TDMS Study 05114-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest HEXACHLOROCYCLOPENTADIENE (HCCPD) DATE: 09/14/94
EXPERIMENT: 05114 TEST: 01 TIME: 13:48:14
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1ES2800301 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 00125
PATHOLOGIST: R. RENNE HAILEY, JAMES R. CAS: 77-47-4
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest HEXACHLOROCYCLOPENTADIENE (HCCPD) DATE: 09/14/94
EXPERIMENT: 05114 TEST: 01 TIME: 13:48:14
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1ES2800301 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 00125
PATHOLOGIST: R. RENNE HAILEY, JAMES R. CAS: 77-47-4
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Larynx
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Northwest HEXACHLOROCYCLOPENTADIENE (HCCPD) DATE: 09/14/94
EXPERIMENT: 05114 TEST: 01 TIME: 13:48:14
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1ES2800301 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 00125
PATHOLOGIST: R. RENNE HAILEY, JAMES R. CAS: 77-47-4
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF HEXACHLOROCYCLOPENTADIENE (HCCPD)
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Lung Alveolar/Bronchiolar Carcinoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Testes Adenoma
Thyroid Gland: C-Cell Carcinoma or Adenoma
Thyroid Gland: Follicular Cell
Adenoma
Carcinoma or Adenoma
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Malignant
Pheochromocytoma: Benign, Complex, Malignant, NOS
Thyroid Gland: C-Cell Carcinoma
====================================================================================================
DATE: 09/15/94 EXPERIMENT: 05114 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.01 PPM 0.05 PPM 0.2 | CONTROL 0.01 PPM 0.05 PPM 0.2 |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/60 (25%) 10/44 (23%) 11/38 (29%) 18/59 (31%) | 6/57 (11%) 2/29 (7%) 3/30 (10%) 2/60 (3%) |
|ADJUSTED (b) | 58.2% 100.0% 100.0% 61.3% | 20.2% 5.1% 7.9% 5.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 8/18 (44%) 1/1 (100%) 1/1 (100%) 6/16 (38%) | 4/26 (15%) 0/2 (0%) 0/1 (0%) 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | 628 565 471 458 (I) | 681 681 562 617 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.268 P=0.291 P=0.329 P=0.250 | P=0.107N P=0.533N P=0.526 P=0.110N |
|INCIDENTAL TUMOR | P=0.250 P=0.224 P=0.140 P=0.186 | P=0.089N P=0.637N P=0.504 P=0.098N |
|LOGISTIC REGRESSION | P=0.323 P=0.218 P=0.078 P=0.206 | P=0.071N P=0.608 P=0.270 P=0.109N |
|COCHRAN-ARMITAGE | P=0.242 | P=0.113N |
|FISHER EXACT | P=0.488N P=0.419 P=0.321 | P=0.453N P=0.626N P=0.120N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/44 (2%) 1/38 (3%) 1/59 (2%) | 0/57 (0%) 1/29 (3%) 1/30 (3%) 0/60 (0%) |
|ADJUSTED (b) | 6.9% 4.5% 2.1% 3.1% | 0.0% 50.0% 100.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/18 (0%) 0/1 (0%) 0/1 (0%) 0/16 (0%) | 0/26 (0%) 1/2 (50%) 1/1 (100%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 660 705 471 628 | --- 730 (T) 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.549N P=0.522N P=0.465N P=0.528N | P=0.305N P=0.048 * P=0.007 ** (e) |
|INCIDENTAL TUMOR | P=0.540N P=0.529N P=0.444N P=0.548N | P=0.305N P=0.048 * P=0.007 ** (e) |
|LOGISTIC REGRESSION | P=0.458N P=0.733 P=0.660N P=0.522N | P=0.305N P=0.048 * P=0.007 ** (e) |
|COCHRAN-ARMITAGE | P=0.465N | P=0.431N |
|FISHER EXACT | P=0.616N P=0.667N P=0.506N | P=0.337 P=0.345 (e) |
|=================================================================================================================================|
DATE: 09/15/94 EXPERIMENT: 05114 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.01 PPM 0.05 PPM 0.2 | CONTROL 0.01 PPM 0.05 PPM 0.2 |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 16/60 (27%) 11/44 (25%) 11/38 (29%) 19/59 (32%) | 6/57 (11%) 3/29 (10%) 4/30 (13%) 2/60 (3%) |
|ADJUSTED (b) | 59.6% 100.0% 100.0% 62.6% | 20.2% 52.5% 100.0% 5.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 8/18 (44%) 1/1 (100%) 1/1 (100%) 6/16 (38%) | 4/26 (15%) 1/2 (50%) 1/1 (100%) 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | 628 565 471 458 (I) | 681 681 562 617 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.260 P=0.297 P=0.428 P=0.253 | P=0.057N P=0.493 P=0.227 P=0.110N |
|INCIDENTAL TUMOR | P=0.237 P=0.221 P=0.220 P=0.182 | P=0.046N* P=0.391 P=0.167 P=0.098N |
|LOGISTIC REGRESSION | P=0.328 P=0.175 P=0.112 P=0.207 | P=0.041N* P=0.307 P=0.075 P=0.109N |
|COCHRAN-ARMITAGE | P=0.246 | P=0.077N |
