TDMS Study 05120-04 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
BENZYL ACETATE
NTP Experiment-Test: 05120-04 Report: PEIRPT03
Study Type: CHRONIC Date: 09/16/94
Route: DOSED FEED Time: 03:33:00
Facility: Southern Research Institute
Chemical CAS #: 140-11-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94
Route: DOSED FEED Time: 03:33:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0% .033% .1% .3%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund Sacrifice 12 16 7 3
Natural Death 9 6 6 3
Survivors
Terminal Sacrifice 29 28 37 44
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (60) (58) (58) (60)
Dilatation 2 (3%) 1 (2%)
Inflammation, Subacute 1 (2%)
Intestine Large, Cecum (59) (60) (60) (58)
Edema 1 (2%)
Intestine Small, Duodenum (59) (58) (59) (59)
Dilatation 1 (2%)
Intestine Small, Ileum (58) (58) (59) (59)
Hyperplasia, Lymphoid 1 (2%)
Intestine Small, Jejunum (58) (60) (59) (59)
Dilatation 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (3%)
Liver (60) (60) (60) (60)
Angiectasis 2 (3%) 2 (3%)
Basophilic Focus 4 (7%) 2 (3%) 5 (8%)
Clear Cell Focus 2 (3%) 2 (3%) 2 (3%)
Cyst 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 13 (22%) 7 (12%) 10 (17%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Focal 2 (3%) 2 (3%) 2 (3%)
Hyperplasia, Lymphoid 3 (5%) 5 (8%) 5 (8%) 2 (3%)
Inflammation, Subacute 12 (20%) 4 (7%) 7 (12%) 13 (22%)
Metaplasia, Osseous 1 (2%)
Mineralization 1 (2%) 1 (2%)
Mixed Cell Focus 2 (3%) 2 (3%) 1 (2%)
Nuclear Alteration 3 (5%)
Bile Duct, Hyperplasia 2 (3%)
Centrilobular, Necrosis 1 (2%)
Hepatocyte, Cytomegaly 1 (2%)
Hepatocyte, Karyomegaly 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 3 (5%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94
Route: DOSED FEED Time: 03:33:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0% .033% .1% .3%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Kupffer Cell, Hyperplasia 7 (12%) 6 (10%) 11 (18%) 5 (8%)
Kupffer Cell, Pigmentation 2 (3%) 5 (8%) 2 (3%)
Lobules, Necrosis 7 (12%) 8 (13%) 4 (7%) 6 (10%)
Mesentery (9) (7) (7) (3)
Inflammation, Suppurative 3 (33%) 3 (43%) 4 (57%) 1 (33%)
Capillary, Fat, Congestion 1 (33%)
Fat, Necrosis 2 (22%) 2 (29%) 1 (14%)
Pancreas (60) (60) (60) (59)
Atrophy 4 (7%) 5 (8%) 2 (3%)
Cyst 1 (2%) 4 (7%) 1 (2%)
Focal Cellular Change 2 (3%)
Hyperplasia, Lymphoid 4 (7%) 2 (3%) 8 (13%) 4 (7%)
Necrosis 2 (3%)
Acinar Cell, Cytoplasmic Alteration 8 (13%) 2 (3%) 3 (5%)
Salivary Glands (60) (60) (60) (60)
Atrophy 1 (2%)
Hyperplasia, Lymphoid 11 (18%) 13 (22%) 13 (22%) 15 (25%)
Stomach, Forestomach (59) (60) (60) (60)
Diverticulum 2 (3%) 2 (3%) 2 (3%)
Edema 1 (2%) 1 (2%)
Inflammation, Subacute 4 (7%) 7 (12%) 2 (3%)
Ulcer 2 (3%)
Mucosa, Hyperplasia 8 (14%) 6 (10%) 9 (15%) 3 (5%)
Stomach, Glandular (60) (60) (60) (60)
Cyst 6 (10%) 3 (5%) 3 (5%) 2 (3%)
Edema 1 (2%) 1 (2%)
Erosion 4 (7%) 1 (2%) 1 (2%)
Inflammation, Chronic 2 (3%)
