TDMS Study 05114-02 Pathology Tables
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
Facility: Battelle Northwest
Chemical CAS #: 77-47-4
Lock Date: 02/06/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 6| 7| 4| 1| 7| 7| 7| 5| 7| 4| 6| 4| 5| 4| 7| 4| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 5| 5| 3| 3| 3| 2| 3| 5| 5| 5| 8| 5| 3| 5| 3| 3| 5|
| 7| 7| 4| 7| 2| 7| 3| 7| 8| 7| 7| 7| 7| 0| 7| 8| 7| 8| 9| 8| 7| 8| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cytoplasmic Alteration | |
Infiltration Cellular, Lymphocyte | 2 2 |
Inflammation, Subacute | 3 4 2 |
Inflammation, Suppurative | |
Necrosis, Acute | |
Pigmentation | 3 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Suppurative | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Mineralization | 2 |
Necrosis | |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + M + M + + M M M + M + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Hypertrophy | 2 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 6| 7| 4| 1| 7| 7| 7| 5| 7| 4| 6| 4| 5| 4| 7| 4| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 5| 5| 3| 3| 3| 2| 3| 5| 5| 5| 8| 5| 3| 5| 3| 3| 5|
| 7| 7| 4| 7| 2| 7| 3| 7| 8| 7| 7| 7| 7| 0| 7| 8| 7| 8| 9| 8| 7| 8| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Subacute | 2 |
Follicular Cell, Hyperplasia | 1 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 3 4 |
Inflammation, Subacute | 2 |
Mineralization | 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | |
Endometrium, Hyperplasia | 3 2 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + M + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 |
Hemorrhage | 4 |
Hyperplasia, Lymphoid | 2 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 6| 7| 4| 1| 7| 7| 7| 5| 7| 4| 6| 4| 5| 4| 7| 4| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 5| 5| 3| 3| 3| 2| 3| 5| 5| 5| 8| 5| 3| 5| 3| 3| 5|
| 7| 7| 4| 7| 2| 7| 3| 7| 8| 7| 7| 7| 7| 0| 7| 8| 7| 8| 9| 8| 7| 8| 7| 7| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Harderian Gland | + |
Cyst | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Casts | 3 3 |
Cyst | 1 |
Infiltration Cellular, Lymphocyte | 3 |
Inflammation, Subacute | 2 |
Nephropathy, Chronic | |
Pelvis, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 6| 3| 6| 7| 6| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 4| 3| 3| 8| 3| 9| 9| 6| 3| 9| 3| 3| 3| 5| 3| 5| 3| 1| 3| 3|
| 7| 8| 7| 7| 7| 9| 7| 7| 7| 7| 3| 6| 0| 7| 1| 7| 7| 7| 8| 7| 8| 7| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + M + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cytoplasmic Alteration | 2 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Subacute | 1 3 |
Inflammation, Suppurative | 4 |
Necrosis, Acute | 3 |
Pigmentation | |
Centrilobular, Necrosis | 4 |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Suppurative | 3 |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Mineralization | |
Necrosis | 3 2 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M M + M + M + + M + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hypertrophy | 3 3 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 6| 3| 6| 7| 6| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 4| 3| 3| 8| 3| 9| 9| 6| 3| 9| 3| 3| 3| 5| 3| 5| 3| 1| 3| 3|
| 7| 8| 7| 7| 7| 9| 7| 7| 7| 7| 3| 6| 0| 7| 1| 7| 7| 7| 8| 7| 8| 7| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Inflammation, Subacute | |
Follicular Cell, Hyperplasia | 2 1 1 3 1 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
Inflammation, Subacute | |
Mineralization | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Suppurative | 4 |
Endometrium, Hyperplasia | 3 3 3 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 3 4|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + M M M + + M + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 3 3 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 3 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 2| 7| 7| 6| 7| 6| 3| 6| 7| 6| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 4| 3| 3| 8| 3| 9| 9| 6| 3| 9| 3| 3| 3| 5| 3| 5| 3| 1| 3| 3|
| 7| 8| 7| 7| 7| 9| 7| 7| 7| 7| 3| 6| 0| 7| 1| 7| 7| 7| 8| 7| 8| 7| 6| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2 2 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Suppurative | 1 |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Suppurative | |
__________________________________________________________________________|
Harderian Gland | + + + + +|
Cyst | 2 |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Casts | |
Cyst | |
Infiltration Cellular, Lymphocyte | 3 |
Inflammation, Subacute | |
Nephropathy, Chronic | 4 |
Pelvis, Dilatation | 3 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 4| 7| 7| 4| 7| 6| | |
DAY ON TEST | 5| 8| 2| 3| 8| 3| 3| 5| 3| 2| | |
| 8| 4| 9| 7| 3| 7| 7| 8| 7| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A |
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + M + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Angiectasis | | 2 2.5|
Cytoplasmic Alteration | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 2 2.0|
Inflammation, Subacute | | 5 2.6|
Inflammation, Suppurative | | 1 4.0|
Necrosis, Acute | | 1 3.0|
Pigmentation | | 1 3.0|
Centrilobular, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Inflammation, Suppurative | | 1 3.0|
Fat, Necrosis | 3 | 4 2.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Hyperkeratosis | 3 | 3 2.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Hyperplasia | 2 | 2 2.0|
Mineralization | | 1 2.0|
Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 4| 7| 7| 4| 7| 6| | |
DAY ON TEST | 5| 8| 2| 3| 8| 3| 3| 5| 3| 2| | |
| 8| 4| 9| 7| 3| 7| 7| 8| 7| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A |
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Congestion | | 1 4.0|
Hypertrophy | | 4 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Cyst | | 1 3.0|
Inflammation, Subacute | | 1 2.0|
Follicular Cell, Hyperplasia | | 9 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Cyst | 3 3 | 8 2.9|
Inflammation, Subacute | | 1 2.0|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Hemorrhage | | 1 4.0|
Inflammation, Suppurative | | 1 4.0|
Endometrium, Hyperplasia | | 10 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 57 |
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M M + + | 50 |
Hyperplasia, Lymphoid | 4 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | 4 | 6 3.3|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | | 3 3.7|
Hemorrhage | | 1 4.0|
Hyperplasia, Lymphoid | 3 | 6 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 4| 7| 7| 4| 7| 6| | |
DAY ON TEST | 5| 8| 2| 3| 8| 3| 3| 5| 3| 2| | |
| 8| 4| 9| 7| 3| 7| 7| 8| 7| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A |
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Alopecia | | 2 2.5|
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
Fibrous Osteodystrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Mineralization | 2 | 12 2.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 58 |
Congestion | | 2 2.5|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Suppurative | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Inflammation, Suppurative | | 4 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 7 |
Cyst | | 1 2.0|
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Amyloid Deposition | | 1 4.0|
Casts | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 4| 5| 6| 7| 4| 7| 7| 4| 7| 6| | |
DAY ON TEST | 5| 8| 2| 3| 8| 3| 3| 5| 3| 2| | |
| 8| 4| 9| 7| 3| 7| 7| 8| 7| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | A |
CONTROL | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Cyst | | 1 1.0|
Infiltration Cellular, Lymphocyte | | 2 3.0|
Inflammation, Subacute | | 1 2.0|
Nephropathy, Chronic | | 1 4.0|
Pelvis, Dilatation | | 2 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 4| 6| 4| 4| 7| 4| 5| 7| 6| 5| 5| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3| 5| 6| 5| 5| 3| 5| 0| 3| 6| 7| 7| 3| 3| 3|
| 8| 7| 7| 8| 0| 7| 7| 7| 7| 7| 7| 8| 0| 8| 8| 7| 8| 3| 7| 8| 2| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.01 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 3 |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Nodular | 2 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | 4 |
Inflammation, Necrotizing | |
Inflammation, Subacute | 2 |
Mineralization | 4 |
Necrosis, Acute | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 |
Hyperplasia, Squamous | 1 |
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + M M M + M M M + M + M + M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 2 4 1 4 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 4| 6| 4| 4| 7| 4| 5| 7| 6| 5| 5| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3| 5| 6| 5| 5| 3| 5| 0| 3| 6| 7| 7| 3| 3| 3|
| 8| 7| 7| 8| 0| 7| 7| 7| 7| 7| 7| 8| 0| 8| 8| 7| 8| 3| 7| 8| 2| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.01 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | 2 4 2 2 2 4 3 3 3|
Hemorrhage | 3 |
Inflammation, Suppurative | 4 |
Granulosa Cell, Hyperplasia | 3|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Endometrium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | 3 |
__________________________________________________________________________|
Lymph Node | + + + + |
Renal, Congestion | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M M + + + + + + + M M + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | |
Thrombosis | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Suppurative | |
Pigmentation | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + M + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Alopecia | 1 |
Hemorrhage, Acute | 3 |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 4| 7| 7| 4| 3| 7| 7| 7| 7| 7| 7| 4| 6| 4| 4| 7| 4| 5| 7| 6| 5| 5| 7| 7| 7|
DAY ON TEST | 5| 3| 3| 5| 4| 3| 3| 3| 3| 3| 3| 5| 6| 5| 5| 3| 5| 0| 3| 6| 7| 7| 3| 3| 3|
| 8| 7| 7| 8| 0| 7| 7| 7| 7| 7| 7| 8| 0| 8| 8| 7| 8| 3| 7| 8| 2| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.01 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Mineralization | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 2|
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hyperplasia, Macrophage | 4 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Subacute | 3 |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Mucosa, Pigmentation | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Pigmentation | 1 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
__________________________________________________________________________|
Harderian Gland | + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + +|
Casts | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Subacute | |
Metaplasia, Osseous | |
Nephropathy, Chronic | 3 |
Renal Tubule, Degeneration, Hyaline | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 5| 5| 6| 4| 7| 5| 6| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 7| 9| 8| 5| 3| 5| 7| 3| 6| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 4| 3| 3| 3|
| 6| 3| 0| 8| 7| 8| 3| 7| 0| 7| 7| 0| 8| 3| 7| 7| 7| 7| 7| 8| 7| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 2 |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 3 2 |
Hyperplasia, Nodular | 3 |
Infiltration Cellular, Lymphocyte | 3 2|
Inflammation, Chronic | |
Inflammation, Necrotizing | 2 |
Inflammation, Subacute | 2 |
Mineralization | |
Necrosis, Acute | 2 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | |
Serosa, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + + M + + M M + M M M + M + M + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 2 3 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 5| 5| 6| 4| 7| 5| 6| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 7| 9| 8| 5| 3| 5| 7| 3| 6| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 4| 3| 3| 3|
| 6| 3| 0| 8| 7| 8| 3| 7| 0| 7| 7| 0| 8| 3| 7| 7| 7| 7| 7| 8| 7| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 3 3 2 2 2 2|
Hemorrhage | |
Inflammation, Suppurative | 4 4 |
Granulosa Cell, Hyperplasia | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2|
Endometrium, Hyperplasia | 4 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Neutrophil | |
__________________________________________________________________________|
Lymph Node | + + + |
Renal, Congestion | |
Renal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + M + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 3 4 |
Thrombosis | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | 3 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | 3 |
Hematopoietic Cell Proliferation | 4 3 3 4 3 |
Hyperplasia, Lymphoid | 3 3 4 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Hemorrhage, Acute | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 5| 5| 6| 4| 7| 5| 6| 7| 6| 7| 7| 7| 4| 6| 7| 7| 7| 7| 7| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 7| 9| 8| 5| 3| 5| 7| 3| 6| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 4| 3| 3| 3|
| 6| 3| 0| 8| 7| 8| 3| 7| 0| 7| 7| 0| 8| 3| 7| 7| 7| 7| 7| 8| 7| 6| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Mineralization | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2|
__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Macrophage | |
Infiltration Cellular, Lymphocyte | 4 3 3 |
Inflammation, Subacute | |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Mucosa, Pigmentation | 1 1 1 1 1 2 1 1 2 1 1 1 1 2 1 1 2 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Pigmentation | 2 1 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 3 |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Casts | 3 2 |
Infiltration Cellular, Lymphocyte | 3 |
Inflammation, Subacute | 2 |
Metaplasia, Osseous | 2 |
Nephropathy, Chronic | |
Renal Tubule, Degeneration, Hyaline | 4 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 7| 6| 4| 7| | |
DAY ON TEST | 3| 5| 3| 3| 3| 2| 3| 8| 5| 3| | |
| 7| 5| 7| 7| 7| 9| 7| 8| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.01 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 50 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Cytoplasmic Alteration | | 2 2.5|
Focal Cellular Change | 2 | 1 2.0|
Hematopoietic Cell Proliferation | | 3 2.3|
Hyperplasia, Nodular | | 2 2.5|
Infiltration Cellular, Lymphocyte | | 3 2.3|
Inflammation, Chronic | | 1 4.0|
Inflammation, Necrotizing | | 1 2.0|
Inflammation, Subacute | | 2 2.0|
Mineralization | | 1 4.0|
Necrosis, Acute | | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | | 1 3.0|
Hyperplasia, Squamous | | 1 1.0|
Serosa, Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M + M + + M + | 22 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 7| 6| 4| 7| | |
DAY ON TEST | 3| 5| 3| 3| 3| 2| 3| 8| 5| 3| | |
| 7| 5| 7| 7| 7| 9| 7| 8| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.01 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 49 |
Hyperplasia | 2 | 5 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 50 |
Follicular Cell, Hyperplasia | 2 3 | 14 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 52 |
Angiectasis | | 1 3.0|
Cyst | 2 2 3 | 18 2.6|
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | | 3 4.0|
Granulosa Cell, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 50 |
Hemorrhage | | 1 2.0|
Endometrium, Hyperplasia | 2 4 | 7 3.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 50 |
Hyperplasia, Neutrophil | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + | 8 |
Renal, Congestion | 4 | 1 4.0|
Renal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 2 3.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + | 44 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M + + + + + + + | 49 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | 3 | 3 3.3|
Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + + + + + | 48 |
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Pigmentation | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 7| 6| 4| 7| | |
