TDMS Study 05114-01 Pathology Tables
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
Facility: Battelle Northwest
Chemical CAS #: 77-47-4
Lock Date: 01/09/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 5| 4| 6| 6| 4|
DAY ON TEST | 3| 8| 3| 3| 3| 8| 5| 3| 5| 5| 3| 0| 3| 3| 2| 5| 3| 5| 6| 5| 0| 5| 7| 2| 5|
| 3| 1| 3| 3| 3| 0| 3| 3| 9| 9| 3| 3| 3| 3| 6| 9| 3| 9| 0| 9| 2| 9| 7| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Mesentery | + + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pharynx | + |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + M + + + M + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 5| 4| 6| 6| 4|
DAY ON TEST | 3| 8| 3| 3| 3| 8| 5| 3| 5| 5| 3| 0| 3| 3| 2| 5| 3| 5| 6| 5| 0| 5| 7| 2| 5|
| 3| 1| 3| 3| 3| 0| 3| 3| 9| 9| 3| 3| 3| 3| 6| 9| 3| 9| 0| 9| 2| 9| 7| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X |
Sarcoma Stromal | X |
Bilateral, Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + M M M + + M + + M M + + M + M + + M|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + M + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X |
Adenocarcinoma, Multiple | |
Fibroadenoma | X X X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 4| 6| 4| 5| 4| 6| 6| 4|
DAY ON TEST | 3| 8| 3| 3| 3| 8| 5| 3| 5| 5| 3| 0| 3| 3| 2| 5| 3| 5| 6| 5| 0| 5| 7| 2| 5|
| 3| 1| 3| 3| 3| 0| 3| 3| 9| 9| 3| 3| 3| 3| 6| 9| 3| 9| 0| 9| 2| 9| 7| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Zymbal's Gland| X |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 3| 7| 6| 6| 7| 7| 4| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 7| 3| 8| 8| 3| 3| 5| 0| 5| 3| 3| 3| 3|
| 8| 3| 3| 3| 3| 3| 9| 5| 6| 3| 3| 9| 6| 3| 1| 3| 3| 3| 9| 9| 9| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pharynx | + + |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + I + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + I + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + M + + + + + + M + + M + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | X X |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + M M + + + + + + + + + + + + M + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X|
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 3| 7| 6| 6| 7| 7| 4| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 7| 3| 8| 8| 3| 3| 5| 0| 5| 3| 3| 3| 3|
| 8| 3| 3| 3| 3| 3| 9| 5| 6| 3| 3| 9| 6| 3| 1| 3| 3| 3| 9| 9| 9| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X |
Sarcoma Stromal | |
Bilateral, Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + M + + + + + + + + M + M + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + M + + + + + + + M|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Adenocarcinoma, Multiple | X |
Fibroadenoma | X X X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Metastatic, Mammary | |
Gland | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 6| 3| 7| 6| 6| 7| 7| 4| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 0| 8| 3| 3| 3| 7| 3| 8| 8| 3| 3| 5| 0| 5| 3| 3| 3| 3|
| 8| 3| 3| 3| 3| 3| 9| 5| 6| 3| 3| 9| 6| 3| 1| 3| 3| 3| 9| 9| 9| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
CONTROL | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar/Bronchiolar Adenoma | |
Carcinoma, Metastatic, Zymbal's Gland| |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 3| 7| 6| | |
DAY ON TEST | 5| 3| 3| 3| 4| 1| 3| 7| 3| 6| | |
| 9| 3| 3| 3| 0| 9| 3| 6| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| | A |
CONTROL | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | X X X X | 16 |
__________________________________________________________________________|____________|
Mesentery | + + | 10 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Carcinoma, Metastatic, Kidney | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pharynx | | 3 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 57 |
Leukemia Mononuclear | X | 4 |
Pheochromocytoma Benign | X X | 5 |
Bilateral, Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Adenoma | X | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | X X X X X X X | 32 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 3| 7| 6| | |
DAY ON TEST | 5| 3| 3| 3| 4| 1| 3| 7| 3| 6| | |
| 9| 3| 3| 3| 0| 9| 3| 6| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| | A |
CONTROL | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Intermedia, Adenoma | | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Adenoma | X | 6 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
Carcinoma | X | 5 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Granulosa Cell Tumor Benign | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Polyp Stromal | | 3 |
Sarcoma Stromal | | 1 |
Bilateral, Polyp Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M + + + + + + | 44 |
Leukemia Mononuclear | X X | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Leukemia Mononuclear | X X | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Leukemia Mononuclear | X X | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + + + + + | 57 |
Leukemia Mononuclear | X X | 8 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X X | 16 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 57 |
Leukemia Mononuclear | X | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Adenocarcinoma | | 2 |
Adenocarcinoma, Multiple | | 1 |
Fibroadenoma | X X X | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 6| 7| 7| 3| 7| 6| | |
DAY ON TEST | 5| 3| 3| 3| 4| 1| 3| 7| 3| 6| | |
| 9| 3| 3| 3| 0| 9| 3| 6| 3| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| | A |
CONTROL | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Adenocarcinoma, Metastatic, Mammary | | |
Gland | | 1 |
Alveolar/Bronchiolar Adenoma | | 1 |
Carcinoma, Metastatic, Zymbal's Gland| | 1 |
Leukemia Mononuclear | X X | 11 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 5 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Carcinoma | | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X X | 16 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 4| 7| 6| 4| 7| 7| 7| 7| 5| 7| 6| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 5| 3| 9| 5| 3| 3| 3| 3| 2| 3| 8| 5| 3| 5| 5| 3| 5| 3| 3| 3| 3| 8| 5| 5| 3|
| 9| 2| 4| 9| 2| 2| 2| 2| 1| 2| 3| 9| 2| 9| 9| 2| 9| 2| 2| 2| 2| 1| 9| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Mesentery | + + + |
__________________________________________________________________________|
Pancreas | + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + |
__________________________________________________________________________|
Tongue | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + |
Carcinoma | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + |
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + |
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X |
Pars Intermedia, Adenoma | X |
Pars Nervosa, Hamartoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 4| 7| 6| 4| 7| 7| 7| 7| 5| 7| 6| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 5| 3| 9| 5| 3| 3| 3| 3| 2| 3| 8| 5| 3| 5| 5| 3| 5| 3| 3| 3| 3| 8| 5| 5| 3|
| 9| 2| 4| 9| 2| 2| 2| 2| 1| 2| 3| 9| 2| 9| 9| 2| 9| 2| 2| 2| 2| 1| 9| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + |
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + |
Polyp Stromal | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Thymus | + + + + + + |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + +|
Adenoacanthoma | |
Adenocarcinoma | X |
Fibroadenoma | X X X X X |
Fibroadenoma, Multiple | X X X X X|
__________________________________________________________________________|
Skin | + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Carcinoma, Metastatic, Adrenal Cortex| |
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 4| 7| 6| 4| 7| 7| 7| 7| 5| 7| 6| 4| 7| 4| 4| 7| 4| 7| 7| 7| 7| 6| 6| 6| 7|
DAY ON TEST | 5| 3| 9| 5| 3| 3| 3| 3| 2| 3| 8| 5| 3| 5| 5| 3| 5| 3| 3| 3| 3| 8| 5| 5| 3|
| 9| 2| 4| 9| 2| 2| 2| 2| 1| 2| 3| 9| 2| 9| 9| 2| 9| 2| 2| 2| 2| 1| 9| 4| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + |
Duct, Carcinoma | X |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 0| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 6| 3| 3| 3| 5| 3| 3| 2| 3| 3|
| 8| 4| 5| 9| 2| 2| 8| 2| 2| 2| 2| 2| 9| 9| 2| 5| 2| 2| 2| 9| 2| 2| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01 PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + |
__________________________________________________________________________|
Tongue | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + |
Carcinoma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + M + + + + |
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + |
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X |
