TDMS Study 05114-02 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
HEXACHLOROCYCLOPENTADIENE (HCCPD)
NTP Experiment-Test: 05114-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:54
Facility: Battelle Northwest
Chemical CAS #: 77-47-4
Lock Date: 02/06/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2 PP
M
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Dead 10 8 8 13
Moribund 8 10 11 15
Accident 1 1 1
Survivors
Terminal Sacrifice 31 32 30 21
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (56) (48) (50) (60)
Serosa, Inflammation, Subacute 1 (2%)
Intestine Large, Colon (59) (49) (50) (59)
Inflammation, Suppurative 2 (3%)
Arteriole, Inflammation, Subacute 1 (2%)
Intestine Small, Jejunum (59) (50) (50) (59)
Inflammation, Suppurative 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 2 (4%) 1 (2%)
Intestine Small, Ileum (59) (50) (50) (59)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Liver (59) (60) (60) (60)
Angiectasis 2 (3%)
Bacterium 1 (2%)
Congestion 1 (2%)
Cytoplasmic Alteration 1 (2%) 2 (3%)
Cytoplasmic Alteration, Focal 2 (3%)
Focal Cellular Change 1 (2%) 2 (3%) 1 (2%)
Hematopoietic Cell Proliferation 3 (5%) 2 (3%) 6 (10%)
Hyperplasia, Nodular 2 (3%) 1 (2%)
Infiltration Cellular, Lymphocyte 2 (3%) 3 (5%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Necrotizing 1 (2%)
Inflammation, Subacute 5 (8%) 2 (3%) 2 (3%) 8 (13%)
Inflammation, Suppurative 1 (2%)
Mineralization 1 (2%)
Necrosis, Acute 1 (2%) 2 (3%) 1 (2%)
Pigmentation 1 (2%)
Centrilobular, Necrosis 1 (2%)
Serosa, Inflammation, Suppurative 1 (2%)
Mesentery (7) (4) (6) (3)
Inflammation, Suppurative 1 (14%) 1 (17%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2 PP
M
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Necrosis 4 (57%) 1 (25%) 5 (83%) 3 (100%)
Pancreas (59) (50) (50) (60)
Amyloid Deposition 1 (2%)
Inflammation, Subacute 1 (2%)
Inflammation, Suppurative 2 (4%) 3 (5%)
Acinar Cell, Hypoplasia 1 (2%)
Stomach, Forestomach (59) (60) (60) (60)
Hyperkeratosis 3 (5%) 1 (2%) 5 (8%)
Hyperplasia, Squamous 1 (2%) 1 (2%) 3 (5%)
Serosa, Fibrosis 1 (2%)
Serosa, Inflammation, Suppurative 1 (2%)
Stomach, Glandular (59) (60) (60) (60)
Hemorrhage 1 (2%)
Hyperplasia 2 (3%)
Mineralization 1 (2%) 2 (3%)
Necrosis 2 (3%) 1 (2%) 2 (3%) 2 (3%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (59) (50) (50) (60)
Arteriole, Inflammation, Subacute 1 (2%)
Atrium, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (59) (50) (50) (60)
Amyloid Deposition 1 (2%)
Hyperplasia 1 (2%)
Mineralization 1 (2%)
Adrenal Medulla (58) (50) (50) (59)
Amyloid Deposition 1 (2%)
Pituitary Gland (59) (49) (48) (60)
Congestion 1 (2%)
Cyst 1 (2%)
Hyperplasia 5 (10%) 7 (15%) 3 (5%)
Hypertrophy 4 (7%)
Inflammation, Suppurative 1 (2%)
Thyroid Gland (59) (50) (50) (60)
Cyst 1 (2%)
Inflammation, Subacute 1 (2%)
Follicular Cell, Hyperplasia 9 (15%) 14 (28%) 16 (32%) 14 (23%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2 PP
M
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (59) (52) (52) (60)
Angiectasis 1 (2%)
Cyst 8 (14%) 18 (35%) 13 (25%) 10 (17%)
Hemorrhage 1 (2%)
Inflammation, Subacute 1 (2%) 1 (2%)
Inflammation, Suppurative 3 (6%) 6 (12%) 17 (28%)
Mineralization 1 (2%)
Pigmentation 1 (2%)
Granulosa Cell, Hyperplasia 1 (2%)
