TDMS Study 05119-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Hazelton, MD DIETHYLPHTHALATE/DIMETHYLPHTHALATE DATE: 05/20/95
EXPERIMENT: 05119 TEST: 01 TIME: 02:44:25
TEST TYPE: INIT/PROMOT CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1ES45036 ROUTE: SKIN APPLICATION NTP C#: 10112F
PATHOLOGIST: R. CARDY CAS: 84-66-2
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Hazelton, MD DIETHYLPHTHALATE/DIMETHYLPHTHALATE DATE: 05/20/95
EXPERIMENT: 05119 TEST: 01 TIME: 02:44:25
TEST TYPE: INIT/PROMOT CAGES FROM 0000 TO LAST CAGE
CONT: NO1ES45036 ROUTE: SKIN APPLICATION NTP C#: 10112F
PATHOLOGIST: R. CARDY CAS: 84-66-2
CD(1 CRL MICE OUTBRED CHARLES RIVER)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Gland
Bone Marrow
Brain
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Hazelton, MD DIETHYLPHTHALATE/DIMETHYLPHTHALATE DATE: 05/20/95
EXPERIMENT: 05119 TEST: 01 TIME: 02:44:25
TEST TYPE: INIT/PROMOT CAGES FROM 0000 TO LAST CAGE
CONT: NO1ES45036 ROUTE: SKIN APPLICATION NTP C#: 10112F
PATHOLOGIST: R. CARDY CAS: 84-66-2
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF DIETHYLPHTHALATE/DIMETHYLPHTHALATE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Skin Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal
Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma
Papilloma
Squamous Cell Carcinoma
Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma
Tissue NOS Lipoma
All Organs Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 05/20/95 EXPERIMENT: 05119 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE CD(1 CRL MICE OUTBRED CHARLES RIVER) -- DIETHYLPHTHALATE/DIMETHYLPHTHALATE
TERMINAL SACRIFICE AT 56 WEEKS
|==============================================================================|
|DOSE | ACETONE/ DMBA/DMP DMP/ACET |
| | ACETONE ONE |
|==============================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 6/98 (6%) 0/1 (0%) 0/0 (0%) |
|ADJUSTED (b) | 7.8% 0.0% 0.0% |
|TERMINAL (d) | 6/77 (8%) 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 387 (T) --- --- |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | (e) (e) (e) |
|INCIDENTAL TUMOR | (e) (e) (e) |
|LOGISTIC REGRESSION | (e) (e) (e) |
|COCHRAN-ARMITAGE | P=1.000N |
|FISHER EXACT | P=0.939N P=1.000N |
|==============================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 19/120 (16%) 7/32 (22%) 11/40 (28%) |
|ADJUSTED (b) | 21.6% 41.2% 53.8% |
|TERMINAL (d) | 19/88 (22%) 7/17 (41%) 9/17 (53%) |
|FIRST INCIDENCE (DAYS) | 387 (T) 387 (T) 368 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.003 ** P=0.081 P=0.003 ** |
|INCIDENTAL TUMOR | P=0.003 ** P=0.081 P=0.001 ** |
|LOGISTIC REGRESSION | P=0.004 ** P=0.081 P=0.002 ** |
|COCHRAN-ARMITAGE | P=0.104 |
|FISHER EXACT | P=0.286 P=0.083 |
|==============================================================================|
DATE: 05/20/95 EXPERIMENT: 05119 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE CD(1 CRL MICE OUTBRED CHARLES RIVER) -- DIETHYLPHTHALATE/DIMETHYLPHTHALATE
TERMINAL SACRIFICE AT 56 WEEKS
|==============================================================================|
|DOSE | ACETONE/ DMBA/DMP DMP/ACET |
| | ACETONE ONE |
|==============================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 3/120 (3%) 1/32 (3%) 2/40 (5%) |
|ADJUSTED (b) | 3.4% 5.9% 11.8% |
|TERMINAL (d) | 3/88 (3%) 1/17 (6%) 2/17 (12%) |
|FIRST INCIDENCE (DAYS) | 387 (T) 387 (T) 387 (T) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.212 P=0.581 P=0.196 |
|INCIDENTAL TUMOR | P=0.212 P=0.581 P=0.196 |
|LOGISTIC REGRESSION | P=0.212 P=0.581 P=0.196 |
|COCHRAN-ARMITAGE | P=0.399 |
|FISHER EXACT | P=0.616 P=0.367 |
|==============================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 22/120 (18%) 8/32 (25%) 13/40 (33%) |
|ADJUSTED (b) | 25.0% 47.1% 65.4% |
|TERMINAL (d) | 22/88 (25%) 8/17 (47%) 11/17 (65%) |