Pars Intermedia, Adenoma | |
Pars Nervosa, Hamartoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 0| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 6| 3| 3| 3| 5| 3| 3| 2| 3| 3|
| 8| 4| 5| 9| 2| 2| 8| 2| 2| 2| 2| 2| 9| 9| 2| 5| 2| 2| 2| 9| 2| 2| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01 PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + |
Carcinoma | X X X |
__________________________________________________________________________|
Ovary | + + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + |
Polyp Stromal | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + +|
Adenoacanthoma | X |
Adenocarcinoma | |
Fibroadenoma | X X X X X X X|
Fibroadenoma, Multiple | |
__________________________________________________________________________|
Skin | + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
Carcinoma, Metastatic, Adrenal Cortex| X |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 6| 6| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 4| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 5| 0| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 0| 3| 6| 3| 3| 3| 5| 3| 3| 2| 3| 3|
| 8| 4| 5| 9| 2| 2| 8| 2| 2| 2| 2| 2| 9| 9| 2| 5| 2| 2| 2| 9| 2| 2| 1| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.01 PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Duct, Carcinoma | |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 9| 3| 2| 2| 2| 3| 5| 3| | |
| 2| 2| 1| 2| 4| 5| 4| 2| 9| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | A |
0.01 PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 18 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 17 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 17 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 34 |
Hepatocellular Adenoma | | 2 |
Leukemia Mononuclear | X X X X | 14 |
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 17 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 17 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 18 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 17 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 17 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 21 |
Carcinoma | | 1 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 19 |
Leukemia Mononuclear | | 4 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 18 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 17 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 39 |
Leukemia Mononuclear | X X | 3 |
Pars Distalis, Adenoma | X X X X X X | 30 |
Pars Intermedia, Adenoma | | 1 |
Pars Nervosa, Hamartoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 9| 3| 2| 2| 2| 3| 5| 3| | |
| 2| 2| 1| 2| 4| 5| 4| 2| 9| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | A |
0.01 PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 19 |
C-Cell, Adenoma | | 3 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + | 22 |
Carcinoma | X X | 5 |
__________________________________________________________________________|____________|
Ovary | + + + + | 18 |
__________________________________________________________________________|____________|
Uterus | + + + + | 22 |
Polyp Stromal | | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 17 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + | 2 |
Renal, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + | 17 |
Leukemia Mononuclear | X X | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 18 |
Leukemia Mononuclear | X X | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 17 |
Leukemia Mononuclear | X X | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + | 18 |
Leukemia Mononuclear | X X | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + | 21 |
Leukemia Mononuclear | X X X | 13 |
__________________________________________________________________________|____________|
Thymus | + + + + | 17 |
Leukemia Mononuclear | X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 34 |
Adenoacanthoma | | 1 |
Adenocarcinoma | | 1 |
Fibroadenoma | X X | 14 |
Fibroadenoma, Multiple | X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 9| 3| 2| 2| 2| 3| 5| 3| | |
| 2| 2| 1| 2| 4| 5| 4| 2| 9| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| | A |
0.01 PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + | 17 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 17 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 18 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Carcinoma, Metastatic, Adrenal Cortex| | 1 |
Leukemia Mononuclear | X X | 11 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Duct, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 17 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X X | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 4| 6| 3| 4| 7| 4| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7|
DAY ON TEST | 5| 5| 6| 5| 3| 5| 3| 1| 5| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 3| 5| 9| 1| 5| 3|
| 9| 2| 7| 9| 1| 9| 1| 1| 0| 1| 9| 1| 9| 1| 1| 2| 1| 1| 1| 1| 9| 0| 8| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.05 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + A + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + |
Hepatocellular Carcinoma | X |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + |
__________________________________________________________________________|
Pharynx | + |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + +|
__________________________________________________________________________|
Tongue | + |
Squamous Cell Carcinoma, Metastatic, | |
Pharynx | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + |
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + |
C-Cell, Adenoma | |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 4| 6| 3| 4| 7| 4| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7|
DAY ON TEST | 5| 5| 6| 5| 3| 5| 3| 1| 5| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 3| 5| 9| 1| 5| 3|
| 9| 2| 7| 9| 1| 9| 1| 1| 0| 1| 9| 1| 9| 1| 1| 2| 1| 1| 1| 1| 9| 0| 8| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.05 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + |
Carcinoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + |
__________________________________________________________________________|
Lymph Node | |
Pancreatic, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + + + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Thymus | + M + + + + + + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + |
Adenocarcinoma | X X |
Fibroadenoma | X X X X X X |
Fibroadenoma, Multiple | X |
__________________________________________________________________________|
Skin | + + + + + + + + + |
Neurofibrosarcoma | X |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + |
Mandible, Squamous Cell Carcinoma, | |
Metastatic, Pharynx | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 4| 6| 3| 4| 7| 4| 7| 6| 5| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 4| 7|
DAY ON TEST | 5| 5| 6| 5| 3| 5| 3| 1| 5| 3| 6| 3| 0| 3| 3| 4| 3| 3| 3| 3| 5| 9| 1| 5| 3|
| 9| 2| 7| 9| 1| 9| 1| 1| 0| 1| 9| 1| 9| 1| 1| 2| 1| 1| 1| 1| 9| 0| 8| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.05 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + I + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X X X X X X |
Pheochromocytoma Malignant, | |
Metastatic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + + + |
Lids, Fibroma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 4| 7| 7| 5| 0| 7| 7| 5| 4| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 9| 3| 3| 3| 8| 3| 5| 3| 9| 3| 0| 3| 3| 9| 3| 3| 3| 6| 5| 3| 3| 5| 3| 5| 3|
| 5| 1| 1| 1| 5| 1| 9| 1| 5| 1| 2| 1| 1| 7| 7| 1| 1| 2| 9| 1| 1| 9| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.05 PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + |
__________________________________________________________________________|
Pharynx | |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Salivary Glands | + M + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + +|
__________________________________________________________________________|
Tongue | |
Squamous Cell Carcinoma, Metastatic, | |
Pharynx | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + |
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 4| 7| 7| 5| 0| 7| 7| 5| 4| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 9| 3| 3| 3| 8| 3| 5| 3| 9| 3| 0| 3| 3| 9| 3| 3| 3| 6| 5| 3| 3| 5| 3| 5| 3|
| 5| 1| 1| 1| 5| 1| 9| 1| 5| 1| 2| 1| 1| 7| 7| 1| 1| 2| 9| 1| 1| 9| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.05 PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + |
Carcinoma | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X X |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + |
