TDMS Study 05120-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst BENZYL ACETATE DATE: 09/16/94
EXPERIMENT: 05120 TEST: 04 TIME: 03:57:58
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55082 ROUTE: DOSED FEED NTP C#: 06508B
PATHOLOGIST: JAMES HEATH SCOT EUSTIS CAS: 140-11-4
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst BENZYL ACETATE DATE: 09/16/94
EXPERIMENT: 05120 TEST: 04 TIME: 03:57:58
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55082 ROUTE: DOSED FEED NTP C#: 06508B
PATHOLOGIST: JAMES HEATH SCOT EUSTIS CAS: 140-11-4
MICE(B6C3F1)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Gallbladder
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Southern Research Inst BENZYL ACETATE DATE: 09/16/94
EXPERIMENT: 05120 TEST: 04 TIME: 03:57:58
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55082 ROUTE: DOSED FEED NTP C#: 06508B
PATHOLOGIST: JAMES HEATH SCOT EUSTIS CAS: 140-11-4
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF BENZYL ACETATE
====================================================================================================
MALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Liver Hepatocellular Adenoma
Hepatocellular Carcinoma or Hepatocellular Adenoma
Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
Lung Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
All Organs Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE MICE
-------------
ORGAN MORPHOLOGY
------- ------------
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Uterus Polyp Stromal
Sarcoma Stromal or Polyp Stromal
All Organs Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/16/94 EXPERIMENT: 05120 TEST: 04 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0% .033% .1% .3% | 0% .033% .1% .3% |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 3/60 (5%) 1/60 (2%) 1/60 (2%) | 0/60 (0%) 2/60 (3%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 11.9% 7.0% 2.4% 2.6% | 0.0% 6.7% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/39 (10%) 3/43 (7%) 1/41 (2%) 1/39 (3%) | 0/29 (0%) 0/28 (0%) 0/37 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 457 (I) 729 (T) 729 (T) 729 (T) | --- 723 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.095N P=0.312N P=0.096N P=0.105N | P=0.305N P=0.238 (e) (e) |
|INCIDENTAL TUMOR | P=0.095N P=0.312N P=0.096N P=0.105N | P=0.897N P=0.348 (e) (e) |
|LOGISTIC REGRESSION | P=0.091N P=0.349N P=0.102N P=0.104N | P=0.333N P=0.247 (e) (e) |
|COCHRAN-ARMITAGE | P=0.090N | P=0.379N |
|FISHER EXACT | P=0.359N P=0.103N P=0.103N | P=0.248 (e) (e) |
|=================================================================================================================================|
| |
|Bone |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 0/60 (0%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 4.2% 0.0% 2.4% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/39 (0%) 0/43 (0%) 0/41 (0%) 0/39 (0%) | 0/29 (0%) 0/28 (0%) 0/37 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | --- 562 --- 701 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.610 P=0.244 (e) P=0.495 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.645 P=0.288 (e) P=0.536 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.673 P=0.224 (e) P=0.500 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.615 | (e) |
|FISHER EXACT | P=0.248 (e) P=0.500 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/16/94 EXPERIMENT: 05120 TEST: 04 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0% .033% .1% .3% | 0% .033% .1% .3% |
| | | |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 1/60 (2%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 2/60 (3%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 4.2% 2.0% 4.5% | 0.0% 0.0% 5.4% 2.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/39 (0%) 0/43 (0%) 0/41 (0%) 0/39 (0%) | 0/29 (0%) 0/28 (0%) 2/37 (5%) 1/44 (2%) |
|FIRST INCIDENCE (DAYS) | --- 562 618 584 | --- --- 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.310 P=0.244 P=0.513 P=0.240 | P=0.476 (e) P=0.293 P=0.583 |
|INCIDENTAL TUMOR | P=0.292 P=0.288 P=0.602 P=0.260 | P=0.476 (e) P=0.293 P=0.583 |
|LOGISTIC REGRESSION | P=0.370 P=0.224 P=0.491 P=0.237 | P=0.476 (e) P=0.293 P=0.583 |
|COCHRAN-ARMITAGE | P=0.314 | P=0.354 |
