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https://ntp.niehs.nih.gov/go/3372

TDMS Study 05114-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)


NTP Experiment-Test: 05114-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:49




       Facility:  Battelle Northwest

       Chemical CAS #:  77-47-4

       Lock Date:  01/09/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05114-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          19           16           14           16                                     
    Dead                                               3            1            5            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           33           30           30                                     
  Wrong Sex                                                                      1                                                  
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (18)         (19)         (60)                                   
      Inflammation, Chronic                                                                   1 (2%)                                
      Mediastinum, Inflammation, Granulomatous                      1 (6%)                                                          
   Liver                                              (60)         (34)         (32)         (60)                                   
      Angiectasis                                      1 (2%)       1 (3%)       4 (13%)      2 (3%)                                
      Basophilic Focus                                10 (17%)      2 (6%)       2 (6%)       3 (5%)                                
      Clear Cell Focus                                 2 (3%)       4 (12%)      3 (9%)       3 (5%)                                
      Eosinophilic Focus                                            1 (3%)                                                          
      Granuloma, Multifocal                            7 (12%)      1 (3%)       2 (6%)       6 (10%)                               
      Hepatodiaphragmatic Nodule                      10 (17%)     11 (32%)      8 (25%)     12 (20%)                               
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Vacuolization Cytoplasmic                        7 (12%)      5 (15%)      4 (13%)      3 (5%)                                
      Biliary Tract, Cyst                              1 (2%)                                                                       
      Biliary Tract, Hyperplasia                       1 (2%)                                                                       
      Hepatocyte, Hyperplasia                          2 (3%)                    2 (6%)                                             
   Mesentery                                          (10)         (6)          (6)          (3)                                    
      Hemorrhage                                       1 (10%)                   2 (33%)      1 (33%)                               
      Inflammation, Granulomatous                                   1 (17%)      2 (33%)                                            
      Thrombosis                                       1 (10%)                                                                      
      Fat, Mineralization                              1 (10%)                                                                      
      Fat, Necrosis                                    9 (90%)      6 (100%)     5 (83%)      2 (67%)                               
   Pancreas                                           (60)         (17)         (19)         (60)                                   
      Fibrosis                                                                                1 (2%)                                
      Acinus, Atrophy                                 15 (25%)      1 (6%)       3 (16%)      9 (15%)                               
      Artery, Inflammation                                          1 (6%)                                                          
   Pharynx                                            (3)                       (1)                                                 
      Hyperkeratosis                                   1 (33%)                                                                      
      Hyperplasia                                      2 (67%)                                                                      
   Stomach, Forestomach                               (59)         (18)         (22)         (60)                                   
      Acanthosis                                       7 (12%)      8 (44%)      7 (32%)      8 (13%)                               
      Erosion                                                       3 (17%)                   3 (5%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05114-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperkeratosis                                   3 (5%)       6 (33%)      6 (27%)      4 (7%)                                
      Inflammation, Suppurative                        3 (5%)       2 (11%)      1 (5%)       2 (3%)                                
      Ulcer                                            3 (5%)       3 (17%)      3 (14%)      1 (2%)                                
      Muscularis, Hypoplasia                                        1 (6%)                                                          
   Stomach, Glandular                                 (59)         (17)         (23)         (60)                                   
      Erosion                                          1 (2%)       1 (6%)                    2 (3%)                                
      Inflammation, Suppurative                        3 (5%)       2 (12%)      1 (4%)       2 (3%)                                
      Mineralization                                                1 (6%)                                                          
      Muscularis, Hypoplasia                                                     2 (9%)                                             
   Tooth                                                                        (1)          (1)                                    
      Inflammation, Suppurative                                                  1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (17)         (19)         (60)                                   
      Cardiomyopathy                                   4 (7%)                    1 (5%)       4 (7%)                                
      Thrombosis                                       2 (3%)                    1 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (21)         (19)         (60)                                   
      Cytomegaly                                       8 (13%)      5 (24%)      2 (11%)      7 (12%)                               
