TDMS Study 05119-01 Pathology Tables
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
Facility: Hazleton, Maryland
Chemical CAS #: 84-66-2
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 1| 3| 3| 1| 3| 1| 1| 3| 1| 2| 3| 2| 3| 1| 1| 1| 1| 1| 3| 3| 1| 3| 1| 3| 3|
DAY ON TEST | 4| 9| 9| 4| 2| 8| 4| 5| 4| 5| 2| 2| 8| 4| 4| 4| 4| 4| 2| 8| 4| 9| 4| 9| 9|
| 1| 0| 0| 1| 7| 5| 1| 5| 1| 9| 9| 2| 8| 1| 1| 1| 1| 1| 0| 8| 2| 5| 6| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
DMBA/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + |
__________________________________________________________________________|
Intestine Small | |
__________________________________________________________________________|
Intestine Small, Ileum | |
Amyloid Deposition | |
Granuloma | |
__________________________________________________________________________|
Liver | + + + |
Abscess | 4 4 |
Amyloid Deposition | |
Angiectasis | |
Hematopoietic Cell Proliferation | 4 2 |
Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | |
Abscess | |
__________________________________________________________________________|
Salivary Glands | |
Hemorrhage | |
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
Abscess | |
Inflammation, Chronic, Focal | |
Atrium, Thrombosis | |
Epicardium, Inflammation, Suppurative| |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | |
__________________________________________________________________________|
Adrenal Gland, Cortex | |
__________________________________________________________________________|
Adrenal Gland, Medulla | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Abscess | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | |
Cyst | |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + |
Dilatation | 3 |
__________________________________________________________________________|
Seminal Vesicle | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 1| 3| 3| 1| 3| 1| 1| 3| 1| 2| 3| 2| 3| 1| 1| 1| 1| 1| 3| 3| 1| 3| 1| 3| 3|
DAY ON TEST | 4| 9| 9| 4| 2| 8| 4| 5| 4| 5| 2| 2| 8| 4| 4| 4| 4| 4| 2| 8| 4| 9| 4| 9| 9|
| 1| 0| 0| 1| 7| 5| 1| 5| 1| 9| 9| 2| 8| 1| 1| 1| 1| 1| 0| 8| 2| 5| 6| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
DMBA/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Abscess | |
Cyst | X |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia | 3 |
Hyperplasia, Re Cell | 3 |
Axillary, Abscess | 4 3 |
Axillary, Cyst | X |
Axillary, Depletion Lymphoid | 3 |
Axillary, Hyperplasia | 4 3 4 3 4 3 4 4 4 4 3 4 4 |
Inguinal, Hyperplasia | 3 3 |
Lumbar, Hyperplasia | |
Mediastinal, Abscess | |
Mediastinal, Hyperplasia | |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + |
Cyst | X |
Depletion Lymphoid | 3 |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia | 3 3 4 4 2 3 3 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
Hematopoietic Cell Proliferation | |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + |
Amyloid Deposition | 3 3 2 |
Granuloma | |
Hematopoietic Cell Proliferation | 2 3 4 4 4 4 3 4 3 4 3 3 3 3 3 4 3 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Other, Abscess | 4 |
Other, Acanthosis, Focal | 4 |
Other, Acanthosis | 2 3 2 2 2 3 2 2 2 2 3 2 3 2 |
Other, Edema | |
Other, Exudate | X X X X X X X X X X X X X |
Other, Hyperkeratosis | 2 2 1 2 2 2 1 1 2 2 2 |
Other, Inflammation, Subacute | 3 4 4 4 4 3 4 3 4 4 3 4 4 4 |
Other, Ulcer | 2 4 4 4 4 3 3 3 4 4 4 4 4 4 |
Sebaceous Gland, Site of | |
Application-Mass, Hyperplasia | |
Site of Application-Mass, Abscess | 4 |
Site of Application-Mass, Acanthosis,| |
Focal | 4 4 4 4 4 4 4 3|
Site of Application-Mass, Acanthosis | 1 |
Site of Application-Mass, Exudate | X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 1| 3| 3| 1| 3| 1| 1| 3| 1| 2| 3| 2| 3| 1| 1| 1| 1| 1| 3| 3| 1| 3| 1| 3| 3|
DAY ON TEST | 4| 9| 9| 4| 2| 8| 4| 5| 4| 5| 2| 2| 8| 4| 4| 4| 4| 4| 2| 8| 4| 9| 4| 9| 9|
| 1| 0| 0| 1| 7| 5| 1| 5| 1| 9| 9| 2| 8| 1| 1| 1| 1| 1| 0| 8| 2| 5| 6| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
DMBA/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Site of Application-Mass, | |
Hyperkeratosis, Focal | |
Site of Application-Mass, | |
Hyperplasia, Focal, Mast Cell | 2 |
Site of Application-Mass, | |
Inflammation, Subacute | 2 |
Site of Application-Mass, | |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Subacute | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Acanthosis | 3 2 2 3 2 2 2 3 2 3 2 2 2 3 3 2 2 3 2 2 2 3|
Cyst Epithelial Inclusion | |
Exudate | X X X X X X X X X X X X X X X X X|
Hyperkeratosis | 1 2 2 4 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2|
Inflammation, Subacute | 4 1 3 2 2 4 2 4 2 1 3 3 1 3 4 2 1 3 2|
Ulcer | 4 2 4 2 4 2 2 4 4 2 4 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 |
Leukocytosis | 3 3 2 2 |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 2 1 |
Interstitium, Inflammation, Chronic, | |
Focal | 2 1 2 |
Interstitium, Inflammation | 2 2 2 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 |
Inflammation, Suppurative | |
Cornea, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 1| 3| 3| 1| 3| 1| 1| 3| 1| 2| 3| 2| 3| 1| 1| 1| 1| 1| 3| 3| 1| 3| 1| 3| 3|
DAY ON TEST | 4| 9| 9| 4| 2| 8| 4| 5| 4| 5| 2| 2| 8| 4| 4| 4| 4| 4| 2| 8| 4| 9| 4| 9| 9|
| 1| 0| 0| 1| 7| 5| 1| 5| 1| 9| 9| 2| 8| 1| 1| 1| 1| 1| 0| 8| 2| 5| 6| 4| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
DMBA/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Retrobulbar, Inflammation, Subacute | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + |
Abscess | |
Infiltration Cellular, Focal, Plasma | |
Cell | 3 |
Nephropathy | |
Cortex, Atrophy | 4 4 |
Papilla, Necrosis | 2 |
Proximal Convoluted Renal Tubule, | |
Vacuolization Cytoplasmic | 3 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 1| 2| 3| 1| 1| 1| 3| 2| 1| 3| 3| 3| 3| 1| 2| 1| 2| 3| 1| 1| 3| 1| 1| 1| 2| |
DAY ON TEST | 4| 3| 8| 4| 4| 8| 1| 4| 4| 5| 9| 0| 4| 4| 9| 4| 6| 9| 4| 4| 9| 4| 3| 4| 7| |
| 2| 0| 8| 2| 2| 0| 9| 9| 2| 2| 4| 4| 2| 2| 8| 2| 2| 4| 2| 2| 4| 2| 0| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
DMBA/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | | 1 |
__________________________________________________________________________|____________|
Intestine Small | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
Amyloid Deposition | 3 | 1 3.0|
Granuloma | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + +| 8 |
Abscess | 1 4 4| 6 3.5|
Amyloid Deposition | 3 4| 2 3.5|
Angiectasis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 | 3 3.0|
Necrosis | 1 2 4| 6 2.7|
__________________________________________________________________________|____________|
Pancreas | + | 1 |
Abscess | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
Hemorrhage | 2 | 1 2.0|
Necrosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 4 |
Abscess | 4 | 1 4.0|
Inflammation, Chronic, Focal | 3 | 1 3.0|
Atrium, Thrombosis | X | 1 |
Epicardium, Inflammation, Suppurative| 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + | 1 |
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + + | 3 |
Abscess | 4 3 4 | 3 3.7|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + | 1 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | | 1 |
Dilatation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 1| 2| 3| 1| 1| 1| 3| 2| 1| 3| 3| 3| 3| 1| 2| 1| 2| 3| 1| 1| 3| 1| 1| 1| 2| |
DAY ON TEST | 4| 3| 8| 4| 4| 8| 1| 4| 4| 5| 9| 0| 4| 4| 9| 4| 6| 9| 4| 4| 9| 4| 3| 4| 7| |
| 2| 0| 8| 2| 2| 0| 9| 9| 2| 2| 4| 4| 2| 2| 8| 2| 2| 4| 2| 2| 4| 2| 0| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
DMBA/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + +| 35 |
Abscess | 4 | 1 4.0|
Cyst | | 1 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia | 3 3 3 | 4 3.0|
Hyperplasia, Re Cell | | 1 3.0|
Axillary, Abscess | | 2 3.5|
Axillary, Cyst | X | 2 |
Axillary, Depletion Lymphoid | | 1 3.0|
Axillary, Hyperplasia | 2 4 4 2 4 4 3 3 4 4 4 4 4 4 | 27 3.6|
Inguinal, Hyperplasia | | 2 3.0|
Lumbar, Hyperplasia | 3 | 1 3.0|
Mediastinal, Abscess | 4 | 1 4.0|
Mediastinal, Hyperplasia | 4 | 1 4.0|
Renal, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + +| 23 |
Cyst | | 1 |
Depletion Lymphoid | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 4.0|
Hyperplasia | 3 4 4 4 4 4 3 3 4 4 4 4 4| 21 3.6|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + +| 4 |
Hematopoietic Cell Proliferation | 4 4| 2 4.0|
Hyperplasia | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +| 42 |
Amyloid Deposition | 2 3 2 2 3 3| 9 2.6|
Granuloma | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 4 3 4 4 3 4 3 3 4 4 3 4 1 3 4 4 3 3 4 3 4 3 4| 43 3.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Other, Abscess | 4 4 4| 4 4.0|
Other, Acanthosis, Focal | | 1 4.0|
Other, Acanthosis | 2 2 3 2 2 2 2 2 3 3 1 3| 26 2.3|
Other, Edema | 3 | 1 3.0|
Other, Exudate | X X X X X X X X X| 22 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 1| 2| 3| 1| 1| 1| 3| 2| 1| 3| 3| 3| 3| 1| 2| 1| 2| 3| 1| 1| 3| 1| 1| 1| 2| |
DAY ON TEST | 4| 3| 8| 4| 4| 8| 1| 4| 4| 5| 9| 0| 4| 4| 9| 4| 6| 9| 4| 4| 9| 4| 3| 4| 7| |
| 2| 0| 8| 2| 2| 0| 9| 9| 2| 2| 4| 4| 2| 2| 8| 2| 2| 4| 2| 2| 4| 2| 0| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
DMBA/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Other, Hyperkeratosis | 1 1 2 2 2 2 2 2| 19 1.7|
Other, Inflammation, Subacute | 4 4 4 3 4 2 4 3 4 4 4| 25 3.7|
Other, Ulcer | 4 4 4 4 3 4 4 3 4 4 4 4| 26 3.7|
Sebaceous Gland, Site of | | |
Application-Mass, Hyperplasia | 4 | 1 4.0|
Site of Application-Mass, Abscess | 4 | 2 4.0|
Site of Application-Mass, Acanthosis,| | |
Focal | 2 3 4 | 11 3.6|
Site of Application-Mass, Acanthosis | | 1 1.0|
Site of Application-Mass, Exudate | | 1 |
Site of Application-Mass, | | |
Hyperkeratosis, Focal | 2 | 1 2.0|
Site of Application-Mass, | | |
Hyperplasia, Focal, Mast Cell | | 1 2.0|
Site of Application-Mass, | | |
Inflammation, Subacute | | 1 2.0|
Site of Application-Mass, | | |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperkeratosis | 2 | 1 2.0|
Inflammation, Subacute | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | 4 2 | 2 3.0|
Acanthosis | 1 2 2 2 2 2 2 2 2 3 2 2 3 2 2 3 3 2 2 2 2 3 2| 45 2.3|
Cyst Epithelial Inclusion | X | 1 |
Exudate | X X X X X X X X X X X X X X| 31 |
Hyperkeratosis | 1 2 1 1 2 2 2 2 1 2 3 1 2 2 2 2 1 1 2 2| 39 1.8|
Inflammation, Subacute | 2 4 2 2 2 4 3 3 4 4 3 4 2 4 3| 34 2.7|
Ulcer | 4 4 4 4 4 4 4 4 2 4 | 22 3.4|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 2| 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 1| 2| 3| 1| 1| 1| 3| 2| 1| 3| 3| 3| 3| 1| 2| 1| 2| 3| 1| 1| 3| 1| 1| 1| 2| |
DAY ON TEST | 4| 3| 8| 4| 4| 8| 1| 4| 4| 5| 9| 0| 4| 4| 9| 4| 6| 9| 4| 4| 9| 4| 3| 4| 7| |
| 2| 0| 8| 2| 2| 0| 9| 9| 2| 2| 4| 4| 2| 2| 8| 2| 2| 4| 2| 2| 4| 2| 0| 2| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
DMBA/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | 2 | 2 2.0|
Leukocytosis | 2 2 4 3 2 4 3 2| 12 2.7|
Alveolar Epithelium, Hyperplasia | | 1 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 1 1 2 | 8 1.5|
Interstitium, Inflammation, Chronic, | | |
Focal | 1 | 4 1.5|
Interstitium, Inflammation | 3 2 3 2 2 3 2 2 3| 13 2.3|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | | 1 3.0|
Inflammation, Suppurative | 3 | 1 3.0|
Cornea, Inflammation, Chronic | | 1 3.0|
Retrobulbar, Inflammation, Subacute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + +| 7 |
Abscess | 4 4 | 2 4.0|
Infiltration Cellular, Focal, Plasma | | |
Cell | | 1 3.0|
Nephropathy | 2 | 1 2.0|
Cortex, Atrophy | | 2 4.0|
Papilla, Necrosis | | 1 2.0|
Proximal Convoluted Renal Tubule, | | |
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 8| 6| 6| 8| 8| 8| 8| 8| 9| 8| 9| 9| 9| 7| 8| 9| 9| 7| 5| 9| 9| 9| 9| 9| 9|
| 7| 6| 8| 7| 7| 7| 7| 7| 9| 7| 4| 4| 4| 5| 3| 4| 4| 3| 6| 4| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DMBA/ACE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | + |
Inflammation, Subacute | 3 |
__________________________________________________________________________|
Liver | + + + + + + |
Abscess | 4 4 |
Amyloid Deposition | |
Hematopoietic Cell Proliferation | 3 2 4 |
Inflammation, Chronic, Focal | |
__________________________________________________________________________|
Mesentery | + + |
Abscess | 4 |
Fat, Necrosis, Focal | 2 |
__________________________________________________________________________|
Pancreas | +|
Edema | 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + |
Abscess | 4 |
Amyloid Deposition | 3 |
Atrium, Thrombosis | X |
Epicardium, Inflammation, Suppurative| 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Thyroid Gland | |
Amyloid Deposition | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Abscess | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + |
Abscess | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + |
Dilatation | 2 4 |