Uterus (59) (50) (51) (60)
Angiectasis 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Inflammation, Suppurative 1 (2%) 2 (4%) 4 (7%)
Endometrium, Hyperplasia 10 (17%) 7 (14%) 7 (14%) 5 (8%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (50) (50) (60)
Hyperplasia, Neutrophil 1 (2%)
Lymph Node (7) (8) (5) (5)
Iliac, Hyperplasia, Lymphoid 1 (20%)
Renal, Congestion 1 (13%)
Renal, Hyperplasia, Lymphoid 1 (13%) 1 (20%)
Renal, Inflammation, Suppurative 1 (20%)
Lymph Node, Bronchial (57) (60) (60) (60)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 2 (3%) 4 (7%) 2 (3%)
Hyperplasia, Plasma Cell 1 (2%)
Inflammation, Suppurative 1 (2%)
Lymph Node, Mandibular (50) (44) (47) (57)
Hyperplasia, Lymphoid 2 (4%) 7 (12%)
Hyperplasia, Mast Cell 1 (2%)
Lymph Node, Mesenteric (59) (49) (48) (60)
Congestion 1 (2%)
Hyperplasia, Lymphoid 6 (10%) 3 (6%) 5 (10%) 2 (3%)
Inflammation, Suppurative 1 (2%)
Thrombosis 1 (2%)
Lymph Node, Mediastinal (59) (48) (48) (60)
Hyperplasia, Lymphoid 1 (2%) 2 (4%) 4 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2 PP
M
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Plasma Cell 1 (2%)
Inflammation, Suppurative 1 (2%) 2 (4%) 3 (5%)
Pigmentation 1 (2%)
Spleen (59) (50) (50) (60)
Developmental Malformation 1 (2%)
Hematopoietic Cell Proliferation 3 (5%) 6 (12%) 7 (14%) 17 (28%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 6 (10%) 4 (8%) 6 (12%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Capsule, Inflammation, Subacute 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (58) (47) (44) (53)
Duct, Dilatation 1 (2%)
Skin (59) (50) (49) (59)
Alopecia 2 (3%) 1 (2%) 2 (4%)
Hemorrhage, Acute 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Subcutaneous Tissue, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (59) (50) (50) (60)
Developmental Malformation 1 (2%) 1 (2%)
Fibrous Osteodystrophy 1 (2%)
Fracture 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (59) (50) (50) (60)
Bacterium 1 (2%)
Compression 1 (2%)
Inflammation, Suppurative 1 (2%)
Mineralization 12 (20%) 8 (16%) 4 (8%) 7 (12%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (58) (60) (60) (59)
Bacterium 1 (2%)
Congestion 2 (3%) 1 (2%)
Hyperplasia, Macrophage 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%) 4 (7%) 3 (5%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2 PP
M
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Subacute 1 (2%) 1 (2%) 2 (3%)
Inflammation, Suppurative 1 (2%) 2 (3%)
Alveolar Epithelium, Hyperplasia 1 (2%) 2 (3%) 1 (2%) 2 (3%)
Mucosa, Pigmentation 31 (52%) 54 (92%)
Pleura, Inflammation, Suppurative 2 (3%)
Nose (59) (60) (60) (57)
Inflammation, Subacute 1 (2%)
Inflammation, Suppurative 4 (7%) 1 (2%) 3 (5%) 48 (84%)
Mucosa, Pigmentation 44 (73%) 58 (97%) 50 (88%)
Trachea (59) (60) (58) (57)
Inflammation, Suppurative 2 (4%)
Mucosa, Pigmentation 6 (10%) 53 (91%) 52 (91%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1) (2)
Atrophy 1 (100%)
Cornea, Edema 1 (50%)
Cornea, Hyperplasia 1 (50%)
Cornea, Inflammation, Suppurative 1 (100%)
Harderian Gland (7) (6) (4) (2)
Cyst 1 (14%)
Inflammation, Suppurative 1 (14%) 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (50) (50) (60)
Amyloid Deposition 1 (2%) 1 (2%)
