https://ntp.niehs.nih.gov/go/3364

TDMS Study 05114-02 Pathology Tables

                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)
NTP Experiment-Test: 05114-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/15/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56
       Facility:  Battelle Northwest
       Chemical CAS #:  77-47-4
       Lock Date:  02/06/92
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                             Page   1
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.01 PPM     0.05 PPM     0.2   PP                                  
                                                                                          M                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Dead                                              10            8            8           13                                     
    Moribund                                           8           10           11           15                                     
    Accident                                           1                         1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           32           30           21                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Colon                             (59)         (49)         (50)         (59)                                   
   Intestine Large, Cecum                             (59)         (50)         (50)         (59)                                   
   Intestine Small, Duodenum                          (59)         (50)         (50)         (59)                                   
   Intestine Small, Jejunum                           (59)         (50)         (50)         (59)                                   
      Adenocarcinoma                                                                          1 (2%)                                
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
   Intestine Small, Ileum                             (59)         (50)         (50)         (59)                                   
   Liver                                              (59)         (60)         (60)         (60)                                   
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocellular Carcinoma                         4 (7%)       2 (3%)       4 (7%)       1 (2%)                                
      Hepatocellular Adenoma                           6 (10%)     10 (17%)      6 (10%)      6 (10%)                               
      Hepatocellular Adenoma, Two                                                1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
   Mesentery                                          (7)          (4)          (6)          (3)                                    
      Fibrosarcoma, Metastatic, Skin                                1 (25%)                                                         
      Hemangiosarcoma                                               1 (25%)                                                         
      Histiocytic Sarcoma                              1 (14%)                                                                      
   Pancreas                                           (59)         (50)         (50)         (60)                                   
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
   Salivary Glands                                    (59)         (50)         (50)         (60)                                   
   Stomach, Forestomach                               (59)         (60)         (60)         (60)                                   
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Squamous Cell Papilloma                                                    1 (2%)       2 (3%)                                
   Stomach, Glandular                                 (59)         (60)         (60)         (60)                                   
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                             Page   2                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.01 PPM     0.05 PPM     0.2   PP                                  
                                                                                          M                                         
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (59)         (50)         (50)         (60)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (59)         (50)         (50)         (60)                                   
      Carcinoma                                        1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
   Adrenal Medulla                                    (58)         (50)         (50)         (59)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
   Islets, Pancreatic                                 (59)         (50)         (49)         (60)                                   
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (59)         (49)         (48)         (60)                                   
      Adenoma                                          8 (14%)      3 (6%)       5 (10%)      3 (5%)                                
      Carcinoma                                                     1 (2%)       1 (2%)                                             
   Thyroid Gland                                      (59)         (50)         (50)         (60)                                   
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)       6 (12%)                                            
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   Tissue NOS                                                      (1)                                                              
      Sarcoma, Metastatic, Skin                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Ovary                                              (59)         (52)         (52)         (60)                                   
      Adenoma                                          1 (2%)                    2 (4%)                                             
      Cystadenoma                                                   1 (2%)                                                          
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Hemangioma                                                    1 (2%)                                                          
      Histiocytic Sarcoma                              2 (3%)                                                                       
      Teratoma NOS                                                  1 (2%)                                                          
   Uterus                                             (59)         (50)         (51)         (60)                                   
      Adenocarcinoma                                                1 (2%)                                                          
      Adenoma                                          1 (2%)                    2 (4%)                                             
      Hemangioma                                       1 (2%)       1 (2%)                                                          
      Hemangioma, Mild                                                           1 (2%)                                             
      Histiocytic Sarcoma                              3 (5%)       1 (2%)                                                          
      Endometrium, Polyp, Moderate                                  1 (2%)                                                          
      Endometrium, Polyp Stromal, Moderate                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.01 PPM     0.05 PPM     0.2   PP                                  
                                                                                          M                                         
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (59)         (50)         (50)         (60)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