|FISHER EXACT | P=0.516N P=0.491 P=0.322 | P=0.646N P=0.474 P=0.120N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/60 (10%) 2/48 (4%) 1/40 (3%) 2/58 (3%) | 5/59 (8%) 5/32 (16%) 3/37 (8%) 4/60 (7%) |
|ADJUSTED (b) | 21.9% 26.7% 50.0% 12.5% | 17.1% 34.0% 33.3% 11.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/18 (11%) 1/4 (25%) 1/2 (50%) 2/16 (13%) | 4/28 (14%) 2/7 (29%) 3/9 (33%) 2/30 (7%) |
|FIRST INCIDENCE (DAYS) | 464 540 730 (T) 730 (T) | 709 654 730 (T) 569 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.166N P=0.345N P=0.204N P=0.168N | P=0.206N P=0.195 P=0.401 P=0.460N |
|INCIDENTAL TUMOR | P=0.162N P=0.290N P=0.263N P=0.163N | P=0.206N P=0.113 P=0.323 P=0.461N |
|LOGISTIC REGRESSION | P=0.209N P=0.275N P=0.225N P=0.166N | P=0.182N P=0.072 P=0.330 P=0.477N |
|COCHRAN-ARMITAGE | P=0.223N | P=0.274N |
|FISHER EXACT | P=0.220N P=0.149N P=0.147N | P=0.241 P=0.632N P=0.489N |
|=================================================================================================================================|
DATE: 09/15/94 EXPERIMENT: 05114 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.01 PPM 0.05 PPM 0.2 | CONTROL 0.01 PPM 0.05 PPM 0.2 |
| | | |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/60 (10%) 2/48 (4%) 1/40 (3%) 2/58 (3%) | 5/59 (8%) 5/32 (16%) 3/37 (8%) 4/60 (7%) |
|ADJUSTED (b) | 21.9% 26.7% 50.0% 12.5% | 17.1% 34.0% 33.3% 11.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/18 (11%) 1/4 (25%) 1/2 (50%) 2/16 (13%) | 4/28 (14%) 2/7 (29%) 3/9 (33%) 2/30 (7%) |
|FIRST INCIDENCE (DAYS) | 464 540 730 (T) 730 (T) | 709 654 730 (T) 569 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.166N P=0.345N P=0.204N P=0.168N | P=0.206N P=0.195 P=0.401 P=0.460N |
|INCIDENTAL TUMOR | P=0.162N P=0.290N P=0.263N P=0.163N | P=0.206N P=0.113 P=0.323 P=0.461N |
|LOGISTIC REGRESSION | P=0.209N P=0.275N P=0.225N P=0.166N | P=0.182N P=0.072 P=0.330 P=0.477N |
|COCHRAN-ARMITAGE | P=0.223N | P=0.274N |
|FISHER EXACT | P=0.220N P=0.149N P=0.147N | P=0.241 P=0.632N P=0.489N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 8/60 (13%) 5/44 (11%) 5/39 (13%) 11/60 (18%) | 2/60 (3%) 1/28 (4%) 0/29 (0%) 1/60 (2%) |
|ADJUSTED (b) | 34.0% 0.0% 56.0% 44.0% | 7.1% 100.0% 0.0% 3.3% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/18 (28%) 0/0 1/2 (50%) 5/16 (31%) | 2/28 (7%) 1/1 (100%) 0/0 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | 458 (I) 635 611 458 (I) | 730 (T) 730 (T) --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.251 P=0.341 P=0.455 P=0.243 | P=0.264N P=0.096 (e) P=0.476N |
|INCIDENTAL TUMOR | P=0.253 P=0.345 P=0.346 P=0.232 | P=0.264N P=0.096 (e) P=0.476N |
|LOGISTIC REGRESSION | P=0.261 P=0.402 P=0.435 P=0.258 | P=0.264N P=0.096 (e) P=0.476N |
|COCHRAN-ARMITAGE | P=0.193 | P=0.443N |
|FISHER EXACT | P=0.505N P=0.597N P=0.309 | P=0.688 P=0.452N P=0.500N |
|=================================================================================================================================|
DATE: 09/15/94 EXPERIMENT: 05114 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.01 PPM 0.05 PPM 0.2 | CONTROL 0.01 PPM 0.05 PPM 0.2 |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 2/44 (5%) 1/39 (3%) 2/60 (3%) | 0/60 (0%) 0/28 (0%) 0/29 (0%) 0/60 (0%) |
|ADJUSTED (b) | 15.6% 0.0% 3.3% 11.1% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/18 (6%) 0/0 0/2 (0%) 0/16 (0%) | 0/28 (0%) 0/1 (0%) 0/0 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 626 544 705 723 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.432N P=0.519N P=0.232N P=0.395N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.403N P=0.483N P=0.336N P=0.375N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.315N P=0.615N P=0.470N P=0.368N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.355N | (e) |
|FISHER EXACT | P=0.495N P=0.342N P=0.340N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/60 (20%) 7/44 (16%) 6/39 (15%) 13/60 (22%) | 2/60 (3%) 1/28 (4%) 0/29 (0%) 1/60 (2%) |
|ADJUSTED (b) | 45.6% 0.0% 57.4% 50.2% | 7.1% 100.0% 0.0% 3.3% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 6/18 (33%) 0/0 1/2 (50%) 5/16 (31%) | 2/28 (7%) 1/1 (100%) 0/0 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | 458 (I) 544 611 458 (I) | 730 (T) 730 (T) --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.362 P=0.471 P=0.478N P=0.403 | P=0.264N P=0.096 (e) P=0.476N |
|INCIDENTAL TUMOR | P=0.378 P=0.507 P=0.593 P=0.397 | P=0.264N P=0.096 (e) P=0.476N |
