2 2 |
Hyperplasia, Squamous | 2 4 4 2 1 2 |
Inflammation, Chronic Active | |
Ulcer | 2 2 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 7| 2| 7| 6| 5| 4| 4| 6| 6| 6| 4| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 2| 2| 8| 4| 0| 2| 2| 2| 0| 2| 0| 8| 1| 4| 0| 8| 7| 1| 5| 5| 2| 2| 6| 2| 5|
| 9| 9| 5| 9| 4| 9| 9| 0| 1| 5| 9| 6| 4| 9| 4| 5| 8| 2| 0| 0| 9| 9| 8| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | + + |
Acanthosis | 1 1 |
Hyperkeratosis | 1 |
Inflammation, Acute | |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 3 2 2 2 3 2 2 2 3 3 |
Fibrosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | M M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 2 2 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 2 2 3 2 2 1 |
Pars Intermedia, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation, Chronic Active | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 |
Inflammation, Acute | 3 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 7| 2| 7| 6| 5| 4| 4| 6| 6| 6| 4| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 2| 2| 8| 4| 0| 2| 2| 2| 0| 2| 0| 8| 1| 4| 0| 8| 7| 1| 5| 5| 2| 2| 6| 2| 5|
| 9| 9| 5| 9| 4| 9| 9| 0| 1| 5| 9| 6| 4| 9| 4| 5| 8| 2| 0| 0| 9| 9| 8| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 1 2 2 2 2 2|
Seminiferous Tubule, Atrophy | 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
Inflammation, Granulomatous | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 3 2 3 |
Mineralization | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M M +|
Depletion Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + M + + + + + + + + + + + + + + + + M M +|
Galactocele | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 |
__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation, Acute | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 7| 7| 2| 7| 6| 5| 4| 4| 6| 6| 6| 4| 4| 7| 7| 6| 5| 4|
DAY ON TEST | 2| 2| 8| 4| 0| 2| 2| 2| 0| 2| 0| 8| 1| 4| 0| 8| 7| 1| 5| 5| 2| 2| 6| 2| 5|
| 9| 9| 5| 9| 4| 9| 9| 0| 1| 5| 9| 6| 4| 9| 4| 5| 8| 2| 0| 0| 9| 9| 8| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 3 3 |
Inflammation, Acute | 2 2 1 3 |
Nasolacrimal Duct, Inflammation, | |
Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
Synechia | 1 |
Lens, Cataract | 2 |
Retina, Atrophy | |
__________________________________________________________________________|
Harderian Gland | + |
Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Hydronephrosis | 3 |
Necrosis | 3 |
Nephropathy | 3 4 4 3 1 4 2 2 2 1 3 4 2 2 2 4 4 3 2 1 4 3 4 1 2|
Bilateral, Hydronephrosis | |
Cortex, Mineralization | |
Renal Tubule, Hyperplasia | 1 1 3 2 1 1 1 2 2 2 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Calculus Micro Observation Only | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 4| 4| 7| 7| 7| 6| 4| | |
DAY ON TEST | 1| 9| 7| 5| 5| 2| 2| 2| 6| 5| | |
| 4| 0| 2| 0| 0| 9| 9| 8| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
Hyperkeratosis | | 8 2.1|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 57 |
Inflammation, Chronic Active | | 1 2.0|
Metaplasia, Osseous | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Basophilic Focus | X X X | 18 |
Clear Cell Focus | X | 4 |
Fatty Change, Focal | | 3 1.3|
Hepatodiaphragmatic Nodule | X X | 6 |
Mixed Cell Focus | X | 6 |
Bile Duct, Hyperplasia | 2 2 | 6 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 12 |
Fat, Fibrosis | | 1 2.0|
Fat, Hemorrhage | | 1 3.0|
Fat, Inflammation, Chronic Active | | 1 2.0|
Fat, Mineralization | | 4 2.3|
Fat, Necrosis | | 3 2.3|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Acinus, Atrophy | | 8 1.4|
Acinus, Hyperplasia | 2 2 3 1 2 2 2 2 2 1 | 53 2.3|
Artery, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Pharynx | + | 18 |
Palate, Hyperplasia, Squamous | | 1 2.0|
