TDMS Study 05114-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
HEXACHLOROCYCLOPENTADIENE (HCCPD)
NTP Experiment-Test: 05114-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:27:20
Facility: Battelle Northwest
Chemical CAS #: 77-47-4
Lock Date: 01/09/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:27:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund 19 16 14 16
Dead 3 1 5 4
Survivors
Terminal Sacrifice 28 33 30 30
Wrong Sex 1
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (18) (19) (60)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Liver (60) (34) (32) (60)
Hepatocellular Carcinoma 1 (3%)
Hepatocellular Adenoma 1 (2%) 2 (6%)
Hepatocellular Adenoma, Multiple 1 (2%)
Mesentery (10) (6) (6) (3)
Pancreas (60) (17) (19) (60)
Carcinoma, Metastatic, Kidney 1 (2%)
Pharynx (3) (1)
Squamous Cell Carcinoma 1 (33%) 1 (100%)
Tongue (1) (1) (1)
Carcinoma 1 (100%) 1 (100%)
Squamous Cell Carcinoma, Metastatic, Pharynx 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (17) (19) (60)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (5%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (21) (19) (60)
Carcinoma 1 (5%)
Adrenal Medulla (57) (19) (20) (59)
Pheochromocytoma Malignant 1 (5%) 1 (5%)
Pheochromocytoma Benign 5 (9%) 2 (11%) 3 (15%) 2 (3%)
Page 2
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:27:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (60) (18) (19) (59)
Adenoma 2 (3%) 1 (6%) 1 (2%)
Pituitary Gland (60) (39) (38) (60)
Pars Distalis, Adenoma 32 (53%) 30 (77%) 25 (66%) 40 (67%)
Pars Intermedia, Adenoma 2 (3%) 1 (3%) 1 (2%)
Pars Nervosa, Hamartoma 1 (3%)
Thyroid Gland (60) (19) (19) (60)
C-Cell, Adenoma 6 (10%) 3 (16%) 1 (5%) 5 (8%)
C-Cell, Carcinoma 1 (5%) 3 (16%) 4 (7%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (5%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (59) (22) (27) (60)
Carcinoma 5 (8%) 5 (23%) 3 (11%) 4 (7%)
Ovary (60) (18) (24) (59)
Granulosa Cell Tumor Benign 1 (2%) 1 (2%)
Thecoma Malignant 1 (2%)
Uterus (60) (22) (59) (60)
Adenocarcinoma 1 (2%)
Polyp Stromal 3 (5%) 5 (23%) 5 (8%) 8 (13%)
Sarcoma Stromal 1 (2%)
Bilateral, Polyp Stromal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (17) (19) (60)
Lymph Node (2) (1) (3)
Lymph Node, Bronchial (44) (17) (16) (51)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Lymph Node, Mandibular (58) (18) (18) (59)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Lymph Node, Mesenteric (59) (17) (18) (59)
Lymph Node, Mediastinal (57) (18) (18) (54)
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (6%)
Spleen (60) (21) (26) (60)
Thymus (57) (17) (16) (55)
Page 3
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:27:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Alveolar/Bronchiolar Carcinoma, Metastatic,
Lung 1 (6%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (34) (29) (60)
Adenoacanthoma 1 (3%)
Adenocarcinoma 2 (3%) 1 (3%) 4 (14%) 1 (2%)
Adenocarcinoma, Multiple 1 (2%)
Fibroadenoma 13 (22%) 14 (41%) 13 (45%) 8 (13%)
Fibroadenoma, Multiple 6 (18%) 1 (3%) 5 (8%)
Sarcoma 1 (2%)
Skin (60) (17) (19) (60)
Basal Cell Carcinoma 1 (2%)
Neurofibrosarcoma 1 (5%)
Squamous Cell Papilloma 1 (5%)
Subcutaneous Tissue, Sarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (17) (19) (60)
Mandible, Squamous Cell Carcinoma,
Metastatic, Pharynx 1 (5%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (60) (59) (58) (60)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Lung (60) (60) (59) (60)
Adenocarcinoma, Metastatic, Mammary Gland 1 (2%)
Alveolar/Bronchiolar Adenoma 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%) 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Carcinoma, Metastatic, Adrenal Cortex 1 (2%)
Pheochromocytoma Malignant, Metastatic 1 (2%)
Trachea (60) (60) (59) (60)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:27:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (5) (1) (6) (4)
Lids, Fibroma 1 (17%)
Harderian Gland (1) (1)
Adenoma 1 (100%)
Duct, Carcinoma 1 (100%)
Zymbal's Gland (1) (1)
Carcinoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (59) (60)
Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Leukemia Mononuclear 16 (27%) 14 (23%) 18 (30%) 21 (35%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:27:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 50 44 51
Total Primary Neoplasms 100 93 83 107
Total Animals with Benign Neoplasms 46 44 39 48
Total Benign Neoplasms 70 65 50 72
Total Animals with Malignant Neoplasms 29 26 27 28
Total Malignant Neoplasms 30 28 33 35
Total Animals with Metastatic Neoplasms 3 2 3 1
Total Metastatic Neoplasm 3 2 6 6
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:27:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund 27 30 23 31
Dead 5 4 5 3
Survivors
Terminal Sacrifice 18 16 22 16