|FISHER EXACT | P=0.248 P=0.500 P=0.248 | (e) P=0.248 P=0.500 |
|=================================================================================================================================|
| |
|Harderian Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 2/60 (3%) 6/60 (10%) 5/60 (8%) | 3/60 (5%) 4/60 (7%) 2/60 (3%) 1/60 (2%) |
|ADJUSTED (b) | 9.9% 4.7% 13.8% 11.9% | 8.3% 13.3% 5.2% 2.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/39 (8%) 2/43 (5%) 4/41 (10%) 2/39 (5%) | 1/29 (3%) 2/28 (7%) 1/37 (3%) 1/44 (2%) |
|FIRST INCIDENCE (DAYS) | 724 729 (T) 708 683 | 600 723 723 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.288 P=0.298N P=0.400 P=0.495 | P=0.085N P=0.501 P=0.400N P=0.220N |
|INCIDENTAL TUMOR | P=0.415 P=0.365N P=0.347 P=0.553 | P=0.259N P=0.542 P=0.537N P=0.467N |
|LOGISTIC REGRESSION | P=0.292 P=0.314N P=0.391 P=0.493 | P=0.129N P=0.514 P=0.463N P=0.287N |
|COCHRAN-ARMITAGE | P=0.313 | P=0.165N |
|FISHER EXACT | P=0.340N P=0.372 P=0.500 | P=0.500 P=0.500N P=0.309N |
|=================================================================================================================================|
DATE: 09/16/94 EXPERIMENT: 05120 TEST: 04 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0% .033% .1% .3% | 0% .033% .1% .3% |
| | | |
|=================================================================================================================================|
| |
|Intestine Small |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 1/60 (2%) 1/60 (2%) 0/60 (0%) | 1/60 (2%) 1/60 (2%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 6.9% 2.3% 2.4% 0.0% | 2.7% 2.3% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/39 (5%) 1/43 (2%) 1/41 (2%) 0/39 (0%) | 0/29 (0%) 0/28 (0%) 0/37 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 458 (I) 729 (T) 729 (T) --- | 656 628 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.120N P=0.281N P=0.294N P=0.123N | P=0.286N P=0.738N P=0.452N P=0.465N |
|INCIDENTAL TUMOR | P=0.120N P=0.281N P=0.294N P=0.123N | P=0.476N P=0.735 P=0.436N (e) |
|LOGISTIC REGRESSION | P=0.116N P=0.307N P=0.308N P=0.122N | P=0.308N P=0.762 P=0.500N P=0.499N |
|COCHRAN-ARMITAGE | P=0.116N | P=0.305N |
|FISHER EXACT | P=0.309N P=0.309N P=0.122N | P=0.752N P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Intestine Small: Jejunum |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 1/60 (2%) 1/60 (2%) 0/60 (0%) | 1/60 (2%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 6.9% 2.3% 2.4% 0.0% | 2.7% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/39 (5%) 1/43 (2%) 1/41 (2%) 0/39 (0%) | 0/29 (0%) 0/28 (0%) 0/37 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 458 (I) 729 (T) 729 (T) --- | 656 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.120N P=0.281N P=0.294N P=0.123N | P=0.451N P=0.484N P=0.452N P=0.465N |
|INCIDENTAL TUMOR | P=0.120N P=0.281N P=0.294N P=0.123N | P=0.904N P=0.403N P=0.436N (e) |
|LOGISTIC REGRESSION | P=0.116N P=0.307N P=0.308N P=0.122N | P=0.471N P=0.500N P=0.500N P=0.499N |
|COCHRAN-ARMITAGE | P=0.116N | P=0.472N |
|FISHER EXACT | P=0.309N P=0.309N P=0.122N | P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/16/94 EXPERIMENT: 05120 TEST: 04 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0% .033% .1% .3% | 0% .033% .1% .3% |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 3/59 (5%) 0/60 (0%) | 3/60 (5%) 2/60 (3%) 2/60 (3%) 0/59 (0%) |
|ADJUSTED (b) | 0.0% 4.7% 7.2% 0.0% | 8.8% 7.1% 4.8% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/39 (0%) 2/43 (5%) 2/40 (5%) 0/39 (0%) | 2/29 (7%) 2/28 (7%) 1/37 (3%) 0/43 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) 711 --- | 533 729 (T) 702 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.399N P=0.260 P=0.129 (e) | P=0.054N P=0.517N P=0.398N P=0.079N |
|INCIDENTAL TUMOR | P=0.362N P=0.260 P=0.113 (e) | P=0.101N P=0.529N P=0.596N P=0.139N |
|LOGISTIC REGRESSION | P=0.395N P=0.260 P=0.123 (e) | P=0.085N P=0.492N P=0.467N P=0.120N |
|COCHRAN-ARMITAGE | P=0.385N | P=0.101N |
|FISHER EXACT | P=0.248 P=0.119 (e) | P=0.500N P=0.500N P=0.125N |
|=================================================================================================================================|
| |
