TDMS Study 05120-04 Pathology Tables
NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 Facility: Southern Research Institute Chemical CAS #: 140-11-4 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 4| 6| 5| 6| DAY ON TEST | 2| 5| 5| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 4| 2| 9| 2| 5| 2| 2| 2| 5| 5| 4| 0| | 9| 6| 6| 2| 9| 9| 9| 9| 6| 9| 9| 9| 9| 1| 9| 1| 9| 6| 9| 9| 9| 6| 9| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + M + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + A + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + A + + + + + + + + + + + M + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + + + + + + + A + + + + + + + + + + +| Carcinoma | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X | Hepatocellular Carcinoma, Multiple, | | Two | | Hepatocellular Carcinoma, Multiple, | | Five | | Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple, Two| | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Mesentery | + + + +| Carcinoma, Metastatic, Pancreas | | Carcinoma, Metastatic, Intestine | | Small | X | Hemangioma | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + I + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | | __________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 4| 6| 5| 6| DAY ON TEST | 2| 5| 5| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 4| 2| 9| 2| 5| 2| 2| 2| 5| 5| 4| 0| | 9| 6| 6| 2| 9| 9| 9| 9| 6| 9| 9| 9| 9| 1| 9| 1| 9| 6| 9| 9| 9| 6| 9| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Hepatocellular Carcinoma, Metastatic,| | Liver | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + + + + + + M + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + M + + + M + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | | Granulosa Cell Tumor Benign | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X X X | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Axillary, Hepatocellular Carcinoma, | | Metastatic, Liver | | Bronchial, Lymphoma Malignant | | Lymphocytic | | Iliac, Lymphoma Malignant Mixed | | Mediastinal, Carcinoma, Metastatic, | | Pancreas | | Mediastinal, Hepatocellular | | Carcinoma, Metastatic, Liver | | Mediastinal, Lymphoma Malignant Mixed| X | Pancreatic, Lymphoma Malignant | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 4| 6| 5| 6| DAY ON TEST | 2| 5| 5| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 4| 2| 9| 2| 5| 2| 2| 2| 5| 5| 4| 0| | 9| 6| 6| 2| 9| 9| 9| 9| 6| 9| 9| 9| 9| 1| 9| 1| 9| 6| 9| 9| 9| 6| 9| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphocytic | | Pancreatic, Lymphoma Malignant Mixed | X X | Renal, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X X | __________________________________________________________________________| Thymus | + + M M + + + + + + + + + + + + + + + + + + + + M| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | Thymoma Benign | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangioma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Carcinoma, Metastatic, Pancreas | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 5| 7| 6| 7| 4| 7| 7| 7| 4| 6| 5| 6| DAY ON TEST | 2| 5| 5| 2| 2| 2| 2| 2| 5| 3| 2| 2| 2| 4| 2| 9| 2| 5| 2| 2| 2| 5| 5| 4| 0| | 9| 6| 6| 2| 9| 9| 9| 9| 6| 9| 9| 9| 9| 1| 9| 1| 9| 6| 9| 9| 9| 6| 9| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Harderian Gland | + + | Adenoma | X X | __________________________________________________________________________| Lacrimal Gland | M | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | | Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X X X | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 4| 7| 7| 4| 6| 5| 4| 5| 4| 4| 7| 7| 4| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 5| 2| 2| 5| 0| 8| 5| 3| 9| 5| 2| 2| 5| 3| 2| 2| 2| 1| 2| 9| 2| 2| 2| 2| 2| | 7| 9| 9| 7| 0| 4| 8| 3| 4| 8| 9| 9| 8| 3| 9| 9| 0| 4| 9| 7| 9| 5| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X X X X | Hepatocellular Carcinoma, Multiple, | | Two | X | Hepatocellular Carcinoma, Multiple, | | Five | | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple, Two| | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Mesentery | + + + + | Carcinoma, Metastatic, Pancreas | X | Carcinoma, Metastatic, Intestine | | Small | | Hemangioma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | X | __________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | X | _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 4| 7| 7| 4| 6| 5| 4| 5| 4| 4| 7| 7| 4| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 5| 2| 2| 5| 0| 8| 5| 3| 9| 5| 2| 2| 5| 3| 2| 2| 2| 1| 2| 9| 2| 2| 2| 2| 2| | 7| 9| 9| 7| 0| 4| 8| 3| 4| 8| 9| 9| 8| 3| 9| 9| 0| 4| 9| 7| 9| 5| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + M + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X X| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | | __________________________________________________________________________| Ovary | + + + + + + + + M + + + + + + + + + + + + + + + +| Cystadenoma | X | Granulosa Cell Tumor Benign | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X X X | __________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Axillary, Hepatocellular Carcinoma, | | Metastatic, Liver | X | Bronchial, Lymphoma Malignant | | Lymphocytic | X | Iliac, Lymphoma Malignant Mixed | X | Mediastinal, Carcinoma, Metastatic, | | Pancreas | X | Mediastinal, Hepatocellular | | Carcinoma, Metastatic, Liver | X | Mediastinal, Lymphoma Malignant Mixed| X X | Pancreatic, Lymphoma Malignant | | _____________________________________________________________________________________________________________________| Page 7 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 4| 7| 7| 4| 6| 5| 4| 5| 4| 4| 7| 7| 4| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 5| 2| 2| 5| 0| 8| 5| 3| 9| 5| 2| 2| 5| 3| 2| 2| 2| 1| 2| 9| 2| 2| 2| 2| 2| | 7| 9| 9| 7| 0| 4| 8| 3| 4| 8| 9| 9| 8| 3| 9| 9| 0| 4| 9| 7| 9| 5| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphocytic | X | Pancreatic, Lymphoma Malignant Mixed | | Renal, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X X | __________________________________________________________________________| Thymus | + + + + + + + M + + + + + + + + + + + M + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X | Thymoma Benign | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangioma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pancreas | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Carcinoma, Metastatic, Pancreas | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | M | _____________________________________________________________________________________________________________________| Page 8 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 4| 7| 7| 4| 6| 5| 4| 5| 4| 4| 7| 7| 4| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 5| 2| 2| 5| 0| 8| 5| 3| 9| 5| 2| 2| 5| 3| 2| 2| 2| 1| 2| 9| 2| 2| 2| 2| 2| | 7| 9| 9| 7| 0| 4| 8| 3| 4| 8| 9| 9| 8| 3| 9| 9| 0| 4| 9| 7| 9| 5| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | __________________________________________________________________________| Lacrimal Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | X | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X X | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 4| 7| 6| 7| 4| 5| | | DAY ON TEST | 3| 2| 2| 2| 5| 2| 7| 2| 5| 9| | | | 3| 9| 9| 9| 8| 9| 5| 9| 8| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 58 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 58 | Carcinoma | | 1 | Lymphoma Malignant Mixed | | 3 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Hepatocellular Carcinoma | X | 8 | Hepatocellular Carcinoma, Multiple, | | | Two | | 1 | Hepatocellular Carcinoma, Multiple, | | | Five | X | 1 | Hepatocellular Adenoma | | 6 | Hepatocellular Adenoma, Multiple, Two| X | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Mesentery | + | 9 | Carcinoma, Metastatic, Pancreas | | 1 | Carcinoma, Metastatic, Intestine | | | Small | | 1 | Hemangioma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Carcinoma | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Carcinoma, Metastatic, Pancreas | | 1 | __________________________________________________________________________|____________| Tongue | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 4| 7| 6| 7| 4| 5| | | DAY ON TEST | 3| 2| 2| 2| 5| 2| 7| 2| 5| 9| | | | 3| 9| 9| 9| 8| 9| 5| 9| 8| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 2 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Carcinoma, Metastatic, Pancreas | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + | 60 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | Adenoma | X | 3 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 56 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 57 | Pars Distalis, Adenoma | X | 9 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | Follicular Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 59 | Cystadenoma | | 1 | Granulosa Cell Tumor Benign | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 60 | Polyp Stromal | | 8 | __________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 