TDMS Study 05119-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
DIETHYLPHTHALATE/DIMETHYLPHTHALATE
NTP Experiment-Test: 05119-01 Report: PEIRPT03
Study Type: INIT/PROMOT Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
Facility: Hazleton, Maryland
Chemical CAS #: 84-66-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE ACETONE/ ACETONE/ ACETONE/ ACETONE/ DMBA/TPA DMBA/ACE
TPA DEP DMP ACETONE TONE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50 50 50
Early Deaths
Moribund Sacrifice 21 4 5 7 32 6
Natural Death 11 6 2 7 6 6
Accidently Killed 1
Survivors
Moribund Sacrifice 1
Terminal Sacrifice 18 38 40 35 10 38
Natural Death 1 2 1
Missing 1 1
Animals Examined Microscopically 50 50 49 50 49 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (46) (42)
Inflammation, Chronic 1 (2%) 1 (2%)
Intestine Large (49) (50)
Mucosa, Necrosis 1 (2%)
Intestine Large, Cecum (46) (46)
Amyloid Deposition 2 (4%) 1 (2%)
Edema 2 (4%) 1 (2%)
Intestine Large, Colon (45) (49)
Edema 2 (4%) 1 (2%)
Intestine Small (2) (49) (50) (1) (1)
Cortex, Amyloid Deposition 1 (2%)
Intestine Small, Duodenum (2) (48) (48) (1)
Amyloid Deposition 17 (35%) 16 (33%)
Inflammation, Subacute 1 (100%)
Intestine Small, Ileum (1) (48) (47) (1)
Amyloid Deposition 28 (58%) 29 (62%) 1 (100%)
Granuloma 1 (100%)
Hemorrhage 1 (2%)
Intestine Small, Jejunum (1) (48) (44)
Amyloid Deposition 20 (42%) 19 (43%)
Liver (10) (11) (49) (50) (8) (10)
Abscess 6 (60%) 2 (18%) 3 (6%) 5 (63%) 3 (30%)
Amyloid Deposition 3 (30%) 3 (27%) 16 (33%) 13 (26%) 2 (25%) 1 (10%)
Angiectasis 1 (13%)
Basophilic Focus 2 (4%)
Clear Cell Focus 1 (10%) 2 (18%)
Cyst 1 (9%)
Cyst Multilocular 1 (2%)
Eosinophilic Focus 1 (2%)
Hematopoietic Cell Proliferation 2 (20%) 3 (27%) 1 (2%) 9 (18%) 3 (38%) 5 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE ACETONE/ ACETONE/ ACETONE/ ACETONE/ DMBA/TPA DMBA/ACE
TPA DEP DMP ACETONE TONE
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hyperplasia 1 (2%)
Inflammation, Chronic, Focal 3 (27%) 28 (57%) 26 (52%) 1 (10%)
Karyomegaly 1 (2%) 1 (2%)
Necrosis 7 (70%) 3 (27%) 3 (6%) 4 (8%) 5 (63%)
Regeneration, Focal 1 (2%)
Vacuolization Cytoplasmic 2 (18%) 1 (2%) 1 (2%)
Vacuolization Nuclear 4 (8%)
Centrilobular, Cytomegaly 1 (2%)
Hepatocyte, Hyperplasia 2 (4%)
Mesentery (1) (2)
Abscess 1 (50%)
Necrosis 1 (100%)
Fat, Necrosis, Focal 1 (50%)
Pancreas (1) (49) (50) (1) (1)
Abscess 1 (100%)
Edema 1 (100%) 7 (14%) 4 (8%) 1 (100%)
Hypertrophy, Focal 1 (2%)
Inflammation, Subacute 1 (2%)
Salivary Glands (48) (50) (1)
Amyloid Deposition 16 (33%) 14 (28%)
Hemorrhage 1 (100%)
Necrosis 1 (100%)
Stomach (1) (48) (50)
Mucosa, Hyperplasia 2 (4%)
Mucosa, Hyperplasia, Glandular 1 (2%)
Stomach, Glandular (48) (50)
Amyloid Deposition 9 (19%) 7 (14%)