      Hemorrhage                                                    1 (5%)                    1 (2%)                                
      Hyperplasia                                                                             3 (5%)                                
      Necrosis                                         1 (2%)       1 (5%)                    1 (2%)                                
   Adrenal Medulla                                    (57)         (19)         (20)         (59)                                   
      Hyperplasia                                      3 (5%)       3 (16%)      4 (20%)      4 (7%)                                
      Bilateral, Hyperplasia                                                     1 (5%)       3 (5%)                                
   Islets, Pancreatic                                 (60)         (18)         (19)         (59)                                   
      Hyperplasia                                      1 (2%)                                 1 (2%)                                
   Parathyroid Gland                                  (50)         (17)         (19)         (54)                                   
      Hyperplasia                                      1 (2%)       2 (12%)                   2 (4%)                                
   Pituitary Gland                                    (60)         (39)         (38)         (60)                                   
      Cyst                                             4 (7%)       9 (23%)      8 (21%)      2 (3%)                                
      Hemorrhage                                                                 1 (3%)                                             
      Pars Distalis, Hyperplasia                       4 (7%)       6 (15%)      4 (11%)      4 (7%)                                
      Pars Intermedia, Hyperplasia                                  1 (3%)                                                          
   Thyroid Gland                                      (60)         (19)         (19)         (60)                                   
      Ultimobranchial Cyst                                          2 (11%)                   2 (3%)                                
      C-Cell, Hyperplasia                             12 (20%)      3 (16%)      1 (5%)      12 (20%)                               
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05114-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (59)         (22)         (27)         (60)                                   
      Cyst                                             2 (3%)       3 (14%)      3 (11%)      1 (2%)                                
      Hyperplasia                                      4 (7%)       1 (5%)       6 (22%)      1 (2%)                                
      Inflammation, Suppurative                        3 (5%)       2 (9%)       1 (4%)       3 (5%)                                
   Ovary                                              (60)         (18)         (24)         (59)                                   
      Cyst                                             1 (2%)       1 (6%)       5 (21%)      2 (3%)                                
   Uterus                                             (60)         (22)         (59)         (60)                                   
      Dilatation                                                                 2 (3%)                                             
      Infarct                                                                    1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
      Cervix, Muscularis, Hyperplasia                                                         2 (3%)                                
      Endometrium, Hyperplasia                                      1 (5%)       3 (5%)       4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (17)         (19)         (60)                                   
      Hyperplasia, Reticulum Cell                                                1 (5%)                                             
      Myelofibrosis                                                 2 (12%)                                                         
   Lymph Node                                                      (2)          (1)          (3)                                    
      Renal, Hyperplasia, Lymphoid                                  1 (50%)                                                         
      Renal, Pigmentation                                           1 (50%)                   1 (33%)                               
   Lymph Node, Bronchial                              (44)         (17)         (16)         (51)                                   
      Hemorrhage                                                                 1 (6%)                                             
   Lymph Node, Mandibular                             (58)         (18)         (18)         (59)                                   
      Hyperplasia, Lymphoid                            3 (5%)                    1 (6%)       2 (3%)                                
      Inflammation, Chronic                            1 (2%)                    2 (11%)                                            
   Lymph Node, Mesenteric                             (59)         (17)         (18)         (59)                                   
      Hemorrhage                                       1 (2%)                    1 (6%)                                             
   Lymph Node, Mediastinal                            (57)         (18)         (18)         (54)                                   
      Hemorrhage                                       1 (2%)       1 (6%)       1 (6%)                                             
      Pigmentation                                                               1 (6%)       2 (4%)                                
   Spleen                                             (60)         (21)         (26)         (60)                                   
      Ectopic Tissue                                                1 (5%)       2 (8%)       2 (3%)                                
      Fibrosis                                         4 (7%)       3 (14%)      5 (19%)                                            
      Hyperplasia, Reticulum Cell                      4 (7%)                    1 (4%)                                             
      Necrosis                                         1 (2%)                    2 (8%)                                             
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
   Thymus                                             (57)         (17)         (16)         (55)                                   