Inflammation, Subacute 1 (2%) 1 (2%) 1 (2%)
Ulcer 1 (2%)
Mucosa, Dysplasia 1 (2%)
Tongue (60) (60) (60) (60)
Inflammation, Chronic 1 (2%) 3 (5%) 2 (3%)
Mineralization 1 (2%)
Tooth (1)
Dysplasia 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2) (2) (5)
Inflammation, Chronic Active 2 (100%) 2 (100%) 5 (100%)
Heart (60) (60) (60) (60)
Cardiomyopathy 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Myocardium, Inflammation, Chronic 2 (3%) 2 (3%)
Myocardium, Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94
Route: DOSED FEED Time: 03:33:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0% .033% .1% .3%
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (60) (60) (60)
Accessory Adrenal Cortical Nodule 17 (28%) 6 (10%) 14 (23%) 14 (23%)
Angiectasis 1 (2%) 1 (2%)
Cyst 2 (3%) 2 (3%)
Developmental Malformation 1 (2%)
Hematopoietic Cell Proliferation 3 (5%) 2 (3%) 4 (7%)
Hyperplasia, Diffuse 1 (2%) 1 (2%)
Hyperplasia, Focal 1 (2%) 1 (2%) 1 (2%)
Hypertrophy, Focal 1 (2%) 2 (3%)
Inflammation, Subacute 1 (2%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Capsule, Hyperplasia 1 (2%) 1 (2%) 5 (8%) 5 (8%)
X-Zone, Degeneration, Fatty 1 (2%) 1 (2%)
Adrenal Gland, Medulla (60) (60) (60) (60)
Hyperplasia 2 (3%) 4 (7%) 5 (8%) 3 (5%)
Islets, Pancreatic (60) (60) (60) (59)
Hyperplasia 5 (8%) 1 (2%)
Parathyroid Gland (56) (60) (57) (55)
Cyst 2 (4%) 1 (2%) 1 (2%)
Ectopic Thymus 1 (2%) 2 (4%)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (57) (56) (60) (59)
Pars Distalis, Angiectasis 5 (9%) 4 (7%) 6 (10%)
Pars Distalis, Cyst 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 18 (32%) 14 (25%) 15 (25%) 14 (24%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (60) (60) (60) (60)
Degeneration, Cystic 10 (17%) 9 (15%) 14 (23%) 13 (22%)
Ectopic Thymus 2 (3%) 1 (2%)
Inflammation, Subacute 1 (2%)
Follicle, Cyst 5 (8%) 3 (5%) 2 (3%) 5 (8%)
Follicular Cell, Hyperplasia 11 (18%) 10 (17%) 12 (20%) 17 (28%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1) (1)
Infiltration Cellular, Lymphocyte 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94
Route: DOSED FEED Time: 03:33:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0% .033% .1% .3%
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (1) (1) (1)
Ectasia 1 (100%)
Pigmentation 1 (100%) 1 (100%)
Ovary (59) (58) (59) (59)
Angiectasis 8 (14%) 8 (14%) 9 (15%) 5 (8%)
Cyst 11 (19%) 14 (24%) 16 (27%) 17 (29%)
Hemorrhage 1 (2%) 2 (3%) 1 (2%) 1 (2%)
Inflammation, Suppurative 13 (22%) 7 (12%) 10 (17%) 4 (7%)
Pigmentation 1 (2%) 2 (3%)
Thrombosis 1 (2%)
Interstitial Cell, Hyperplasia 4 (7%) 1 (2%) 1 (2%)
Uterus (60) (59) (60) (60)
Angiectasis 2 (3%) 2 (3%) 3 (5%) 3 (5%)
Granuloma 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hydrometra 1 (2%) 3 (5%) 4 (7%) 2 (3%)
Hyperplasia, Cystic 56 (93%) 55 (93%) 58 (97%) 58 (97%)
Inflammation, Suppurative 14 (23%) 6 (10%) 10 (17%) 6 (10%)
Necrosis 1 (2%) 2 (3%)
Endometrium, Pigmentation 1 (2%) 1 (2%)
