TDMS Study 05120-03 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
BENZYL ACETATE
NTP Experiment-Test: 05120-03 Report: PEIRPT03
Study Type: CHRONIC Date: 09/15/94
Route: DOSED FEED Time: 13:33:56
Facility: Southern Research Institute
Chemical CAS #: 140-11-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/15/94
Route: DOSED FEED Time: 13:33:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0% 0.3% 0.6% 1.2%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund Sacrifice 18 17 13 19
Natural Death 2 3 3
Survivors
Terminal Sacrifice 30 30 37 28
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (60) (60) (60) (60)
Parasite Metazoan 2 (3%) 1 (2%) 4 (7%) 4 (7%)
Intestine Large, Rectum (59) (59) (60) (59)
Parasite Metazoan 5 (8%) 6 (10%) 1 (2%) 3 (5%)
Intestine Small, Jejunum (59) (60) (60) (60)
Dilatation 1 (2%)
Inflammation, Chronic 1 (2%)
Ulcer 1 (2%)
Liver (60) (60) (60) (60)
Angiectasis 1 (2%) 1 (2%) 2 (3%)
Congestion 1 (2%)
Cyst 1 (2%)
Degeneration, Cystic 3 (5%)
Fatty Change 22 (37%) 17 (28%) 18 (30%) 22 (37%)
Fibrosis, Focal 1 (2%) 1 (2%)
Focal Cellular Change 38 (63%) 44 (73%) 42 (70%) 45 (75%)
Hematopoietic Cell Proliferation 2 (3%) 2 (3%) 1 (2%)
Hepatodiaphragmatic Nodule 12 (20%) 12 (20%) 5 (8%) 7 (12%)
Hyperplasia, Multifocal 21 (35%) 16 (27%) 9 (15%) 13 (22%)
Infiltration Cellular, Mixed Cell 1 (2%) 5 (8%) 3 (5%) 2 (3%)
Inflammation, Focal 45 (75%) 53 (88%) 49 (82%) 44 (73%)
Necrosis, Focal 3 (5%) 1 (2%) 2 (3%) 1 (2%)
Pigmentation 1 (2%)
Bile Duct, Hyperplasia 43 (72%) 37 (62%) 38 (63%) 41 (68%)
Biliary Tract, Fibrosis 29 (48%) 23 (38%) 25 (42%) 19 (32%)
Centrilobular, Atrophy 6 (10%) 4 (7%) 9 (15%) 7 (12%)
Mesentery (11) (5) (7) (12)
Inflammation, Chronic 1 (14%)
Fat, Necrosis 7 (64%) 4 (80%) 2 (29%) 7 (58%)
Pancreas (60) (60) (60) (60)
Atrophy, Focal 16 (27%) 20 (33%) 29 (48%) 19 (32%)
Focal Cellular Change 4 (7%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/15/94
Route: DOSED FEED Time: 13:33:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0% 0.3% 0.6% 1.2%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Infiltration Cellular, Lipocyte 1 (2%)
Acinar Cell, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Duct, Dilatation 1 (2%) 1 (2%) 1 (2%)
Salivary Glands (60) (60) (60) (60)
Atrophy, Focal 1 (2%) 1 (2%)
Focal Cellular Change 1 (2%)
Infiltration Cellular, Lipocyte 1 (2%)
Stomach, Forestomach (60) (60) (60) (60)
Edema 1 (2%) 2 (3%)
Erosion 1 (2%)
Inflammation, Chronic 1 (2%) 3 (5%) 3 (5%)
Ulcer 3 (5%) 1 (2%)
Mucosa, Hyperplasia 2 (3%) 2 (3%)
Stomach, Glandular (60) (60) (60) (60)
Developmental Malformation 1 (2%)
Edema 1 (2%) 1 (2%)
Erosion 3 (5%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Ulcer 1 (2%)
Mucosa, Cyst, Multiple 1 (2%)
Tooth (1) (3) (1)
Incisor, Dysplasia 1 (33%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1)
Mesenteric Artery, Inflammation, Chronic 1 (100%) 1 (100%)
Mesenteric Artery, Thrombosis 1 (100%)
Thoracic, Artery, Aneurysm 1 (100%)
Thoracic, Artery, Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (60) (60) (60)