DAY ON TEST | 3| 5| 3| 3| 3| 2| 3| 8| 5| 3| | |
| 7| 5| 7| 7| 7| 9| 7| 8| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.01 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Developmental Malformation | | 1 3.0|
Hematopoietic Cell Proliferation | | 6 3.5|
Hyperplasia, Lymphoid | | 4 3.3|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + | 47 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 50 |
Alopecia | | 1 1.0|
Hemorrhage, Acute | | 1 3.0|
Subcutaneous Tissue, Mineralization | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 50 |
Mineralization | 2 2 2 | 8 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Hyperplasia, Macrophage | | 1 4.0|
Infiltration Cellular, Lymphocyte | 3 | 4 3.3|
Inflammation, Subacute | | 1 3.0|
Alveolar Epithelium, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 1 1.0|
Mucosa, Pigmentation | 1 1 1 1 1 1 1 1 1 | 44 1.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Mucosa, Pigmentation | 1 | 6 1.2|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 7| 6| 4| 7| | |
DAY ON TEST | 3| 5| 3| 3| 3| 2| 3| 8| 5| 3| | |
| 7| 5| 7| 7| 7| 9| 7| 8| 8| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.01 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 50 |
Casts | | 2 2.5|
Infiltration Cellular, Lymphocyte | | 1 3.0|
Inflammation, Subacute | | 1 2.0|
Metaplasia, Osseous | | 1 2.0|
Nephropathy, Chronic | | 1 3.0|
Renal Tubule, Degeneration, Hyaline | | 2 3.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 50 |
Infiltration Cellular, Lymphocyte | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 4| 4| 4| 4| 5| 7| 6| 7| 7| 7| 6| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 0| 7| 3| 3| 2| 8| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 4| 3| 3| 5|
| 6| 6| 6| 6| 6| 4| 6| 6| 5| 8| 6| 8| 8| 8| 8| 4| 6| 5| 6| 6| 6| 3| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.05 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + |
Arteriole, Inflammation, Subacute | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + |
Inflammation, Suppurative | 4 |
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + |
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Nodular | |
Infiltration Cellular, Lymphocyte | |
Inflammation, Subacute | |
Necrosis, Acute | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Suppurative | |
Fat, Necrosis | 3 4 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | |
Inflammation, Subacute | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Mineralization | 2 2 |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + |
Arteriole, Inflammation, Subacute | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M M + M M M + M M + M M + + + + M + + |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 4| 4| 4| 4| 5| 7| 6| 7| 7| 7| 6| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 0| 7| 3| 3| 2| 8| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 4| 3| 3| 5|
| 6| 6| 6| 6| 6| 4| 6| 6| 5| 8| 6| 8| 8| 8| 8| 4| 6| 5| 6| 6| 6| 3| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.05 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + |
Hyperplasia | 3 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + |
Follicular Cell, Hyperplasia | 1 3 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + |
Cyst | 2 4 2 2 3 |
Inflammation, Suppurative | 4 2 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + |
Angiectasis | |
Hemorrhage | |
Inflammation, Suppurative | 2 3 |
Endometrium, Hyperplasia | 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + M + + + + + + |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
Inflammation, Suppurative | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + |
Hematopoietic Cell Proliferation | 3 3 3 |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + + + M + + |
Duct, Dilatation | |
__________________________________________________________________________|
Skin | + + + M + + + + + + + + + + + + + + + + |
Alopecia | 2 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 6| 6| 7| 4| 4| 4| 4| 5| 7| 6| 7| 7| 7| 6| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 0| 7| 3| 3| 2| 8| 3| 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 4| 3| 3| 5|
| 6| 6| 6| 6| 6| 4| 6| 6| 5| 8| 6| 8| 8| 8| 8| 4| 6| 5| 6| 6| 6| 3| 6| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.05 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
Developmental Malformation | |
Fracture | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + |
Compression | |
Mineralization | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Subacute | |
Alveolar Epithelium, Hyperplasia | |
Mucosa, Pigmentation | 1 1 2 2 1 1 1 1 1 2 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Inflammation, Suppurative | |
Mucosa, Pigmentation | 4 3 4 3 3 3 3 4 3 3 2 2 2 2 2 3 2 3 4 3 2 3 3 1|
__________________________________________________________________________|
Trachea | + + + + + + + + A + + + + + + + + A + + + + + + +|
Mucosa, Pigmentation | 2 2 2 2 2 1 2 2 1 2 2 2 1 1 2 2 2 2 2 2 2 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Edema | 1 |
Cornea, Hyperplasia | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | |
Casts | |
Inflammation, Chronic | |
Inflammation, Subacute | 2 3 |
Metaplasia, Osseous | 3 |
Mineralization | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 4| 7| 4| 5| 0| 7| 5| 7| 7| 7| 4| 7| 4| 5| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 3| 7| 5| 3| 5| 1| 1| 5| 7| 3| 9| 3| 3| 3| 5| 3| 5| 7| 3| 3| 5| 3| 3| 5|
| 6| 6| 4| 8| 6| 8| 5| 1| 4| 4| 6| 2| 6| 6| 6| 8| 6| 8| 5| 6| 6| 8| 6| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.05 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation, Subacute | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 3 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Nodular | 3 |
Infiltration Cellular, Lymphocyte | |
Inflammation, Subacute | 3 2 |
Necrosis, Acute | 2 |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Suppurative | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Inflammation, Subacute | |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Mineralization | |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + +|
Arteriole, Inflammation, Subacute | 3 |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + M + M M + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 4| 7| 4| 5| 0| 7| 5| 7| 7| 7| 4| 7| 4| 5| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 3| 7| 5| 3| 5| 1| 1| 5| 7| 3| 9| 3| 3| 3| 5| 3| 5| 7| 3| 3| 5| 3| 3| 5|
| 6| 6| 4| 8| 6| 8| 5| 1| 4| 4| 6| 2| 6| 6| 6| 8| 6| 8| 5| 6| 6| 8| 6| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.05 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 3 1 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 3 4 |
Inflammation, Suppurative | 4 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + M + + + + + + + + + + + + +|
Angiectasis | 3 |
Hemorrhage | 4 |
Inflammation, Suppurative | |
Endometrium, Hyperplasia | 4 2 1 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3|
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3|
Hyperplasia, Lymphoid | 4 4 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + M|
Duct, Dilatation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Inflammation, Suppurative | 4|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 6| 4| 7| 4| 7| 4| 5| 0| 7| 5| 7| 7| 7| 4| 7| 4| 5| 7| 7| 4| 7| 7| 6|
DAY ON TEST | 3| 3| 7| 5| 3| 5| 1| 1| 5| 7| 3| 9| 3| 3| 3| 5| 3| 5| 7| 3| 3| 5| 3| 3| 5|
| 6| 6| 4| 8| 6| 8| 5| 1| 4| 4| 6| 2| 6| 6| 6| 8| 6| 8| 5| 6| 6| 8| 6| 6| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.05 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fracture | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Mineralization | 2 2 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 |
Inflammation, Subacute | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Mucosa, Pigmentation | 1 1 1 1 1 1 1 1 2 2 2 1 2 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2|
Inflammation, Suppurative | 1 2 |
Mucosa, Pigmentation | 3 3 1 2 4 1 2 1 2 3 3 2 2 4 1 3 2 2 3 3 3 2 3 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Pigmentation | 2 1 1 2 2 1 1 1 2 1 2 1 1 1 2 2 2 1 1 2 2 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Edema | |
Cornea, Hyperplasia | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Casts | 3 |
Inflammation, Chronic | |
Inflammation, Subacute | |
Metaplasia, Osseous | |
Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 6| 3| 3| 1| 3| 3| 3| 7| 0| | |
| 6| 0| 6| 6| 8| 0| 6| 6| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.05 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 50 |
Arteriole, Inflammation, Subacute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 50 |
Inflammation, Suppurative | | 1 4.0|
Peyer's Patch, Hyperplasia, Lymphoid | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 50 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Focal Cellular Change | 3 | 2 3.0|
Hematopoietic Cell Proliferation | | 2 2.5|
Hyperplasia, Nodular | | 1 3.0|
Infiltration Cellular, Lymphocyte | 3 | 1 3.0|
Inflammation, Subacute | | 2 2.5|
Necrosis, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Inflammation, Suppurative | 4 | 1 4.0|
Fat, Necrosis | 3 | 5 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 50 |
Amyloid Deposition | 4 | 1 4.0|
Inflammation, Subacute | 3 | 1 3.0|
Inflammation, Suppurative | 4 | 2 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Hemorrhage | | 1 4.0|
Mineralization | | 2 2.0|
Necrosis | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 50 |
Arteriole, Inflammation, Subacute | | 1 3.0|
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 6| 3| 3| 1| 3| 3| 3| 7| 0| | |
| 6| 0| 6| 6| 8| 0| 6| 6| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.05 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + + + + | 33 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + | 48 |
Hyperplasia | 3 | 7 2.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 50 |
Follicular Cell, Hyperplasia | 2 4 1 2 | 16 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 52 |
Cyst | 2 4 2 3 | 13 2.8|
Inflammation, Suppurative | 2 | 6 3.3|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 51 |
Angiectasis | | 1 3.0|
Hemorrhage | 4 | 2 4.0|
Inflammation, Suppurative | | 2 2.5|
Endometrium, Hyperplasia | | 7 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Lymph Node | | 5 |
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 4 3.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + + + M | 47 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 48 |
Hyperplasia, Lymphoid | 3 3 3 | 5 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + M + | 48 |
Hyperplasia, Lymphoid | 4 | 2 3.5|
Hyperplasia, Plasma Cell | | 1 3.0|
Inflammation, Suppurative | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 6| 3| 3| 1| 3| 3| 3| 7| 0| | |
| 6| 0| 6| 6| 8| 0| 6| 6| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.05 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | 3 | 7 3.0|
Hyperplasia, Lymphoid | 3 | 6 3.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + | 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + M + + + | 44 |
Duct, Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 49 |
Alopecia | 2 | 2 2.0|
Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 50 |
Developmental Malformation | 3 | 1 3.0|
Fracture | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 50 |
Compression | | 1 4.0|
Mineralization | 2 | 4 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | 3 | 3 2.7|
Inflammation, Subacute | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Mucosa, Pigmentation | 2 1 1 | 31 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Subacute | | 1 2.0|
Inflammation, Suppurative | 2 | 3 1.7|
Mucosa, Pigmentation | 2 1 3 3 3 1 2 2 2 2 | 59 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 58 |
Mucosa, Pigmentation | 2 1 2 2 1 1 2 2 2 | 53 1.6|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 6| 3| 3| 1| 3| 3| 3| 7| 0| | |
| 6| 0| 6| 6| 8| 0| 6| 6| 4| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.05 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
Cornea, Edema | | 1 1.0|
Cornea, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 50 |
Amyloid Deposition | | 1 4.0|
Casts | | 1 3.0|
Inflammation, Chronic | 4 | 1 4.0|
Inflammation, Subacute | | 2 2.5|
Metaplasia, Osseous | | 1 3.0|
Mineralization | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 4| 4| 6| 6| 7| 7| 4| 6| 5| 6| 6| 6| 6| 7| 6| 4| 5| 7| 7| 4| 4| 6| 5| 5| 7|
DAY ON TEST | 0| 1| 1| 7| 3| 3| 9| 9| 4| 0| 1| 1| 2| 3| 9| 5| 1| 3| 3| 5| 9| 9| 0| 2| 3|
| 0| 8| 8| 4| 6| 6| 6| 5| 6| 6| 0| 1| 1| 6| 6| 8| 6| 6| 6| 8| 8| 0| 0| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.2 PP | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Subacute | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | X |
Congestion | |
Cytoplasmic Alteration, Focal | |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 4 2 |
Inflammation, Subacute | 2 2 2 |
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 3 2 |
Acinar Cell, Hypoplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Hyperplasia, Squamous | 3 |
Serosa, Fibrosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Mineralization | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + M + + M M M M M + M + M + M + + + M M M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 4| 4| 6| 6| 7| 7| 4| 6| 5| 6| 6| 6| 6| 7| 6| 4| 5| 7| 7| 4| 4| 6| 5| 5| 7|
DAY ON TEST | 0| 1| 1| 7| 3| 3| 9| 9| 4| 0| 1| 1| 2| 3| 9| 5| 1| 3| 3| 5| 9| 9| 0| 2| 3|
| 0| 8| 8| 4| 6| 6| 6| 5| 6| 6| 0| 1| 1| 6| 6| 8| 6| 6| 6| 8| 8| 0| 0| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.2 PP | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cyst | |
Hyperplasia | 2 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 3 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 |
Inflammation, Subacute | |
Inflammation, Suppurative | 4 4 4 4 4 4 4 3 4 4 4 |
Pigmentation | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Inflammation, Suppurative | 2 2 |
Endometrium, Hyperplasia | 2 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Renal, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 4 |
Hyperplasia, Mast Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 4 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 3 |
Inflammation, Suppurative | 4 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 3 4 4 4 3 4 3 3 2 |
Inflammation, Suppurative | |
Capsule, Inflammation, Subacute | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 4| 4| 6| 6| 7| 7| 4| 6| 5| 6| 6| 6| 6| 7| 6| 4| 5| 7| 7| 4| 4| 6| 5| 5| 7|
DAY ON TEST | 0| 1| 1| 7| 3| 3| 9| 9| 4| 0| 1| 1| 2| 3| 9| 5| 1| 3| 3| 5| 9| 9| 0| 2| 3|
| 0| 8| 8| 4| 6| 6| 6| 5| 6| 6| 0| 1| 1| 6| 6| 8| 6| 6| 6| 8| 8| 0| 0| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.2 PP | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | X |
Inflammation, Suppurative | 4 |
Mineralization | 2 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | X |
Infiltration Cellular, Lymphocyte | |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Subacute | 3 |
Inflammation, Suppurative | 4 4 |
Alveolar Epithelium, Hyperplasia | 2 2 |
Mucosa, Pigmentation | 2 2 1 2 3 2 3 2 2 1 2 2 1 2 3 3 3 2 2 1 2 1|
Pleura, Inflammation, Suppurative | 2 3 |
__________________________________________________________________________|
Nose | + A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 3 2 2 3 2 2 3 1 2 3 3 1 1 1 1 2 2 1|
Mucosa, Pigmentation | 2 2 3 3 2 2 2 2 1 1 2 2 1 2 1 1 3 2 2 1 1|
__________________________________________________________________________|
Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Mucosa, Pigmentation | 2 2 2 3 2 2 1 2 2 2 2 2 2 2 3 2 2 1 3 1 2 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | X |
Casts | |
Congestion | |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 4| 4| 6| 6| 7| 7| 4| 6| 5| 6| 6| 6| 6| 7| 6| 4| 5| 7| 7| 4| 4| 6| 5| 5| 7|