3 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 60 | Axillary, Hepatocellular Carcinoma, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 4| 7| 6| 7| 4| 5| | | DAY ON TEST | 3| 2| 2| 2| 5| 2| 7| 2| 5| 9| | | | 3| 9| 9| 9| 8| 9| 5| 9| 8| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Metastatic, Liver | | 1 | Bronchial, Lymphoma Malignant | | | Lymphocytic | | 1 | Iliac, Lymphoma Malignant Mixed | | 1 | Mediastinal, Carcinoma, Metastatic, | | | Pancreas | | 1 | Mediastinal, Hepatocellular | | | Carcinoma, Metastatic, Liver | | 1 | Mediastinal, Lymphoma Malignant Mixed| | 3 | Pancreatic, Lymphoma Malignant | | | Lymphocytic | | 1 | Pancreatic, Lymphoma Malignant Mixed | | 2 | Renal, Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 60 | Carcinoma, Metastatic, Pancreas | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 6 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 6 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 55 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 4 | Thymoma Benign | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Subcutaneous Tissue, Hemangioma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + | 60 | Carcinoma, Metastatic, Pancreas | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 7| 4| 7| 6| 7| 4| 5| | | DAY ON TEST | 3| 2| 2| 2| 5| 2| 7| 2| 5| 9| | | | 3| 9| 9| 9| 8| 9| 5| 9| 8| 7| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma | | 1 | Carcinoma, Metastatic, Pancreas | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | | __________________________________________________________________________|____________| Harderian Gland | | 3 | Adenoma | | 3 | __________________________________________________________________________|____________| Lacrimal Gland | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Renal Tubule, Adenoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 4| 7| 6| 7| 6| 7| 7| 4| 7| 5| 6| 7| 4| 7| 7| 7| 5| 0| 7| 7| 4| 7| 7| 4| 7| DAY ON TEST | 5| 3| 5| 3| 7| 3| 3| 5| 3| 0| 4| 3| 2| 3| 3| 3| 4| 1| 3| 3| 5| 1| 3| 5| 3| | 6| 2| 9| 2| 8| 2| 2| 6| 2| 7| 7| 2| 8| 2| 2| 2| 4| 7| 2| 2| 7| 8| 2| 7| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| .033% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + I + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + M + + + + + + + +| Carcinoma | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X | Hepatocellular Adenoma | X X X | Hepatocellular Adenoma, Multiple, Two| | Histiocytic Sarcoma, Metastatic, | | Uterus | | Lymphoma Malignant Lymphocytic | X | Sarcoma Stromal, Metastatic, Uterus | X | __________________________________________________________________________| Mesentery | + + + + + | Fibrous Histiocytoma | | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 4| 7| 6| 7| 6| 7| 7| 4| 7| 5| 6| 7| 4| 7| 7| 7| 5| 0| 7| 7| 4| 7| 7| 4| 7| DAY ON TEST | 5| 3| 5| 3| 7| 3| 3| 5| 3| 0| 4| 3| 2| 3| 3| 3| 4| 1| 3| 3| 5| 1| 3| 5| 3| | 6| 2| 9| 2| 8| 2| 2| 6| 2| 7| 7| 2| 8| 2| 2| 2| 4| 7| 2| 2| 7| 8| 2| 7| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| .033% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | | __________________________________________________________________________| Ovary | + + + + M + + + + + + I + + + + + + + + + + + + +| Choriocarcinoma | X | Histiocytic Sarcoma, Metastatic, | | Uterus | | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Uterus | + + + + M + + + + + + + + + + + + + + + + + + + +| Carcinoma In Situ | | Hemangioma | | Histiocytic Sarcoma | | Leiomyosarcoma | X | Lymphoma Malignant Lymphocytic | X | Polyp Stromal | X | Sarcoma Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma, Metastatic, Skin | | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Axillary, Lymphoma Malignant | | Lymphocytic | X | Iliac, Lymphoma Malignant Lymphocytic| X | Inguinal, Lymphoma Malignant | | Lymphocytic | X | Lumbar, Lymphoma Malignant | | _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 4| 7| 6| 7| 6| 7| 7| 4| 7| 5| 6| 7| 4| 7| 7| 7| 5| 0| 7| 7| 4| 7| 7| 4| 7| DAY ON TEST | 5| 3| 5| 3| 7| 3| 3| 5| 3| 0| 4| 3| 2| 3| 3| 3| 4| 1| 3| 3| 5| 1| 3| 5| 3| | 6| 2| 9| 2| 8| 2| 2| 6| 2| 7| 7| 2| 8| 2| 2| 2| 4| 7| 2| 2| 7| 8| 2| 7| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| .033% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphocytic | X | Mediastinal, Fibrous Histiocytoma | | Mediastinal, Lymphoma Malignant | | Lymphocytic | X | Mediastinal, Lymphoma Malignant Mixed| X | Pancreatic, Histiocytic Sarcoma, | | Metastatic, Uterus | | Renal, Fibrous Histiocytoma | | Renal, Lymphoma Malignant Lymphocytic| X | Renal, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | I + + + + + + + + + + + + + + + + + + + M + + + +| Histiocytic Sarcoma, Metastatic, | | Uterus | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + M + + + + M + + + + + + + + + + + + + + +| Fibrous Histiocytoma | | Histiocytic Sarcoma, Metastatic, | | Uterus | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 4| 7| 6| 7| 6| 7| 7| 4| 7| 5| 6| 7| 4| 7| 7| 7| 5| 0| 7| 7| 4| 7| 7| 4| 7| DAY ON TEST | 5| 3| 5| 3| 7| 3| 3| 5| 3| 0| 4| 3| 2| 3| 3| 3| 4| 1| 3| 3| 5| 1| 3| 5| 3| | 6| 2| 9| 2| 8| 2| 2| 6| 2| 7| 7| 2| 8| 2| 2| 2| 4| 7| 2| 2| 7| 8| 2| 7| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| .033% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma, Metastatic, | | Uterus | | Lymphoma Malignant Lymphocytic | X | Osteosarcoma, Metastatic, Bone | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Renal Tubule, Carcinoma | X | __________________________________________________________________________| Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Uterus | | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X X | _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 6| 4| 6| 7| 7| 5| 7| 4| 7| 6| 7| 4| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4| DAY ON TEST | 2| 9| 5| 5| 3| 3| 2| 3| 5| 3| 2| 3| 5| 5| 5| 3| 8| 3| 2| 3| 3| 3| 3| 3| 5| | 3| 1| 7| 6| 2| 2| 1| 2| 8| 2| 8| 2| 8| 9| 8| 2| 1| 2| 3| 2| 2| 2| 2| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| .033% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + M + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + M + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple, Two| X | Histiocytic Sarcoma, Metastatic, | | Uterus | X | Lymphoma Malignant Lymphocytic | | Sarcoma Stromal, Metastatic, Uterus | | __________________________________________________________________________| Mesentery | | Fibrous Histiocytoma | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 6| 4| 6| 7| 7| 5| 7| 4| 7| 6| 7| 4| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4| DAY ON TEST | 2| 9| 5| 5| 3| 3| 2| 3| 5| 3| 2| 3| 5| 5| 5| 3| 8| 3| 2| 3| 3| 3| 3| 3| 5| | 3| 1| 7| 6| 2| 2| 1| 2| 8| 2| 8| 2| 8| 9| 8| 2| 1| 2| 3| 2| 2| 2| 2| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| .033% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Choriocarcinoma | | Histiocytic Sarcoma, Metastatic, | | Uterus | X | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma In Situ | X | Hemangioma | | Histiocytic Sarcoma | X | Leiomyosarcoma | | Lymphoma Malignant Lymphocytic | | Polyp Stromal | X | Sarcoma Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma, Metastatic, Skin | X | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Axillary, Lymphoma Malignant | | Lymphocytic | | Iliac, Lymphoma Malignant Lymphocytic| | Inguinal, Lymphoma Malignant | | Lymphocytic | | Lumbar, Lymphoma Malignant | | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 6| 4| 6| 7| 7| 5| 7| 4| 7| 6| 7| 4| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4| DAY ON TEST | 2| 9| 5| 5| 3| 3| 2| 3| 5| 3| 2| 3| 5| 5| 5| 3| 8| 3| 2| 3| 3| 3| 3| 3| 5| | 3| 1| 7| 6| 2| 2| 1| 2| 8| 2| 8| 2| 8| 9| 8| 2| 1| 2| 3| 2| 2| 2| 2| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| .033% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphocytic | | Mediastinal, Fibrous Histiocytoma | | Mediastinal, Lymphoma Malignant | | Lymphocytic | | Mediastinal, Lymphoma Malignant Mixed| X X | Pancreatic, Histiocytic Sarcoma, | | Metastatic, Uterus | X | Renal, Fibrous Histiocytoma | | Renal, Lymphoma Malignant Lymphocytic| | Renal, Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Uterus | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | | Histiocytic Sarcoma, Metastatic, | | Uterus | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Thymus | + M + + + + + + + + + + + + + + M + + + M + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 6| 4| 6| 7| 7| 5| 7| 4| 7| 6| 7| 4| 6| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 4| DAY ON TEST | 2| 9| 5| 5| 3| 3| 2| 3| 5| 3| 2| 3| 5| 5| 5| 3| 8| 3| 2| 3| 3| 3| 3| 3| 5| | 3| 1| 7| 6| 2| 2| 1| 2| 8| 2| 8| 2| 8| 9| 8| 2| 1| 2| 3| 2| 2| 2| 2| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| .033% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Histiocytic Sarcoma, Metastatic, | | Uterus | X | Lymphoma Malignant Lymphocytic | | Osteosarcoma, Metastatic, Bone | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + | Adenoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Renal