TDMS Study 05114-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/14/94
EXP: 05114 HEXACHLOROCYCLOPENTADIENE (HCCPD) TIME: 13:49:13
TEST: 01 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 00125
CONT: NO1ES2800301 CAS: 77-47-4
PATHOLOGIST: R. RENNE HAILEY, JAMES R.
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
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REMOVAL DATE RANGE:
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TREATMENT GROUPS:
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DATE: 09/14/94
EXP: 05114 HEXACHLOROCYCLOPENTADIENE (HCCPD) TIME: 13:49:13
TEST: 01 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: RESPIRATORY EXPOSURE WHOLE NTP C#: 00125
CONT: NO1ES2800301 CAS: 77-47-4
PATHOLOGIST: R. RENNE HAILEY, JAMES R.
HEXACHLOROCYCLOPENTADIENE (HCCPD)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 32 CENSORED DEATHS 10 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 373 464 481 536 544 548 565 569 591 597 |
| 597 600 617 624 625 626 628 633 635 651 |
| 660 661 681 683 691 694 698 712 712 719 |
| 724 729 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.01 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 34 CENSORED DEATHS 10 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 355 370 379 451 523 540 541 544 564 565 |
| 584 597 600 600 615 628 634 635 636 639 |
| 639 649 662 670 681 695 698 704 705 709 |
| 719 724 724 726 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.05 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 28 CENSORED DEATHS 10 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 233 365 402 471 506 506 516 535 541 547 |
| 565 597 611 635 649 664 666 680 701 704 |
| 705 705 709 710 712 712 723 724 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 458 |
| |
==================================================================================
HEXACHLOROCYCLOPENTADIENE (HCCPD)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.2 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 34 CENSORED DEATHS 10 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 180 220 460 474 485 500 534 541 542 582 |
| 585 589 600 600 612 617 620 621 628 628 |
| 639 639 653 668 681 683 695 704 704 709 |
| 712 719 723 724 |
| CENSORED DEATHS |
| 458 458 458 458 458 458 458 458 458 458 |
| |
==================================================================================
HEXACHLOROCYCLOPENTADIENE (HCCPD)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 98.3 94.3 90.3 76.3 56.2 36.1 |
| | |
| | |
|0.01 PPM | 100.0 100.0 100.0 98.3 95.0 93.3 85.2 73.0 54.8 32.5 |
| | |
| | |
|0.05 PPM | 100.0 100.0 98.3 96.7 95.0 93.0 82.9 76.8 68.7 44.5 |
| | |
| | |
|0.2 | 100.0 98.3 96.7 96.7 96.7 90.6 82.6 72.5 54.4 32.2 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.01 PPM 0.05 PPM 0.2 |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 36.1% 32.5% 44.5% 32.2% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.649 P=0.775 P=0.513N P=0.679 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 620.9 609.0 599.8 596.2 |
|NATURAL DEATHS (C) | (14.5) (17.4) (23.7) (21.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 626.5 616.1 623.9 608.9 |
|(STANDARD ERROR) | (13.9) (15.0) (16.5) (16.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
HEXACHLOROCYCLOPENTADIENE (HCCPD)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 22 CENSORED DEATHS 10 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 376 376 488 502 625 639 639 640 653 660 |
| 663 677 680 681 681 683 686 703 705 709 |
| 719 726 |
| CENSORED DEATHS |
| 459 459 459 459 459 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.01 PPM |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 17 CENSORED DEATHS 10 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 521 565 621 625 638 654 654 659 668 681 |
| 683 691 694 705 709 724 724 |
| CENSORED DEATHS |
| 459 459 459 459 459 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.05 PPM |
| --------------------- |
| |
| TOTAL 59 UNCENSORED DEATHS 19 CENSORED DEATHS 10 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 366 367 402 549 550 561 562 569 585 590 |
| 597 611 618 642 652 695 695 709 718 |
| CENSORED DEATHS |
| 459 459 459 459 459 459 459 459 459 459 |
| |
==================================================================================
HEXACHLOROCYCLOPENTADIENE (HCCPD)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.2 |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 10 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 528 541 569 588 597 617 625 626 628 635 |
| 658 667 667 668 696 710 710 724 726 726 |
| CENSORED DEATHS |
| 459 459 459 459 459 459 459 459 459 459 |
| |
==================================================================================
HEXACHLOROCYCLOPENTADIENE (HCCPD)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 96.7 96.7 92.6 92.6 78.5 56.4 |
| | |
| | |
|0.01 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 96.0 84.0 66.0 |
| | |
| | |
|0.05 PPM | 100.0 100.0 100.0 100.0 94.9 94.9 94.9 78.4 70.2 61.9 |
| | |
| | |
|0.2 | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 90.0 78.0 60.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 0.01 PPM 0.05 PPM 0.2 |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 56.4% 66.0% 61.9% 60.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000 P=0.361N P=0.958N P=0.843N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 632.3 659.8 580.9 645.3 |
|NATURAL DEATHS (C) | (21.7) (13.2) (24.2) (13.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 649.0 664.9 636.1 656.6 |
|(STANDARD ERROR) | (14.7) (13.1) (15.6) (13.3) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
HEXACHLOROCYCLOPENTADIENE (HCCPD)
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.01 PPM = 2
0.05 PPM = 3
0.2 = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 3 2 1
| 4 4 3 2 21 2 3 41 1
| 2 3 24 31 1
| 2 3 4 3 2 11
90 + 4 433 11
| 4 3 341 11
P | 32 21 1
E | 33 4 11
R 80 + 3 2 2 2
C | 4 41 31
E | 3113
N | 2 2 3 3
T 70 + 2422 3 3
| 33 3
S | 411 3 3
U | 121
R 60 + 4 21 1
V | 424 2 33
I | 4 12 1
V | 2 11
A 50 + 211
L | 4 223 3
| 1 1 3 3
| 211
40 + 211
| 421 1
| 1
| 2 2
30 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 52 obs hidden.
HEXACHLOROCYCLOPENTADIENE (HCCPD)
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
0.01 PPM = 2
0.05 PPM = 3
0.2 = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 31 24
|
| 24 4 2
| 31 3 1 4 24 2
95 + 3 1 1 3
| 4 4 22
| 1 4 4 1 2
| 3 3 1 1
90 + 4 4 2 2
|
P | 44
E | 33 2 2
R 85 + 3 3 1 1
C | 22
E | 3 3 44 1 12 2
N |
T 80 + 33 4 4
| 3 3 1 1
S | 4 4 22
U | 33 1122
R 75 +
V | 3 3 22
I | 3 3 4 422
V |
A 70 + 3 3 2 2
L |
|
| 1 313 2 2
65 +
| 33
| 113 3
|
60 + 114 4
| 11
|
| 1 1
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 8 obs hidden.