DAY ON TEST | 0| 1| 1| 7| 3| 3| 9| 9| 4| 0| 1| 1| 2| 3| 9| 5| 1| 3| 3| 5| 9| 9| 0| 2| 3|
| 0| 8| 8| 4| 6| 6| 6| 5| 6| 6| 0| 1| 1| 6| 6| 8| 6| 6| 6| 8| 8| 0| 0| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.2 PP | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Subacute | 2 2 |
Nephropathy, Chronic | 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 4| 5| 4| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 7| 3| 5| 5| 1| 5| 3| 3| 1| 5| 5| 2| 1| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3|
| 9| 6| 3| 6| 8| 8| 9| 8| 6| 0| 4| 8| 8| 4| 0| 6| 6| 6| 8| 6| 0| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
0.2 PP | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Subacute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Congestion | 2 |
Cytoplasmic Alteration, Focal | 2 2 |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 3 3 |
Inflammation, Subacute | 2 2 |
Serosa, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Acinar Cell, Hypoplasia | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 3 |
Hyperplasia, Squamous | 2 |
Serosa, Fibrosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Mineralization | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + + M + + + + + + + + M + + M + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 4| 5| 4| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 7| 3| 5| 5| 1| 5| 3| 3| 1| 5| 5| 2| 1| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3|
| 9| 6| 3| 6| 8| 8| 9| 8| 6| 0| 4| 8| 8| 4| 0| 6| 6| 6| 8| 6| 0| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
0.2 PP | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cyst | 2 |
Hyperplasia | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 3 2 1 2 2 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 2 1 4 4 2 |
Inflammation, Subacute | |
Inflammation, Suppurative | 4 4 4 4 |
Pigmentation | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | 2 |
Endometrium, Hyperplasia | 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + |
Renal, Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 3 |
Hyperplasia, Mast Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 4 3 3 |
Inflammation, Suppurative | 4 |
Capsule, Inflammation, Subacute | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 4| 5| 4| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 7| 3| 5| 5| 1| 5| 3| 3| 1| 5| 5| 2| 1| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3|
| 9| 6| 3| 6| 8| 8| 9| 8| 6| 0| 4| 8| 8| 4| 0| 6| 6| 6| 8| 6| 0| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
0.2 PP | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + M + + + M + M M + + M + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Inflammation, Suppurative | |
Mineralization | 1 2 2 2 2|
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + A + + + + + + + + + +|
Bacterium | |
Infiltration Cellular, Lymphocyte | 2 |
Infiltration Cellular, Histiocyte | |
Inflammation, Subacute | 2 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | |
Mucosa, Pigmentation | 2 2 2 2 3 2 1 2 2 3 2 2 2 2 2 2 2 2 2 2 2 3 2|
Pleura, Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Suppurative | 2 2 4 2 3 3 2 3 2 4 2 2 3 4 3 2 1 4 2 3|
Mucosa, Pigmentation | 2 2 2 1 2 1 4 2 2 1 1 1 2 2 2 1 2 2 3 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + A + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Mucosa, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Casts | 2 |
Congestion | 1 |
Infiltration Cellular, Lymphocyte | 3 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 6| 7| 6| 7| 4| 4| 5| 4| 7| 7| 6| 4| 4| 7| 6| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 1| 3| 7| 3| 5| 5| 1| 5| 3| 3| 1| 5| 5| 2| 1| 3| 3| 3| 5| 3| 7| 3| 3| 3| 3|
| 9| 6| 3| 6| 8| 8| 9| 8| 6| 0| 4| 8| 8| 4| 0| 6| 6| 6| 8| 6| 0| 6| 6| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
0.2 PP | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation, Subacute | |
Nephropathy, Chronic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 7| 0| 4| 5| | |
DAY ON TEST | 3| 5| 6| 3| 3| 3| 3| 2| 5| 5| | |
| 6| 8| 6| 6| 6| 0| 6| 2| 8| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.2 PP | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 60 |
Serosa, Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Inflammation, Suppurative | | 2 3.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Bacterium | | 1 |
Congestion | | 1 2.0|
Cytoplasmic Alteration, Focal | | 2 2.0|
Focal Cellular Change | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 2 2 | 6 2.7|
Inflammation, Subacute | 2 2 2 | 8 2.0|
Serosa, Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Fat, Necrosis | 4 | 3 3.7|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Inflammation, Suppurative | | 3 3.0|
Acinar Cell, Hypoplasia | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | 3 4 2 | 5 2.8|
Hyperplasia, Squamous | 4 | 3 3.0|
Serosa, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Necrosis | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Amyloid Deposition | | 1 3.0|
Mineralization | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 7| 0| 4| 5| | |
DAY ON TEST | 3| 5| 6| 3| 3| 3| 3| 2| 5| 5| | |
| 6| 8| 6| 6| 6| 0| 6| 2| 8| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.2 PP | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + M + + | 59 |
Amyloid Deposition | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 38 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Cyst | | 1 2.0|
Hyperplasia | 2 | 3 2.0|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Hyperplasia | 3 1 4 | 14 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | 3 3 | 10 2.7|
Inflammation, Subacute | 2 | 1 2.0|
Inflammation, Suppurative | 4 4 | 17 3.9|
Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hemorrhage | | 1 1.0|
Inflammation, Suppurative | 2 | 4 2.0|
Endometrium, Hyperplasia | 3 | 5 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + | 5 |
Renal, Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 57 |
Hyperplasia, Lymphoid | 4 4 | 7 3.4|
Hyperplasia, Mast Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 2 3.5|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 7| 0| 4| 5| | |
DAY ON TEST | 3| 5| 6| 3| 3| 3| 3| 2| 5| 5| | |
| 6| 8| 6| 6| 6| 0| 6| 2| 8| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.2 PP | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | | 4 2.8|
Inflammation, Suppurative | | 3 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | 3 3 | 17 3.4|
Inflammation, Suppurative | | 1 4.0|
Capsule, Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Developmental Malformation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Bacterium | | 1 |
Inflammation, Suppurative | | 1 4.0|
Mineralization | | 7 1.9|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Bacterium | | 1 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Subacute | | 2 2.5|
Inflammation, Suppurative | | 2 4.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
Mucosa, Pigmentation | 2 3 1 1 2 1 2 2 1 | 56 2.0|
Pleura, Inflammation, Suppurative | | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 57 |
Inflammation, Suppurative | 2 3 4 4 2 2 4 2 2 | 48 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 7| 7| 7| 0| 4| 5| | |
DAY ON TEST | 3| 5| 6| 3| 3| 3| 3| 2| 5| 5| | |
| 6| 8| 6| 6| 6| 0| 6| 2| 8| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.2 PP | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
M | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mucosa, Pigmentation | 2 1 2 1 2 2 2 | 50 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + A | 57 |
Inflammation, Suppurative | | 2 1.5|
Mucosa, Pigmentation | 2 2 2 2 2 2 2 2 | 52 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Bacterium | | 1 |
Casts | | 1 2.0|
Congestion | | 1 1.0|
Infiltration Cellular, Lymphocyte | | 1 3.0|
Inflammation, Subacute | | 2 2.0|
Nephropathy, Chronic | | 2 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + M + + M + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 2| 2| 6| 6| 1| 7| 4| 7| 4| 4| 1| 7| 4| 7| 6| 1| 7| 7| 7| 4| 7| 6| 7| 1| 7|
DAY ON TEST | 9| 9| 4| 4| 8| 3| 5| 3| 5| 5| 8| 3| 5| 3| 0| 8| 1| 3| 3| 5| 3| 2| 3| 8| 3|
| 5| 5| 8| 9| 3| 3| 9| 3| 9| 9| 3| 3| 9| 3| 7| 3| 1| 3| 3| 9| 3| 6| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 |
Cyst | |
Cytoplasmic Alteration | |
Fatty Change | |
Focal Cellular Change | 2 |
Hyperplasia, Nodular | |
Infarct | |
Inflammation, Chronic | |
Inflammation, Necrotizing | |
Inflammation, Subacute | 2 3 |
Inflammation, Suppurative | |
Necrosis, Acute | |
__________________________________________________________________________|
Mesentery | + + + |
Necrosis | 2 |
Fat, Hemorrhage | 2 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Duct, Cyst | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 2| 2| 6| 6| 1| 7| 4| 7| 4| 4| 1| 7| 4| 7| 6| 1| 7| 7| 7| 4| 7| 6| 7| 1| 7|
DAY ON TEST | 9| 9| 4| 4| 8| 3| 5| 3| 5| 5| 8| 3| 5| 3| 0| 8| 1| 3| 3| 5| 3| 2| 3| 8| 3|
| 5| 5| 8| 9| 3| 3| 9| 3| 9| 9| 3| 3| 9| 3| 7| 3| 1| 3| 3| 9| 3| 6| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M + + + + + M + M M + + M + + + + M M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Penis | + + + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Preputial Gland | + + + |
Inflammation, Granulomatous | |
Inflammation, Suppurative | 3 |
Duct, Dilatation | 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hemorrhage | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + M + + + + + M + + + + + + + + M + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M M + + + + + M + + + M + + +|
Congestion | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + +|
Congestion | |
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + M + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | M + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 2| 2| 6| 6| 1| 7| 4| 7| 4| 4| 1| 7| 4| 7| 6| 1| 7| 7| 7| 4| 7| 6| 7| 1| 7|
DAY ON TEST | 9| 9| 4| 4| 8| 3| 5| 3| 5| 5| 8| 3| 5| 3| 0| 8| 1| 3| 3| 5| 3| 2| 3| 8| 3|
| 5| 5| 8| 9| 3| 3| 9| 3| 9| 9| 3| 3| 9| 3| 7| 3| 1| 3| 3| 9| 3| 6| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M + M M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Inflammation, Suppurative | 4 3 4 |
Prepuce, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Mineralization | 2 2|
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Histiocyte | |
Inflammation, Subacute | |
Bronchiole, Hyperplasia | |
Pleura, Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + +|
Casts | |
Cyst | |
Dilatation | 2 2 2|
Hydronephrosis | |
Hypertrophy | 2 |
Inflammation, Chronic | |
Inflammation, Subacute | |
Inflammation, Suppurative | 2 3 |
Nephropathy, Chronic | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 2| 2| 6| 6| 1| 7| 4| 7| 4| 4| 1| 7| 4| 7| 6| 1| 7| 7| 7| 4| 7| 6| 7| 1| 7|
DAY ON TEST | 9| 9| 4| 4| 8| 3| 5| 3| 5| 5| 8| 3| 5| 3| 0| 8| 1| 3| 3| 5| 3| 2| 3| 8| 3|
| 5| 5| 8| 9| 3| 3| 9| 3| 9| 9| 3| 3| 9| 3| 7| 3| 1| 3| 3| 9| 3| 6| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Polycystic Kidney | 4 |
Pelvis, Dilatation | 2 2 2 |
Renal Tubule, Cytoplasmic Alteration | |
__________________________________________________________________________|
Urethra | + |
Concretion | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + +|
Concretion | |
Dilatation | 3 2 2 2 4 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 6| 4| 7| 7| 7| 1| 2| 7| 7| 1| 7| 7| 7| 6| 2| 7| 1| 7| 2| 2|
DAY ON TEST | 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 8| 9| 3| 3| 8| 3| 3| 3| 8| 9| 3| 8| 3| 6| 3|
| 2| 2| 2| 2| 5| 7| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Cyst | |
Cytoplasmic Alteration | |
Fatty Change | |
Focal Cellular Change | |
Hyperplasia, Nodular | |
Infarct | 4 |
Inflammation, Chronic | 3 |
Inflammation, Necrotizing | 4 |
Inflammation, Subacute | |
Inflammation, Suppurative | 3 |
Necrosis, Acute | |
__________________________________________________________________________|
Mesentery | |
Necrosis | |
Fat, Hemorrhage | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + M|
Mineralization | |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 6| 4| 7| 7| 7| 1| 2| 7| 7| 1| 7| 7| 7| 6| 2| 7| 1| 7| 2| 2|
DAY ON TEST | 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 8| 9| 3| 3| 8| 3| 3| 3| 8| 9| 3| 8| 3| 6| 3|
| 2| 2| 2| 2| 5| 7| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M M M M + + + + + + + + + + M + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Penis | + |
Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + |
Inflammation, Granulomatous | 2 |
Inflammation, Suppurative | 4 |
Duct, Dilatation | 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hemorrhage | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Lymph Node, Mandibular | M M + M M M + + + + M + M + + + M M + + + M|
Congestion | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 6| 4| 7| 7| 7| 1| 2| 7| 7| 1| 7| 7| 7| 6| 2| 7| 1| 7| 2| 2|
DAY ON TEST | 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 8| 9| 3| 3| 8| 3| 3| 3| 8| 9| 3| 8| 3| 6| 3|
| 2| 2| 2| 2| 5| 7| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M + + M M M M M M M + M M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 2 |
Inflammation, Suppurative | 3 |
Prepuce, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Mineralization | 2 2 2 2 2 |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Histiocyte | |
Inflammation, Subacute | 2 |
Bronchiole, Hyperplasia | |
Pleura, Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + +|
Casts | |
Cyst | |
Dilatation | |
Hydronephrosis | 4 |
Hypertrophy | |
Inflammation, Chronic | |
Inflammation, Subacute | 2 2 2 2 |
Inflammation, Suppurative | 4 |
Nephropathy, Chronic | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 6| 4| 7| 7| 7| 1| 2| 7| 7| 1| 7| 7| 7| 6| 2| 7| 1| 7| 2| 2|
DAY ON TEST | 3| 3| 3| 3| 9| 2| 5| 3| 3| 3| 8| 9| 3| 3| 8| 3| 3| 3| 8| 9| 3| 8| 3| 6| 3|
| 2| 2| 2| 2| 5| 7| 9| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 5| 3| 3| 3| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Polycystic Kidney | |
Pelvis, Dilatation | 2 2 3 |
Renal Tubule, Cytoplasmic Alteration | |
__________________________________________________________________________|
Urethra | |
Concretion | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 4 |
Dilatation | 4 4 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 1| 4| 0| 2| 7| 7| 2| 7| 7| 7| 6| 7| 7| 2| 2| 7| 6| 7| 4| 7| 4| 2| 2| 1| 2|
DAY ON TEST | 8| 5| 3| 9| 3| 3| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 8| 3| 5| 3| 6| 3| 3| 8| 3|
| 3| 9| 7| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 5| 2| 3| 9| 3| 9| 3| 4| 2| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + M + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Cyst | 3 |
Cytoplasmic Alteration | 2 |
Fatty Change | 3 |
Focal Cellular Change | |
Hyperplasia, Nodular | |
Infarct | |
Inflammation, Chronic | |
Inflammation, Necrotizing | |
Inflammation, Subacute | 4 |
Inflammation, Suppurative | |
Necrosis, Acute | 3 |
__________________________________________________________________________|
Mesentery | + |
Necrosis | |
Fat, Hemorrhage | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 1| 4| 0| 2| 7| 7| 2| 7| 7| 7| 6| 7| 7| 2| 2| 7| 6| 7| 4| 7| 4| 2| 2| 1| 2|
DAY ON TEST | 8| 5| 3| 9| 3| 3| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 8| 3| 5| 3| 6| 3| 3| 8| 3|
| 3| 9| 7| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 5| 2| 3| 9| 3| 9| 3| 4| 2| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M + M + M + M M M M + + M + + + M M M M M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + M + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Penis | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + |
Inflammation, Granulomatous | |