Epithelium, Metaplasia, Squamous 7 (12%) 8 (14%) 15 (25%) 7 (12%)
Myometrium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Vagina (1)
Granuloma 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Hypercellularity 19 (32%) 11 (18%) 20 (33%) 8 (13%)
Myelofibrosis 16 (27%) 12 (20%) 14 (23%) 15 (25%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 3 (5%) 2 (3%) 7 (12%) 4 (7%)
Lymph Node (60) (60) (60) (59)
Iliac, Angiectasis 1 (2%)
Iliac, Hematopoietic Cell Proliferation 2 (3%)
Iliac, Hyperplasia, Lymphoid 2 (3%)
Iliac, Hyperplasia, Plasma Cell 2 (3%) 3 (5%) 1 (2%)
Lumbar, Hyperplasia, Lymphoid 1 (2%)
Lumbar, Hyperplasia, Plasma Cell 2 (3%)
Mediastinal, Hyperplasia, Plasma Cell 5 (8%) 4 (7%) 2 (3%)
Mediastinal, Inflammation, Suppurative 1 (2%) 2 (3%)
Renal, Ectasia 1 (2%)
Renal, Hematopoietic Cell Proliferation 2 (3%) 1 (2%)
Renal, Hemorrhage 1 (2%)
Renal, Hyperplasia, Lymphoid 3 (5%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94
Route: DOSED FEED Time: 03:33:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0% .033% .1% .3%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Renal, Hyperplasia, Plasma Cell 5 (8%) 5 (8%) 3 (5%) 1 (2%)
Lymph Node, Mandibular (60) (58) (60) (59)
Hematopoietic Cell Proliferation 2 (3%) 1 (2%) 2 (3%)
Hyperplasia, Lymphoid 5 (8%) 5 (9%) 5 (8%)
Hyperplasia, Plasma Cell 6 (10%) 4 (7%) 1 (2%) 1 (2%)
Pigmentation 1 (2%) 2 (3%) 1 (2%)
Lymph Node, Mesenteric (60) (56) (59) (58)
Angiectasis 2 (3%) 1 (2%)
Ectasia 2 (3%)
Hematopoietic Cell Proliferation 11 (18%) 5 (9%) 4 (7%) 2 (3%)
Hemorrhage 7 (12%) 3 (5%) 5 (8%) 6 (10%)
Hyperplasia, Lymphoid 3 (5%) 3 (5%) 3 (5%) 3 (5%)
Hyperplasia, Plasma Cell 2 (3%) 1 (2%)
Necrosis 1 (2%)
Spleen (60) (60) (60) (59)
Hematopoietic Cell Proliferation 27 (45%) 24 (40%) 27 (45%) 15 (25%)
Hyperplasia, Reticulum Cell 2 (3%)
Pigmentation, Hemosiderin 8 (13%) 7 (12%) 6 (10%) 2 (3%)
Lymphoid Follicle, Atrophy 1 (2%) 1 (2%) 1 (2%)
Lymphoid Follicle, Hyperplasia 4 (7%) 6 (10%) 6 (10%) 6 (10%)
Red Pulp, Hyperplasia 3 (5%) 1 (2%) 1 (2%) 1 (2%)
Thymus (55) (56) (56) (57)
Angiectasis 4 (7%) 2 (4%) 1 (2%)
Cyst 9 (16%) 3 (5%) 11 (20%) 13 (23%)
Depletion Cellular 8 (15%) 9 (16%) 6 (11%) 2 (4%)
Ectopic Parathyroid Gland 2 (4%)
Hyperplasia, Lymphoid 3 (5%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (59) (60) (60)
Hyperplasia, Cystic 5 (8%) 4 (7%) 2 (3%)
Hyperplasia, Lobular 1 (2%) 1 (2%)
Skin (60) (60) (59) (60)
Acanthosis 2 (3%) 1 (2%) 4 (7%) 3 (5%)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Chronic 3 (5%) 1 (2%) 3 (5%) 2 (3%)
Ulcer 1 (2%) 1 (2%)
Subcutaneous Tissue, Edema 2 (3%) 2 (3%) 2 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94
Route: DOSED FEED Time: 03:33:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0% .033% .1% .3%
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (60) (60) (60) (60)
Foreign Body 1 (2%)
Inflammation, Chronic 7 (12%) 2 (3%) 7 (12%) 1 (2%)