Palate, Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Duct, Metaplasia, Squamous | 1 | 2 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Hyperplasia, Basal Cell | 2 1 | 12 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 4| 4| 7| 7| 7| 6| 4| | |
DAY ON TEST | 1| 9| 7| 5| 5| 2| 2| 2| 6| 5| | |
| 4| 0| 2| 0| 0| 9| 9| 8| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Squamous | 1 | 13 2.2|
Inflammation, Chronic Active | | 2 1.5|
Ulcer | | 7 2.1|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + + + | 13 |
Acanthosis | | 2 1.0|
Hyperkeratosis | | 1 1.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Cardiomyopathy | 2 2 2 2 2 2 | 37 2.2|
Fibrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 58 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 58 |
Hyperplasia | 1 | 9 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 57 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Angiectasis | | 3 2.7|
Pars Distalis, Cyst | | 2 |
Pars Distalis, Hyperplasia | 2 2 | 14 2.1|
Pars Intermedia, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Hyperplasia | 2 | 8 1.3|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 4| 4| 7| 7| 7| 6| 4| | |
DAY ON TEST | 1| 9| 7| 5| 5| 2| 2| 2| 6| 5| | |
| 4| 0| 2| 0| 0| 9| 9| 8| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 59 |
Hyperplasia | | 1 1.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Hyperplasia | 2 3 | 10 2.2|
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 59 |
Interstitial Cell, Hyperplasia | 2 2 2 2 | 13 1.8|
Seminiferous Tubule, Atrophy | | 3 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 3 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 59 |
Mediastinal, Angiectasis | | 2 2.0|
Mediastinal, Pigmentation | 2 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + | 58 |
Degeneration | | 1 3.0|
Inflammation, Granulomatous | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 57 |
Hemorrhage | | 1 3.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 2 2 2 2 | 31 2.1|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + | 51 |
Depletion Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M + M + M M + + | 41 |
Galactocele | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 58 |
Hyperkeratosis | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 4| 4| 7| 7| 7| 6| 4| | |
DAY ON TEST | 1| 9| 7| 5| 5| 2| 2| 2| 6| 5| | |
| 4| 0| 2| 0| 0| 9| 9| 8| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
Fibrous Osteodystrophy | | 1 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 5 |
Inflammation, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Edema | | 1 2.0|
Inflammation, Acute | 3 | 4 2.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Fungus | | 6 2.5|
Inflammation, Acute | 2 3 | 10 2.3|
Nasolacrimal Duct, Inflammation, | | |
Acute | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | + + + | 7 |
Synechia | | 1 1.0|
Lens, Cataract | 2 3 | 4 2.3|
Retina, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Cyst | | 3 |
Hydronephrosis | | 1 3.0|
Necrosis | | 1 3.0|
Nephropathy | 3 1 1 1 2 3 3 2 3 2 | 58 2.5|
Bilateral, Hydronephrosis | | 1 3.0|
Cortex, Mineralization | | 3 1.7|
Renal Tubule, Hyperplasia | 1 1 1 1 | 23 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 6| 5| 4| 4| 4| 7| 7| 7| 6| 4| | |
DAY ON TEST | 1| 9| 7| 5| 5| 2| 2| 2| 6| 5| | |
| 4| 0| 2| 0| 0| 9| 9| 8| 9| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 57 |
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 5| 4| 4| 3| 3| 4| 4| 4| 3| 3| 5| 4| 5| 4| 4| 4| 4| 4| 4| 3| 5| 5| 5| 4| 3|
DAY ON TEST | 3| 8| 4| 9| 8| 7| 5| 5| 6| 6| 3| 8| 3| 3| 2| 8| 7| 5| 5| 6| 3| 3| 2| 5| 8|
| 4| 0| 8| 5| 2| 0| 2| 2| 9| 8| 4| 7| 4| 2| 5| 1| 8| 0| 0| 1| 4| 4| 0| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 |
Necrosis | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X |