Dilatation 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Necrosis, Focal 1 (2%)
Mucosa, Dilatation 1 (2%)
Mucosa, Hyperplasia 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (3) (49) (50) (4) (4)
Abscess 1 (2%) 1 (2%) 1 (25%) 1 (25%)
Amyloid Deposition 3 (100%) 26 (53%) 26 (52%) 2 (50%)
Inflammation, Chronic, Focal 2 (4%) 3 (6%) 1 (25%)
Atrium, Thrombosis 2 (67%) 3 (6%) 1 (2%) 1 (25%) 2 (50%)
Epicardium, Inflammation, Suppurative 1 (25%) 1 (25%)
Ventricle, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE ACETONE/ ACETONE/ ACETONE/ ACETONE/ DMBA/TPA DMBA/ACE
TPA DEP DMP ACETONE TONE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (48) (50) (1)
Pigmentation 1 (2%)
Adrenal Gland, Amyloid Deposition 1 (2%)
Capsule, Hyperplasia 22 (46%) 21 (42%)
Adrenal Gland, Cortex (48) (50) (1)
Amyloid Deposition 21 (44%) 23 (46%)
Hyperplasia, Focal 1 (2%) 1 (2%)
Hypertrophy, Focal 1 (2%) 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Infiltration Cellular, Plasma Cell,
Lymphocyte 1 (2%)
Pigmentation 26 (54%) 21 (42%)
Adrenal Gland, Medulla (48) (50) (1)
Hematopoietic Cell Proliferation 1 (2%)
Parathyroid Gland (34) (11)
Amyloid Deposition 12 (35%) 2 (18%)
Pituitary Gland (48) (48)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia 1 (2%)
Pars Distalis, Hyperplasia, Focal 1 (2%) 1 (2%)
Pars Intermedia, Cyst 1 (2%)
Thyroid Gland (49) (46) (1)
Amyloid Deposition 24 (49%) 18 (39%) 1 (100%)
Follicle, Dilatation 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (3) (3) (3) (3) (3) (5)
Abscess 2 (67%) 2 (67%) 2 (67%) 1 (33%) 3 (100%) 2 (40%)
Granuloma 1 (33%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1)
Abscess 1 (100%)
Epididymis (49) (50) (1)
Cyst 1 (100%)
Inflammation, Subacute 1 (2%)
Spermatocele 1 (2%)
Penis (1) (2) (5) (1) (2)
Inflammation, Suppurative 1 (50%)
Preputial Gland (4) (2) (1) (1) (1)
Abscess 3 (75%) 1 (50%) 1 (100%)
Dilatation 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE ACETONE/ ACETONE/ ACETONE/ ACETONE/ DMBA/TPA DMBA/ACE
TPA DEP DMP ACETONE TONE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation 1 (100%)
Prostate (48) (47)
Abscess 1 (2%)
Hyperplasia 1 (2%)
Inflammation 1 (2%) 1 (2%)
Inflammation, Chronic 2 (4%)
Seminal Vesicle (9) (49) (50) (1) (5)
Dilatation 8 (89%) 6 (12%) 8 (16%) 4 (80%)
Fibrosis 1 (2%) 1 (20%)
Inflammation 1 (2%) 1 (2%)
Inflammation, Chronic 1 (100%)
Inflammation, Subacute 1 (11%)
Testes (49) (50)
Amyloid Deposition 11 (22%) 9 (18%)
Fibrosis 1 (2%)
Inflammation, Chronic 1 (2%)
Interstitial Cell, Hyperplasia 5 (10%) 3 (6%)
Seminiferous Tubule, Degeneration 21 (43%) 18 (36%)
Seminiferous Tubule, Giant Cell 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (24) (8) (49) (50) (35) (13)
Abscess 1 (3%)
Congestion 1 (13%)
Cyst 1 (3%)