|Liver |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 1/60 (2%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 4.2% 2.1% 2.1% | 0.0% 0.0% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/39 (0%) 0/43 (0%) 0/41 (0%) 0/39 (0%) | 0/29 (0%) 0/28 (0%) 0/37 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | --- 562 620 584 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.613 P=0.244 P=0.509 P=0.504 | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.590 P=0.288 P=0.602 P=0.500 | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.614 P=0.224 P=0.492 P=0.496 | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.614 | (e) |
|FISHER EXACT | P=0.248 P=0.500 P=0.500 | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/16/94 EXPERIMENT: 05120 TEST: 04 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0% .033% .1% .3% | 0% .033% .1% .3% |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 11/60 (18%) 14/60 (23%) 10/60 (17%) 2/60 (3%) | 7/60 (12%) 10/60 (17%) 8/60 (13%) 8/60 (13%) |
|ADJUSTED (b) | 26.3% 31.5% 21.8% 4.2% | 20.8% 28.5% 19.8% 17.3% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 1/10 (10%) 2/10 (20%) 1/10 (10%) | 1/10 (10%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 9/39 (23%) 13/43 (30%) 7/41 (17%) 1/39 (3%) | 5/29 (17%) 6/28 (21%) 6/37 (16%) 6/44 (14%) |
|FIRST INCIDENCE (DAYS) | 458 (I) 458 (I) 457 (I) 456 (I) | 456 (I) 507 458 (I) 544 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.003N** P=0.418 P=0.460N P=0.010N** | P=0.235N P=0.297 P=0.545N P=0.455N |
|INCIDENTAL TUMOR | P=0.002N** P=0.378 P=0.483N P=0.009N** | P=0.528N P=0.331 P=0.539N P=0.532 |
|LOGISTIC REGRESSION | P=0.002N** P=0.345 P=0.483N P=0.009N** | P=0.486N P=0.304 P=0.566 P=0.553 |
|COCHRAN-ARMITAGE | P=0.002N** | P=0.537N |
|FISHER EXACT | P=0.327 P=0.500N P=0.008N** | P=0.301 P=0.500 P=0.500 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/60 (20%) 14/60 (23%) 11/60 (18%) 8/60 (13%) | 10/60 (17%) 8/60 (13%) 6/60 (10%) 7/60 (12%) |
|ADJUSTED (b) | 26.6% 29.6% 24.7% 18.5% | 27.0% 20.9% 14.1% 15.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 7/39 (18%) 10/43 (23%) 8/41 (20%) 5/39 (13%) | 4/29 (14%) 3/28 (11%) 3/37 (8%) 7/44 (16%) |
|FIRST INCIDENCE (DAYS) | 508 508 618 584 | 520 507 568 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.155N P=0.497 P=0.454N P=0.241N | P=0.121N P=0.387N P=0.106N P=0.107N |
|INCIDENTAL TUMOR | P=0.098N P=0.275 P=0.577 P=0.236N | P=0.493N P=0.470N P=0.338N P=0.500N |
|LOGISTIC REGRESSION | P=0.088N P=0.413 P=0.434N P=0.154N | P=0.505N P=0.463N P=0.371N P=0.220N |
|COCHRAN-ARMITAGE | P=0.125N | P=0.315N |
|FISHER EXACT | P=0.412 P=0.500N P=0.232N | P=0.399N P=0.211N P=0.301N |
|=================================================================================================================================|
DATE: 09/16/94 EXPERIMENT: 05120 TEST: 04 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0% .033% .1% .3% | 0% .033% .1% .3% |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 23/60 (38%) 23/60 (38%) 20/60 (33%) 10/60 (17%) | 15/60 (25%) 15/60 (25%) 14/60 (23%) 14/60 (23%) |
|ADJUSTED (b) | 49.5% 47.6% 41.9% 22.2% | 38.5% 39.6% 32.3% 30.3% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 1/10 (10%) 2/10 (20%) 1/10 (10%) | 1/10 (10%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 16/39 (41%) 18/43 (42%) 14/41 (34%) 6/39 (15%) | 7/29 (24%) 8/28 (29%) 9/37 (24%) 12/44 (27%) |
|FIRST INCIDENCE (DAYS) | 458 (I) 458 (I) 457 (I) 456 (I) | 456 (I) 507 458 (I) 544 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.005N** P=0.443N P=0.302N P=0.010N* | P=0.120N P=0.567N P=0.260N P=0.171N |
|INCIDENTAL TUMOR | P=0.002N** P=0.490 P=0.427N P=0.007N** | P=0.535 P=0.546 P=0.519N P=0.468 |
|LOGISTIC REGRESSION | P=0.002N** P=0.552N P=0.322N P=0.004N** | P=0.500 P=0.529 P=0.421N P=0.412N |
|COCHRAN-ARMITAGE | P=0.002N** | P=0.457N |
|FISHER EXACT | P=0.574N P=0.352N P=0.007N** | P=0.583N P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 23/60 (38%) 23/60 (38%) 20/60 (33%) 10/60 (17%) | 15/60 (25%) 15/60 (25%) 14/60 (23%) 14/60 (23%) |
|ADJUSTED (b) | 49.5% 47.6% 41.9% 22.2% | 38.5% 39.6% 32.3% 30.3% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 1/10 (10%) 2/10 (20%) 1/10 (10%) | 1/10 (10%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 16/39 (41%) 18/43 (42%) 14/41 (34%) 6/39 (15%) | 7/29 (24%) 8/28 (29%) 9/37 (24%) 12/44 (27%) |