Sarcolemmal Nuclei, Hyperplasia 1 (2%) 1 (2%) 4 (7%)
Sarcoplasm, Atrophy 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Compression 3 (5%) 3 (5%) 1 (2%)
Cyst 1 (2%)
Hydrocephalus 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Glial Cell, Proliferation 1 (2%)
Thalamus, Mineralization 38 (63%) 53 (88%) 47 (78%) 42 (70%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Adenomatosis 1 (2%)
Bacterium 1 (2%) 1 (2%) 1 (2%)
Congestion 1 (2%)
Edema 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 6 (10%) 4 (7%) 4 (7%)
Hyperplasia, Lymphoid 9 (15%) 7 (12%) 10 (17%) 14 (23%)
Infiltration Cellular, Histiocyte 7 (12%) 4 (7%) 3 (5%) 1 (2%)
Inflammation, Subacute 1 (2%) 3 (5%)
Inflammation, Suppurative 2 (3%)
Thrombosis 2 (3%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Artery, Hypertrophy 1 (2%) 1 (2%)
Bronchiole, Foreign Body 1 (2%) 3 (5%) 1 (2%)
Nose (60) (60) (60) (60)
Exudate 15 (25%) 26 (43%) 36 (60%) 45 (75%)
Glands, Cyst 1 (2%)
Glands, Hyperplasia, Cystic 47 (78%) 54 (90%) 59 (98%) 60 (100%)
Mucosa, Atrophy 46 (77%) 57 (95%) 59 (98%) 60 (100%)
Mucosa, Degeneration 58 (97%) 57 (95%) 60 (100%) 60 (100%)
Mucosa, Pigmentation 53 (88%) 58 (97%) 58 (97%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94
Route: DOSED FEED Time: 03:33:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0% .033% .1% .3%
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Bacterium 1 (2%) 1 (2%) 1 (2%)
Casts Protein 39 (65%) 39 (65%) 38 (63%) 31 (52%)
Cyst 2 (3%) 2 (3%) 2 (3%)
Glomerulosclerosis 7 (12%) 5 (8%) 1 (2%)
Hydronephrosis 1 (2%)
Hyperplasia, Lymphoid 28 (47%) 27 (45%) 22 (37%) 23 (38%)
Inflammation, Suppurative 5 (8%)
Metaplasia, Osseous 2 (3%) 2 (3%)
Mineralization 2 (3%) 1 (2%) 3 (5%)
Interstitial Tissue, Pigmentation 2 (3%)
Renal Tubule, Atrophy 2 (3%) 1 (2%) 1 (2%)
Renal Tubule, Cytoplasmic Alteration 1 (2%)
Renal Tubule, Dilatation 6 (10%) 1 (2%) 2 (3%)
Renal Tubule, Necrosis 1 (2%) 1 (2%)
Renal Tubule, Pigmentation 1 (2%) 2 (3%)
Renal Tubule, Regeneration 22 (37%) 9 (15%) 15 (25%) 14 (23%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (60) (59) (60) (60)
Edema 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 24 (40%) 15 (25%) 22 (37%) 17 (28%)
Inflammation, Chronic 1 (2%)
Mucosa, Hyperplasia 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94
Route: DOSED FEED Time: 03:33:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0% .033% .1% .3%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund Sacrifice 7 3 6 7
Natural Death 4 4 3 4
Survivors
Terminal Sacrifice 39 43 41 39
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (57) (60) (58) (60)
Cyst 1 (2%)
Inflammation, Subacute 1 (2%) 1 (2%)
Mucosa, Hyperplasia 1 (2%) 1 (2%)
Intestine Large, Cecum (59) (58) (60) (58)
Edema 1 (2%)
Intestine Small, Ileum (58) (59) (60) (58)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Intestine Small, Jejunum (60) (59) (60) (59)
Hyperplasia, Lymphoid 2 (3%) 1 (2%) 1 (2%)