      Cyst                                                          1 (6%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05114-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (34)         (29)         (60)                                   
      Inflammation, Suppurative                                                               1 (2%)                                
   Skin                                               (60)         (17)         (19)         (60)                                   
      Abscess                                                                                 1 (2%)                                
      Ulcer                                                         1 (6%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (18)         (19)         (60)                                   
      Compression                                     11 (18%)      6 (33%)      4 (21%)     16 (27%)                               
      Hemorrhage                                       3 (5%)       2 (11%)      8 (42%)      6 (10%)                               
      Hydrocephalus                                    4 (7%)       1 (6%)       3 (16%)     10 (17%)                               
      Necrosis                                                                   1 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (60)         (59)         (58)         (60)                                   
      Foreign Body                                     3 (5%)       1 (2%)       3 (5%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic                            4 (7%)       2 (3%)       4 (7%)       5 (8%)                                
      Inflammation, Suppurative                        5 (8%)       2 (3%)       2 (3%)       4 (7%)                                
      Metaplasia, Squamous                            11 (18%)     21 (36%)     15 (26%)     24 (40%)                               
   Lung                                               (60)         (60)         (59)         (60)                                   
      Congestion                                                                 1 (2%)       3 (5%)                                
      Foreign Body                                     1 (2%)                                 1 (2%)                                
      Granuloma                                        3 (5%)                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 3 (5%)       3 (5%)       2 (3%)       9 (15%)                               
      Alveolus, Hemorrhage                            19 (32%)     18 (30%)     22 (37%)     23 (38%)                               
      Alveolus, Infiltration Cellular, Multifocal,                                                                                  
           Histiocyte                                  5 (8%)       7 (12%)      8 (14%)     10 (17%)                               
      Alveolus, Inflammation, Suppurative              1 (2%)                                 3 (5%)                                
      Artery, Mineralization                           1 (2%)       2 (3%)       2 (3%)       1 (2%)                                
      Bronchiole, Pigmentation                                     26 (43%)     48 (81%)     60 (100%)                              
      Peribronchiolar, Pigmentation                    3 (5%)       1 (2%)       5 (8%)      35 (58%)                               
      Pleura, Fibrosis                                                           2 (3%)       1 (2%)                                
   Nose                                               (60)         (60)         (59)         (60)                                   
      Foreign Body                                     3 (5%)       1 (2%)       6 (10%)      7 (12%)                               
      Hemorrhage                                       4 (7%)       1 (2%)       6 (10%)      1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05114-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Suppurative                        5 (8%)       5 (8%)       4 (7%)      12 (20%)                               
      Pigmentation                                                 42 (70%)     57 (97%)     57 (95%)                               
      Nasolacrimal Duct, Hemorrhage                    3 (5%)                    1 (2%)       2 (3%)                                
      Nasolacrimal Duct, Inflammation, Suppurative     2 (3%)      10 (17%)      9 (15%)      3 (5%)                                
      Respiratory Epithelium, Hyperplasia              4 (7%)       6 (10%)      4 (7%)      12 (20%)                               
      Respiratory Epithelium, Metaplasia, Squamous     1 (2%)                    2 (3%)       3 (5%)                                
   Trachea                                            (60)         (60)         (59)         (60)                                   
      Inflammation, Chronic                                         1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Suppurative                        1 (2%)                                                                       
      Pigmentation                                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (5)          (1)          (6)          (4)                                    
      Cataract                                         3 (60%)      1 (100%)     2 (33%)      4 (100%)                              
      Anterior Chamber, Inflammation, Suppurative      1 (20%)                                                                      
      Cornea, Inflammation                             1 (20%)                                                                      
   Harderian Gland                                    (1)          (1)                                                              
      Inflammation, Suppurative                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (59)         (60)                                   
      Mineralization                                  13 (22%)     14 (23%)     13 (22%)     14 (23%)                               
      Nephropathy, Chronic                            57 (95%)     59 (98%)     57 (97%)     60 (100%)                              
      Cortex, Renal Tubule, Cytoplasmic Alteration                               1 (2%)                                             
      Pelvis, Transitional Epithelium, Hyperplasia     1 (2%)                                                                       
   Urinary Bladder                                    (60)         (17)         (19)         (59)                                   
      Transitional Epithelium, Hyperplasia             1 (2%)                                 1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05114-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          27           30           23           31                                     