|LOGISTIC REGRESSION | P=0.436 P=0.473 P=0.581 P=0.431 | P=0.264N P=0.096 (e) P=0.476N |
|COCHRAN-ARMITAGE | P=0.336 | P=0.443N |
|FISHER EXACT | P=0.394N P=0.381N P=0.500 | P=0.688 P=0.452N P=0.500N |
|=================================================================================================================================|
DATE: 09/15/94 EXPERIMENT: 05114 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.01 PPM 0.05 PPM 0.2 | CONTROL 0.01 PPM 0.05 PPM 0.2 |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/49 (2%) 1/46 (2%) 3/60 (5%) | 1/60 (2%) 2/41 (5%) 0/42 (0%) 1/60 (2%) |
|ADJUSTED (b) | 4.3% 3.2% 4.3% 12.0% | 2.9% 8.9% 0.0% 3.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/18 (0%) 0/5 (0%) 0/9 (0%) 0/16 (0%) | 0/28 (0%) 1/14 (7%) 0/13 (0%) 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | 712 639 724 617 | 683 459 (I) --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.133 P=0.745 P=0.731N P=0.281 | P=0.514N P=0.438 P=0.506N P=0.750N |
|INCIDENTAL TUMOR | P=0.146 P=0.752 P=0.748N P=0.275 | P=0.529N P=0.405 P=0.705N P=0.732 |
|LOGISTIC REGRESSION | P=0.208 P=0.668 P=0.668 P=0.282 | P=0.515N P=0.374 P=0.618N P=0.758N |
|COCHRAN-ARMITAGE | P=0.197 | P=0.521N |
|FISHER EXACT | P=0.699 P=0.682 P=0.309 | P=0.359 P=0.588N P=0.752N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/49 (2%) 1/46 (2%) 3/60 (5%) | 1/60 (2%) 2/41 (5%) 1/42 (2%) 1/60 (2%) |
|ADJUSTED (b) | 4.3% 3.2% 4.3% 12.0% | 2.9% 8.9% 7.7% 3.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/18 (0%) 0/5 (0%) 0/9 (0%) 0/16 (0%) | 0/28 (0%) 1/14 (7%) 1/13 (8%) 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | 712 639 724 617 | 683 459 (I) 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.133 P=0.745 P=0.731N P=0.281 | P=0.451N P=0.438 P=0.675 P=0.750N |
|INCIDENTAL TUMOR | P=0.146 P=0.752 P=0.748N P=0.275 | P=0.464N P=0.405 P=0.550 P=0.732 |
|LOGISTIC REGRESSION | P=0.208 P=0.668 P=0.668 P=0.282 | P=0.458N P=0.374 P=0.601 P=0.758N |
|COCHRAN-ARMITAGE | P=0.197 | P=0.474N |
|FISHER EXACT | P=0.699 P=0.682 P=0.309 | P=0.359 P=0.656 P=0.752N |
|=================================================================================================================================|
DATE: 09/15/94 EXPERIMENT: 05114 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.01 PPM 0.05 PPM 0.2 | CONTROL 0.01 PPM 0.05 PPM 0.2 |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/49 (2%) 1/46 (2%) 3/60 (5%) | 1/60 (2%) 2/41 (5%) 1/42 (2%) 1/60 (2%) |
|ADJUSTED (b) | 4.3% 3.2% 4.3% 12.0% | 2.9% 8.9% 7.7% 3.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/18 (0%) 0/5 (0%) 0/9 (0%) 0/16 (0%) | 0/28 (0%) 1/14 (7%) 1/13 (8%) 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | 712 639 724 617 | 683 459 (I) 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.133 P=0.745 P=0.731N P=0.281 | P=0.451N P=0.438 P=0.675 P=0.750N |
|INCIDENTAL TUMOR | P=0.146 P=0.752 P=0.748N P=0.275 | P=0.464N P=0.405 P=0.550 P=0.732 |
|LOGISTIC REGRESSION | P=0.208 P=0.668 P=0.668 P=0.282 | P=0.458N P=0.374 P=0.601 P=0.758N |
|COCHRAN-ARMITAGE | P=0.197 | P=0.474N |
|FISHER EXACT | P=0.699 P=0.682 P=0.309 | P=0.359 P=0.656 P=0.752N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 2/60 (3%) 2/60 (3%) 3/60 (5%) | 1/60 (2%) 0/60 (0%) 0/59 (0%) 0/60 (0%) |
|ADJUSTED (b) | 23.5% 12.5% 9.1% 15.4% | 3.4% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/18 (17%) 2/16 (13%) 2/22 (9%) 2/16 (13%) | 0/28 (0%) 0/33 (0%) 0/30 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 694 730 (T) 730 (T) 639 | 726 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.577N P=0.258N P=0.145N P=0.413N | P=0.542N P=0.474N P=0.493N P=0.480N |
|INCIDENTAL TUMOR | P=0.573N P=0.248N P=0.154N P=0.414N | P=0.583N P=0.531N P=0.705N P=0.567N |
|LOGISTIC REGRESSION | P=0.569N P=0.233N P=0.150N P=0.397N | P=0.549N P=0.475N P=0.506N P=0.489N |
|COCHRAN-ARMITAGE | P=0.522N | P=0.549N |
|FISHER EXACT | P=0.219N P=0.219N P=0.359N | P=0.500N P=0.504N P=0.500N |
|=================================================================================================================================|
DATE: 09/15/94 EXPERIMENT: 05114 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.01 PPM 0.05 PPM 0.2 | CONTROL 0.01 PPM 0.05 PPM 0.2 |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 1/59 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 11.8% | 0.0% 0.0% 2.6% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/18 (0%) 0/16 (0%) 0/22 (0%) 1/16 (6%) | 0/28 (0%) 0/33 (0%) 0/30 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 724 | --- --- 597 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.030 * (e) (e) P=0.210 | P=0.770N (e) P=0.467 (e) |