Accessory Adrenal Cortical Nodule 1 (2%) 2 (3%)
Angiectasis 1 (2%) 1 (2%)
Congestion 3 (5%) 1 (2%)
Focal Cellular Change 10 (17%) 6 (10%) 7 (12%) 5 (8%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Focal 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%) 1 (2%)
Adrenal Gland, Medulla (60) (60) (60) (60)
Cyst 1 (2%)
Fibrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/15/94
Route: DOSED FEED Time: 13:33:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0% 0.3% 0.6% 1.2%
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 3 (5%) 4 (7%) 1 (2%) 5 (8%)
Parathyroid Gland (58) (60) (59) (57)
Cyst 1 (2%)
Pituitary Gland (60) (60) (60) (60)
Angiectasis 1 (2%) 6 (10%) 5 (8%) 4 (7%)
Cyst 5 (8%) 3 (5%) 9 (15%) 10 (17%)
Hemorrhage 1 (2%)
Pars Distalis, Focal Cellular Change 1 (2%) 3 (5%) 8 (13%) 3 (5%)
Pars Distalis, Hyperplasia, Focal 2 (3%) 3 (5%)
Thyroid Gland (60) (60) (60) (59)
Ultimobranchial Cyst 1 (2%) 2 (3%) 1 (2%)
C-Cell, Hyperplasia 17 (28%) 10 (17%) 14 (23%) 10 (17%)
Follicle, Cyst 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (60) (60) (60) (59)
Degeneration, Cystic 51 (85%) 54 (90%) 48 (80%) 47 (80%)
Hyperplasia 2 (3%) 1 (2%) 1 (2%) 4 (7%)
Inflammation, Chronic 2 (3%) 1 (2%) 1 (2%)
Ovary (60) (60) (60) (59)
Angiectasis 2 (3%)
Hyperplasia, Histiocytic 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Necrosis, Focal 1 (2%)
Follicle, Cyst 6 (10%) 1 (2%) 2 (3%) 4 (7%)
Periovarian Tissue, Cyst 1 (2%) 1 (2%) 1 (2%)
Uterus (60) (60) (60) (60)
Adenomyosis 1 (2%)
Cyst 1 (2%)
Decidual Reaction 1 (2%) 1 (2%)
Dilatation 1 (2%)
Hemorrhage 1 (2%)
Hydrometra 4 (7%) 5 (8%) 3 (5%) 4 (7%)
Inflammation, Suppurative 4 (7%) 3 (5%) 4 (7%) 2 (3%)
Prolapse 1 (2%)
Cervix, Hyperplasia 1 (2%)
Endometrium, Angiectasis 1 (2%)
Endometrium, Hyperplasia, Cystic 34 (57%) 38 (63%) 40 (67%) 43 (72%)
Endometrium, Infarct 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/15/94
Route: DOSED FEED Time: 13:33:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0% 0.3% 0.6% 1.2%
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Epithelium, Hyperplasia, Papillary 3 (5%) 1 (2%) 1 (2%) 1 (2%)
Lumen, Exudate 1 (2%)
Vagina (2) (1) (2) (2)
Angiectasis 1 (50%)
Cyst 1 (50%) 1 (100%) 1 (50%) 1 (50%)
Mucosa, Hyperplasia 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Hypercellularity 1 (2%) 1 (2%)
Hyperplasia, Histiocytic 1 (2%)
Lymph Node (60) (60) (60) (60)
Axillary, Angiectasis 1 (2%)
Axillary, Hyperplasia 1 (2%)
Deep Cervical, Hyperplasia 1 (2%)
Mediastinal, Angiectasis 1 (2%) 4 (7%) 1 (2%) 2 (3%)
Mediastinal, Pigmentation 1 (2%)
Pancreatic, Angiectasis 1 (2%)
Pancreatic, Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Mandibular (60) (60) (60) (59)
Angiectasis 1 (2%) 2 (3%) 3 (5%)
Hyperplasia 1 (2%) 3 (5%)
Lymph Node, Mesenteric (60) (60) (60) (59)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Cyst 1 (2%)
Depletion Lymphoid 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Spleen (60) (60) (60) (60)