Clear Cell Focus | X X |
Cyst | X |
Eosinophilic Focus | X X |
Fatty Change, Focal | 1 |
Fibrosis | 2 |
Hepatodiaphragmatic Nodule | |
Hyperplasia | 2 2 |
Infarct | 4 |
Mixed Cell Focus | X X X |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Mesentery | + + |
Fat, Inflammation, Chronic Active | 3 |
Fat, Pigmentation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 1 2 |
Acinus, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 3 2|
__________________________________________________________________________|
Pharynx | + + + + + + |
Hyperplasia, Basal Cell | |
Hyperplasia, Squamous | |
Palate, Hyperplasia, Basal Cell | |
Palate, Hyperplasia, Squamous | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | 2 2 2 2 2 2 |
Hyperplasia, Squamous | 1 2 2 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 5| 4| 4| 3| 3| 4| 4| 4| 3| 3| 5| 4| 5| 4| 4| 4| 4| 4| 4| 3| 5| 5| 5| 4| 3|
DAY ON TEST | 3| 8| 4| 9| 8| 7| 5| 5| 6| 6| 3| 8| 3| 3| 2| 8| 7| 5| 5| 6| 3| 3| 2| 5| 8|
| 4| 0| 8| 5| 2| 0| 2| 2| 9| 8| 4| 7| 4| 2| 5| 1| 8| 0| 0| 1| 4| 4| 0| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Basal Cell | |
Inflammation, Acute | 2 2 2 2 2|
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 2 2 2 2 2 2 2 3 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 2 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Abscess | 2 |
Hyperplasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 5| 4| 4| 3| 3| 4| 4| 4| 3| 3| 5| 4| 5| 4| 4| 4| 4| 4| 4| 3| 5| 5| 5| 4| 3|
DAY ON TEST | 3| 8| 4| 9| 8| 7| 5| 5| 6| 6| 3| 8| 3| 3| 2| 8| 7| 5| 5| 6| 3| 3| 2| 5| 8|
| 4| 0| 8| 5| 2| 0| 2| 2| 9| 8| 4| 7| 4| 2| 5| 1| 8| 0| 0| 1| 4| 4| 0| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 2 |
Mediastinal, Infiltration Cellular, | |
Polymorphonuclear | |
Mediastinal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 1 2 2 2 2 2 3 2 2 2 2 2 |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Depletion Lymphoid | |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + M + + + + M + + + + + M + + M M + + + M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperkeratosis | 3 |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
Alveolar Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 |
Inflammation, Acute | 3 2 3 |
Respiratory Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
Synechia | |
Lens, Cataract | 2 2 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 5| 4| 4| 3| 3| 4| 4| 4| 3| 3| 5| 4| 5| 4| 4| 4| 4| 4| 4| 3| 5| 5| 5| 4| 3|
DAY ON TEST | 3| 8| 4| 9| 8| 7| 5| 5| 6| 6| 3| 8| 3| 3| 2| 8| 7| 5| 5| 6| 3| 3| 2| 5| 8|
| 4| 0| 8| 5| 2| 0| 2| 2| 9| 8| 4| 7| 4| 2| 5| 1| 8| 0| 0| 1| 4| 4| 0| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Zymbal's Gland | + + + + |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 2 1 2 2 3 2 2 2 2 4 2 3 2 3 3 3 2 3 2 3 2 3 3 2|
Renal Tubule, Hyperplasia, Eosinophil| |
Renal Tubule, Hyperplasia | 2 2 2 3 2 1 2 1 2 2 2 1 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X X |
Calculus Micro Observation Only | X X |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 5| 5| 4| 4| 3| 5| 5| 4| 4| 3| 5| 5| 4| 4| 4|
DAY ON TEST | 9| 8| 7| 5| 2| 8| 8| 5| 5| 2| 3| 2| 9| 4| 6| 3| 1| 9| 3| 3| 3| 1| 8| 7| 5|
| 3| 7| 0| 2| 3| 4| 4| 2| 2| 7| 4| 7| 3| 4| 9| 4| 1| 4| 2| 7| 4| 9| 7| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3|
Necrosis | 2 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X |
Clear Cell Focus | X X X |
Cyst | |
Eosinophilic Focus | X |
Fatty Change, Focal | |
Fibrosis | |
Hepatodiaphragmatic Nodule | |
Hyperplasia | |
Infarct | 4 |
Mixed Cell Focus | X X |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 1 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | |
Fat, Pigmentation | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Acinus, Hyperplasia | 2 2 2 2 2 2 2 3 1 1 3 2 2 2 2 3 2 2 2 2 2 2 2|