Fibrosis | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Hyperplasia | |
Axillary, Hyperplasia | |
Mediastinal, Hyperplasia | 3 |
Renal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 8| 6| 6| 8| 8| 8| 8| 8| 9| 8| 9| 9| 9| 7| 8| 9| 9| 7| 5| 9| 9| 9| 9| 9| 9|
| 7| 6| 8| 7| 7| 7| 7| 7| 9| 7| 4| 4| 4| 5| 3| 4| 4| 3| 6| 4| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DMBA/ACE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Abscess | 4 2 4 |
Hyperplasia | 4 3 4 3 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | +|
Depletion Lymphoid | 3|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Spleen | + + + + + + + + +|
Amyloid Deposition | 3 2 |
Hematopoietic Cell Proliferation | 4 1 3 3 4 3 3 4 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Other, Abscess | 3 2 |
Other, Acanthosis | 2 2 2 3 2 2 3 |
Other, Edema | 3 |
Other, Exudate | X X X X X |
Other, Hyperkeratosis | 3 2 2 4 2 1 |
Other, Inflammation, Subacute | 4 3 4 4 3 3 3 |
Other, Ulcer | 4 4 4 4 4 3 |
Site of Application-Mass, Acanthosis,| |
Focal | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 2 1 3 2 1 3 3 1 2|
Exudate | X X X X X|
Hyperkeratosis | 2 2 2 2 2 1 2 2 1 2|
Inflammation, Subacute | 2 3 2 4 2|
Ulcer | 2 4 2|
Sebaceous Gland, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Congestion | |
Inflammation, Chronic, Focal | |
Leukocytosis | 4 2 3 1 |
Alveolar Epithelium, Hyperplasia | 2 3 4 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 3 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 8| 6| 6| 8| 8| 8| 8| 8| 9| 8| 9| 9| 9| 7| 8| 9| 9| 7| 5| 9| 9| 9| 9| 9| 9|
| 7| 6| 8| 7| 7| 7| 7| 7| 9| 7| 4| 4| 4| 5| 3| 4| 4| 3| 6| 4| 5| 5| 5| 5| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DMBA/ACE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Bronchiole, Hyperplasia | 4 |
Bronchiole, Inflammation, Suppurative| 4 |
Bronchiole, Metaplasia | 4 |
Interstitium, Inflammation, Chronic, | |
Focal | 2 1 2 |
Interstitium, Inflammation | 2 2 4 2 3|
Pleura, Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + |
Abscess | |
Amyloid Deposition | |
Infiltration Cellular, Plasma Cell | 4 |
Infiltration Cellular, Lymphocyte | |
Nephropathy | 3 |
Cortex, Atrophy | |
Pelvis, Dilatation | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
DAY ON TEST | 9| 4| 9| 9| 6| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 9| 9| 9| 1| 9| 9| 9| 9| |
| 5| 2| 5| 5| 1| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 0| 6| 0| 0| 0| 6| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
DMBA/ACE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Small | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | | 1 |
Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + | 10 |
Abscess | 4 | 3 4.0|
Amyloid Deposition | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 3 | 5 3.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Abscess | | 1 4.0|
Fat, Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | | 1 |
Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 4 |
Abscess | | 1 4.0|
Amyloid Deposition | 3 | 2 3.0|
Atrium, Thrombosis | X | 2 |
Epicardium, Inflammation, Suppurative| | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + | 1 |
Amyloid Deposition | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + + + | 5 |
Abscess | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Penis | + + | 2 |
__________________________________________________________________________|____________|
Preputial Gland | | 1 |
Abscess | | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 5 |
Dilatation | 4 2 | 4 3.0|
Fibrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
DAY ON TEST | 9| 4| 9| 9| 6| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 9| 9| 9| 1| 9| 9| 9| 9| |
| 5| 2| 5| 5| 1| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 0| 6| 0| 0| 0| 6| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
DMBA/ACE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia | 3 | 1 3.0|
Axillary, Hyperplasia | 4 3 | 2 3.5|
Mediastinal, Hyperplasia | | 1 3.0|
Renal, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 10 |
Abscess | | 3 3.3|
Hyperplasia | 3 3 4 3 4 | 10 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 3 |
Depletion Lymphoid | | 1 3.0|
Hematopoietic Cell Proliferation | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 17 |
Amyloid Deposition | 2 3 2 | 5 2.4|
Hematopoietic Cell Proliferation | 4 3 3 4 4 3 3 | 16 3.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Other, Abscess | 3 4 3 | 5 3.0|
Other, Acanthosis | 2 2 3 2 3 3 3 3 | 15 2.5|
Other, Edema | | 1 3.0|
Other, Exudate | X X X X X X X | 12 |
Other, Hyperkeratosis | 1 1 | 8 2.0|
Other, Inflammation, Subacute | 4 4 4 4 3 4 4 | 14 3.6|
Other, Ulcer | 4 4 4 4 3 4 4 4 4 | 15 3.9|
Site of Application-Mass, Acanthosis,| | |
Focal | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 2 1 2 1 1 2 2 | 19 1.9|
Exudate | X X X X X | 10 |
Hyperkeratosis | 1 2 2 | 13 1.8|
Inflammation, Subacute | 1 2 3 | 8 2.4|
Ulcer | 3 1 1 2 | 7 2.1|
Sebaceous Gland, Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
DAY ON TEST | 9| 4| 9| 9| 6| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 9| 9| 9| 1| 9| 9| 9| 9| |
| 5| 2| 5| 5| 1| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 0| 6| 0| 0| 0| 6| 0| 0| 0| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
DMBA/ACE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | | 1 4.0|
Congestion | 3 | 1 3.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Leukocytosis | 2 3 3 | 7 2.6|
Alveolar Epithelium, Hyperplasia | | 3 3.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 | 3 2.3|
Bronchiole, Hyperplasia | | 1 4.0|
Bronchiole, Inflammation, Suppurative| | 1 4.0|
Bronchiole, Metaplasia | | 1 4.0|
Interstitium, Inflammation, Chronic, | | |
Focal | 4 | 4 2.3|
Interstitium, Inflammation | 3 1 1 | 8 2.3|
Pleura, Inflammation, Suppurative | 2 | 2 3.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + + | 3 |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 5 |
Abscess | 3 | 1 3.0|
Amyloid Deposition | 2 2 | 2 2.0|
Infiltration Cellular, Plasma Cell | | 1 4.0|
Infiltration Cellular, Lymphocyte | 4 | 1 4.0|
Nephropathy | | 1 3.0|
Cortex, Atrophy | 3 | 1 3.0|
Pelvis, Dilatation | 2 3 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 0| 1| 2| 1| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 2| 1| 3| 1| 3| 3|
DAY ON TEST | 5| 4| 8| 4| 9| 4| 9| 9| 2| 7| 9| 3| 2| 9| 4| 0| 4| 9| 4| 8| 9| 7| 4| 9| 9|
| 3| 2| 3| 2| 4| 2| 4| 4| 2| 7| 3| 8| 3| 3| 1| 4| 2| 3| 2| 4| 7| 3| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TPA | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | + |
__________________________________________________________________________|
Intestine Small, Ileum | |
__________________________________________________________________________|
Intestine Small, Jejunum | |
__________________________________________________________________________|
Liver | + + + + |
Abscess | 4 4 |
Amyloid Deposition | 3 1 |
Clear Cell Focus | |
Hematopoietic Cell Proliferation | 3 3 |
Necrosis | 4 2 4 |
__________________________________________________________________________|
Stomach | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Abscess | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + |
Hyperplasia | 2 |
Axillary, Hyperplasia | 4 4 4 3 4 3 4 |
Bronchial, Hyperplasia | |
Inguinal, Hyperplasia | 4 |
Lumbar, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + |
Abscess | 4 4 |
Cyst | |
Hyperplasia | 4 3 4 4 3 4 4 4 4 |
Lymphocyte, Necrosis | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Hyperplasia | |
Lymphocyte, Necrosis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + |
Amyloid Deposition | 3 3 2 |
Hematopoietic Cell Proliferation | 3 3 3 3 4 4 4 4 4 4 2 3 3 2 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 0| 1| 2| 1| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 2| 1| 3| 1| 3| 3|
DAY ON TEST | 5| 4| 8| 4| 9| 4| 9| 9| 2| 7| 9| 3| 2| 9| 4| 0| 4| 9| 4| 8| 9| 7| 4| 9| 9|
| 3| 2| 3| 2| 4| 2| 4| 4| 2| 7| 3| 8| 3| 3| 1| 4| 2| 3| 2| 4| 7| 3| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TPA | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Other, Abscess | 4 |
Other, Acanthosis | 3 2 2 3 2 3 2 2 2 2 3 3 3 2 |
Other, Exudate | X X X X X X X X X X X X |
Other, Hyperkeratosis | 3 2 2 2 2 2 2 2 |
Other, Inflammation, Subacute | 4 3 2 2 4 4 4 4 4 3 4 4 4 |
Other, Ulcer | 4 4 4 2 4 4 4 4 4 4 3 3 4 4 4 |
Site of Application-Mass, Acanthosis,| |
Focal | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 4 2 3 2 3 2 2 2 2 2 2 2 2 3 2 2 2 4 2 2 2 3|
Cyst Epithelial Inclusion | X |
Exudate | X X X X X X X X X X X X X |
Hyperkeratosis | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Inflammation, Subacute | 2 4 4 1 4 3 3 4 4 4 2 3 3|
Ulcer | 4 4 4 4 3 3 3 2 4 4 4 1 4 2 3 3|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Congestion | 2 2 2 |
Leukocytosis | X 3 2 4 2 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 1 |
Interstitium, Inflammation | 3 2 2 3 3 2 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + + |
__________________________________________________________________________|
Eye | + + + + |
Inflammation, Suppurative | 3 |
Cornea, Hyperplasia, Chronic | 3 |
Cornea, Hyperplasia, Focal | 2 |
Cornea, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 0| 1| 2| 1| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 2| 1| 3| 1| 3| 3|
DAY ON TEST | 5| 4| 8| 4| 9| 4| 9| 9| 2| 7| 9| 3| 2| 9| 4| 0| 4| 9| 4| 8| 9| 7| 4| 9| 9|
| 3| 2| 3| 2| 4| 2| 4| 4| 2| 7| 3| 8| 3| 3| 1| 4| 2| 3| 2| 4| 7| 3| 1| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
TPA | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
Dilatation | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + |
Abscess | 3 |
Amyloid Deposition | 2 |
Hematopoietic Cell Proliferation | |
Cortex, Atrophy | 3 |
Pelvis, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 2| 3| 1| 3| 1| 3| 2| 3| 1| 3| 1| 1| 1| 3| 1| 3| 3| 3| 3| 3| 3| 1| 1| 1| |
DAY ON TEST | 9| 2| 9| 4| 9| 4| 9| 6| 3| 8| 9| 4| 4| 4| 9| 4| 1| 9| 9| 9| 9| 2| 4| 0| 4| |
| 0| 8| 0| 1| 0| 1| 0| 0| 7| 0| 0| 1| 1| 2| 0| 2| 7| 0| 0| 0| 3| 9| 2| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TPA | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Small | + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 10 |
Abscess | 4 4 3 3 | 6 3.7|
Amyloid Deposition | 4 | 3 2.7|
Clear Cell Focus | X | 1 |
Hematopoietic Cell Proliferation | | 2 3.0|
Necrosis | 4 3 4 3 | 7 3.4|
__________________________________________________________________________|____________|
Stomach | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + +| 3 |
Abscess | 4 4| 2 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + +| 24 |
Hyperplasia | | 1 2.0|
Axillary, Hyperplasia | 4 4 4 4 3 4 4| 14 3.8|
Bronchial, Hyperplasia | 4| 1 4.0|
Inguinal, Hyperplasia | 3 | 2 3.5|
Lumbar, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + +| 17 |
Abscess | 4 | 3 4.0|
Cyst | X | 1 |
Hyperplasia | 4 3 4 4 3 4| 15 3.7|
Lymphocyte, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 2 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 2| 3| 1| 3| 1| 3| 2| 3| 1| 3| 1| 1| 1| 3| 1| 3| 3| 3| 3| 3| 3| 1| 1| 1| |
DAY ON TEST | 9| 2| 9| 4| 9| 4| 9| 6| 3| 8| 9| 4| 4| 4| 9| 4| 1| 9| 9| 9| 9| 2| 4| 0| 4| |
| 0| 8| 0| 1| 0| 1| 0| 0| 7| 0| 0| 1| 1| 2| 0| 2| 7| 0| 0| 0| 3| 9| 2| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TPA | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphocyte, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + +| 28 |
Amyloid Deposition | 3 3 3 2 | 7 2.7|
Hematopoietic Cell Proliferation | 4 3 3 4 3 3 4 3 3 3 3 3| 28 3.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Other, Abscess | 3 3 | 3 3.3|
Other, Acanthosis | 3 2 2 3 3 2 2 2 2 3 3| 25 2.4|
Other, Exudate | X X X X X| 17 |
Other, Hyperkeratosis | 2 1 2 2 1 1 1 2| 16 1.8|
Other, Inflammation, Subacute | 3 3 4 2 2 4 4 4 3 4 4| 24 3.5|
Other, Ulcer | 4 4 4 3 4 4 4 3 3 4 4| 26 3.7|
Site of Application-Mass, Acanthosis,| | |
Focal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 1 2.0|
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 3 2 2 1 2 3 2 2 2 1 2 2 3 2 2 2 3 2 1 3 3 2 1| 47 2.2|
Cyst Epithelial Inclusion | | 1 |
Exudate | X X X X X X X X X X X X | 25 |
Hyperkeratosis | 2 2 1 2 2 2 2 2 1 2 1 2 2 2 1 3 | 34 1.9|
Inflammation, Subacute | 3 2 4 2 3 2 2 2 3 3 2 2 2 2 4 4 2| 30 2.8|
Ulcer | 4 2 4 2 4 4 4 | 23 3.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4| 1 4.0|
Congestion | | 3 2.0|
Leukocytosis | 3 3 3 4 | 10 2.9|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 2| 3| 1| 3| 1| 3| 2| 3| 1| 3| 1| 1| 1| 3| 1| 3| 3| 3| 3| 3| 3| 1| 1| 1| |
DAY ON TEST | 9| 2| 9| 4| 9| 4| 9| 6| 3| 8| 9| 4| 4| 4| 9| 4| 1| 9| 9| 9| 9| 2| 4| 0| 4| |
| 0| 8| 0| 1| 0| 1| 0| 0| 7| 0| 0| 1| 1| 2| 0| 2| 7| 0| 0| 0| 3| 9| 2| 9| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