Bacterium 1 (2%)
Casts 2 (3%) 2 (4%) 1 (2%) 1 (2%)
Congestion 1 (2%)
Cyst 1 (2%)
Infiltration Cellular, Lymphocyte 2 (3%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Subacute 1 (2%) 1 (2%) 2 (4%) 2 (3%)
Metaplasia, Osseous 1 (2%) 1 (2%)
Mineralization 1 (2%)
Nephropathy, Chronic 1 (2%) 1 (2%) 2 (3%)
Pelvis, Dilatation 2 (3%)
Renal Tubule, Degeneration, Hyaline 2 (4%)
Urinary Bladder (58) (50) (50) (58)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2 PP
M
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Infiltration Cellular, Lymphocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.01 PPM 0.05 PPM 0.2 PPM 0.2 PPM 0.2 PPM
SE33 SE65
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 90 60 60 60 80 50
Scheduled Sacrifice 40 10 10 10 30
Early Deaths
Moribund 8 6 3 9 7 6
Dead 6 9 5 7 7 10
Accident 1 2 1 1
Survivors
Terminal Sacrifice 35 33 42 34 35 33
Animals Examined Microscopically 90 60 60 60 80 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (80) (17) (8) (59) (20)
Congestion 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Suppurative 1 (1%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Jejunum (80) (18) (9) (60) (20)
Congestion 1 (2%)
Inflammation, Chronic 1 (2%)
Epithelium, Hyperplasia 1 (6%)
Peyer's Patch, Hyperplasia, Lymphoid 2 (3%) 3 (5%)
Intestine Small, Ileum (79) (19) (9) (60) (20)
Congestion 1 (2%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (1%) 1 (11%)
Liver (80) (42) (47) (60) (21)
Angiectasis 1 (2%) 1 (2%)
Basophilic Focus 1 (1%)
Cyst 1 (1%) 1 (2%) 1 (2%)
Cytoplasmic Alteration 1 (1%) 2 (4%) 4 (7%) 4 (19%)
Fatty Change 1 (1%)
Fibrosis 1 (2%)
Focal Cellular Change 1 (1%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Nodular 1 (1%) 2 (4%)
Infarct 1 (1%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (1%) 1 (2%)
Inflammation, Necrotizing 1 (1%)
Inflammation, Subacute 4 (5%) 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (1%)
Mineralization 1 (2%)
Necrosis, Acute 1 (1%) 1 (2%) 2 (3%)
Mesentery (4) (5) (2) (2)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.01 PPM 0.05 PPM 0.2 PPM 0.2 PPM 0.2 PPM
SE33 SE65
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Congestion 1 (20%) 1 (50%)
Inflammation, Suppurative 1 (20%)
Necrosis 1 (25%) 1 (20%) 1 (50%)
Fat, Hemorrhage 1 (25%)
Fat, Necrosis 1 (25%) 2 (40%) 1 (50%) 1 (50%)
Pancreas (79) (18) (8) (60) (20)
Inflammation, Subacute 1 (1%)
Duct, Cyst 1 (1%) 1 (6%)
Stomach, Forestomach (80) (29) (22) (60) (20)
Congestion 1 (5%)
Cyst 1 (5%)
Hyperkeratosis 2 (7%) 1 (5%) 4 (7%)
Hyperplasia 1 (5%)
Stomach, Glandular (79) (26) (18) (60) (20)
Congestion 1 (5%)
Mineralization 1 (1%) 2 (3%)
Necrosis 3 (4%) 1 (4%)
Tooth (2) (1) (2) (1) (1)
Developmental Malformation 2 (100%) 1 (100%) 2 (100%) 1 (100%)
Inflammation, Suppurative 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (80) (17) (8) (60) (20)
Inflammation, Subacute 1 (6%)
Arteriole, Mineralization 1 (2%)
Atrium, Thrombosis 1 (1%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (79) (17) (8) (60) (20)
Hyperplasia 1 (1%) 1 (2%)
Thyroid Gland (87) (19) (12) (60) (67) (45)
Crystals 1 (2%)
Cyst 2 (3%)
Follicular Cell, Hyperplasia 4 (5%) 2 (11%) 2 (17%) 5 (8%) 2 (3%) 4 (9%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.01 PPM 0.05 PPM 0.2 PPM 0.2 PPM 0.2 PPM