|FIRST INCIDENCE (DAYS) | 387 (T) 387 (T) 368 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P=0.061 P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.061 P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.061 P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.066 |
|FISHER EXACT | P=0.271 P=0.052 |
|==============================================================================|
DATE: 05/20/95 EXPERIMENT: 05119 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE CD(1 CRL MICE OUTBRED CHARLES RIVER) -- DIETHYLPHTHALATE/DIMETHYLPHTHALATE
TERMINAL SACRIFICE AT 56 WEEKS
|==============================================================================|
|DOSE | ACETONE/ DMBA/DMP DMP/ACET |
| | ACETONE ONE |
|==============================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 22/120 (18%) 8/32 (25%) 13/40 (33%) |
|ADJUSTED (b) | 25.0% 47.1% 65.4% |
|TERMINAL (d) | 22/88 (25%) 8/17 (47%) 11/17 (65%) |
|FIRST INCIDENCE (DAYS) | 387 (T) 387 (T) 368 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P<0.001 ** P=0.061 P<0.001 ** |
|INCIDENTAL TUMOR | P<0.001 ** P=0.061 P<0.001 ** |
|LOGISTIC REGRESSION | P<0.001 ** P=0.061 P<0.001 ** |
|COCHRAN-ARMITAGE | P=0.066 |
|FISHER EXACT | P=0.271 P=0.052 |
|==============================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 19/199 (10%) 15/199 (8%) 10/197 (5%) |
|ADJUSTED (b) | 14.0% 10.9% 9.9% |
|TERMINAL (d) | 18/135 (13%) 11/131 (8%) 10/101 (10%) |
|FIRST INCIDENCE (DAYS) | 380 330 387 (T) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.278N P=0.328N P=0.222N |
|INCIDENTAL TUMOR | P=0.225N P=0.329N P=0.225N |
|LOGISTIC REGRESSION | P=0.228N P=0.331N P=0.198N |
|COCHRAN-ARMITAGE | P=0.088N |
|FISHER EXACT | P=0.296N P=0.064N |
|==============================================================================|
DATE: 05/20/95 EXPERIMENT: 05119 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE CD(1 CRL MICE OUTBRED CHARLES RIVER) -- DIETHYLPHTHALATE/DIMETHYLPHTHALATE
TERMINAL SACRIFICE AT 56 WEEKS
|==============================================================================|
|DOSE | ACETONE/ DMBA/DMP DMP/ACET |
| | ACETONE ONE |
|==============================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 4/199 (2%) 2/199 (1%) 1/197 (1%) |
|ADJUSTED (b) | 2.9% 1.5% 1.0% |
|TERMINAL (d) | 3/135 (2%) 2/131 (2%) 1/101 (1%) |
|FIRST INCIDENCE (DAYS) | 338 387 (T) 387 (T) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.353N P=0.354N P=0.275N |
|INCIDENTAL TUMOR | P=0.309N P=0.341N P=0.220N |
|LOGISTIC REGRESSION | P=0.324N P=0.355N P=0.247N |
|COCHRAN-ARMITAGE | P=0.254N |
|FISHER EXACT | P=0.343N P=0.189N |
|==============================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 22/199 (11%) 17/199 (9%) 11/197 (6%) |
|ADJUSTED (b) | 16.0% 12.4% 10.9% |
|TERMINAL (d) | 20/135 (15%) 13/131 (10%) 11/101 (11%) |
|FIRST INCIDENCE (DAYS) | 338 330 387 (T) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.218N P=0.282N P=0.159N |
|INCIDENTAL TUMOR | P=0.163N P=0.278N P=0.145N |
|LOGISTIC REGRESSION | P=0.169N P=0.285N P=0.132N |
|COCHRAN-ARMITAGE | P=0.056N |
|FISHER EXACT | P=0.250N P=0.036N* |
|==============================================================================|
DATE: 05/20/95 EXPERIMENT: 05119 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE CD(1 CRL MICE OUTBRED CHARLES RIVER) -- DIETHYLPHTHALATE/DIMETHYLPHTHALATE
TERMINAL SACRIFICE AT 56 WEEKS
|==============================================================================|
|DOSE | ACETONE/ DMBA/DMP DMP/ACET |
| | ACETONE ONE |
|==============================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal |
| Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoep|thelioma
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 5/199 (3%) 31/199 (16%) 8/198 (4%) |
|ADJUSTED (b) | 3.6% 19.7% 7.6% |
|TERMINAL (d) | 4/135 (3%) 15/131 (11%) 7/102 (7%) |
|FIRST INCIDENCE (DAYS) | 323 141 348 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.081N P<0.001 ** P=0.144 |