Inflammation, Suppurative | |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hemorrhage | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + M + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + + M + + + + M + + + + + + + + + M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 1| 4| 0| 2| 7| 7| 2| 7| 7| 7| 6| 7| 7| 2| 2| 7| 6| 7| 4| 7| 4| 2| 2| 1| 2|
DAY ON TEST | 8| 5| 3| 9| 3| 3| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 8| 3| 5| 3| 6| 3| 3| 8| 3|
| 3| 9| 7| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 5| 2| 3| 9| 3| 9| 3| 4| 2| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M M M M M M M M M M + M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Inflammation, Suppurative | |
Prepuce, Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Mineralization | 2 3 2 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Histiocyte | |
Inflammation, Subacute | |
Bronchiole, Hyperplasia | |
Pleura, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Acute | 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Casts | 3 |
Cyst | |
Dilatation | |
Hydronephrosis | |
Hypertrophy | |
Inflammation, Chronic | |
Inflammation, Subacute | |
Inflammation, Suppurative | |
Nephropathy, Chronic | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 1| 4| 0| 2| 7| 7| 2| 7| 7| 7| 6| 7| 7| 2| 2| 7| 6| 7| 4| 7| 4| 2| 2| 1| 2|
DAY ON TEST | 8| 5| 3| 9| 3| 3| 3| 3| 3| 3| 8| 3| 3| 9| 3| 3| 8| 3| 5| 3| 6| 3| 3| 8| 3|
| 3| 9| 7| 5| 3| 3| 2| 3| 3| 3| 2| 3| 3| 5| 2| 3| 9| 3| 9| 3| 4| 2| 2| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Polycystic Kidney | |
Pelvis, Dilatation | |
Renal Tubule, Cytoplasmic Alteration | |
__________________________________________________________________________|
Urethra | |
Concretion | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | |
Dilatation | 2 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 4| 1| 2| 7| 7| 7| 7| 4| 2| 2| | |
DAY ON TEST | 1| 3| 3| 4| 5| 5| 8| 9| 3| 3| 3| 3| 5| 9| 9| | |
| 7| 3| 3| 3| 4| 9| 3| 5| 3| 3| 3| 3| 9| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + | 89 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + + + + + + + + + | 75 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + | 80 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + | 80 |
Peyer's Patch, Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + | 79 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + | 80 |
Basophilic Focus | | 1 3.0|
Cyst | | 1 3.0|
Cytoplasmic Alteration | | 1 2.0|
Fatty Change | | 1 3.0|
Focal Cellular Change | | 1 2.0|
Hyperplasia, Nodular | 3 | 1 3.0|
Infarct | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Necrotizing | | 1 4.0|
Inflammation, Subacute | 4 | 4 3.3|
Inflammation, Suppurative | | 1 3.0|
Necrosis, Acute | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Necrosis | | 1 2.0|
Fat, Hemorrhage | | 1 2.0|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + M + + + + + + + + + | 79 |
Inflammation, Subacute | 2 | 1 2.0|
Duct, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + | 79 |
Mineralization | | 1 2.0|
Necrosis | | 3 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 4| 1| 2| 7| 7| 7| 7| 4| 2| 2| | |
DAY ON TEST | 1| 3| 3| 4| 5| 5| 8| 9| 3| 3| 3| 3| 5| 9| 9| | |
| 7| 3| 3| 3| 4| 9| 3| 5| 3| 3| 3| 3| 9| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Atrium, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + M + + + + + + + + + | 79 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + M + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + M + + + M M + M + + | 53 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + + + + + | 77 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + M + + + + + + + + + | 87 |
Follicular Cell, Hyperplasia | | 4 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + | 79 |
Inflammation, Granulomatous | 3 | 1 3.0|
__________________________________________________________________________|____________|
Penis | | 4 |
Inflammation, Suppurative | | 2 3.5|
__________________________________________________________________________|____________|
Preputial Gland | + | 9 |
Inflammation, Granulomatous | | 1 2.0|
Inflammation, Suppurative | | 2 3.5|
Duct, Dilatation | 4 | 5 3.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + | 80 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + | 80 |
Dilatation | | 1 3.0|
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + | 80 |
Atrophy | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + | 80 |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + | 84 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M M + M + + + + + + M + | 60 |
Congestion | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 4| 1| 2| 7| 7| 7| 7| 4| 2| 2| | |
DAY ON TEST | 1| 3| 3| 4| 5| 5| 8| 9| 3| 3| 3| 3| 5| 9| 9| | |
| 7| 3| 3| 3| 4| 9| 3| 5| 3| 3| 3| 3| 9| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + | 78 |
Congestion | 2 | 1 2.0|
Hemorrhage | 3 | 2 2.5|
Hyperplasia, Lymphoid | | 4 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + + + + + + + + + + + | 81 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + | 80 |
Hematopoietic Cell Proliferation | 3 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + + | 84 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M | 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + | 80 |
Alopecia | | 2 2.0|
Inflammation, Suppurative | | 4 3.5|
Prepuce, Inflammation, Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + | 80 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + | 80 |
Compression | | 1 2.0|
Mineralization | 3 2 2 2 2 1 | 17 2.1|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + | 90 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + | 89 |
Congestion | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Inflammation, Subacute | | 1 2.0|
Bronchiole, Hyperplasia | 2 | 1 2.0|
Pleura, Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 90 |
Hemorrhage, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 90 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 4| 1| 2| 7| 7| 7| 7| 4| 2| 2| | |
DAY ON TEST | 1| 3| 3| 4| 5| 5| 8| 9| 3| 3| 3| 3| 5| 9| 9| | |
| 7| 3| 3| 3| 4| 9| 3| 5| 3| 3| 3| 3| 9| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 7 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 81 |
Casts | | 1 3.0|
Cyst | 2 | 1 2.0|
Dilatation | | 3 2.0|
Hydronephrosis | | 1 4.0|
Hypertrophy | | 1 2.0|
Inflammation, Chronic | 4 | 1 4.0|
Inflammation, Subacute | 2 | 5 2.0|
Inflammation, Suppurative | | 3 3.0|
Nephropathy, Chronic | 2 2 | 2 2.0|
Polycystic Kidney | | 1 4.0|
Pelvis, Dilatation | | 6 2.2|
Renal Tubule, Cytoplasmic Alteration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Concretion | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + | 80 |
Concretion | | 1 4.0|
Dilatation | | 8 2.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 1| 5| 3| 3| 3| 3| 5| 3| 5| 3| 3| 3| 5| 4| 2| 3| 3| 5| 3| 3|
| 3| 9| 3| 3| 3| 6| 9| 3| 3| 3| 3| 7| 3| 9| 3| 3| 3| 9| 3| 5| 3| 3| 9| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.01 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Cyst | 3 |
Fibrosis | 3 |
Focal Cellular Change | |
Infarct | |
Inflammation, Chronic | 3 |
Inflammation, Subacute | |
Necrosis, Acute | |
__________________________________________________________________________|
Mesentery | |
Congestion | |
Inflammation, Suppurative | |
Necrosis | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + |
Duct, Cyst | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + |
Hyperkeratosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + |
Necrosis | |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | 2 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + |
Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + |
__________________________________________________________________________|
Adrenal Medulla | + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + M + + |
__________________________________________________________________________|
Pituitary Gland | + + M + + |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 1| 5| 3| 3| 3| 3| 5| 3| 5| 3| 3| 3| 5| 4| 2| 3| 3| 5| 3| 3|
| 3| 9| 3| 3| 3| 6| 9| 3| 3| 3| 3| 7| 3| 9| 3| 3| 3| 9| 3| 5| 3| 3| 9| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.01 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + |
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Penis | |
Concretion | |
Hemorrhage, Acute | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + |
Inflammation, Suppurative | |
Duct, Dilatation | 3 |
__________________________________________________________________________|
Prostate | + + + + + |
Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + |
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + |
__________________________________________________________________________|
Lymph Node | + |
Congestion | |
Inguinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + |
Congestion | 3 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + |
__________________________________________________________________________|
Spleen | + + + + + + |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Thymus | + + + M + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M M |
__________________________________________________________________________|
Skin | + + + + + + |
Alopecia | 2 |
Inflammation, Necrotizing | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 5| 4| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 4| 4| 7| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 1| 5| 3| 3| 3| 3| 5| 3| 5| 3| 3| 3| 5| 4| 2| 3| 3| 5| 3| 3|
| 3| 9| 3| 3| 3| 6| 9| 3| 3| 3| 3| 7| 3| 9| 3| 3| 3| 9| 3| 5| 3| 3| 9| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.01 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | M + + + + |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + |
Cerebellum, Infarct | |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | M |
Hemorrhage, Acute | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage, Multifocal | |
Infiltration Cellular, Lymphocyte | |
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Subacute | |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | |
Arteriole, Inflammation, Suppurative | |
Mucosa, Pigmentation | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Pigmentation | 2 2 1 2 2 1 2 2 1 1 2 2 1 2 2 2 1 2 2 1 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Pigmentation | 2 2 2 1 1 1 1 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Cyst | 3 |
Hydronephrosis | |
Inflammation, Suppurative | |
Metaplasia, Osseous | 3 |
Mineralization | |
Pelvis, Dilatation | 3 |
Renal Tubule, Degeneration | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + |
Concretion | |
Dilatation | 4 |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 6| 4| 6| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 0| 3| 3| 1| 5| 3| 8| 3| 3| 5| 1| 3| 3| 9| 5| 5| 5| 3| 3| 3| 3|
| 3| 3| 4| 9| 6| 3| 3| 7| 9| 3| 7| 3| 3| 9| 1| 3| 3| 7| 9| 5| 1| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0.01 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + |
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + |
Angiectasis | |
Cyst | |
Fibrosis | |
Focal Cellular Change | 3 |
Infarct | 4 |
Inflammation, Chronic | |
Inflammation, Subacute | 3 |
Necrosis, Acute | 4 |
__________________________________________________________________________|
Mesentery | + + + + |
Congestion | |
Inflammation, Suppurative | 4 |
Necrosis | 3 |
Fat, Necrosis | 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + |
Duct, Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + |
Hyperkeratosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + |
Necrosis | |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | 2 |
Inflammation, Suppurative | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + |
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M M M + + M + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 6| 4| 6| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 0| 3| 3| 1| 5| 3| 8| 3| 3| 5| 1| 3| 3| 9| 5| 5| 5| 3| 3| 3| 3|
| 3| 3| 4| 9| 6| 3| 3| 7| 9| 3| 7| 3| 3| 9| 1| 3| 3| 7| 9| 5| 1| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0.01 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + |
Serosa, Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Penis | + |
Concretion | 3 |
Hemorrhage, Acute | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + |
Inflammation, Suppurative | 4 |
Duct, Dilatation | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + +|
Dilatation | 2|
__________________________________________________________________________|
Testes | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + |
__________________________________________________________________________|
Lymph Node | + + |
Congestion | |
Inguinal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + M |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + |
Congestion | |
Hemorrhage | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + |
__________________________________________________________________________|
Spleen | + + + + + + + + |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | + M + + + + + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M + |
__________________________________________________________________________|
Skin | + + + + + + + + |
Alopecia | |
Inflammation, Necrotizing | |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 6| 4| 6| 4| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 0| 3| 3| 1| 5| 3| 8| 3| 3| 5| 1| 3| 3| 9| 5| 5| 5| 3| 3| 3| 3|
| 3| 3| 4| 9| 6| 3| 3| 7| 9| 3| 7| 3| 3| 9| 1| 3| 3| 7| 9| 5| 1| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
0.01 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
Cerebellum, Infarct | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | + |
Hemorrhage, Acute | 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Hemorrhage, Multifocal | |
Infiltration Cellular, Lymphocyte | 3 |
Infiltration Cellular, Histiocyte | |
Inflammation, Subacute | 1 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia | 2 |
Arteriole, Inflammation, Suppurative | |
Mucosa, Pigmentation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Pigmentation | 2 2 2 1 2 1 1 1 2 2 2 2 1 2 2 2 1 1 1 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Pigmentation | 2 1 1 1 1 1 2 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + +|
Cyst | 2|
Hydronephrosis | |
Inflammation, Suppurative | 4 4 |
Metaplasia, Osseous | |
Mineralization | |
Pelvis, Dilatation | |
Renal Tubule, Degeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + |
Concretion | |
Dilatation | 2 |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 6| 4| 4| 5| 7| | |
DAY ON TEST | 3| 3| 3| 8| 2| 8| 5| 5| 7| 3| | |
| 3| 3| 3| 9| 5| 2| 9| 9| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.01 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 17 |
__________________________________________________________________________|____________|
Gallbladder | + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 18 |
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 19 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 42 |
Angiectasis | | 1 4.0|
Cyst | | 1 3.0|
Fibrosis | | 1 3.0|
Focal Cellular Change | | 1 3.0|
Infarct | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
Inflammation, Subacute | | 1 3.0|
Necrosis, Acute | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | + | 5 |
Congestion | 3 | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
Necrosis | | 1 3.0|
Fat, Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + | 18 |
Duct, Cyst | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 17 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 29 |
Hyperkeratosis | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 26 |
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Developmental Malformation | | 2 2.0|
Inflammation, Suppurative | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 17 |
Inflammation, Subacute | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 6| 4| 4| 5| 7| | |