|INCIDENTAL TUMOR | P=0.033 * (e) (e) P=0.218 | P=0.710N (e) P=0.701 (e) |
|LOGISTIC REGRESSION | P=0.030 * (e) (e) P=0.212 | P=0.779N (e) P=0.505 (e) |
|COCHRAN-ARMITAGE | P=0.042 * | P=0.773N |
|FISHER EXACT | (e) (e) P=0.248 | (e) P=0.496 (e) |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 2/60 (3%) 2/60 (3%) 5/60 (8%) | 1/60 (2%) 0/60 (0%) 1/59 (2%) 0/60 (0%) |
|ADJUSTED (b) | 23.5% 12.5% 9.1% 26.1% | 3.4% 0.0% 2.6% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/18 (17%) 2/16 (13%) 2/22 (9%) 3/16 (19%) | 0/28 (0%) 0/33 (0%) 0/30 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 694 730 (T) 730 (T) 639 | 726 --- 597 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.258 P=0.258N P=0.145N P=0.561 | P=0.478N P=0.474N P=0.746 P=0.480N |
|INCIDENTAL TUMOR | P=0.265 P=0.248N P=0.154N P=0.566 | P=0.452N P=0.531N P=0.787 P=0.567N |
|LOGISTIC REGRESSION | P=0.266 P=0.233N P=0.150N P=0.583 | P=0.482N P=0.475N P=0.755 P=0.489N |
|COCHRAN-ARMITAGE | P=0.321 | P=0.482N |
|FISHER EXACT | P=0.219N P=0.219N P=0.628N | P=0.500N P=0.748 P=0.500N |
|=================================================================================================================================|
DATE: 09/15/94 EXPERIMENT: 05114 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.01 PPM 0.05 PPM 0.2 | CONTROL 0.01 PPM 0.05 PPM 0.2 |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 3/60 (5%) 1/60 (2%) 4/60 (7%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 9.6% 3.0% 12.8% 2.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/18 (0%) 0/16 (0%) 0/22 (0%) 0/16 (0%) | 2/28 (7%) 1/33 (3%) 3/30 (10%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 680 730 (T) 709 626 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.342N P=0.257N P=0.521 P=0.304N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.337N P=0.276N P=0.377 P=0.264N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.337N P=0.273N P=0.462 P=0.299N |
|COCHRAN-ARMITAGE | (e) | P=0.336N |
|FISHER EXACT | (e) (e) (e) | P=0.309N P=0.500 P=0.309N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 13/60 (22%) 20/60 (33%) 14/60 (23%) 13/60 (22%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 38.5% 52.8% 36.9% 34.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 1/10 (10%) 1/10 (10%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 0/18 (0%) 0/16 (0%) 0/22 (0%) 0/16 (0%) | 9/28 (32%) 16/33 (48%) 8/30 (27%) 8/30 (27%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 459 (I) 459 (I) 459 (I) 528 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.287N P=0.219 P=0.528 P=0.534N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.263N P=0.144 P=0.495 P=0.552N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.265N P=0.141 P=0.441 P=0.571N |
|COCHRAN-ARMITAGE | (e) | P=0.273N |
|FISHER EXACT | (e) (e) (e) | P=0.110 P=0.500 P=0.588N |
|=================================================================================================================================|
DATE: 09/15/94 EXPERIMENT: 05114 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.01 PPM 0.05 PPM 0.2 | CONTROL 0.01 PPM 0.05 PPM 0.2 |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 15/60 (25%) 20/60 (33%) 16/60 (27%) 14/60 (23%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 44.9% 52.8% 42.6% 36.2% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 1/10 (10%) 1/10 (10%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 0/18 (0%) 0/16 (0%) 0/22 (0%) 0/16 (0%) | 11/28 (39%) 16/33 (48%) 10/30 (33%) 8/30 (27%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 459 (I) 459 (I) 459 (I) 528 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.278N P=0.375 P=0.539 P=0.446N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.243N P=0.277 P=0.508 P=0.428N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.255N P=0.265 P=0.425 P=0.480N |
|COCHRAN-ARMITAGE | (e) | P=0.263N |
|FISHER EXACT | (e) (e) (e) | P=0.211 P=0.500 P=0.500N |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 2/60 (3%) 1/60 (2%) | 1/60 (2%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 6.3% 3.8% | 3.4% 0.0% 2.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/18 (0%) 0/16 (0%) 0/22 (0%) 0/16 (0%) | 0/28 (0%) 0/33 (0%) 0/30 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 680 681 | 726 --- 569 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.390 (e) P=0.288 P=0.485 | P=0.474N P=0.474N P=0.754 P=0.480N |