Tubule, Carcinoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Uterus | X | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X X | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 6| 7| 7| 7| 7| 5| | | DAY ON TEST | 1| 0| 5| 3| 3| 3| 0| 3| 3| 4| | | | 4| 6| 8| 2| 8| 2| 1| 2| 2| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | .033% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | M + + + + + + + + + | 57 | __________________________________________________________________________|____________| Gallbladder | + A + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | I + + + + + + + + + | 58 | Carcinoma | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | M + + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Hepatocellular Carcinoma | X | 8 | Hepatocellular Adenoma | X | 8 | Hepatocellular Adenoma, Multiple, Two| X | 2 | Histiocytic Sarcoma, Metastatic, | | | Uterus | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Sarcoma Stromal, Metastatic, Uterus | | 1 | __________________________________________________________________________|____________| Mesentery | + + | 7 | Fibrous Histiocytoma | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Fibrous Histiocytoma | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Tongue | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 6| 7| 7| 7| 7| 5| | | DAY ON TEST | 1| 0| 5| 3| 3| 3| 0| 3| 3| 4| | | | 4| 6| 8| 2| 8| 2| 1| 2| 2| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | .033% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + | 60 | Capsule, Adenoma | | 2 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + | 60 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | Adenoma | | 2 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Pituitary Gland | + M + + + + M + + + | 56 | Pars Distalis, Adenoma | X X X X | 11 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 58 | Choriocarcinoma | | 1 | Histiocytic Sarcoma, Metastatic, | | | Uterus | | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 59 | Carcinoma In Situ | | 1 | Hemangioma | X | 1 | Histiocytic Sarcoma | | 1 | Leiomyosarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Polyp Stromal | | 2 | Sarcoma Stromal | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 6| 7| 7| 7| 7| 5| | | DAY ON TEST | 1| 0| 5| 3| 3| 3| 0| 3| 3| 4| | | | 4| 6| 8| 2| 8| 2| 1| 2| 2| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | .033% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Fibrosarcoma, Metastatic, Skin | | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 60 | Axillary, Lymphoma Malignant | | | Lymphocytic | | 1 | Iliac, Lymphoma Malignant Lymphocytic| | 1 | Inguinal, Lymphoma Malignant | | | Lymphocytic | | 1 | Lumbar, Lymphoma Malignant | | | Lymphocytic | | 1 | Mediastinal, Fibrous Histiocytoma | X | 1 | Mediastinal, Lymphoma Malignant | | | Lymphocytic | | 1 | Mediastinal, Lymphoma Malignant Mixed| | 3 | Pancreatic, Histiocytic Sarcoma, | | | Metastatic, Uterus | | 1 | Renal, Fibrous Histiocytoma | X | 1 | Renal, Lymphoma Malignant Lymphocytic| | 1 | Renal, Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 58 | Histiocytic Sarcoma, Metastatic, | | | Uterus | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | M M + + + + + + + + | 56 | Fibrous Histiocytoma | X | 1 | Histiocytic Sarcoma, Metastatic, | | | Uterus | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 4 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 56 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 6| 7| 7| 7| 7| 5| | | DAY ON TEST | 1| 0| 5| 3| 3| 3| 0| 3| 3| 4| | | | 4| 6| 8| 2| 8| 2| 1| 2| 2| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | .033% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 59 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Subcutaneous Tissue, Fibrosarcoma | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | Osteosarcoma | X | 1 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma | X | 5 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Histiocytic Sarcoma, Metastatic, | | | Uterus | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Osteosarcoma, Metastatic, Bone | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 4 | Adenoma | X | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | Renal Tubule, Carcinoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 59 | Histiocytic Sarcoma, Metastatic, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 6| 7| 7| 7| 7| 5| | | DAY ON TEST | 1| 0| 5| 3| 3| 3| 0| 3| 3| 4| | | | 4| 6| 8| 2| 8| 2| 1| 2| 2| 4| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | .033% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 6 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| DAY ON TEST | 3| 5| 4| 3| 3| 3| 3| 5| 3| 2| 3| 1| 3| 5| 3| 2| 3| 3| 3| 3| 5| 3| 3| 3| 5| | 1| 6| 9| 1| 1| 1| 1| 7| 1| 3| 1| 2| 1| 7| 1| 2| 1| 1| 1| 2| 7| 2| 2| 2| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| .1% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + I + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | | Hepatocellular Carcinoma | X X | Hepatocellular Carcinoma, Multiple, | | Two | | Hepatocellular Adenoma | X X X X X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Mesentery | + + + | Fibrous Histiocytoma, Metastatic, | | Liver | | Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Pharynx | | Squamous Cell Carcinoma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| DAY ON TEST | 3| 5| 4| 3| 3| 3| 3| 5| 3| 2| 3| 1| 3| 5| 3| 2| 3| 3| 3| 3| 5| 3| 3| 3| 5| | 1| 6| 9| 1| 1| 1| 1| 7| 1| 3| 1| 2| 1| 7| 1| 2| 1| 1| 1| 2| 7| 2| 2| 2| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| .1% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Carcinoma | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X | Pars Intermedia, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | X | Lymphoma Malignant Histiocytic | X | Teratoma Malignant | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Hemangiosarcoma | | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X | Polyp Stromal | X | Sarcoma Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| DAY ON TEST | 3| 5| 4| 3| 3| 3| 3| 5| 3| 2| 3| 1| 3| 5| 3| 2| 3| 3| 3| 3| 5| 3| 3| 3| 5| | 1| 6| 9| 1| 1| 1| 1| 7| 1| 3| 1| 2| 1| 7| 1| 2| 1| 1| 1| 2| 7| 2| 2| 2| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| .1% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Axillary, Lymphoma Malignant Mixed | | Iliac, Lymphoma Malignant Histiocytic| X | Iliac, Lymphoma Malignant Mixed | | Inguinal, Lymphoma Malignant Mixed | | Inguinal, Lymphoma Malignant | | Undifferentiated Cell Type | | Mediastinal, Lymphoma Malignant | | Lymphocytic | X | Mediastinal, Lymphoma Malignant Mixed| | Mediastinal, Lymphoma Malignant | | Undifferentiated Cell Type | | Pancreatic, Lymphoma Malignant | | Undifferentiated Cell Type | | Renal, Lymphoma Malignant Histiocytic| X | Renal, Lymphoma Malignant Mixed | | Renal, Lymphoma Malignant | | Undifferentiated Cell Type | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| DAY ON TEST | 3| 5| 4| 3| 3| 3| 3| 5| 3| 2| 3| 1| 3| 5| 3| 2| 3| 3| 3| 3| 5| 3| 3| 3| 5| | 1| 6| 9| 1| 1| 1| 1| 7| 1| 3| 1| 2| 1| 7| 1| 2| 1| 1| 1| 2| 7| 2| 2| 2| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| .1% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma, Metastatic, Skin | | Hemangiosarcoma | X | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma, | | Multiple, Two | X | Alveolar/Bronchiolar Carcinoma | X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Harderian Gland | + + | Adenoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X | Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 7| 4| DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 5| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 0| 3| 1| 2| 6| 0| 5| | 2| 7| 2| 6| 2| 2| 2| 7| 2| 2| 3| 2| 2| 2| 0| 2| 2| 1| 2| 1| 4| 2| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| .1% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + M + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X X X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | X | Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple, | | Two | X | Hepatocellular Adenoma | X X| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Mesentery | + + + | Fibrous Histiocytoma, Metastatic, | | Liver | X | Lymphoma Malignant Histiocytic | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Pharynx | + | Squamous Cell Carcinoma | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 7| 4| DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 5| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 0| 3| 1| 2| 6| 0| 5| | 2| 7| 2| 6| 2| 2| 2| 7| 2| 2| 3| 2| 2| 2| 0| 2| 2| 1| 2| 1| 4| 2| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| .1% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Carcinoma | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + | __________________________________________________________________________| Ovary | + + + M + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | | Lymphoma Malignant Histiocytic | | Teratoma Malignant | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Hemangiosarcoma | X | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | Polyp Stromal | | Sarcoma Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 7| 4| DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 5| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 0| 3| 1| 2| 6| 0| 5| | 2| 7| 2| 6| 2| 2| 2| 7| 2| 2| 3| 2| 2| 2| 0| 2| 2| 1| 2| 1| 4| 2| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| .1% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Axillary, Lymphoma Malignant Mixed | X | Iliac, Lymphoma Malignant Histiocytic| | Iliac, Lymphoma Malignant Mixed | X X | Inguinal, Lymphoma Malignant Mixed | X | Inguinal, Lymphoma Malignant | | Undifferentiated Cell Type | X | Mediastinal, Lymphoma Malignant | | Lymphocytic | | Mediastinal, Lymphoma Malignant Mixed| X | Mediastinal, Lymphoma Malignant | | Undifferentiated Cell Type | X | Pancreatic, Lymphoma Malignant | | Undifferentiated Cell Type | X | Renal, Lymphoma Malignant Histiocytic| | Renal, Lymphoma Malignant Mixed | X X X | Renal, Lymphoma Malignant | | Undifferentiated Cell Type | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Mixed | X X X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Thymus | + + + M + + M + + + + + + + + + + + + + + M + + +| Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + I + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Hemangiosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 5| 7| 4| DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 5| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 0| 3| 1| 2| 6| 0| 5| | 2| 7| 2| 6| 2| 2| 2| 7| 2| 2| 3| 2| 2| 2| 0| 2| 2| 1| 2| 1| 4| 2| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| .1% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma, Metastatic, Skin | X | Hemangiosarcoma | | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma, | | Multiple, Two | | Alveolar/Bronchiolar Carcinoma | | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Harderian Gland | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | | Lymphoma Malignant Histiocytic | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X X X | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 2| 3| 5| 3| 3| 5| 3| 3| 3| 3| | | | 3| 1| 8| 1| 2| 8| 2| 2| 2| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | .1% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + M + + | 59 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + | 59 | Lymphoma Malignant Mixed | | 3 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Fibrous Histiocytoma | | 1 | Hepatocellular Carcinoma | | 5 | Hepatocellular Carcinoma, Multiple, | | | Two | | 1 | Hepatocellular Adenoma | X | 8 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X | 3 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Mesentery | + | 7 | Fibrous Histiocytoma, Metastatic, | | | Liver | | 1 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Pharynx | | 1 | Squamous Cell Carcinoma | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Squamous Cell Papilloma | | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 2| 3| 5| 3| 3| 5| 3| 3| 3| 3| | | | 3| 1| 8| 1| 2| 8| 2| 2| 2| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | .1% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Tongue | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 2 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + | 60 | Capsule, Carcinoma | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + | 60 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | Adenoma | | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 57 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 60 | Pars Distalis, Adenoma | X | 4 | Pars Intermedia, Adenoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | C-Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 59 | Cystadenoma | | 1 | Lymphoma Malignant Histiocytic | | 1 | Teratoma Malignant | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 36 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 2| 3| 5| 3| 3| 5| 3| 3| 3| 3| | | | 3| 1| 8| 1| 2| 8| 2| 2| 2| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | .1% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Adenoma | | 1 | Hemangiosarcoma | | 1 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Polyp Stromal | | 1 | Sarcoma Stromal | | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Hemangiosarcoma | | 2 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 60 | Axillary, Lymphoma Malignant Mixed | | 1 | Iliac, Lymphoma Malignant Histiocytic| | 1 | Iliac, Lymphoma Malignant Mixed | | 2 | Inguinal, Lymphoma Malignant Mixed | | 1 | Inguinal, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Mediastinal, Lymphoma Malignant | | | Lymphocytic | | 1 | Mediastinal, Lymphoma Malignant Mixed| | 1 | Mediastinal, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Pancreatic, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Renal, Lymphoma Malignant Histiocytic| | 1 | Renal, Lymphoma Malignant Mixed | | 3 | Renal, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 59 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Mixed | X | 4 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 2| 3| 5| 3| 3| 5| 3| 3| 3| 3| | | | 3| 1| 8| 1| 2| 8| 2| 2| 2| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | .1% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hemangiosarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 56 | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 59 | Subcutaneous Tissue, Fibrosarcoma | X | 3 | Subcutaneous Tissue, Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + | 60 | Fibrosarcoma, Metastatic, Skin | X | 2 | Hemangiosarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma, | | | Multiple, Two | | 1 | Alveolar/Bronchiolar Carcinoma | | 1 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Harderian Gland | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 38 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 2| 3| 5| 3| 3| 5| 3| 3| 3| 3| | | | 3| 1| 8| 1| 2| 8| 2| 2| 2| 2| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | .1% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | Adenoma | | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Fibroma | | 1 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X X | 6 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 39 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 5| 7| 4| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4| DAY ON TEST | 9| 3| 5| 3| 3| 4| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| 3| 5| | 4| 0| 6| 0| 0| 4| 0| 6| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| .3% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple, | | Two | | Hepatocellular Adenoma | X X X | Hepatocellular Adenoma, Multiple, Two| X | Histiocytic Sarcoma | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Mesentery | + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M M + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X | Pars Intermedia, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 5| 7| 4| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4| DAY ON TEST | 9| 3| 5| 3| 3| 4| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| 3| 5| | 4| 0| 6| 0| 0| 4| 0| 6| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| .3% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + M + + + + + + + + +| Cystadenoma | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Iliac, Lymphoma Malignant Mixed | X | Mediastinal, Lymphoma Malignant Mixed| X | Pancreatic, Lymphoma Malignant Mixed | X | Renal, Lymphoma Malignant Lymphocytic| | Renal, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X X X | __________________________________________________________________________| Thymus | M + + + + + + M + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Liver | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Subcutaneous Tissue, Schwannoma | | Benign | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 5| 7| 4| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 4| DAY ON TEST | 9| 3| 5| 3| 3| 4| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| 3| 5| | 4| 0| 6| 0| 0| 4| 0| 6| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| 0| 0| 2| 0| 0| 0| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| .3% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Liver | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X| Hepatocellular Carcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma, Metastatic, | | Liver | | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Harderian Gland | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X X X | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 3| 7| 4| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| DAY ON TEST | 3| 0| 3| 5| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| | 0| 2| 0| 6| 0| 0| 6| 0| 0| 0| 6| 0| 0| 0| 4| 0| 7| 0| 0| 0| 0| 0| 0| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| .3% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X | Hepatocellular Carcinoma, Multiple, | | Two | | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple, Two| | Histiocytic Sarcoma | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| Pars