|FIRST INCIDENCE (DAYS) | 458 (I) 458 (I) 457 (I) 456 (I) | 456 (I) 507 458 (I) 544 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.005N** P=0.443N P=0.302N P=0.010N* | P=0.120N P=0.567N P=0.260N P=0.171N |
|INCIDENTAL TUMOR | P=0.002N** P=0.490 P=0.427N P=0.007N** | P=0.535 P=0.546 P=0.519N P=0.468 |
|LOGISTIC REGRESSION | P=0.002N** P=0.552N P=0.322N P=0.004N** | P=0.500 P=0.529 P=0.421N P=0.412N |
|COCHRAN-ARMITAGE | P=0.002N** | P=0.457N |
|FISHER EXACT | P=0.574N P=0.352N P=0.007N** | P=0.583N P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/16/94 EXPERIMENT: 05120 TEST: 04 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0% .033% .1% .3% | 0% .033% .1% .3% |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 10/60 (17%) 15/60 (25%) 8/60 (13%) 6/60 (10%) | 1/60 (2%) 5/60 (8%) 1/60 (2%) 5/60 (8%) |
|ADJUSTED (b) | 23.3% 33.9% 17.6% 15.4% | 3.4% 15.3% 2.6% 10.3% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 1/10 (10%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 7/39 (18%) 14/43 (33%) 5/41 (12%) 6/39 (15%) | 1/29 (3%) 3/28 (11%) 0/37 (0%) 3/44 (7%) |
|FIRST INCIDENCE (DAYS) | 458 (I) 508 457 (I) 729 (T) | 729 (T) 628 723 456 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.074N P=0.256 P=0.367N P=0.214N | P=0.330 P=0.109 P=0.703N P=0.185 |
|INCIDENTAL TUMOR | P=0.055N P=0.159 P=0.412N P=0.196N | P=0.167 P=0.085 P=0.697N P=0.150 |
|LOGISTIC REGRESSION | P=0.062N P=0.196 P=0.380N P=0.209N | P=0.193 P=0.111 P=0.695N P=0.104 |
|COCHRAN-ARMITAGE | P=0.061N | P=0.176 |
|FISHER EXACT | P=0.184 P=0.399N P=0.211N | P=0.103 P=0.752N P=0.103 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 3/60 (5%) 1/60 (2%) 3/60 (5%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 12.1% 7.0% 2.4% 6.8% | 0.0% 0.0% 2.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/39 (10%) 3/43 (7%) 1/41 (2%) 1/39 (3%) | 0/29 (0%) 0/28 (0%) 1/37 (3%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 508 729 (T) 729 (T) 457 (I) | --- --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.419N P=0.310N P=0.095N P=0.361N | P=0.719N (e) P=0.549 (e) |
|INCIDENTAL TUMOR | P=0.397N P=0.377N P=0.165N P=0.374N | P=0.719N (e) P=0.549 (e) |
|LOGISTIC REGRESSION | P=0.402N P=0.347N P=0.100N P=0.357N | P=0.720N (e) P=0.549 (e) |
|COCHRAN-ARMITAGE | P=0.400N | P=0.785N |
|FISHER EXACT | P=0.359N P=0.103N P=0.359N | (e) P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/16/94 EXPERIMENT: 05120 TEST: 04 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0% .033% .1% .3% | 0% .033% .1% .3% |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 15/60 (25%) 17/60 (28%) 9/60 (15%) 8/60 (13%) | 1/60 (2%) 5/60 (8%) 2/60 (3%) 5/60 (8%) |
|ADJUSTED (b) | 34.2% 38.5% 19.9% 19.1% | 3.4% 15.3% 5.2% 10.3% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 1/10 (10%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|TERMINAL (d) | 11/39 (28%) 16/43 (37%) 6/41 (15%) 6/39 (15%) | 1/29 (3%) 3/28 (11%) 1/37 (3%) 3/44 (7%) |
|FIRST INCIDENCE (DAYS) | 458 (I) 508 457 (I) 457 (I) | 729 (T) 628 723 456 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.042N* P=0.532 P=0.112N P=0.088N | P=0.361 P=0.109 P=0.586 P=0.185 |
|INCIDENTAL TUMOR | P=0.028N* P=0.370 P=0.173N P=0.080N | P=0.197 P=0.085 P=0.593 P=0.150 |
|LOGISTIC REGRESSION | P=0.032N* P=0.443 P=0.114N P=0.080N | P=0.212 P=0.111 P=0.608 P=0.104 |
|COCHRAN-ARMITAGE | P=0.032N* | P=0.190 |
|FISHER EXACT | P=0.418 P=0.127N P=0.082N | P=0.103 P=0.500 P=0.103 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/58 (5%) 0/59 (0%) 0/58 (0%) 1/57 (2%) | 9/58 (16%) 11/56 (20%) 4/60 (7%) 5/59 (8%) |
|ADJUSTED (b) | 7.9% 0.0% 0.0% 2.6% | 29.0% 36.3% 10.8% 10.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/38 (8%) 0/43 (0%) 0/39 (0%) 1/39 (3%) | 7/29 (24%) 9/27 (33%) 4/37 (11%) 4/44 (9%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- --- 729 (T) | 722 521 729 (T) 544 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.451N P=0.100N P=0.116N P=0.296N | P=0.014N* P=0.345 P=0.047N* P=0.051N |
|INCIDENTAL TUMOR | P=0.451N P=0.100N P=0.116N P=0.296N | P=0.037N* P=0.334 P=0.044N* P=0.202N |
|LOGISTIC REGRESSION | P=0.451N P=0.100N P=0.116N P=0.296N | P=0.040N* P=0.370 P=0.033N* P=0.104N |
|COCHRAN-ARMITAGE | P=0.451N | P=0.082N |
|FISHER EXACT | P=0.119N P=0.122N P=0.316N | P=0.370 P=0.107N P=0.187N |
