TDMS Study 05120-03 Pathology Tables
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
Facility: Southern Research Institute
Chemical CAS #: 140-11-4
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 5| 4| 4| 5| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7|
DAY ON TEST | 0| 5| 2| 6| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 9| 5| 3|
| 8| 7| 0| 0| 4| 6| 1| 1| 1| 1| 6| 1| 1| 1| 1| 1| 1| 8| 7| 1| 1| 1| 6| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 1|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Fatty Change | 2 1 1 1 1 3 1 |
Fibrosis, Focal | 2 |
Focal Cellular Change | 2 2 1 2 2 2 2 2 2 2 2 2 2 3 2 2|
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | 3 2 3 2 3|
Hyperplasia, Multifocal | 2 2 2 2 2|
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Focal | 1 1 2 2 1 1 1 2 1 2 2 2 2 2 2 2 2 1 2|
Necrosis, Focal | |
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 1 1 1 1 1 2 1 2 2 1 1 1|
Biliary Tract, Fibrosis | 1 1 1 1 1 2 2 1 1 1|
Centrilobular, Atrophy | 3 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 1 1 2 2 |
Focal Cellular Change | 1 1 |
Infiltration Cellular, Lipocyte | 2 |
Acinar Cell, Hyperplasia | 1 |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic | 2 |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 5| 4| 4| 5| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7|
DAY ON TEST | 0| 5| 2| 6| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 9| 5| 3|
| 8| 7| 0| 0| 4| 6| 1| 1| 1| 1| 6| 1| 1| 1| 1| 1| 1| 8| 7| 1| 1| 1| 6| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Cyst, Multiple | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Focal Cellular Change | 1 1 2 1|
Vacuolization Cytoplasmic | 4 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | 1 2 |
Pars Distalis, Focal Cellular Change | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 2 1 1 2 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 2 2 3 2 1 3 3 1 3 1 2 3 1 3 3 3 2 2 3|
Hyperplasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Follicle, Cyst | 2 2 |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | |
Hydrometra | |
Inflammation, Suppurative | 1 |
Cervix, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 5| 4| 4| 5| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7|
DAY ON TEST | 0| 5| 2| 6| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 9| 5| 3|
| 8| 7| 0| 0| 4| 6| 1| 1| 1| 1| 6| 1| 1| 1| 1| 1| 1| 8| 7| 1| 1| 1| 6| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Endometrium, Hyperplasia, Cystic | 2 2 1 1 2 2 1 2 2 2 1 3 |
Epithelium, Hyperplasia, Papillary | 3 |
__________________________________________________________________________|
Vagina | |
Angiectasis | |
Cyst | |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Angiectasis | 3 |
Axillary, Hyperplasia | 3 |
Deep Cervical, Hyperplasia | |
Mediastinal, Angiectasis | |
Mediastinal, Pigmentation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | 2 |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 3 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Angiectasis | |
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2|
Fibrosis | 2 |
Hyperplasia | 1 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 2 2 1 2 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 5| 4| 4| 5| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 6| 4| 7|
DAY ON TEST | 0| 5| 2| 6| 3| 5| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 0| 5| 3| 3| 3| 9| 5| 3|
| 8| 7| 0| 0| 4| 6| 1| 1| 1| 1| 6| 1| 1| 1| 1| 1| 1| 8| 7| 1| 1| 1| 6| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Macrophage | 2 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 3 1 2 2 |
Inflammation, Suppurative | 3 1 2 2 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
Inflammation, Chronic | |
Cornea, Necrosis | |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Mineralization | 1 1 2 1 2 |
Nephropathy | 2 1 2 2 1 2 2 2 2 1 1 4 1 3 1 1 2 1 2 2|
Pigmentation | |
Pelvis, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 5| 7| 7| 7| 7| 7| 4| 6| 7| 7| 4| 5| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 5| 3| 3| 5| 8| 3| 2| 3| 2| 2| 5| 9| 0| 3| 5| 2| 5| 2|
