TDMS Study 05114-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/15/94
EXP: 05114 HEXACHLOROCYCLOPENTADIENE (HCCPD) TIME: 07:15:07
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 55607B
CONT: N01ES2800301 CAS: 77-47-4
PATHOLOGIST: E. GIDDENS HAILEY, JAMESR.
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
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REMOVAL DATE RANGE:
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/15/94
EXP: 05114 HEXACHLOROCYCLOPENTADIENE (HCCPD) TIME: 07:15:07
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 55607B
CONT: N01ES2800301 CAS: 77-47-4
PATHOLOGIST: E. GIDDENS HAILEY, JAMESR.
HEXACHLOROCYCLOPENTADIENE (HCCPD)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 90 UNCENSORED DEATHS 14 CENSORED DEATHS 41 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 264 464 554 607 626 627 643 648 649 681 |
| 682 689 711 717 |
| CENSORED DEATHS |
| 37 183 183 183 183 183 183 183 183 183 |
| 183 232 232 232 232 232 232 232 232 232 |
| 232 295 295 295 295 295 295 295 295 295 |
| 295 459 459 459 459 459 459 459 459 459 |
| 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.01 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 15 CENSORED DEATHS 12 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 425 443 451 516 557 570 606 617 682 687 |
| 689 697 711 714 725 |
| CENSORED DEATHS |
| 319 459 459 459 459 459 459 459 459 459 |
| 459 655 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.05 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 8 CENSORED DEATHS 10 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 529 607 607 618 620 699 715 718 |
| CENSORED DEATHS |
| 459 459 459 459 459 459 459 459 459 459 |
| |
==================================================================================
HEXACHLOROCYCLOPENTADIENE (HCCPD)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.2 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 16 CENSORED DEATHS 10 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 393 435 460 481 514 522 542 555 617 642 |
| 664 683 707 715 717 726 |
| CENSORED DEATHS |
| 459 459 459 459 459 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.2 PPMSE33 |
| ---------------------------- |
| |
| TOTAL 80 UNCENSORED DEATHS 14 CENSORED DEATHS 31 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 521 542 545 616 626 626 628 634 641 653 |
| 661 696 717 718 |
| CENSORED DEATHS |
| 220 232 232 232 232 232 232 232 232 232 |
| 232 295 295 295 295 295 295 295 295 295 |
| 295 459 459 459 459 459 459 459 459 459 |
| 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.2 PPMSE65 |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 1 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 255 410 452 499 526 557 618 622 623 647 |
| 653 654 656 671 704 706 |
| CENSORED DEATHS |
| 323 |
| |
==================================================================================
HEXACHLOROCYCLOPENTADIENE (HCCPD)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.5 PPMSE26 |
| ---------------------------- |
| |
| TOTAL 90 UNCENSORED DEATHS 9 CENSORED DEATHS 40 TERMINAL 41 |
| |
| UNCENSORED DEATHS |
| 381 494 505 570 612 675 703 703 725 |
| CENSORED DEATHS |
| 183 183 183 183 183 183 183 183 183 183 |
| 232 232 232 232 232 232 232 232 232 232 |
| 295 295 295 295 295 295 295 295 295 295 |
| 458 458 458 458 458 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5 PPMSE42 |
| ---------------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 17 CENSORED DEATHS 20 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 219 245 247 257 262 274 291 292 320 395 |
| 487 601 626 647 652 661 717 |
| CENSORED DEATHS |
| 295 295 295 295 295 295 295 295 295 295 |
| 458 458 458 458 458 458 458 458 458 458 |
| |
==================================================================================
HEXACHLOROCYCLOPENTADIENE (HCCPD)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 98.6 98.6 98.6 96.5 96.5 94.4 82.1 71.9 |
| | |
| | |
|0.01 PPM | 100.0 100.0 100.0 100.0 98.3 94.9 92.9 88.7 84.6 69.8 |
| | |
| | |
|0.05 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 98.0 90.0 84.0 |
| | |
| | |
|0.2 PPM | 100.0 100.0 100.0 100.0 98.3 92.6 86.6 84.6 78.5 68.5 |
| | |
| | |
|0.2 | 100.0 100.0 100.0 100.0 100.0 100.0 93.9 93.9 77.6 71.4 |
|PPMSE33 | |
| | |
|0.2 | 100.0 100.0 98.0 98.0 96.0 93.9 89.8 87.8 73.5 67.4 |
|PPMSE65 | |
| | |
|0.5 | 100.0 100.0 100.0 100.0 98.3 98.3 94.3 92.3 90.3 82.3 |
|PPMSE26 | |
| | |
|0.5 | 100.0 100.0 92.9 86.9 85.2 85.2 83.0 80.9 72.4 70.3 |
|PPMSE42 | |
| | |