|=================================================================================================================================|
DATE: 09/16/94 EXPERIMENT: 05120 TEST: 04 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0% .033% .1% .3% | 0% .033% .1% .3% |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/58 (5%) 0/59 (0%) 1/58 (2%) 1/57 (2%) | 9/58 (16%) 11/56 (20%) 4/60 (7%) 5/59 (8%) |
|ADJUSTED (b) | 7.9% 0.0% 2.0% 2.6% | 29.0% 36.3% 10.8% 10.9% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/38 (8%) 0/43 (0%) 0/39 (0%) 1/39 (3%) | 7/29 (24%) 9/27 (33%) 4/37 (11%) 4/44 (9%) |
|FIRST INCIDENCE (DAYS) | 729 (T) --- 571 729 (T) | 722 521 729 (T) 544 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.444N P=0.100N P=0.294N P=0.296N | P=0.014N* P=0.345 P=0.047N* P=0.051N |
|INCIDENTAL TUMOR | P=0.463N P=0.100N P=0.224N P=0.296N | P=0.037N* P=0.334 P=0.044N* P=0.202N |
|LOGISTIC REGRESSION | P=0.443N P=0.100N P=0.301N P=0.296N | P=0.040N* P=0.370 P=0.033N* P=0.104N |
|COCHRAN-ARMITAGE | P=0.445N | P=0.082N |
|FISHER EXACT | P=0.119N P=0.309N P=0.316N | P=0.370 P=0.107N P=0.187N |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibrosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/60 (0%) 0/60 (0%) 0/60 (0%) | 0/60 (0%) 2/60 (3%) 3/60 (5%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 6.0% 7.1% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/39 (0%) 0/43 (0%) 0/41 (0%) 0/39 (0%) | 0/29 (0%) 1/28 (4%) 0/37 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- 656 712 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.284N P=0.244 P=0.182 (e) |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.647 P=0.288 P=0.172 (e) |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.342N P=0.242 P=0.163 (e) |
|COCHRAN-ARMITAGE | (e) | P=0.385N |
|FISHER EXACT | (e) (e) (e) | P=0.248 P=0.122 (e) |
|=================================================================================================================================|
DATE: 09/16/94 EXPERIMENT: 05120 TEST: 04 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0% .033% .1% .3% | 0% .033% .1% .3% |
| | | |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) 2/60 (3%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 2.4% 2.1% 4.4% 0.0% | 0.0% 0.0% 2.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/39 (0%) 0/43 (0%) 1/41 (2%) 0/39 (0%) | 0/29 (0%) 0/28 (0%) 0/37 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | 725 589 618 --- | --- --- 722 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.340N P=0.753N P=0.516 P=0.505N | P=0.733N (e) P=0.556 (e) |
|INCIDENTAL TUMOR | P=0.311N P=0.703 P=0.538 P=0.464N | P=0.884 (e) P=0.564 (e) |
|LOGISTIC REGRESSION | P=0.332N P=0.761 P=0.506 P=0.503N | P=0.759N (e) P=0.553 (e) |
|COCHRAN-ARMITAGE | P=0.332N | P=0.785N |
|FISHER EXACT | P=0.752N P=0.500 P=0.500N | (e) P=0.500 (e) |
|=================================================================================================================================|
| |
|Spleen |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) 2/60 (3%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 4.2% 4.4% 2.1% | 0.0% 0.0% 2.7% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/39 (0%) 0/43 (0%) 1/41 (2%) 0/39 (0%) | 0/29 (0%) 0/28 (0%) 1/37 (3%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | --- 562 618 584 | --- --- 729 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.610 P=0.244 P=0.252 P=0.504 | P=0.719N (e) P=0.549 (e) |
|INCIDENTAL TUMOR | P=0.588 P=0.288 P=0.301 P=0.500 | P=0.719N (e) P=0.549 (e) |
|LOGISTIC REGRESSION | P=0.628N P=0.224 P=0.239 P=0.496 | P=0.720N (e) P=0.549 (e) |
|COCHRAN-ARMITAGE | P=0.615 | P=0.785N |
|FISHER EXACT | P=0.248 P=0.248 P=0.500 | (e) P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/16/94 EXPERIMENT: 05120 TEST: 04 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0% .033% .1% .3% | 0% .033% .1% .3% |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 4/60 (7%) 1/60 (2%) 3/60 (5%) | 0/60 (0%) 1/60 (2%) 2/60 (3%) 1/60 (2%) |
|ADJUSTED (b) | 7.3% 8.8% 2.4% 6.3% | 0.0% 3.6% 5.4% 2.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/39 (5%) 3/43 (7%) 1/41 (2%) 0/39 (0%) | 0/29 (0%) 1/28 (4%) 2/37 (5%) 1/44 (2%) |