| 1| 1| 1| 1| 1| 0| 1| 8| 1| 2| 8| 4| 2| 4| 2| 1| 7| 8| 3| 4| 2| 8| 5| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Fatty Change | 1 2 2 2 1 1 2 1 1 3 2 2 |
Fibrosis, Focal | |
Focal Cellular Change | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | 2 2 2 3 3 2 |
Hyperplasia, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 2|
Infiltration Cellular, Mixed Cell | |
Inflammation, Focal | 2 2 2 2 2 1 2 2 2 2 2 2 2 1 2 1 1 2 2|
Necrosis, Focal | 1 1 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 1 2 2 1 2 2 2 2 2 |
Biliary Tract, Fibrosis | 1 1 1 1 1 1 1 2 2 2 2 |
Centrilobular, Atrophy | 3 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + +|
Fat, Necrosis | 3 3 2|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 1 1 2 1 1 2 2 |
Focal Cellular Change | 1 2 |
Infiltration Cellular, Lipocyte | |
Acinar Cell, Hyperplasia | |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lipocyte | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 5| 7| 7| 7| 7| 7| 4| 6| 7| 7| 4| 5| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 5| 3| 3| 5| 8| 3| 2| 3| 2| 2| 5| 9| 0| 3| 5| 2| 5| 2|
| 1| 1| 1| 1| 1| 0| 1| 8| 1| 2| 8| 4| 2| 4| 2| 1| 7| 8| 3| 4| 2| 8| 5| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Mucosa, Cyst, Multiple | 2 |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Focal Cellular Change | 1 1 1 1 1 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 2 |
Pars Distalis, Focal Cellular Change | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 1 2 2 1 1 1 2 2|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 3 4 3 3 2 1 2 2 2 3 4 3 2 2 3 1 2 2 2 2|
Hyperplasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Follicle, Cyst | 3 4 |
Periovarian Tissue, Cyst | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | 2 |
Hydrometra | 2 2 2 |
Inflammation, Suppurative | 2 1 |
Cervix, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 5| 7| 7| 7| 7| 7| 4| 6| 7| 7| 4| 5| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 5| 3| 3| 5| 8| 3| 2| 3| 2| 2| 5| 9| 0| 3| 5| 2| 5| 2|
| 1| 1| 1| 1| 1| 0| 1| 8| 1| 2| 8| 4| 2| 4| 2| 1| 7| 8| 3| 4| 2| 8| 5| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Endometrium, Hyperplasia, Cystic | 2 2 2 1 2 2 2 3 3 2 1 2 2 1 2 1 |
Epithelium, Hyperplasia, Papillary | 3 2 |
__________________________________________________________________________|
Vagina | + |
Angiectasis | |
Cyst | 3 |
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Axillary, Angiectasis | |
Axillary, Hyperplasia | |
Deep Cervical, Hyperplasia | 3 |
Mediastinal, Angiectasis | |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrosis | 2 2 3 |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 3 2 2 2 3 3 2 2 2 2 2 2 2 2 2 2 2 4|
Fibrosis | |
Hyperplasia | 2 2 2 2 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Inflammation, | |
Suppurative | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 1 1 2 1|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 5| 7| 7| 7| 7| 7| 4| 6| 7| 7| 4| 5| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 5| 3| 3| 5| 8| 3| 2| 3| 2| 2| 5| 9| 0| 3| 5| 2| 5| 2|
| 1| 1| 1| 1| 1| 0| 1| 8| 1| 2| 8| 4| 2| 4| 2| 1| 7| 8| 3| 4| 2| 8| 5| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0% | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 2 3 3 4 2 3 3 2 1 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Macrophage | |
Alveolar Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 1 2 |
Inflammation, Suppurative | 1 1 1 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Atrophy | |
Inflammation, Chronic | 3 |
Cornea, Necrosis | 3 |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Mineralization | 1 2 1 |
Nephropathy | 2 1 3 3 2 2 2 1 1 2 2 2 1 2 2 2 1 1 1 1 3|
Pigmentation | 3 |
Pelvis, Dilatation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 6| 7| 6| | |
DAY ON TEST | 3| 3| 5| 3| 9| 3| 3| 0| 3| 0| | |
| 2| 2| 8| 2| 3| 2| 2| 3| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + + + + + + | 59 |
Parasite Metazoan | | 5 1.4|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 1.0|
Fatty Change | 1 2 3 | 22 1.6|
Fibrosis, Focal | | 1 2.0|
Focal Cellular Change | 2 2 2 2 2 2 2 | 38 2.0|
Hematopoietic Cell Proliferation | | 2 2.0|
Hepatodiaphragmatic Nodule | 3 | 12 2.5|
