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TDMS Study 05114-02 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)


NTP Experiment-Test: 05114-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:54




       Facility:  Battelle Northwest

       Chemical CAS #:  77-47-4

       Lock Date:  02/06/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05114-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.01 PPM     0.05 PPM     0.2   PP                                  
                                                                                          M                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Dead                                              10            8            8           13                                     
    Moribund                                           8           10           11           15                                     
    Accident                                           1                         1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           32           30           21                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (56)         (48)         (50)         (60)                                   
      Serosa, Inflammation, Subacute                                                          1 (2%)                                
   Intestine Large, Colon                             (59)         (49)         (50)         (59)                                   
      Inflammation, Suppurative                                                               2 (3%)                                
      Arteriole, Inflammation, Subacute                                          1 (2%)                                             
   Intestine Small, Jejunum                           (59)         (50)         (50)         (59)                                   
      Inflammation, Suppurative                                                  1 (2%)                                             
      Peyer's Patch, Hyperplasia, Lymphoid                          1 (2%)       2 (4%)       1 (2%)                                
   Intestine Small, Ileum                             (59)         (50)         (50)         (59)                                   
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                    1 (2%)                                             
   Liver                                              (59)         (60)         (60)         (60)                                   
      Angiectasis                                      2 (3%)                                                                       
      Bacterium                                                                               1 (2%)                                
      Congestion                                                                              1 (2%)                                
      Cytoplasmic Alteration                           1 (2%)       2 (3%)                                                          
      Cytoplasmic Alteration, Focal                                                           2 (3%)                                
      Focal Cellular Change                                         1 (2%)       2 (3%)       1 (2%)                                
      Hematopoietic Cell Proliferation                              3 (5%)       2 (3%)       6 (10%)                               
      Hyperplasia, Nodular                                          2 (3%)       1 (2%)                                             
      Infiltration Cellular, Lymphocyte                2 (3%)       3 (5%)       1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Necrotizing                                     1 (2%)                                                          
      Inflammation, Subacute                           5 (8%)       2 (3%)       2 (3%)       8 (13%)                               
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mineralization                                                1 (2%)                                                          
      Necrosis, Acute                                  1 (2%)       2 (3%)       1 (2%)                                             
      Pigmentation                                     1 (2%)                                                                       
      Centrilobular, Necrosis                          1 (2%)                                                                       
      Serosa, Inflammation, Suppurative                                                       1 (2%)                                
   Mesentery                                          (7)          (4)          (6)          (3)                                    
      Inflammation, Suppurative                        1 (14%)                   1 (17%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05114-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.01 PPM     0.05 PPM     0.2   PP                                  
                                                                                          M                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Necrosis                                    4 (57%)      1 (25%)      5 (83%)      3 (100%)                              
   Pancreas                                           (59)         (50)         (50)         (60)                                   
      Amyloid Deposition                                                         1 (2%)                                             
      Inflammation, Subacute                                                     1 (2%)                                             
      Inflammation, Suppurative                                                  2 (4%)       3 (5%)                                
      Acinar Cell, Hypoplasia                                                                 1 (2%)                                
   Stomach, Forestomach                               (59)         (60)         (60)         (60)                                   
      Hyperkeratosis                                   3 (5%)       1 (2%)                    5 (8%)                                
      Hyperplasia, Squamous                                         1 (2%)       1 (2%)       3 (5%)                                
      Serosa, Fibrosis                                                                        1 (2%)                                
      Serosa, Inflammation, Suppurative                             1 (2%)                                                          
   Stomach, Glandular                                 (59)         (60)         (60)         (60)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                      2 (3%)                                                                       
      Mineralization                                   1 (2%)                    2 (3%)                                             
      Necrosis                                         2 (3%)       1 (2%)       2 (3%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)         (50)         (50)         (60)                                   
      Arteriole, Inflammation, Subacute                                          1 (2%)                                             
      Atrium, Thrombosis                                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)         (50)         (50)         (60)                                   