Hematopoietic Cell Proliferation 1 (3%)
Hyperplasia 1 (4%) 2 (25%) 2 (4%) 4 (11%) 1 (8%)
Hyperplasia, Re Cell 1 (3%)
Axillary, Abscess 2 (6%)
Axillary, Cyst 2 (6%)
Axillary, Depletion Lymphoid 1 (3%)
Axillary, Hyperplasia 14 (58%) 1 (2%) 1 (2%) 27 (77%) 2 (15%)
Bronchial, Hyperplasia 1 (4%)
Iliac, Abscess 1 (13%)
Iliac, Hyperplasia 1 (13%)
Inguinal, Hyperplasia 2 (8%) 2 (6%)
Lumbar, Hyperplasia 1 (4%) 1 (3%)
Mediastinal, Abscess 1 (3%)
Mediastinal, Hyperplasia 2 (4%) 1 (3%) 1 (8%)
Pancreatic, Hyperplasia 1 (2%)
Renal, Abscess 1 (13%)
Renal, Hyperplasia 1 (3%) 1 (8%)
Lymph Node, Mandibular (17) (3) (48) (49) (23) (10)
Abscess 3 (18%) 2 (4%) 3 (30%)
Amyloid Deposition 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE ACETONE/ ACETONE/ ACETONE/ ACETONE/ DMBA/TPA DMBA/ACE
TPA DEP DMP ACETONE TONE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Cyst 1 (6%) 2 (4%) 2 (4%) 1 (4%)
Depletion Lymphoid 1 (4%)
Hematopoietic Cell Proliferation 2 (4%) 1 (4%)
Hyperplasia 15 (88%) 3 (100%) 6 (13%) 16 (33%) 21 (91%) 10 (100%)
Lymphocyte, Necrosis 1 (6%)
Lymph Node, Mesenteric (2) (3) (47) (43) (4) (3)
Abscess 1 (2%) 1 (2%)
Amyloid Deposition 11 (23%) 14 (33%)
Depletion Lymphoid 1 (33%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 2 (50%) 2 (67%)
Hemorrhage 1 (33%) 1 (2%)
Hyperplasia 1 (50%) 1 (33%) 2 (4%) 1 (2%) 2 (50%)
Hyperplasia, Re Cell 1 (33%)
Lymphocyte, Necrosis 1 (50%)
Spleen (28) (9) (49) (50) (42) (17)
Amyloid Deposition 7 (25%) 1 (11%) 8 (16%) 10 (20%) 9 (21%) 5 (29%)
Granuloma 1 (2%)
Hematopoietic Cell Proliferation 28 (100%) 9 (100%) 47 (96%) 48 (96%) 42 (100%) 16 (94%)
Pigmentation, Hemosiderin 2 (4%)
Thymus (1) (42) (43)
Cyst 1 (2%)
Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (49) (50) (49) (50)
Other, Abscess 3 (6%) 2 (4%) 2 (4%) 2 (4%) 4 (8%) 5 (10%)
Other, Acanthosis 25 (50%) 11 (22%) 7 (14%) 15 (30%) 26 (53%) 15 (30%)
Other, Acanthosis, Focal 1 (2%)
Other, Edema 2 (4%) 3 (6%) 1 (2%) 1 (2%) 1 (2%)
Other, Exudate 17 (34%) 4 (8%) 5 (10%) 14 (28%) 22 (45%) 12 (24%)
Other, Hyperkeratosis 16 (32%) 5 (10%) 2 (4%) 7 (14%) 19 (39%) 8 (16%)
Other, Inflammation, Subacute 24 (48%) 11 (22%) 8 (16%) 15 (30%) 25 (51%) 14 (28%)
Other, Ulcer 26 (52%) 9 (18%) 8 (16%) 16 (32%) 26 (53%) 15 (30%)
Sebaceous Gland, Site of Application-Mass,
Hyperplasia 1 (2%)
Site of Application-Mass, Abscess 2 (4%)
Site of Application-Mass, Acanthosis 1 (2%)
Site of Application-Mass, Acanthosis, Focal 1 (2%) 1 (2%) 1 (2%) 11 (22%) 2 (4%)
Site of Application-Mass, Exudate 1 (2%)
Site of Application-Mass, Hyperkeratosis,
Focal 1 (2%)
Site of Application-Mass, Hyperplasia, Focal,
Mast Cell 1 (2%)
Site of Application-Mass, Inflammation,
Subacute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE ACETONE/ ACETONE/ ACETONE/ ACETONE/ DMBA/TPA DMBA/ACE