    Dead                                               5            4            5            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                18           16           22           16                                     
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (57)         (34)         (25)         (59)                                   
      Mineralization                                                                          1 (2%)                                
   Intestine Large, Rectum                            (57)         (34)         (24)         (60)                                   
      Ulcer                                                                                   1 (2%)                                
   Intestine Large, Cecum                             (58)         (32)         (23)         (59)                                   
      Inflammation, Suppurative                        1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
   Intestine Small, Ileum                             (56)         (32)         (24)         (58)                                   
      Inflammation, Suppurative                                     1 (3%)                                                          
   Liver                                              (60)         (42)         (36)         (60)                                   
      Angiectasis                                      1 (2%)                    1 (3%)                                             
      Basophilic Focus                                10 (17%)      3 (7%)       2 (6%)       4 (7%)                                
      Clear Cell Focus                                 4 (7%)       4 (10%)      3 (8%)       5 (8%)                                
      Eosinophilic Focus                                            1 (2%)                                                          
      Granuloma, Multifocal                            3 (5%)                                 2 (3%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       3 (5%)       7 (17%)      1 (3%)       1 (2%)                                
      Hyperplasia                                                                             3 (5%)                                
      Infarct                                          1 (2%)                                                                       
      Necrosis, Focal                                               1 (2%)                                                          
      Thrombosis                                                                 1 (3%)                                             
      Vacuolization Cytoplasmic                        1 (2%)       2 (5%)                    3 (5%)                                
      Biliary Tract, Hyperplasia                       9 (15%)      2 (5%)       1 (3%)       2 (3%)                                
      Hepatocyte, Hyperplasia                          1 (2%)       1 (2%)       4 (11%)                                            
   Mesentery                                          (12)         (11)         (8)          (14)                                   
      Hemorrhage                                       2 (17%)                                                                      
      Inflammation, Granulomatous                      2 (17%)      1 (9%)                    2 (14%)                               
      Fat, Mineralization                                                        1 (13%)                                            
      Fat, Necrosis                                    9 (75%)      7 (64%)      7 (88%)     12 (86%)                               
   Pancreas                                           (60)         (34)         (30)         (60)                                   
      Fibrosis                                         2 (3%)                                 1 (2%)                                
      Inflammation, Chronic                            1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05114-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acinus, Atrophy                                 29 (48%)     13 (38%)      9 (30%)     22 (37%)                               
      Acinus, Hyperplasia                                                        1 (3%)                                             
      Artery, Inflammation                             1 (2%)                    2 (7%)                                             
   Pharynx                                                                      (3)                                                 
      Developmental Malformation                                                 1 (33%)                                            
   Stomach, Forestomach                               (60)         (36)         (30)         (60)                                   
      Acanthosis                                       6 (10%)      6 (17%)      6 (20%)      6 (10%)                               
      Edema                                                                      1 (3%)       1 (2%)                                
      Erosion                                                                    1 (3%)                                             
      Hyperkeratosis                                   3 (5%)       4 (11%)      3 (10%)      1 (2%)                                
      Inflammation, Suppurative                        3 (5%)       2 (6%)       1 (3%)       2 (3%)                                
      Mineralization                                   1 (2%)                    2 (7%)       1 (2%)                                
      Ulcer                                            2 (3%)       3 (8%)       2 (7%)       1 (2%)                                
      Muscularis, Hypoplasia                                        1 (3%)       1 (3%)       4 (7%)                                
   Stomach, Glandular                                 (60)         (35)         (30)         (60)                                   
      Edema                                                                      1 (3%)       1 (2%)                                
      Erosion                                          1 (2%)       2 (6%)                    2 (3%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Suppurative                        3 (5%)       2 (6%)       1 (3%)       2 (3%)                                
      Mineralization                                   1 (2%)       2 (6%)       1 (3%)       1 (2%)                                
      Necrosis                                                      1 (3%)                                                          