|INCIDENTAL TUMOR | P=0.385 (e) P=0.252 P=0.484 | P=0.452N P=0.531N P=0.787 P=0.567N |
|LOGISTIC REGRESSION | P=0.398 (e) P=0.248 P=0.489 | P=0.482N P=0.475N P=0.760 P=0.489N |
|COCHRAN-ARMITAGE | P=0.414 | P=0.482N |
|FISHER EXACT | (e) P=0.248 P=0.500 | P=0.500N P=0.752N P=0.500N |
|=================================================================================================================================|
DATE: 09/15/94 EXPERIMENT: 05114 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.01 PPM 0.05 PPM 0.2 | CONTROL 0.01 PPM 0.05 PPM 0.2 |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 27/60 (45%) 23/49 (47%) 23/48 (48%) 36/60 (60%) | 32/60 (53%) 30/49 (61%) 25/43 (58%) 40/60 (67%) |
|ADJUSTED (b) | 69.0% 100.0% 84.5% 94.2% | 73.6% 89.7% 100.0% 86.4% |
|INTERIM SACRIFICE 1 (c)| 4/10 (40%) 0/10 (0%) 0/10 (0%) 3/10 (30%) | 1/10 (10%) 0/10 (0%) 2/10 (20%) 2/10 (20%) |
|TERMINAL (d) | 8/18 (44%) 5/5 (100%) 9/12 (75%) 14/16 (88%) | 17/28 (61%) 19/22 (86%) 14/14 (100%) 24/30 (80%) |
|FIRST INCIDENCE (DAYS) | 458 (I) 355 547 458 (I) | 459 (I) 521 366 459 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.048 * P=0.316 P=0.415N P=0.061 | P=0.190 P=0.493 P=0.269 P=0.199 |
|INCIDENTAL TUMOR | P=0.032 * P=0.393 P=0.348 P=0.036 * | P=0.130 P=0.176 P=0.119 P=0.124 |
|LOGISTIC REGRESSION | P=0.034 * P=0.288 P=0.342 P=0.040 * | P=0.158 P=0.217 P=0.069 P=0.122 |
|COCHRAN-ARMITAGE | P=0.047 * | P=0.120 |
|FISHER EXACT | P=0.496 P=0.457 P=0.072 | P=0.264 P=0.389 P=0.096 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/49 (0%) 0/48 (0%) 0/60 (0%) | 2/60 (3%) 1/49 (2%) 0/43 (0%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 6.2% 2.5% 0.0% 3.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/18 (0%) 0/5 (0%) 0/12 (0%) 0/16 (0%) | 1/28 (4%) 0/22 (0%) 0/14 (0%) 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 681 683 --- 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.525N P=0.500N P=0.325N P=0.487N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.552N P=0.564N P=0.441N P=0.523N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.502N P=0.573N P=0.385N P=0.492N |
|COCHRAN-ARMITAGE | (e) | P=0.521N |
|FISHER EXACT | (e) (e) (e) | P=0.576N P=0.337N P=0.500N |
|=================================================================================================================================|
DATE: 09/15/94 EXPERIMENT: 05114 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.01 PPM 0.05 PPM 0.2 | CONTROL 0.01 PPM 0.05 PPM 0.2 |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) 2/60 (3%) 3/60 (5%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 6.8% 6.3% 8.5% 16.7% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/18 (0%) 1/16 (6%) 1/22 (5%) 2/16 (13%) | 0/28 (0%) 0/33 (0%) 0/30 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 536 730 (T) 723 709 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.261 P=0.524N P=0.656N P=0.454 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.272 P=0.475N P=0.631N P=0.494 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.273 P=0.510N P=0.687N P=0.473 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.303 | (e) |
|FISHER EXACT | P=0.500N P=0.691N P=0.500 | (e) (e) (e) |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 0/60 (0%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 5.6% 3.6% 0.0% 8.4% | 0.0% 0.0% 3.3% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/18 (6%) 0/16 (0%) 0/22 (0%) 1/16 (6%) | 0/28 (0%) 0/33 (0%) 1/30 (3%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 662 --- 534 | --- --- 730 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.292 P=0.747 P=0.460N P=0.465 | P=0.775N (e) P=0.514 (e) |
|INCIDENTAL TUMOR | P=0.306 P=0.747 P=0.460N P=0.511 | P=0.775N (e) P=0.514 (e) |
|LOGISTIC REGRESSION | P=0.307 P=0.753 P=0.460N P=0.484 | P=0.775N (e) P=0.514 (e) |
|COCHRAN-ARMITAGE | P=0.319 | P=0.773N |
|FISHER EXACT | P=0.752N P=0.500N P=0.500 | (e) P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/15/94 EXPERIMENT: 05114 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.01 PPM 0.05 PPM 0.2 | CONTROL 0.01 PPM 0.05 PPM 0.2 |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 0/60 (0%) 3/60 (5%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 1/60 (2%) |
|ADJUSTED (b) | 5.6% 3.6% 0.0% 14.5% | 0.0% 0.0% 3.3% 3.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/18 (6%) 0/16 (0%) 0/22 (0%) 2/16 (13%) | 0/28 (0%) 0/33 (0%) 1/30 (3%) 1/30 (3%) |