DAY ON TEST | 3| 3| 3| 8| 2| 8| 5| 5| 7| 3| | |
| 3| 3| 3| 9| 5| 2| 9| 9| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.01 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 17 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 17 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 17 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 12 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 16 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 19 |
Follicular Cell, Hyperplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + | 17 |
Serosa, Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Penis | + + | 3 |
Concretion | 3 | 2 3.0|
Hemorrhage, Acute | 4 | 1 4.0|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 5 |
Inflammation, Suppurative | | 1 4.0|
Duct, Dilatation | 3 | 3 3.3|
__________________________________________________________________________|____________|
Prostate | + + + + | 17 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 18 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + | 18 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 17 |
__________________________________________________________________________|____________|
Lymph Node | + + | 5 |
Congestion | 2 | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + | 27 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M | 13 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + | 22 |
Congestion | 2 | 2 2.5|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 6| 4| 4| 5| 7| | |
DAY ON TEST | 3| 3| 3| 8| 2| 8| 5| 5| 7| 3| | |
| 3| 3| 3| 9| 5| 2| 9| 9| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.01 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + | 18 |
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + | 16 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + M | 3 |
__________________________________________________________________________|____________|
Skin | + + + + | 18 |
Alopecia | | 1 2.0|
Inflammation, Necrotizing | 4 | 1 4.0|
Inflammation, Suppurative | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 16 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 17 |
Cerebellum, Infarct | 2 | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Hemorrhage, Acute | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 27 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 3 2.0|
Hemorrhage, Multifocal | 2 | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 3.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Inflammation, Subacute | | 1 1.0|
Metaplasia, Osseous | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Arteriole, Inflammation, Suppurative | 3 | 1 3.0|
Mucosa, Pigmentation | 1 | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Mucosa, Pigmentation | 1 2 2 1 1 1 1 2 | 52 1.6|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Mucosa, Pigmentation | 1 1 | 29 1.4|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 6| 4| 4| 5| 7| | |
DAY ON TEST | 3| 3| 3| 8| 2| 8| 5| 5| 7| 3| | |
| 3| 3| 3| 9| 5| 2| 9| 9| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.01 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 22 |
Cyst | | 2 2.5|
Hydronephrosis | 2 | 1 2.0|
Inflammation, Suppurative | | 2 4.0|
Metaplasia, Osseous | | 1 3.0|
Mineralization | 2 | 1 2.0|
Pelvis, Dilatation | 2 3 4 | 4 3.0|
Renal Tubule, Degeneration | 4 | 2 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 18 |
Concretion | 4 | 1 4.0|
Dilatation | 3 4 4 | 5 3.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 5| 3| 5| 3| 3| 0| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3|
| 2| 8| 2| 2| 2| 2| 2| 9| 2| 9| 2| 2| 7| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.05 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + |
__________________________________________________________________________|
Gallbladder | + + |
__________________________________________________________________________|
Intestine Large, Colon | + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + |
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
Cytoplasmic Alteration | 2 |
Focal Cellular Change | X |
Hematopoietic Cell Proliferation | |
Hyperplasia, Nodular | 2 |
__________________________________________________________________________|
Mesentery | + |
Congestion | 3 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + |
__________________________________________________________________________|
Salivary Glands | M + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + |
Cyst | |
Hyperkeratosis | |
Hyperplasia | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + |
__________________________________________________________________________|
Adrenal Medulla | + + |
__________________________________________________________________________|
Islets, Pancreatic | + + |
__________________________________________________________________________|
Parathyroid Gland | M + |
__________________________________________________________________________|
Pituitary Gland | + + |
__________________________________________________________________________|
Thyroid Gland | + + + + |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 5| 3| 5| 3| 3| 0| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3|
| 2| 8| 2| 2| 2| 2| 2| 9| 2| 9| 2| 2| 7| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.05 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Epididymis | + + |
__________________________________________________________________________|
Penis | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + |
Inflammation, Suppurative | |
Duct, Dilatation | 4 3 3 |
__________________________________________________________________________|
Prostate | + + |
__________________________________________________________________________|
Seminal Vesicle | + + + |
Dilatation | 2 |
__________________________________________________________________________|
Testes | + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + |
__________________________________________________________________________|
Lymph Node | + |
Iliac, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | M M |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Congestion | 3 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 4 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + |
__________________________________________________________________________|
Spleen | + + + + + |
Hematopoietic Cell Proliferation | 2 3 |
Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Thymus | + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M |
__________________________________________________________________________|
Skin | + + + |
Alopecia | 2 |
Hyperkeratosis | |
Inflammation, Suppurative | 4 3 |
Prepuce, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
Arthrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 1| 3| 3| 3| 3| 3| 5| 3| 5| 3| 3| 0| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3|
| 2| 8| 2| 2| 2| 2| 2| 9| 2| 9| 2| 2| 7| 2| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.05 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Mineralization | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Inflammation, Subacute | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolar Epithelium, Inflammation, | |
Subacute | |
Artery, Inflammation, Subacute | |
Mucosa, Pigmentation | 2 1 1 2 1 2 1 1 1 2 2 2 2 1 1 1 2 1 2 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Mucosa, Pigmentation | 4 3 3 3 3 4 2 2 3 2 3 2 3 3 2 3 2 2 2 2 2 3 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Pigmentation | 2 2 2 2 2 3 1 2 2 2 2 2 2 2 2 2 2 1 2 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + |
Inflammation, Chronic | |
Pelvis, Dilatation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
Dilatation | 3 2 2 3 2 |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 4| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 4| 4| 7|
DAY ON TEST | 5| 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 3| 1| 5| 5| 3|
| 9| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 9| 9| 2| 5| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.05 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + |
__________________________________________________________________________|
Gallbladder | + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + |
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | |
Cytoplasmic Alteration | 3 |
Focal Cellular Change | |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Nodular | 2 |
__________________________________________________________________________|
Mesentery | + |
Congestion | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + |
__________________________________________________________________________|
Salivary Glands | + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + |
Cyst | 2 |
Hyperkeratosis | 3 |
Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + |
__________________________________________________________________________|
Adrenal Medulla | + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + |
__________________________________________________________________________|
Parathyroid Gland | M + + |
__________________________________________________________________________|
Pituitary Gland | + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 4| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 4| 4| 7|
DAY ON TEST | 5| 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 3| 1| 5| 5| 3|
| 9| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 9| 9| 2| 5| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.05 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Epididymis | + + + |
__________________________________________________________________________|
Penis | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | |
Inflammation, Suppurative | |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + |
Dilatation | |
__________________________________________________________________________|
Testes | + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + |
Congestion | 3 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 4 3 |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + |
__________________________________________________________________________|
Spleen | + + + + + |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M |
__________________________________________________________________________|
Skin | + M + + + |
Alopecia | |
Hyperkeratosis | |
Inflammation, Suppurative | |
Prepuce, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + |
Arthrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 4| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 4| 4| 7|
DAY ON TEST | 5| 3| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 3| 1| 5| 5| 3|
| 9| 2| 9| 2| 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 9| 9| 9| 2| 5| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.05 PPM | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Mineralization | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 2 |
Inflammation, Subacute | |
Alveolar Epithelium, Hyperplasia | 2 2 2 |
Alveolar Epithelium, Inflammation, | |
Subacute | 2 |
Artery, Inflammation, Subacute | 3 |
Mucosa, Pigmentation | 1 1 2 1 2 1 1 1 1 1 1 1 1 1 2 1 1 2 1 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 |
Mucosa, Pigmentation | 3 2 2 3 2 3 3 2 2 2 3 2 3 3 3 3 3 2 2 3 3 3 3 2 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Pigmentation | 1 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + |
Inflammation, Chronic | 3 3 |
Pelvis, Dilatation | 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + |
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 6| 4| 7| 7| 7| | |
DAY ON TEST | 3| 3| 9| 3| 0| 2| 5| 3| 3| 3| | |
| 2| 2| 9| 2| 7| 0| 9| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.05 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 8 |
__________________________________________________________________________|____________|
Gallbladder | + M + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 9 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + | 47 |
Angiectasis | | 1 3.0|
Cyst | 3 | 1 3.0|
Cytoplasmic Alteration | | 2 2.5|
Focal Cellular Change | | 1 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia, Nodular | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Congestion | | 1 3.0|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + | 8 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 7 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 22 |
Cyst | | 1 2.0|
Hyperkeratosis | | 1 3.0|
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 18 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Developmental Malformation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 8 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 8 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 8 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 6 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 6| 4| 7| 7| 7| | |
DAY ON TEST | 3| 3| 9| 3| 0| 2| 5| 3| 3| 3| | |
| 2| 2| 9| 2| 7| 0| 9| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.05 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Follicular Cell, Hyperplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + | 8 |
__________________________________________________________________________|____________|
Penis | + | 1 |
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 4 |
Inflammation, Suppurative | 3 | 1 3.0|
Duct, Dilatation | | 3 3.3|
__________________________________________________________________________|____________|
Prostate | + + + | 8 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 9 |
Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + | 9 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node | | 3 |
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + | 16 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 13 |
Congestion | | 3 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | | 3 3.7|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 8 |
__________________________________________________________________________|____________|
Spleen | + + + | 13 |
Hematopoietic Cell Proliferation | | 3 2.7|
Hyperplasia, Lymphoid | | 3 3.0|
__________________________________________________________________________|____________|
Thymus | + + + | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M | |
__________________________________________________________________________|____________|
Skin | + + + + | 11 |
Alopecia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 6| 4| 7| 7| 7| | |
DAY ON TEST | 3| 3| 9| 3| 0| 2| 5| 3| 3| 3| | |
| 2| 2| 9| 2| 7| 0| 9| 2| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.05 PPM | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis | 2 | 1 2.0|
Inflammation, Suppurative | | 2 3.5|
Prepuce, Inflammation, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 9 |
Arthrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 8 |
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + | 18 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Hemorrhage | | 1 2.0|
Inflammation, Subacute | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 3 | 5 2.2|
Alveolar Epithelium, Inflammation, | | |
Subacute | | 1 2.0|
Artery, Inflammation, Subacute | | 1 3.0|
Mucosa, Pigmentation | 1 2 2 2 1 2 2 2 | 49 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 2 | 2 1.5|
Mucosa, Pigmentation | 3 2 2 2 2 2 2 3 2 2 | 60 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Mucosa, Pigmentation | 1 2 2 2 2 1 2 2 2 | 58 1.9|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 7 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 12 |
Inflammation, Chronic | | 2 3.0|
Pelvis, Dilatation | 2 | 4 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 17 |
Dilatation | 3 4 3 3 | 10 2.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 3| 4| 5| 7| 7| 7| 5| 6| 4| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 3| 2| 4| 5| 3| 3| 5| 5|
