TDMS Study 05114-02 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
HEXACHLOROCYCLOPENTADIENE (HCCPD)
NTP Experiment-Test: 05114-02 Report: PEIRPT05
Study Type: CHRONIC Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:56
Facility: Battelle Northwest
Chemical CAS #: 77-47-4
Lock Date: 02/06/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2 PP
M
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Dead 10 8 8 13
Moribund 8 10 11 15
Accident 1 1 1
Survivors
Terminal Sacrifice 31 32 30 21
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (59) (49) (50) (59)
Intestine Large, Cecum (59) (50) (50) (59)
Intestine Small, Duodenum (59) (50) (50) (59)
Intestine Small, Jejunum (59) (50) (50) (59)
Adenocarcinoma 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Intestine Small, Ileum (59) (50) (50) (59)
Liver (59) (60) (60) (60)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hemangiosarcoma 1 (2%)
Hepatocellular Carcinoma 4 (7%) 2 (3%) 4 (7%) 1 (2%)
Hepatocellular Adenoma 6 (10%) 10 (17%) 6 (10%) 6 (10%)
Hepatocellular Adenoma, Two 1 (2%)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Mesentery (7) (4) (6) (3)
Fibrosarcoma, Metastatic, Skin 1 (25%)
Hemangiosarcoma 1 (25%)
Histiocytic Sarcoma 1 (14%)
Pancreas (59) (50) (50) (60)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Salivary Glands (59) (50) (50) (60)
Stomach, Forestomach (59) (60) (60) (60)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Squamous Cell Papilloma 1 (2%) 2 (3%)
Stomach, Glandular (59) (60) (60) (60)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Histiocytic Sarcoma 1 (2%)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2 PP
M
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (59) (50) (50) (60)
Hemangiosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (59) (50) (50) (60)
Carcinoma 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Adrenal Medulla (58) (50) (50) (59)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%)
Islets, Pancreatic (59) (50) (49) (60)
Carcinoma 1 (2%)
Pituitary Gland (59) (49) (48) (60)
Adenoma 8 (14%) 3 (6%) 5 (10%) 3 (5%)
Carcinoma 1 (2%) 1 (2%)
Thyroid Gland (59) (50) (50) (60)
Follicular Cell, Adenoma 1 (2%) 1 (2%) 6 (12%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Sarcoma, Metastatic, Skin 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (59) (52) (52) (60)
Adenoma 1 (2%) 2 (4%)
Cystadenoma 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Hemangioma 1 (2%)
Histiocytic Sarcoma 2 (3%)
Teratoma NOS 1 (2%)
Uterus (59) (50) (51) (60)
Adenocarcinoma 1 (2%)
Adenoma 1 (2%) 2 (4%)
Hemangioma 1 (2%) 1 (2%)
Hemangioma, Mild 1 (2%)
Histiocytic Sarcoma 3 (5%) 1 (2%)
Endometrium, Polyp, Moderate 1 (2%)
Endometrium, Polyp Stromal, Moderate 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2 PP
M
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (50) (50) (60)
Hemangiosarcoma 1 (2%)
Lymph Node (7) (8) (5) (5)
Lymph Node, Bronchial (57) (60) (60) (60)
Lymph Node, Mandibular (50) (44) (47) (57)
Lymph Node, Mesenteric (59) (49) (48) (60)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mediastinal (59) (48) (48) (60)
Histiocytic Sarcoma 1 (2%)
Spleen (59) (50) (50) (60)
Hemangiosarcoma 2 (4%)
Histiocytic Sarcoma 1 (2%)
Thymus (58) (48) (48) (60)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (58) (47) (44) (53)
Adenocarcinoma 1 (2%)
Skin (59) (50) (49) (59)
Fibrosarcoma 1 (2%) 1 (2%) 1 (2%)
Myxosarcoma 1 (2%)
Subcutaneous Tissue, Osteosarcoma,
Metastatic, Bone 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (59) (50) (50) (60)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1) (2)
Fibrosarcoma, Metastatic, Skin 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (59) (50) (50) (60)
