TDMS Study 05114-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
HEXACHLOROCYCLOPENTADIENE (HCCPD)
NTP Experiment-Test: 05114-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:26:49
Facility: Battelle Northwest
Chemical CAS #: 77-47-4
Lock Date: 01/09/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:26:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund 19 16 14 16
Dead 3 1 5 4
Survivors
Terminal Sacrifice 28 33 30 30
Wrong Sex 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (18) (19) (60)
Inflammation, Chronic 1 (2%)
Mediastinum, Inflammation, Granulomatous 1 (6%)
Liver (60) (34) (32) (60)
Angiectasis 1 (2%) 1 (3%) 4 (13%) 2 (3%)
Basophilic Focus 10 (17%) 2 (6%) 2 (6%) 3 (5%)
Clear Cell Focus 2 (3%) 4 (12%) 3 (9%) 3 (5%)
Eosinophilic Focus 1 (3%)
Granuloma, Multifocal 7 (12%) 1 (3%) 2 (6%) 6 (10%)
Hepatodiaphragmatic Nodule 10 (17%) 11 (32%) 8 (25%) 12 (20%)
Pigmentation, Hemosiderin 1 (2%)
Vacuolization Cytoplasmic 7 (12%) 5 (15%) 4 (13%) 3 (5%)
Biliary Tract, Cyst 1 (2%)
Biliary Tract, Hyperplasia 1 (2%)
Hepatocyte, Hyperplasia 2 (3%) 2 (6%)
Mesentery (10) (6) (6) (3)
Hemorrhage 1 (10%) 2 (33%) 1 (33%)
Inflammation, Granulomatous 1 (17%) 2 (33%)
Thrombosis 1 (10%)
Fat, Mineralization 1 (10%)
Fat, Necrosis 9 (90%) 6 (100%) 5 (83%) 2 (67%)
Pancreas (60) (17) (19) (60)
Fibrosis 1 (2%)
Acinus, Atrophy 15 (25%) 1 (6%) 3 (16%) 9 (15%)
Artery, Inflammation 1 (6%)
Pharynx (3) (1)
Hyperkeratosis 1 (33%)
Hyperplasia 2 (67%)
Stomach, Forestomach (59) (18) (22) (60)
Acanthosis 7 (12%) 8 (44%) 7 (32%) 8 (13%)
Erosion 3 (17%) 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:26:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hyperkeratosis 3 (5%) 6 (33%) 6 (27%) 4 (7%)
Inflammation, Suppurative 3 (5%) 2 (11%) 1 (5%) 2 (3%)
Ulcer 3 (5%) 3 (17%) 3 (14%) 1 (2%)
Muscularis, Hypoplasia 1 (6%)
Stomach, Glandular (59) (17) (23) (60)
Erosion 1 (2%) 1 (6%) 2 (3%)
Inflammation, Suppurative 3 (5%) 2 (12%) 1 (4%) 2 (3%)
Mineralization 1 (6%)
Muscularis, Hypoplasia 2 (9%)
Tooth (1) (1)
Inflammation, Suppurative 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (17) (19) (60)
Cardiomyopathy 4 (7%) 1 (5%) 4 (7%)
Thrombosis 2 (3%) 1 (5%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (21) (19) (60)
Cytomegaly 8 (13%) 5 (24%) 2 (11%) 7 (12%)
Hemorrhage 1 (5%) 1 (2%)
Hyperplasia 3 (5%)
Necrosis 1 (2%) 1 (5%) 1 (2%)
Adrenal Medulla (57) (19) (20) (59)
Hyperplasia 3 (5%) 3 (16%) 4 (20%) 4 (7%)
Bilateral, Hyperplasia 1 (5%) 3 (5%)
Islets, Pancreatic (60) (18) (19) (59)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (50) (17) (19) (54)
Hyperplasia 1 (2%) 2 (12%) 2 (4%)
Pituitary Gland (60) (39) (38) (60)
Cyst 4 (7%) 9 (23%) 8 (21%) 2 (3%)
Hemorrhage 1 (3%)
Pars Distalis, Hyperplasia 4 (7%) 6 (15%) 4 (11%) 4 (7%)
Pars Intermedia, Hyperplasia 1 (3%)
Thyroid Gland (60) (19) (19) (60)
Ultimobranchial Cyst 2 (11%) 2 (3%)
C-Cell, Hyperplasia 12 (20%) 3 (16%) 1 (5%) 12 (20%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:26:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (59) (22) (27) (60)
