TDMS Study 05111-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/14/94
EXP: 05111 1,2,3-TRICHLOROPROPANE TIME: 05:26:28
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60220B
CONT: N01-ES-45048 CAS: 96-18-4
PATHOLOGIST: K. MURTHY S. EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
ALL
REMOVAL DATE RANGE:
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TREATMENT GROUPS:
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Mason DATE: 09/14/94
EXP: 05111 1,2,3-TRICHLOROPROPANE TIME: 05:26:28
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 60220B
CONT: N01-ES-45048 CAS: 96-18-4
PATHOLOGIST: K. MURTHY S. EUSTIS
1,2,3-TRICHLOROPROPANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 15 CENSORED DEATHS 11 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 340 485 506 589 591 605 614 614 618 628 |
| 648 663 663 677 692 |
| CENSORED DEATHS |
| 450 450 450 450 450 452 452 452 452 452 |
| 610 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 18 CENSORED DEATHS 10 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 577 591 600 603 603 621 654 656 663 678 |
| 685 685 689 692 692 694 703 710 |
| CENSORED DEATHS |
| 450 450 450 450 450 452 452 452 452 452 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 MG/KG |
| --------------------- |
| |
| TOTAL 59 UNCENSORED DEATHS 34 CENSORED DEATHS 11 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 25 404 404 449 472 514 520 524 536 538 |
| 540 590 596 612 614 638 641 649 649 655 |
| 660 663 668 669 678 684 685 685 686 698 |
| 701 709 720 728 |
| CENSORED DEATHS |
| 225 450 450 450 450 450 450 452 452 452 |
| 452 |
| |
==================================================================================
1,2,3-TRICHLOROPROPANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 30 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 43 CENSORED DEATHS 17 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 327 337 361 368 369 369 382 388 395 401 |
| 423 424 425 432 432 444 448 452 459 470 |
| 470 473 478 479 480 481 484 484 485 487 |
| 487 487 493 493 494 495 501 511 512 512 |
| 519 520 527 |
| CENSORED DEATHS |
| 450 450 450 452 452 452 452 452 534 534 |
| 534 534 534 534 534 534 534 |
| |
==================================================================================
1,2,3-TRICHLOROPROPANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 98.3 98.3 96.3 94.3 88.3 73.9 69.8 |
| | |
| | |
|3 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 90.0 82.0 64.0 |
| | |
| | |
|10 MG/KG | 98.3 98.3 98.3 98.3 94.9 91.0 78.3 74.1 55.0 29.6 |
| | |
| | |
|30 MG/KG | 100.0 100.0 100.0 95.0 78.3 47.3 0.0 0.0 0.0 0.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 69.8% 64.0% 29.6% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.884 P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 595.5 655.3 594.2 452.5 |
|NATURAL DEATHS (C) | (23.5) (10.4) (23.2) ( 8.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 647.3 660.6 595.6 464.6 |
|(STANDARD ERROR) | (14.7) (13.3) (18.7) ( 7.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
1,2,3-TRICHLOROPROPANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 19 CENSORED DEATHS 10 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 424 450 474 526 547 550 550 597 601 626 |
| 645 647 652 670 683 699 708 714 717 |
| CENSORED DEATHS |
| 463 463 463 463 463 463 465 465 465 465 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 3 MG/KG |
| --------------------- |
| |
| TOTAL 59 UNCENSORED DEATHS 19 CENSORED DEATHS 10 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 434 460 469 510 545 580 589 604 664 670 |
| 677 690 695 696 708 713 713 725 729 |
| CENSORED DEATHS |
| 463 463 463 463 463 465 465 465 465 465 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 10 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 44 CENSORED DEATHS 8 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 255 405 405 424 434 450 451 479 505 510 |
| 510 513 520 521 538 538 550 557 561 563 |
| 572 581 584 598 604 605 608 608 612 628 |
| 634 637 641 642 643 669 676 683 699 701 |
| 709 721 725 725 |
| CENSORED DEATHS |
| 463 463 463 463 463 465 465 465 |
| |
==================================================================================
1,2,3-TRICHLOROPROPANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 30 MG/KG |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 52 CENSORED DEATHS 8 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 85 85 184 233 239 251 294 297 307 310 |
| 311 325 330 331 331 336 336 336 345 345 |
| 345 345 345 352 354 361 367 367 371 371 |
| 371 371 381 385 385 397 399 400 402 407 |
| 408 412 416 416 422 423 424 434 441 441 |
| 451 464 |
| CENSORED DEATHS |
| 463 463 465 465 465 465 465 465 |
| |
==================================================================================
1,2,3-TRICHLOROPROPANE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 736 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 98.3 94.7 92.6 82.6 74.5 62.4 |
| | |
| | |
|3 MG/KG | 100.0 100.0 100.0 100.0 100.0 94.6 90.4 84.3 82.2 61.7 |
| | |
| | |
|10 MG/KG | 100.0 100.0 98.3 98.3 93.3 86.4 70.7 51.0 33.4 15.7 |
| | |
| | |
|30 MG/KG | 96.7 96.7 90.0 56.7 21.7 0.0 0.0 0.0 0.0 0.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 3 MG/KG 10 MG/KG 30 MG/KG |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 62.4% 61.7% 15.7% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=1.000N P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 604.2 624.8 572.6 350.8 |
|NATURAL DEATHS (C) | (20.9) (22.6) (15.3) (10.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 648.9 654.1 579.9 365.9 |
|(STANDARD ERROR) | (14.7) (14.8) (14.6) (10.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
1,2,3-TRICHLOROPROPANE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
3 MG/KG = 2
10 MG/KG = 3
30 MG/KG = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 3 4 1 2
| 3 4 1 4 3 1 1 2 2
| 44 3 3 1 122
| 3 3
90 + 4 4 3 3 3 1 1 2
| 444 112 2
| 44 3 3 11 2 2
| 4 4 11 2 2
80 + 33 1 1 22
| 44 3 3 1 1
| 4 4 33 3 1 122
| 4 4 1 1
P 70 + 44 3 3 12 1
E | 4 4 22
R | 33 22 2
C | 44 33
E 60 + 3 3
N |
T | 33
| 44
S 50 + 33
U | 33
R |
V |
I 40 + 44 3 3
V | 33
A | 333
L | 44 33
30 + 444 3 3
|
| 4 4
|
20 + 44
| 44
|
|
10 +
|
|
|
0 + 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 16 obs hidden.
1,2,3-TRICHLOROPROPANE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
3 MG/KG = 2
10 MG/KG = 3
30 MG/KG = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 4 3 12
| 4 4 3 3 12 1221
| 4 4 3 3 21 2 1
| 4 44 33 3 2 1 21
90 + 4 4 2 2
| 444 3 3 3 1 2 212
| 4 4 2 2
| 4 4 1 1 22
80 + 44 33 1 1 22
| 3 3 11 2 2
| 3 3 1 1 22
| 1 1 2 2
P 70 + 4 4 3 3 1 1
E | 333 1 1
R | 112
C | 44 33 12 21
E 60 + 333
N | 444 3 3
T | 33
|
S 50 +
U | 4 4 33
R | 3 3
V | 4 4 33
I 40 + 33
V | 44
A | 44
L | 3 33
30 + 44 33
| 44 3 3
| 33
| 44 333
20 + 44 33
| 4 4
| 4 4 3 3
|
10 +
|
|
|
0 + 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 18 obs hidden.
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