__________________________________________________________________________|
Lymph Node | + |
Pancreatic, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + M + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Thymus | M M + + + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + |
Adenocarcinoma | |
Fibroadenoma | X X X |
Fibroadenoma, Multiple | |
__________________________________________________________________________|
Skin | + + + + + M + |
Neurofibrosarcoma | |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + |
Mandible, Squamous Cell Carcinoma, | |
Metastatic, Pharynx | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 5| 7| 4| 7| 6| 7| 4| 7| 7| 5| 0| 7| 7| 5| 4| 7| 7| 4| 7| 4| 7|
DAY ON TEST | 9| 3| 3| 3| 8| 3| 5| 3| 9| 3| 0| 3| 3| 9| 3| 3| 3| 6| 5| 3| 3| 5| 3| 5| 3|
| 5| 1| 1| 1| 5| 1| 9| 1| 5| 1| 2| 1| 1| 7| 7| 1| 1| 2| 9| 1| 1| 9| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
0.05 PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X X X |
Pheochromocytoma Malignant, | |
Metastatic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Lids, Fibroma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 3| 6| 5| 7| | |
DAY ON TEST | 4| 3| 3| 3| 3| 5| 6| 1| 6| 3| | |
| 9| 1| 1| 1| 1| 9| 6| 8| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| | A |
0.05 PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 19 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A | 18 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A | 18 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A A | 15 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A | 18 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A A | 16 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A A | 16 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 32 |
Hepatocellular Carcinoma | | 1 |
Leukemia Mononuclear | X X X | 16 |
__________________________________________________________________________|____________|
Mesentery | + + | 6 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 19 |
__________________________________________________________________________|____________|
Pharynx | | 1 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 18 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 22 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 23 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Pharynx | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 19 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Leukemia Mononuclear | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 19 |
Leukemia Mononuclear | X X X | 6 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 20 |
Leukemia Mononuclear | X X X | 6 |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 19 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 19 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 38 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 3| 6| 5| 7| | |
DAY ON TEST | 4| 3| 3| 3| 3| 5| 6| 1| 6| 3| | |
| 9| 1| 1| 1| 1| 9| 6| 8| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| | A |
0.05 PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Adenoma | X X X | 25 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 19 |
C-Cell, Adenoma | | 1 |
C-Cell, Carcinoma | X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 27 |
Carcinoma | | 3 |
__________________________________________________________________________|____________|
Ovary | + + + + + | 24 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Polyp Stromal | | 5 |
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 19 |
__________________________________________________________________________|____________|
Lymph Node | | 1 |
Pancreatic, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + | 16 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 18 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 18 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + | 18 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Spleen | + + + + | 26 |
Leukemia Mononuclear | X X X | 16 |
__________________________________________________________________________|____________|
Thymus | + + + + | 16 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Leukemia Mononuclear | X | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 29 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 4| 3| 6| 5| 7| | |
DAY ON TEST | 4| 3| 3| 3| 3| 5| 6| 1| 6| 3| | |
| 9| 1| 1| 1| 1| 9| 6| 8| 1| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| | A |
0.05 PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Adenocarcinoma | X X | 4 |
Fibroadenoma | X X X X | 13 |
Fibroadenoma, Multiple | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + | 19 |
Neurofibrosarcoma | | 1 |
Squamous Cell Papilloma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 19 |
Mandible, Squamous Cell Carcinoma, | | |
Metastatic, Pharynx | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 19 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | X X | 15 |
Pheochromocytoma Malignant, | | |
Metastatic | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 6 |
Lids, Fibroma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 19 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 59 |
Leukemia Mononuclear | X X X | 18 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 4| 7| 4| 7| 6| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 6| 3| 5| 1| 5| 2| 3| 5| 2| 1|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 8| 0| 9| 0| 9| 4| 5| 8| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2_PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma, Multiple | X |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pheochromocytoma Benign | X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + M + M + M + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X X X X X X X|
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 4| 7| 4| 7| 6| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 6| 3| 5| 1| 5| 2| 3| 5| 2| 1|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 8| 0| 9| 0| 9| 4| 5| 8| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2_PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | |
Thecoma Malignant | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Polyp Stromal | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + |
Axillary, Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | M + + + + + + + + + + + + + + + + M + M + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M + + + M + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Fibroadenoma | X X X X X |
Fibroadenoma, Multiple | X |
Sarcoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | X |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 4| 7| 4| 7| 6| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 6| 3| 5| 1| 5| 2| 3| 5| 2| 1|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 0| 0| 8| 0| 9| 0| 9| 4| 5| 8| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2_PPM | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 4| 5| 7| 6| 7| 4| 4| 6| 4| 7| 7| 7| 4| 6| 5| 4| 7| 7| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 3| 5| 6| 3| 2| 3| 5| 5| 9| 5| 1| 3| 3| 5| 6| 4| 5| 3| 3| 2| 6| 3| 2| 3| 3|
| 0| 9| 9| 0| 6| 0| 9| 9| 6| 9| 0| 0| 0| 9| 7| 1| 9| 0| 0| 6| 7| 0| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2_PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma, Multiple | |
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X X X X|
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X|
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 4| 5| 7| 6| 7| 4| 4| 6| 4| 7| 7| 7| 4| 6| 5| 4| 7| 7| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 3| 5| 6| 3| 2| 3| 5| 5| 9| 5| 1| 3| 3| 5| 6| 4| 5| 3| 3| 2| 6| 3| 2| 3| 3|
| 0| 9| 9| 0| 6| 0| 9| 9| 6| 9| 0| 0| 0| 9| 7| 1| 9| 0| 0| 6| 7| 0| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2_PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | |
Thecoma Malignant | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Polyp Stromal | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | |
Axillary, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M M + + + M + M + + M + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Fibroadenoma | X X |
Fibroadenoma, Multiple | X X |
Sarcoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 4| 5| 7| 6| 7| 4| 4| 6| 4| 7| 7| 7| 4| 6| 5| 4| 7| 7| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 3| 5| 6| 3| 2| 3| 5| 5| 9| 5| 1| 3| 3| 5| 6| 4| 5| 3| 3| 2| 6| 3| 2| 3| 3|
| 0| 9| 9| 0| 6| 0| 9| 9| 6| 9| 0| 0| 0| 9| 7| 1| 9| 0| 0| 6| 7| 0| 8| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.2_PPM | 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 5| 7| 7| 5| 4| | |
DAY ON TEST | 5| 3| 3| 2| 3| 8| 3| 3| 9| 5| | |