|FIRST INCIDENCE (DAYS) | 730 (T) 662 --- 534 | --- --- 730 (T) 730 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.097 P=0.747 P=0.460N P=0.268 | P=0.343 (e) P=0.514 P=0.514 |
|INCIDENTAL TUMOR | P=0.104 P=0.747 P=0.460N P=0.302 | P=0.343 (e) P=0.514 P=0.514 |
|LOGISTIC REGRESSION | P=0.107 P=0.753 P=0.460N P=0.284 | P=0.343 (e) P=0.514 P=0.514 |
|COCHRAN-ARMITAGE | P=0.118 | P=0.345 |
|FISHER EXACT | P=0.752N P=0.500N P=0.309 | (e) P=0.500 P=0.500 |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 47/60 (78%) 36/58 (62%) 34/58 (59%) 44/60 (73%) | |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 94.8% | |
|INTERIM SACRIFICE 1 (c)| 9/10 (90%) 2/10 (20%) 1/10 (10%) 10/10 (100%)| |
|TERMINAL (d) | 18/18 (100%) 14/14 (100%) 21/21 (100%) 14/16 (88%) | |
|FIRST INCIDENCE (DAYS) | 458 (I) 355 402 458 (I) | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.214 P=0.216N P=0.004N** P=0.533 | |
|INCIDENTAL TUMOR | P=0.250 P=0.061N P=0.003N** P=0.518N | |
|LOGISTIC REGRESSION | P=0.263 P=0.056N P=0.012N* P=0.395N | |
|COCHRAN-ARMITAGE | P=0.349 | |
|FISHER EXACT | P=0.041N* P=0.017N* P=0.335N | |
|=================================================================================================================================|
DATE: 09/15/94 EXPERIMENT: 05114 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.01 PPM 0.05 PPM 0.2 | CONTROL 0.01 PPM 0.05 PPM 0.2 |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/59 (8%) 3/45 (7%) 5/42 (12%) 3/60 (5%) | 6/60 (10%) 3/29 (10%) 1/29 (3%) 5/60 (8%) |
|ADJUSTED (b) | 20.2% 10.6% 76.5% 15.2% | 19.6% 6.4% 0.0% 15.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/18 (11%) 0/1 (0%) 3/4 (75%) 2/16 (13%) | 5/28 (18%) 0/2 (0%) 0/0 4/30 (13%) |
|FIRST INCIDENCE (DAYS) | 626 584 680 621 | 625 621 562 668 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.250N P=0.644N P=0.263 P=0.413N | P=0.351N P=0.463 P=0.726 P=0.467N |
|INCIDENTAL TUMOR | P=0.235N P=0.627N P=0.170 P=0.401N | P=0.313N P=0.411 P=0.522N P=0.439N |
|LOGISTIC REGRESSION | P=0.240N P=0.617 P=0.204 P=0.385N | P=0.370N P=0.447 P=0.635N P=0.485N |
|COCHRAN-ARMITAGE | P=0.295N | P=0.497N |
|FISHER EXACT | P=0.517N P=0.404 P=0.349N | P=0.613 P=0.267N P=0.500N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/59 (0%) 1/45 (2%) 3/42 (7%) 3/60 (5%) | 0/60 (0%) 1/29 (3%) 3/29 (10%) 4/60 (7%) |
|ADJUSTED (b) | 0.0% 2.6% 28.9% 16.0% | 0.0% 50.0% 0.0% 12.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/18 (0%) 0/1 (0%) 1/4 (25%) 1/16 (6%) | 0/28 (0%) 1/2 (50%) 0/0 3/30 (10%) |
|FIRST INCIDENCE (DAYS) | --- 597 458 (I) 709 | --- 730 (T) 549 726 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.186 P=0.490 P=0.061 P=0.103 | P=0.191 P=0.041 * P=0.118 P=0.074 |
|INCIDENTAL TUMOR | P=0.194 P=0.500 P=0.053 P=0.105 | P=0.206 P=0.041 * P=0.151 P=0.060 |
|LOGISTIC REGRESSION | P=0.215 P=0.451 P=0.055 P=0.103 | P=0.201 P=0.041 * P=0.018 * P=0.072 |
|COCHRAN-ARMITAGE | P=0.194 | P=0.139 |
|FISHER EXACT | P=0.433 P=0.069 P=0.125 | P=0.326 P=0.032 * P=0.059 |
|=================================================================================================================================|
DATE: 09/15/94 EXPERIMENT: 05114 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.01 PPM 0.05 PPM 0.2 | CONTROL 0.01 PPM 0.05 PPM 0.2 |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/59 (8%) 3/45 (7%) 8/42 (19%) 6/60 (10%) | 6/60 (10%) 4/29 (14%) 4/29 (14%) 9/60 (15%) |
|ADJUSTED (b) | 20.2% 10.6% 100.0% 29.4% | 19.6% 53.2% 0.0% 27.7% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/18 (11%) 0/1 (0%) 4/4 (100%) 3/16 (19%) | 5/28 (18%) 1/2 (50%) 0/0 7/30 (23%) |
|FIRST INCIDENCE (DAYS) | 626 584 458 (I) 621 | 625 621 549 668 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.550 P=0.644N P=0.047 * P=0.428 | P=0.486 P=0.182 P=0.161 P=0.328 |
|INCIDENTAL TUMOR | P=0.569 P=0.627N P=0.020 * P=0.442 | P=0.534 P=0.143 P=0.368 P=0.326 |
|LOGISTIC REGRESSION | P=0.572 P=0.617 P=0.029 * P=0.458 | P=0.473 P=0.218 P=0.133 P=0.302 |
|COCHRAN-ARMITAGE | P=0.499 | P=0.317 |
|FISHER EXACT | P=0.517N P=0.104 P=0.512 | P=0.419 P=0.419 P=0.291 |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/59 (0%) 1/45 (2%) 0/42 (0%) 3/60 (5%) | 1/60 (2%) 0/29 (0%) 0/29 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 100.0% 0.0% 15.4% | 3.6% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/18 (0%) 1/1 (100%) 0/4 (0%) 2/16 (13%) | 1/28 (4%) 0/2 (0%) 0/0 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | --- 730 (T) --- 639 | 730 (T) --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.120 P=0.023 * (e) P=0.106 | P=0.400N P=0.959N (e) P=0.486N |