|FIRST INCIDENCE (DAYS) | 670 508 729 (T) 457 (I) | --- 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.558N P=0.541 P=0.292N P=0.659 | P=0.635 P=0.493 P=0.293 P=0.583 |
|INCIDENTAL TUMOR | P=0.480N P=0.393 P=0.313N P=0.623N | P=0.635 P=0.493 P=0.293 P=0.583 |
|LOGISTIC REGRESSION | P=0.544N P=0.506 P=0.293N P=0.615N | P=0.635 P=0.493 P=0.293 P=0.583 |
|COCHRAN-ARMITAGE | P=0.544N | P=0.500 |
|FISHER EXACT | P=0.500 P=0.309N P=0.660N | P=0.500 P=0.248 P=0.500 |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 4/60 (7%) 1/60 (2%) 2/60 (3%) | 0/60 (0%) 1/60 (2%) 2/60 (3%) 1/60 (2%) |
|ADJUSTED (b) | 7.3% 8.8% 2.4% 4.1% | 0.0% 3.6% 5.4% 2.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/39 (5%) 3/43 (7%) 1/41 (2%) 0/39 (0%) | 0/29 (0%) 1/28 (4%) 2/37 (5%) 1/44 (2%) |
|FIRST INCIDENCE (DAYS) | 670 508 729 (T) 457 (I) | --- 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.352N P=0.541 P=0.292N P=0.500N | P=0.635 P=0.493 P=0.293 P=0.583 |
|INCIDENTAL TUMOR | P=0.310N P=0.393 P=0.313N P=0.467N | P=0.635 P=0.493 P=0.293 P=0.583 |
|LOGISTIC REGRESSION | P=0.338N P=0.506 P=0.293N P=0.501N | P=0.635 P=0.493 P=0.293 P=0.583 |
|COCHRAN-ARMITAGE | P=0.338N | P=0.500 |
|FISHER EXACT | P=0.500 P=0.309N P=0.500N | P=0.500 P=0.248 P=0.500 |
|=================================================================================================================================|
DATE: 09/16/94 EXPERIMENT: 05120 TEST: 04 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0% .033% .1% .3% | 0% .033% .1% .3% |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) 2/60 (3%) 1/60 (2%) | 2/60 (3%) 0/60 (0%) 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 5.1% 2.3% 4.9% 2.6% | 5.1% 0.0% 0.0% 2.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/39 (5%) 1/43 (2%) 2/41 (5%) 1/39 (3%) | 1/29 (3%) 0/28 (0%) 0/37 (0%) 1/44 (2%) |
|FIRST INCIDENCE (DAYS) | 729 (T) 729 (T) 729 (T) 729 (T) | 457 (I) --- --- 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.493N P=0.466N P=0.677N P=0.500N | P=0.564N P=0.244N P=0.213N P=0.404N |
|INCIDENTAL TUMOR | P=0.493N P=0.466N P=0.677N P=0.500N | P=0.564N P=0.244N P=0.213N P=0.404N |
|LOGISTIC REGRESSION | P=0.493N P=0.466N P=0.677N P=0.500N | P=0.652N P=0.227N P=0.243N P=0.507N |
|COCHRAN-ARMITAGE | P=0.477N | P=0.646N |
|FISHER EXACT | P=0.500N P=0.691N P=0.500N | P=0.248N P=0.248N P=0.500N |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 8/60 (13%) 2/60 (3%) 1/60 (2%) 6/60 (10%) |
|ADJUSTED (b) | | 25.2% 7.1% 2.7% 13.6% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | | 6/29 (21%) 2/28 (7%) 1/37 (3%) 6/44 (14%) |
|FIRST INCIDENCE (DAYS) | | 656 729 (T) 729 (T) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.411N P=0.050N P=0.006N** P=0.139N |
|INCIDENTAL TUMOR | | P=0.529N P=0.036N* P=0.006N** P=0.319N |
|LOGISTIC REGRESSION | | P=0.547N P=0.038N* P=0.006N** P=0.223N |
|COCHRAN-ARMITAGE | | P=0.478 |
|FISHER EXACT | | P=0.047N* P=0.016N* P=0.389N |
|=================================================================================================================================|
DATE: 09/16/94 EXPERIMENT: 05120 TEST: 04 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0% .033% .1% .3% | 0% .033% .1% .3% |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/60 (0%) 1/60 (2%) 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | | 0.0% 2.2% 4.4% 0.0% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | | 0/29 (0%) 0/28 (0%) 1/37 (3%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | | --- 544 457 (I) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.469N P=0.504 P=0.266 (e) |
|INCIDENTAL TUMOR | | P=0.619N P=0.464 P=0.266 (e) |
|LOGISTIC REGRESSION | | P=0.541N P=0.528 P=0.231 (e) |
|COCHRAN-ARMITAGE | | P=0.516N |
|FISHER EXACT | | P=0.500 P=0.248 (e) |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 8/60 (13%) 3/60 (5%) 3/60 (5%) 6/60 (10%) |
|ADJUSTED (b) | | 25.2% 9.2% 7.0% 13.6% |
|INTERIM SACRIFICE 1 (c)| | 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | | 6/29 (21%) 2/28 (7%) 2/37 (5%) 6/44 (14%) |
|FIRST INCIDENCE (DAYS) | | 656 544 457 (I) 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.333N P=0.106N P=0.048N* P=0.139N |
|INCIDENTAL TUMOR | | P=0.492N P=0.087N P=0.046N* P=0.319N |
|LOGISTIC REGRESSION | | P=0.535N P=0.090N P=0.070N P=0.223N |
|COCHRAN-ARMITAGE | | P=0.553 |