   Lymph Node                                         (7)          (8)          (5)          (5)                                    
   Lymph Node, Bronchial                              (57)         (60)         (60)         (60)                                   
   Lymph Node, Mandibular                             (50)         (44)         (47)         (57)                                   
   Lymph Node, Mesenteric                             (59)         (49)         (48)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node, Mediastinal                            (59)         (48)         (48)         (60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Spleen                                             (59)         (50)         (50)         (60)                                   
      Hemangiosarcoma                                               2 (4%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Thymus                                             (58)         (48)         (48)         (60)                                   
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Mammary Gland                                      (58)         (47)         (44)         (53)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
   Skin                                               (59)         (50)         (49)         (59)                                   
      Fibrosarcoma                                     1 (2%)       1 (2%)                    1 (2%)                                
      Myxosarcoma                                                   1 (2%)                                                          
      Subcutaneous Tissue, Osteosarcoma,                                                                                            
          Metastatic, Bone                                                       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Bone                                               (59)         (50)         (50)         (60)                                   
      Osteosarcoma                                                               1 (2%)                                             
   Skeletal Muscle                                                 (1)          (1)          (2)                                    
      Fibrosarcoma, Metastatic, Skin                                1 (100%)                                                        
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   Brain                                              (59)         (50)         (50)         (60)                                   
      Meninges, Fibrosarcoma                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.01 PPM     0.05 PPM     0.2   PP                                  
                                                                                          M                                         
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (58)         (60)         (60)         (59)                                   
      Alveolar/Bronchiolar Adenoma                     4 (7%)       3 (5%)       4 (7%)       5 (8%)                                
      Alveolar/Bronchiolar Carcinoma                   3 (5%)       1 (2%)       1 (2%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                                   1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Liver                            1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       1 (2%)                                                          
      Histiocytic Sarcoma                              3 (5%)                                                                       
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
   Nose                                               (59)         (60)         (60)         (57)                                   
      Mucosa, Squamous Cell Carcinoma                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Harderian Gland                                    (7)          (6)          (4)          (2)                                    
      Adenocarcinoma                                   1 (14%)                                                                      
      Adenoma                                          4 (57%)      5 (83%)      4 (100%)     2 (100%)                              
      Adenoma, Two                                                  1 (17%)                                                         
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (59)         (50)         (50)         (60)                                   
   Urinary Bladder                                    (58)         (50)         (50)         (58)                                   
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              4 (7%)       1 (2%)                                                          
      Lymphoma Malignant Histiocytic                                2 (3%)                                                          
      Lymphoma Malignant Lymphocytic                   1 (2%)                                 1 (2%)                                
      Lymphoma Malignant Mixed                        12 (20%)      9 (15%)      5 (8%)       8 (13%)                               
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      0.01 PPM     0.05 PPM     0.2   PP                                  
                                                                                          M                                         
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)            35          37          34          22                                       
     Total Primary Neoplasms                           56          56          46          32                                       
   Total Animals with Benign Neoplasms                 24          22          25          15                                       
     Total Benign Neoplasms                            28          27          33          18                                       
   Total Animals with Malignant Neoplasms              21          22          11          12                                       
     Total Malignant Neoplasms                         28          28          13          14                                       
   Total Animals with Metastatic Neoplasms              1           4           1                                                   
     Total Metastatic Neoplasm                          1          13           2                                                   
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.01 PPM     0.05 PPM     0.2  PPM     0.2  PPM     0.2  PPM        
                                                                                                       SE33         SE65            
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          90           60           60           60           80           50           
  Scheduled Sacrifice                                 40           10           10           10           30                        
  Early Deaths                                                                                                                      
    Moribund                                           8            6            3            9            7            6           
    Dead                                               6            9            5            7            7           10           
    Accident                                           1            2                                      1            1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           33           42           34           35           33           
  Animals Examined Microscopically                    90           60           60           60           80           50           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Small, Duodenum                          (80)         (17)         (8)          (59)         (20)                      