| 9| 0| 0| 8| 0| 8| 0| 0| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
0.2_PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hepatocellular Adenoma, Multiple | | 1 |
Leukemia Mononuclear | X X X | 21 |
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Leukemia Mononuclear | X | 3 |
Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
Pars Distalis, Adenoma | X X X X X X | 40 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Adenoma | | 5 |
C-Cell, Carcinoma | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 5| 7| 7| 5| 4| | |
DAY ON TEST | 5| 3| 3| 2| 3| 8| 3| 3| 9| 5| | |
| 9| 0| 0| 8| 0| 8| 0| 0| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
0.2_PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Carcinoma | | 4 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Granulosa Cell Tumor Benign | X | 1 |
Thecoma Malignant | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Adenocarcinoma | | 1 |
Polyp Stromal | X | 8 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Axillary, Leukemia Mononuclear | | 1 |
Iliac, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | X | 1 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + + + + | 51 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M + M + + + | 54 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X | 21 |
__________________________________________________________________________|____________|
Thymus | + + M + M + M + + + | 55 |
Leukemia Mononuclear | X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Adenocarcinoma | | 1 |
Fibroadenoma | X | 8 |
Fibroadenoma, Multiple | X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 5| 7| 7| 5| 4| | |
DAY ON TEST | 5| 3| 3| 2| 3| 8| 3| 3| 9| 5| | |
| 9| 0| 0| 8| 0| 8| 0| 0| 7| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
0.2_PPM | 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Basal Cell Carcinoma | | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 60 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | X X | 9 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X | 21 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 4| 7| 5| 4| 7| 3| 4| 4| 6| 6| 7| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 6| 3| 3| 2| 3| 5| 9| 2| 5| 3| 4| 5| 3| 7| 5| 5| 3| 2| 3| 3| 3| 3| 1|
| 3| 3| 1| 3| 3| 8| 3| 8| 8| 4| 8| 3| 8| 8| 3| 3| 8| 8| 3| 5| 3| 5| 6| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + I + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Mucinous | X |
Fibroma | |
Peyer's Patch, Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X X |
Pheochromocytoma Benign, Multiple | X |
Bilateral, Pheochromocytoma Benign | X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + M + + + + + + + M + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 4| 7| 5| 4| 7| 3| 4| 4| 6| 6| 7| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 6| 3| 3| 2| 3| 5| 9| 2| 5| 3| 4| 5| 3| 7| 5| 5| 3| 2| 3| 3| 3| 3| 1|
| 3| 3| 1| 3| 3| 8| 3| 8| 8| 4| 8| 3| 8| 8| 3| 3| 8| 8| 3| 5| 3| 5| 6| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X X |
Interstitial Cell, Adenoma, Multiple | X X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | +|
Deep Cervical, Leukemia Mononuclear | X|
Iliac, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | X|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M + + M + + M + + M M + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | X X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 6| 7| 4| 6| 7| 4| 7| 5| 4| 7| 3| 4| 4| 6| 6| 7| 6| 5| 7| 7|
DAY ON TEST | 3| 3| 6| 3| 3| 2| 3| 5| 9| 2| 5| 3| 4| 5| 3| 7| 5| 5| 3| 2| 3| 3| 3| 3| 1|
| 3| 3| 1| 3| 3| 8| 3| 8| 8| 4| 8| 3| 8| 8| 3| 3| 8| 8| 3| 5| 3| 5| 6| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X X|
Fibrosarcoma | |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Leukemia | |
Mononuclear | X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Rhabdomyosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X X X X X X X X|
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Medulla | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | + + |
Carcinoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X|
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 5| 6| 6| 6| 4| 6| 5| 4| 7| 6| 5| 5|
DAY ON TEST | 2| 5| 1| 3| 3| 2| 9| 1| 6| 2| 3| 8| 3| 9| 9| 0| 9| 5| 6| 9| 5| 3| 5| 4| 6|
| 6| 8| 2| 3| 3| 9| 1| 2| 5| 4| 3| 1| 3| 7| 1| 0| 4| 8| 0| 7| 8| 3| 1| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + A + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + A + + + + + + + + + + + + A + +|
Adenocarcinoma, Mucinous | |
Fibroma | X |
Peyer's Patch, Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + A + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X |
Pheochromocytoma Benign, Multiple | |
Bilateral, Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 5| 6| 6| 6| 4| 6| 5| 4| 7| 6| 5| 5|
DAY ON TEST | 2| 5| 1| 3| 3| 2| 9| 1| 6| 2| 3| 8| 3| 9| 9| 0| 9| 5| 6| 9| 5| 3| 5| 4| 6|
| 6| 8| 2| 3| 3| 9| 1| 2| 5| 4| 3| 1| 3| 7| 1| 0| 4| 8| 0| 7| 8| 3| 1| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X X |
Interstitial Cell, Adenoma, Multiple | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node | + |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + M + + + +|
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + M + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 5| 6| 6| 6| 4| 6| 5| 4| 7| 6| 5| 5|
DAY ON TEST | 2| 5| 1| 3| 3| 2| 9| 1| 6| 2| 3| 8| 3| 9| 9| 0| 9| 5| 6| 9| 5| 3| 5| 4| 6|
| 6| 8| 2| 3| 3| 9| 1| 2| 5| 4| 3| 1| 3| 7| 1| 0| 4| 8| 0| 7| 8| 3| 1| 4| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Fibrosarcoma | X |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Leukemia | |
Mononuclear | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Rhabdomyosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + A + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Leukemia Mononuclear | X X X X X X X X X X|
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Medulla | X |
__________________________________________________________________________|
Nose | + + + + + + A + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + A + + A + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Papilloma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 6| 7| 4| 6| 7| 4| | |
DAY ON TEST | 3| 5| 5| 3| 1| 3| 6| 8| 3| 8| | |
| 3| 8| 8| 3| 7| 3| 4| 3| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A | 56 |
Adenocarcinoma, Mucinous | | 1 |
Fibroma | | 1 |
Peyer's Patch, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A | 56 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | X X X X | 29 |
__________________________________________________________________________|____________|
Mesentery | + + + | 12 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 5 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Adenoma | | 1 |
Leukemia Mononuclear | | 9 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 9 |
Pheochromocytoma Malignant | X | 2 |
Pheochromocytoma Benign | X X | 12 |
Pheochromocytoma Benign, Multiple | | 1 |
Bilateral, Pheochromocytoma Benign | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 6| 7| 4| 6| 7| 4| | |
DAY ON TEST | 3| 5| 5| 3| 1| 3| 6| 8| 3| 8| | |
| 3| 8| 8| 3| 7| 3| 4| 3| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Adenoma | X X | 8 |
Carcinoma | | 4 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 3 |
Pars Distalis, Adenoma | X X X X X X | 27 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
C-Cell, Adenoma | X X | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Bilateral, Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Carcinoma | X X | 6 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Mesothelioma Malignant | | 1 |
Bilateral, Interstitial Cell, Adenoma| X X X X | 23 |
Interstitial Cell, Adenoma | X X | 14 |
Interstitial Cell, Adenoma, Multiple | X | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Deep Cervical, Leukemia Mononuclear | | 1 |
Iliac, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + + M + + + + | 51 |
Leukemia Mononuclear | X X | 18 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Leukemia Mononuclear | X X | 18 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 6| 7| 4| 6| 7| 4| | |
DAY ON TEST | 3| 5| 5| 3| 1| 3| 6| 8| 3| 8| | |
| 3| 8| 8| 3| 7| 3| 4| 3| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X | 19 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + | 58 |
Leukemia Mononuclear | X X | 18 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X X | 29 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
Leukemia Mononuclear | | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Fibroma | | 2 |
Fibrosarcoma | | 1 |
Squamous Cell Papilloma | X | 1 |