Meninges, Fibrosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2 PP
M
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (58) (60) (60) (59)
Alveolar/Bronchiolar Adenoma 4 (7%) 3 (5%) 4 (7%) 5 (8%)
Alveolar/Bronchiolar Carcinoma 3 (5%) 1 (2%) 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Hemangiosarcoma, Metastatic, Liver 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (2%) 1 (2%)
Histiocytic Sarcoma 3 (5%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Nose (59) (60) (60) (57)
Mucosa, Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (7) (6) (4) (2)
Adenocarcinoma 1 (14%)
Adenoma 4 (57%) 5 (83%) 4 (100%) 2 (100%)
Adenoma, Two 1 (17%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (50) (50) (60)
Urinary Bladder (58) (50) (50) (58)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Histiocytic Sarcoma 4 (7%) 1 (2%)
Lymphoma Malignant Histiocytic 2 (3%)
Lymphoma Malignant Lymphocytic 1 (2%) 1 (2%)
Lymphoma Malignant Mixed 12 (20%) 9 (15%) 5 (8%) 8 (13%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2 PP
M
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 35 37 34 22
Total Primary Neoplasms 56 56 46 32
Total Animals with Benign Neoplasms 24 22 25 15
Total Benign Neoplasms 28 27 33 18
Total Animals with Malignant Neoplasms 21 22 11 12
Total Malignant Neoplasms 28 28 13 14
Total Animals with Metastatic Neoplasms 1 4 1
Total Metastatic Neoplasm 1 13 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.01 PPM 0.05 PPM 0.2 PPM 0.2 PPM 0.2 PPM
SE33 SE65
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 90 60 60 60 80 50
Scheduled Sacrifice 40 10 10 10 30
Early Deaths
Moribund 8 6 3 9 7 6
Dead 6 9 5 7 7 10
Accident 1 2 1 1
Survivors
Terminal Sacrifice 35 33 42 34 35 33
Animals Examined Microscopically 90 60 60 60 80 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (80) (17) (8) (59) (20)
Intestine Small, Jejunum (80) (18) (9) (60) (20)
Adenocarcinoma 1 (1%) 1 (2%)
Intestine Small, Ileum (79) (19) (9) (60) (20)
Liver (80) (42) (47) (60) (21)
Hemangiosarcoma 1 (2%) 2 (3%)
Hepatocellular Carcinoma 9 (11%) 7 (17%) 10 (21%) 9 (15%) 1 (5%)
Hepatocellular Carcinoma, Multiple 1 (2%)
Hepatocellular Carcinoma, Two 1 (2%)
Hepatocellular Adenoma 23 (29%) 15 (36%) 21 (45%) 11 (18%)
Hepatocellular Adenoma, Multiple 1 (2%)
Hepatocellular Adenoma, Two 2 (4%) 1 (2%)
Mesentery (4) (5) (2) (2)
Pancreas (79) (18) (8) (60) (20)
Stomach, Forestomach (80) (29) (22) (60) (20)
Squamous Cell Papilloma 1 (3%) 1 (5%) 1 (2%)
Stomach, Glandular (79) (26) (18) (60) (20)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (80) (17) (8) (60) (20)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (79) (17) (8) (60) (20)
Adrenal Medulla (79) (17) (8) (60) (20)
Pheochromocytoma NOS 1 (2%)
Islets, Pancreatic (79) (17) (8) (60) (20)
Page 7
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.01 PPM 0.05 PPM 0.2 PPM 0.2 PPM 0.2 PPM
SE33 SE65
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Adenoma 1 (1%)
Pituitary Gland (77) (16) (8) (59) (20)
Carcinoma 1 (1%)
Thyroid Gland (87) (19) (12) (60) (67) (45)
Follicular Cell, Adenoma 1 (1%) 3 (25%) 2 (3%) 2 (3%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (79) (17) (8) (60) (20)
Fibrosarcoma 1 (13%)
Testes (80) (18) (9) (60) (20)
Interstitial Cell, Adenoma 1 (6%) 1 (11%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (80) (17) (8) (60) (59) (35)
Mast Cell Tumor NOS 1 (2%)
Lymph Node (1) (5) (3) (2)
Lymph Node, Bronchial (84) (27) (16) (56) (78) (48)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Lymph Node, Mandibular (60) (13) (3) (52) (15)
Lymph Node, Mesenteric (78) (22) (13) (59) (20)