Liver (60) (60) (60) (60)
Basophilic Focus 2 (3%) 2 (3%) 2 (3%)
Clear Cell Focus 7 (12%) 4 (7%) 5 (8%) 2 (3%)
Hematopoietic Cell Proliferation 2 (3%) 1 (2%) 1 (2%)
Hyperplasia, Focal 2 (3%) 3 (5%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Inflammation, Subacute 1 (2%) 3 (5%) 2 (3%) 3 (5%)
Mixed Cell Focus 3 (5%) 2 (3%) 2 (3%) 2 (3%)
Nuclear Alteration 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Centrilobular, Necrosis 1 (2%) 2 (3%) 1 (2%) 1 (2%)
Hepatocyte, Cytomegaly 2 (3%) 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 4 (7%) 1 (2%) 2 (3%) 2 (3%)
Kupffer Cell, Hyperplasia 3 (5%) 2 (3%) 2 (3%) 4 (7%)
Kupffer Cell, Pigmentation 1 (2%) 2 (3%)
Lobules, Necrosis 4 (7%) 1 (2%) 2 (3%) 4 (7%)
Mesentery (3) (3) (2) (1)
Inflammation, Suppurative 1 (33%)
Fat, Hemorrhage 1 (33%)
Fat, Necrosis 2 (67%) 1 (33%) 2 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94
Route: DOSED FEED Time: 03:33:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0% .033% .1% .3%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (60) (60) (60) (60)
Atrophy 2 (3%) 2 (3%) 2 (3%)
Cyst 1 (2%)
Focal Cellular Change 3 (5%) 2 (3%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Acinar Cell, Cytoplasmic Alteration 3 (5%) 2 (3%) 5 (8%)
Acinar Cell, Hyperplasia, Focal 1 (2%)
Pharynx (1)
Ulcer 1 (100%)
Salivary Glands (60) (60) (60) (60)
Hyperplasia, Lymphoid 8 (13%) 4 (7%) 5 (8%) 7 (12%)
Stomach, Forestomach (60) (60) (60) (60)
Diverticulum 3 (5%) 3 (5%)
Erosion 1 (2%)
Inflammation, Subacute 3 (5%) 3 (5%) 3 (5%) 1 (2%)
Mucosa, Hyperplasia 5 (8%) 4 (7%) 5 (8%) 3 (5%)
Stomach, Glandular (60) (60) (60) (60)
Cyst 5 (8%) 6 (10%) 2 (3%) 6 (10%)
Erosion 3 (5%)
Ulcer 1 (2%)
Tongue (60) (60) (60) (60)
Inflammation, Chronic 1 (2%)
Epithelium, Degeneration, Ballooning 1 (2%)
Tooth (3) (4) (1) (2)
Dysplasia 3 (100%) 3 (75%) 1 (100%) 2 (100%)
Inflammation, Chronic 1 (25%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1) (2) (1)
Inflammation, Chronic Active 1 (100%) 1 (100%) 2 (100%) 1 (100%)
Heart (60) (60) (60) (60)
Cardiomyopathy 2 (3%)
Myocardium, Hemorrhage 1 (2%)
Myocardium, Inflammation, Chronic 2 (3%)
Myocardium, Mineralization 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (60) (60) (60)
Accessory Adrenal Cortical Nodule 9 (15%) 10 (17%) 8 (13%) 8 (13%)
Angiectasis 1 (2%) 1 (2%)
Cyst 1 (2%)
Hyperplasia, Diffuse 1 (2%)
Hyperplasia, Focal 7 (12%) 13 (22%) 8 (13%) 7 (12%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94
Route: DOSED FEED Time: 03:33:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0% .033% .1% .3%
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hypertrophy, Focal 29 (48%) 22 (37%) 23 (38%) 26 (43%)
Vacuolization Cytoplasmic, Focal 5 (8%) 4 (7%) 2 (3%) 5 (8%)
Capsule, Hyperplasia 11 (18%) 8 (13%) 9 (15%) 7 (12%)
Adrenal Gland, Medulla (60) (60) (60) (60)
Hyperplasia 2 (3%) 1 (2%) 1 (2%)
Islets, Pancreatic (60) (60) (59) (60)
Cyst 1 (2%)