| 1| 1| 1| 9| 1| 1| 1| 5| 1| 1| 5| 1| 3| 9| 4| 1| 1| 1| 2| 2| 9| 1| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.2 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia | |
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Chronic | |
Peyer's Patch, Hyperplasia, Lymphoid | 2 3 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 3 |
Infarct | 4 |
Inflammation, Subacute | |
Mineralization | |
Necrosis, Acute | 3 |
__________________________________________________________________________|
Mesentery | + |
Necrosis | 4 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 3 2 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + M M + M + + M M M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 3| 4| 5| 7| 7| 7| 5| 6| 4| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 3| 2| 4| 5| 3| 3| 5| 5|
| 1| 1| 1| 9| 1| 1| 1| 5| 1| 1| 5| 1| 3| 9| 4| 1| 1| 1| 2| 2| 9| 1| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.2 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 1 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Granulomatous | 4 |
__________________________________________________________________________|
Penis | + |
Concretion | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + + + |
Duct, Dilatation | 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | |
Deep Cervical, Hematopoietic Cell | |
Proliferation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M M M + + + + M + + + M + M +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 3 4 |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +|
Congestion | 3 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 3 2 3 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M + M M M + M M M M M M M M M M M + M|
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 3| 4| 5| 7| 7| 7| 5| 6| 4| 7| 7| 4| 4|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 3| 2| 4| 5| 3| 3| 5| 5|
| 1| 1| 1| 9| 1| 1| 1| 5| 1| 1| 5| 1| 3| 9| 4| 1| 1| 1| 2| 2| 9| 1| 1| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.2 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Inflammation, Suppurative | 3 |
Mineralization | 2 2 2 2 2 2 3 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Subacute | 3 3 1 |
Inflammation, Suppurative | 4 4 |
Alveolar Epithelium, Hyperplasia | 2 2 |
Bronchiole, Hyperplasia | |
Mucosa, Pigmentation | 3 2 2 1 2 2 1 2 2 2 2 2 3 2 2 2 1 3 3 2 2 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 3 1 1 2 1 1 2 4 4 2 1 4 3 1 2 1 3|
Mucosa, Pigmentation | 1 3 2 3 2 2 2 4 2 3 3 2 3 1 1 3 2 2 2 2 2 4|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Mucosa, Pigmentation | 3 2 3 2 2 2 2 2 2 2 2 2 3 1 2 2 2 2 2 3 2 2 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | |
Inflammation, Subacute | |
Metaplasia, Osseous | 2 |
Mineralization | 2 |
Nephropathy, Chronic | 4 |
Pelvis, Dilatation | |
Renal Tubule, Degeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 4| 4| 7| 7| 5| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 6| 5| 1| 3| 4| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 1| 0|
| 1| 1| 0| 9| 7| 1| 2| 1| 1| 9| 1| 1| 1| 3| 1| 1| 1| 1| 1| 1| 1| 6| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.2 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia | 4 |
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Chronic | 3|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 2 3 |
Infarct | |
Inflammation, Subacute | 2 |
Mineralization | 2 |
Necrosis, Acute | 2 |
__________________________________________________________________________|
Mesentery | |
Necrosis | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
__________________________________________________________________________|
Tooth | + + |
Developmental Malformation | 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Arteriole, Mineralization | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + M + + M M + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 4| 4| 7| 7| 5| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 6| 5| 1| 3| 4| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 1| 0|
| 1| 1| 0| 9| 7| 1| 2| 1| 1| 9| 1| 1| 1| 3| 1| 1| 1| 1| 1| 1| 1| 6| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.2 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 4 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Penis | + |
Concretion | 4 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Preputial Gland | |
Duct, Dilatation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + |
Deep Cervical, Hematopoietic Cell | |
Proliferation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + M + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 4 4 4 |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Hematopoietic Cell Proliferation | 4|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 3 3 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M + M M M M M M M M M M M M M M M M M M M M M|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 4| 4| 7| 7| 5| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 3| 6| 5| 1| 3| 4| 3| 3| 5| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 2| 3| 1| 0|
| 1| 1| 0| 9| 7| 1| 2| 1| 1| 9| 1| 1| 1| 3| 1| 1| 1| 1| 1| 1| 1| 6| 1| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.2 PPM | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 3 |
Inflammation, Suppurative | |
Mineralization | 2 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Subacute | |
Inflammation, Suppurative | 4 |
Alveolar Epithelium, Hyperplasia | 3 2 3 3 |
Bronchiole, Hyperplasia | 3 |
Mucosa, Pigmentation | 2 2 2 3 2 2 3 2 3 2 3 3 2 2 2 2 2 2 2 2 2 2 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 2 4 4 2 3 2 2 3 2 3 3 2 3 2 2 2 2|
Mucosa, Pigmentation | 2 2 2 2 2 4 2 2 4 2 1 3 2 1 3 2 2 2 3 2 3 3 3|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Mucosa, Pigmentation | 2 2 2 3 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 3|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 |
Inflammation, Chronic | 4 |
Inflammation, Subacute | 3 2 |
Metaplasia, Osseous | |
Mineralization | 2 2 |
Nephropathy, Chronic | |
Pelvis, Dilatation | 3 |
Renal Tubule, Degeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 4 3 |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 7| 5| 4| 4| 6| | |
DAY ON TEST | 5| 3| 5| 3| 3| 3| 5| 5| 8| 6| | |
| 9| 1| 9| 1| 1| 1| 5| 9| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.2 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
Congestion | 3 | 1 3.0|
Hyperplasia | | 1 4.0|
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Congestion | 3 | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Peyer's Patch, Hyperplasia, Lymphoid | | 3 2.7|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Congestion | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Cytoplasmic Alteration | 2 | 4 2.5|
Infarct | | 1 4.0|
Inflammation, Subacute | | 1 2.0|
Mineralization | | 1 2.0|
Necrosis, Acute | | 2 2.5|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Necrosis | | 1 4.0|
Fat, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperkeratosis | | 4 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Mineralization | | 2 2.0|
__________________________________________________________________________|____________|
Tooth | | 2 |
Developmental Malformation | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Arteriole, Mineralization | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 7| 5| 4| 4| 6| | |
DAY ON TEST | 5| 3| 5| 3| 3| 3| 5| 5| 8| 6| | |
| 9| 1| 9| 1| 1| 1| 5| 9| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.2 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + M + + M + | 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Hyperplasia | | 5 2.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Inflammation, Chronic | 4 | 1 4.0|
Inflammation, Granulomatous | | 1 4.0|
__________________________________________________________________________|____________|
Penis | + | 3 |
Concretion | | 1 4.0|
Inflammation, Suppurative | 4 | 2 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 4 |
Duct, Dilatation | 4 | 3 3.7|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
Deep Cervical, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 52 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 5 3.8|
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Congestion | | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 7| 5| 4| 4| 6| | |
DAY ON TEST | 5| 3| 5| 3| 3| 3| 5| 5| 8| 6| | |
| 9| 1| 9| 1| 1| 1| 5| 9| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.2 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hematopoietic Cell Proliferation | | 1 4.0|
Hemorrhage | | 2 3.0|
Hyperplasia, Lymphoid | | 7 2.9|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | | 3 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Inflammation, Subacute | | 1 3.0|
Inflammation, Suppurative | | 1 3.0|
Mineralization | 2 | 15 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 3 4 | 2 3.5|
Inflammation, Subacute | | 3 2.3|
Inflammation, Suppurative | 4 | 4 4.0|
Alveolar Epithelium, Hyperplasia | | 6 2.5|
Bronchiole, Hyperplasia | | 1 3.0|
Mucosa, Pigmentation | 2 2 2 2 3 2 2 3 1 2 | 55 2.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 3 2 3 2 2 2 3 3 2 | 46 2.3|
Mucosa, Pigmentation | 2 2 3 2 3 2 2 3 3 | 54 2.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 4 | 2 3.0|
Mucosa, Pigmentation | 3 2 2 2 3 2 2 2 2 2 | 58 2.1|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 4| 7| 4| 7| 7| 7| 5| 4| 4| 6| | |
DAY ON TEST | 5| 3| 5| 3| 3| 3| 5| 5| 8| 6| | |
| 9| 1| 9| 1| 1| 1| 5| 9| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| | A |
0.2 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| | L |
| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | | 3 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 3 2.0|
Inflammation, Chronic | | 1 4.0|
Inflammation, Subacute | | 2 2.5|
Metaplasia, Osseous | | 1 2.0|
Mineralization | 2 | 4 2.0|
Nephropathy, Chronic | | 1 4.0|
Pelvis, Dilatation | 3 | 2 3.0|
Renal Tubule, Degeneration | 4 | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Dilatation | 3 | 4 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 6| 7| 2| 4| 2| 7| 6| 2| 7| 4| 2| 2| 7| 2| 2| 2| 6| 7| 2| 7|
DAY ON TEST | 3| 9| 4| 1| 3| 2| 3| 3| 5| 9| 3| 1| 9| 3| 5| 3| 9| 3| 3| 9| 9| 2| 3| 3| 3|
| 0| 6| 5| 7| 0| 6| 0| 2| 9| 5| 0| 6| 5| 0| 9| 2| 5| 0| 2| 5| 5| 6| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.2 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
SE33 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + |
Cytoplasmic Alteration | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + |
Congestion | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + |
Congestion | 1 |
__________________________________________________________________________|
Tooth | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + M + + + M + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + |
__________________________________________________________________________|
Prostate | + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + |
Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 6| 7| 2| 4| 2| 7| 6| 2| 7| 4| 2| 2| 7| 2| 2| 2| 6| 7| 2| 7|
DAY ON TEST | 3| 9| 4| 1| 3| 2| 3| 3| 5| 9| 3| 1| 9| 3| 5| 3| 9| 3| 3| 9| 9| 2| 3| 3| 3|
| 0| 6| 5| 7| 0| 6| 0| 2| 9| 5| 0| 6| 5| 0| 9| 2| 5| 0| 2| 5| 5| 6| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.2 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
SE33 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M M M + M M M + M M M M + M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + |
Mineralization | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 2 |
Infiltration Cellular, Histiocyte | |
Inflammation, Subacute | |
Pigmentation | 1 |
Alveolar Epithelium, Hyperplasia | |
Interstitium, Inflammation | 3 |
Mucosa, Pigmentation | 2 2 2 2 2 1 2 2 2 2 2 2 3 2 3 2 2 3 2 2 1 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Inflammation, Suppurative | 2 2 2 2 1 |
Mucosa, Pigmentation | 3 4 3 2 2 1 3 1 4 3 3 2 3 3 2 1 3 2 1 3 3 2 2 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Pigmentation | 2 2 2 2 2 3 2 3 2 3 2 2 3 2 4 2 2 2 2 3 3 2 2 2 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + |
Inflammation, Subacute | |
Renal Tubule, Cytoplasmic Alteration | |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 6| 7| 2| 4| 2| 7| 6| 2| 7| 4| 2| 2| 7| 2| 2| 2| 6| 7| 2| 7|
DAY ON TEST | 3| 9| 4| 1| 3| 2| 3| 3| 5| 9| 3| 1| 9| 3| 5| 3| 9| 3| 3| 9| 9| 2| 3| 3| 3|
| 0| 6| 5| 7| 0| 6| 0| 2| 9| 5| 0| 6| 5| 0| 9| 2| 5| 0| 2| 5| 5| 6| 0| 2| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.2 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
SE33 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 2| 7| 2| 7| 2| 7| 4| 2| 7| 4| 7| 7| 7| 2| 5| 4| 7| 6| 4| 7| 7| 2| 2| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 2| 3| 5| 9| 3| 5| 3| 3| 3| 3| 2| 5| 3| 2| 5| 3| 3| 3| 9| 3| 3|
| 5| 0| 2| 0| 0| 0| 9| 5| 0| 9| 1| 1| 1| 2| 1| 9| 1| 8| 9| 1| 1| 2| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
SE33 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + |
Cytoplasmic Alteration | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + |
Congestion | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + |
Congestion | |
__________________________________________________________________________|
Tooth | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + |
__________________________________________________________________________|
Prostate | + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + |
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 2| 7| 2| 7| 2| 7| 4| 2| 7| 4| 7| 7| 7| 2| 5| 4| 7| 6| 4| 7| 7| 2| 2| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 2| 3| 5| 9| 3| 5| 3| 3| 3| 3| 2| 5| 3| 2| 5| 3| 3| 3| 9| 3| 3|
| 5| 0| 2| 0| 0| 0| 9| 5| 0| 9| 1| 1| 1| 2| 1| 9| 1| 8| 9| 1| 1| 2| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
SE33 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M M + + + M |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Infiltration Cellular, Histiocyte | |
Inflammation, Subacute | |
Pigmentation | |
Alveolar Epithelium, Hyperplasia | 2 3 |
Interstitium, Inflammation | |
Mucosa, Pigmentation | 2 2 1 2 3 2 3 3 2 2 2 3 2 1 2 3 2 2 3 2 2 1 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Inflammation, Suppurative | 1 2 1 |
Mucosa, Pigmentation | 2 2 1 2 2 2 2 3 2 2 2 2 2 1 2 2 2 2 2 2 2 1 4 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Pigmentation | 4 1 2 2 2 2 2 3 2 2 2 2 2 2 2 3 1 2 3 2 2 2 4 2 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + |
Inflammation, Subacute | |
Renal Tubule, Cytoplasmic Alteration | |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 2| 7| 2| 7| 2| 7| 4| 2| 7| 4| 7| 7| 7| 2| 5| 4| 7| 6| 4| 7| 7| 2| 2| 7| 7|
DAY ON TEST | 9| 3| 3| 3| 2| 3| 5| 9| 3| 5| 3| 3| 3| 3| 2| 5| 3| 2| 5| 3| 3| 3| 9| 3| 3|
| 5| 0| 2| 0| 0| 0| 9| 5| 0| 9| 1| 1| 1| 2| 1| 9| 1| 8| 9| 1| 1| 2| 5| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2 PPM | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
SE33 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 2| 2| 7| 4| 4| 7| 7| 7| 2| 2| 6| 2| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 3| 9| 3| 5| 9| 3| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3| 1| 5|
| 2| 2| 1| 9| 9| 1| 1| 1| 5| 2| 3| 5| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
SE33 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Gallbladder | + M + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + |
__________________________________________________________________________|
Liver | + + + + + |
Cytoplasmic Alteration | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + |
Congestion | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + |
Congestion | |
__________________________________________________________________________|
Tooth | + |