   Intestine Small, Jejunum                           (80)         (18)         (9)          (60)         (20)                      
      Adenocarcinoma                                   1 (1%)                                 1 (2%)                                
   Intestine Small, Ileum                             (79)         (19)         (9)          (60)         (20)                      
   Liver                                              (80)         (42)         (47)         (60)         (21)                      
      Hemangiosarcoma                                               1 (2%)                    2 (3%)                                
      Hepatocellular Carcinoma                         9 (11%)      7 (17%)     10 (21%)      9 (15%)      1 (5%)                   
      Hepatocellular Carcinoma, Multiple                                                      1 (2%)                                
      Hepatocellular Carcinoma, Two                                                           1 (2%)                                
      Hepatocellular Adenoma                          23 (29%)     15 (36%)     21 (45%)     11 (18%)                               
      Hepatocellular Adenoma, Multiple                              1 (2%)                                                          
      Hepatocellular Adenoma, Two                                                2 (4%)       1 (2%)                                
   Mesentery                                          (4)          (5)          (2)          (2)                                    
   Pancreas                                           (79)         (18)         (8)          (60)         (20)                      
   Stomach, Forestomach                               (80)         (29)         (22)         (60)         (20)                      
      Squamous Cell Papilloma                                       1 (3%)       1 (5%)       1 (2%)                                
   Stomach, Glandular                                 (79)         (26)         (18)         (60)         (20)                      
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Heart                                              (80)         (17)         (8)          (60)         (20)                      
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (79)         (17)         (8)          (60)         (20)                      
   Adrenal Medulla                                    (79)         (17)         (8)          (60)         (20)                      
      Pheochromocytoma NOS                                                                    1 (2%)                                
   Islets, Pancreatic                                 (79)         (17)         (8)          (60)         (20)                      
                                                             Page   7                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.01 PPM     0.05 PPM     0.2  PPM     0.2  PPM     0.2  PPM        
                                                                                                       SE33         SE65            
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont                                                                                                             
      Adenoma                                          1 (1%)                                                                       
   Pituitary Gland                                    (77)         (16)         (8)          (59)         (20)                      
      Carcinoma                                        1 (1%)                                                                       
   Thyroid Gland                                      (87)         (19)         (12)         (60)         (67)         (45)         
      Follicular Cell, Adenoma                         1 (1%)                    3 (25%)      2 (3%)       2 (3%)       2 (4%)      
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Epididymis                                         (79)         (17)         (8)          (60)         (20)                      
      Fibrosarcoma                                                               1 (13%)                                            
   Testes                                             (80)         (18)         (9)          (60)         (20)                      
      Interstitial Cell, Adenoma                                    1 (6%)       1 (11%)      1 (2%)                                
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (80)         (17)         (8)          (60)         (59)         (35)         
      Mast Cell Tumor NOS                                                                                  1 (2%)                   
   Lymph Node                                         (1)          (5)          (3)          (2)                                    
   Lymph Node, Bronchial                              (84)         (27)         (16)         (56)         (78)         (48)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                                                         1 (2%)      
   Lymph Node, Mandibular                             (60)         (13)         (3)          (52)         (15)                      
   Lymph Node, Mesenteric                             (78)         (22)         (13)         (59)         (20)                      
   Lymph Node, Mediastinal                            (81)         (16)         (8)          (60)         (64)         (44)         
   Spleen                                             (80)         (18)         (13)         (60)         (20)                      
   Thymus                                             (84)         (16)         (7)          (60)         (68)         (46)         
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Skin                                               (80)         (18)         (11)         (60)         (68)         (46)         
      Fibrosarcoma                                                               1 (9%)                                             
      Hemangiosarcoma                                                            1 (9%)                                             
      Papilloma                                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                             Page   8                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.01 PPM     0.05 PPM     0.2  PPM     0.2  PPM     0.2  PPM        
                                                                                                       SE33         SE65            
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Larynx                                             (90)         (27)         (18)         (60)         (80)         (49)         
   Lung                                               (89)         (60)         (60)         (60)         (78)         (49)         
      Alveolar/Bronchiolar Adenoma                    13 (15%)      7 (12%)      9 (15%)     12 (20%)     10 (13%)     14 (29%)     
      Alveolar/Bronchiolar Adenoma, Multiple                        3 (5%)       2 (3%)       4 (7%)                    1 (2%)      
      Alveolar/Bronchiolar Carcinoma                                3 (5%)       4 (7%)       2 (3%)       4 (5%)       1 (2%)      
      Alveolar/Bronchiolar Carcinoma, Multiple                                                                          1 (2%)      
      Hemangiosarcoma, Metastatic, Liver                            1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      3 (3%)       1 (2%)                    3 (5%)       2 (3%)                   
   Nose                                               (90)         (60)         (60)         (60)         (80)         (49)         
   Trachea                                            (90)         (60)         (60)         (60)         (80)         (49)         
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Harderian Gland                                    (7)          (4)          (7)          (2)          (4)          (3)          
