TDMS Study 05114-02 Pathology Tables
NTP Experiment-Test: 05114-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/19/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:56
42 WEEK STOP EXPOSURE EVALUATION
Facility: Battelle Northwest
Chemical CAS #: 77-47-4
Lock Date: 02/06/92
Cage Range: All
Reasons For Removal: 25005 Interval Sacrifice
Removal Date Range: All
Treatment Groups: Include 012 0.5 PPMSE42
Note: Animals arranged according to CID number
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NTP Experiment-Test: 05114-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/19/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:56
__________________________________________________________________________________________________________________________________
| 4| 2| 2| 4| 2| 4| 4| 2| 2| 2| 2| 4| 2| 4| 4| 2| 4| 4| 2| 4| | |
DAY ON TEST | 5| 9| 9| 5| 9| 5| 5| 9| 9| 9| 9| 5| 9| 5| 5| 9| 5| 5| 9| 5| | |
| 8| 5| 5| 8| 5| 8| 8| 5| 5| 5| 5| 8| 5| 8| 8| 5| 8| 8| 5| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 4| 6| 7| 8| 0| 1| 1| 2| 2| 3| 4| 5| 5| | L |
SE42 | 1| 2| 3| 5| 1| 2| 4| 3| 5| 5| 4| 1| 1| 5| 2| 5| 2| 4| 1| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hepatocellular Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + M + | 8 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M + + M + + + + + + + M + + + + | 17 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
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NTP Experiment-Test: 05114-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/19/96
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:25:56
__________________________________________________________________________________________________________________________________
| 4| 2| 2| 4| 2| 4| 4| 2| 2| 2| 2| 4| 2| 4| 4| 2| 4| 4| 2| 4| | |
DAY ON TEST | 5| 9| 9| 5| 9| 5| 5| 9| 9| 9| 9| 5| 9| 5| 5| 9| 5| 5| 9| 5| | |
| 8| 5| 5| 8| 5| 8| 8| 5| 5| 5| 5| 8| 5| 8| 8| 5| 8| 8| 5| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 4| 6| 7| 8| 0| 1| 1| 2| 2| 3| 4| 5| 5| | L |
SE42 | 1| 2| 3| 5| 1| 2| 4| 3| 5| 5| 4| 1| 1| 5| 2| 5| 2| 4| 1| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M + | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 20 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 20 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
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