Distalis, Adenoma | X X X| Pars Intermedia, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 3| 7| 4| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| DAY ON TEST | 3| 0| 3| 5| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| | 0| 2| 0| 6| 0| 0| 6| 0| 0| 0| 6| 0| 0| 0| 4| 0| 7| 0| 0| 0| 0| 0| 0| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| .3% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Polyp Stromal | X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + A + + + + + + + + + +| Iliac, Lymphoma Malignant Mixed | | Mediastinal, Lymphoma Malignant Mixed| | Pancreatic, Lymphoma Malignant Mixed | | Renal, Lymphoma Malignant Lymphocytic| X | Renal, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + A + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + M + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Liver | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | | Subcutaneous Tissue, Schwannoma | | Benign | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 3| 7| 4| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 7| 7| 4| 7| DAY ON TEST | 3| 0| 3| 5| 3| 3| 5| 3| 3| 3| 5| 3| 3| 3| 7| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| | 0| 2| 0| 6| 0| 0| 6| 0| 0| 0| 6| 0| 0| 0| 4| 0| 7| 0| 0| 0| 0| 0| 0| 7| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| .3% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma, Metastatic, | | Liver | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma, Metastatic, | | Liver | X | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Harderian Gland | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X | _____________________________________________________________________________________________________________________| Page 45 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| | | | 0| 0| 0| 0| 0| 7| 0| 0| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | .3% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + M + | 58 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 59 | Lymphoma Malignant Mixed | | 4 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Hepatocellular Carcinoma | X | 6 | Hepatocellular Carcinoma, Multiple, | | | Two | X | 1 | Hepatocellular Adenoma | | 7 | Hepatocellular Adenoma, Multiple, Two| | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Mesentery | | 3 | __________________________________________________________________________|____________| Pancreas | + + + + M + + + + + | 59 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Tongue | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 5 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + M + + + + + | 59 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 46 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| | | | 0| 0| 0| 0| 0| 7| 0| 0| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | .3% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + + + | 55 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 59 | Pars Distalis, Adenoma | X | 5 | Pars Intermedia, Adenoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 59 | Cystadenoma | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 60 | Polyp Stromal | X | 6 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Hemangiosarcoma | | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 59 | Iliac, Lymphoma Malignant Mixed | X | 2 | Mediastinal, Lymphoma Malignant Mixed| X | 2 | Pancreatic, Lymphoma Malignant Mixed | | 1 | Renal, Lymphoma Malignant Lymphocytic| | 1 | Renal, Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 59 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + I + + + | 58 | Lymphoma Malignant Mixed | X | 4 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 59 | Lymphoma Malignant Mixed | X | 4 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 57 | Histiocytic Sarcoma, Metastatic, | | | Liver | | 1 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 47 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| | | | 0| 0| 0| 0| 0| 7| 0| 0| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | .3% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Basal Cell Adenoma | | 1 | Subcutaneous Tissue, Schwannoma | | | Benign | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + | 60 | Fibrosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Histiocytic Sarcoma, Metastatic, | | | Liver | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma | | 5 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | Histiocytic Sarcoma, Metastatic, | | | Liver | | 1 | Lymphoma Malignant Lymphocytic | | 2 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | __________________________________________________________________________|____________| Harderian Gland | + | 1 | Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 48 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| | | | 0| 0| 0| 0| 0| 7| 0| 0| 0| 0| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | .3% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | X | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 49 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| DAY ON TEST | 2| 2| 5| 2| 2| 2| 2| 2| 2| 7| 5| 2| 2| 2| 5| 2| 2| 2| 4| 2| 2| 1| 2| 5| 0| | 9| 9| 6| 9| 9| 9| 9| 9| 9| 0| 6| 9| 9| 9| 6| 9| 9| 4| 4| 9| 5| 0| 9| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + M + + + + + + + + + + M + M +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + A + A M + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + M + + + + + + + A + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Hemangiosarcoma | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | | Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple, | | Two | X | Hepatocellular Carcinoma, Multiple, | | Three | X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple, Two| | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Mesentery | | Cholangiocarcinoma, Metastatic, Liver| | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Pharynx | + | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| DAY ON TEST | 2| 2| 5| 2| 2| 2| 2| 2| 2| 7| 5| 2| 2| 2| 5| 2| 2| 2| 4| 2| 2| 1| 2| 5| 0| | 9| 9| 6| 9| 9| 9| 9| 9| 9| 0| 6| 9| 9| 9| 6| 9| 9| 4| 4| 9| 5| 0| 9| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Lymphoma Malignant Lymphocytic | X | Capsule, Adenoma | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + M + + + + + + M + + + + + + M + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Iliac, Lymphoma Malignant Lymphocytic| X | Inguinal, Lymphoma Malignant | | Lymphocytic | X | Mediastinal, Lymphoma Malignant | | Lymphocytic | X | Mediastinal, Lymphoma Malignant Mixed| | Pancreatic, Lymphoma Malignant | | Lymphocytic | X | Renal, Lymphoma Malignant Lymphocytic| X | Renal, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + M M + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + M + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| DAY ON TEST | 2| 2| 5| 2| 2| 2| 2| 2| 2| 7| 5| 2| 2| 2| 5| 2| 2| 2| 4| 2| 2| 1| 2| 5| 0| | 9| 9| 6| 9| 9| 9| 9| 9| 9| 0| 6| 9| 9| 9| 6| 9| 9| 4| 4| 9| 5| 0| 9| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Thymus | + + + M + + + + + + + + + + + + + + M M M + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Oligodendroglioma Malignant | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X | Alveolar/Bronchiolar Carcinoma | X X X | Cholangiocarcinoma, Metastatic, Liver| | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| DAY ON TEST | 2| 2| 5| 2| 2| 2| 2| 2| 2| 7| 5| 2| 2| 2| 5| 2| 2| 2| 4| 2| 2| 1| 2| 5| 0| | 9| 9| 6| 9| 9| 9| 9| 9| 9| 0| 6| 9| 9| 9| 6| 9| 9| 4| 4| 9| 5| 0| 9| 7| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS - cont | | | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 4| 6| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4| DAY ON TEST | 2| 2| 5| 1| 7| 2| 5| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5| 2| 2| 0| 2| 2| 2| 2| 5| | 9| 7| 7| 8| 7| 9| 8| 9| 9| 9| 9| 8| 9| 9| 9| 9| 8| 9| 9| 8| 9| 9| 9| 9| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Hemangiosarcoma | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | | Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple, | | Two | | Hepatocellular Carcinoma, Multiple, | | Three | X | Hepatocellular Adenoma | X X X| Hepatocellular Adenoma, Multiple, Two| | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Mesentery | + + | Cholangiocarcinoma, Metastatic, Liver| | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Pharynx | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 54 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 4| 6| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4| DAY ON TEST | 2| 2| 5| 1| 7| 2| 5| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5| 2| 2| 0| 2| 2| 2| 2| 5| | 9| 7| 7| 8| 7| 9| 8| 9| 9| 9| 9| 8| 9| 9| 9| 9| 8| 9| 9| 8| 9| 9| 9| 9| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Lymphoma Malignant Lymphocytic | | Capsule, Adenoma | X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Malignant | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + + + + M + I M + + + M + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + M + + + M + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Iliac, Lymphoma Malignant Lymphocytic| | Inguinal, Lymphoma Malignant | | Lymphocytic | | Mediastinal, Lymphoma Malignant | | Lymphocytic | | Mediastinal, Lymphoma Malignant Mixed| X | Pancreatic, Lymphoma Malignant | | Lymphocytic | | Renal, Lymphoma Malignant Lymphocytic| | Renal, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| Page 55 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 4| 6| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4| DAY ON TEST | 2| 2| 5| 1| 7| 2| 5| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5| 2| 2| 0| 2| 2| 2| 2| 5| | 9| 7| 7| 8| 7| 9| 8| 9| 9| 9| 9| 8| 9| 9| 9| 9| 8| 9| 9| 8| 9| 9| 9| 9| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Thymus | + M + + I + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Oligodendroglioma Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X| Alveolar/Bronchiolar Carcinoma | X | Cholangiocarcinoma, Metastatic, Liver| | Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + | Adenoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 56 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 4| 6| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4| DAY ON TEST | 2| 2| 5| 1| 7| 2| 5| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5| 2| 2| 0| 2| 2| 2| 2| 5| | 9| 7| 7| 8| 7| 9| 8| 9| 9| 9| 9| 8| 9| 9| 9| 9| 8| 9| 9| 8| 9| 9| 9| 9| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS - cont | | | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| | | DAY ON TEST | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| | | | 9| 9| 9| 9| 8| 8| 9| 9| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 57 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 57 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | M + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | Carcinoma | X X | 3 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Cholangiocarcinoma | X | 1 | Hepatocellular Carcinoma | X X | 8 | Hepatocellular Carcinoma, Multiple, | | | Two | | 1 | Hepatocellular Carcinoma, Multiple, | | | Three | X | 3 | Hepatocellular Adenoma | X X X | 10 | Hepatocellular Adenoma, Multiple, Two| X | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Mesentery | + | 3 | Cholangiocarcinoma, Metastatic, Liver| X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Pharynx | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Squamous Cell Papilloma | X | 3 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Tongue | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Tooth | + + | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 58 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| | | DAY ON TEST | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| | | | 9| 9| 9| 9| 8| 8| 9| 9| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + | 60 | Adenoma | | 2 | Lymphoma Malignant Lymphocytic | | 1 | Capsule, Adenoma | | 3 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + | 60 | Pheochromocytoma Malignant | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 52 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 58 | Pars Distalis, Adenoma | | 3 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | Follicular Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + | 38 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 60 | Iliac, Lymphoma Malignant Lymphocytic| | 1 | Inguinal, Lymphoma Malignant | | | Lymphocytic | | 1 | Mediastinal, Lymphoma Malignant | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 59 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| | | DAY ON TEST | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| | | | 9| 9| 9| 9| 8| 8| 9| 9| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphocytic | | 1 | Mediastinal, Lymphoma Malignant Mixed| | 1 | Pancreatic, Lymphoma Malignant | | | Lymphocytic | | 1 | Renal, Lymphoma Malignant Lymphocytic| | 1 | Renal, Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 58 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 58 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Thymus | M + M + + + + + + + | 52 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Subcutaneous Tissue, Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | Oligodendroglioma Malignant | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma | X | 10 | Alveolar/Bronchiolar Carcinoma | X | 5 | Cholangiocarcinoma, Metastatic, Liver| X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 60 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 5| 7| 7| 7| 7| | | DAY ON TEST | 2| 2| 2| 2| 5| 0| 2| 2| 2| 2| | | | 9| 9| 9| 9| 8| 8| 9| 9| 9| 9| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 4 | Adenoma | X | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 61 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| DAY ON TEST | 5| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| | 6| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 7| 4| 3| 3| 3| 3| 3| 2| 7| 2| 3| 3| 7| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| .033% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | M + + + + + M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | M + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple, | | Two | X X X | Hepatocellular Adenoma | X X X X X X | Hepatocellular Adenoma, Multiple, Two| | Hepatocellular Adenoma, Multiple, | | Three | X | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Capsule, Adenoma | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X| _____________________________________________________________________________________________________________________| Page 62 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| DAY ON TEST | 5| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| | 6| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 7| 4| 3| 3| 3| 3| 3| 2| 7| 2| 3| 3| 7| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| .033% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | + | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Pancreatic, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | M + + I + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Thymus | + + + + + + + M + + + + + M + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M + M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 63 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 5| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| DAY ON TEST | 5| 3| 3| 3| 6| 3| 5| 3| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 5| 3| | 6| 2| 2| 2| 2| 2| 6| 3| 3| 3| 3| 7| 4| 3| 3| 3| 3| 3| 2| 7| 2| 3| 3| 7| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| .033% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X| Alveolar/Bronchiolar Adenoma, | | Multiple, Two | X | Alveolar/Bronchiolar Carcinoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 64 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 3| 6| 3| 3| 3| 3| 3| 5| 3| 3| 2| 5| 3| 3| 3| 3| 5| 3| | 3| 3| 3| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 2| 8| 3| 3| 3| 3| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| .033% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | M + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hepatocellular Carcinoma | X X X X X X X | Hepatocellular Carcinoma, Multiple, | | Two | | Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple, Two| X | Hepatocellular Adenoma, Multiple, | | Three | | __________________________________________________________________________| Mesentery | + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Capsule, Adenoma | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | _____________________________________________________________________________________________________________________| Page 65 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 3| 6| 3| 3| 3| 3| 3| 5| 3| 3| 2| 5| 3| 3| 3| 3| 5| 3| | 3| 3| 3| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 2| 8| 3| 3| 3| 3| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| .033% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Pancreatic, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Thymus | + I + + + + + + + + + + + + + + + + + + + + + + M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| Page 66 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 5| 3| 6| 3| 3| 3| 3| 3| 5| 3| 3| 2| 5| 3| 3| 3| 3| 5| 3| | 3| 3| 3| 3| 3| 3| 8| 3| 1| 3| 3| 3| 3| 3| 8| 3| 3| 2| 8| 3| 3| 3| 3| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| .033% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X X| Alveolar/Bronchiolar Adenoma, | | Multiple, Two | | Alveolar/Bronchiolar Carcinoma | X X | Hepatocellular Carcinoma, Metastatic,| | Liver | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + + | Adenoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X X | _____________________________________________________________________________________________________________________| Page 67 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| | | DAY ON TEST | 3| 5| 8| 3| 3| 0| 0| 3| 3| 3| | | | 3| 8| 9| 3| 3| 8| 5| 3| 3| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | .033% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 