|FISHER EXACT | | P=0.102N P=0.102N P=0.389N |
|=================================================================================================================================|
DATE: 09/16/94 EXPERIMENT: 05120 TEST: 04 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0% .033% .1% .3% | 0% .033% .1% .3% |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/60 (2%) 0/60 (0%) 0/60 (0%) | 2/60 (3%) 1/60 (2%) 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 2.3% 0.0% 0.0% | 6.9% 3.6% 0.0% 0.0% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/39 (0%) 1/43 (2%) 0/41 (0%) 0/39 (0%) | 2/29 (7%) 1/28 (4%) 0/37 (0%) 0/44 (0%) |
|FIRST INCIDENCE (DAYS) | --- 729 (T) --- --- | 729 (T) 729 (T) --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.592N P=0.519 (e) (e) | P=0.113N P=0.512N P=0.186N P=0.152N |
|INCIDENTAL TUMOR | P=0.592N P=0.519 (e) (e) | P=0.113N P=0.512N P=0.186N P=0.152N |
|LOGISTIC REGRESSION | P=0.592N P=0.519 (e) (e) | P=0.113N P=0.512N P=0.186N P=0.152N |
|COCHRAN-ARMITAGE | P=0.584N | P=0.169N |
|FISHER EXACT | P=0.500 (e) (e) | P=0.500N P=0.248N P=0.248N |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 2/60 (3%) 5/60 (8%) 2/60 (3%) | 0/60 (0%) 0/60 (0%) 4/60 (7%) 1/60 (2%) |
|ADJUSTED (b) | 4.9% 4.2% 11.1% 4.5% | 0.0% 0.0% 10.3% 2.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/39 (3%) 0/43 (0%) 3/41 (7%) 0/39 (0%) | 0/29 (0%) 0/28 (0%) 3/37 (8%) 1/44 (2%) |
|FIRST INCIDENCE (DAYS) | 725 562 618 584 | --- --- 722 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.592N P=0.675N P=0.242 P=0.689 | P=0.562 (e) P=0.101 P=0.583 |
|INCIDENTAL TUMOR | P=0.572N P=0.687 P=0.276 P=0.663N | P=0.442 (e) P=0.103 P=0.583 |
|LOGISTIC REGRESSION | P=0.492N P=0.704N P=0.226 P=0.694N | P=0.525 (e) P=0.108 P=0.583 |
|COCHRAN-ARMITAGE | P=0.579N | P=0.410 |
|FISHER EXACT | P=0.691N P=0.219 P=0.691N | (e) P=0.059 P=0.500 |
|=================================================================================================================================|
DATE: 09/16/94 EXPERIMENT: 05120 TEST: 04 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0% .033% .1% .3% | 0% .033% .1% .3% |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 3/60 (5%) 5/60 (8%) 2/60 (3%) | 2/60 (3%) 1/60 (2%) 4/60 (7%) 1/60 (2%) |
|ADJUSTED (b) | 4.9% 6.4% 11.1% 4.5% | 6.9% 3.6% 10.3% 2.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/39 (3%) 1/43 (2%) 3/41 (7%) 0/39 (0%) | 2/29 (7%) 1/28 (4%) 3/37 (8%) 1/44 (2%) |
|FIRST INCIDENCE (DAYS) | 725 562 618 584 | 729 (T) 729 (T) 722 729 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.515N P=0.526 P=0.242 P=0.689 | P=0.281N P=0.512N P=0.457 P=0.356N |
|INCIDENTAL TUMOR | P=0.489N P=0.491 P=0.276 P=0.663N | P=0.354N P=0.512N P=0.460 P=0.356N |
|LOGISTIC REGRESSION | P=0.412N P=0.500 P=0.226 P=0.694N | P=0.310N P=0.512N P=0.485 P=0.356N |
|COCHRAN-ARMITAGE | P=0.500N | P=0.459N |
|FISHER EXACT | P=0.500 P=0.219 P=0.691N | P=0.500N P=0.340 P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 3/60 (5%) 2/60 (3%) 1/60 (2%) | 8/60 (13%) 8/60 (13%) 9/60 (15%) 10/60 (17%) |
|ADJUSTED (b) | 4.4% 7.0% 4.4% 2.6% | 23.3% 24.9% 22.8% 21.3% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/39 (0%) 3/43 (7%) 0/41 (0%) 1/39 (3%) | 5/29 (17%) 5/28 (18%) 7/37 (19%) 8/44 (18%) |
|FIRST INCIDENCE (DAYS) | 577 729 (T) 618 729 (T) | 494 681 716 302 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.319N P=0.530 P=0.676N P=0.505N | P=0.413N P=0.589 P=0.512N P=0.508N |
|INCIDENTAL TUMOR | P=0.270N P=0.474 P=0.654N P=0.479N | P=0.348 P=0.544N P=0.492 P=0.497 |
|LOGISTIC REGRESSION | P=0.305N P=0.507 P=0.692 P=0.500N | P=0.413 P=0.588N P=0.587N P=0.431 |
|COCHRAN-ARMITAGE | P=0.303N | P=0.333 |
|FISHER EXACT | P=0.500 P=0.691N P=0.500N | P=0.605N P=0.500 P=0.399 |
|=================================================================================================================================|
DATE: 09/16/94 EXPERIMENT: 05120 TEST: 04 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0% .033% .1% .3% | 0% .033% .1% .3% |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 3/60 (5%) 2/60 (3%) 1/60 (2%) | 8/60 (13%) 7/60 (12%) 9/60 (15%) 9/60 (15%) |
|ADJUSTED (b) | 4.4% 7.0% 4.4% 2.6% | 23.3% 22.8% 22.8% 19.5% |