Hyperplasia 11 (18%) 13 (22%) 11 (19%) 4 (7%)
Parathyroid Gland (52) (58) (55) (59)
Cyst 1 (2%) 2 (3%) 2 (4%)
Ectopic Thymus 1 (2%)
Pituitary Gland (58) (59) (58) (57)
Pars Distalis, Cyst 4 (7%) 1 (2%) 3 (5%)
Pars Distalis, Hyperplasia 2 (3%) 1 (2%) 2 (3%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (60) (60) (60) (60)
Degeneration, Cystic 5 (8%) 4 (7%) 8 (13%) 8 (13%)
Follicle, Cyst 6 (10%) 2 (3%) 3 (5%) 5 (8%)
Follicular Cell, Hyperplasia 6 (10%) 8 (13%) 7 (12%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1)
Dilatation 1 (100%)
Epididymis (60) (60) (60) (60)
Atypia Cellular 1 (2%) 1 (2%) 2 (3%) 2 (3%)
Hypospermia 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Spermatocele 1 (2%)
Preputial Gland (38) (42) (35) (25)
Atrophy 1 (3%)
Ectasia 33 (87%) 40 (95%) 32 (91%) 24 (96%)
Inflammation, Chronic 18 (47%) 25 (60%) 18 (51%) 11 (44%)
Inflammation, Suppurative 3 (8%) 4 (10%) 1 (3%)
Prostate (60) (60) (60) (60)
Fibrosis 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 4 (7%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Seminal Vesicle (60) (60) (60) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94
Route: DOSED FEED Time: 03:33:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0% .033% .1% .3%
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Depletion Cellular 1 (2%)
Dilatation 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Testes (60) (60) (60) (60)
Angiectasis 1 (2%)
Granuloma Sperm 2 (3%)
Mineralization 1 (2%)
Seminiferous Tubule, Atrophy 1 (2%) 3 (5%) 6 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Hypercellularity 8 (13%) 6 (10%) 3 (5%) 4 (7%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 2 (3%) 1 (2%) 2 (3%)
Lymph Node (60) (60) (60) (60)
Inguinal, Hyperplasia, Lymphoid 2 (3%) 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Mediastinal, Hyperplasia, Plasma Cell 2 (3%)
Lymph Node, Mandibular (58) (56) (60) (59)
Depletion Cellular 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 3 (5%) 4 (7%)
Hyperplasia, Plasma Cell 3 (5%) 1 (2%) 1 (2%)
Pigmentation 2 (3%)
Lymph Node, Mesenteric (58) (59) (60) (60)
Angiectasis 1 (2%)
Depletion Cellular 1 (2%)
Ectasia 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 3 (5%) 5 (8%) 8 (13%) 1 (2%)
Hemorrhage 18 (31%) 24 (41%) 19 (32%) 23 (38%)
Hyperplasia, Lymphoid 4 (7%) 5 (8%) 1 (2%) 4 (7%)
Hyperplasia, Plasma Cell 1 (2%) 1 (2%) 1 (2%)
Necrosis 1 (2%)
Pigmentation 1 (2%) 1 (2%)
Spleen (60) (60) (60) (60)
Hematopoietic Cell Proliferation 13 (22%) 14 (23%) 9 (15%) 8 (13%)
Hyperplasia, Reticulum Cell 1 (2%)
Necrosis 1 (2%)
Lymphoid Follicle, Atrophy 1 (2%) 1 (2%) 1 (2%) 3 (5%)
Lymphoid Follicle, Hyperplasia 1 (2%) 1 (2%) 1 (2%) 3 (5%)
Red Pulp, Atrophy 1 (2%) 1 (2%) 1 (2%)
Red Pulp, Hyperplasia 1 (2%)
Thymus (52) (55) (57) (54)
Cyst 12 (23%) 12 (22%) 15 (26%) 10 (19%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94