|INCIDENTAL TUMOR | P=0.014N* P<0.001 ** P=0.195 |
|LOGISTIC REGRESSION | P=0.019N* P<0.001 ** P=0.173 |
|COCHRAN-ARMITAGE | P=0.021N* |
|FISHER EXACT | P<0.001 ** P=0.284 |
|==============================================================================|
| |
|Skin |
| Papilloma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 5/199 (3%) 27/199 (14%) 7/198 (4%) |
|ADJUSTED (b) | 3.6% 17.3% 6.6% |
|TERMINAL (d) | 4/135 (3%) 13/131 (10%) 6/102 (6%) |
|FIRST INCIDENCE (DAYS) | 323 141 348 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.092N P<0.001 ** P=0.221 |
|INCIDENTAL TUMOR | P=0.020N* P<0.001 ** P=0.290 |
|LOGISTIC REGRESSION | P=0.028N* P<0.001 ** P=0.259 |
|COCHRAN-ARMITAGE | P=0.028N* |
|FISHER EXACT | P<0.001 ** P=0.382 |
|==============================================================================|
DATE: 05/20/95 EXPERIMENT: 05119 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE CD(1 CRL MICE OUTBRED CHARLES RIVER) -- DIETHYLPHTHALATE/DIMETHYLPHTHALATE
TERMINAL SACRIFICE AT 56 WEEKS
|==============================================================================|
|DOSE | ACETONE/ DMBA/DMP DMP/ACET |
| | ACETONE ONE |
|==============================================================================|
| |
|Skin |
| Squamous Cell Carcinoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 0/199 (0%) 11/199 (6%) 1/198 (1%) |
|ADJUSTED (b) | 0.0% 7.4% 1.0% |
|TERMINAL (d) | 0/135 (0%) 5/131 (4%) 1/102 (1%) |
|FIRST INCIDENCE (DAYS) | --- 259 387 (T) |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.107N P=0.001 ** P=0.444 |
|INCIDENTAL TUMOR | P=0.041N* P=0.002 ** P=0.444 |
|LOGISTIC REGRESSION | P=0.058N P=0.001 ** P=0.444 |
|COCHRAN-ARMITAGE | P=0.062N |
|FISHER EXACT | P<0.001 ** P=0.499 |
|==============================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacan|homa
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 5/199 (3%) 31/199 (16%) 8/198 (4%) |
|ADJUSTED (b) | 3.6% 19.7% 7.6% |
|TERMINAL (d) | 4/135 (3%) 15/131 (11%) 7/102 (7%) |
|FIRST INCIDENCE (DAYS) | 323 141 348 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.081N P<0.001 ** P=0.144 |
|INCIDENTAL TUMOR | P=0.014N* P<0.001 ** P=0.195 |
|LOGISTIC REGRESSION | P=0.019N* P<0.001 ** P=0.173 |
|COCHRAN-ARMITAGE | P=0.021N* |
|FISHER EXACT | P<0.001 ** P=0.284 |
|==============================================================================|
DATE: 05/20/95 EXPERIMENT: 05119 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE CD(1 CRL MICE OUTBRED CHARLES RIVER) -- DIETHYLPHTHALATE/DIMETHYLPHTHALATE
TERMINAL SACRIFICE AT 56 WEEKS
|==============================================================================|
|DOSE | ACETONE/ DMBA/DMP DMP/ACET |
| | ACETONE ONE |
|==============================================================================|
| |
|Tissue NOS |
| Lipoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 4/199 (2%) 11/199 (6%) 10/198 (5%) |
|ADJUSTED (b) | 3.0% 8.4% 9.6% |
|TERMINAL (d) | 4/135 (3%) 11/131 (8%) 9/102 (9%) |
|FIRST INCIDENCE (DAYS) | 387 (T) 387 (T) 357 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.119 P=0.049 * P=0.028 * |
|INCIDENTAL TUMOR | P=0.135 P=0.049 * P=0.035 * |
|LOGISTIC REGRESSION | P=0.140 P=0.049 * P=0.034 * |
|COCHRAN-ARMITAGE | P=0.302 |
|FISHER EXACT | P=0.056 P=0.084 |
|==============================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 2/199 (1%) 1/199 (1%) 1/198 (1%) |
|ADJUSTED (b) | 1.5% 0.8% 0.8% |
|TERMINAL (d) | 2/135 (1%) 1/131 (1%) 0/102 (0%) |
|FIRST INCIDENCE (DAYS) | 387 (T) 387 (T) 320 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.660N P=0.510N P=0.585N |
|INCIDENTAL TUMOR | P=0.597N P=0.510N P=0.503N |
|LOGISTIC REGRESSION | P=0.625N P=0.510N P=0.549N |
|COCHRAN-ARMITAGE | P=0.572N |
|FISHER EXACT | P=0.500N P=0.502N |
|==============================================================================|