__________________________________________________________________________|
Pharynx | + + + + + + |
Hyperplasia, Basal Cell | 2 |
Hyperplasia, Squamous | 4 |
Palate, Hyperplasia, Basal Cell | |
Palate, Hyperplasia, Squamous | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Metaplasia, Squamous | 1 1 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Basal Cell | 2 2 |
Hyperplasia, Squamous | 2 |
Ulcer | 2 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 5| 5| 4| 4| 3| 5| 5| 4| 4| 3| 5| 5| 4| 4| 4|
DAY ON TEST | 9| 8| 7| 5| 2| 8| 8| 5| 5| 2| 3| 2| 9| 4| 6| 3| 1| 9| 3| 3| 3| 1| 8| 7| 5|
| 3| 7| 0| 2| 3| 4| 4| 2| 2| 7| 4| 7| 3| 4| 9| 4| 1| 4| 2| 7| 4| 9| 7| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 2 2 |
Hyperplasia, Basal Cell | 1 3 |
Inflammation, Acute | 2 2 2 2 2 2 2 2 2|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 2 2 2 2 2 2 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + + + + + M + + + + + M + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 1 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 |
Follicular Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Hyperplasia | 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 5| 5| 4| 4| 3| 5| 5| 4| 4| 3| 5| 5| 4| 4| 4|
DAY ON TEST | 9| 8| 7| 5| 2| 8| 8| 5| 5| 2| 3| 2| 9| 4| 6| 3| 1| 9| 3| 3| 3| 1| 8| 7| 5|
| 3| 7| 0| 2| 3| 4| 4| 2| 2| 7| 4| 7| 3| 4| 9| 4| 1| 4| 2| 7| 4| 9| 7| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | |
Mediastinal, Infiltration Cellular, | |
Polymorphonuclear | 3 |
Mediastinal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 1 2 2 1 |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + M + + + + + + + + + + + + +|
Cyst | |
Depletion Lymphoid | |
Epithelial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + M + + M + + + M + + + M + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Acute | 1 2 1|
Respiratory Epithelium, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Synechia | |
Lens, Cataract | 2 2 |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
_____________________________________________________________________________________________________________________
| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 5| 5| 4| 4| 3| 5| 5| 4| 4| 3| 5| 5| 4| 4| 4|
DAY ON TEST | 9| 8| 7| 5| 2| 8| 8| 5| 5| 2| 3| 2| 9| 4| 6| 3| 1| 9| 3| 3| 3| 1| 8| 7| 5|
| 3| 7| 0| 2| 3| 4| 4| 2| 2| 7| 4| 7| 3| 4| 9| 4| 1| 4| 2| 7| 4| 9| 7| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
30 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
Necrosis | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 2 2 2 3 3 4 3 2 2 3 3 3 1 2 2 3 3 2 1 2 3 3 2 2|
Renal Tubule, Hyperplasia, Eosinophil| 2 |
Renal Tubule, Hyperplasia | 2 1 2 2 2 1 1 2 1 1 2 1 2 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X X |
Calculus Micro Observation Only | X X |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 4| 4| 5| 4| 4| 4| 4| | |
DAY ON TEST | 3| 1| 0| 9| 7| 1| 8| 5| 2| 0| | |
| 4| 2| 1| 5| 9| 2| 5| 2| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
30 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + + + + + + + + | 59 |
Hyperkeratosis | 3 3 2 2 3 | 35 2.1|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + M + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Diverticulum | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | X X | 10 |
Clear Cell Focus | | 5 |
Cyst | | 1 |
Eosinophilic Focus | | 3 |
Fatty Change, Focal | | 1 1.0|
Fibrosis | | 1 2.0|
Hepatodiaphragmatic Nodule | X X | 2 |
Hyperplasia | | 2 2.0|
Infarct | | 2 4.0|
Mixed Cell Focus | X X | 7 |
Bile Duct, Hyperplasia | 2 | 20 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Fat, Inflammation, Chronic Active | | 1 3.0|
Fat, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | | 2 1.5|