Cyst 2 (3%) 3 (14%) 3 (11%) 1 (2%)
Hyperplasia 4 (7%) 1 (5%) 6 (22%) 1 (2%)
Inflammation, Suppurative 3 (5%) 2 (9%) 1 (4%) 3 (5%)
Ovary (60) (18) (24) (59)
Cyst 1 (2%) 1 (6%) 5 (21%) 2 (3%)
Uterus (60) (22) (59) (60)
Dilatation 2 (3%)
Infarct 1 (2%)
Inflammation, Suppurative 1 (2%)
Cervix, Muscularis, Hyperplasia 2 (3%)
Endometrium, Hyperplasia 1 (5%) 3 (5%) 4 (7%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (17) (19) (60)
Hyperplasia, Reticulum Cell 1 (5%)
Myelofibrosis 2 (12%)
Lymph Node (2) (1) (3)
Renal, Hyperplasia, Lymphoid 1 (50%)
Renal, Pigmentation 1 (50%) 1 (33%)
Lymph Node, Bronchial (44) (17) (16) (51)
Hemorrhage 1 (6%)
Lymph Node, Mandibular (58) (18) (18) (59)
Hyperplasia, Lymphoid 3 (5%) 1 (6%) 2 (3%)
Inflammation, Chronic 1 (2%) 2 (11%)
Lymph Node, Mesenteric (59) (17) (18) (59)
Hemorrhage 1 (2%) 1 (6%)
Lymph Node, Mediastinal (57) (18) (18) (54)
Hemorrhage 1 (2%) 1 (6%) 1 (6%)
Pigmentation 1 (6%) 2 (4%)
Spleen (60) (21) (26) (60)
Ectopic Tissue 1 (5%) 2 (8%) 2 (3%)
Fibrosis 4 (7%) 3 (14%) 5 (19%)
Hyperplasia, Reticulum Cell 4 (7%) 1 (4%)
Necrosis 1 (2%) 2 (8%)
Pigmentation, Hemosiderin 1 (2%)
Thymus (57) (17) (16) (55)
Cyst 1 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:26:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (34) (29) (60)
Inflammation, Suppurative 1 (2%)
Skin (60) (17) (19) (60)
Abscess 1 (2%)
Ulcer 1 (6%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (18) (19) (60)
Compression 11 (18%) 6 (33%) 4 (21%) 16 (27%)
Hemorrhage 3 (5%) 2 (11%) 8 (42%) 6 (10%)
Hydrocephalus 4 (7%) 1 (6%) 3 (16%) 10 (17%)
Necrosis 1 (5%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (60) (59) (58) (60)
Foreign Body 3 (5%) 1 (2%) 3 (5%)
Hyperplasia 1 (2%)
Inflammation, Chronic 4 (7%) 2 (3%) 4 (7%) 5 (8%)
Inflammation, Suppurative 5 (8%) 2 (3%) 2 (3%) 4 (7%)
Metaplasia, Squamous 11 (18%) 21 (36%) 15 (26%) 24 (40%)
Lung (60) (60) (59) (60)
Congestion 1 (2%) 3 (5%)
Foreign Body 1 (2%) 1 (2%)
Granuloma 3 (5%) 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (5%) 3 (5%) 2 (3%) 9 (15%)
Alveolus, Hemorrhage 19 (32%) 18 (30%) 22 (37%) 23 (38%)
Alveolus, Infiltration Cellular, Multifocal,
Histiocyte 5 (8%) 7 (12%) 8 (14%) 10 (17%)
Alveolus, Inflammation, Suppurative 1 (2%) 3 (5%)
Artery, Mineralization 1 (2%) 2 (3%) 2 (3%) 1 (2%)
Bronchiole, Pigmentation 26 (43%) 48 (81%) 60 (100%)
Peribronchiolar, Pigmentation 3 (5%) 1 (2%) 5 (8%) 35 (58%)
Pleura, Fibrosis 2 (3%) 1 (2%)
Nose (60) (60) (59) (60)
Foreign Body 3 (5%) 1 (2%) 6 (10%) 7 (12%)
Hemorrhage 4 (7%) 1 (2%) 6 (10%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:26:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Suppurative 5 (8%) 5 (8%) 4 (7%) 12 (20%)
Pigmentation 42 (70%) 57 (97%) 57 (95%)
Nasolacrimal Duct, Hemorrhage 3 (5%) 1 (2%) 2 (3%)
Nasolacrimal Duct, Inflammation, Suppurative 2 (3%) 10 (17%) 9 (15%) 3 (5%)
Respiratory Epithelium, Hyperplasia 4 (7%) 6 (10%) 4 (7%) 12 (20%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 2 (3%) 3 (5%)
Trachea (60) (60) (59) (60)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Pigmentation 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (5) (1) (6) (4)