TPA DEP DMP ACETONE TONE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Site of Application-Mass, Inflammation,
Suppurative 1 (2%)
Skin, Control (50) (50) (49) (50) (49) (50)
Acanthosis 1 (2%) 1 (2%) 1 (2%)
Edema 1 (2%)
Exudate 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Subacute 1 (2%) 2 (4%) 1 (2%) 2 (4%)
Ulcer 1 (2%)
Skin, Site of Application-No Mass (50) (50) (49) (50) (49) (50)
Abscess 2 (4%)
Acanthosis 47 (94%) 9 (18%) 11 (22%) 8 (16%) 45 (92%) 18 (36%)
Cyst Epithelial Inclusion 1 (2%) 1 (2%)
Edema 1 (2%)
Exudate 25 (50%) 8 (16%) 7 (14%) 4 (8%) 31 (63%) 10 (20%)
Hyperkeratosis 34 (68%) 6 (12%) 4 (8%) 1 (2%) 39 (80%) 13 (26%)
Inflammation, Subacute 30 (60%) 4 (8%) 7 (14%) 9 (18%) 34 (69%) 8 (16%)
Ulcer 23 (46%) 5 (10%) 6 (12%) 2 (4%) 22 (45%) 7 (14%)
Sebaceous Gland, Hyperplasia, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (49)
Thalamus, Mineralization, Focal 1 (2%) 9 (18%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (49) (50) (49) (50)
Abscess 1 (2%) 2 (4%) 1 (2%)
Amyloid Deposition 1 (2%) 1 (2%)
Atelectasis 1 (2%)
Congestion 3 (6%) 1 (2%) 5 (10%) 3 (6%) 1 (2%) 1 (2%)
Hemorrhage 3 (6%) 1 (2%) 2 (4%)
Inflammation, Chronic, Focal 2 (4%) 1 (2%)
Leukocytosis 10 (20%) 2 (4%) 6 (12%) 12 (24%) 7 (14%)
Alveolar Epithelium, Hyperplasia 1 (2%) 2 (4%) 4 (8%) 2 (4%) 1 (2%) 3 (6%)
Alveolar Epithelium, Metaplasia, Focal,
Squamous 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 4 (8%) 2 (4%) 4 (8%) 4 (8%) 8 (16%) 3 (6%)
Bronchiole, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE ACETONE/ ACETONE/ ACETONE/ ACETONE/ DMBA/TPA DMBA/ACE
TPA DEP DMP ACETONE TONE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Bronchiole, Inflammation, Suppurative 1 (2%)
Bronchiole, Inflammation, Proliferative 1 (2%)
Bronchiole, Metaplasia 1 (2%)
Interstitium, Inflammation 9 (18%) 5 (10%) 4 (8%) 9 (18%) 13 (27%) 8 (16%)
Interstitium, Inflammation, Chronic, Focal 9 (18%) 9 (18%) 6 (12%) 4 (8%) 4 (8%)
Pleura, Fibrosis, Focal 1 (2%)
Pleura, Inflammation, Suppurative 1 (2%) 2 (4%)
Nose (49) (50)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (1) (2) (3) (1)
Cataract 1 (33%)
Inflammation, Suppurative 1 (25%) 1 (33%)
Cornea, Hyperplasia, Chronic 1 (25%)
Cornea, Hyperplasia, Focal 1 (25%)
Cornea, Inflammation, Chronic 1 (25%) 2 (100%) 1 (33%) 1 (100%)
Retrobulbar, Inflammation, Subacute 1 (33%)
Harderian Gland (1)
Inflammation, Chronic 1 (100%)
Zymbal's Gland (1)
Dilatation 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (6) (5) (49) (50) (7) (5)
Abscess 1 (17%) 1 (20%) 1 (2%) 3 (6%) 2 (29%) 1 (20%)
Amyloid Deposition 3 (50%) 4 (80%) 23 (47%) 27 (54%) 2 (40%)
Hematopoietic Cell Proliferation 1 (17%) 1 (20%)
Infarct 1 (2%)
Infiltration Cellular, Focal, Plasma Cell 1 (14%)