      Serosa, Fibrosis                                                                        1 (2%)                                
   Tooth                                              (1)          (1)                       (1)                                    
      Inflammation, Suppurative                        1 (100%)     1 (100%)                  1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (5)          (3)          (2)          (2)                                    
      Atherosclerosis, Diffuse                         1 (20%)                                1 (50%)                               
      Mineralization                                   2 (40%)                                                                      
      Mineralization, Diffuse                                       1 (33%)                   1 (50%)                               
      Polyarteritis, Diffuse                                        1 (33%)      1 (50%)                                            
      Thrombosis                                       1 (20%)                                                                      
      Aorta, Atherosclerosis                           1 (20%)                                                                      
      Aorta, Mineralization                                                      1 (50%)                                            
      Mesenteric Artery, Developmental Malformation                 1 (33%)                                                         
   Heart                                              (60)         (34)         (27)         (60)                                   
      Cardiomyopathy                                  17 (28%)      9 (26%)      4 (15%)     19 (32%)                               
      Mineralization                                   1 (2%)       2 (6%)       1 (4%)       1 (2%)                                
      Thrombosis                                       1 (2%)       1 (3%)       1 (4%)       3 (5%)                                
      Myocardium, Hemorrhage                                        1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05114-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (33)         (27)         (60)                                   
      Cytomegaly                                       9 (15%)      4 (12%)      4 (15%)     10 (17%)                               
      Hemorrhage                                                    1 (3%)                                                          
      Hyperplasia                                      2 (3%)       3 (9%)       1 (4%)                                             
      Metaplasia, Osseous                                                        1 (4%)                                             
      Necrosis                                                      1 (3%)                                                          
   Adrenal Medulla                                    (60)         (34)         (28)         (59)                                   
      Hyperplasia                                     10 (17%)      8 (24%)      7 (25%)     13 (22%)                               
      Bilateral, Hyperplasia                           3 (5%)       3 (9%)       3 (11%)      6 (10%)                               
   Islets, Pancreatic                                 (60)         (34)         (29)         (60)                                   
      Hyperplasia                                      3 (5%)                                                                       
   Parathyroid Gland                                  (56)         (30)         (25)         (56)                                   
      Hyperplasia                                      2 (4%)       2 (7%)       3 (12%)      4 (7%)                                
   Pituitary Gland                                    (60)         (39)         (38)         (59)                                   
      Cyst                                                          1 (3%)       3 (8%)       3 (5%)                                
      Hemorrhage                                       1 (2%)       2 (5%)       1 (3%)       1 (2%)                                
      Necrosis                                         1 (2%)                    1 (3%)                                             
      Pars Distalis, Hyperplasia                      10 (17%)      4 (10%)      3 (8%)       6 (10%)                               
      Pars Intermedia, Hyperplasia                                                            1 (2%)                                
   Thyroid Gland                                      (59)         (35)         (33)         (60)                                   
      Ultimobranchial Cyst                             1 (2%)       2 (6%)                    3 (5%)                                
      C-Cell, Hyperplasia                              7 (12%)      1 (3%)                    8 (13%)                               
      Follicular Cell, Cyst                            1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (35)         (27)         (60)                                   
      Granuloma Sperm                                                            1 (4%)                                             
   Preputial Gland                                    (60)         (38)         (30)         (58)                                   
      Cyst                                             7 (12%)      3 (8%)       1 (3%)       4 (7%)                                
      Hyperplasia                                      1 (2%)       2 (5%)                                                          
      Inflammation, Suppurative                        6 (10%)      2 (5%)                    3 (5%)                                
   Prostate                                           (60)         (36)         (30)         (60)                                   
      Inflammation, Suppurative                       15 (25%)     13 (36%)     14 (47%)     13 (22%)                               
      Epithelium, Hyperplasia                          6 (10%)      3 (8%)       1 (3%)       3 (5%)                                
   Seminal Vesicle                                    (60)         (35)         (29)         (60)                                   
      Inflammation, Suppurative                       11 (18%)      3 (9%)       5 (17%)      5 (8%)                                
      Epithelium, Hyperplasia                                                    2 (7%)                                             