Lymph Node, Mediastinal (81) (16) (8) (60) (64) (44)
Spleen (80) (18) (13) (60) (20)
Thymus (84) (16) (7) (60) (68) (46)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (80) (18) (11) (60) (68) (46)
Fibrosarcoma 1 (9%)
Hemangiosarcoma 1 (9%)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.01 PPM 0.05 PPM 0.2 PPM 0.2 PPM 0.2 PPM
SE33 SE65
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (90) (27) (18) (60) (80) (49)
Lung (89) (60) (60) (60) (78) (49)
Alveolar/Bronchiolar Adenoma 13 (15%) 7 (12%) 9 (15%) 12 (20%) 10 (13%) 14 (29%)
Alveolar/Bronchiolar Adenoma, Multiple 3 (5%) 2 (3%) 4 (7%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 3 (5%) 4 (7%) 2 (3%) 4 (5%) 1 (2%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Hemangiosarcoma, Metastatic, Liver 1 (2%)
Hepatocellular Carcinoma, Metastatic, Liver 3 (3%) 1 (2%) 3 (5%) 2 (3%)
Nose (90) (60) (60) (60) (80) (49)
Trachea (90) (60) (60) (60) (80) (49)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (7) (4) (7) (2) (4) (3)
Adenoma 7 (100%) 3 (75%) 5 (71%) 2 (100%) 4 (100%) 3 (100%)
Adenoma, Two 2 (29%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (81) (22) (12) (60) (20)
Urinary Bladder (80) (18) (17) (60) (20)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(90) *(60) *(60) *(60) *(80) *(50)
Lymphoma Malignant Histiocytic 1 (2%) 2 (3%) 1 (1%) 1 (2%)
Lymphoma Malignant Lymphocytic 1 (2%)
Lymphoma Malignant Mixed 2 (2%) 5 (8%) 4 (7%) 2 (3%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.01 PPM 0.05 PPM 0.2 PPM 0.2 PPM 0.2 PPM
SE33 SE65
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 44 35 43 36 21 24
Total Primary Neoplasms 58 47 68 57 23 26
Total Animals with Benign Neoplasms 36 25 34 27 15 18
Total Benign Neoplasms 45 31 46 35 16 20
Total Animals with Malignant Neoplasms 13 15 20 18 6 6
Total Malignant Neoplasms 13 16 22 21 6 6
Total Animals with Metastatic Neoplasms 3 2 3 2 1
Total Metastatic Neoplasm 3 2 3 2 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 10
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.5 PPM 0.5 PPM
SE26 SE42
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 90 70
Scheduled Sacrifice 40 20
Early Deaths
Dead 4 7
Moribund 5 10
Survivors
Terminal Sacrifice 41 33
Animals Examined Microscopically 90 70
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (20) (10)
Hepatocellular Adenoma 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Thyroid Gland (79) (50)
Follicular Cell, Adenoma 1 (1%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Bronchial (87) (66)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
Lymph Node, Mediastinal (75) (53)
Page 11
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.5 PPM 0.5 PPM
SE26 SE42
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (89) (70)
Alveolar/Bronchiolar Adenoma 11 (12%) 10 (14%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (1%)
Alveolar/Bronchiolar Carcinoma 5 (6%) 7 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (4) (3)
Adenoma 4 (100%) 1 (33%)
Carcinoma 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(90) *(70)
Lymphoma Malignant Histiocytic 1 (1%)
Lymphoma Malignant Mixed 1 (1%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 12
NTP Experiment-Test: 05114-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 06:55:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.5 PPM 0.5 PPM
SE26 SE42
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 20 17
Total Primary Neoplasms 24 20
Total Animals with Benign Neoplasms 15 12
Total Benign Neoplasms 17 12
Total Animals with Malignant Neoplasms 6 8
Total Malignant Neoplasms 7 8
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 13
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