Subcutaneous Tissue, Leukemia | | |
Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Rhabdomyosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | X | 5 |
Leukemia Mononuclear | X X X | 22 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Medulla | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 7| 4| 4| 7| 6| 7| 4| 6| 7| 4| | |
DAY ON TEST | 3| 5| 5| 3| 1| 3| 6| 8| 3| 8| | |
| 3| 8| 8| 3| 7| 3| 4| 3| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X X | 29 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 6| 5| 6| 3| 5| 6| 7| 7| 4| 5| 7| 4| 7| 7| 7| 5| 6| 6| 7| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 8| 7| 7| 4| 3| 0| 2| 5| 2| 3| 5| 3| 3| 3| 4| 3| 3| 3| 8| 0| 2| 6| 5| 5|
| 9| 4| 0| 0| 1| 6| 9| 4| 8| 3| 2| 8| 2| 2| 2| 4| 4| 9| 2| 1| 5| 4| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.01 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + |
Leukemia Mononuclear | |
Mesothelioma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + |
Adenoma | X X |
Carcinoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + M |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + |
Carcinoma, Metastatic, Zymbal's Gland| |
Leukemia Mononuclear | |
Pars Distalis, Adenoma | X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 6| 5| 6| 3| 5| 6| 7| 7| 4| 5| 7| 4| 7| 7| 7| 5| 6| 6| 7| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 8| 7| 7| 4| 3| 0| 2| 5| 2| 3| 5| 3| 3| 3| 4| 3| 3| 3| 8| 0| 2| 6| 5| 5|
| 9| 4| 0| 0| 1| 6| 9| 4| 8| 3| 2| 8| 2| 2| 2| 4| 4| 9| 2| 1| 5| 4| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.01 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + |
Mesothelioma Malignant, Metastatic, | |
Testes | |
Bilateral, Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Mesothelioma Malignant | |
Bilateral, Mesothelioma Malignant | |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X |
Interstitial Cell, Adenoma, Multiple | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + |
Axillary, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 6| 5| 6| 3| 5| 6| 7| 7| 4| 5| 7| 4| 7| 7| 7| 5| 6| 6| 7| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 8| 7| 7| 4| 3| 0| 2| 5| 2| 3| 5| 3| 3| 3| 4| 3| 3| 3| 8| 0| 2| 6| 5| 5|
| 9| 4| 0| 0| 1| 6| 9| 4| 8| 3| 2| 8| 2| 2| 2| 4| 4| 9| 2| 1| 5| 4| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.01 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + |
Fibroma | |
Fibrosarcoma | X |
Squamous Cell Papilloma | X |
Sebaceous Gland, Carcinoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Zymbal's Gland| |
Leukemia Mononuclear | X X X X X X X X X X X X |
Mesothelioma Malignant, Metastatic, | |
Testes | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | |
Duct, Carcinoma | |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
Nephroblastoma | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 6| 5| 6| 3| 5| 6| 7| 7| 4| 5| 7| 4| 7| 7| 7| 5| 6| 6| 7| 6| 7| 7| 6| 4| 4|
DAY ON TEST | 3| 8| 7| 7| 4| 3| 0| 2| 5| 2| 3| 5| 3| 3| 3| 4| 3| 3| 3| 8| 0| 2| 6| 5| 5|
| 9| 4| 0| 0| 1| 6| 9| 4| 8| 3| 2| 8| 2| 2| 2| 4| 4| 9| 2| 1| 5| 4| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.01 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 4| 5| 7| 3| 6| 7| 7| 7| 5| 7| 6| 3| 6| 7| 6| 4| 6| 5| 7| 4| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 4| 3| 7| 0| 3| 1| 3| 6| 3| 0| 5| 3| 3| 9| 5| 2| 9| 3| 5| 3| 3| 6| 4| 1|
| 1| 0| 2| 9| 0| 2| 9| 2| 4| 2| 0| 5| 5| 2| 8| 8| 8| 7| 2| 8| 2| 2| 5| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.01 PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + A + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + |
Leukemia Mononuclear | X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X|
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Zymbal's Gland| X |
Leukemia Mononuclear | X X X|
Pars Distalis, Adenoma | X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 4| 5| 7| 3| 6| 7| 7| 7| 5| 7| 6| 3| 6| 7| 6| 4| 6| 5| 7| 4| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 4| 3| 7| 0| 3| 1| 3| 6| 3| 0| 5| 3| 3| 9| 5| 2| 9| 3| 5| 3| 3| 6| 4| 1|
| 1| 0| 2| 9| 0| 2| 9| 2| 4| 2| 0| 5| 5| 2| 8| 8| 8| 7| 2| 8| 2| 2| 5| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.01 PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Testes | X |
Bilateral, Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Mesothelioma Malignant | |
Bilateral, Mesothelioma Malignant | X X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X|
Interstitial Cell, Adenoma, Multiple | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + |
Axillary, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + + + + + + M +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X|
Mesothelioma Malignant | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 4| 5| 7| 3| 6| 7| 7| 7| 5| 7| 6| 3| 6| 7| 6| 4| 6| 5| 7| 4| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 4| 3| 7| 0| 3| 1| 3| 6| 3| 0| 5| 3| 3| 9| 5| 2| 9| 3| 5| 3| 3| 6| 4| 1|
| 1| 0| 2| 9| 0| 2| 9| 2| 4| 2| 0| 5| 5| 2| 8| 8| 8| 7| 2| 8| 2| 2| 5| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.01 PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + +|
Fibroma | X |
Fibrosarcoma | |
Squamous Cell Papilloma | |
Sebaceous Gland, Carcinoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Zymbal's Gland| X X |
Leukemia Mononuclear | X X X X X X X X X X X X|
Mesothelioma Malignant, Metastatic, | |
Testes | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | + |
Duct, Carcinoma | X |
__________________________________________________________________________|
Zymbal's Gland | + + |
Carcinoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Nephroblastoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 4| 5| 7| 3| 6| 7| 7| 7| 5| 7| 6| 3| 6| 7| 6| 4| 6| 5| 7| 4| 7| 7| 5| 6| 6|
DAY ON TEST | 5| 4| 3| 7| 0| 3| 1| 3| 6| 3| 0| 5| 3| 3| 9| 5| 2| 9| 3| 5| 3| 3| 6| 4| 1|
| 1| 0| 2| 9| 0| 2| 9| 2| 4| 2| 0| 5| 5| 2| 8| 8| 8| 7| 2| 8| 2| 2| 5| 9| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.01 PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Mesothelioma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 4| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 5| 0| 9| 5| 3| 3| 2| 3| 5| 5| | |
| 8| 4| 5| 8| 2| 2| 6| 2| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.01 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 34 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 34 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 34 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 32 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 34 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 33 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 32 |
__________________________________________________________________________|____________|
Liver | + + + + | 42 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | X | 27 |
__________________________________________________________________________|____________|
Mesentery | + + + + + + | 11 |
Leukemia Mononuclear | | 2 |
Mesothelioma Malignant | X X | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + | 34 |
Leukemia Mononuclear | | 4 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 34 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 36 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 35 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 3 |
__________________________________________________________________________|____________|
Heart | + + + | 34 |
Leukemia Mononuclear | | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 33 |
Leukemia Mononuclear | X | 8 |
__________________________________________________________________________|____________|
Adrenal Medulla | M + + | 34 |
Leukemia Mononuclear | X | 8 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | | 7 |
Bilateral, Pheochromocytoma Benign | X | 3 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 34 |
Adenoma | X | 5 |
Carcinoma | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 4| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 5| 0| 9| 5| 3| 3| 2| 3| 5| 5| | |
| 8| 4| 5| 8| 2| 2| 6| 2| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.01 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + | 30 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 39 |
Carcinoma, Metastatic, Zymbal's Gland| | 1 |
Leukemia Mononuclear | | 3 |
Pars Distalis, Adenoma | X X X | 23 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 35 |
C-Cell, Adenoma | X | 3 |
C-Cell, Carcinoma | | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + | 35 |
Mesothelioma Malignant, Metastatic, | | |
Testes | | 1 |
Bilateral, Mesothelioma Malignant | X X | 3 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 38 |