Developmental Malformation 1 (2%)
Fibrosis 4 (7%) 3 (5%) 3 (5%) 6 (10%)
Hematopoietic Cell Proliferation 4 (7%) 6 (10%) 3 (5%) 5 (8%)
Hyperplasia, Histiocytic 2 (3%)
Hyperplasia, Lymphoid 2 (3%)
Necrosis, Focal 1 (2%)
Thymus (59) (54) (59) (60)
Angiectasis 1 (2%)
Cyst 4 (7%) 1 (2%) 1 (2%) 1 (2%)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/15/94
Route: DOSED FEED Time: 13:33:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0% 0.3% 0.6% 1.2%
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (60) (60) (60)
Dilatation 41 (68%) 36 (60%) 34 (57%) 35 (58%)
Fibrosis 1 (2%) 1 (2%)
Hyperplasia 10 (17%) 8 (13%) 7 (12%) 6 (10%)
Skin (60) (60) (60) (60)
Hyperkeratosis, Focal 1 (2%) 1 (2%)
Subcutaneous Tissue, Inflammation,
Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Hyperostosis 12 (20%) 21 (35%) 12 (20%) 22 (37%)
Adventitia, Mandible, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Compression 16 (27%) 13 (22%) 8 (13%) 12 (20%)
Hemorrhage 2 (3%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Bronchiectasis 1 (2%)
Congestion 1 (2%) 2 (3%) 1 (2%)
Fibrosis, Focal 1 (2%) 1 (2%)
Granuloma 1 (2%)
Hemorrhage 1 (2%) 2 (3%) 2 (3%)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Macrophage 1 (2%) 6 (10%) 1 (2%) 1 (2%)
Inflammation, Chronic 2 (3%) 1 (2%)
Pigmentation 2 (3%)
Alveolar Epithelium, Hyperplasia 3 (5%) 3 (5%) 4 (7%) 2 (3%)
Nose (60) (60) (60) (60)
Fungus 8 (13%) 3 (5%) 3 (5%)
Hemorrhage 1 (2%)
Inflammation, Suppurative 14 (23%) 9 (15%) 16 (27%) 13 (22%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/15/94
Route: DOSED FEED Time: 13:33:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0% 0.3% 0.6% 1.2%
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (4) (2)
Atrophy 1 (50%)
Cataract 4 (100%) 2 (100%)
Hemorrhage 1 (50%)
Inflammation, Chronic 1 (50%)
Cornea, Necrosis 1 (50%)
Retina, Degeneration 1 (50%) 3 (75%) 2 (100%)
Harderian Gland (1) (1) (1)
Dilatation, Focal 1 (100%)
Inflammation, Focal 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Cyst 1 (2%) 1 (2%)
Fibrosis 1 (2%)
Mineralization 9 (15%) 11 (18%) 9 (15%) 10 (17%)
Necrosis, Focal 1 (2%)
Nephropathy 48 (80%) 55 (92%) 47 (78%) 44 (73%)
Pigmentation 1 (2%) 1 (2%)
Papilla, Necrosis 1 (2%)
Pelvis, Dilatation 1 (2%) 1 (2%)
Renal Tubule, Dilatation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/15/94
Route: DOSED FEED Time: 13:33:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0% 0.3% 0.6% 1.2%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund Sacrifice 20 12 16 14
Natural Death 3 4 4 3
Survivors
Terminal Sacrifice 27 34 30 33
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (60) (60) (60) (59)
Parasite Metazoan 1 (2%) 1 (2%)
Intestine Large, Colon (60) (60) (59) (59)
Cyst 1 (2%)
Parasite Metazoan 4 (7%) 8 (13%) 2 (3%) 3 (5%)
Intestine Large, Rectum (59) (60) (59) (58)
Parasite Metazoan 5 (8%) 2 (3%) 3 (5%) 7 (12%)
Intestine Small, Ileum (59) (60) (60) (59)
Congestion 1 (2%)
Inflammation, Chronic 1 (2%)
Intestine Small, Jejunum (59) (60) (60) (58)