|INCIDENTAL TUMOR | P=0.130 P=0.023 * (e) P=0.108 | P=0.400N P=0.959N (e) P=0.486N |
|LOGISTIC REGRESSION | P=0.090 P=0.023 * (e) P=0.109 | P=0.400N P=0.959N (e) P=0.486N |
|COCHRAN-ARMITAGE | P=0.066 | P=0.490N |
|FISHER EXACT | P=0.433 (e) P=0.125 | P=0.674N P=0.674N P=0.500N |
|=================================================================================================================================|
DATE: 09/15/94 EXPERIMENT: 05114 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.01 PPM 0.05 PPM 0.2 | CONTROL 0.01 PPM 0.05 PPM 0.2 |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/59 (0%) 1/45 (2%) 0/42 (0%) 3/60 (5%) | 1/60 (2%) 1/29 (3%) 0/29 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 100.0% 0.0% 15.4% | 3.6% 50.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/18 (0%) 1/1 (100%) 0/4 (0%) 2/16 (13%) | 1/28 (4%) 1/2 (50%) 0/0 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | --- 730 (T) --- 639 | 730 (T) 730 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.120 P=0.023 * (e) P=0.106 | P=0.204N P=0.145 (e) P=0.486N |
|INCIDENTAL TUMOR | P=0.130 P=0.023 * (e) P=0.108 | P=0.204N P=0.145 (e) P=0.486N |
|LOGISTIC REGRESSION | P=0.090 P=0.023 * (e) P=0.109 | P=0.204N P=0.145 (e) P=0.486N |
|COCHRAN-ARMITAGE | P=0.066 | P=0.290N |
|FISHER EXACT | P=0.433 (e) P=0.125 | P=0.548 P=0.674N P=0.500N |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 4/60 (7%) 5/60 (8%) 5/60 (8%) 8/60 (13%) |
|ADJUSTED (b) | | 13.3% 14.2% 13.6% 22.2% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | | 3/28 (11%) 4/33 (12%) 2/30 (7%) 4/30 (13%) |
|FIRST INCIDENCE (DAYS) | | 686 659 459 (I) 628 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.135 P=0.592 P=0.513 P=0.209 |
|INCIDENTAL TUMOR | | P=0.113 P=0.558 P=0.326 P=0.170 |
|LOGISTIC REGRESSION | | P=0.136 P=0.555 P=0.466 P=0.187 |
|COCHRAN-ARMITAGE | | P=0.135 |
|FISHER EXACT | | P=0.500 P=0.500 P=0.181 |
|=================================================================================================================================|
DATE: 09/15/94 EXPERIMENT: 05114 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.01 PPM 0.05 PPM 0.2 | CONTROL 0.01 PPM 0.05 PPM 0.2 |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 5/60 (8%) 5/60 (8%) 5/60 (8%) 8/60 (13%) |
|ADJUSTED (b) | | 16.8% 14.2% 13.6% 22.2% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | | 4/28 (14%) 4/33 (12%) 2/30 (7%) 4/30 (13%) |
|FIRST INCIDENCE (DAYS) | | 686 659 459 (I) 628 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.181 P=0.533N P=0.611N P=0.314 |
|INCIDENTAL TUMOR | | P=0.156 P=0.566N P=0.471 P=0.270 |
|LOGISTIC REGRESSION | | P=0.184 P=0.574N P=0.593 P=0.288 |
|COCHRAN-ARMITAGE | | P=0.183 |
|FISHER EXACT | | P=0.628N P=0.628N P=0.279 |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 2/60 (3%) 1/60 (2%) 0/60 (0%) | 1/60 (2%) 1/60 (2%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 7.1% 5.1% 2.2% 0.0% | 3.6% 2.1% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/18 (0%) 0/16 (0%) 0/22 (0%) 0/16 (0%) | 1/28 (4%) 0/33 (0%) 0/30 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 548 379 506 --- | 730 (T) 621 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.169N P=0.673 P=0.500N P=0.268N | P=0.352N P=0.737N P=0.486N P=0.486N |
|INCIDENTAL TUMOR | P=0.150N P=0.670N P=0.565N P=0.257N | P=0.295N P=0.742N P=0.486N P=0.486N |
|LOGISTIC REGRESSION | P=0.140N P=0.679N P=0.494N P=0.242N | P=0.345N P=0.757N P=0.486N P=0.486N |
|COCHRAN-ARMITAGE | P=0.155N | P=0.345N |
|FISHER EXACT | P=0.691N P=0.500N P=0.248N | P=0.752N P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/15/94 EXPERIMENT: 05114 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.01 PPM 0.05 PPM 0.2 | CONTROL 0.01 PPM 0.05 PPM 0.2 |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 29/60 (48%) 33/60 (55%) 26/60 (43%) 29/60 (48%) | 16/60 (27%) 14/60 (23%) 18/60 (30%) 21/60 (35%) |
|ADJUSTED (b) | 72.6% 79.2% 65.2% 76.1% | 40.6% 30.1% 43.4% 55.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 8/18 (44%) 8/16 (50%) 9/22 (41%) 8/16 (50%) | 6/28 (21%) 3/33 (9%) 8/30 (27%) 14/30 (47%) |
|FIRST INCIDENCE (DAYS) | 536 370 506 460 | 639 521 366 569 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.484 P=0.258 P=0.210N P=0.416 | P=0.135 P=0.306N P=0.414 P=0.290 |