Inflammation, Suppurative | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + |
__________________________________________________________________________|
Adrenal Medulla | + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + + + M + M + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + |
Cyst | 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + |
__________________________________________________________________________|
Prostate | + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + |
__________________________________________________________________________|
Testes | + + + + + |
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 2| 2| 7| 4| 4| 7| 7| 7| 2| 2| 6| 2| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 3| 9| 3| 5| 9| 3| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3| 1| 5|
| 2| 2| 1| 9| 9| 1| 1| 1| 5| 2| 3| 5| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
SE33 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + M |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + + + + + + + + + M + + M M + + |
__________________________________________________________________________|
Spleen | + + + + + |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M M M M M M M M M + M M M M M M M M M M |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Histiocyte | 2 |
Inflammation, Subacute | 2 |
Pigmentation | |
Alveolar Epithelium, Hyperplasia | 3 2 3 |
Interstitium, Inflammation | |
Mucosa, Pigmentation | 1 1 2 2 2 2 2 2 3 1 2 3 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Inflammation, Suppurative | 1 3 |
Mucosa, Pigmentation | 1 2 2 3 3 2 2 2 4 1 3 2 2 2 2 2 3 2 2 2 2 2 2 3 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Pigmentation | 2 2 2 2 3 2 2 2 4 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + |
Inflammation, Subacute | 1 |
Renal Tubule, Cytoplasmic Alteration | 2 |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 2| 2| 7| 4| 4| 7| 7| 7| 2| 2| 6| 2| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 3| 3| 5| 5| 3| 3| 3| 9| 3| 5| 9| 3| 3| 3| 3| 5| 3| 3| 6| 3| 3| 3| 1| 5|
| 2| 2| 1| 9| 9| 1| 1| 1| 5| 2| 3| 5| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2 PPM | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
SE33 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + |
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 6| | |
DAY ON TEST | 3| 4| 3| 3| 4| | |
| 1| 2| 4| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
0.2 PPM | 8| 8| 8| 8| 8| | L |
SE33 | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 69 |
__________________________________________________________________________|____________|
Gallbladder | | 17 |
__________________________________________________________________________|____________|
Intestine Large, Colon | | 20 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 20 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 20 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | | 20 |
__________________________________________________________________________|____________|
Liver | + | 21 |
Cytoplasmic Alteration | | 4 2.0|
__________________________________________________________________________|____________|
Pancreas | | 20 |
__________________________________________________________________________|____________|
Salivary Glands | | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | | 20 |
Congestion | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | | 20 |
Congestion | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation, Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 20 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | | 20 |
__________________________________________________________________________|____________|
Adrenal Medulla | | 20 |
__________________________________________________________________________|____________|
Islets, Pancreatic | | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + | 59 |
__________________________________________________________________________|____________|
Pituitary Gland | | 20 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 67 |
Cyst | | 2 2.0|
Follicular Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | | 20 |
__________________________________________________________________________|____________|
Prostate | | 20 |
__________________________________________________________________________|____________|
Seminal Vesicle | | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 6| | |
DAY ON TEST | 3| 4| 3| 3| 4| | |
| 1| 2| 4| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
0.2 PPM | 8| 8| 8| 8| 8| | L |
SE33 | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | | 20 |
Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + | 59 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + | 78 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | | 15 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 20 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 64 |
__________________________________________________________________________|____________|
Spleen | | 20 |
__________________________________________________________________________|____________|
Thymus | + + + + + | 68 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + M M M | 8 |
__________________________________________________________________________|____________|
Skin | + + + + + | 68 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 59 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | | 20 |
Mineralization | | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + | 80 |
__________________________________________________________________________|____________|
Lung | + + + + + | 78 |
Congestion | | 4 2.0|
Infiltration Cellular, Histiocyte | | 1 2.0|
Inflammation, Subacute | 3 | 2 2.5|
Pigmentation | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 5 2.6|
Interstitium, Inflammation | | 1 3.0|
Mucosa, Pigmentation | 2 2 2 | 74 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 80 |
Inflammation, Subacute | 1 | 1 1.0|
Inflammation, Suppurative | | 10 1.7|
Mucosa, Pigmentation | 2 2 2 2 2 | 80 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 6| | |
DAY ON TEST | 3| 4| 3| 3| 4| | |
| 1| 2| 4| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| | A |
0.2 PPM | 8| 8| 8| 8| 8| | L |
SE33 | 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + | 80 |
Mucosa, Pigmentation | 2 2 2 2 2 | 80 2.2|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | | 20 |
Inflammation, Subacute | | 1 1.0|
Renal Tubule, Cytoplasmic Alteration | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 2| 7| 5| 7| 7| 7| 7| 7| 6| 6| 6| 6| 3| 7|
DAY ON TEST | 3| 3| 3| 0| 3| 3| 5| 3| 3| 3| 2| 5| 3| 2| 3| 3| 3| 3| 3| 5| 5| 4| 2| 2| 3|
| 0| 0| 0| 6| 0| 0| 2| 0| 0| 0| 3| 5| 0| 6| 0| 0| 0| 0| 0| 6| 4| 7| 2| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.2 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4|
SE65 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Parathyroid Gland | + + + M M + + + + + + + + + + + + M M + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + +|
Crystals | 2 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 3 |
Inflammation, Subacute | 2 |
Alveolar Epithelium, Hyperplasia | 3 |
Arteriole, Bacterium | 4 |
Mucosa, Pigmentation | 3 2 2 2 2 2 2 2 2 2 2 2 2 1 2 3 2 1 2 2 2|
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 2| 7| 5| 7| 7| 7| 7| 7| 6| 6| 6| 6| 3| 7|
DAY ON TEST | 3| 3| 3| 0| 3| 3| 5| 3| 3| 3| 2| 5| 3| 2| 3| 3| 3| 3| 3| 5| 5| 4| 2| 2| 3|
| 0| 0| 0| 6| 0| 0| 2| 0| 0| 0| 3| 5| 0| 6| 0| 0| 0| 0| 0| 6| 4| 7| 2| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.2 PPM | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4|
SE65 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Inflammation, Suppurative | 1 2 2 3 2 3 2 2 4|
Mucosa, Pigmentation | 3 2 2 3 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 3 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Pigmentation | 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 3 2 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 5| 3| 3| 3| 3| 1| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 5| 3| 3| |
| 0| 3| 0| 0| 0| 0| 8| 4| 0| 0| 0| 9| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 7| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| A |
0.2 PPM | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| L |
SE65 | 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Developmental Malformation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + M + M M M M + + M + M M M M + + + + M| 30 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + +| 45 |
Crystals | | 1 2.0|
Follicular Cell, Hyperplasia | 2 1 2| 4 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +| 35 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + M + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M + M M M M M M M M M M M M M + M M| 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + +| 35 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 4 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 7| |
DAY ON TEST | 3| 5| 3| 3| 3| 3| 1| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3| 1| 7| 3| 3| 3| 5| 3| 3| |
| 0| 3| 0| 0| 0| 0| 8| 4| 0| 0| 0| 9| 0| 0| 0| 0| 0| 0| 1| 0| 0| 0| 7| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| A |
0.2 PPM | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| L |
SE65 | 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | | 1 3.0|
Inflammation, Subacute | 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.5|
Arteriole, Bacterium | | 1 4.0|
Mucosa, Pigmentation | 2 2 2 2 2 2 2 1 2 2 1 2 2 2 2 2 1 2 2 2 2 1 2 2| 45 1.9|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Subacute | | 1 2.0|
Inflammation, Suppurative | 2 2 3 4 4 2 3 2 | 17 2.5|
Mucosa, Pigmentation | 1 2 2 3 2 2 3 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2| 46 2.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Mucosa, Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2| 48 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 3| 2| 7| 7| 2| 2| 7| 7| 7| 7| 1| 1| 2| 2| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 2| 2| 7| 2| 8| 9| 2| 2| 9| 9| 0| 2| 2| 2| 8| 8| 3| 3| 2| 2| 2| 2| 0| 2| 2|
| 9| 9| 5| 9| 1| 5| 9| 9| 5| 5| 3| 9| 9| 9| 3| 3| 2| 2| 9| 9| 9| 9| 5| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6|
SE26 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | M + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | M + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + |
__________________________________________________________________________|
Liver | + + + + + |
Congestion | |
__________________________________________________________________________|
Pancreas | + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + |
Congestion | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + |
Congestion | |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + |
__________________________________________________________________________|
Adrenal Medulla | + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + M + + + M M + + + M M M + + M + M M M M M M M|
__________________________________________________________________________|
Pituitary Gland | + + + M + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 4 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + |
__________________________________________________________________________|
Prostate | + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + |
__________________________________________________________________________|
Testes | + + + + + |
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + + + M + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 3| 2| 7| 7| 2| 2| 7| 7| 7| 7| 1| 1| 2| 2| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 2| 2| 7| 2| 8| 9| 2| 2| 9| 9| 0| 2| 2| 2| 8| 8| 3| 3| 2| 2| 2| 2| 0| 2| 2|
| 9| 9| 5| 9| 1| 5| 9| 9| 5| 5| 3| 9| 9| 9| 3| 3| 2| 2| 9| 9| 9| 9| 5| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6|
SE26 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + |
Mineralization | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Hyperplasia, Macrophage | |
Inflammation, Subacute | |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 4 |
Mucosa, Pigmentation | 2 2 1 2 2 3 1 1 2 3 2 2 2 2 2 1 2 3 2 2 2 3 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 4 2 |
Mucosa, Pigmentation | 2 1 1 2 1 1 1 1 1 2 2 1 2 1 2 1 1 2 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + A + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Mucosa, Pigmentation | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 1 2 2 2 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + |
Inflammation, Subacute | |
__________________________________________________________________________|
Urinary Bladder | + + + + + |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 2| 1| 7| 4| 4| 7| 2| 7| 1| 7| 1| 7| 7| 2| 2| 2| 4| 2| 4| 7| 4| 4| 1| 7|
DAY ON TEST | 2| 9| 8| 2| 5| 5| 2| 3| 2| 8| 2| 8| 2| 2| 9| 3| 9| 9| 3| 5| 2| 5| 5| 8| 2|
| 9| 5| 3| 9| 8| 8| 9| 2| 9| 3| 9| 3| 9| 9| 5| 2| 5| 4| 2| 8| 9| 8| 8| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 PPM | 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2|
SE26 | 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + |
Congestion | |
__________________________________________________________________________|
Pancreas | + + + + + + |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + |
Congestion | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + |
Congestion | |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | M + + M M + M + M + + + + + + + M M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 4 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + M + M |
__________________________________________________________________________|
Prostate | + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + |
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 2| 1| 7| 4| 4| 7| 2| 7| 1| 7| 1| 7| 7| 2| 2| 2| 4| 2| 4| 7| 4| 4| 1| 7|
DAY ON TEST | 2| 9| 8| 2| 5| 5| 2| 3| 2| 8| 2| 8| 2| 2| 9| 3| 9| 9| 3| 5| 2| 5| 5| 8| 2|
| 9| 5| 3| 9| 8| 8| 9| 2| 9| 3| 9| 3| 9| 9| 5| 2| 5| 4| 2| 8| 9| 8| 8| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 PPM | 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2|
SE26 | 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + M M |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Spleen | + + + + + + |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M + M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Macrophage | |
Inflammation, Subacute | 4 3 2 3|
Inflammation, Suppurative | 1 |
Alveolar Epithelium, Hyperplasia | 2 2 |
Mucosa, Pigmentation | 2 2 2 2 2 2 2 2 1 2 1 2 2 2 3 2 2 3 2 3 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 4 2 2 2 2 |
Mucosa, Pigmentation | 1 1 2 2 1 1 1 2 1 1 1 1 2 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 |
Mucosa, Pigmentation | 2 3 2 2 2 2 2 3 1 2 3 2 2 1 2 3 1 2 2 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + |
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 108
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 2| 2| 7| 4| 7| 1| 2| 7| 7| 4| 7| 7| 4| 7| 7| 5| 4| 7| 6| 7| 1| 7| 2| 1| 2|
DAY ON TEST | 3| 9| 2| 5| 2| 8| 9| 2| 2| 5| 3| 3| 5| 3| 3| 7| 5| 3| 1| 3| 8| 3| 9| 8| 3|
| 2| 5| 9| 8| 9| 3| 5| 9| 9| 8| 0| 0| 8| 0| 0| 0| 8| 0| 2| 0| 3| 0| 5| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 PPM | 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|
SE26 | 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + +|
__________________________________________________________________________|
Liver | + + + + +|
Congestion | |
__________________________________________________________________________|
Pancreas | + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + +|
Congestion | 1|
__________________________________________________________________________|
Stomach, Glandular | + + + + +|
Congestion | 1|