Diverticulum 1 (2%)
Inflammation, Chronic 1 (2%)
Metaplasia, Osseous 1 (2%)
Mucosa, Dysplasia 1 (2%)
Liver (60) (60) (60) (60)
Angiectasis 4 (7%) 2 (3%)
Congestion 1 (2%) 1 (2%)
Degeneration, Cystic 17 (28%) 20 (33%) 14 (23%) 14 (23%)
Fatty Change 36 (60%) 37 (62%) 33 (55%) 35 (58%)
Fibrosis, Focal 1 (2%) 1 (2%)
Focal Cellular Change 27 (45%) 29 (48%) 28 (47%) 29 (48%)
Hematopoietic Cell Proliferation 3 (5%)
Hemorrhage 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 9 (15%) 6 (10%) 4 (7%) 4 (7%)
Hyperplasia, Multifocal 16 (27%) 17 (28%) 11 (18%) 18 (30%)
Infiltration Cellular, Mixed Cell 7 (12%) 5 (8%) 5 (8%) 7 (12%)
Inflammation, Focal 44 (73%) 36 (60%) 37 (62%) 38 (63%)
Necrosis, Focal 1 (2%) 1 (2%) 3 (5%) 2 (3%)
Pigmentation 1 (2%)
Thrombosis 1 (2%)
Bile Duct, Dilatation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/15/94
Route: DOSED FEED Time: 13:33:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0% 0.3% 0.6% 1.2%
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Bile Duct, Hyperplasia 56 (93%) 60 (100%) 59 (98%) 60 (100%)
Biliary Tract, Fibrosis 54 (90%) 55 (92%) 57 (95%) 58 (97%)
Centrilobular, Atrophy 13 (22%) 14 (23%) 15 (25%) 10 (17%)
Centrilobular, Necrosis 1 (2%) 3 (5%) 1 (2%)
Mesentery (17) (16) (13) (11)
Inflammation, Chronic 1 (6%) 2 (13%) 1 (9%)
Fat, Necrosis 12 (71%) 9 (56%) 10 (77%) 9 (82%)
Pancreas (60) (60) (60) (59)
Atrophy, Focal 32 (53%) 32 (53%) 30 (50%) 30 (51%)
Focal Cellular Change 6 (10%) 4 (7%)
Acinar Cell, Hyperplasia 3 (5%) 1 (2%) 7 (12%) 3 (5%)
Salivary Glands (60) (60) (60) (59)
Atrophy, Focal 1 (2%)
Dilatation 1 (2%)
Focal Cellular Change 1 (2%)
Hyperplasia 1 (2%)
Stomach, Forestomach (60) (60) (60) (60)
Edema 1 (2%) 1 (2%) 1 (2%)
Erosion 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 5 (8%) 2 (3%) 1 (2%)
Ulcer 1 (2%) 2 (3%) 1 (2%) 1 (2%)
Mucosa, Hyperplasia 3 (5%) 5 (8%) 3 (5%) 3 (5%)
Stomach, Glandular (60) (60) (60) (60)
Edema 2 (3%) 1 (2%) 1 (2%) 1 (2%)
Erosion 3 (5%) 1 (2%) 3 (5%) 3 (5%)
Hyperplasia, Lymphoid 3 (5%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Pigmentation 1 (2%) 2 (3%)
Ulcer 1 (2%)
Mucosa, Pigmentation 1 (2%)
Tongue (60) (60) (59) (60)
Ectopic Tissue 1 (2%)
Mucosa, Hyperplasia 1 (2%)
Tooth (2) (1)
Incisor, Dysplasia 1 (50%) 1 (100%)
Incisor, Inflammation, Suppurative 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (3) (3) (1) (6)
Mesenteric Artery, Inflammation, Chronic 3 (100%) 3 (100%) 1 (100%) 5 (83%)
Thoracic, Artery, Inflammation, Chronic 1 (17%)
Heart (60) (60) (60) (60)
Dilatation 1 (2%)
Thrombosis 2 (3%) 2 (3%) 2 (3%)
Artery, Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/15/94
Route: DOSED FEED Time: 13:33:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0% 0.3% 0.6% 1.2%
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Epicardium, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (60) (60) (60)
Accessory Adrenal Cortical Nodule 2 (3%) 1 (2%)
Angiectasis 1 (2%)
Congestion 1 (2%) 1 (2%)
Focal Cellular Change 9 (15%) 6 (10%) 7 (12%) 6 (10%)