      Amyloid Deposition                                                                      1 (2%)                                
      Hyperplasia                                      1 (2%)                                                                       
      Mineralization                                                                          1 (2%)                                
   Adrenal Medulla                                    (58)         (50)         (50)         (59)                                   
      Amyloid Deposition                                                                      1 (2%)                                
   Pituitary Gland                                    (59)         (49)         (48)         (60)                                   
      Congestion                                       1 (2%)                                                                       
      Cyst                                                                                    1 (2%)                                
      Hyperplasia                                                   5 (10%)      7 (15%)      3 (5%)                                
      Hypertrophy                                      4 (7%)                                                                       
      Inflammation, Suppurative                                                               1 (2%)                                
   Thyroid Gland                                      (59)         (50)         (50)         (60)                                   
      Cyst                                             1 (2%)                                                                       
      Inflammation, Subacute                           1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     9 (15%)     14 (28%)     16 (32%)     14 (23%)                               
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05114-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.01 PPM     0.05 PPM     0.2   PP                                  
                                                                                          M                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (59)         (52)         (52)         (60)                                   
      Angiectasis                                                   1 (2%)                                                          
      Cyst                                             8 (14%)     18 (35%)     13 (25%)     10 (17%)                               
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Subacute                           1 (2%)                                 1 (2%)                                
      Inflammation, Suppurative                                     3 (6%)       6 (12%)     17 (28%)                               
      Mineralization                                   1 (2%)                                                                       
      Pigmentation                                                                            1 (2%)                                
      Granulosa Cell, Hyperplasia                                   1 (2%)                                                          
   Uterus                                             (59)         (50)         (51)         (60)                                   
      Angiectasis                                                                1 (2%)                                             
      Hemorrhage                                       1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Inflammation, Suppurative                        1 (2%)                    2 (4%)       4 (7%)                                
      Endometrium, Hyperplasia                        10 (17%)      7 (14%)      7 (14%)      5 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (50)         (50)         (60)                                   
      Hyperplasia, Neutrophil                                       1 (2%)                                                          
   Lymph Node                                         (7)          (8)          (5)          (5)                                    
      Iliac, Hyperplasia, Lymphoid                                               1 (20%)                                            
      Renal, Congestion                                             1 (13%)                                                         
      Renal, Hyperplasia, Lymphoid                                  1 (13%)      1 (20%)                                            
      Renal, Inflammation, Suppurative                                                        1 (20%)                               
   Lymph Node, Bronchial                              (57)         (60)         (60)         (60)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            2 (4%)       2 (3%)       4 (7%)       2 (3%)                                
      Hyperplasia, Plasma Cell                                                   1 (2%)                                             
      Inflammation, Suppurative                                     1 (2%)                                                          
   Lymph Node, Mandibular                             (50)         (44)         (47)         (57)                                   
      Hyperplasia, Lymphoid                            2 (4%)                                 7 (12%)                               
      Hyperplasia, Mast Cell                                                                  1 (2%)                                
   Lymph Node, Mesenteric                             (59)         (49)         (48)         (60)                                   
      Congestion                                                    1 (2%)                                                          
      Hyperplasia, Lymphoid                            6 (10%)      3 (6%)       5 (10%)      2 (3%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
      Thrombosis                                                    1 (2%)                                                          
   Lymph Node, Mediastinal                            (59)         (48)         (48)         (60)                                   
      Hyperplasia, Lymphoid                                         1 (2%)       2 (4%)       4 (7%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05114-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.01 PPM     0.05 PPM     0.2   PP                                  
                                                                                          M                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Plasma Cell                                                   1 (2%)                                             
      Inflammation, Suppurative                                     1 (2%)       2 (4%)       3 (5%)                                
      Pigmentation                                                  1 (2%)                                                          
   Spleen                                             (59)         (50)         (50)         (60)                                   
      Developmental Malformation                                    1 (2%)                                                          
      Hematopoietic Cell Proliferation                 3 (5%)       6 (12%)      7 (14%)     17 (28%)                               
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            6 (10%)      4 (8%)       6 (12%)                                            