Acinus, Hyperplasia | 2 2 2 2 2 2 1 2 3 2 | 57 2.1|
__________________________________________________________________________|____________|
Pharynx | + + + + | 16 |
Hyperplasia, Basal Cell | | 1 2.0|
Hyperplasia, Squamous | | 1 4.0|
Palate, Hyperplasia, Basal Cell | 2 2 | 2 2.0|
Palate, Hyperplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Duct, Metaplasia, Squamous | 1 | 6 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 4| 4| 5| 4| 4| 4| 4| | |
DAY ON TEST | 3| 1| 0| 9| 7| 1| 8| 5| 2| 0| | |
| 4| 2| 1| 5| 9| 2| 5| 2| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
30 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia, Basal Cell | 2 | 9 2.0|
Hyperplasia, Squamous | 2 2 | 6 1.8|
Ulcer | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + | 47 |
Hyperkeratosis | 2 1 | 5 1.8|
Hyperplasia, Basal Cell | | 2 2.0|
Inflammation, Acute | 2 1 | 16 1.9|
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 | 27 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + M + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + M + + + + + + + + | 59 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + + + + + + + | 59 |
Hyperplasia | | 3 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + M | 53 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Hyperplasia | 2 2 2 | 10 1.9|
__________________________________________________________________________|____________|
Thyroid Gland | M + + + + + + + + + | 59 |
C-Cell, Hyperplasia | | 4 1.5|
Follicular Cell, Hyperplasia | 2 | 4 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + M + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 4| 4| 5| 4| 4| 4| 4| | |
DAY ON TEST | 3| 1| 0| 9| 7| 1| 8| 5| 2| 0| | |
| 4| 2| 1| 5| 9| 2| 5| 2| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
30 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Abscess | | 2 2.5|
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Interstitial Cell, Hyperplasia | 2 | 24 1.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Angiectasis | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Polymorphonuclear | | 1 3.0|
Mediastinal, Pigmentation | 2 | 3 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Infiltration Cellular, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 2 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 | 31 1.9|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + | 56 |
Cyst | | 1 |
Depletion Lymphoid | 2 | 1 2.0|
Epithelial Cell, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + M + + + + + | 46 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Hyperkeratosis | 3 | 3 3.0|
Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05111-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 1,2,3-TRICHLOROPROPANE Date: 04/17/97
Route: GAVAGE Time: 08:45:58
__________________________________________________________________________________________________________________________________
| 5| 5| 5| 4| 4| 5| 4| 4| 4| 4| | |
DAY ON TEST | 3| 1| 0| 9| 7| 1| 8| 5| 2| 0| | |
| 4| 2| 1| 5| 9| 2| 5| 2| 4| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
30 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Inflammation, Acute | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | | 1 2.0|
Inflammation, Acute | | 6 2.0|
Respiratory Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 8 |
Synechia | 2 | 1 2.0|
Lens, Cataract | | 4 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 4 |
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy | 2 3 2 3 4 3 2 2 2 2 | 60 2.4|
Renal Tubule, Hyperplasia, Eosinophil| 1 | 2 1.5|
Renal Tubule, Hyperplasia | 2 1 1 2 1 1 2 | 36 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Calculus Gross Observation | | 4 |
Calculus Micro Observation Only | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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