DATE: 05/20/95 EXPERIMENT: 05119 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE CD(1 CRL MICE OUTBRED CHARLES RIVER) -- DIETHYLPHTHALATE/DIMETHYLPHTHALATE
TERMINAL SACRIFICE AT 56 WEEKS
|==============================================================================|
|DOSE | ACETONE/ DMBA/DMP DMP/ACET |
| | ACETONE ONE |
|==============================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 2/199 (1%) 1/199 (1%) 1/198 (1%) |
|ADJUSTED (b) | 1.2% 0.6% 0.7% |
|TERMINAL (d) | 0/135 (0%) 0/131 (0%) 0/102 (0%) |
|FIRST INCIDENCE (DAYS) | 253 304 273 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.633N P=0.515N P=0.563N |
|INCIDENTAL TUMOR | P=0.391N P=0.448N P=0.316N |
|LOGISTIC REGRESSION | P=0.501N P=0.475N P=0.420N |
|COCHRAN-ARMITAGE | P=0.572N |
|FISHER EXACT | P=0.500N P=0.502N |
|==============================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferenti|ted
| Cell Type |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 2/199 (1%) 1/199 (1%) 1/198 (1%) |
|ADJUSTED (b) | 1.2% 0.6% 0.7% |
|TERMINAL (d) | 0/135 (0%) 0/131 (0%) 0/102 (0%) |
|FIRST INCIDENCE (DAYS) | 253 304 273 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.633N P=0.515N P=0.563N |
|INCIDENTAL TUMOR | P=0.391N P=0.448N P=0.316N |
|LOGISTIC REGRESSION | P=0.501N P=0.475N P=0.420N |
|COCHRAN-ARMITAGE | P=0.572N |
|FISHER EXACT | P=0.500N P=0.502N |
|==============================================================================|
DATE: 05/20/95 EXPERIMENT: 05119 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE CD(1 CRL MICE OUTBRED CHARLES RIVER) -- DIETHYLPHTHALATE/DIMETHYLPHTHALATE
TERMINAL SACRIFICE AT 56 WEEKS
|==============================================================================|
|DOSE | ACETONE/ DMBA/DMP DMP/ACET |
| | ACETONE ONE |
|==============================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 47/199 (24%) 60/199 (30%) 33/198 (17%) |
|ADJUSTED (b) | 34.2% 39.3% 30.5% |
|TERMINAL (d) | 45/135 (33%) 42/131 (32%) 28/102 (27%) |
|FIRST INCIDENCE (DAYS) | 323 141 320 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.104N P=0.063 P=0.392N |
|INCIDENTAL TUMOR | P=0.029N* P=0.075 P=0.325N |
|LOGISTIC REGRESSION | P=0.029N* P=0.063 P=0.299N |
|COCHRAN-ARMITAGE | P=0.004N** |
|FISHER EXACT | P=0.087 P=0.054N |
|==============================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 14/199 (7%) 14/199 (7%) 5/198 (3%) |
|ADJUSTED (b) | 9.8% 9.6% 4.6% |
|TERMINAL (d) | 11/135 (8%) 8/131 (6%) 4/102 (4%) |
|FIRST INCIDENCE (DAYS) | 253 259 273 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.065N P=0.542 P=0.095N |
|INCIDENTAL TUMOR | P=0.020N* P=0.548N P=0.048N* |
|LOGISTIC REGRESSION | P=0.026N* P=0.534 P=0.057N |
|COCHRAN-ARMITAGE | P=0.019N* |
|FISHER EXACT | P=0.577N P=0.029N* |
|==============================================================================|
DATE: 05/20/95 EXPERIMENT: 05119 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MALE CD(1 CRL MICE OUTBRED CHARLES RIVER) -- DIETHYLPHTHALATE/DIMETHYLPHTHALATE
TERMINAL SACRIFICE AT 56 WEEKS
|==============================================================================|
|DOSE | ACETONE/ DMBA/DMP DMP/ACET |
| | ACETONE ONE |
|==============================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|------------------------------------------------------------------------------|
|TUMOR RATES | # # # |
|----------- | |
|OVERALL (a) | 59/199 (30%) 65/199 (33%) 37/198 (19%) |
|ADJUSTED (b) | 41.9% 42.1% 33.8% |
|TERMINAL (d) | 54/135 (40%) 45/131 (34%) 31/102 (30%) |
|FIRST INCIDENCE (DAYS) | 253 141 273 |
|-----------------------| |
|STATISTICAL TESTS (f) | |
|-----------------------| |
|LIFE TABLE | P=0.055N P=0.231 P=0.159N |
|INCIDENTAL TUMOR | P=0.009N** P=0.278 P=0.088N |
|LOGISTIC REGRESSION | P=0.009N** P=0.239 P=0.082N |
|COCHRAN-ARMITAGE | P<0.001N** |
|FISHER EXACT | P=0.294 P=0.007N** |
|==============================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).