      Inflammation, Suppurative                        1 (2%)                                 1 (2%)                                
      Capsule, Inflammation, Subacute                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)         (47)         (44)         (53)                                   
      Duct, Dilatation                                                           1 (2%)                                             
   Skin                                               (59)         (50)         (49)         (59)                                   
      Alopecia                                         2 (3%)       1 (2%)       2 (4%)                                             
      Hemorrhage, Acute                                             1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Mineralization                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (59)         (50)         (50)         (60)                                   
      Developmental Malformation                                                 1 (2%)       1 (2%)                                
      Fibrous Osteodystrophy                           1 (2%)                                                                       
      Fracture                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)         (50)         (50)         (60)                                   
      Bacterium                                                                               1 (2%)                                
      Compression                                                                1 (2%)                                             
      Inflammation, Suppurative                                                               1 (2%)                                
      Mineralization                                  12 (20%)      8 (16%)      4 (8%)       7 (12%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (58)         (60)         (60)         (59)                                   
      Bacterium                                                                               1 (2%)                                
      Congestion                                       2 (3%)       1 (2%)                                                          
      Hyperplasia, Macrophage                                       1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                1 (2%)       4 (7%)       3 (5%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05114-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.01 PPM     0.05 PPM     0.2   PP                                  
                                                                                          M                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Infiltration Cellular, Histiocyte                                                       1 (2%)                                
      Inflammation, Subacute                                        1 (2%)       1 (2%)       2 (3%)                                
      Inflammation, Suppurative                        1 (2%)                                 2 (3%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)       2 (3%)       1 (2%)       2 (3%)                                
      Mucosa, Pigmentation                                                      31 (52%)     54 (92%)                               
      Pleura, Inflammation, Suppurative                                                       2 (3%)                                
   Nose                                               (59)         (60)         (60)         (57)                                   
      Inflammation, Subacute                                                     1 (2%)                                             
      Inflammation, Suppurative                        4 (7%)       1 (2%)       3 (5%)      48 (84%)                               
      Mucosa, Pigmentation                                         44 (73%)     58 (97%)     50 (88%)                               
   Trachea                                            (59)         (60)         (58)         (57)                                   
      Inflammation, Suppurative                                                               2 (4%)                                
      Mucosa, Pigmentation                                          6 (10%)     53 (91%)     52 (91%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)          (2)                                                 
      Atrophy                                                       1 (100%)                                                        
      Cornea, Edema                                                              1 (50%)                                            
      Cornea, Hyperplasia                                                        1 (50%)                                            
      Cornea, Inflammation, Suppurative                1 (100%)                                                                     
   Harderian Gland                                    (7)          (6)          (4)          (2)                                    
      Cyst                                             1 (14%)                                                                      
      Inflammation, Suppurative                        1 (14%)                                1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (50)         (50)         (60)                                   
      Amyloid Deposition                               1 (2%)                    1 (2%)                                             
      Bacterium                                                                               1 (2%)                                
      Casts                                            2 (3%)       2 (4%)       1 (2%)       1 (2%)                                
      Congestion                                                                              1 (2%)                                
      Cyst                                             1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                2 (3%)       1 (2%)                    1 (2%)                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Subacute                           1 (2%)       1 (2%)       2 (4%)       2 (3%)                                
      Metaplasia, Osseous                                           1 (2%)       1 (2%)                                             
      Mineralization                                                             1 (2%)                                             
      Nephropathy, Chronic                             1 (2%)       1 (2%)                    2 (3%)                                
      Pelvis, Dilatation                               2 (3%)                                                                       
      Renal Tubule, Degeneration, Hyaline                           2 (4%)                                                          
   Urinary Bladder                                    (58)         (50)         (50)         (58)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05114-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.01 PPM     0.05 PPM     0.2   PP                                  
                                                                                          M                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05114-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.01 PPM     0.05 PPM     0.2  PPM     0.2  PPM     0.2  PPM        
