TDMS Study 05119-01 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
DIETHYLPHTHALATE/DIMETHYLPHTHALATE
NTP Experiment-Test: 05119-01 Report: PEIRPT05
Study Type: INIT/PROMOT Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
Facility: Hazleton, Maryland
Chemical CAS #: 84-66-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE ACETONE/ ACETONE/ ACETONE/ ACETONE/ DMBA/TPA DMBA/ACE
TPA DEP DMP ACETONE TONE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50 50 50
Early Deaths
Moribund Sacrifice 21 4 5 7 32 6
Natural Death 11 6 2 7 6 6
Accidently Killed 1
Survivors
Moribund Sacrifice 1
Terminal Sacrifice 18 38 40 35 10 38
Natural Death 1 2 1
Missing 1 1
Animals Examined Microscopically 50 50 49 50 49 50
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ALIMENTARY SYSTEM
Intestine Small, Jejunum (1) (48) (44)
Adenocarcinoma 1 (2%)
Liver (10) (11) (49) (50) (8) (10)
Hemangiosarcoma 1 (2%)
Hemangiosarcoma, Multiple 1 (10%)
Hepatocellular Carcinoma 1 (9%) 2 (4%)
Hepatocellular Adenoma 1 (10%) 3 (27%) 9 (18%) 5 (10%) 3 (30%)
Hepatocellular Adenoma, Multiple 1 (2%)
Hepatocholangiocarcinoma 1 (9%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Gland, Cortex (48) (50) (1)
Adenoma 2 (4%) 4 (8%)
Carcinoma 1 (2%)
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GENERAL BODY SYSTEM
Tissue NOS (3) (3) (3) (3) (3) (5)
Lipoma 1 (33%) 1 (33%) 1 (33%) 1 (33%) 3 (60%)
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NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE ACETONE/ ACETONE/ ACETONE/ ACETONE/ DMBA/TPA DMBA/ACE
TPA DEP DMP ACETONE TONE
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (24) (8) (49) (50) (35) (13)
Bronchial, Alveolar/Bronchiolar Carcinoma,
Metastatic 1 (8%)
Thymus (1) (42) (43)
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INTEGUMENTARY SYSTEM
Skin (50) (50) (49) (50) (49) (50)
Other, Hemangioma 1 (2%)
Other, Squamous Cell Carcinoma 1 (2%)
Sebaceous Gland, Site of Application-Mass,
Adenoma 1 (2%)
Site of Application-Mass, Papilloma 4 (8%) 3 (6%) 1 (2%)
Site of Application-Mass, Papilloma, Multiple 1 (2%) 20 (41%)
Site of Application-Mass, Squamous Cell
Carcinoma 7 (14%) 2 (4%)
Skin, Site of Application-No Mass (50) (50) (49) (50) (49) (50)
Squamous Cell Carcinoma 2 (4%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (50) (50) (49) (50) (49) (50)
Alveolar/Bronchiolar Adenoma 4 (8%) 6 (12%) 4 (8%) 3 (6%) 5 (10%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%)
Squamous Cell Carcinoma, Metastatic 1 (2%)
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NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE ACETONE/ ACETONE/ ACETONE/ ACETONE/ DMBA/TPA DMBA/ACE
TPA DEP DMP ACETONE TONE
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (6) (5) (49) (50) (7) (5)
Urinary Bladder (1) (3) (46) (47)
Carcinoma 1 (2%)
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SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(49) *(50) *(49) *(50)
Lymphoma Malignant Lymphocytic 2 (4%)
Lymphoma Malignant Mixed 1 (2%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE ACETONE/ ACETONE/ ACETONE/ ACETONE/ DMBA/TPA DMBA/ACE
TPA DEP DMP ACETONE TONE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 11 15 19 14 25 16
Total Primary Neoplasms 12 17 23 16 34 18
Total Animals with Benign Neoplasms 10 10 15 12 23 13
Total Benign Neoplasms 11 11 18 14 23 13
Total Animals with Malignant Neoplasms 1 6 5 2 9 4
Total Malignant Neoplasms 1 6 5 2 11 5
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 1 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE DMBA/DEP DMBA/DMP DEP/TPA DEP/ACET DMP/TPA DMP/ACET
ONE ONE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50 50 50
Early Deaths
Moribund Sacrifice 3 4 31 10 27 5
Natural Death 4 7 4 4 9 5
Accidently Killed 1
Survivors
Terminal Sacrifice 42 36 14 35 13 38
Natural Death 1 3 1 1
Missing 1 1
Animals Examined Microscopically 50 50 49 50 49 50
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ALIMENTARY SYSTEM
Liver (8) (6) (7) (9) (10) (14)
Hepatocellular Carcinoma 1 (13%) 1 (7%)
Hepatocellular Carcinoma, Multiple 1 (11%)
Hepatocellular Adenoma 2 (25%) 2 (33%) 1 (14%) 5 (56%) 1 (10%) 4 (29%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (4) (4) (1) (6) (2) (4)
Hemangioma 1 (50%)
Lipoma 4 (100%) 4 (100%) 5 (83%) 1 (50%) 4 (100%)
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GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE DMBA/DEP DMBA/DMP DEP/TPA DEP/ACET DMP/TPA DMP/ACET
ONE ONE
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (7) (4) (32) (13) (34) (7)
Thymus (1)
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INTEGUMENTARY SYSTEM
Skin (50) (50) (49) (50) (49) (50)
Other, Papilloma 1 (2%)
Site of Application-Mass, Papilloma 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Site of Application-Mass, Papilloma, Multiple 1 (2%) 1 (2%) 1 (2%)
Site of Application-Mass, Squamous Cell
Carcinoma 1 (2%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (48) (50) (49) (50)
Alveolar/Bronchiolar Adenoma 5 (10%) 5 (10%) 1 (2%) 2 (4%) 3 (6%)
Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) 2 (4%) 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
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SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(49) *(50) *(49) *(50)
Lymphoma Malignant Lymphocytic 1 (2%)
* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE DMBA/DEP DMBA/DMP DEP/TPA DEP/ACET DMP/TPA DMP/ACET
ONE ONE
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(49) *(50) *(49) *(50)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05119-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 05/20/95
Route: SKIN APPLICATION Time: 02:35:33
____________________________________________________________________________________________________________________________________
CD-1 CRL MICE OUTBRED CHARLES RIVE MALE DMBA/DEP DMBA/DMP DEP/TPA DEP/ACET DMP/TPA DMP/ACET
ONE ONE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 13 11 6 11 7 13
Total Primary Neoplasms 14 12 7 17 7 13
Total Animals with Benign Neoplasms 13 11 6 9 6 12
Total Benign Neoplasms 13 12 6 15 6 12
Total Animals with Malignant Neoplasms 1 1 2 1 1
Total Malignant Neoplasms 1 1 2 1 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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