Cataract 3 (60%) 1 (100%) 2 (33%) 4 (100%)
Anterior Chamber, Inflammation, Suppurative 1 (20%)
Cornea, Inflammation 1 (20%)
Harderian Gland (1) (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (59) (60)
Mineralization 13 (22%) 14 (23%) 13 (22%) 14 (23%)
Nephropathy, Chronic 57 (95%) 59 (98%) 57 (97%) 60 (100%)
Cortex, Renal Tubule, Cytoplasmic Alteration 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (60) (17) (19) (59)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:26:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund 27 30 23 31
Dead 5 4 5 3
Survivors
Terminal Sacrifice 18 16 22 16
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (57) (34) (25) (59)
Mineralization 1 (2%)
Intestine Large, Rectum (57) (34) (24) (60)
Ulcer 1 (2%)
Intestine Large, Cecum (58) (32) (23) (59)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (2%)
Intestine Small, Ileum (56) (32) (24) (58)
Inflammation, Suppurative 1 (3%)
Liver (60) (42) (36) (60)
Angiectasis 1 (2%) 1 (3%)
Basophilic Focus 10 (17%) 3 (7%) 2 (6%) 4 (7%)
Clear Cell Focus 4 (7%) 4 (10%) 3 (8%) 5 (8%)
Eosinophilic Focus 1 (2%)
Granuloma, Multifocal 3 (5%) 2 (3%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 3 (5%) 7 (17%) 1 (3%) 1 (2%)
Hyperplasia 3 (5%)
Infarct 1 (2%)
Necrosis, Focal 1 (2%)
Thrombosis 1 (3%)
Vacuolization Cytoplasmic 1 (2%) 2 (5%) 3 (5%)
Biliary Tract, Hyperplasia 9 (15%) 2 (5%) 1 (3%) 2 (3%)
Hepatocyte, Hyperplasia 1 (2%) 1 (2%) 4 (11%)
Mesentery (12) (11) (8) (14)
Hemorrhage 2 (17%)
Inflammation, Granulomatous 2 (17%) 1 (9%) 2 (14%)
Fat, Mineralization 1 (13%)
Fat, Necrosis 9 (75%) 7 (64%) 7 (88%) 12 (86%)
Pancreas (60) (34) (30) (60)
Fibrosis 2 (3%) 1 (2%)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:26:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Atrophy 29 (48%) 13 (38%) 9 (30%) 22 (37%)
Acinus, Hyperplasia 1 (3%)
Artery, Inflammation 1 (2%) 2 (7%)
Pharynx (3)
Developmental Malformation 1 (33%)
Stomach, Forestomach (60) (36) (30) (60)
Acanthosis 6 (10%) 6 (17%) 6 (20%) 6 (10%)
Edema 1 (3%) 1 (2%)
Erosion 1 (3%)
Hyperkeratosis 3 (5%) 4 (11%) 3 (10%) 1 (2%)
Inflammation, Suppurative 3 (5%) 2 (6%) 1 (3%) 2 (3%)
Mineralization 1 (2%) 2 (7%) 1 (2%)
Ulcer 2 (3%) 3 (8%) 2 (7%) 1 (2%)
Muscularis, Hypoplasia 1 (3%) 1 (3%) 4 (7%)
Stomach, Glandular (60) (35) (30) (60)
Edema 1 (3%) 1 (2%)
Erosion 1 (2%) 2 (6%) 2 (3%)
Hemorrhage 1 (2%)
Inflammation, Suppurative 3 (5%) 2 (6%) 1 (3%) 2 (3%)
Mineralization 1 (2%) 2 (6%) 1 (3%) 1 (2%)
Necrosis 1 (3%)
Serosa, Fibrosis 1 (2%)
Tooth (1) (1) (1)
Inflammation, Suppurative 1 (100%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (5) (3) (2) (2)
Atherosclerosis, Diffuse 1 (20%) 1 (50%)
Mineralization 2 (40%)
Mineralization, Diffuse 1 (33%) 1 (50%)
Polyarteritis, Diffuse 1 (33%) 1 (50%)
Thrombosis 1 (20%)
Aorta, Atherosclerosis 1 (20%)
Aorta, Mineralization 1 (50%)
Mesenteric Artery, Developmental Malformation 1 (33%)
Heart (60) (34) (27) (60)
Cardiomyopathy 17 (28%) 9 (26%) 4 (15%) 19 (32%)