Route: DOSED FEED Time: 03:33:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0% .033% .1% .3%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Depletion Cellular 4 (8%) 4 (7%) 4 (7%) 5 (9%)
Ectopic Parathyroid Gland 1 (2%)
Hyperplasia, Lymphoid 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (60) (60) (60)
Acanthosis 2 (3%) 1 (2%) 2 (3%)
Granuloma 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 2 (3%) 1 (2%)
Subcutaneous Tissue, Edema 1 (2%) 1 (2%) 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Dysplasia 1 (2%)
Hyperostosis 2 (3%)
Skeletal Muscle (60) (60) (60) (60)
Inflammation, Chronic 1 (2%) 3 (5%) 2 (3%)
Sarcolemmal Nuclei, Hyperplasia 1 (2%) 2 (3%) 1 (2%) 2 (3%)
Sarcoplasm, Atrophy 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Compression 1 (2%)
Ectopic Tissue 1 (2%)
Hydrocephalus 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Glial Cell, Proliferation 1 (2%)
Thalamus, Mineralization 46 (77%) 48 (80%) 54 (90%) 47 (78%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Angiectasis 1 (2%)
Congestion 1 (2%)
Hemorrhage 2 (3%) 2 (3%) 5 (8%)
Hyperplasia, Lymphoid 5 (8%) 2 (3%) 2 (3%)
Infiltration Cellular, Histiocyte 7 (12%) 8 (13%) 8 (13%) 4 (7%)
Inflammation, Suppurative 1 (2%)
Thrombosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05120-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/16/94
Route: DOSED FEED Time: 03:33:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0% .033% .1% .3%
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolar Epithelium, Hyperplasia 1 (2%) 3 (5%) 6 (10%) 1 (2%)
Nose (60) (60) (60) (60)
Cyst 1 (2%)
Developmental Malformation 1 (2%)
Exudate 8 (13%) 18 (30%) 39 (65%) 31 (52%)
Glands, Hyperplasia, Cystic 24 (40%) 46 (77%) 48 (80%) 60 (100%)
Mucosa, Atrophy 30 (50%) 57 (95%) 60 (100%) 60 (100%)
Mucosa, Degeneration 36 (60%) 55 (92%) 60 (100%) 60 (100%)
Mucosa, Metaplasia, Squamous 1 (2%)
Mucosa, Pigmentation 52 (87%) 60 (100%) 60 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (1)
Inflammation, Chronic 3 (100%) 1 (100%)
Cornea, Hyperplasia 3 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Casts Protein 10 (17%) 16 (27%) 13 (22%) 7 (12%)
Cyst 21 (35%) 16 (27%) 16 (27%) 17 (28%)
Glomerulosclerosis 1 (2%) 4 (7%) 1 (2%) 2 (3%)
Hyperplasia, Lymphoid 18 (30%) 17 (28%) 15 (25%) 12 (20%)
Inflammation, Suppurative 2 (3%)
Mineralization 29 (48%) 48 (80%) 42 (70%) 38 (63%)
Renal Tubule, Atrophy 6 (10%) 3 (5%) 5 (8%) 2 (3%)
Renal Tubule, Dilatation 2 (3%) 1 (2%) 1 (2%) 2 (3%)
Renal Tubule, Hyperplasia 2 (3%) 1 (2%) 1 (2%)
Renal Tubule, Pigmentation 1 (2%)
Renal Tubule, Regeneration 57 (95%) 51 (85%) 47 (78%) 51 (85%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
Urinary Bladder (60) (60) (60) (60)
Dilatation 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 2 (3%) 2 (3%) 2 (3%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 2 (3%)
Mucosa, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
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