                                                                                                       SE33         SE65            
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          90           60           60           60           80           50           
  Scheduled Sacrifice                                 40           10           10           10           30                        
  Early Deaths                                                                                                                      
    Moribund                                           8            6            3            9            7            6           
    Dead                                               6            9            5            7            7           10           
    Accident                                           1            2                                      1            1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           33           42           34           35           33           
  Animals Examined Microscopically                    90           60           60           60           80           50           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (80)         (17)         (8)          (59)         (20)                      
      Congestion                                                                              1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
      Inflammation, Suppurative                        1 (1%)                                                                       
      Peyer's Patch, Hyperplasia, Lymphoid                                                    1 (2%)                                
   Intestine Small, Jejunum                           (80)         (18)         (9)          (60)         (20)                      
      Congestion                                                                              1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Epithelium, Hyperplasia                                       1 (6%)                                                          
      Peyer's Patch, Hyperplasia, Lymphoid             2 (3%)                                 3 (5%)                                
   Intestine Small, Ileum                             (79)         (19)         (9)          (60)         (20)                      
      Congestion                                                                              1 (2%)                                
      Peyer's Patch, Hyperplasia, Lymphoid             1 (1%)                    1 (11%)                                            
   Liver                                              (80)         (42)         (47)         (60)         (21)                      
      Angiectasis                                                   1 (2%)       1 (2%)                                             
      Basophilic Focus                                 1 (1%)                                                                       
      Cyst                                             1 (1%)       1 (2%)       1 (2%)                                             
      Cytoplasmic Alteration                           1 (1%)                    2 (4%)       4 (7%)       4 (19%)                  
      Fatty Change                                     1 (1%)                                                                       
      Fibrosis                                                      1 (2%)                                                          
      Focal Cellular Change                            1 (1%)       1 (2%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hyperplasia, Nodular                             1 (1%)                    2 (4%)                                             
      Infarct                                          1 (1%)       1 (2%)                    1 (2%)                                
      Inflammation, Chronic                            1 (1%)       1 (2%)                                                          
      Inflammation, Necrotizing                        1 (1%)                                                                       
      Inflammation, Subacute                           4 (5%)       1 (2%)                    1 (2%)                                
      Inflammation, Suppurative                        1 (1%)                                                                       
      Mineralization                                                                          1 (2%)                                
      Necrosis, Acute                                  1 (1%)       1 (2%)                    2 (3%)                                
   Mesentery                                          (4)          (5)          (2)          (2)                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05114-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.01 PPM     0.05 PPM     0.2  PPM     0.2  PPM     0.2  PPM        
                                                                                                       SE33         SE65            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Congestion                                                    1 (20%)      1 (50%)                                            
      Inflammation, Suppurative                                     1 (20%)                                                         
      Necrosis                                         1 (25%)      1 (20%)                   1 (50%)                               
      Fat, Hemorrhage                                  1 (25%)                                                                      
      Fat, Necrosis                                    1 (25%)      2 (40%)      1 (50%)      1 (50%)                               
   Pancreas                                           (79)         (18)         (8)          (60)         (20)                      
      Inflammation, Subacute                           1 (1%)                                                                       
      Duct, Cyst                                       1 (1%)       1 (6%)                                                          
   Stomach, Forestomach                               (80)         (29)         (22)         (60)         (20)                      
      Congestion                                                                                           1 (5%)                   
      Cyst                                                                       1 (5%)                                             
      Hyperkeratosis                                                2 (7%)       1 (5%)       4 (7%)                                
      Hyperplasia                                                                1 (5%)                                             
   Stomach, Glandular                                 (79)         (26)         (18)         (60)         (20)                      
      Congestion                                                                                           1 (5%)                   
      Mineralization                                   1 (1%)                                 2 (3%)                                
      Necrosis                                         3 (4%)       1 (4%)                                                          
   Tooth                                                           (2)          (1)          (2)          (1)          (1)          