TPA | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Histiocyte | 2 | 4 1.5|
Interstitium, Inflammation | 3 4 | 9 2.7|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 5 |
__________________________________________________________________________|____________|
Eye | | 4 |
Inflammation, Suppurative | | 1 3.0|
Cornea, Hyperplasia, Chronic | | 1 3.0|
Cornea, Hyperplasia, Focal | | 1 2.0|
Cornea, Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Dilatation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 6 |
Abscess | | 1 3.0|
Amyloid Deposition | 3 2 | 3 2.3|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Cortex, Atrophy | 3 | 2 3.0|
Pelvis, Dilatation | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 1| 1| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 1| 3| 1| 3| 3| 1| 1| 3| 2| 1|
DAY ON TEST | 4| 4| 9| 4| 4| 4| 9| 9| 5| 5| 9| 9| 9| 8| 9| 4| 5| 4| 9| 9| 3| 3| 8| 3| 4|
| 2| 2| 3| 8| 4| 5| 3| 3| 9| 9| 5| 5| 4| 6| 5| 2| 3| 2| 5| 5| 8| 8| 7| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DEP/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | |
__________________________________________________________________________|
Liver | + |
Abscess | 4 |
Amyloid Deposition | |
Hematopoietic Cell Proliferation | 3 |
Inflammation, Chronic, Focal | |
Necrosis | 4 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | |
Edema | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | |
Abscess | |
Amyloid Deposition | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Abscess | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | + + |
Abscess | 4 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + |
Abscess | 4 |
Dilatation | 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 3 2 3 4 |
Axillary, Hyperplasia, Focal, | |
Lymphoid | |
Axillary, Hyperplasia | 4 3 4 3 4 3 4 4|
Axillary, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + |
Abscess | 4 |
Amyloid Deposition | |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 1| 1| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 1| 3| 1| 3| 3| 1| 1| 3| 2| 1|
DAY ON TEST | 4| 4| 9| 4| 4| 4| 9| 9| 5| 5| 9| 9| 9| 8| 9| 4| 5| 4| 9| 9| 3| 3| 8| 3| 4|
| 2| 2| 3| 8| 4| 5| 3| 3| 9| 9| 5| 5| 4| 6| 5| 2| 3| 2| 5| 5| 8| 8| 7| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DEP/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | |
Hyperplasia | 3 4 4 3 3 4 3 4 4 4 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
Hematopoietic Cell Proliferation | 3 3 3 |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 |
Hematopoietic Cell Proliferation | 3 3 4 3 3 3 3 3 3 3 3 3 4 4 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Other, Abscess | 2 3|
Other, Acanthosis | 2 3 2 3 3 3 2 2 2 3 3 3|
Other, Exudate | X X X X X X X X X X X|
Other, Hyperkeratosis | 1 2 2 2 2 2 1 2 2 |
Other, Inflammation, Subacute | 4 4 4 4 4 4 3 4 4 4 4 |
Other, Ulcer | 4 4 4 4 4 4 4 3 4 4 4 4|
Site of Application-Mass, Acanthosis,| |
Focal | 4 |
Site of Application-Mass, Acanthosis | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Inflammation, Subacute | 3 |
Ulcer | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 3 2 3 2 3 2 2 2 2 2 2 3 2 2 3 2 3 2 2 3 2|
Exudate | X X X X X X X X X X X X X X X|
Hyperkeratosis | 2 3 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2|
Inflammation, Subacute | 4 2 1 3 2 2 2 2 3 2 3 2 3 4 2 1 2 3 4 2 2 3|
Ulcer | 4 2 4 3 2 4 2 3 4 4 4 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Congestion | 3|
Leukocytosis | 2 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 1| 1| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 1| 3| 1| 3| 3| 1| 1| 3| 2| 1|
DAY ON TEST | 4| 4| 9| 4| 4| 4| 9| 9| 5| 5| 9| 9| 9| 8| 9| 4| 5| 4| 9| 9| 3| 3| 8| 3| 4|
| 2| 2| 3| 8| 4| 5| 3| 3| 9| 9| 5| 5| 4| 6| 5| 2| 3| 2| 5| 5| 8| 8| 7| 5| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DEP/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 |
Interstitium, Inflammation, Chronic, | |
Focal | 1 2 2 |
Interstitium, Inflammation | 2 2 3 2 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | |
Lids, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + |
Amyloid Deposition | 2 |
Cortex, Atrophy | 3 |
Cortex, Cyst | X |
Pelvis, Dilatation | |
__________________________________________________________________________|
Urethra | |
Inflammation, Acute | |
__________________________________________________________________________|
Urinary Bladder | + + |
Amyloid Deposition | |
Hemorrhage | |
Submucosa, Hemorrhage | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 2| 3| 1| 1| 1| 1| 1| 2| 2| 1| 1| 3| 1| 3| 3| 1| 3| 1| 3| 3| 2| |
DAY ON TEST | 3| 3| 3| 4| 8| 3| 4| 4| 2| 4| 4| 2| 5| 4| 4| 8| 4| 8| 8| 4| 8| 4| 8| 8| 6| |
| 8| 8| 8| 8| 8| 7| 1| 1| 6| 1| 1| 5| 9| 1| 1| 3| 1| 9| 9| 1| 9| 1| 9| 9| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
DEP/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + +| 7 |
Abscess | 4 4 4 4 | 5 4.0|
Amyloid Deposition | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 2 1 | 4 2.3|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Necrosis | 4 3| 3 3.7|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + | 1 |
Edema | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 2 |
Abscess | 4 | 1 4.0|
Amyloid Deposition | 2 | 1 2.0|
Atrium, Thrombosis | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Abscess | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Penis | + | 3 |
__________________________________________________________________________|____________|
Preputial Gland | | 2 |
Abscess | | 2 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + | 4 |
Abscess | | 1 4.0|
Dilatation | 4 | 3 3.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + +| 35 |
Cyst | X | 1 |
Hyperplasia | 1 | 5 2.6|
Axillary, Hyperplasia, Focal, | | |
Lymphoid | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 2| 3| 1| 1| 1| 1| 1| 2| 2| 1| 1| 3| 1| 3| 3| 1| 3| 1| 3| 3| 2| |
DAY ON TEST | 3| 3| 3| 4| 8| 3| 4| 4| 2| 4| 4| 2| 5| 4| 4| 8| 4| 8| 8| 4| 8| 4| 8| 8| 6| |
| 8| 8| 8| 8| 8| 7| 1| 1| 6| 1| 1| 5| 9| 1| 1| 3| 1| 9| 9| 1| 9| 1| 9| 9| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
DEP/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Axillary, Hyperplasia | 4 4 3 3 4 4 4 4 4 4 3 | 19 3.7|
Axillary, Hyperplasia, Plasma Cell | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + +| 22 |
Abscess | 4 | 2 4.0|
Amyloid Deposition | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 4 3| 2 3.5|
Hyperplasia | 4 4 4 4 4 3 3 3| 18 3.6|
Hyperplasia, Plasma Cell | 4 | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 5 |
Hematopoietic Cell Proliferation | 4 | 4 3.3|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + +| 32 |
Amyloid Deposition | 2 | 3 2.3|
Hematopoietic Cell Proliferation | 4 3 3 4 4 3 2 4 4 3 3 4 3 3 3 3 4| 32 3.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | 2 | 1 2.0|
Other, Abscess | 4 4| 4 3.3|
Other, Acanthosis | 3 3 3 2 3 4 3 3 2 2 3 2 2 3 3| 27 2.7|
Other, Exudate | X X X X X X X X X X X X| 23 |
Other, Hyperkeratosis | 2 2 2 2 2 2 2 3 2| 18 1.9|
Other, Inflammation, Subacute | 4 4 4 4 3 4 3 4 4 4 2 2 3 4| 26 3.7|
Other, Ulcer | 4 4 4 2 4 4 4 4 4 4 2 2 2 4| 26 3.7|
Site of Application-Mass, Acanthosis,| | |
Focal | | 1 4.0|
Site of Application-Mass, Acanthosis | 3| 1 3.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Exudate | X | 1 |
Inflammation, Subacute | 4 | 2 3.5|
Ulcer | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 2 2 3 2 2 3 3 2 2 3 2 2 2 3 2 2 2 3 2 2 | 43 2.4|
Exudate | X X X X X X X X X X X X X X X X X | 32 |
Hyperkeratosis | 1 2 2 3 2 2 2 2 2 2 3 1 2 | 31 2.0|
Inflammation, Subacute | 4 2 4 2 4 2 2 2 3 2 4 4 4 2 2 | 38 2.7|
Ulcer | 4 2 4 4 4 4 2 2 1 2 4 4 3 | 25 3.1|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 2| 3| 1| 1| 1| 1| 1| 2| 2| 1| 1| 3| 1| 3| 3| 1| 3| 1| 3| 3| 2| |
DAY ON TEST | 3| 3| 3| 4| 8| 3| 4| 4| 2| 4| 4| 2| 5| 4| 4| 8| 4| 8| 8| 4| 8| 4| 8| 8| 6| |
| 8| 8| 8| 8| 8| 7| 1| 1| 6| 1| 1| 5| 9| 1| 1| 3| 1| 9| 9| 1| 9| 1| 9| 9| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
DEP/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Abscess | 4 | 1 4.0|
Congestion | 2 | 2 2.5|
Leukocytosis | 1 4 3 1 1| 6 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 1 | 4 1.8|
Interstitium, Inflammation, Chronic, | | |
Focal | 2 3 | 5 2.0|
Interstitium, Inflammation | 2 2 2 | 8 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Eye | +| 1 |
Lids, Inflammation, Chronic | 2| 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + +| 6 |
Amyloid Deposition | 1 3 | 3 2.0|
Cortex, Atrophy | | 1 3.0|
Cortex, Cyst | | 1 |
Pelvis, Dilatation | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Urethra | + | 1 |
Inflammation, Acute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 6 |
Amyloid Deposition | 4 | 1 4.0|
Hemorrhage | 3 | 1 3.0|
Submucosa, Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3|
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 9| 9| 5| 9| 9| 9| 4| 9| 9| 9| 8| 6| 4| 6| 8|
| 4| 8| 8| 8| 8| 6| 8| 8| 7| 8| 3| 3| 0| 3| 2| 4| 2| 4| 4| 4| 9| 4| 1| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
DEP/ACET | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Jejunum | + |
Amyloid Deposition | 2 |
__________________________________________________________________________|
Liver | + + + + + + |
Abscess | |
Amyloid Deposition | 2 2 |
Inflammation, Chronic, Focal | 2 |
Necrosis | 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Pancreas | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
Abscess | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Thyroid Gland | + |
Amyloid Deposition | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Abscess | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + |
Abscess | 4 |
Dilatation | |
__________________________________________________________________________|
Seminal Vesicle | + + |
Dilatation | 3 4 |
Inflammation | |
__________________________________________________________________________|
Testes | + |
Tunic, Fibrosis | 3 |
Tunic, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Abscess | |
Cyst | |
Hyperplasia | |
Axillary, Hyperplasia | 4 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + +|
Abscess | |
Hyperplasia | 2 3 3 3 4 4 3 3|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3|
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 9| 9| 5| 9| 9| 9| 4| 9| 9| 9| 8| 6| 4| 6| 8|
| 4| 8| 8| 8| 8| 6| 8| 8| 7| 8| 3| 3| 0| 3| 2| 4| 2| 4| 4| 4| 9| 4| 1| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
DEP/ACET | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymphatic, Dilatation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Amyloid Deposition | 2 |
Hematopoietic Cell Proliferation | 4 |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + +|
Amyloid Deposition | 3 |
Hematopoietic Cell Proliferation | 3 4 3 3|
__________________________________________________________________________|
Thymus | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Other, Abscess | |
Other, Acanthosis | 2 3 3 3 2 3 2 3 3 2|
Other, Edema | 3 2 3 |
Other, Exudate | X X X X X X X X|
Other, Hyperkeratosis | 2 2 2 2 |
Other, Inflammation, Subacute | 4 2 4 2 3 4 4 3 4|
Other, Ulcer | 4 2 3 1 4 4 4 4 3 4|
Subcutaneous Tissue, Other, Exudate, | |
Focal | 4 |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Edema | 2 |
Ulcer | 3 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 2 1 2 1 1 2 2 2|
Exudate | X X X X X X X X|
Hyperkeratosis | 2 2 2 2 2 2 2|
Inflammation, Subacute | 1 2 3 3 |
Ulcer | 2 2 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Congestion | 2 |
Granuloma | |
Hemorrhage | 3 2 1 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3|
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 9| 9| 5| 9| 9| 9| 4| 9| 9| 9| 8| 6| 4| 6| 8|
| 4| 8| 8| 8| 8| 6| 8| 8| 7| 8| 3| 3| 0| 3| 2| 4| 2| 4| 4| 4| 9| 4| 1| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
DEP/ACET | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Chronic, Focal | 2 |
Leukocytosis | 3 3 2 3 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 2 2 2 3 1 |
Interstitium, Inflammation, Chronic, | |
Focal | 2 3 3 |
Interstitium, Inflammation | 1 3 2 2 2 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Cornea, Inflammation, Chronic | 1 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + |
Amyloid Deposition | 4 2 |
Cortex, Atrophy | 3 |
Cortex, Cyst | X |
Pelvis, Dilatation | |
Proximal Convoluted Renal Tubule, | |
Vacuolization Cytoplasmic | |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| |
DAY ON TEST | 8| 8| 8| 8| 8| 7| 1| 8| 8| 8| 8| 8| 8| 4| 8| 9| 8| 9| 9| 6| 9| 9| 9| 9| 9| |
| 9| 9| 9| 9| 9| 3| 8| 8| 8| 8| 8| 8| 8| 1| 5| 3| 2| 3| 3| 4| 3| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
DEP/ACET | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Small | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | | 1 |
Amyloid Deposition | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + | 9 |