Infiltration Cellular, Plasma Cell 3 (6%) 1 (20%)
Infiltration Cellular, Lymphocyte 1 (20%)
Nephropathy 15 (31%) 14 (28%) 1 (14%) 1 (20%)
Cortex, Atrophy 2 (33%) 2 (29%) 1 (20%)
Cortex, Cyst 9 (18%) 5 (10%)
Papilla, Necrosis 1 (14%)
Pelvis, Dilatation 2 (33%) 3 (60%) 13 (27%) 11 (22%) 2 (40%)
Proximal Convoluted Renal Tubule,
Vacuolization Cytoplasmic 1 (14%)
Urinary Bladder (1) (3) (46) (47)
Calculus Micro Observation Only 6 (13%)
Inflammation 1 (2%)
Inflammation, Chronic 1 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE ACETONE/ ACETONE/ ACETONE/ ACETONE/ DMBA/TPA DMBA/ACE
TPA DEP DMP ACETONE TONE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Mucosa, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE DMBA/DEP DMBA/DMP DEP/TPA DEP/ACET DMP/TPA DMP/ACET
ONE ONE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50 50 50
Early Deaths
Moribund Sacrifice 3 4 31 10 27 5
Natural Death 4 7 4 4 9 5
Accidently Killed 1
Survivors
Terminal Sacrifice 42 36 14 35 13 38
Natural Death 1 3 1 1
Missing 1 1
Animals Examined Microscopically 50 50 49 50 49 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (2)
Edema 2 (100%)
Inflammation, Chronic 1 (50%)
Necrosis 1 (50%)
Intestine Small, Duodenum (1)
Amyloid Deposition 1 (100%)
Intestine Small, Ileum (1) (3)
Amyloid Deposition 2 (67%)
Granuloma 1 (100%)
Intestine Small, Jejunum (2) (1)
Amyloid Deposition 1 (50%) 1 (100%)
Liver (8) (6) (7) (9) (10) (14)
Abscess 1 (17%) 5 (71%) 1 (11%) 3 (30%) 1 (7%)
Amyloid Deposition 1 (13%) 1 (17%) 1 (14%) 2 (22%) 3 (30%) 5 (36%)
Basophilic Focus 1 (13%)
Clear Cell Focus, Multiple 1 (17%)
Cytomegaly 1 (17%)
Hematopoietic Cell Proliferation 2 (25%) 4 (57%) 2 (20%) 3 (21%)
Inflammation, Chronic, Focal 1 (13%) 4 (67%) 1 (14%) 3 (33%) 2 (20%) 6 (43%)
Necrosis 1 (13%) 3 (43%) 1 (11%) 2 (20%) 1 (7%)
Necrosis, Focal 1 (10%)
Vacuolization Cytoplasmic 1 (13%) 1 (11%)
Centrilobular, Cytomegaly 1 (13%)
Mesentery (1) (1)
Inflammation, Chronic 1 (100%)
Fat, Necrosis, Focal 1 (100%)
Pancreas (1) (3) (1) (1)
Edema 1 (100%) 3 (100%) 1 (100%)
Tongue (1)
Abscess 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE DMBA/DEP DMBA/DMP DEP/TPA DEP/ACET DMP/TPA DMP/ACET
ONE ONE
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (3) (2) (1) (1)
Abscess 1 (50%) 1 (100%)
Amyloid Deposition 3 (100%) 1 (50%) 1 (100%)
Atrium, Thrombosis 2 (67%) 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Pituitary Gland (1)
Cyst 1 (100%)
Thyroid Gland (1) (1)
Amyloid Deposition 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (4) (4) (1) (6) (2) (4)
Abscess 1 (100%) 1 (17%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (1)
Inflammation 1 (100%)
Spermatocele 1 (100%)
Penis (1) (1) (3) (1) (3) (2)
Abscess 2 (67%)
Edema 1 (100%) 1 (50%)
Preputial Gland (2) (1) (2) (2) (2) (2)