      Developmental Malformation                                    2 (100%)     1 (100%)     2 (100%)                  1 (100%)    
      Inflammation, Suppurative                                     1 (50%)                                1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (80)         (17)         (8)          (60)         (20)                      
      Inflammation, Subacute                                        1 (6%)                                                          
      Arteriole, Mineralization                                                               1 (2%)                                
      Atrium, Thrombosis                               1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (79)         (17)         (8)          (60)         (20)                      
      Hyperplasia                                      1 (1%)                                 1 (2%)                                
   Thyroid Gland                                      (87)         (19)         (12)         (60)         (67)         (45)         
      Crystals                                                                                                          1 (2%)      
      Cyst                                                                                                 2 (3%)                   
      Follicular Cell, Hyperplasia                     4 (5%)       2 (11%)      2 (17%)      5 (8%)       2 (3%)       4 (9%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05114-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.01 PPM     0.05 PPM     0.2  PPM     0.2  PPM     0.2  PPM        
                                                                                                       SE33         SE65            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (79)         (17)         (8)          (60)         (20)                      
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Granulomatous                      1 (1%)                                 1 (2%)                                
      Serosa, Inflammation, Suppurative                             1 (6%)                                                          
   Penis                                              (4)          (3)          (1)          (3)                                    
      Concretion                                                    2 (67%)                   1 (33%)                               
      Hemorrhage, Acute                                             1 (33%)                                                         
      Inflammation, Suppurative                        2 (50%)      1 (33%)      1 (100%)     2 (67%)                               
   Preputial Gland                                    (9)          (5)          (4)          (4)                                    
      Inflammation, Granulomatous                      1 (11%)                                                                      
      Inflammation, Suppurative                        2 (22%)      1 (20%)      1 (25%)                                            
      Duct, Dilatation                                 5 (56%)      3 (60%)      3 (75%)      3 (75%)                               
   Prostate                                           (80)         (17)         (8)          (60)         (20)                      
      Inflammation, Suppurative                        1 (1%)       1 (6%)                                                          
   Seminal Vesicle                                    (80)         (18)         (9)          (60)         (20)                      
      Dilatation                                       1 (1%)       1 (6%)       1 (11%)      1 (2%)                                
      Hemorrhage                                       1 (1%)                                                                       
   Testes                                             (80)         (18)         (9)          (60)         (20)                      
      Atrophy                                          2 (3%)                                 1 (2%)       1 (5%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (80)         (17)         (8)          (60)         (59)         (35)         
      Hyperplasia                                      1 (1%)                                 2 (3%)                                
   Lymph Node                                         (1)          (5)          (3)          (2)                                    
      Congestion                                                    1 (20%)                                                         
      Deep Cervical, Hematopoietic Cell                                                                                             
          Proliferation                                                                       1 (50%)                               
      Iliac, Hyperplasia, Lymphoid                                               1 (33%)                                            
      Inguinal, Hyperplasia, Lymphoid                               1 (20%)                                                         
      Renal, Hyperplasia, Lymphoid                                               2 (67%)                                            
   Lymph Node, Mandibular                             (60)         (13)         (3)          (52)         (15)                      
      Congestion                                       1 (2%)                                                                       
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hyperplasia                                                                             1 (2%)                                
      Hyperplasia, Lymphoid                                                                   5 (10%)                               
   Lymph Node, Mesenteric                             (78)         (22)         (13)         (59)         (20)                      
      Congestion                                       1 (1%)       2 (9%)       3 (23%)      3 (5%)                                
      Hematopoietic Cell Proliferation                                           1 (8%)       1 (2%)                                
      Hemorrhage                                       2 (3%)       1 (5%)                    2 (3%)                                
      Hyperplasia, Lymphoid                            4 (5%)       1 (5%)       3 (23%)      7 (12%)      1 (5%)                   
      Inflammation, Suppurative                                                  1 (8%)                                             
   Spleen                                             (80)         (18)         (13)         (60)         (20)                      
      Hematopoietic Cell Proliferation                 2 (3%)       1 (6%)       3 (23%)      3 (5%)                                
      Hyperplasia, Lymphoid                                                      3 (23%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05114-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.01 PPM     0.05 PPM     0.2  PPM     0.2  PPM     0.2  PPM        
                                                                                                       SE33         SE65            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (80)         (18)         (11)         (60)         (68)         (46)         
      Alopecia                                         2 (3%)       1 (6%)       1 (9%)                                             