Abscess | 4 | 1 4.0|
Amyloid Deposition | | 2 2.0|
Inflammation, Chronic, Focal | 1 2 | 3 1.7|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | M | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 1 |
Abscess | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | | 1 |
Amyloid Deposition | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + + + + + | 6 |
Abscess | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 2 |
Abscess | | 1 4.0|
Dilatation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 6 |
Dilatation | 3 3 3 | 5 3.2|
Inflammation | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Testes | | 1 |
Tunic, Fibrosis | | 1 3.0|
Tunic, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 18 |
Abscess | 4 | 1 4.0|
Cyst | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| |
DAY ON TEST | 8| 8| 8| 8| 8| 7| 1| 8| 8| 8| 8| 8| 8| 4| 8| 9| 8| 9| 9| 6| 9| 9| 9| 9| 9| |
| 9| 9| 9| 9| 9| 3| 8| 8| 8| 8| 8| 8| 8| 1| 5| 3| 2| 3| 3| 4| 3| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
DEP/ACET | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia | 3 | 1 3.0|
Axillary, Hyperplasia | 4 4 | 4 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + | 16 |
Abscess | 4 | 1 4.0|
Hyperplasia | 4 3 4 4 4 3 | 14 3.4|
Lymphatic, Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 2 |
Amyloid Deposition | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 4.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 13 |
Amyloid Deposition | 3 | 2 3.0|
Hematopoietic Cell Proliferation | 3 4 3 3 3 4 4 3 | 12 3.3|
__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Other, Abscess | 4 | 1 4.0|
Other, Acanthosis | 3 2 3 3 2 2 2 2 | 18 2.5|
Other, Edema | 3 | 4 2.8|
Other, Exudate | X X X X X X | 14 |
Other, Hyperkeratosis | 2 1 | 6 1.8|
Other, Inflammation, Subacute | 4 4 4 4 4 4 3 | 16 3.6|
Other, Ulcer | 4 4 4 4 4 3 3 3 | 18 3.4|
Subcutaneous Tissue, Other, Exudate, | | |
Focal | | 1 4.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | | 1 2.0|
Edema | | 1 2.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 2 2 2 2 2 | 14 1.7|
Exudate | X X X | 11 |
Hyperkeratosis | 1 | 8 1.9|
Inflammation, Subacute | 2 2 2 | 7 2.1|
Ulcer | 3 2 | 6 2.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| |
DAY ON TEST | 8| 8| 8| 8| 8| 7| 1| 8| 8| 8| 8| 8| 8| 4| 8| 9| 8| 9| 9| 6| 9| 9| 9| 9| 9| |
| 9| 9| 9| 9| 9| 3| 8| 8| 8| 8| 8| 8| 8| 1| 5| 3| 2| 3| 3| 4| 3| 3| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
DEP/ACET | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | | 1 4.0|
Congestion | | 1 2.0|
Granuloma | 2 | 1 2.0|
Hemorrhage | 2 1 | 5 1.8|
Inflammation, Chronic, Focal | | 1 2.0|
Leukocytosis | 2 | 6 2.5|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 2 | 8 2.0|
Interstitium, Inflammation, Chronic, | | |
Focal | 2 2 2 1 2 | 8 2.1|
Interstitium, Inflammation | 2 2 2 3 | 10 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 3 |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Inflammation, Chronic | | 2 1.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 5 |
Amyloid Deposition | 3 4 | 4 3.3|
Cortex, Atrophy | 3 | 2 3.0|
Cortex, Cyst | | 1 |
Pelvis, Dilatation | 2 2 | 2 2.0|
Proximal Convoluted Renal Tubule, | | |
Vacuolization Cytoplasmic | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 8| 8| 5| 8| 8| 1| 8| 8| 8| 8| 8| 8| 8|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 3| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DMBA/DEP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Small | |
__________________________________________________________________________|
Intestine Small, Ileum | |
Granuloma | |
__________________________________________________________________________|
Liver | + + + + + + |
Amyloid Deposition | 3 |
Basophilic Focus | |
Hematopoietic Cell Proliferation | 3 2 |
Inflammation, Chronic, Focal | 2 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 2 |
Centrilobular, Cytomegaly | 2 |
__________________________________________________________________________|
Mesentery | |
Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | |
Edema | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | |
Inflammation | |
Spermatocele | |
__________________________________________________________________________|
Penis | + |
Edema | 2 |
__________________________________________________________________________|
Preputial Gland | + + |
Abscess | 4 |
Dilatation | 2 |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + |
Dilatation | 2 3 4 |
Fibrosis | 2 |
__________________________________________________________________________|
Testes | + |
Seminiferous Tubule, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + + |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 8| 8| 5| 8| 8| 1| 8| 8| 8| 8| 8| 8| 8|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 3| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DMBA/DEP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Abscess | 4 4 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia | 4 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Hemorrhage | 3 |
Infarct | |
__________________________________________________________________________|
Spleen | + + + + + + + |
Amyloid Deposition | 2 2 |
Hematopoietic Cell Proliferation | 3 3 2 3 3 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Other, Abscess | |
Other, Acanthosis | 1 3 3 3 |
Other, Edema | 3 |
Other, Exudate | X X X |
Other, Hyperkeratosis | 2 |
Other, Inflammation, Subacute | 3 4 4 2 |
Other, Ulcer | 3 4 3 4 |
Sebaceous Gland, Site of | |
Application-Mass, Hyperplasia | 4 |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
Ulcer | 2 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 2 3 2 |
Exudate | X X X |
Hyperkeratosis | 2 2 2 2 |
Hyperplasia, Focal, Mast Cell | 2 |
Inflammation, Subacute | 2 4 |
Ulcer | 2 4 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 2 |
Leukocytosis | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 8| 8| 5| 8| 8| 1| 8| 8| 8| 8| 8| 8| 8|
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 3| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DMBA/DEP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 |
Interstitium, Inflammation, Chronic, | |
Focal | 1 2 3 2 |
Interstitium, Inflammation | 2 3 3 |
__________________________________________________________________________|
Trachea | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Cornea, Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + |
Amyloid Deposition | 2 4 3 3 |
Cortex, Cyst | X |
Pelvis, Dilatation | 2 3 1 |
__________________________________________________________________________|
Urinary Bladder | + |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| |
DAY ON TEST | 8| 8| 8| 8| 8| 9| 4| 9| 9| 9| 9| 9| 9| 9| 4| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| |
| 7| 7| 7| 7| 7| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
DMBA/DEP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Small | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
Granuloma | 4 | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + | 8 |
Amyloid Deposition | | 1 3.0|
Basophilic Focus | X | 1 |
Hematopoietic Cell Proliferation | | 2 2.5|
Inflammation, Chronic, Focal | | 1 2.0|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | | 1 2.0|
Centrilobular, Cytomegaly | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + | 1 |
Edema | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + +| 4 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + | 1 |
Inflammation | 2 | 1 2.0|
Spermatocele | X | 1 |
__________________________________________________________________________|____________|
Penis | | 1 |
Edema | | 1 2.0|
__________________________________________________________________________|____________|
Preputial Gland | | 2 |
Abscess | | 1 4.0|
Dilatation | | 1 2.0|
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 6 |
Dilatation | 3 3 3 | 6 3.0|
Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| |
DAY ON TEST | 8| 8| 8| 8| 8| 9| 4| 9| 9| 9| 9| 9| 9| 9| 4| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| |
| 7| 7| 7| 7| 7| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
DMBA/DEP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Seminiferous Tubule, Atrophy | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 4 |
Abscess | | 2 4.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 2 |
Hemorrhage | | 1 3.0|
Infarct | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | | 7 |
Amyloid Deposition | | 2 2.0|
Hematopoietic Cell Proliferation | | 7 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Other, Abscess | 4 | 1 4.0|
Other, Acanthosis | 2 | 6 2.3|
Other, Edema | 2 | 2 2.5|
Other, Exudate | | 3 |
Other, Hyperkeratosis | | 1 2.0|
Other, Inflammation, Subacute | 3 | 5 3.2|
Other, Ulcer | 4 | 6 3.7|
Sebaceous Gland, Site of | | |
Application-Mass, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | | 1 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 3 | 6 2.7|
Exudate | X X | 5 |
Hyperkeratosis | 2 | 5 2.0|
Hyperplasia, Focal, Mast Cell | | 1 2.0|
Inflammation, Subacute | 2 3 | 4 2.8|
Ulcer | 2 4 | 5 2.6|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| |
DAY ON TEST | 8| 8| 8| 8| 8| 9| 4| 9| 9| 9| 9| 9| 9| 9| 4| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| |
| 7| 7| 7| 7| 7| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
DMBA/DEP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 3 | 2 2.5|
Hemorrhage | 3 | 3 2.3|
Leukocytosis | 2 | 2 2.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 | 3 2.0|
Interstitium, Inflammation, Chronic, | | |
Focal | 3 2 2 3 2 1 2 | 11 2.1|
Interstitium, Inflammation | 2 2 | 5 2.4|
__________________________________________________________________________|____________|
Trachea | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Cornea, Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 7 |
Amyloid Deposition | 4 | 5 3.2|
Cortex, Cyst | | 1 |
Pelvis, Dilatation | 2 | 4 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 8| 7| 8| 0| 8| 8| 8| 8| 8| 6| 9| 6| 9| 9| 8| 9| 9| 9| 0| 9| 8| 8| 6| 8| 8|
| 9| 0| 9| 9| 9| 9| 9| 9| 9| 7| 5| 9| 5| 5| 9| 5| 5| 5| 1| 5| 8| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
DEP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Liver | + + + + + + |
Abscess | 4 4 |
Amyloid Deposition | 2 |
Clear Cell Focus | X X |
Cyst | |
Hematopoietic Cell Proliferation | 2 3 |
Inflammation, Chronic, Focal | 3 2 2 |
Necrosis | 2 4 |
Vacuolization Cytoplasmic | 2 2 |
__________________________________________________________________________|
Mesentery | + |
Necrosis | 3 |
__________________________________________________________________________|
Pancreas | + |
Edema | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + |
Amyloid Deposition | 2 1 |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Abscess | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + |
Abscess | 4 |
__________________________________________________________________________|
Seminal Vesicle | + + + |
Dilatation | 2 2 3 |
Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + +|
Congestion | 4 |
Hyperplasia | 4 |
Iliac, Abscess | 4 |
Iliac, Hyperplasia | 4 |
Renal, Abscess | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + |
Hyperplasia | 4 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 8| 7| 8| 0| 8| 8| 8| 8| 8| 6| 9| 6| 9| 9| 8| 9| 9| 9| 0| 9| 8| 8| 6| 8| 8|
| 9| 0| 9| 9| 9| 9| 9| 9| 9| 7| 5| 9| 5| 5| 9| 5| 5| 5| 1| 5| 8| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
DEP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | 4 |
Hyperplasia | |
Hyperplasia, Re Cell | 3|
__________________________________________________________________________|
Spleen | + + + + +|
Amyloid Deposition | |
Hematopoietic Cell Proliferation | 3 4 3 4 3|
__________________________________________________________________________|
Thymus | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Other, Abscess | 4 |
Other, Acanthosis | 2 3 3 3 3 |
Other, Edema | 2 3 |
Other, Exudate | X X |
Other, Hyperkeratosis | 2 2 3 |
Other, Inflammation, Subacute | 3 3 2 3 4 4 |
Other, Ulcer | 4 4 4 |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Edema | 3 |
Exudate | X |
Inflammation, Subacute | 3 2 |
Ulcer | 4 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 2 2 2 2 1 |
Edema | 3 |
Exudate | X X X X X |
Hyperkeratosis | 2 2 2 |
Inflammation, Subacute | 2 2 4 |
Ulcer | 1 1 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 1 3 |
Inflammation, Chronic, Focal | 2 |
Leukocytosis | 4 |
Alveolar Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 8| 7| 8| 0| 8| 8| 8| 8| 8| 6| 9| 6| 9| 9| 8| 9| 9| 9| 0| 9| 8| 8| 6| 8| 8|
| 9| 0| 9| 9| 9| 9| 9| 9| 9| 7| 5| 9| 5| 5| 9| 5| 5| 5| 1| 5| 8| 8| 3| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
DEP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 3 |
Interstitium, Inflammation, Chronic, | |