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + +|
__________________________________________________________________________|
Adrenal Medulla | M + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + M M + + + + + M + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + +|
__________________________________________________________________________|
Prostate | + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + +|
__________________________________________________________________________|
Testes | + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 109
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 2| 2| 7| 4| 7| 1| 2| 7| 7| 4| 7| 7| 4| 7| 7| 5| 4| 7| 6| 7| 1| 7| 2| 1| 2|
DAY ON TEST | 3| 9| 2| 5| 2| 8| 9| 2| 2| 5| 3| 3| 5| 3| 3| 7| 5| 3| 1| 3| 8| 3| 9| 8| 3|
| 2| 5| 9| 8| 9| 3| 5| 9| 9| 8| 0| 0| 8| 0| 0| 0| 8| 0| 2| 0| 3| 0| 5| 3| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 PPM | 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8|
SE26 | 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + + + + + + + + + M + + + M + + +|
__________________________________________________________________________|
Spleen | + + + + +|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Macrophage | 3 |
Inflammation, Subacute | 2 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 2 |
Mucosa, Pigmentation | 2 1 2 3 2 1 3 2 2 3 2 2 2 2 2 2 2 2 1 2 1 2 2 1 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 3 2 2 2 3 2 2 4|
Mucosa, Pigmentation | 2 1 1 1 1 2 2 2 2 2 1 2 2 2 2 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Mucosa, Pigmentation | 2 2 2 2 2 1 3 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 1 3|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + +|
Inflammation, Subacute | 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + +|
_____________________________________________________________________________________________________________________|
Page 110
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 2| 7| 7| 7| 4| 1| 7| 7| 2| 7| 7| 2| 2| 7| 7| | |
DAY ON TEST | 9| 3| 3| 3| 5| 8| 3| 2| 3| 0| 3| 3| 3| 3| 3| | |
| 5| 0| 0| 0| 8| 3| 0| 5| 2| 3| 0| 2| 2| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.5 PPM | 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| | L |
SE26 | 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + | 79 |
__________________________________________________________________________|____________|
Gallbladder | + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 20 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 19 |
__________________________________________________________________________|____________|
Liver | + + + + | 20 |
Congestion | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + | 20 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 20 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 20 |
Congestion | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 20 |
Congestion | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Developmental Malformation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 20 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 20 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 19 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 20 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + M + + + + | 52 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 19 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + | 79 |
Follicular Cell, Hyperplasia | | 7 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + | 18 |
__________________________________________________________________________|____________|
Prostate | + + + + | 20 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 20 |
__________________________________________________________________________|____________|
Testes | + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 111
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 2| 7| 7| 7| 4| 1| 7| 7| 2| 7| 7| 2| 2| 7| 7| | |
DAY ON TEST | 9| 3| 3| 3| 5| 8| 3| 2| 3| 0| 3| 3| 3| 3| 3| | |
| 5| 0| 0| 0| 8| 3| 0| 5| 2| 3| 0| 2| 2| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.5 PPM | 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| | L |
SE26 | 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + | 67 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + | 87 |
Hyperplasia, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M | 14 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 19 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + | 75 |
__________________________________________________________________________|____________|
Spleen | + + + + | 20 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + | 78 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M + M M M | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + M + + + + | 68 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + | 67 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 20 |
Mineralization | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + | 90 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 89 |
Congestion | | 1 1.0|
Hyperplasia, Macrophage | 4 | 2 3.5|
Inflammation, Subacute | | 5 2.8|
Inflammation, Suppurative | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 5 2.4|
Mucosa, Pigmentation | 2 2 2 2 1 3 1 3 2 2 1 3 2 2 | 85 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 90 |
Inflammation, Suppurative | 3 2 1 | 21 2.5|
Mucosa, Pigmentation | 1 1 1 1 1 1 | 61 1.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 87 |
Inflammation, Suppurative | | 2 1.5|
Mucosa, Pigmentation | 2 2 2 2 3 3 2 2 1 2 2 1 2 2 | 86 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 112
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 2| 7| 7| 7| 4| 1| 7| 7| 2| 7| 7| 2| 2| 7| 7| | |
DAY ON TEST | 9| 3| 3| 3| 5| 8| 3| 2| 3| 0| 3| 3| 3| 3| 3| | |
| 5| 0| 0| 0| 8| 3| 0| 5| 2| 3| 0| 2| 2| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.5 PPM | 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| | L |
SE26 | 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 20 |
Inflammation, Subacute | | 3 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 20 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 113
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 4| 2| 2| 2| 4| 2| 4| 2| 4| 7| 7| 7| 2| 7| 7| 2| 6| 7| 7| 7| 7| 6| 7| 7| 2|
DAY ON TEST | 5| 9| 9| 7| 5| 9| 5| 4| 5| 2| 2| 2| 9| 2| 2| 4| 2| 2| 2| 2| 2| 0| 2| 2| 9|
| 8| 5| 5| 4| 8| 5| 8| 5| 8| 9| 9| 9| 5| 9| 9| 7| 6| 9| 9| 9| 9| 1| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
SE42 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + +|
__________________________________________________________________________|
Liver | + + + + +|
__________________________________________________________________________|
Pancreas | + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 3 3 1 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + +|
__________________________________________________________________________|
Prostate | + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + +|
__________________________________________________________________________|
Testes | + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + + + + + + M + + M + + + + + + + + +|
Hyperplasia, Lymphoid | 4 3 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + +|
_____________________________________________________________________________________________________________________|
Page 114
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 4| 2| 2| 2| 4| 2| 4| 2| 4| 7| 7| 7| 2| 7| 7| 2| 6| 7| 7| 7| 7| 6| 7| 7| 2|
DAY ON TEST | 5| 9| 9| 7| 5| 9| 5| 4| 5| 2| 2| 2| 9| 2| 2| 4| 2| 2| 2| 2| 2| 0| 2| 2| 9|
| 8| 5| 5| 4| 8| 5| 8| 5| 8| 9| 9| 9| 5| 9| 9| 7| 6| 9| 9| 9| 9| 1| 9| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5 PPM | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
SE42 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + +|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + +|
Alopecia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + +|
Mineralization | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchiectasis | |
Congestion | 2 |
Inflammation, Subacute | 3 2 2 |
Inflammation, Suppurative | 4 3 4 4 4 2 4|
Mineralization | |
Alveolar Epithelium, Hyperplasia | 3 3 |
Mucosa, Pigmentation | 1 2 3 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 4 4 3 3 3 3 3 2 3 2 4 3 2 4|
Mucosa, Pigmentation | 1 3 1 3 1 2 2 2 2 2 2 2 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 3 |
Inflammation, Suppurative | 1 3 4 2 1 3 2|
Mucosa, Pigmentation | 2 1 2 2 2 1 2 2 1 1 2 2 2 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + +|
_____________________________________________________________________________________________________________________|
Page 115
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 2| 7| 7| 7| 2| 7| 7| 6| 7| 2| 7| 4| 7| 4| 2| 2| 7| 7| 7| 4| 7|
DAY ON TEST | 2| 5| 2| 2| 9| 1| 2| 2| 9| 2| 2| 4| 2| 1| 2| 5| 2| 8| 6| 9| 2| 2| 2| 5| 2|
| 9| 7| 9| 9| 5| 7| 9| 9| 5| 9| 9| 7| 9| 9| 9| 8| 9| 7| 2| 5| 9| 9| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.5 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2|
SE42 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + |
__________________________________________________________________________|
Liver | + + + |
__________________________________________________________________________|
Pancreas | + + + |
__________________________________________________________________________|
Salivary Glands | + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + |
Inflammation, Subacute | |
__________________________________________________________________________|
Tooth | + + |
Developmental Malformation | 4 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + |
__________________________________________________________________________|
Adrenal Medulla | + + + |
__________________________________________________________________________|
Islets, Pancreatic | + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 1 3 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + |
__________________________________________________________________________|
Prostate | + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + |
__________________________________________________________________________|
Testes | + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
_____________________________________________________________________________________________________________________|
Page 116
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
_____________________________________________________________________________________________________________________
| 7| 2| 7| 7| 2| 7| 7| 7| 2| 7| 7| 6| 7| 2| 7| 4| 7| 4| 2| 2| 7| 7| 7| 4| 7|
DAY ON TEST | 2| 5| 2| 2| 9| 1| 2| 2| 9| 2| 2| 4| 2| 1| 2| 5| 2| 8| 6| 9| 2| 2| 2| 5| 2|
| 9| 7| 9| 9| 5| 7| 9| 9| 5| 9| 9| 7| 9| 9| 9| 8| 9| 7| 2| 5| 9| 9| 9| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.5 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2|
SE42 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 4 |
__________________________________________________________________________|
Spleen | + + + |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 4 3 3 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchiectasis | 4 4 |
Congestion | |
Inflammation, Subacute | 2 3 4 |
Inflammation, Suppurative | 4 4 3 4 4 4 3 2 2 |
Mineralization | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 2 |
Mucosa, Pigmentation | 2 2 2 1 3 2 3 2 2 2 2 2 2 2 2 1 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 3 3 2 3 2 3 4 2 4 2 3 2 3 2 2 3 2|
Mucosa, Pigmentation | 1 1 2 1 1 1 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 3 2 |
Inflammation, Suppurative | 2 4 3 3 2 2 |
Mucosa, Pigmentation | 2 2 2 2 2 1 2 2 2 1 2 2 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + |
__________________________________________________________________________|
Urinary Bladder | + + + |
_____________________________________________________________________________________________________________________|
Page 117
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 2| 3| 4| 2| 7| 7| 7| 4| 7| 2| 6| 3| 4| 2| 7| 7| 6| | |
DAY ON TEST | 5| 2| 2| 9| 2| 5| 9| 2| 2| 2| 5| 2| 9| 5| 9| 5| 9| 2| 2| 6| | |
| 8| 9| 9| 5| 0| 8| 1| 9| 9| 9| 8| 9| 5| 2| 5| 8| 2| 9| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| | L |
SE42 | 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Gallbladder | + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 10 |
__________________________________________________________________________|____________|
Liver | + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 10 |
Inflammation, Subacute | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 3 |
Developmental Malformation | | 3 3.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + M + + + M + + | 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 10 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + | 50 |
Follicular Cell, Hyperplasia | 3 3 4 4 4 1 | 15 2.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 10 |
__________________________________________________________________________|____________|
Prostate | + + | 10 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 10 |
__________________________________________________________________________|____________|
Testes | + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 118
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 2| 3| 4| 2| 7| 7| 7| 4| 7| 2| 6| 3| 4| 2| 7| 7| 6| | |
DAY ON TEST | 5| 2| 2| 9| 2| 5| 9| 2| 2| 2| 5| 2| 9| 5| 9| 5| 9| 2| 2| 6| | |
| 8| 9| 9| 5| 0| 8| 1| 9| 9| 9| 8| 9| 5| 2| 5| 8| 2| 9| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| | L |
SE42 | 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + + + + + + + + + + + + + | 66 |
Hyperplasia, Lymphoid | 3 3 | 7 3.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + | 53 |
Hyperplasia, Lymphoid | 3 4 | 5 3.4|
__________________________________________________________________________|____________|
Spleen | + + | 10 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + | 50 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M M M M M + M M M M | 2 |
__________________________________________________________________________|____________|
Skin | M + + + + + M + + M + + | 46 |
Alopecia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 10 |
Mineralization | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Subacute | 3 | 4 3.3|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + | 70 |
Bronchiectasis | | 2 4.0|
Congestion | | 1 2.0|
Inflammation, Subacute | 4 | 7 2.9|
Inflammation, Suppurative | 2 4 4 3 3 3 4 | 23 3.4|
Mineralization | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 5 2.4|
Mucosa, Pigmentation | 2 2 2 3 2 2 1 3 3 3 2 2 2 | 49 2.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Suppurative | 2 3 2 3 4 2 4 | 39 2.8|
Mucosa, Pigmentation | 1 2 2 1 1 1 1 2 1 2 1 2 2 2 2 | 38 1.6|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + | 70 |
Inflammation, Subacute | 2 3 3 3 | 7 2.7|
Inflammation, Suppurative | 2 | 14 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 119
NTP Experiment-Test: 05114-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/23/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:32:28
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 2| 3| 4| 2| 7| 7| 7| 4| 7| 2| 6| 3| 4| 2| 7| 7| 6| | |
DAY ON TEST | 5| 2| 2| 9| 2| 5| 9| 2| 2| 2| 5| 2| 9| 5| 9| 5| 9| 2| 2| 6| | |
| 8| 9| 9| 5| 0| 8| 1| 9| 9| 9| 8| 9| 5| 2| 5| 8| 2| 9| 9| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.5 PPM | 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| | L |
SE42 | 2| 3| 4| 5| 1| 2| 3| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mucosa, Pigmentation | 2 2 2 1 2 2 2 2 2 1 2 1 2 | 40 1.8|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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