      Edema                                                                                   1 (2%)                                
      Hyperkeratosis                                                             1 (9%)                                             
      Inflammation, Necrotizing                                     1 (6%)                                                          
      Inflammation, Suppurative                        4 (5%)       2 (11%)      2 (18%)                                            
      Prepuce, Inflammation, Suppurative               1 (1%)                    1 (9%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (80)         (16)         (9)          (60)         (59)         (35)         
      Arthrosis                                                                  1 (11%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (80)         (17)         (8)          (60)         (20)                      
      Compression                                      1 (1%)                                                                       
      Inflammation, Subacute                                                                  1 (2%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
      Mineralization                                  17 (21%)                   1 (13%)     15 (25%)      2 (10%)                  
      Cerebellum, Infarct                                           1 (6%)                                                          
   Spinal Cord                                        (1)          (1)                                                              
      Hemorrhage, Acute                                             1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (89)         (60)         (60)         (60)         (78)         (49)         
      Congestion                                       1 (1%)       3 (5%)       1 (2%)       2 (3%)       4 (5%)       2 (4%)      
      Hemorrhage                                                                 1 (2%)                                 1 (2%)      
      Hemorrhage, Multifocal                                        1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Infiltration Cellular, Histiocyte                1 (1%)       1 (2%)                                 1 (1%)                   
      Inflammation, Subacute                           1 (1%)       1 (2%)       1 (2%)       3 (5%)       2 (3%)       2 (4%)      
      Inflammation, Suppurative                                                               4 (7%)                                
      Metaplasia, Osseous                                           1 (2%)                                                          
      Pigmentation                                                                                         1 (1%)                   
      Alveolar Epithelium, Hyperplasia                              1 (2%)       5 (8%)       6 (10%)      5 (6%)       2 (4%)      
      Alveolar Epithelium, Inflammation, Subacute                                1 (2%)                                             
      Arteriole, Bacterium                                                                                              1 (2%)      
      Arteriole, Inflammation, Suppurative                          1 (2%)                                                          
      Artery, Inflammation, Subacute                                             1 (2%)                                             
      Bronchiole, Hyperplasia                          1 (1%)                                 1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05114-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.01 PPM     0.05 PPM     0.2  PPM     0.2  PPM     0.2  PPM        
                                                                                                       SE33         SE65            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Interstitium, Inflammation                                                                           1 (1%)                   
      Mucosa, Pigmentation                                          2 (3%)      49 (82%)     55 (92%)     74 (95%)     45 (92%)     
      Pleura, Inflammation, Suppurative                1 (1%)                                                                       
   Nose                                               (90)         (60)         (60)         (60)         (80)         (49)         
      Hemorrhage, Acute                                1 (1%)                                                                       
      Inflammation, Subacute                                                                               1 (1%)       1 (2%)      
      Inflammation, Suppurative                                                  2 (3%)      46 (77%)     10 (13%)     17 (35%)     
      Mucosa, Pigmentation                                         52 (87%)     60 (100%)    54 (90%)     80 (100%)    46 (94%)     
   Trachea                                            (90)         (60)         (60)         (60)         (80)         (49)         
      Inflammation, Suppurative                                                               2 (3%)                                
      Mucosa, Pigmentation                                         29 (48%)     58 (97%)     58 (97%)     80 (100%)    48 (98%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (81)         (22)         (12)         (60)         (20)                      
      Casts                                            1 (1%)                                                                       
      Cyst                                             1 (1%)       2 (9%)                    3 (5%)                                
      Dilatation                                       3 (4%)                                                                       
      Hydronephrosis                                   1 (1%)       1 (5%)                                                          
      Hypertrophy                                      1 (1%)                                                                       
      Inflammation, Chronic                            1 (1%)                    2 (17%)      1 (2%)                                
      Inflammation, Subacute                           5 (6%)                                 2 (3%)       1 (5%)                   
      Inflammation, Suppurative                        3 (4%)       2 (9%)                                                          
      Metaplasia, Osseous                                           1 (5%)                    1 (2%)                                
      Mineralization                                                1 (5%)                    4 (7%)                                
      Nephropathy, Chronic                             2 (2%)                                 1 (2%)                                
      Polycystic Kidney                                1 (1%)                                                                       
      Pelvis, Dilatation                               6 (7%)       4 (18%)      4 (33%)      2 (3%)                                
      Renal Tubule, Cytoplasmic Alteration             1 (1%)                                              1 (5%)                   
      Renal Tubule, Degeneration                                    2 (9%)                    1 (2%)                                
   Urethra                                            (1)                                                                           