Focal | 4 1 3 2 |
Interstitium, Inflammation | 2 3 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + |
Abscess | 4 |
Amyloid Deposition | 3 3 |
Hematopoietic Cell Proliferation | |
Pelvis, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| |
DAY ON TEST | 8| 8| 7| 5| 8| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 7| 9| |
| 9| 9| 7| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
DEP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + | 11 |
Abscess | | 2 4.0|
Amyloid Deposition | 2 2 | 3 2.0|
Clear Cell Focus | | 2 |
Cyst | X | 1 |
Hematopoietic Cell Proliferation | 4 | 3 3.0|
Inflammation, Chronic, Focal | | 3 2.3|
Necrosis | 4 | 3 3.3|
Vacuolization Cytoplasmic | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | | 1 |
Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 3 |
Amyloid Deposition | 2 | 3 1.7|
Atrium, Thrombosis | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 3 |
Abscess | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 4 |
Abscess | 3 4 | 3 3.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + +| 9 |
Dilatation | 2 4 3 3 2| 8 2.6|
Inflammation, Subacute | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 8 |
Congestion | | 1 4.0|
Hyperplasia | 3 | 2 3.5|
Iliac, Abscess | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| |
DAY ON TEST | 8| 8| 7| 5| 8| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 7| 9| |
| 9| 9| 7| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
DEP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Iliac, Hyperplasia | | 1 4.0|
Renal, Abscess | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 3 |
Hyperplasia | 4 | 3 3.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 3 |
Hemorrhage | | 1 4.0|
Hyperplasia | 2 | 1 2.0|
Hyperplasia, Re Cell | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + | 9 |
Amyloid Deposition | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 3 3 | 9 3.2|
__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Other, Abscess | 4 | 2 4.0|
Other, Acanthosis | 2 3 2 3 2 2 | 11 2.5|
Other, Edema | | 2 2.5|
Other, Exudate | X X | 4 |
Other, Hyperkeratosis | 2 2 | 5 2.2|
Other, Inflammation, Subacute | 3 4 3 4 4 | 11 3.4|
Other, Ulcer | 2 4 2 3 4 4 | 9 3.4|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 | 1 1.0|
Edema | | 1 3.0|
Exudate | | 1 |
Inflammation, Subacute | | 2 2.5|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 3 2 2 | 9 1.9|
Edema | | 1 3.0|
Exudate | X X X | 8 |
Hyperkeratosis | 2 2 2 | 6 2.0|
Inflammation, Subacute | 4 | 4 3.0|
Ulcer | 4 2 | 5 2.4|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| |
DAY ON TEST | 8| 8| 7| 5| 8| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 7| 9| |
| 9| 9| 7| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
DEP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Hemorrhage | 3 | 3 2.3|
Inflammation, Chronic, Focal | 2 | 2 2.0|
Leukocytosis | 4 | 2 4.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 2 2.5|
Interstitium, Inflammation, Chronic, | | |
Focal | 2 2 1 2 2 | 9 2.1|
Interstitium, Inflammation | 2 3 | 5 2.6|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 5 |
Abscess | | 1 4.0|
Amyloid Deposition | 3 2 | 4 2.8|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Pelvis, Dilatation | 2 3 2 | 3 2.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + | 3 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 1| 3| 1| 1| 1| 1| 1| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 1| 3| 3| 3| 1| 1| 2|
DAY ON TEST | 9| 4| 9| 4| 4| 4| 4| 7| 0| 9| 3| 4| 4| 8| 4| 8| 3| 8| 4| 8| 6| 8| 4| 4| 9|
| 0| 1| 0| 1| 1| 1| 1| 3| 3| 0| 7| 1| 1| 9| 1| 9| 7| 9| 1| 9| 2| 7| 1| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DMP/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Liver | + + + + |
Abscess | 4 4 |
Amyloid Deposition | 2 |
Hematopoietic Cell Proliferation | 3 |
Inflammation, Chronic, Focal | |
Necrosis, Focal | 3 |
Necrosis | 3 |
__________________________________________________________________________|
Stomach | |
__________________________________________________________________________|
Stomach, Forestomach | |
__________________________________________________________________________|
Stomach, Glandular | |
__________________________________________________________________________|
Tongue | +|
Abscess | 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Penis | + + + |
Abscess | 3 4 |
__________________________________________________________________________|
Preputial Gland | + + |
Abscess | 4 4 |
__________________________________________________________________________|
Testes | +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + +|
Abscess | |
Hyperplasia | 3 4 |
Axillary, Hematopoietic Cell | |
Proliferation | |
Axillary, Hyperplasia | 4 4 4 4 4 3 3 3 4 4 4|
Inguinal, Hyperplasia | |
Mediastinal, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + +|
Abscess | |
Hyperplasia | 4 4 4 4 4 4 4 4 3 4 4 4|
Hyperplasia, Plasma Cell | 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 1| 3| 1| 1| 1| 1| 1| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 1| 3| 3| 3| 1| 1| 2|
DAY ON TEST | 9| 4| 9| 4| 4| 4| 4| 7| 0| 9| 3| 4| 4| 8| 4| 8| 3| 8| 4| 8| 6| 8| 4| 4| 9|
| 0| 1| 0| 1| 1| 1| 1| 3| 3| 0| 7| 1| 1| 9| 1| 9| 7| 9| 1| 9| 2| 7| 1| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DMP/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 3 2 |
Hematopoietic Cell Proliferation | 3 3 3 3 3 4 3 3 4 3 3 4 3 3 3 4 3 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Other, Abscess | |
Other, Acanthosis | 3 2 3 1 2 3 2 3 2 2 2 2|
Other, Exudate | X X X X X X X X|
Other, Hyperkeratosis | 1 2 2 2 2 2 1 1|
Other, Inflammation, Subacute | 4 4 4 2 4 3 4 3 4 4 4|
Other, Ulcer | 4 4 4 4 4 4 4 3 4 4 4|
Site of Application-Mass, Acanthosis,| |
Focal | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Exudate | X |
Hyperkeratosis | 2 2 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Acanthosis | 3 3 2 2 3 2 4 3 2 2 2 2 3 3 3 2 3 3 3 2 2 2 2 2|
Exudate | X X X X X X X X X X X X X X X X X X |
Hyperkeratosis | 2 2 2 1 1 3 2 1 3 3 2 2 2 2 2 2 2 2 1 2|
Inflammation, Subacute | 2 4 2 4 3 2 4 4 4 4 2 3 4 2 2 3 3 4 4 2 2|
Ulcer | 3 4 4 4 4 4 4 3 4 4 4 4 4 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis | |
Congestion | 3 3 |
Hemorrhage | 2 |
Leukocytosis | 2 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 1 |
Interstitium, Inflammation, Chronic, | |
Focal | 2 |
Interstitium, Inflammation | 2 3 |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 1| 3| 1| 1| 1| 1| 1| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 1| 3| 3| 3| 1| 1| 2|
DAY ON TEST | 9| 4| 9| 4| 4| 4| 4| 7| 0| 9| 3| 4| 4| 8| 4| 8| 3| 8| 4| 8| 6| 8| 4| 4| 9|
| 0| 1| 0| 1| 1| 1| 1| 3| 3| 0| 7| 1| 1| 9| 1| 9| 7| 9| 1| 9| 2| 7| 1| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DMP/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Cornea, Hyperplasia | |
Cornea, Inflammation, Chronic | 3 |
Lids, Cornea, Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + |
Abscess | |
Amyloid Deposition | |
Cortex, Atrophy | |
Cortex, Infiltration Cellular, | |
Plasma Cell | 3 |
Papilla, Mineralization | 2 |
Papilla, Necrosis | |
Pelvis, Dilatation | 2 |
Proximal Convoluted Renal Tubule, | |
Necrosis | |
Proximal Convoluted Renal Tubule, | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Urinary Bladder | + |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 2| 3| 3| 3| 3| 1| 1| 2| 1| 1| 3| 2| 3| 3| 3| 1| 3| 3| 2| 3| 1| 1| 1| 1| 3| |
DAY ON TEST | 9| 5| 2| 4| 4| 4| 4| 5| 4| 4| 9| 8| 3| 9| 2| 4| 9| 8| 8| 9| 4| 4| 4| 4| 9| |
| 9| 7| 0| 2| 8| 2| 2| 6| 2| 2| 3| 4| 4| 3| 5| 2| 4| 3| 4| 4| 2| 2| 2| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
DMP/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + | 10 |
Abscess | 4 | 3 4.0|
Amyloid Deposition | 2 3 | 3 2.3|
Hematopoietic Cell Proliferation | 2 | 2 2.5|
Inflammation, Chronic, Focal | 2 2 | 2 2.0|
Necrosis, Focal | | 1 3.0|
Necrosis | 4 | 2 3.5|
__________________________________________________________________________|____________|
Stomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Abscess | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Penis | | 3 |
Abscess | | 2 3.5|
__________________________________________________________________________|____________|
Preputial Gland | | 2 |
Abscess | | 2 4.0|
__________________________________________________________________________|____________|
Testes | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + | 29 |
Abscess | 4 | 1 4.0|
Hyperplasia | 4 4 4 | 5 3.8|
Axillary, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
Axillary, Hyperplasia | 3 4 4 4 4 4 4 4 4 4 | 21 3.8|
Inguinal, Hyperplasia | 3 3 | 2 3.0|
Mediastinal, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 22 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 2| 3| 3| 3| 3| 1| 1| 2| 1| 1| 3| 2| 3| 3| 3| 1| 3| 3| 2| 3| 1| 1| 1| 1| 3| |
DAY ON TEST | 9| 5| 2| 4| 4| 4| 4| 5| 4| 4| 9| 8| 3| 9| 2| 4| 9| 8| 8| 9| 4| 4| 4| 4| 9| |
| 9| 7| 0| 2| 8| 2| 2| 6| 2| 2| 3| 4| 4| 3| 5| 2| 4| 3| 4| 4| 2| 2| 2| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
DMP/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Abscess | 4 4 4 | 3 4.0|
Hyperplasia | 4 4 4 3 4 3 3 4 4 4 | 22 3.8|
Hyperplasia, Plasma Cell | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + | 34 |
Amyloid Deposition | 1 2 3 3 2 | 9 2.2|
Hematopoietic Cell Proliferation | 3 4 4 3 4 3 4 3 3 3 4 3 3 3 3 | 33 3.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Other, Abscess | 4 4 | 2 4.0|
Other, Acanthosis | 3 3 3 2 3 3 2 3 2 | 21 2.4|
Other, Exudate | X X X X X | 13 |
Other, Hyperkeratosis | 1 2 3 | 11 1.7|
Other, Inflammation, Subacute | 4 4 4 4 4 2 4 4 | 19 3.7|
Other, Ulcer | 4 4 4 4 3 4 3 4 4 | 20 3.9|
Site of Application-Mass, Acanthosis,| | |
Focal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | | 1 2.0|
Exudate | | 1 |
Hyperkeratosis | | 2 2.0|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | 2 | 2 3.0|
Acanthosis | 2 2 2 1 2 3 1 2 2 2 2 2 2 2 2 3 3 2 3 3 2 2 2| 47 2.3|
Exudate | X X X X X X X X X X X X | 30 |
Hyperkeratosis | 1 2 2 2 3 2 2 2 1 2 2 2 3 2 | 35 2.0|
Inflammation, Subacute | 3 2 2 4 3 2 2 4 4 3 3 4 2 4 2 2 4 | 38 3.0|
Ulcer | 3 4 4 2 2 4 4 4 3 4 4 4 4 | 27 3.6|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 2| 3| 3| 3| 3| 1| 1| 2| 1| 1| 3| 2| 3| 3| 3| 1| 3| 3| 2| 3| 1| 1| 1| 1| 3| |
DAY ON TEST | 9| 5| 2| 4| 4| 4| 4| 5| 4| 4| 9| 8| 3| 9| 2| 4| 9| 8| 8| 9| 4| 4| 4| 4| 9| |
| 9| 7| 0| 2| 8| 2| 2| 6| 2| 2| 3| 4| 4| 3| 5| 2| 4| 3| 4| 4| 2| 2| 2| 2| 4| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
DMP/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Atelectasis | 4 | 1 4.0|
Congestion | | 2 3.0|
Hemorrhage | | 1 2.0|
Leukocytosis | 2 2 3 | 5 2.2|
Alveolar Epithelium, Hyperplasia | 3 | 2 2.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | | 3 1.7|
Interstitium, Inflammation, Chronic, | | |
Focal | | 1 2.0|
Interstitium, Inflammation | | 2 2.5|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + + + | 5 |
Cornea, Hyperplasia | 3 | 1 3.0|
Cornea, Inflammation, Chronic | 3 | 2 3.0|
Lids, Cornea, Inflammation, Subacute | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 4 |
Abscess | 3 | 1 3.0|
Amyloid Deposition | 2 2 | 2 2.0|
Cortex, Atrophy | 4 | 1 4.0|
Cortex, Infiltration Cellular, | | |
Plasma Cell | | 1 3.0|
Papilla, Mineralization | | 1 2.0|
Papilla, Necrosis | 3 | 1 3.0|
Pelvis, Dilatation | | 1 2.0|
Proximal Convoluted Renal Tubule, | | |
Necrosis | 3 | 1 3.0|
Proximal Convoluted Renal Tubule, | | |
Vacuolization Cytoplasmic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 9| 8| 9| 9| 9| 9| 8| 5| 9| 9| 9| 8| 9| 9| 9| 3| 9| 7| 9| 8| 8| 8| 8| 8|
| 0| 0| 8| 0| 0| 0| 0| 9| 7| 0| 0| 0| 3| 0| 0| 0| 2| 0| 9| 0| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
DMP/ACET | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Liver | + + + + + + |
Abscess | 4 |
Amyloid Deposition | 1 2 2 |
Hematopoietic Cell Proliferation | 4 3 |
Inflammation, Chronic, Focal | 2 |
Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + |
__________________________________________________________________________|
Stomach | + |
__________________________________________________________________________|
Stomach, Glandular | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + |
Amyloid Deposition | 3 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Pituitary Gland | + |
Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Penis | + |
Edema | |
__________________________________________________________________________|
Preputial Gland | + + |
Abscess | 4 |
Dilatation | 3 |
__________________________________________________________________________|
Seminal Vesicle | M + + +|
Dilatation | 2 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + |
Cyst | |
Hyperplasia | 4 3 4 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 3 |