   Testes                                             (60)         (50)         (49)         (60)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05114-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Arteriole, Inflammation                          4 (7%)                    2 (4%)       5 (8%)                                
      Interstitial Cell, Hyperplasia                   5 (8%)      12 (24%)      8 (16%)     11 (18%)                               
      Seminiferous Tubule, Atrophy                     9 (15%)      8 (16%)     10 (20%)     12 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (34)         (27)         (60)                                   
      Hyperplasia, Reticulum Cell                      1 (2%)                                                                       
      Myelofibrosis                                    1 (2%)       2 (6%)       2 (7%)       4 (7%)                                
   Lymph Node                                         (3)          (6)          (11)         (8)                                    
      Pancreatic, Hemorrhage                                                     1 (9%)                                             
      Renal, Hemorrhage                                1 (33%)                   1 (9%)                                             
      Renal, Hyperplasia, Lymphoid                                               1 (9%)       1 (13%)                               
      Renal, Pigmentation                                                        1 (9%)                                             
   Lymph Node, Bronchial                              (51)         (32)         (28)         (52)                                   
      Hemorrhage                                       1 (2%)                    1 (4%)                                             
      Pigmentation                                     1 (2%)                                 1 (2%)                                
   Lymph Node, Mandibular                             (58)         (32)         (30)         (60)                                   
      Hemorrhage                                                    1 (3%)                    1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)       2 (6%)       4 (13%)      3 (5%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
   Lymph Node, Mesenteric                             (59)         (35)         (31)         (60)                                   
      Hemorrhage                                       1 (2%)       1 (3%)       2 (6%)       1 (2%)                                
      Inflammation                                     1 (2%)                                                                       
   Lymph Node, Mediastinal                            (58)         (32)         (28)         (58)                                   
      Hemorrhage                                       1 (2%)       1 (3%)                                                          
      Mineralization                                   1 (2%)                                                                       
      Pigmentation                                     2 (3%)       2 (6%)                    3 (5%)                                
   Spleen                                             (60)         (41)         (37)         (60)                                   
      Ectopic Tissue                                   1 (2%)                    1 (3%)       3 (5%)                                
      Fibrosis                                         5 (8%)       9 (22%)      9 (24%)      7 (12%)                               
      Hyperplasia, Reticulum Cell                      1 (2%)                                                                       
      Necrosis                                         3 (5%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (34)         (27)         (60)                                   
      Galactocele                                                   1 (3%)                    2 (3%)                                
      Hyperplasia                                      1 (2%)                                 3 (5%)                                
      Inflammation, Suppurative                                                               3 (5%)                                
   Skin                                               (60)         (38)         (34)         (60)                                   
      Abscess                                          1 (2%)       1 (3%)                    1 (2%)                                
      Acanthosis                                       2 (3%)       3 (8%)       1 (3%)                                             
      Cyst Epithelial Inclusion                        5 (8%)       2 (5%)       4 (12%)      2 (3%)                                
      Hyperkeratosis                                   1 (2%)       3 (8%)       1 (3%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05114-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Ulcer                                            2 (3%)       2 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (59)         (34)         (27)         (60)                                   
      Fibrous Osteodystrophy                           1 (2%)                                                                       
      Inflammation, Suppurative                                                  1 (4%)                                             
   Skeletal Muscle                                    (1)                       (2)          (2)                                    
      Mineralization                                                                          1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (35)         (29)         (60)                                   
      Compression                                      6 (10%)      5 (14%)      9 (31%)      8 (13%)                               
      Gliosis                                          1 (2%)                                                                       
      Hemorrhage                                       6 (10%)      6 (17%)      5 (17%)      6 (10%)                               
      Hemorrhage, Multifocal                                        1 (3%)                                                          
      Hydrocephalus                                    4 (7%)       5 (14%)     10 (34%)      4 (7%)                                
      Mineralization                                                             1 (3%)                                             
      Necrosis                                         1 (2%)                    1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (58)         (60)         (57)         (59)                                   