Abscess 1 (50%) 1 (100%) 2 (100%) 1 (50%) 2 (100%) 1 (50%)
Dilatation 1 (50%) 1 (100%) 1 (50%) 1 (50%)
Inflammation, Chronic 1 (50%)
Prostate (1)
Hemorrhage 1 (100%)
Seminal Vesicle (6) (3) (4) (6) (7)
Abscess 1 (25%)
Dilatation 6 (100%) 3 (100%) 3 (75%) 5 (83%) 6 (86%)
Fibrosis 1 (17%)
Inflammation 2 (33%)
Testes (2) (1) (1) (1)
Amyloid Deposition 1 (100%)
Seminiferous Tubule, Atrophy 2 (100%) 1 (100%)
Tunic, Fibrosis 1 (100%)
Tunic, Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE DMBA/DEP DMBA/DMP DEP/TPA DEP/ACET DMP/TPA DMP/ACET
ONE ONE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (6) (2) (35) (18) (29) (8)
Abscess 1 (6%) 1 (3%)
Cyst 1 (3%) 1 (6%)
Hematopoietic Cell Proliferation 1 (50%)
Hyperplasia 5 (14%) 1 (6%) 5 (17%) 2 (25%)
Axillary, Hematopoietic Cell Proliferation 1 (3%)
Axillary, Hyperplasia 1 (50%) 19 (54%) 4 (22%) 21 (72%)
Axillary, Hyperplasia, Focal, Lymphoid 1 (3%)
Axillary, Hyperplasia, Plasma Cell 1 (3%)
Inguinal, Hyperplasia 2 (7%)
Mediastinal, Hyperplasia 1 (3%)
Pancreatic, Hematopoietic Cell Proliferation 1 (50%)
Lymph Node, Mandibular (4) (1) (22) (16) (22) (6)
Abscess 2 (50%) 2 (9%) 1 (6%) 3 (14%)
Amyloid Deposition 1 (5%)
Cyst 1 (100%) 1 (17%)
Hematopoietic Cell Proliferation 1 (25%) 2 (9%)
Hyperplasia 2 (50%) 1 (100%) 18 (82%) 14 (88%) 22 (100%) 5 (83%)
Hyperplasia, Plasma Cell 2 (9%) 1 (5%)
Lymphatic, Dilatation 1 (6%)
Lymph Node, Mesenteric (2) (1) (5) (2) (1) (1)
Amyloid Deposition 1 (50%)
Cyst 1 (100%)
Hematopoietic Cell Proliferation 4 (80%) 1 (50%) 1 (100%)
Hemorrhage 1 (50%) 1 (100%)
Hyperplasia 1 (20%) 1 (50%) 1 (100%)
Infarct 1 (50%)
Spleen (7) (4) (32) (13) (34) (7)
Amyloid Deposition 2 (29%) 3 (9%) 2 (15%) 9 (26%) 1 (14%)
Congestion 1 (14%)
Hematopoietic Cell Proliferation 7 (100%) 4 (100%) 32 (100%) 12 (92%) 33 (97%) 7 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (49) (50) (49) (50)
Amyloid Deposition 1 (2%)
Other, Abscess 1 (2%) 4 (8%) 1 (2%) 2 (4%) 2 (4%)
Other, Acanthosis 5 (10%) 4 (8%) 27 (55%) 18 (36%) 21 (43%) 11 (22%)
Other, Edema 2 (4%) 5 (10%) 4 (8%) 4 (8%)
Other, Exudate 3 (6%) 4 (8%) 23 (47%) 14 (28%) 13 (27%) 9 (18%)
Other, Hyperkeratosis 1 (2%) 1 (2%) 18 (37%) 6 (12%) 11 (22%) 4 (8%)
Other, Inflammation, Subacute 5 (10%) 4 (8%) 25 (51%) 16 (32%) 19 (39%) 8 (16%)
Other, Ulcer 5 (10%) 3 (6%) 26 (53%) 18 (36%) 20 (41%) 12 (24%)
Sebaceous Gland, Site of Application-Mass,
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE DMBA/DEP DMBA/DMP DEP/TPA DEP/ACET DMP/TPA DMP/ACET
ONE ONE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Hyperplasia 1 (2%)
Site of Application-Mass, Acanthosis 1 (2%)
Site of Application-Mass, Acanthosis, Focal 1 (2%) 1 (2%)
Subcutaneous Tissue, Other, Exudate, Focal 1 (2%)