__________________________________________________________________________|
Spleen | + + + + + |
Amyloid Deposition | |
Congestion | 3 |
Hematopoietic Cell Proliferation | 3 3 3 4 3 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 9| 8| 9| 9| 9| 9| 8| 5| 9| 9| 9| 8| 9| 9| 9| 3| 9| 7| 9| 8| 8| 8| 8| 8|
| 0| 0| 8| 0| 0| 0| 0| 9| 7| 0| 0| 0| 3| 0| 0| 0| 2| 0| 9| 0| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
DMP/ACET | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Other, Abscess | 4 |
Other, Acanthosis | 3 2 3 3 2 2 3 |
Other, Edema | 3 3 |
Other, Exudate | X X X X X |
Other, Hyperkeratosis | 2 2 3 |
Other, Inflammation, Subacute | 3 3 4 3 4 |
Other, Ulcer | 3 3 3 4 3 3 4 |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation, Subacute | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 3 2 1 2 3 |
Exudate | X X X |
Hyperkeratosis | 3 |
Inflammation, Subacute | 2 |
Ulcer | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Congestion | 2 |
Fibrosis, Focal | |
Foreign Body | 3 |
Hemorrhage | 3 2 |
Leukocytosis | 3 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 |
Interstitium, Inflammation, Chronic, | |
Focal | 1 1 2 1 3 2 1 |
Interstitium, Inflammation | 2 2 2 3 |
Pleura, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 9| 8| 9| 9| 9| 9| 8| 5| 9| 9| 9| 8| 9| 9| 9| 3| 9| 7| 9| 8| 8| 8| 8| 8|
| 0| 0| 8| 0| 0| 0| 0| 9| 7| 0| 0| 0| 3| 0| 0| 0| 2| 0| 9| 0| 8| 8| 8| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
DMP/ACET | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | + + |
Cornea, Inflammation, Chronic | 3 |
Cornea, Inflammation, Subacute | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + |
Abscess | 4 |
Amyloid Deposition | 3 3 4 3 |
Pelvis, Dilatation | 3 2 |
__________________________________________________________________________|
Urinary Bladder | +|
Calculus Micro Observation Only | X|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
DAY ON TEST | 8| 8| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 7| 6| 8| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| |
| 8| 8| 5| 3| 8| 9| 9| 9| 9| 9| 9| 9| 1| 0| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
DMP/ACET | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 14 |
Abscess | | 1 4.0|
Amyloid Deposition | 2 1 | 5 1.6|
Hematopoietic Cell Proliferation | 4 | 3 3.7|
Inflammation, Chronic, Focal | 1 2 2 2 2 | 6 1.8|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | | 1 |
__________________________________________________________________________|____________|
Stomach | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | | 1 |
Amyloid Deposition | | 1 3.0|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | | 1 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 4 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Penis | + | 2 |
Edema | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | | 2 |
Abscess | | 1 4.0|
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 7 |
Dilatation | 3 2 2 | 6 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + | 8 |
Hyperplasia | 2 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 6 |
Cyst | X | 1 |
Hyperplasia | 3 | 5 3.4|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | | 1 |
Hematopoietic Cell Proliferation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
DAY ON TEST | 8| 8| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 7| 6| 8| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| |
| 8| 8| 5| 3| 8| 9| 9| 9| 9| 9| 9| 9| 1| 0| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
DMP/ACET | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | A + + | 7 |
Amyloid Deposition | 2 | 1 2.0|
Congestion | | 1 3.0|
Hematopoietic Cell Proliferation | 4 3 | 7 3.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Other, Abscess | 4 | 2 4.0|
Other, Acanthosis | 3 3 2 2 | 11 2.5|
Other, Edema | 3 3 | 4 3.0|
Other, Exudate | X X X X | 9 |
Other, Hyperkeratosis | 2 | 4 2.3|
Other, Inflammation, Subacute | 2 4 3 | 8 3.3|
Other, Ulcer | 3 4 3 4 2 | 12 3.3|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Inflammation, Subacute | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 2 2 | 9 2.0|
Exudate | X X | 5 |
Hyperkeratosis | | 1 3.0|
Inflammation, Subacute | 2 2 | 3 2.0|
Ulcer | 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 | 1 4.0|
Congestion | 2 2 2 | 4 2.0|
Fibrosis, Focal | 2 | 1 2.0|
Foreign Body | | 1 3.0|
Hemorrhage | 2 | 3 2.3|
Leukocytosis | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
DAY ON TEST | 8| 8| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 7| 6| 8| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| |
| 8| 8| 5| 3| 8| 9| 9| 9| 9| 9| 9| 9| 1| 0| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
DMP/ACET | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 | 4 1.8|
Interstitium, Inflammation, Chronic, | | |
Focal | 1 | 8 1.5|
Interstitium, Inflammation | | 4 2.3|
Pleura, Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + + | 5 |
__________________________________________________________________________|____________|
Eye | | 2 |
Cornea, Inflammation, Chronic | | 1 3.0|
Cornea, Inflammation, Subacute | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 8 |
Abscess | | 1 4.0|
Amyloid Deposition | 2 | 5 3.0|
Pelvis, Dilatation | 2 1 | 4 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + A + | 3 |
Calculus Micro Observation Only | | 1 |
Congestion | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|
DAY ON TEST | 8| 6| 8| 7| 8| 3| 8| 8| 8| 8| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 5|
| 7| 1| 7| 5| 7| 4| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 7| 7| 7| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DMBA/DMP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Intestine Large | |
__________________________________________________________________________|
Intestine Large, Cecum | |
Edema | |
Inflammation, Chronic | |
Necrosis | |
__________________________________________________________________________|
Intestine Small | + |
__________________________________________________________________________|
Intestine Small, Duodenum | |
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Ileum | |
Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Jejunum | A |
Amyloid Deposition | |
__________________________________________________________________________|
Liver | + + + + + |
Abscess | 4 |
Amyloid Deposition | 2 |
Clear Cell Focus, Multiple | 4 |
Cytomegaly | 3 |
Inflammation, Chronic, Focal | 3 2 2 |
__________________________________________________________________________|
Pancreas | + |
Edema | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + |
Amyloid Deposition | 2 3 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Thyroid Gland | + |
Amyloid Deposition | 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | |
Abscess | |
Dilatation | |
__________________________________________________________________________|
Prostate | +|
Hemorrhage | 4|
__________________________________________________________________________|
Seminal Vesicle | + |
Dilatation | 3 |
__________________________________________________________________________|
Testes | + |
Amyloid Deposition | 3 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|
DAY ON TEST | 8| 6| 8| 7| 8| 3| 8| 8| 8| 8| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 5|
| 7| 1| 7| 5| 7| 4| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 7| 7| 7| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DMBA/DMP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Seminiferous Tubule, Atrophy | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Lymph Node | |
Hematopoietic Cell Proliferation | |
Axillary, Hyperplasia | |
Pancreatic, Hematopoietic Cell | |
Proliferation | |
__________________________________________________________________________|
Lymph Node, Mandibular | |
Cyst | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | |
Cyst | |
__________________________________________________________________________|
Spleen | + + |
Hematopoietic Cell Proliferation | 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Other, Acanthosis | 2 |
Other, Edema | 3 2 3 2 |
Other, Exudate | X |
Other, Hyperkeratosis | |
Other, Inflammation, Subacute | 2 |
Other, Ulcer | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 3 2 |
Ulcer | 2 |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 2 2 |
Edema | |
Exudate | X |
Hyperkeratosis | |
Inflammation, Subacute | 2 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atelectasis | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0|
DAY ON TEST | 8| 6| 8| 7| 8| 3| 8| 8| 8| 8| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 5|
| 7| 1| 7| 5| 7| 4| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 7| 7| 7| 4| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DMBA/DMP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 2 3 3 |
Fibrosis, Focal | |
Hemorrhage | 3 2 2 2 2 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 3 3 2 2 |
Interstitium, Inflammation, Chronic, | |
Focal | 2 4 1 2 2 |
Interstitium, Inflammation | 2 3 2 2 2 3 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + |
Amyloid Deposition | 3 4 4 3 3 |
Infarct | 3 |
Nephropathy | 2 |
Cortex, Cyst | X X |
Pelvis, Dilatation | 2 3 3 |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| |
DAY ON TEST | 8| 8| 8| 8| 8| 9| 8| 3| 8| 9| 9| 9| 6| 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9| |
| 8| 8| 7| 8| 8| 5| 9| 0| 2| 5| 5| 5| 9| 5| 5| 5| 5| 7| 5| 5| 5| 5| 2| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
DMBA/DMP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Intestine Large | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
Edema | 3 3 | 2 3.0|
Inflammation, Chronic | 3 | 1 3.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + | 4 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 1 |
Amyloid Deposition | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 3 |
Amyloid Deposition | 4 4 | 2 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 2 |
Amyloid Deposition | 3 | 1 3.0|
__________________________________________________________________________|____________|
Liver | +| 6 |
Abscess | | 1 4.0|
Amyloid Deposition | | 1 2.0|
Clear Cell Focus, Multiple | | 1 4.0|
Cytomegaly | | 1 3.0|
Inflammation, Chronic, Focal | 1| 4 2.0|
__________________________________________________________________________|____________|
Pancreas | + + | 3 |
Edema | 3 2 | 3 2.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 3 |
Amyloid Deposition | 2 | 3 2.3|
Atrium, Thrombosis | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | | 1 |
Amyloid Deposition | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 4 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
Abscess | 3 | 1 3.0|
Dilatation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Prostate | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| |
DAY ON TEST | 8| 8| 8| 8| 8| 9| 8| 3| 8| 9| 9| 9| 6| 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9| |
| 8| 8| 7| 8| 8| 5| 9| 0| 2| 5| 5| 5| 9| 5| 5| 5| 5| 7| 5| 5| 5| 5| 2| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
DMBA/DMP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hemorrhage | | 1 4.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 3 |
Dilatation | 2 2 | 3 2.3|
__________________________________________________________________________|____________|
Testes | | 1 |
Amyloid Deposition | | 1 3.0|
Seminiferous Tubule, Atrophy | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Axillary, Hyperplasia | 4 | 1 4.0|
Pancreatic, Hematopoietic Cell | | |
Proliferation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 1 |
Cyst | X | 1 |
Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
Cyst | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + | 4 |
Hematopoietic Cell Proliferation | 3 3 | 4 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Other, Acanthosis | 2 3 3 | 4 2.5|
Other, Edema | 3 | 5 2.6|
Other, Exudate | X X X | 4 |
Other, Hyperkeratosis | 2 | 1 2.0|
Other, Inflammation, Subacute | 3 4 4 | 4 3.3|
Other, Ulcer | 3 4 4 | 3 3.7|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 3 2.3|
Ulcer | | 1 2.0|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 3 | 7 1.7|
Edema | 3 | 1 3.0|
Exudate | X | 2 |
Hyperkeratosis | 1 1 | 2 1.0|
Inflammation, Subacute | 1 2 | 3 1.7|
Ulcer | 2 2 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| |
DAY ON TEST | 8| 8| 8| 8| 8| 9| 8| 3| 8| 9| 9| 9| 6| 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9| |
| 8| 8| 7| 8| 8| 5| 9| 0| 2| 5| 5| 5| 9| 5| 5| 5| 5| 7| 5| 5| 5| 5| 2| 5| 5| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
DMBA/DMP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atelectasis | 4 | 1 4.0|
Congestion | 2 3 2 | 6 2.5|
Fibrosis, Focal | 2 | 1 2.0|
Hemorrhage | 2 2 2 | 9 2.1|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 3 | 5 2.6|