      Foreign Body                                     1 (2%)       2 (3%)                                                          
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic                            3 (5%)       1 (2%)       1 (2%)       1 (2%)                                
      Inflammation, Suppurative                        7 (12%)      4 (7%)       2 (4%)       4 (7%)                                
      Metaplasia, Squamous                             1 (2%)       4 (7%)       6 (11%)      4 (7%)                                
      Mineralization                                   1 (2%)                    1 (2%)                                             
   Lung                                               (60)         (60)         (60)         (60)                                   
      Congestion                                                    1 (2%)       1 (2%)                                             
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Thrombosis                                                                 1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 9 (15%)      6 (10%)      6 (10%)      4 (7%)                                
      Alveolus, Hemorrhage                            18 (30%)     23 (38%)     24 (40%)     22 (37%)                               
      Alveolus, Infiltration Cellular, Multifocal,                                                                                  
           Histiocyte                                 10 (17%)      7 (12%)     10 (17%)     15 (25%)                               
      Alveolus, Inflammation, Suppurative              1 (2%)       2 (3%)       1 (2%)       1 (2%)                                
      Artery, Mineralization                           2 (3%)       3 (5%)       7 (12%)      2 (3%)                                
      Bronchiole, Pigmentation                                                   1 (2%)      59 (98%)                               
      Peribronchiolar, Pigmentation                                              2 (3%)      20 (33%)                               
      Pleura, Fibrosis                                                                        1 (2%)                                
   Nose                                               (58)         (60)         (59)         (60)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05114-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:26:49  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Foreign Body                                     2 (3%)       5 (8%)       8 (14%)      7 (12%)                               
      Hemorrhage                                       7 (12%)      8 (13%)      7 (12%)      9 (15%)                               
      Inflammation, Suppurative                       10 (17%)      7 (12%)      6 (10%)     13 (22%)                               
      Pigmentation                                     1 (2%)      54 (90%)     58 (98%)     55 (92%)                               
      Nasolacrimal Duct, Hemorrhage                    6 (10%)      1 (2%)       7 (12%)      6 (10%)                               
      Nasolacrimal Duct, Inflammation, Suppurative     1 (2%)       1 (2%)       2 (3%)       2 (3%)                                
      Respiratory Epithelium, Hyperplasia              8 (14%)     11 (18%)      9 (15%)     15 (25%)                               
      Respiratory Epithelium, Metaplasia, Squamous     1 (2%)       2 (3%)                    2 (3%)                                
   Trachea                                            (58)         (60)         (58)         (60)                                   
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Suppurative                                     1 (2%)                                                          
      Pigmentation                                                                            5 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (4)          (7)          (7)                                    
      Atrophy                                          1 (25%)                                                                      
      Cataract                                         2 (50%)      2 (50%)      5 (71%)      2 (29%)                               
      Anterior Chamber, Hemorrhage                                                            1 (14%)                               
      Anterior Chamber, Inflammation, Suppurative      1 (25%)      1 (25%)                                                         
      Choroid, Iris, Inflammation, Chronic             2 (50%)                                1 (14%)                               
      Cornea, Inflammation                             1 (25%)                                1 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (38)         (36)         (60)                                   
      Cyst                                             1 (2%)                    2 (6%)       1 (2%)                                
      Mineralization                                   1 (2%)       3 (8%)       1 (3%)       2 (3%)                                
      Nephropathy, Chronic                            56 (93%)     37 (97%)     33 (92%)     59 (98%)                               
      Cortex, Necrosis                                 1 (2%)                                                                       
      Papilla, Necrosis                                             1 (3%)                                                          
      Pelvis, Dilatation                                            2 (5%)                    1 (2%)                                
      Pelvis, Transitional Epithelium, Hyperplasia                                            1 (2%)                                
      Renal Tubule, Hyperplasia                                                               2 (3%)                                
   Urethra                                                                      (1)                                                 
      Inflammation, Suppurative                                                  1 (100%)                                           
   Urinary Bladder                                    (60)         (34)         (27)         (60)                                   
      Inflammation, Suppurative                        1 (2%)       1 (3%)       3 (11%)      1 (2%)                                
      Transitional Epithelium, Hyperplasia             2 (3%)                    1 (4%)       1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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                             ----------              END OF REPORT             ----------                                           
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