57 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + A + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + A + + + + + + + | 59 | Carcinoma | | 1 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Hemangiosarcoma | X | 2 | Hepatocellular Carcinoma | | 10 | Hepatocellular Carcinoma, Multiple, | | | Two | X | 4 | Hepatocellular Adenoma | X | 12 | Hepatocellular Adenoma, Multiple, Two| | 1 | Hepatocellular Adenoma, Multiple, | | | Three | | 1 | __________________________________________________________________________|____________| Mesentery | | 3 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Squamous Cell Papilloma | X X | 4 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Tongue | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Tooth | | 4 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + | 60 | Adenoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 68 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| | | DAY ON TEST | 3| 5| 8| 3| 3| 0| 0| 3| 3| 3| | | | 3| 8| 9| 3| 3| 8| 5| 3| 3| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | .033% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Capsule, Adenoma | X | 2 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + | 60 | Pheochromocytoma Benign | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | Adenoma | X | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + M | 58 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | | 1 | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 60 | Hemangioma | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + | 42 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Hemangiosarcoma | X | 2 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 60 | Pancreatic, Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 56 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 59 | Lymphoma Malignant Mixed | X | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Hemangiosarcoma | X | 2 | Lymphoma Malignant Mixed | X | 2 | __________________________________________________________________________|____________| Thymus | + + M + + + + + + + | 55 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Subcutaneous Tissue, Hemangiosarcoma | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 69 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| | | DAY ON TEST | 3| 5| 8| 3| 3| 0| 0| 3| 3| 3| | | | 3| 8| 9| 3| 3| 8| 5| 3| 3| 3| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | .033% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | Hemangiosarcoma | X | 2 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + | 60 | Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma | X X X X | 14 | Alveolar/Bronchiolar Adenoma, | | | Multiple, Two | | 1 | Alveolar/Bronchiolar Carcinoma | | 3 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | | 2 | Adenoma | | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Lymphoma Malignant Mixed | X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 70 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 6| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| 2| 2| 3| 5| 3| 3| 7| 3| 3| 2| 0| 5| 3| 3| 3| | 1| 1| 6| 1| 1| 1| 1| 1| 6| 1| 0| 0| 1| 7| 1| 1| 1| 1| 1| 6| 8| 7| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| .1% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + M + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X | Hepatocellular Carcinoma, Multiple, | | Two | | Hepatocellular Carcinoma, Multiple, | | Five | | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple, Two| X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Lymphoma Malignant Mixed | | Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 71 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 6| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| 2| 2| 3| 5| 3| 3| 7| 3| 3| 2| 0| 5| 3| 3| 3| | 1| 1| 6| 1| 1| 1| 1| 1| 6| 1| 0| 0| 1| 7| 1| 1| 1| 1| 1| 6| 8| 7| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| .1% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Adenoma | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + M + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + M + M + + + + +| __________________________________________________________________________| Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Carcinoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Axillary, Lymphoma Malignant Mixed | | Iliac, Lymphoma Malignant Mixed | | Mediastinal, Lymphoma Malignant Mixed| | Renal, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + M + M + + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| _____________________________________________________________________________________________________________________| Page 72 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 6| 6| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| 2| 2| 3| 5| 3| 3| 7| 3| 3| 2| 0| 5| 3| 3| 3| | 1| 1| 6| 1| 1| 1| 1| 1| 6| 1| 0| 0| 1| 7| 1| 1| 1| 1| 1| 6| 8| 7| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| .1% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrous | | Histiocytoma | | Subcutaneous Tissue, Hemangiosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X | Alveolar/Bronchiolar Carcinoma | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + + +| Adenoma | X X X| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| Page 73 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| DAY ON TEST | 3| 5| 2| 3| 1| 3| 5| 3| 1| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| | 1| 7| 4| 1| 8| 1| 7| 1| 8| 7| 1| 1| 1| 8| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| .1% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hepatocellular Carcinoma | X X| Hepatocellular Carcinoma, Multiple, | | Two | X | Hepatocellular Carcinoma, Multiple, | | Five | X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple, Two| X X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Mesentery | + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | | Lymphoma Malignant Mixed | X | Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 74 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| DAY ON TEST | 3| 5| 2| 3| 1| 3| 5| 3| 1| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| | 1| 7| 4| 1| 8| 1| 7| 1| 8| 7| 1| 1| 1| 8| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| .1% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Adenoma | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Carcinoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Axillary, Lymphoma Malignant Mixed | X | Iliac, Lymphoma Malignant Mixed | X | Mediastinal, Lymphoma Malignant Mixed| X | Renal, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| _____________________________________________________________________________________________________________________| Page 75 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 4| 7| 7| 6| 7| 4| 7| 6| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| DAY ON TEST | 3| 5| 2| 3| 1| 3| 5| 3| 1| 5| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| | 1| 7| 4| 1| 8| 1| 7| 1| 8| 7| 1| 1| 1| 8| 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| .1% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrous | | Histiocytoma | X | Subcutaneous Tissue, Hemangiosarcoma | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + + | Adenoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| Page 76 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| | | | 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | .1% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + M + + + + | 59 | __________________________________________________________________________|____________| Gallbladder | + + + + + + M + + + | 58 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 60 | Carcinoma | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | X X X X X | 9 | Hepatocellular Carcinoma, Multiple, | | | Two | | 1 | Hepatocellular Carcinoma, Multiple, | | | Five | | 1 | Hepatocellular Adenoma | X X | 7 | Hepatocellular Adenoma, Multiple, Two| | 3 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Mesentery | | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Basal Cell Adenoma | | 1 | Lymphoma Malignant Mixed | | 1 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Tongue | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 2 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 77 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| | | | 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | .1% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + | 60 | Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 59 | Adenoma | X X | 3 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + + + + | 55 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + M + + | 58 | Pars Distalis, Carcinoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | Follicular Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 60 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + | 35 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 60 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 60 | Interstitial Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 