Interstitium, Inflammation, Chronic, | | |
Focal | 3 1 | 7 2.1|
Interstitium, Inflammation | 2 2 2 2 3| 11 2.3|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 10 |
Amyloid Deposition | 3 3 | 7 3.3|
Infarct | | 1 3.0|
Nephropathy | | 1 2.0|
Cortex, Cyst | X | 3 |
Pelvis, Dilatation | 2 | 4 2.5|
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 2 |
Hemorrhage | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 1| 8| 8| 8| 6| 8| 8| 8| 8| 8| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8|
| 7| 4| 8| 8| 6| 8| 8| 8| 8| 8| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + + + + M M + + + + + + + + + + +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 |
Edema | |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +|
Cortex, Amyloid Deposition | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 1 2 1 1 1 1 2 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 4 4 4 3 4 4 4 4 4 4 |
Hemorrhage | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 2 2 2 2 3 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 2 2 2 2 2 |
Basophilic Focus | X |
Hematopoietic Cell Proliferation | |
Hyperplasia | 3 |
Inflammation, Chronic, Focal | 2 2 2 2 2 1 2 2 2 2 2 2 |
Karyomegaly | |
Necrosis | 2 |
Vacuolization Cytoplasmic | 2 |
Vacuolization Nuclear | 3 3 |
Hepatocyte, Hyperplasia | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 2 2 |
Inflammation, Subacute | |
__________________________________________________________________________|
Salivary Glands | + M + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 3 3 2 2 3 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia, Glandular | |
Mucosa, Hyperplasia | 3 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 |
Inflammation, Chronic | 2 |
Mucosa, Dilatation | 2 |
Mucosa, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 1| 8| 8| 8| 6| 8| 8| 8| 8| 8| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8|
| 7| 4| 8| 8| 6| 8| 8| 8| 8| 8| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Amyloid Deposition | 1 3 1 2 3 3 2 2 1 2 2 |
Inflammation, Chronic, Focal | 1|
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adrenal Gland, Amyloid Deposition | 4 |
Capsule, Hyperplasia | 2 1 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 2 3 3 4 2 3 4 |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | |
Pigmentation | 2 2 2 2 2 2 3 3 2 1 2 2 2 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + M + + + + + + + + + + + + + M M + + M + +|
Amyloid Deposition | 2 2 2 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 3 1 2 3 2 2 2 2 1 |
Follicle, Dilatation | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Abscess | 4 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | |
__________________________________________________________________________|
Penis | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Preputial Gland | + |
Abscess | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Inflammation, Chronic | 2 |
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 1| 8| 8| 8| 6| 8| 8| 8| 8| 8| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8|
| 7| 4| 8| 8| 6| 8| 8| 8| 8| 8| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 1 4 |
Inflammation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 4 2 3 2 1 |
Fibrosis | |
Inflammation, Chronic | |
Interstitial Cell, Hyperplasia | 2 3 2 |
Seminiferous Tubule, Degeneration | 4 3 4 3 3 2 3 2 1 1 |
Seminiferous Tubule, Giant Cell | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Axillary, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + +|
Amyloid Deposition | |
Cyst | X |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 4 3 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + A + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Amyloid Deposition | 2 3 2 2 2 2 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 |
Hematopoietic Cell Proliferation | 3 3 2 3 2 2 1 4 2 2 2 3 2 3 2 2 1 2 2 2 2 2 2 2|
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + I + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M + + M + M M M M M M M M M M M M + M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Other, Abscess | 4 4 |
Other, Acanthosis | 3 2 2 |
Other, Edema | |
Other, Exudate | X X X |
Other, Hyperkeratosis | |
Other, Inflammation, Subacute | 4 4 2 4 |
Other, Ulcer | 4 4 1 4 |
Site of Application-Mass, Acanthosis,| |
Focal | 4 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 1| 8| 8| 8| 6| 8| 8| 8| 8| 8| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8|
| 7| 4| 8| 8| 6| 8| 8| 8| 8| 8| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | |
Inflammation, Subacute | |
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 1 2 2 2 1 2|
Exudate | X X X X|
Hyperkeratosis | 2 2 2|
Inflammation, Subacute | 2 2 2 2 1 2|
Ulcer | 2 2 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Thalamus, Mineralization, Focal | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Congestion | 2 |
Alveolar Epithelium, Hyperplasia | 2 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 3 2 |
Interstitium, Inflammation, Chronic, | |
Focal | 2 2 1 2 3 |
Interstitium, Inflammation | 3 2 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Amyloid Deposition | 2 4 3 3 3 4 3 2 2 4 |
Infarct | 3 |
Nephropathy | 2 2 1 2 2 2 1|
Cortex, Cyst | X X |
Pelvis, Dilatation | 2 2 2 2 3 2 |
__________________________________________________________________________|
Urinary Bladder | + M + A + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 1| 8| 8| 8| 6| 8| 8| 8| 8| 8| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8|
| 7| 4| 8| 8| 6| 8| 8| 8| 8| 8| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Calculus Micro Observation Only | X X X |
Inflammation | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
DAY ON TEST | 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 9| 5| 9| 9| 9| 9| 9| 9| 9| 8| |
| 7| 7| 1| 7| 0| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + A| 46 |
Amyloid Deposition | | 2 1.5|
Edema | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + M + + + + + + A + + + + + + + A| 45 |
Edema | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + M + + A| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cortex, Amyloid Deposition | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Amyloid Deposition | 1 2 1 2 1 2 2 2 2| 17 1.5|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Amyloid Deposition | 3 4 2 4 4 4 4 3 4 3 4 4 4 4 3 3| 28 3.6|
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Amyloid Deposition | 2 3 2 2 2 2 2 4 2 2 2 2| 20 2.3|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | 2 2 2 2 2 2 2 2 2| 16 2.1|
Basophilic Focus | X | 2 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | | 1 3.0|
Inflammation, Chronic, Focal | 2 2 2 2 2 2 2 1 2 2 1 2 1 1 2 1 | 28 1.8|
Karyomegaly | 3 | 1 3.0|
Necrosis | 3 3 | 3 2.7|
Vacuolization Cytoplasmic | | 1 2.0|
Vacuolization Nuclear | 4 3 | 4 3.3|
Hepatocyte, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 3 3 2 | 7 2.3|
Inflammation, Subacute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Amyloid Deposition | 2 2 2 2 3 4 2 3| 16 2.4|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Mucosa, Hyperplasia, Glandular | 3 | 1 3.0|
Mucosa, Hyperplasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
DAY ON TEST | 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 9| 5| 9| 9| 9| 9| 9| 9| 9| 8| |
| 7| 7| 1| 7| 0| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Amyloid Deposition | 2 3 2 2 2 2| 9 2.1|
Inflammation, Chronic | | 1 2.0|
Mucosa, Dilatation | | 1 2.0|
Mucosa, Hyperplasia | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | | 1 2.0|
Amyloid Deposition | 1 2 2 2 2 1 1 2 3 2 3 3 2 3 2| 26 2.0|
Inflammation, Chronic, Focal | 1 | 2 1.0|
Atrium, Thrombosis | X X | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Adrenal Gland, Amyloid Deposition | | 1 4.0|
Capsule, Hyperplasia | 1 2 2 2 2 1 2 2 2 1 2 1 1| 22 1.7|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Amyloid Deposition | 3 4 2 3 2 2 2 4 3 3 2 3 3| 21 2.9|
Hyperplasia, Focal | | 1 2.0|
Hypertrophy, Focal | 2 | 1 2.0|
Pigmentation | 2 2 3 2 2 3 2 2 3 3 1 2 | 26 2.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + M M + + M + M + + + M + + + + + M + + M| 34 |
Amyloid Deposition | 2 2 2 2 3 3 1 1 | 12 1.9|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia, Focal | 2| 1 2.0|
Pars Distalis, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | 1 3 2 1 1 3 2 2 3 2 2 2 2 3| 24 2.0|
Follicle, Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 3 |
Abscess | | 2 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
DAY ON TEST | 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 9| 5| 9| 9| 9| 9| 9| 9| 9| 8| |
| 7| 7| 1| 7| 0| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Spermatocele | X | 1 |
__________________________________________________________________________|____________|
Penis | + + | 2 |
Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + | 2 |
Abscess | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 |
Abscess | | 1 3.0|
Inflammation, Chronic | 2 | 2 2.0|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 3 3 | 6 2.5|
Inflammation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | 2 3 4 1 4| 11 2.7|
Fibrosis | 4 | 1 4.0|
Inflammation, Chronic | 3 | 1 3.0|
Interstitial Cell, Hyperplasia | 3 3| 5 2.6|
Seminiferous Tubule, Degeneration | 3 3 1 2 4 3 2 2 2 2 4| 21 2.6|
Seminiferous Tubule, Giant Cell | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + M + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 3 | 2 3.0|
Axillary, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Amyloid Deposition | 2 | 1 2.0|
Cyst | X | 2 |
Hematopoietic Cell Proliferation | 3 | 2 2.5|
Hyperplasia | 3 3 4 | 6 3.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +| 47 |
Abscess | 3 | 1 3.0|
Amyloid Deposition | 1 2 4 2 | 11 2.2|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 3 | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | 2 1 2 2 4 2 | 8 2.1|
Hematopoietic Cell Proliferation | 2 3 1 1 4 2 3 2 2 2 2 2 1 1 2 2 2 1 2 2 2 4 2| 47 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
DAY ON TEST | 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 9| 5| 9| 9| 9| 9| 9| 9| 9| 8| |
| 7| 7| 1| 7| 0| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pigmentation, Hemosiderin | 1 2| 2 1.5|
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + + + + + + + M + + M + M + M + +| 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M + M M M| 6 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Other, Abscess | | 2 4.0|
Other, Acanthosis | 2 2 2 3 | 7 2.3|
Other, Edema | 2 3 3| 3 2.7|
Other, Exudate | X X | 5 |
Other, Hyperkeratosis | 1 2 | 2 1.5|
Other, Inflammation, Subacute | 4 3 4 4 | 8 3.6|
Other, Ulcer | 4 3 4 4 | 8 3.5|
Site of Application-Mass, Acanthosis,| | |
Focal | | 1 4.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 1 | 1 1.0|
Inflammation, Subacute | 1 | 1 1.0|
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 2 2 1 1 | 11 1.6|
Exudate | X X X | 7 |
Hyperkeratosis | 1 | 4 1.8|
Inflammation, Subacute | 3 | 7 2.0|
Ulcer | 4 2 2 | 6 2.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + M + + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Thalamus, Mineralization, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | 2 | 1 2.0|
Congestion | 2 2 3 3 | 5 2.4|
Alveolar Epithelium, Hyperplasia | 2 3 | 4 2.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 | 4 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| |
DAY ON TEST | 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 9| 5| 9| 9| 9| 9| 9| 9| 9| 8| |
| 7| 7| 1| 7| 0| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T |
ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A |
ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Interstitium, Inflammation, Chronic, | | |
Focal | 2 4 3 3 | 9 2.4|
Interstitium, Inflammation | 3 | 4 2.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | 4 | 1 4.0|
Amyloid Deposition | 3 3 3 2 2 3 4 3 3 3 2 3 3| 23 2.9|
Infarct | | 1 3.0|
Nephropathy | 2 2 2 2 2 1 2 4 | 15 1.9|
Cortex, Cyst | X X X X X X X | 9 |
Pelvis, Dilatation | 2 2 3 2 2 2 3| 13 2.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + I + + + + + + + + + + + + + +| 46 |
Calculus Micro Observation Only | X X X | 6 |
Inflammation | 2 | 1 2.0|
Mucosa, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 9| 8| 8| 8| 8| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 7| 6| 9| 9| 9| 9|
| 0| 0| 9| 9| 1| 6| 0| 0| 7| 0| 5| 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + A + + + + + + + + + + A A + + M +|
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Necrosis | 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + A A + + + +|
Amyloid Deposition | |
Edema | 4 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + A + + + +|