Hematopoietic Cell Proliferation 1 (2%)
Vacuolization Cytoplasmic 2 (3%)
Adrenal Gland, Medulla (60) (60) (60) (60)
Angiectasis 1 (2%)
Fibrosis 1 (2%)
Hyperplasia 12 (20%) 12 (20%) 16 (27%) 13 (22%)
Mineralization 1 (2%)
Parathyroid Gland (60) (55) (58) (58)
Hyperplasia 2 (3%) 1 (2%)
Pituitary Gland (59) (60) (59) (58)
Angiectasis 2 (3%) 1 (2%) 1 (2%)
Cyst 3 (5%) 3 (5%) 4 (7%) 1 (2%)
Hemorrhage 2 (3%)
Pars Distalis, Focal Cellular Change 5 (8%) 4 (7%) 7 (12%) 6 (10%)
Pars Distalis, Hyperplasia, Focal 1 (2%) 2 (3%) 2 (3%) 3 (5%)
Pars Distalis, Vacuolization Cytoplasmic 1 (2%)
Pars Nervosa, Focal Cellular Change 1 (2%)
Rathke's Cleft, Hyperplasia, Cystic 1 (2%)
Thyroid Gland (60) (59) (60) (58)
Degeneration, Cystic 1 (2%)
Fibrosis, Focal 1 (2%)
Pigmentation 1 (2%) 1 (2%)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia 4 (7%) 5 (8%) 6 (10%) 7 (12%)
Follicle, Cyst 3 (5%) 2 (3%) 2 (3%)
Follicular Cell, Hyperplasia 2 (3%) 2 (3%) 3 (5%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1) (2) (1)
Thoracic, Metaplasia, Osseous 1 (50%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/15/94
Route: DOSED FEED Time: 13:33:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0% 0.3% 0.6% 1.2%
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (60) (60) (60)
Atrophy 1 (2%)
Preputial Gland (60) (60) (60) (60)
Degeneration, Cystic 54 (90%) 60 (100%) 59 (98%) 60 (100%)
Hyperplasia 1 (2%) 3 (5%)
Inflammation, Chronic 1 (2%) 1 (2%) 4 (7%) 3 (5%)
Prostate (60) (60) (60) (60)
Dilatation 2 (3%) 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 6 (10%) 2 (3%) 1 (2%)
Inflammation, Suppurative 37 (62%) 27 (45%) 26 (43%) 28 (47%)
Vacuolization Cytoplasmic 1 (2%)
Seminal Vesicle (60) (60) (60) (60)
Dilatation 3 (5%) 1 (2%)
Testes (60) (60) (60) (60)
Germinal Epithelium, Degeneration 10 (17%) 7 (12%) 8 (13%) 11 (18%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (59)
Hypercellularity 3 (5%)
Hypocellularity 1 (2%) 1 (2%)
Myelofibrosis 1 (2%) 1 (2%)
Lymph Node (60) (60) (60) (59)
Cyst 1 (2%)
Mediastinal, Angiectasis 4 (7%) 2 (3%) 5 (8%) 1 (2%)
Mediastinal, Hemorrhage 1 (2%)
Mediastinal, Hyperplasia 1 (2%)
Mediastinal, Pigmentation 1 (2%)
Pancreatic, Angiectasis 1 (2%)
Pancreatic, Cyst 1 (2%)
Lymph Node, Mandibular (60) (59) (60) (58)
Angiectasis 2 (3%) 1 (2%) 2 (3%) 1 (2%)
Cyst 1 (2%) 3 (5%) 2 (3%)
Edema 1 (2%)
Hyperplasia 3 (5%) 2 (3%)
Lymph Node, Mesenteric (60) (60) (58) (59)
Angiectasis 1 (2%) 2 (3%)
Cyst 1 (2%) 2 (3%) 3 (5%)
Hyperplasia 1 (2%) 1 (2%)
Spleen (60) (60) (60) (60)
Congestion 1 (2%)
Developmental Malformation 1 (2%)
Fibrosis 10 (17%) 12 (20%) 10 (17%) 8 (13%)
Hematopoietic Cell Proliferation 3 (5%) 6 (10%) 2 (3%) 3 (5%)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/15/94
Route: DOSED FEED Time: 13:33:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0% 0.3% 0.6% 1.2%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Histiocytic 1 (2%) 2 (3%)
Necrosis, Focal 2 (3%) 1 (2%) 2 (3%)
Thymus (58) (58) (58) (55)
Cyst 3 (5%) 1 (2%) 1 (2%)