|INTERIM SACRIFICE 1 (c)| 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/39 (0%) 3/43 (7%) 0/41 (0%) 1/39 (3%) | 5/29 (17%) 5/28 (18%) 7/37 (19%) 8/44 (18%) |
|FIRST INCIDENCE (DAYS) | 577 729 (T) 618 729 (T) | 494 691 716 302 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.319N P=0.530 P=0.676N P=0.505N | P=0.350N P=0.521N P=0.512N P=0.407N |
|INCIDENTAL TUMOR | P=0.270N P=0.474 P=0.654N P=0.479N | P=0.472 P=0.460N P=0.492 P=0.590N |
|LOGISTIC REGRESSION | P=0.305N P=0.507 P=0.692 P=0.500N | P=0.493 P=0.479N P=0.587N P=0.441N |
|COCHRAN-ARMITAGE | P=0.303N | P=0.399 |
|FISHER EXACT | P=0.500 P=0.691N P=0.500N | P=0.500N P=0.500 P=0.500 |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 30/60 (50%) 28/60 (47%) 24/60 (40%) 17/60 (28%) | 32/60 (53%) 29/60 (48%) 17/60 (28%) 24/60 (40%) |
|ADJUSTED (b) | 66.3% 62.0% 49.4% 37.1% | 81.1% 75.2% 39.8% 48.6% |
|INTERIM SACRIFICE 1 (c)| 2/10 (20%) 1/10 (10%) 3/10 (30%) 2/10 (20%) | 3/10 (30%) 0/10 (0%) 1/10 (10%) 2/10 (20%) |
|TERMINAL (d) | 24/39 (62%) 26/43 (60%) 17/41 (41%) 11/39 (28%) | 22/29 (76%) 19/28 (68%) 12/37 (32%) 19/44 (43%) |
|FIRST INCIDENCE (DAYS) | 457 (I) 458 (I) 457 (I) 456 (I) | 456 (I) 507 458 (I) 456 (I) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.012N* P=0.250N P=0.139N P=0.016N* | P=0.002N** P=0.392N P<0.001N** P=0.002N** |
|INCIDENTAL TUMOR | P=0.003N** P=0.403N P=0.153N P=0.006N** | P=0.056N P=0.360N P<0.001N** P=0.044N* |
|LOGISTIC REGRESSION | P=0.006N** P=0.376N P=0.138N P=0.010N** | P=0.053N P=0.315N P<0.001N** P=0.052N |
|COCHRAN-ARMITAGE | P=0.007N** | P=0.112N |
|FISHER EXACT | P=0.428N P=0.179N P=0.012N* | P=0.358N P=0.004N** P=0.100N |
|=================================================================================================================================|
DATE: 09/16/94 EXPERIMENT: 05120 TEST: 04 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0% .033% .1% .3% | 0% .033% .1% .3% |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 25/60 (42%) 21/60 (35%) 20/60 (33%) 15/60 (25%) | 17/60 (28%) 24/60 (40%) 25/60 (42%) 16/60 (27%) |
|ADJUSTED (b) | 50.8% 42.8% 40.6% 31.5% | 42.8% 56.4% 50.6% 33.7% |
|INTERIM SACRIFICE 1 (c)| 1/10 (10%) 0/10 (0%) 0/10 (0%) 1/10 (10%) | 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|TERMINAL (d) | 15/39 (38%) 15/43 (35%) 12/41 (29%) 7/39 (18%) | 8/29 (28%) 11/28 (39%) 13/37 (35%) 13/44 (30%) |
|FIRST INCIDENCE (DAYS) | 458 (I) 508 571 457 (I) | 494 17 114 302 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.075N P=0.214N P=0.202N P=0.062N | P=0.025N* P=0.163 P=0.353 P=0.163N |
|INCIDENTAL TUMOR | P=0.015N* P=0.397N P=0.197N P=0.023N* | P=0.470N P=0.143 P=0.071 P=0.508 |
|LOGISTIC REGRESSION | P=0.013N* P=0.270N P=0.172N P=0.016N* | P=0.134N P=0.122 P=0.119 P=0.443N |
|COCHRAN-ARMITAGE | P=0.042N* | P=0.212N |
|FISHER EXACT | P=0.287N P=0.225N P=0.040N* | P=0.124 P=0.090 P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 45/60 (75%) 41/60 (68%) 38/60 (63%) 25/60 (42%) | 38/60 (63%) 40/60 (67%) 35/60 (58%) 35/60 (58%) |
|ADJUSTED (b) | 86.5% 81.9% 71.6% 50.7% | 85.7% 86.7% 69.7% 67.1% |
|INTERIM SACRIFICE 1 (c)| 3/10 (30%) 1/10 (10%) 3/10 (30%) 2/10 (20%) | 3/10 (30%) 0/10 (0%) 2/10 (20%) 2/10 (20%) |
|TERMINAL (d) | 32/39 (82%) 34/43 (79%) 26/41 (63%) 15/39 (38%) | 23/29 (79%) 22/28 (79%) 22/37 (59%) 27/44 (61%) |
|FIRST INCIDENCE (DAYS) | 457 (I) 458 (I) 457 (I) 456 (I) | 456 (I) 17 114 302 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001N** P=0.128N P=0.107N P=0.002N** | P=0.003N** P=0.427 P=0.060N P=0.014N* |
|INCIDENTAL TUMOR | P<0.001N** P=0.272N P=0.077N P<0.001N** | P=0.310N P=0.526 P=0.167N P=0.333N |
|LOGISTIC REGRESSION | P<0.001N** P=0.185N P=0.078N P<0.001N** | P=0.114N P=0.527 P=0.232N P=0.262N |
|COCHRAN-ARMITAGE | P<0.001N** | P=0.247N |
|FISHER EXACT | P=0.272N P=0.118N P<0.001N** | P=0.424 P=0.354N P=0.354N |
|=================================================================================================================================|
DATE: 09/16/94 EXPERIMENT: 05120 TEST: 04 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- BENZYL ACETATE
TERMINAL SACRIFICE AT 105 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(c) Observed incidence at interim kill.
Male interim sacrifices(days): 456
Female interim sacrifices(days): 456
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).