SE33 SE65
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (79) (17) (8) (60) (20)
Inflammation, Chronic 1 (2%)
Inflammation, Granulomatous 1 (1%) 1 (2%)
Serosa, Inflammation, Suppurative 1 (6%)
Penis (4) (3) (1) (3)
Concretion 2 (67%) 1 (33%)
Hemorrhage, Acute 1 (33%)
Inflammation, Suppurative 2 (50%) 1 (33%) 1 (100%) 2 (67%)
Preputial Gland (9) (5) (4) (4)
Inflammation, Granulomatous 1 (11%)
Inflammation, Suppurative 2 (22%) 1 (20%) 1 (25%)
Duct, Dilatation 5 (56%) 3 (60%) 3 (75%) 3 (75%)
Prostate (80) (17) (8) (60) (20)
Inflammation, Suppurative 1 (1%) 1 (6%)
Seminal Vesicle (80) (18) (9) (60) (20)
Dilatation 1 (1%) 1 (6%) 1 (11%) 1 (2%)
Hemorrhage 1 (1%)
Testes (80) (18) (9) (60) (20)
Atrophy 2 (3%) 1 (2%) 1 (5%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (80) (17) (8) (60) (59) (35)
Hyperplasia 1 (1%) 2 (3%)
Lymph Node (1) (5) (3) (2)
Congestion 1 (20%)
Deep Cervical, Hematopoietic Cell
Proliferation 1 (50%)
Iliac, Hyperplasia, Lymphoid 1 (33%)
Inguinal, Hyperplasia, Lymphoid 1 (20%)
Renal, Hyperplasia, Lymphoid 2 (67%)
Lymph Node, Mandibular (60) (13) (3) (52) (15)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 5 (10%)
Lymph Node, Mesenteric (78) (22) (13) (59) (20)
Congestion 1 (1%) 2 (9%) 3 (23%) 3 (5%)
Hematopoietic Cell Proliferation 1 (8%) 1 (2%)
Hemorrhage 2 (3%) 1 (5%) 2 (3%)
Hyperplasia, Lymphoid 4 (5%) 1 (5%) 3 (23%) 7 (12%) 1 (5%)
Inflammation, Suppurative 1 (8%)
Spleen (80) (18) (13) (60) (20)
Hematopoietic Cell Proliferation 2 (3%) 1 (6%) 3 (23%) 3 (5%)
Hyperplasia, Lymphoid 3 (23%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.01 PPM 0.05 PPM 0.2 PPM 0.2 PPM 0.2 PPM
SE33 SE65
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (80) (18) (11) (60) (68) (46)
Alopecia 2 (3%) 1 (6%) 1 (9%)
Edema 1 (2%)
Hyperkeratosis 1 (9%)
Inflammation, Necrotizing 1 (6%)
Inflammation, Suppurative 4 (5%) 2 (11%) 2 (18%)
Prepuce, Inflammation, Suppurative 1 (1%) 1 (9%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (80) (16) (9) (60) (59) (35)
Arthrosis 1 (11%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (80) (17) (8) (60) (20)
Compression 1 (1%)
Inflammation, Subacute 1 (2%)
Inflammation, Suppurative 1 (2%)
Mineralization 17 (21%) 1 (13%) 15 (25%) 2 (10%)
Cerebellum, Infarct 1 (6%)
Spinal Cord (1) (1)
Hemorrhage, Acute 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (89) (60) (60) (60) (78) (49)
Congestion 1 (1%) 3 (5%) 1 (2%) 2 (3%) 4 (5%) 2 (4%)
Hemorrhage 1 (2%) 1 (2%)
Hemorrhage, Multifocal 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Infiltration Cellular, Histiocyte 1 (1%) 1 (2%) 1 (1%)
Inflammation, Subacute 1 (1%) 1 (2%) 1 (2%) 3 (5%) 2 (3%) 2 (4%)
Inflammation, Suppurative 4 (7%)
Metaplasia, Osseous 1 (2%)
Pigmentation 1 (1%)
Alveolar Epithelium, Hyperplasia 1 (2%) 5 (8%) 6 (10%) 5 (6%) 2 (4%)
Alveolar Epithelium, Inflammation, Subacute 1 (2%)
Arteriole, Bacterium 1 (2%)
Arteriole, Inflammation, Suppurative 1 (2%)
Artery, Inflammation, Subacute 1 (2%)
Bronchiole, Hyperplasia 1 (1%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.01 PPM 0.05 PPM 0.2 PPM 0.2 PPM 0.2 PPM
SE33 SE65
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Interstitium, Inflammation 1 (1%)