Depletion Cellular 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (58) (58) (58) (60)
Dilatation 7 (12%) 8 (14%) 8 (14%) 8 (13%)
Fibrosis 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Hyperplasia 2 (3%) 1 (2%) 1 (2%) 3 (5%)
Skin (60) (60) (60) (60)
Cyst Epithelial Inclusion 1 (2%)
Edema 1 (2%)
Exudate 1 (2%)
Hemorrhage 1 (2%)
Hyperkeratosis, Focal 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic 2 (3%) 1 (2%)
Ulcer 2 (3%)
Epidermis, Hyperplasia 1 (2%) 1 (2%)
Subcutaneous Tissue, Fat, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Hyperostosis 1 (2%) 1 (2%)
Trabecula, Proliferation 1 (2%)
Skeletal Muscle (60) (60) (60) (60)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
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NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Compression 3 (5%) 2 (3%) 1 (2%) 2 (3%)
Hemorrhage 2 (3%) 2 (3%) 1 (2%) 1 (2%)
Hydrocephalus 2 (3%)
Meninges, Angiectasis 1 (2%)
Meninges, Hemorrhage 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/15/94
Route: DOSED FEED Time: 13:33:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0% 0.3% 0.6% 1.2%
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RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Congestion 1 (2%)
Exudate 1 (2%)
Fibrosis, Focal 1 (2%)
Fungus 1 (2%)
Granuloma 1 (2%)
Hemorrhage 6 (10%) 4 (7%) 3 (5%) 4 (7%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Macrophage 2 (3%) 2 (3%) 3 (5%)
Infiltration Cellular, Mixed Cell 2 (3%) 3 (5%)
Inflammation, Chronic 4 (7%) 2 (3%)
Alveolar Epithelium, Hyperplasia 8 (13%) 10 (17%) 3 (5%) 3 (5%)
Mediastinum, Cyst 1 (2%)
Mediastinum, Ectopic Tissue 1 (2%)
Nose (60) (60) (60) (60)
Foreign Body 1 (2%)
Fungus 11 (18%) 16 (27%) 15 (25%) 14 (23%)
Inflammation, Suppurative 16 (27%) 18 (30%) 23 (38%) 18 (30%)
Mucosa, Hyperkeratosis 1 (2%)
Mucosa, Metaplasia, Squamous 2 (3%) 1 (2%)
Nasolacrimal Duct, Cyst 1 (2%)
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SPECIAL SENSES SYSTEM
Ear (1) (1) (1) (1)
Inflammation, Suppurative 1 (100%)
Eye (3) (2) (1) (2)
Atrophy 1 (50%)
Cataract 1 (33%) 2 (100%) 1 (100%)
Inflammation, Chronic 1 (33%) 1 (50%)
Cornea, Necrosis 1 (33%) 1 (50%)
Retina, Degeneration 1 (33%) 2 (100%) 1 (100%)
Retrobulbar, Inflammation, Suppurative 1 (50%)
Zymbal's Gland (1) (1) (2)
Dilatation 1 (50%)
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URINARY SYSTEM
Kidney (60) (60) (60) (60)
Cyst 2 (3%) 2 (3%)
Necrosis, Focal 1 (2%)
Nephropathy 59 (98%) 59 (98%) 59 (98%) 60 (100%)
Pigmentation 1 (2%) 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BENZYL ACETATE Date: 09/15/94
Route: DOSED FEED Time: 13:33:56
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0% 0.3% 0.6% 1.2%
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Artery, Inflammation, Chronic 1 (2%)
Pelvis, Dilatation 1 (2%)
Urethra (1) (1)
Bulbourethral Gland, Dilatation 1 (100%) 1 (100%)
Urinary Bladder (60) (60) (60) (60)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
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