Amyloid Deposition | 1 2 1 1 1 2 3 2 1 1|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + A A + + + +|
Amyloid Deposition | 3 4 3 3 3 3 3 3 3 4 4 4 3 3 4|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + M + + + + A A + + + +|
Amyloid Deposition | 2 2 1 2 2 2 2 1 2 3 2 1|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Amyloid Deposition | 2 2 2 2 2 2 2 2|
Cyst Multilocular | |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 3 4 |
Inflammation, Chronic, Focal | 2 1 1 1 2 1 2 2 2 1 1 2 2 2 1 1|
Karyomegaly | |
Necrosis | 2 1 |
Regeneration, Focal | |
Vacuolization Cytoplasmic | |
Centrilobular, Cytomegaly | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 3 |
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 2 2 2 4 4 2 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 2 2 1 1|
Dilatation | |
Inflammation, Chronic | |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 9| 8| 8| 8| 8| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 7| 6| 9| 9| 9| 9|
| 0| 0| 9| 9| 1| 6| 0| 0| 7| 0| 5| 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Amyloid Deposition | 2 2 2 1 2 2 2 1 1 2 2 2 3 2 2 2 2|
Inflammation, Chronic, Focal | 2 2 |
Atrium, Thrombosis | |
Ventricle, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | 2 |
Capsule, Hyperplasia | 2 1 3 2 3 2 2 2 2 2 2 3|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 3 2 2 2 2 4 2 3 3 3 3 2 3 3|
Hyperplasia, Focal | |
Hypertrophy, Focal | |
Infiltration Cellular, Plasma Cell | |
Infiltration Cellular, Plasma Cell, | |
Lymphocyte | |
Pigmentation | 2 2 2 1 1 1 2 2 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M M M M M M M M M + M M M M M + M M M + + M M M|
Amyloid Deposition | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | |
Pars Intermedia, Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + A + + + + + + + + + + + + I + + + + + +|
Amyloid Deposition | 2 2 1 2 2 2 2 1 2 3 3 2 2 1|
Follicle, Dilatation | 3 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Abscess | |
Granuloma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Abscess | 4 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Penis | + + + |
__________________________________________________________________________|
Preputial Gland | +|
Inflammation | 3|
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 9| 8| 8| 8| 8| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 7| 6| 9| 9| 9| 9|
| 0| 0| 9| 9| 1| 6| 0| 0| 7| 0| 5| 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + M + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 3 4 3|
Fibrosis | |
Inflammation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 1 2 3 3 |
Interstitial Cell, Hyperplasia | 1 2 1 |
Seminiferous Tubule, Degeneration | 3 2 1 1 2 3 1 3 2 1 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Hyperplasia | 3 |
Mediastinal, Hyperplasia | |
Pancreatic, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +|
Abscess | 4 |
Amyloid Deposition | 2 |
Cyst | X |
Hyperplasia | 3 3 3 4 4 3 4 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + M M + + A A + + M +|
Abscess | |
Amyloid Deposition | 2 2 2 2 2 3 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 3 |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 1 2 2 2 3|
Hematopoietic Cell Proliferation | 2 4 2 2 3 2 3 4 2 2 1 2 1 2 1 3 3 1 3 3 2 2 3 |
__________________________________________________________________________|
Thymus | + + + + M + + + M + + + + + + + + + + + + + + + I|
Cyst | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M + M M M M + M M M + M M + M M + M + M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Other, Abscess | |
Other, Acanthosis | 3 2 3 3 2 2 2 2|
Other, Edema | |
Other, Exudate | X X X X X X X|
Other, Hyperkeratosis | 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 9| 8| 8| 8| 8| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 7| 6| 9| 9| 9| 9|
| 0| 0| 9| 9| 1| 6| 0| 0| 7| 0| 5| 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Other, Inflammation, Subacute | 4 2 4 3 4 4 4|
Other, Ulcer | 4 4 3 4 4 4 4 4 4|
Site of Application-Mass, Acanthosis,| |
Focal | |
__________________________________________________________________________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 1 2 2 1 2 |
Exudate | X X X |
Hyperkeratosis | 2 |
Inflammation, Subacute | 3 1 2 2 1 1 1 |
Ulcer | 2 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + M + +|
Thalamus, Mineralization, Focal | 1 1 1 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Amyloid Deposition | 2 |
Atelectasis | |
Congestion | 3 |
Hemorrhage | |
Leukocytosis | 4 3 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolar Epithelium, Metaplasia, | |
Focal, Squamous | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 |
Bronchiole, Inflammation, | |
Proliferative | 3 |
Interstitium, Inflammation, Chronic, | |
Focal | 4 |
Interstitium, Inflammation | 2 3 3 |
Pleura, Fibrosis, Focal | |
Pleura, Inflammation, Suppurative | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + I + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 9| 9| 8| 8| 8| 8| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 7| 6| 9| 9| 9| 9|
| 0| 0| 9| 9| 1| 6| 0| 0| 7| 0| 5| 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Inflammation, Chronic | |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 3 |
Amyloid Deposition | 3 3 2 3 2 2 2 4 2 2 3 2 4 4 2 3|
Infiltration Cellular, Plasma Cell | 3 |
Nephropathy | 2 2 2 2 3 |
Cortex, Cyst | X X X |
Pelvis, Dilatation | 2 3 2 2 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + A + + + + + + + + + + + + + A A + + + +|
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| |
DAY ON TEST | 9| 9| 9| 9| 9| 7| 9| 9| 9| 1| 5| 9| 8| 9| 1| 9| 9| 7| 9| 6| 9| 9| 2| 9| 9| |
| 0| 0| 0| 0| 0| 9| 5| 5| 5| 6| 3| 5| 9| 9| 2| 3| 3| 7| 3| 7| 3| 3| 8| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + A + M + + + + + + A + + + + +| 42 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mucosa, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + M + + + + + +| 46 |
Amyloid Deposition | 2 | 1 2.0|
Edema | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + M| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Amyloid Deposition | 1 2 1 2 3 3 | 16 1.7|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Amyloid Deposition | 3 2 3 3 3 4 3 2 3 4 4 4 3 2 | 29 3.2|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + M + +| 44 |
Amyloid Deposition | 2 2 2 2 3 2 3 | 19 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 4 4 | 3 4.0|
Amyloid Deposition | 2 4 2 2 3 | 13 2.2|
Cyst Multilocular | X | 1 |
Eosinophilic Focus | X | 1 |
Hematopoietic Cell Proliferation | 3 3 4 2 2 2 2 | 9 2.8|
Inflammation, Chronic, Focal | 2 2 2 2 2 2 2 2 2 2| 26 1.7|
Karyomegaly | 3 | 1 3.0|
Necrosis | 2 4 | 4 2.3|
Regeneration, Focal | 2 | 1 2.0|
Vacuolization Cytoplasmic | 3 | 1 3.0|
Centrilobular, Cytomegaly | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 4 2.3|
Hypertrophy, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 2 2 3 4 | 14 2.5|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 2 2 | 7 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| |
DAY ON TEST | 9| 9| 9| 9| 9| 7| 9| 9| 9| 1| 5| 9| 8| 9| 1| 9| 9| 7| 9| 6| 9| 9| 2| 9| 9| |
| 0| 0| 0| 0| 0| 9| 5| 5| 5| 6| 3| 5| 9| 9| 2| 3| 3| 7| 3| 7| 3| 3| 8| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Dilatation | 2 | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
Necrosis, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 3 | 1 3.0|
Amyloid Deposition | 2 1 2 1 3 2 1 3 1 | 26 1.8|
Inflammation, Chronic, Focal | 3 | 3 2.3|
Atrium, Thrombosis | X | 1 |
Ventricle, Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pigmentation | | 1 2.0|
Capsule, Hyperplasia | 2 3 1 2 2 1 2 2 2| 21 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 2 2 3 4 3 3 3 1 | 23 2.7|
Hyperplasia, Focal | 2 | 1 2.0|
Hypertrophy, Focal | 2 | 1 2.0|
Infiltration Cellular, Plasma Cell | 2 | 1 2.0|
Infiltration Cellular, Plasma Cell, | | |
Lymphocyte | 4 | 1 4.0|
Pigmentation | 2 2 3 2 2 2 1 2 2 2 2| 21 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M M M M M M M + + M + M + + M M M M M M + M +| 11 |
Amyloid Deposition | 2 | 2 1.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Hyperplasia, Focal | 2| 1 2.0|
Pars Intermedia, Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + M + + + +| 46 |
Amyloid Deposition | 2 2 4 2 | 18 2.1|
Follicle, Dilatation | | 2 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + + | 3 |
Abscess | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| |
DAY ON TEST | 9| 9| 9| 9| 9| 7| 9| 9| 9| 1| 5| 9| 8| 9| 1| 9| 9| 7| 9| 6| 9| 9| 2| 9| 9| |
| 0| 0| 0| 0| 0| 9| 5| 5| 5| 6| 3| 5| 9| 9| 2| 3| 3| 7| 3| 7| 3| 3| 8| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
Granuloma | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Abscess | | 1 4.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | 3 | 1 3.0|
__________________________________________________________________________|____________|
Penis | + + | 5 |
__________________________________________________________________________|____________|
Preputial Gland | | 1 |
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + M + + +| 47 |
Hyperplasia | 2 | 1 2.0|
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 3 3 3 | 8 3.0|
Fibrosis | 2 | 1 2.0|
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 2 2 1 3 | 9 2.2|
Interstitial Cell, Hyperplasia | | 3 1.3|
Seminiferous Tubule, Degeneration | 1 2 2 1 3 1 2 | 18 1.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Axillary, Hyperplasia | | 1 3.0|
Mediastinal, Hyperplasia | 4 3 | 2 3.5|
Pancreatic, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | 3 | 2 3.5|
Amyloid Deposition | 2 | 2 2.0|
Cyst | X | 2 |
Hyperplasia | 3 3 3 4 3 3 3 4 | 16 3.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + + +| 43 |
Abscess | 3 | 1 3.0|
Amyloid Deposition | 2 2 2 2 2 2 2 1 | 14 2.0|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hemorrhage | | 1 3.0|
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| |
DAY ON TEST | 9| 9| 9| 9| 9| 7| 9| 9| 9| 1| 5| 9| 8| 9| 1| 9| 9| 7| 9| 6| 9| 9| 2| 9| 9| |
| 0| 0| 0| 0| 0| 9| 5| 5| 5| 6| 3| 5| 9| 9| 2| 3| 3| 7| 3| 7| 3| 3| 8| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 2 2 2 2 | 10 2.0|
Hematopoietic Cell Proliferation | 2 2 1 2 3 4 2 1 2 4 4 2 3 4 3 2 2 1 3 3 2 2 4 2 2| 48 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + M + + + M + + + + + + M| 43 |
Cyst | X | 1 |
Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + M M M + + M + M M M M M M M M M + M + M M| 14 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Other, Abscess | 4 4 | 2 4.0|
Other, Acanthosis | 2 3 3 2 3 3 2 | 15 2.5|
Other, Edema | 3 | 1 3.0|
Other, Exudate | X X X X X X X | 14 |
Other, Hyperkeratosis | 2 2 2 | 7 2.0|
Other, Inflammation, Subacute | 3 3 3 4 4 4 4 3 | 15 3.5|
Other, Ulcer | 4 4 4 3 3 4 4 | 16 3.8|
Site of Application-Mass, Acanthosis,| | |
Focal | 4 | 1 4.0|
__________________________________________________________________________|____________|
Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 1 2 | 8 1.8|
Exudate | X | 4 |
Hyperkeratosis | | 1 2.0|
Inflammation, Subacute | 1 2 | 9 1.6|
Ulcer | | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Thalamus, Mineralization, Focal | 1 1 1 2 1 | 9 1.1|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 4 | 2 4.0|
Amyloid Deposition | | 1 2.0|
Atelectasis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97
Route: SKIN APPLICATION Time: 17:20:28
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| |
DAY ON TEST | 9| 9| 9| 9| 9| 7| 9| 9| 9| 1| 5| 9| 8| 9| 1| 9| 9| 7| 9| 6| 9| 9| 2| 9| 9| |
| 0| 0| 0| 0| 0| 9| 5| 5| 5| 6| 3| 5| 9| 9| 2| 3| 3| 7| 3| 7| 3| 3| 8| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| T |
ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A |
ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L |
ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Congestion | 2 2 | 3 2.3|
Hemorrhage | 2 | 1 2.0|
Leukocytosis | 4 3 3 | 6 3.2|
Alveolar Epithelium, Hyperplasia | 2 3 | 2 2.5|
Alveolar Epithelium, Metaplasia, | | |
Focal, Squamous | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 2 | 4 1.8|
Bronchiole, Inflammation, | | |
Proliferative | | 1 3.0|
Interstitium, Inflammation, Chronic, | | |
Focal | 1 2 2 1 3 | 6 2.2|
Interstitium, Inflammation | 3 2 3 2 3 2 | 9 2.6|
Pleura, Fibrosis, Focal | 2 | 1 2.0|
Pleura, Inflammation, Suppurative | 4 | 1 4.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | + + | 2 |
Cornea, Inflammation, Chronic | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 3 | 3 3.3|
Amyloid Deposition | 2 2 2 3 3 1 2 2 2 3 2 | 27 2.5|
Infiltration Cellular, Plasma Cell | 3 3 | 3 3.0|
Nephropathy | 2 2 2 2 3 1 1 1 1| 14 1.9|
Cortex, Cyst | X X| 5 |
Pelvis, Dilatation | 2 3 2 2 2 2 | 11 2.2|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
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