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (57) (34) (25) (59)
Intestine Large, Rectum (57) (34) (24) (60)
Sarcoma 1 (2%)
Intestine Large, Cecum (58) (32) (23) (59)
Intestine Small, Duodenum (57) (34) (26) (60)
Intestine Small, Jejunum (56) (33) (23) (58)
Adenocarcinoma, Mucinous 1 (2%)
Fibroma 1 (2%)
Intestine Small, Ileum (56) (32) (24) (58)
Liver (60) (42) (36) (60)
Hepatocellular Adenoma 1 (2%) 1 (2%) 1 (3%) 3 (5%)
Mesentery (12) (11) (8) (14)
Oral Mucosa (1)
Squamous Cell Carcinoma 1 (100%)
Pancreas (60) (34) (30) (60)
Pharynx (3)
Papilloma 1 (33%)
Squamous Cell Carcinoma 1 (33%)
Stomach, Forestomach (60) (36) (30) (60)
Stomach, Glandular (60) (35) (30) (60)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (34) (27) (60)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:27:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (33) (27) (60)
Adenoma 1 (2%)
Carcinoma 1 (4%)
Bilateral, Adenoma 1 (2%)
Adrenal Medulla (60) (34) (28) (59)
Pheochromocytoma Malignant 2 (3%) 1 (3%) 1 (4%) 1 (2%)
Pheochromocytoma Benign 12 (20%) 7 (21%) 6 (21%) 14 (24%)
Pheochromocytoma Benign, Multiple 1 (2%)
Bilateral, Pheochromocytoma Benign 2 (3%) 3 (9%) 5 (18%) 4 (7%)
Islets, Pancreatic (60) (34) (29) (60)
Adenoma 8 (13%) 5 (15%) 5 (17%) 11 (18%)
Carcinoma 4 (7%) 2 (6%) 1 (3%) 2 (3%)
Parathyroid Gland (56) (30) (25) (56)
Pituitary Gland (60) (39) (38) (59)
Carcinoma, Metastatic, Zymbal's Gland 1 (3%)
Pars Distalis, Adenoma 27 (45%) 23 (59%) 23 (61%) 36 (61%)
Thyroid Gland (59) (35) (33) (60)
C-Cell, Adenoma 5 (8%) 3 (9%) 5 (15%) 3 (5%)
C-Cell, Carcinoma 1 (3%) 3 (9%) 3 (5%)
Follicular Cell, Adenoma 1 (3%) 3 (5%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (35) (27) (60)
Preputial Gland (60) (38) (30) (58)
Carcinoma 6 (10%) 2 (5%) 1 (3%) 2 (3%)
Testes (60) (50) (49) (60)
Bilateral, Interstitial Cell, Adenoma 23 (38%) 21 (42%) 19 (39%) 19 (32%)
Interstitial Cell, Adenoma 14 (23%) 13 (26%) 13 (27%) 20 (33%)
Interstitial Cell, Adenoma, Multiple 10 (17%) 2 (4%) 2 (4%) 5 (8%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (34) (27) (60)
Lymph Node (3) (6) (11) (8)
Lymph Node, Bronchial (51) (32) (28) (52)
Lymph Node, Mandibular (58) (32) (30) (60)
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
Lymph Node, Mesenteric (59) (35) (31) (60)
Page 8
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:27:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Lymph Node, Mediastinal (58) (32) (28) (58)
Carcinoma, Metastatic, Thyroid Gland 1 (4%)
Spleen (60) (41) (37) (60)
Thymus (56) (32) (28) (59)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (38) (34) (60)
Basal Cell Carcinoma 1 (2%)
Fibroma 2 (3%) 1 (3%) 2 (6%) 3 (5%)
Fibrosarcoma 1 (2%) 1 (3%)
Neurofibroma 1 (2%)
Neurofibrosarcoma 1 (3%) 1 (2%)
Sarcoma 1 (3%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (3%) 1 (2%)
Sebaceous Gland, Carcinoma 1 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (2) (2)
Rhabdomyosarcoma 1 (100%)
Sarcoma 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (35) (29) (60)
Glioma Malignant 1 (2%)
Granular Cell Tumor Malignant 1 (3%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Alveolar/Bronchiolar Adenoma 5 (8%) 2 (3%) 2 (3%) 3 (5%)
Alveolar/Bronchiolar Carcinoma 2 (3%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 2 (3%)
Hemangiosarcoma, Metastatic, Uncertain
Primary Site 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Sarcoma, Metastatic, Skeletal Muscle 1 (2%)
Page 9
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:27:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Squamous Cell Carcinoma, Metastatic, Skin 1 (2%)
Nose (58) (60) (59) (60)
Adenoma, Papillary 1 (2%)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (2) (2)
Adenoma 1 (50%)
Duct, Carcinoma 1 (100%)
Zymbal's Gland (2) (2) (1) (1)
Carcinoma 2 (100%) 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (38) (36) (60)
Nephroblastoma 1 (3%)
Urinary Bladder (60) (34) (27) (60)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60)
Leukemia Mononuclear 29 (48%) 33 (55%) 26 (43%) 29 (48%)
Mesothelioma Malignant 1 (2%) 5 (8%) 2 (3%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05114-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC HEXACHLOROCYCLOPENTADIENE (HCCPD) Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:27:20
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 0.01 PPM 0.05 PPM 0.2
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 60 51 52 59
Total Primary Neoplasms 161 133 123 178
Total Animals with Benign Neoplasms 56 47 47 57
Total Benign Neoplasms 114 83 84 130
Total Animals with Malignant Neoplasms 36 38 34 34
Total Malignant Neoplasms 47 50 39 48
Total Animals with Metastatic Neoplasms 1 3 4 3
Total Metastatic Neoplasm 1 5 4 4
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
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