Carcinoma | | 2 |
__________________________________________________________________________|____________|
Prostate | + + + | 36 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 35 |
__________________________________________________________________________|____________|
Testes | + + + + + + + | 50 |
Leukemia Mononuclear | | 1 |
Mesothelioma Malignant | X | 1 |
Bilateral, Mesothelioma Malignant | X X | 4 |
Bilateral, Interstitial Cell, Adenoma| X X X X X | 21 |
Interstitial Cell, Adenoma | X | 13 |
Interstitial Cell, Adenoma, Multiple | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 34 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Lymph Node | + | 6 |
Axillary, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | X | 6 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + | 32 |
Leukemia Mononuclear | X X | 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 4| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 5| 0| 9| 5| 3| 3| 2| 3| 5| 5| | |
| 8| 4| 5| 8| 2| 2| 6| 2| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.01 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M | 32 |
Leukemia Mononuclear | X X | 15 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 35 |
Leukemia Mononuclear | X X X | 16 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M | 32 |
Leukemia Mononuclear | X X | 15 |
__________________________________________________________________________|____________|
Spleen | + + + + | 41 |
Leukemia Mononuclear | X X X | 31 |
Mesothelioma Malignant | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + M | 32 |
Leukemia Mononuclear | X | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 34 |
__________________________________________________________________________|____________|
Skin | + + + | 38 |
Fibroma | | 1 |
Fibrosarcoma | | 1 |
Squamous Cell Papilloma | | 1 |
Sebaceous Gland, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 34 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 35 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | | 2 |
Carcinoma, Metastatic, Zymbal's Gland| | 2 |
Leukemia Mononuclear | X X X | 27 |
Mesothelioma Malignant, Metastatic, | | |
Testes | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 4| 7| 7| 7| 7| 4| 4| | |
DAY ON TEST | 5| 0| 9| 5| 3| 3| 2| 3| 5| 5| | |
| 8| 4| 5| 8| 2| 2| 6| 2| 8| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.01 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Duct, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 38 |
Leukemia Mononuclear | | 6 |
Nephroblastoma | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 34 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X X | 33 |
Mesothelioma Malignant | X X X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 6| 5| 7| 5| 7| 2| 7| 4| 5| 4| 4| 4| 4|
DAY ON TEST | 5| 6| 2| 0| 3| 3| 1| 3| 3| 0| 5| 5| 6| 9| 3| 0| 3| 3| 2| 5| 1| 5| 5| 5| 5|
| 8| 4| 3| 9| 1| 1| 0| 1| 1| 6| 8| 8| 6| 7| 1| 6| 1| 3| 4| 8| 6| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.05 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + I + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Cecum | A + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Pharynx | + |
Papilloma | |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + |
Carcinoma | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
Bilateral, Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 6| 5| 7| 5| 7| 2| 7| 4| 5| 4| 4| 4| 4|
DAY ON TEST | 5| 6| 2| 0| 3| 3| 1| 3| 3| 0| 5| 5| 6| 9| 3| 0| 3| 3| 2| 5| 1| 5| 5| 5| 5|
| 8| 4| 3| 9| 1| 1| 0| 1| 1| 6| 8| 8| 6| 7| 1| 6| 1| 3| 4| 8| 6| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.05 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + I + + + + + + |
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + |
Bilateral, Interstitial Cell, Adenoma| X X X X X X |
Interstitial Cell, Adenoma | X X X X |
Interstitial Cell, Adenoma, Multiple | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | + + + + |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + |
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 6| 5| 7| 5| 7| 2| 7| 4| 5| 4| 4| 4| 4|
DAY ON TEST | 5| 6| 2| 0| 3| 3| 1| 3| 3| 0| 5| 5| 6| 9| 3| 0| 3| 3| 2| 5| 1| 5| 5| 5| 5|
| 8| 4| 3| 9| 1| 1| 0| 1| 1| 6| 8| 8| 6| 7| 1| 6| 1| 3| 4| 8| 6| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.05 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + |
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + |
Fibroma | X |
Neurofibrosarcoma | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | + + |
Leukemia Mononuclear | X |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + |
Granular Cell Tumor Malignant | |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + A + + + + + I + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Thyroid Gland | |
Hemangiosarcoma, Metastatic, | |
Uncertain Primary Site | X |
Leukemia Mononuclear | X X X X X X X X X X X |
Sarcoma, Metastatic, Skeletal Muscle | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Urethra | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 7| 7| 7| 7| 7| 5| 4| 4| 6| 5| 7| 5| 7| 2| 7| 4| 5| 4| 4| 4| 4|
DAY ON TEST | 5| 6| 2| 0| 3| 3| 1| 3| 3| 0| 5| 5| 6| 9| 3| 0| 3| 3| 2| 5| 1| 5| 5| 5| 5|
| 8| 4| 3| 9| 1| 1| 0| 1| 1| 6| 8| 8| 6| 7| 1| 6| 1| 3| 4| 8| 6| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.05 PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 4| 7| 3| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7|
DAY ON TEST | 0| 3| 3| 3| 1| 4| 3| 5| 3| 6| 6| 8| 3| 4| 1| 3| 0| 3| 0| 1| 3| 5| 3| 7| 3|
| 1| 1| 1| 1| 2| 7| 1| 8| 1| 5| 5| 0| 1| 1| 2| 1| 4| 1| 5| 1| 1| 8| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.05 PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + |
__________________________________________________________________________|
Intestine Large, Colon | + + A A + + + + + + + A |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + A A + + + + + + + A |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Cecum | + + A A + + + + + + + A |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + A A + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + A A + + + + + + + A |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + A A + + + + + + + A |
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + A + + + + + + + + + |
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pharynx | + |
Papilloma | X |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Salivary Glands | + + + A + + + + + + + + |
__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
__________________________________________________________________________|
Heart | + + + A + + + + + + + + |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + A + + + + + + + + |
Carcinoma | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + A + + + + + + + + |
Leukemia Mononuclear | X X X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X |
Bilateral, Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 4| 7| 3| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7|
DAY ON TEST | 0| 3| 3| 3| 1| 4| 3| 5| 3| 6| 6| 8| 3| 4| 1| 3| 0| 3| 0| 1| 3| 5| 3| 7| 3|
| 1| 1| 1| 1| 2| 7| 1| 8| 1| 5| 5| 0| 1| 1| 2| 1| 4| 1| 5| 1| 1| 8| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.05 PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Adenoma | X X X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | M + + M + + + + + + + + |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pituitary Gland | + + + + + A + + + + + + + + + + + + |
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X X X |
C-Cell, Carcinoma | X X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + A + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + A + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + A + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + A + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X|
Interstitial Cell, Adenoma, Multiple | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + |
Deep Cervical, Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + A + + + + + + + + + |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + A + + + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + A + + + + + + + + + |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + A + + + + + + + + |
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + A + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 4| 7| 3| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7|
DAY ON TEST | 0| 3| 3| 3| 1| 4| 3| 5| 3| 6| 6| 8| 3| 4| 1| 3| 0| 3| 0| 1| 3| 5| 3| 7| 3|
| 1| 1| 1| 1| 2| 7| 1| 8| 1| 5| 5| 0| 1| 1| 2| 1| 4| 1| 5| 1| 1| 8| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.05 PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + A + + + + + + + + + |