Skin, Control (50) (50) (49) (50) (49) (50)
Acanthosis 1 (2%) 1 (2%)
Edema 3 (6%) 1 (2%) 1 (2%)
Exudate 1 (2%) 1 (2%)
Hyperkeratosis 2 (4%)
Inflammation, Subacute 1 (2%) 2 (4%) 2 (4%)
Ulcer 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Skin, Site of Application-No Mass (50) (50) (49) (49) (49) (50)
Abscess 2 (4%)
Acanthosis 6 (12%) 7 (14%) 42 (86%) 14 (29%) 47 (96%) 9 (18%)
Edema 1 (2%)
Exudate 5 (10%) 2 (4%) 32 (65%) 11 (22%) 30 (61%) 5 (10%)
Hyperkeratosis 5 (10%) 2 (4%) 31 (63%) 8 (16%) 34 (69%) 1 (2%)
Hyperplasia, Focal, Mast Cell 1 (2%)
Inflammation, Subacute 4 (8%) 3 (6%) 37 (76%) 7 (14%) 38 (78%) 3 (6%)
Ulcer 5 (10%) 3 (6%) 25 (51%) 6 (12%) 27 (55%) 3 (6%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (48) (50) (49) (50)
Abscess 1 (2%) 1 (2%) 1 (2%)
Atelectasis 1 (2%) 1 (2%)
Congestion 2 (4%) 6 (12%) 2 (4%) 1 (2%) 2 (4%) 4 (8%)
Fibrosis, Focal 1 (2%) 1 (2%)
Foreign Body 1 (2%)
Granuloma 1 (2%)
Hemorrhage 3 (6%) 9 (18%) 5 (10%) 1 (2%) 3 (6%)
Inflammation, Chronic, Focal 1 (2%)
Leukocytosis 2 (4%) 6 (13%) 6 (12%) 5 (10%) 2 (4%)
Alveolar Epithelium, Hyperplasia 2 (4%) 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Alveolus, Infiltration Cellular, Histiocyte 3 (6%) 5 (10%) 4 (8%) 8 (16%) 3 (6%) 4 (8%)
Interstitium, Inflammation 5 (10%) 11 (22%) 8 (17%) 10 (20%) 2 (4%) 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE DMBA/DEP DMBA/DMP DEP/TPA DEP/ACET DMP/TPA DMP/ACET
ONE ONE
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Interstitium, Inflammation, Chronic, Focal 11 (22%) 7 (14%) 5 (10%) 8 (16%) 1 (2%) 8 (16%)
Pleura, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (1) (2) (5) (2)
Cornea, Hyperplasia 1 (20%)
Cornea, Inflammation, Chronic 1 (100%) 2 (100%) 2 (40%) 1 (50%)
Cornea, Inflammation, Subacute 1 (50%)
Lids, Inflammation, Chronic 1 (100%)
Lids, Cornea, Inflammation, Subacute 1 (20%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (7) (10) (6) (5) (4) (8)
Abscess 1 (25%) 1 (13%)
Amyloid Deposition 5 (71%) 7 (70%) 3 (50%) 4 (80%) 2 (50%) 5 (63%)
Infarct 1 (10%)
Nephropathy 1 (10%)
Cortex, Atrophy 1 (17%) 2 (40%) 1 (25%)
Cortex, Cyst 1 (14%) 3 (30%) 1 (17%) 1 (20%)
Cortex, Infiltration Cellular, Plasma Cell 1 (25%)
Papilla, Mineralization 1 (25%)
Papilla, Necrosis 1 (25%)
Pelvis, Dilatation 4 (57%) 4 (40%) 2 (33%) 2 (40%) 1 (25%) 4 (50%)
Proximal Convoluted Renal Tubule, Necrosis 1 (25%)
Proximal Convoluted Renal Tubule,
Vacuolization Cytoplasmic 1 (20%) 1 (25%)
Urethra (1) (1)
Inflammation, Acute 1 (100%)
Urinary Bladder (1) (2) (6) (1) (3)
Amyloid Deposition 1 (17%)
Calculus Micro Observation Only 1 (33%)
Congestion 1 (33%)
Hemorrhage 1 (50%) 1 (17%)
Submucosa, Hemorrhage 1 (17%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
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