      Adenoma                                          7 (100%)     3 (75%)      5 (71%)      2 (100%)     4 (100%)     3 (100%)    
      Adenoma, Two                                                               2 (29%)                                            
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (81)         (22)         (12)         (60)         (20)                      
   Urinary Bladder                                    (80)         (18)         (17)         (60)         (20)                      
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(90)        *(60)        *(60)        *(60)        *(80)        *(50)         
      Lymphoma Malignant Histiocytic                                             1 (2%)       2 (3%)       1 (1%)       1 (2%)      
      Lymphoma Malignant Lymphocytic                                                          1 (2%)                                
      Lymphoma Malignant Mixed                         2 (2%)       5 (8%)       4 (7%)       2 (3%)                    3 (6%)      
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      0.01 PPM     0.05 PPM     0.2  PPM     0.2  PPM     0.2  PPM        
                                                                                                       SE33         SE65            
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)            44          35          43          36          21          24               
     Total Primary Neoplasms                           58          47          68          57          23          26               
   Total Animals with Benign Neoplasms                 36          25          34          27          15          18               
     Total Benign Neoplasms                            45          31          46          35          16          20               
   Total Animals with Malignant Neoplasms              13          15          20          18           6           6               
     Total Malignant Neoplasms                         13          16          22          21           6           6               
   Total Animals with Metastatic Neoplasms              3           2                       3           2           1               
     Total Metastatic Neoplasm                          3           2                       3           2           1               
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                      1           1                           
     Total Uncertain Neoplasms                                                              1           1                           
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.5  PPM     0.5  PPM                                                            
                                                   SE26         SE42                                                                
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          90           70                                                               
  Scheduled Sacrifice                                 40           20                                                               
  Early Deaths                                                                                                                      
    Dead                                               4            7                                                               
    Moribund                                           5           10                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           33                                                               
  Animals Examined Microscopically                    90           70                                                               
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (20)         (10)                                                             
      Hepatocellular Adenoma                                        1 (10%)                                                         
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Thyroid Gland                                      (79)         (50)                                                             
      Follicular Cell, Adenoma                         1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Lymph Node, Bronchial                              (87)         (66)                                                             
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
   Lymph Node, Mediastinal                            (75)         (53)                                                             
                                                             Page  11                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.5  PPM     0.5  PPM                                                            
                                                   SE26         SE42                                                                
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (89)         (70)                                                             
      Alveolar/Bronchiolar Adenoma                    11 (12%)     10 (14%)                                                         
      Alveolar/Bronchiolar Adenoma, Multiple           1 (1%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   5 (6%)       7 (10%)                                                         
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Harderian Gland                                    (4)          (3)                                                              
      Adenoma                                          4 (100%)     1 (33%)                                                         
      Carcinoma                                                     1 (33%)                                                         
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(90)        *(70)                                                             
      Lymphoma Malignant Histiocytic                   1 (1%)                                                                       
      Lymphoma Malignant Mixed                         1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 05114-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/15/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 06:55:56  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.5  PPM     0.5  PPM                                                            
                                                   SE26         SE42                                                                
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)            20          17                                                               
     Total Primary Neoplasms                           24          20                                                               
   Total Animals with Benign Neoplasms                 15          12                                                               
     Total Benign Neoplasms                            17          12                                                               
   Total Animals with Malignant Neoplasms               6           8                                                               
     Total Malignant Neoplasms                          7           8                                                               
   Total Animals with Metastatic Neoplasms                          1                                                               
     Total Metastatic Neoplasm                                      2                                                               
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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                             ----------              END OF REPORT             ----------                                           
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