==================================================================================
HEXACHLOROCYCLOPENTADIENE (HCCPD)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.01 PPM 0.05 PPM 0.2 PPM 0.2 0.2 0.5 0.5 |
| PPMSE33 PPMSE65 PPMSE26 PPMSE42 |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 71.9% 69.8% 84.0% 68.5% 71.4% 67.4% 82.3% 70.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.901 P=0.936 P=0.204N P=0.794 P=1.000 P=0.652 P=0.311N P=0.500 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 611.6 606.0 639.1 585.8 630.3 578.3 596.4 423.1 |
|NATURAL DEATHS (C) | (32.0) (27.6) (23.4) (27.9) (16.3) (30.7) (39.4) (44.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 508.9 645.2 672.0 645.8 555.2 672.7 521.5 554.0 |
|(STANDARD ERROR) | (23.9) (15.7) (13.3) (15.3) (22.2) (15.6) (23.6) (23.3) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
HEXACHLOROCYCLOPENTADIENE (HCCPD)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 18 CENSORED DEATHS 11 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 249 396 483 520 584 589 598 620 629 633 |
| 634 657 660 672 687 691 693 716 |
| CENSORED DEATHS |
| 157 458 458 458 458 458 458 458 458 458 |
| 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.01 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 18 CENSORED DEATHS 10 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 340 503 555 558 572 576 577 593 629 633 |
| 646 660 660 668 673 680 688 730 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.05 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 19 CENSORED DEATHS 11 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 74 411 554 554 574 575 592 604 625 635 |
| 643 654 660 674 674 688 706 715 730 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 458 |
| 718 |
| |
==================================================================================
HEXACHLOROCYCLOPENTADIENE (HCCPD)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.2 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 28 CENSORED DEATHS 11 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 400 418 466 496 498 500 516 519 528 546 |
| 554 570 606 610 610 611 614 618 619 621 |
| 673 674 690 695 696 724 730 730 |
| CENSORED DEATHS |
| 22 458 458 458 458 458 458 458 458 458 |
| 458 |
| |
==================================================================================
HEXACHLOROCYCLOPENTADIENE (HCCPD)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 736 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 736 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 98.3 98.3 96.6 94.6 92.5 86.3 74.0 63.7 |
| | |
| | |
|0.01 PPM | 100.0 100.0 100.0 98.3 98.3 98.3 96.3 84.3 74.3 64.2 |
| | |
| | |
|0.05 PPM | 98.3 98.3 98.3 98.3 96.7 96.7 96.7 84.6 74.5 62.4 |
| | |
| | |
|0.2 PPM | 100.0 100.0 100.0 100.0 96.6 94.6 82.2 76.1 59.6 43.2 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.01 PPM 0.05 PPM 0.2 PPM|
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 63.7% 64.2% 62.4% 43.2% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.010 P=1.000N P=1.000 P=0.053 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 595.1 607.8 596.9 590.4 |
|NATURAL DEATHS (C) | (27.9) (20.9) (33.7) (17.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 637.7 651.2 645.3 609.8 |
|(STANDARD ERROR) | (17.8) (14.8) (17.1) (18.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
HEXACHLOROCYCLOPENTADIENE (HCCPD)
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.01 PPM = 2
0.05 PPM = 3
0.2 PPM = 4
0.2 PPMSE33 = 5
0.2 PPMSE65 = 6
0.5 PPMSE26 = 7
0.5 PPMSE42 = 8
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 8 61 7 4 2 53
| 8 8 1 7 4 2 42 1 7
| 886 6 53 5 3
| 88 6 42 241 7 7 1
95 + 24 4 2 1 1
| 88 6 67 5 7 353
P | 8 8 4 6 2 6 2 7 17 1
E | 8 8 4 4 2 2 5 5
R 90 + 6 6 73 7 3
C | 8 8 4 4 2 2 1 1 7 7
E | 6 6 3 3
N | 8 8 4 4 2 25511
T 85 + 8 8 4 2 2
| 55 7 37 3
S | 8 8 4 41 12 7 7
U | 8 68 565
R 80 + 465 4
V | 8 8 4 422
I | 5 115
V | 88 41241
A 75 + 8 8 54 4
L | 6 6 11
| 8 282
| 6 6 1 1
70 + 42 2
| 4 4
| 6 6
|
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 20 obs hidden.
HEXACHLOROCYCLOPENTADIENE (HCCPD)
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.01 PPM = 2
0.05 PPM = 3
0.2 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 2 4
| 3 1 2 1434 4 1 2 2
| 4 1 4 1
| 44 1 2 2 1
P 90 + 221 1
E | 4 4 4 2 113 1
R | 44 2 3 11
C | 4 4 11
E 80 + 4 4 232
N | 4 4 1321 2
T | 4 44 1 113
| 12 1
S 70 + 223
U | 22 3 3
R | 44 1 1 22
V | 1 31
I 60 + 4 4
V |
A | 4 4
L | 44
50 + 4 4
| 4 4
|
| 44
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 42 obs hidden.