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + A + + + + + + + + |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + |
Fibroma | |
Neurofibrosarcoma | X |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + A + + + + + + + + |
__________________________________________________________________________|
Skeletal Muscle | |
Leukemia Mononuclear | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + A + + + + + + + + + |
Granular Cell Tumor Malignant | X |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Thyroid Gland | X|
Hemangiosarcoma, Metastatic, | |
Uncertain Primary Site | |
Leukemia Mononuclear | X X X X X X |
Sarcoma, Metastatic, Skeletal Muscle | |
__________________________________________________________________________|
Nose | + + + + + + + + + A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + A + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + A + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urethra | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 4| 7| 3| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 4| 7| 4| 7|
DAY ON TEST | 0| 3| 3| 3| 1| 4| 3| 5| 3| 6| 6| 8| 3| 4| 1| 3| 0| 3| 0| 1| 3| 5| 3| 7| 3|
| 1| 1| 1| 1| 2| 7| 1| 8| 1| 5| 5| 0| 1| 1| 2| 1| 4| 1| 5| 1| 1| 8| 1| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
0.05 PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 6| 7| 7| 6| 7| | |
DAY ON TEST | 0| 3| 3| 3| 0| 3| 3| 3| 4| 3| | |
| 2| 1| 1| 5| 5| 5| 1| 1| 9| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.05 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 28 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 25 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 24 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + | 23 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 26 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + | 23 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 24 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 36 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | X X X X | 24 |
__________________________________________________________________________|____________|
Mesentery | + + | 8 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 30 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Pharynx | + | 3 |
Papilloma | | 1 |
Squamous Cell Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 27 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 30 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 30 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
__________________________________________________________________________|____________|
Heart | + + + + + | 27 |
Leukemia Mononuclear | X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 27 |
Carcinoma | | 1 |
Leukemia Mononuclear | X | 8 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 28 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 68
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 6| 7| 7| 6| 7| | |
DAY ON TEST | 0| 3| 3| 3| 0| 3| 3| 3| 4| 3| | |
| 2| 1| 1| 5| 5| 5| 1| 1| 9| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.05 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X | 8 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X | 6 |
Bilateral, Pheochromocytoma Benign | | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 29 |
Adenoma | X | 5 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 25 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 38 |
Leukemia Mononuclear | | 3 |
Pars Distalis, Adenoma | X X X X X | 23 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 33 |
C-Cell, Adenoma | | 5 |
C-Cell, Carcinoma | | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + | 27 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + | 30 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + | 30 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + | 29 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 49 |
Bilateral, Interstitial Cell, Adenoma| X X X X | 19 |
Interstitial Cell, Adenoma | X X X X | 13 |
Interstitial Cell, Adenoma, Multiple | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 27 |
Leukemia Mononuclear | X X | 7 |
__________________________________________________________________________|____________|
Lymph Node | + + | 11 |
Deep Cervical, Leukemia Mononuclear | | 1 |
Iliac, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | X | 2 |
Renal, Leukemia Mononuclear | X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + | 28 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 69
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 6| 7| 7| 6| 7| | |
DAY ON TEST | 0| 3| 3| 3| 0| 3| 3| 3| 4| 3| | |
| 2| 1| 1| 5| 5| 5| 1| 1| 9| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.05 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X | 16 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 30 |
Leukemia Mononuclear | X X X X | 16 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 31 |
Leukemia Mononuclear | X X X X | 17 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 28 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | X X X | 16 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 37 |
Leukemia Mononuclear | X X X X | 25 |
__________________________________________________________________________|____________|
Thymus | + + + + + | 28 |
Leukemia Mononuclear | X X | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 27 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 34 |
Fibroma | X | 2 |
Neurofibrosarcoma | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 27 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
Leukemia Mononuclear | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 29 |
Granular Cell Tumor Malignant | | 1 |
Leukemia Mononuclear | X | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | | 2 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Hemangiosarcoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Leukemia Mononuclear | X X X X | 21 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 70
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 5| 7| 6| 7| 7| 6| 7| | |
DAY ON TEST | 0| 3| 3| 3| 0| 3| 3| 3| 4| 3| | |
| 2| 1| 1| 5| 5| 5| 1| 1| 9| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
0.05 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Sarcoma, Metastatic, Skeletal Muscle | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + | 7 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 36 |
Leukemia Mononuclear | X X X | 8 |
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 27 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X X | 26 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 71
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 4| 5| 7| 4| 6| 5| 5| 5| 7| 1| 4| 4| 7| 5| 6| 4| 7| 6| 7| 6|
DAY ON TEST | 3| 0| 0| 9| 3| 8| 8| 3| 5| 2| 8| 4| 3| 3| 8| 7| 5| 3| 8| 3| 5| 0| 1| 3| 6|
| 0| 0| 0| 5| 0| 5| 5| 0| 8| 8| 2| 2| 4| 0| 0| 4| 8| 0| 9| 9| 8| 9| 2| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.2_PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + + + + + |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Oral Mucosa | |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Mesothelioma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Bilateral, Adenoma | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X |
Bilateral, Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 4| 5| 7| 4| 6| 5| 5| 5| 7| 1| 4| 4| 7| 5| 6| 4| 7| 6| 7| 6|
DAY ON TEST | 3| 0| 0| 9| 3| 8| 8| 3| 5| 2| 8| 4| 3| 3| 8| 7| 5| 3| 8| 3| 5| 0| 1| 3| 6|
| 0| 0| 0| 5| 0| 5| 5| 0| 8| 8| 2| 2| 4| 0| 0| 4| 8| 0| 9| 9| 8| 9| 2| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.2_PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X X |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Mesothelioma Malignant | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Mesothelioma Malignant | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X X X |
Interstitial Cell, Adenoma, Multiple | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + + |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + + + + + + + M + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
Squamous Cell Carcinoma, Metastatic, | |
Skin | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + M + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
Mesothelioma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 4| 5| 7| 4| 6| 5| 5| 5| 7| 1| 4| 4| 7| 5| 6| 4| 7| 6| 7| 6|
DAY ON TEST | 3| 0| 0| 9| 3| 8| 8| 3| 5| 2| 8| 4| 3| 3| 8| 7| 5| 3| 8| 3| 5| 0| 1| 3| 6|
| 0| 0| 0| 5| 0| 5| 5| 0| 8| 8| 2| 2| 4| 0| 0| 4| 8| 0| 9| 9| 8| 9| 2| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.2_PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | |
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Fibroma | X |
Neurofibroma | |
Neurofibrosarcoma | X |
Squamous Cell Carcinoma | X |
Squamous Cell Papilloma | X |
Sebaceous Gland, Carcinoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glioma Malignant | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | M + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X|
Squamous Cell Carcinoma, Metastatic, | |
Skin | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma, Papillary | |
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 7| 5| 6| 6| 7| 4| 5| 7| 4| 6| 5| 5| 5| 7| 1| 4| 4| 7| 5| 6| 4| 7| 6| 7| 6|
DAY ON TEST | 3| 0| 0| 9| 3| 8| 8| 3| 5| 2| 8| 4| 3| 3| 8| 7| 5| 3| 8| 3| 5| 0| 1| 3| 6|
| 0| 0| 0| 5| 0| 5| 5| 0| 8| 8| 2| 2| 4| 0| 0| 4| 8| 0| 9| 9| 8| 9| 2| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
0.2_PPM | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7|
| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 6| 4| 4| 2| 7| 4| 7| 6| 6| 6| 7| 4| 4| 6| 6| 6| 7| 7| 7| 7| 4| 6| 7| 7| 5|
DAY ON TEST | 2| 5| 5| 2| 3| 5| 0| 1| 8| 8| 2| 5| 5| 0| 3| 2| 3| 3| 0| 3| 5| 2| 3| 2| 4|
| 8| 8| 8| 0| 0| 8| 4| 7| 3| 1| 3| 8| 8| 0| 9| 1| 0| 0| 4| 0| 8| 0| 0| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.2_PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X X |
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + + + + |
Mesothelioma Malignant | |
__________________________________________________________________________|
Oral Mucosa | + |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Mesothelioma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
Bilateral, Adenoma | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +|
Leukemia Mononuclear | X X|
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X X X |
Carcinoma | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 6| 4| 4| 2| 7| 4| 7| 6| 6| 6| 7| 4| 4| 6| 6| 6| 7| 7| 7| 7| 4| 6| 7| 7| 5|
DAY ON TEST | 2| 5| 5| 2| 3| 5| 0| 1| 8| 8| 2| 5| 5| 0| 3| 2| 3| 3| 0| 3| 5| 2| 3| 2| 4|
| 8| 8| 8| 0| 0| 8| 4| 7| 3| 1| 3| 8| 8| 0| 9| 1| 0| 0| 4| 0| 8| 0| 0| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.2_PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X |
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Mesothelioma Malignant | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + M + + + + + + + + + + + + + + + M +|
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Mesothelioma Malignant | |
Bilateral, Interstitial Cell, Adenoma| X X X X |
Interstitial Cell, Adenoma | X X X X X X X X X X X X|
Interstitial Cell, Adenoma, Multiple | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
__________________________________________________________________________|
Lymph Node | + + +|
Pancreatic, Leukemia Mononuclear | X X|
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + M M M + + + + + + + + M + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
Squamous Cell Carcinoma, Metastatic, | |
Skin | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
Mesothelioma Malignant | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 6| 4| 4| 2| 7| 4| 7| 6| 6| 6| 7| 4| 4| 6| 6| 6| 7| 7| 7| 7| 4| 6| 7| 7| 5|
DAY ON TEST | 2| 5| 5| 2| 3| 5| 0| 1| 8| 8| 2| 5| 5| 0| 3| 2| 3| 3| 0| 3| 5| 2| 3| 2| 4|
| 8| 8| 8| 0| 0| 8| 4| 7| 3| 1| 3| 8| 8| 0| 9| 1| 0| 0| 4| 0| 8| 0| 0| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.2_PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Thyroid Gland | X |
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Carcinoma | |
Fibroma | X X |
Neurofibroma | X |
Neurofibrosarcoma | |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | |
Sebaceous Gland, Carcinoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glioma Malignant | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X X|
Squamous Cell Carcinoma, Metastatic, | |
Skin | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma, Papillary | |
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + +|
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
_____________________________________________________________________________________________________________________
| 6| 4| 4| 2| 7| 4| 7| 6| 6| 6| 7| 4| 4| 6| 6| 6| 7| 7| 7| 7| 4| 6| 7| 7| 5|
DAY ON TEST | 2| 5| 5| 2| 3| 5| 0| 1| 8| 8| 2| 5| 5| 0| 3| 2| 3| 3| 0| 3| 5| 2| 3| 2| 4|
| 8| 8| 8| 0| 0| 8| 4| 7| 3| 1| 3| 8| 8| 0| 9| 1| 0| 0| 4| 0| 8| 0| 0| 4| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.2_PPM | 7| 7| 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3|
| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 3| 6| 5| 3| 1| 3| 1| 3| | |
| 0| 8| 0| 0| 3| 0| 2| 0| 9| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.2_PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hepatocellular Adenoma | X | 3 |
Leukemia Mononuclear | X X X X | 29 |
__________________________________________________________________________|____________|
Mesentery | + + + | 14 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 5 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 2 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Leukemia Mononuclear | | 4 |
Bilateral, Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Leukemia Mononuclear | | 4 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | X X X X | 14 |
Bilateral, Pheochromocytoma Benign | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 80
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 3| 6| 5| 3| 1| 3| 1| 3| | |
| 0| 8| 0| 0| 3| 0| 2| 0| 9| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.2_PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Adenoma | X X | 11 |
Carcinoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M | 56 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + | 59 |
Leukemia Mononuclear | | 2 |
Pars Distalis, Adenoma | X X X X X X X X | 36 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Adenoma | X | 3 |
C-Cell, Carcinoma | | 3 |
Follicular Cell, Adenoma | X | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Bilateral, Mesothelioma Malignant | X | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 58 |
Carcinoma | X | 2 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Bilateral, Mesothelioma Malignant | X | 2 |
Bilateral, Interstitial Cell, Adenoma| X X X X X X | 19 |
Interstitial Cell, Adenoma | X | 20 |
Interstitial Cell, Adenoma, Multiple | X | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Lymph Node | + | 8 |
Pancreatic, Leukemia Mononuclear | X | 4 |
Renal, Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + M + + + + + | 52 |
Leukemia Mononuclear | X X X X | 23 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X X | 25 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 81
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 3| 6| 5| 3| 1| 3| 1| 3| | |
| 0| 8| 0| 0| 3| 0| 2| 0| 9| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.2_PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Squamous Cell Carcinoma, Metastatic, | | |
Skin | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X X | 23 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + | 58 |
Leukemia Mononuclear | X X X X | 22 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X X | 29 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 59 |
Carcinoma, Metastatic, Thyroid Gland | | 1 |
Leukemia Mononuclear | X | 8 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Basal Cell Carcinoma | X | 1 |
Fibroma | | 3 |
Neurofibroma | | 1 |
Neurofibrosarcoma | | 1 |
Squamous Cell Carcinoma | | 1 |
Squamous Cell Papilloma | | 1 |
Sebaceous Gland, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Glioma Malignant | | 1 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 82
NTP Experiment-Test: 05114-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 04/01/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 16:16:27
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 4| 6| 7| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 3| 6| 5| 3| 1| 3| 1| 3| | |
| 0| 8| 0| 0| 3| 0| 2| 0| 9| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.2_PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| | L |
| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Carcinoma | | 2 |
Leukemia Mononuclear | X X X | 24 |
Squamous Cell Carcinoma, Metastatic, | | |
Skin | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Adenoma, Papillary | X | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | | 7 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Mesothelioma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Leukemia Mononuclear | X X X X | 29 |
Mesothelioma Malignant | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 83
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