Mineralization 1 (2%) 2 (6%) 1 (4%) 1 (2%)
Thrombosis 1 (2%) 1 (3%) 1 (4%) 3 (5%)
Myocardium, Hemorrhage 1 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:26:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (33) (27) (60)
Cytomegaly 9 (15%) 4 (12%) 4 (15%) 10 (17%)
Hemorrhage 1 (3%)
Hyperplasia 2 (3%) 3 (9%) 1 (4%)
Metaplasia, Osseous 1 (4%)
Necrosis 1 (3%)
Adrenal Medulla (60) (34) (28) (59)
Hyperplasia 10 (17%) 8 (24%) 7 (25%) 13 (22%)
Bilateral, Hyperplasia 3 (5%) 3 (9%) 3 (11%) 6 (10%)
Islets, Pancreatic (60) (34) (29) (60)
Hyperplasia 3 (5%)
Parathyroid Gland (56) (30) (25) (56)
Hyperplasia 2 (4%) 2 (7%) 3 (12%) 4 (7%)
Pituitary Gland (60) (39) (38) (59)
Cyst 1 (3%) 3 (8%) 3 (5%)
Hemorrhage 1 (2%) 2 (5%) 1 (3%) 1 (2%)
Necrosis 1 (2%) 1 (3%)
Pars Distalis, Hyperplasia 10 (17%) 4 (10%) 3 (8%) 6 (10%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (59) (35) (33) (60)
Ultimobranchial Cyst 1 (2%) 2 (6%) 3 (5%)
C-Cell, Hyperplasia 7 (12%) 1 (3%) 8 (13%)
Follicular Cell, Cyst 1 (2%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (35) (27) (60)
Granuloma Sperm 1 (4%)
Preputial Gland (60) (38) (30) (58)
Cyst 7 (12%) 3 (8%) 1 (3%) 4 (7%)
Hyperplasia 1 (2%) 2 (5%)
Inflammation, Suppurative 6 (10%) 2 (5%) 3 (5%)
Prostate (60) (36) (30) (60)
Inflammation, Suppurative 15 (25%) 13 (36%) 14 (47%) 13 (22%)
Epithelium, Hyperplasia 6 (10%) 3 (8%) 1 (3%) 3 (5%)
Seminal Vesicle (60) (35) (29) (60)
Inflammation, Suppurative 11 (18%) 3 (9%) 5 (17%) 5 (8%)
Epithelium, Hyperplasia 2 (7%)
Testes (60) (50) (49) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:26:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Arteriole, Inflammation 4 (7%) 2 (4%) 5 (8%)
Interstitial Cell, Hyperplasia 5 (8%) 12 (24%) 8 (16%) 11 (18%)
Seminiferous Tubule, Atrophy 9 (15%) 8 (16%) 10 (20%) 12 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (34) (27) (60)
Hyperplasia, Reticulum Cell 1 (2%)
Myelofibrosis 1 (2%) 2 (6%) 2 (7%) 4 (7%)
Lymph Node (3) (6) (11) (8)
Pancreatic, Hemorrhage 1 (9%)
Renal, Hemorrhage 1 (33%) 1 (9%)
Renal, Hyperplasia, Lymphoid 1 (9%) 1 (13%)
Renal, Pigmentation 1 (9%)
Lymph Node, Bronchial (51) (32) (28) (52)
Hemorrhage 1 (2%) 1 (4%)
Pigmentation 1 (2%) 1 (2%)
Lymph Node, Mandibular (58) (32) (30) (60)
Hemorrhage 1 (3%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (6%) 4 (13%) 3 (5%)
Inflammation, Chronic 1 (2%)
Lymph Node, Mesenteric (59) (35) (31) (60)
Hemorrhage 1 (2%) 1 (3%) 2 (6%) 1 (2%)
Inflammation 1 (2%)
Lymph Node, Mediastinal (58) (32) (28) (58)
Hemorrhage 1 (2%) 1 (3%)
Mineralization 1 (2%)
Pigmentation 2 (3%) 2 (6%) 3 (5%)
Spleen (60) (41) (37) (60)
Ectopic Tissue 1 (2%) 1 (3%) 3 (5%)
Fibrosis 5 (8%) 9 (22%) 9 (24%) 7 (12%)
Hyperplasia, Reticulum Cell 1 (2%)
Necrosis 3 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (34) (27) (60)
Galactocele 1 (3%) 2 (3%)
Hyperplasia 1 (2%) 3 (5%)
Inflammation, Suppurative 3 (5%)
Skin (60) (38) (34) (60)
Abscess 1 (2%) 1 (3%) 1 (2%)
Acanthosis 2 (3%) 3 (8%) 1 (3%)
Cyst Epithelial Inclusion 5 (8%) 2 (5%) 4 (12%) 2 (3%)
