TDMS Study 05114-02 Pathology Tables
NTP Experiment-Test: 05114-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/19/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:01:42
33 WEEK STOP EXPOSURE EVALUATION
Facility: Battelle Northwest
Chemical CAS #: 77-47-4
Lock Date: 02/06/92
Cage Range: All
Reasons For Removal: 25005 Interval Sacrifice
Removal Date Range: All
Treatment Groups: Include 009 0.2 PPMSE33
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05114-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/19/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:01:42
_____________________________________________________________________________________________________________________
| 2| 4| 2| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 4| 2| 4| 4| 2| 2| 2| 2| 4| 4|
DAY ON TEST | 3| 5| 9| 9| 5| 3| 9| 3| 9| 9| 3| 9| 3| 5| 9| 5| 3| 5| 5| 3| 9| 3| 3| 5| 5|
| 2| 9| 5| 5| 9| 2| 5| 2| 5| 5| 2| 5| 2| 9| 5| 9| 2| 9| 9| 2| 5| 2| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2 PPM | 4| 4| 4| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 9| 9| 9| 0| 1| 1| 2| 2| 3| 3| 3| 3|
SE33 | 3| 4| 5| 3| 5| 1| 2| 4| 5| 1| 4| 1| 3| 2| 3| 5| 4| 1| 4| 2| 3| 1| 2| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + + + M + + + M |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + M + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + M + + M + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M M + + + M + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05114-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/19/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:01:42
_____________________________________________________________________________________________________________________
| 2| 4| 2| 2| 4| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 4| 2| 4| 4| 2| 2| 2| 2| 4| 4|
DAY ON TEST | 3| 5| 9| 9| 5| 3| 9| 3| 9| 9| 3| 9| 3| 5| 9| 5| 3| 5| 5| 3| 9| 3| 3| 5| 5|
| 2| 9| 5| 5| 9| 2| 5| 2| 5| 5| 2| 5| 2| 9| 5| 9| 2| 9| 9| 2| 5| 2| 2| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2 PPM | 4| 4| 4| 5| 5| 6| 6| 6| 6| 7| 7| 8| 8| 9| 9| 9| 0| 1| 1| 2| 2| 3| 3| 3| 3|
SE33 | 3| 4| 5| 3| 5| 1| 2| 4| 5| 1| 4| 1| 3| 2| 3| 5| 4| 1| 4| 2| 3| 1| 2| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M M M M + M M M M + M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05114-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/19/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:01:42
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 4| 4| | |
DAY ON TEST | 9| 3| 9| 5| 5| | |
| 5| 2| 5| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
0.2 PPM | 4| 4| 5| 6| 7| | L |
SE33 | 4| 5| 2| 2| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 20 |
__________________________________________________________________________|____________|
Gallbladder | + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 20 |
__________________________________________________________________________|____________|
Liver | + + + | 20 |
__________________________________________________________________________|____________|
Pancreas | + + + | 20 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 20 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 20 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 20 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 18 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 20 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 20 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + | 20 |
__________________________________________________________________________|____________|
Prostate | + + + | 20 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 20 |
__________________________________________________________________________|____________|
Testes | + + + | 20 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + | 28 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 4
NTP Experiment-Test: 05114-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/19/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:01:42
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 4| 4| | |
DAY ON TEST | 9| 3| 9| 5| 5| | |
| 5| 2| 5| 9| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
0.2 PPM | 4| 4| 5| 6| 7| | L |
SE33 | 4| 5| 2| 2| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 20 |
__________________________________________________________________________|____________|
Spleen | + + + | 20 |
__________________________________________________________________________|____________|
Thymus | + + + | 20 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M | 3 |
__________________________________________________________________________|____________|
Skin | + + + | 20 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 20 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 20 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + | 30 |
__________________________________________________________________________|____________|
Lung | + + + + | 28 |
Alveolar/Bronchiolar Adenoma | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + | 30 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 30 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 20 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 20 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + | 30 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------