|INCIDENTAL TUMOR | P=0.510N P=0.186 P=0.532N P=0.489 | P=0.085 P=0.509N P=0.173 P=0.158 |
|LOGISTIC REGRESSION | P=0.482N P=0.194 P=0.507 P=0.476 | P=0.138 P=0.422N P=0.356 P=0.220 |
|COCHRAN-ARMITAGE | P=0.436N | P=0.113 |
|FISHER EXACT | P=0.292 P=0.357N P=0.572N | P=0.417N P=0.420 P=0.215 |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 5/60 (8%) 0/60 (0%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 4.3% 20.6% 0.0% 5.9% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/18 (0%) 1/16 (6%) 0/22 (0%) 0/16 (0%) | 0/28 (0%) 0/33 (0%) 0/30 (0%) 0/30 (0%) |
|FIRST INCIDENCE (DAYS) | 712 597 --- 542 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.546N P=0.093 P=0.476N P=0.466 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.530N P=0.094 P=0.485N P=0.520 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.525N P=0.093 P=0.478N P=0.493 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.509N | (e) |
|FISHER EXACT | P=0.103 P=0.500N P=0.500 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/15/94 EXPERIMENT: 05114 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.01 PPM 0.05 PPM 0.2 | CONTROL 0.01 PPM 0.05 PPM 0.2 |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 56/60 (93%) 47/60 (78%) 47/60 (78%) 57/60 (95%) | 46/60 (77%) 44/60 (73%) 39/60 (65%) 48/60 (80%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 92.0% 93.5% 80.9% 95.9% |
|INTERIM SACRIFICE 1 (c)| 10/10 (100%) 2/10 (20%) 1/10 (10%) 10/10 (100%)| 2/10 (20%) 2/10 (20%) 3/10 (30%) 2/10 (20%) |
|TERMINAL (d) | 18/18 (100%) 16/16 (100%) 22/22 (100%) 16/16 (100%)| 24/28 (86%) 30/33 (91%) 21/30 (70%) 28/30 (93%) |
|FIRST INCIDENCE (DAYS) | 458 (I) 355 402 458 (I) | 459 (I) 459 (I) 366 459 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.091 P=0.268N P=0.030N* P=0.292 | P=0.272 P=0.140N P=0.195N P=0.554 |
|INCIDENTAL TUMOR | P=0.007 ** P=0.016N* P=0.013N* P=0.148 | P=0.189 P=0.321N P=0.159N P=0.476 |
|LOGISTIC REGRESSION | P=0.007 ** P=0.018N* P=0.018N* P=0.266 | P=0.291 P=0.209N P=0.145N P=0.618 |
|COCHRAN-ARMITAGE | P=0.053 | P=0.227 |
|FISHER EXACT | P=0.017N* P=0.017N* P=0.500 | P=0.417N P=0.114N P=0.412 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 36/60 (60%) 38/60 (63%) 33/60 (55%) 34/60 (57%) | 29/60 (48%) 26/60 (43%) 27/60 (45%) 28/60 (47%) |
|ADJUSTED (b) | 79.0% 83.9% 75.3% 79.4% | 65.3% 52.7% 60.4% 67.8% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 2/10 (20%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 9/18 (50%) 9/16 (56%) 12/22 (55%) 8/16 (50%) | 13/28 (46%) 10/33 (30%) 13/30 (43%) 17/30 (57%) |
|FIRST INCIDENCE (DAYS) | 373 370 458 (I) 180 | 376 521 366 569 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.530N P=0.347 P=0.213N P=0.506 | P=0.496 P=0.214N P=0.451N P=0.415N |
|INCIDENTAL TUMOR | P=0.350N P=0.364 P=0.516N P=0.422N | P=0.501 P=0.472N P=0.584N P=0.559 |
|LOGISTIC REGRESSION | P=0.400N P=0.321 P=0.567N P=0.506N | P=0.497N P=0.301N P=0.503N P=0.459N |
|COCHRAN-ARMITAGE | P=0.335N | P=0.510 |
|FISHER EXACT | P=0.426 P=0.356N P=0.427N | P=0.357N P=0.427N P=0.500N |
|=================================================================================================================================|
DATE: 09/15/94 EXPERIMENT: 05114 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROCYCLOPENTADIENE (HCCPD)
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.01 PPM 0.05 PPM 0.2 | CONTROL 0.01 PPM 0.05 PPM 0.2 |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 60/60 (100%) 51/60 (85%) 51/60 (85%) 59/60 (98%) | 49/60 (82%) 50/60 (83%) 44/60 (73%) 51/60 (85%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 96.0% 96.1% 87.9% 98.1% |
|INTERIM SACRIFICE 1 (c)| 10/10 (100%) 2/10 (20%) 3/10 (30%) 10/10 (100%)| 2/10 (20%) 2/10 (20%) 3/10 (30%) 2/10 (20%) |
|TERMINAL (d) | 18/18 (100%) 16/16 (100%) 22/22 (100%) 16/16 (100%)| 26/28 (93%) 31/33 (94%) 24/30 (80%) 29/30 (97%) |
|FIRST INCIDENCE (DAYS) | 373 355 402 180 | 376 459 (I) 366 459 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.161 P=0.286N P=0.037N* P=0.385 | P=0.367 P=0.258N P=0.278N P=0.548N |
|INCIDENTAL TUMOR | P=0.028 * P<0.001N** P=0.003N** (e) | P=0.314 P=0.539 P=0.190N P=0.387 |
|LOGISTIC REGRESSION | P=0.022 * P=0.003N** P=0.003N** P=0.996N | P=0.474 P=0.488N P=0.311N P=0.565 |
|COCHRAN-ARMITAGE | P=0.105 | P=0.330 |
|FISHER EXACT | P=0.001N** P=0.001N** P=0.500N | P=0.500 P=0.191N P=0.404 |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 458
Female interim sacrifices(days): 459
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).