Hyperkeratosis 1 (2%) 3 (8%) 1 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:26:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Ulcer 2 (3%) 2 (5%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (59) (34) (27) (60)
Fibrous Osteodystrophy 1 (2%)
Inflammation, Suppurative 1 (4%)
Skeletal Muscle (1) (2) (2)
Mineralization 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (35) (29) (60)
Compression 6 (10%) 5 (14%) 9 (31%) 8 (13%)
Gliosis 1 (2%)
Hemorrhage 6 (10%) 6 (17%) 5 (17%) 6 (10%)
Hemorrhage, Multifocal 1 (3%)
Hydrocephalus 4 (7%) 5 (14%) 10 (34%) 4 (7%)
Mineralization 1 (3%)
Necrosis 1 (2%) 1 (3%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (58) (60) (57) (59)
Foreign Body 1 (2%) 2 (3%)
Hyperplasia 1 (2%)
Inflammation, Chronic 3 (5%) 1 (2%) 1 (2%) 1 (2%)
Inflammation, Suppurative 7 (12%) 4 (7%) 2 (4%) 4 (7%)
Metaplasia, Squamous 1 (2%) 4 (7%) 6 (11%) 4 (7%)
Mineralization 1 (2%) 1 (2%)
Lung (60) (60) (60) (60)
Congestion 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 9 (15%) 6 (10%) 6 (10%) 4 (7%)
Alveolus, Hemorrhage 18 (30%) 23 (38%) 24 (40%) 22 (37%)
Alveolus, Infiltration Cellular, Multifocal,
Histiocyte 10 (17%) 7 (12%) 10 (17%) 15 (25%)
Alveolus, Inflammation, Suppurative 1 (2%) 2 (3%) 1 (2%) 1 (2%)
Artery, Mineralization 2 (3%) 3 (5%) 7 (12%) 2 (3%)
Bronchiole, Pigmentation 1 (2%) 59 (98%)
Peribronchiolar, Pigmentation 2 (3%) 20 (33%)
Pleura, Fibrosis 1 (2%)
Nose (58) (60) (59) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:26:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Foreign Body 2 (3%) 5 (8%) 8 (14%) 7 (12%)
Hemorrhage 7 (12%) 8 (13%) 7 (12%) 9 (15%)
Inflammation, Suppurative 10 (17%) 7 (12%) 6 (10%) 13 (22%)
Pigmentation 1 (2%) 54 (90%) 58 (98%) 55 (92%)
Nasolacrimal Duct, Hemorrhage 6 (10%) 1 (2%) 7 (12%) 6 (10%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%) 1 (2%) 2 (3%) 2 (3%)
Respiratory Epithelium, Hyperplasia 8 (14%) 11 (18%) 9 (15%) 15 (25%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 2 (3%) 2 (3%)
Trachea (58) (60) (58) (60)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Pigmentation 5 (8%)
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SPECIAL SENSES SYSTEM
Eye (4) (4) (7) (7)
Atrophy 1 (25%)
Cataract 2 (50%) 2 (50%) 5 (71%) 2 (29%)
Anterior Chamber, Hemorrhage 1 (14%)
Anterior Chamber, Inflammation, Suppurative 1 (25%) 1 (25%)
Choroid, Iris, Inflammation, Chronic 2 (50%) 1 (14%)
Cornea, Inflammation 1 (25%) 1 (14%)
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URINARY SYSTEM
Kidney (60) (38) (36) (60)
Cyst 1 (2%) 2 (6%) 1 (2%)
Mineralization 1 (2%) 3 (8%) 1 (3%) 2 (3%)
Nephropathy, Chronic 56 (93%) 37 (97%) 33 (92%) 59 (98%)
Cortex, Necrosis 1 (2%)
Papilla, Necrosis 1 (3%)
Pelvis, Dilatation 2 (5%) 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%)
Renal Tubule, Hyperplasia 2 (3%)
Urethra (1)
Inflammation, Suppurative 1 (100%)
Urinary Bladder (60) (34) (27) (60)
Inflammation, Suppurative 1 (2%) 1 (3%) 3 (11%) 1 (2%)
Transitional Epithelium, Hyperplasia 2 (3%) 1 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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