      Concretion                                       1 (100%)                                                                     
   Urinary Bladder                                    (80)         (18)         (17)         (60)         (20)                      
      Concretion                                       1 (1%)       1 (6%)                                                          
      Dilatation                                       8 (10%)      5 (28%)     10 (59%)      4 (7%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05114-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.5  PPM     0.5  PPM                                                            
                                                   SE26         SE42                                                                
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          90           70                                                               
  Scheduled Sacrifice                                 40           20                                                               
  Early Deaths                                                                                                                      
    Dead                                               4            7                                                               
    Moribund                                           5           10                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           33                                                               
  Animals Examined Microscopically                    90           70                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (20)         (10)                                                             
      Congestion                                       1 (5%)                                                                       
   Stomach, Forestomach                               (20)         (10)                                                             
      Congestion                                       1 (5%)                                                                       
   Stomach, Glandular                                 (20)         (10)                                                             
      Congestion                                       1 (5%)                                                                       
      Inflammation, Subacute                                        1 (10%)                                                         
   Tooth                                              (1)          (3)                                                              
      Developmental Malformation                       1 (100%)     3 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Thyroid Gland                                      (79)         (50)                                                             
      Follicular Cell, Hyperplasia                     7 (9%)      15 (30%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05114-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.5  PPM     0.5  PPM                                                            
                                                   SE26         SE42                                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Testes                                             (20)         (10)                                                             
      Atrophy                                          1 (5%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Bronchial                              (87)         (66)                                                             
      Hyperplasia, Lymphoid                            1 (1%)       7 (11%)                                                         
   Lymph Node, Mediastinal                            (75)         (53)                                                             
      Hyperplasia, Lymphoid                                         5 (9%)                                                          
   Thymus                                             (78)         (50)                                                             
      Cyst                                             1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (68)         (46)                                                             
      Alopecia                                                      2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (20)         (10)                                                             
      Mineralization                                   2 (10%)      1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (90)         (70)                                                             
      Inflammation, Subacute                                        4 (6%)                                                          
   Lung                                               (89)         (70)                                                             
      Bronchiectasis                                                2 (3%)                                                          
      Congestion                                       1 (1%)       1 (1%)                                                          
      Hyperplasia, Macrophage                          2 (2%)                                                                       
      Inflammation, Subacute                           5 (6%)       7 (10%)                                                         
      Inflammation, Suppurative                        1 (1%)      23 (33%)                                                         
      Mineralization                                                1 (1%)                                                          
      Alveolar Epithelium, Hyperplasia                 5 (6%)       5 (7%)                                                          
      Mucosa, Pigmentation                            85 (96%)     49 (70%)                                                         
   Nose                                               (90)         (70)                                                             
      Inflammation, Suppurative                       21 (23%)     39 (56%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05114-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:54  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.5  PPM     0.5  PPM                                                            
                                                   SE26         SE42                                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Mucosa, Pigmentation                            60 (67%)     38 (54%)                                                         
   Trachea                                            (87)         (70)                                                             
      Inflammation, Subacute                                        7 (10%)                                                         
      Inflammation, Suppurative                        2 (2%)      14 (20%)                                                         
      Mucosa, Pigmentation                            86 (99%)     40 (57%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (20)         (10)                                                             
      Inflammation, Subacute                           3 (15%)                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
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