Mucosa, Pigmentation 2 (3%) 49 (82%) 55 (92%) 74 (95%) 45 (92%)
Pleura, Inflammation, Suppurative 1 (1%)
Nose (90) (60) (60) (60) (80) (49)
Hemorrhage, Acute 1 (1%)
Inflammation, Subacute 1 (1%) 1 (2%)
Inflammation, Suppurative 2 (3%) 46 (77%) 10 (13%) 17 (35%)
Mucosa, Pigmentation 52 (87%) 60 (100%) 54 (90%) 80 (100%) 46 (94%)
Trachea (90) (60) (60) (60) (80) (49)
Inflammation, Suppurative 2 (3%)
Mucosa, Pigmentation 29 (48%) 58 (97%) 58 (97%) 80 (100%) 48 (98%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (81) (22) (12) (60) (20)
Casts 1 (1%)
Cyst 1 (1%) 2 (9%) 3 (5%)
Dilatation 3 (4%)
Hydronephrosis 1 (1%) 1 (5%)
Hypertrophy 1 (1%)
Inflammation, Chronic 1 (1%) 2 (17%) 1 (2%)
Inflammation, Subacute 5 (6%) 2 (3%) 1 (5%)
Inflammation, Suppurative 3 (4%) 2 (9%)
Metaplasia, Osseous 1 (5%) 1 (2%)
Mineralization 1 (5%) 4 (7%)
Nephropathy, Chronic 2 (2%) 1 (2%)
Polycystic Kidney 1 (1%)
Pelvis, Dilatation 6 (7%) 4 (18%) 4 (33%) 2 (3%)
Renal Tubule, Cytoplasmic Alteration 1 (1%) 1 (5%)
Renal Tubule, Degeneration 2 (9%) 1 (2%)
Urethra (1)
Concretion 1 (100%)
Urinary Bladder (80) (18) (17) (60) (20)
Concretion 1 (1%) 1 (6%)
Dilatation 8 (10%) 5 (28%) 10 (59%) 4 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.5 PPM 0.5 PPM
SE26 SE42
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 90 70
Scheduled Sacrifice 40 20
Early Deaths
Dead 4 7
Moribund 5 10
Survivors
Terminal Sacrifice 41 33
Animals Examined Microscopically 90 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (20) (10)
Congestion 1 (5%)
Stomach, Forestomach (20) (10)
Congestion 1 (5%)
Stomach, Glandular (20) (10)
Congestion 1 (5%)
Inflammation, Subacute 1 (10%)
Tooth (1) (3)
Developmental Malformation 1 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Thyroid Gland (79) (50)
Follicular Cell, Hyperplasia 7 (9%) 15 (30%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.5 PPM 0.5 PPM
SE26 SE42
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Testes (20) (10)
Atrophy 1 (5%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Bronchial (87) (66)
Hyperplasia, Lymphoid 1 (1%) 7 (11%)
Lymph Node, Mediastinal (75) (53)
Hyperplasia, Lymphoid 5 (9%)
Thymus (78) (50)
Cyst 1 (1%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (68) (46)
Alopecia 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (20) (10)
Mineralization 2 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (90) (70)
Inflammation, Subacute 4 (6%)
Lung (89) (70)
Bronchiectasis 2 (3%)
Congestion 1 (1%) 1 (1%)
Hyperplasia, Macrophage 2 (2%)
Inflammation, Subacute 5 (6%) 7 (10%)
Inflammation, Suppurative 1 (1%) 23 (33%)
Mineralization 1 (1%)
Alveolar Epithelium, Hyperplasia 5 (6%) 5 (7%)
Mucosa, Pigmentation 85 (96%) 49 (70%)
Nose (90) (70)
Inflammation, Suppurative 21 (23%) 39 (56%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:54
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.5 PPM 0.5 PPM
SE26 SE42
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Mucosa, Pigmentation 60 (67%) 38 (54%)
Trachea (87) (70)
Inflammation, Subacute 7 (10%)
Inflammation, Suppurative 2 (2%) 14 (20%)
Mucosa, Pigmentation 86 (99%) 40 (57%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (20) (10)
Inflammation, Subacute 3 (15%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------