60 | Axillary, Lymphoma Malignant Mixed | | 1 | Iliac, Lymphoma Malignant Mixed | | 1 | Mediastinal, Lymphoma Malignant Mixed| | 1 | Renal, Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 60 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 78 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| | | | 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | .1% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 60 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Hemangiosarcoma | | 2 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 57 | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Subcutaneous Tissue, Fibrous | | | Histiocytoma | | 1 | Subcutaneous Tissue, Hemangiosarcoma | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | Osteosarcoma | | 1 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + | 60 | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Carcinoma, Metastatic, Pituitary | | | Gland | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma | | 8 | Alveolar/Bronchiolar Carcinoma | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Eye | + | 3 | __________________________________________________________________________|____________| Harderian Gland | + | 6 | Adenoma | X | 6 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 79 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| | | DAY ON TEST | 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| | | | 1| 1| 1| 1| 1| 8| 1| 1| 1| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | .1% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 80 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 4| 7| DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 2| 8| 5| 3| 3| 3| 3| 5| 5| 3| 5| 3| 3| 5| 3| | 0| 0| 0| 0| 0| 4| 0| 6| 0| 0| 5| 3| 6| 0| 0| 0| 0| 2| 6| 1| 6| 1| 1| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| .3% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hepatocellular Carcinoma | X | Hepatocellular Carcinoma, Multiple, | | Two | X | Hepatocellular Adenoma | X| Lymphoma Malignant Lymphocytic | X | Mesothelioma Malignant, Metastatic, | | Mesentery | X | __________________________________________________________________________| Mesentery | + | Mesothelioma Malignant | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | X | Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 81 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 4| 7| DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 2| 8| 5| 3| 3| 3| 3| 5| 5| 3| 5| 3| 3| 5| 3| | 0| 0| 0| 0| 0| 4| 0| 6| 0| 0| 5| 3| 6| 0| 0| 0| 0| 2| 6| 1| 6| 1| 1| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| .3% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma, Metastatic, Bone | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Thymus | + + + + + + + + M + M + I + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 82 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 5| 7| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 4| 7| DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 5| 3| 3| 2| 8| 5| 3| 3| 3| 3| 5| 5| 3| 5| 3| 3| 5| 3| | 0| 0| 0| 0| 0| 4| 0| 6| 0| 0| 5| 3| 6| 0| 0| 0| 0| 2| 6| 1| 6| 1| 1| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| .3% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Osteosarcoma | X | __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X| Alveolar/Bronchiolar Carcinoma | X X| Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Lymphocytic | X | Mesothelioma Malignant, Metastatic, | | Mesentery | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + + + + | Adenoma | X X X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 83 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 7| 6| 7| 4| 7| 4| DAY ON TEST | 3| 3| 3| 4| 3| 5| 2| 3| 3| 3| 0| 3| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 5| 3| 7| | 1| 1| 1| 7| 1| 6| 4| 0| 0| 0| 0| 0| 0| 1| 1| 6| 1| 1| 7| 1| 1| 1| 7| 0| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| .3% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + M + + + + + + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple, | | Two | | Hepatocellular Adenoma | X | Lymphoma Malignant Lymphocytic | | Mesothelioma Malignant, Metastatic, | | Mesentery | | __________________________________________________________________________| Mesentery | | Mesothelioma Malignant | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | Squamous Cell Papilloma | X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 84 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 7| 6| 7| 4| 7| 4| DAY ON TEST | 3| 3| 3| 4| 3| 5| 2| 3| 3| 3| 0| 3| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 5| 3| 7| | 1| 1| 1| 7| 1| 6| 4| 0| 0| 0| 0| 0| 0| 1| 1| 6| 1| 1| 7| 1| 1| 1| 7| 0| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| .3% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| Pars Distalis, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma, Metastatic, Bone | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 85 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 4| 7| 6| 7| 4| 7| 4| DAY ON TEST | 3| 3| 3| 4| 3| 5| 2| 3| 3| 3| 0| 3| 3| 3| 3| 5| 3| 3| 5| 3| 5| 3| 5| 3| 7| | 1| 1| 1| 7| 1| 6| 4| 0| 0| 0| 0| 0| 0| 1| 1| 6| 1| 1| 7| 1| 1| 1| 7| 0| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| .3% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Osteosarcoma | | __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Lymphocytic | | Mesothelioma Malignant, Metastatic, | | Mesentery | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 86 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| | | DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 8| 0| | | | 0| 0| 7| 0| 0| 0| 0| 0| 4| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | .3% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 58 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Hemangiosarcoma | X | 1 | Hepatocellular Carcinoma | | 5 | Hepatocellular Carcinoma, Multiple, | | | Two | X X | 3 | Hepatocellular Adenoma | | 2 | Lymphoma Malignant Lymphocytic | | 1 | Mesothelioma Malignant, Metastatic, | | | Mesentery | | 1 | __________________________________________________________________________|____________| Mesentery | | 1 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Squamous Cell Carcinoma | | 1 | Squamous Cell Papilloma | | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Tongue | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Tooth | + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Hepatocellular Carcinoma, Metastatic,| | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 87 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| | | DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 8| 0| | | | 0| 0| 7| 0| 0| 0| 0| 0| 4| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | .3% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Liver | | 1 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + | 60 | Capsule, Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 59 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + M + | 57 | Pars Distalis, Adenoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | Follicular Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + | 25 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Hemangiosarcoma | X X | 2 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + M | 59 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 60 | Osteosarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 88 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| | | DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 8| 0| | | | 0| 0| 7| 0| 0| 0| 0| 0| 4| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | .3% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Hemangiosarcoma | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Thymus | + M + + + + M + + + | 54 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | Hemangiosarcoma | X | 1 | Osteosarcoma | | 1 | __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + | 60 | Hemangiosarcoma | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma | X X X | 6 | Alveolar/Bronchiolar Carcinoma | | 3 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 2 | Lymphoma Malignant Lymphocytic | | 1 | Mesothelioma Malignant, Metastatic, | | | Mesentery | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Harderian Gland | | 5 | Adenoma | | 5 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 89 NTP Experiment-Test: 05120-04 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC BENZYL ACETATE Date: 04/02/97 Route: DOSED FEED Time: 11:21:08 __________________________________________________________________________________________________________________________________ | 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| | | DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 8| 0| | | | 0| 0| 7| 0| 0| 0| 0| 0| 4| 1| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | .3% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Lymphoma Malignant Lymphocytic | | 1 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 90 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------