Hyperplasia, Multifocal | 2 2 2 3 | 21 2.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Focal | 2 1 1 2 2 2 2 | 45 1.7|
Necrosis, Focal | 2 | 3 1.3|
Bile Duct, Hyperplasia | 2 1 2 2 2 2 2 2 | 43 1.4|
Biliary Tract, Fibrosis | 2 1 2 2 2 2 1 1 | 29 1.4|
Centrilobular, Atrophy | 2 | 6 2.3|
__________________________________________________________________________|____________|
Mesentery | + + | 11 |
Fat, Necrosis | 2 1 | 7 2.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy, Focal | 1 2 2 | 16 1.6|
Focal Cellular Change | | 4 1.3|
Infiltration Cellular, Lipocyte | | 1 2.0|
Acinar Cell, Hyperplasia | | 1 1.0|
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Infiltration Cellular, Lipocyte | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
Inflammation, Chronic | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 6| 7| 6| | |
DAY ON TEST | 3| 3| 5| 3| 9| 3| 3| 0| 3| 0| | |
| 2| 2| 8| 2| 3| 2| 2| 3| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Ulcer | | 1 3.0|
Mucosa, Cyst, Multiple | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Focal Cellular Change | 2 | 10 1.2|
Vacuolization Cytoplasmic | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Cyst | | 1 4.0|
Hyperplasia | 2 | 3 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Cyst | 1 3 | 5 1.8|
Pars Distalis, Focal Cellular Change | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | 1 | 1 1.0|
C-Cell, Hyperplasia | 2 2 | 17 1.5|
Follicle, Cyst | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 1 2 3 2 3 3 3 3 | 51 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 6| 7| 6| | |
DAY ON TEST | 3| 3| 5| 3| 9| 3| 3| 0| 3| 0| | |
| 2| 2| 8| 2| 3| 2| 2| 3| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Angiectasis | | 2 2.0|
Follicle, Cyst | 1 4 | 6 2.7|
Periovarian Tissue, Cyst | | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Decidual Reaction | | 1 2.0|
Hydrometra | 2 | 4 2.0|
Inflammation, Suppurative | 2 | 4 1.5|
Cervix, Hyperplasia | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 1 1 2 | 34 1.8|
Epithelium, Hyperplasia, Papillary | | 3 2.7|
__________________________________________________________________________|____________|
Vagina | + | 2 |
Angiectasis | 3 | 1 3.0|
Cyst | | 1 3.0|
Mucosa, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Axillary, Angiectasis | | 1 3.0|
Axillary, Hyperplasia | | 1 3.0|
Deep Cervical, Hyperplasia | | 1 3.0|
Mediastinal, Angiectasis | 2 | 1 2.0|
Mediastinal, Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Angiectasis | 2 | 1 2.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Developmental Malformation | | 1 2.0|
Fibrosis | | 4 2.5|
Hematopoietic Cell Proliferation | 2 | 4 2.8|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 59 |
Angiectasis | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 6| 7| 6| | |
DAY ON TEST | 3| 3| 5| 3| 9| 3| 3| 0| 3| 0| | |
| 2| 2| 8| 2| 3| 2| 2| 3| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cyst | | 4 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | 2 2 3 2 2 2 | 41 2.1|
Fibrosis | | 1 2.0|
Hyperplasia | | 10 1.9|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Inflammation, | | |
Suppurative | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | 2 3 | 12 1.8|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | 3 | 16 2.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 2 | 1 2.0|
Hyperplasia, Macrophage | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 1 1 | 8 1.6|
Inflammation, Suppurative | 1 1 1 | 14 1.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Atrophy | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
Cornea, Necrosis | | 1 3.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 7| 6| 7| 7| 6| 7| 6| | |
DAY ON TEST | 3| 3| 5| 3| 9| 3| 3| 0| 3| 0| | |
| 2| 2| 8| 2| 3| 2| 2| 3| 2| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A |
0% | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | 3 | 1 3.0|
Mineralization | 2 | 9 1.4|
Nephropathy | 1 2 2 2 2 3 1 | 48 1.8|
Pigmentation | | 1 3.0|
Pelvis, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 4| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 6| 6| 4| 4| 7| 7| 4| 5| 7|
DAY ON TEST | 3| 5| 5| 9| 3| 3| 3| 3| 0| 3| 2| 3| 5| 8| 0| 3| 5| 5| 5| 8| 3| 3| 5| 2| 3|
| 5| 6| 5| 6| 3| 5| 5| 5| 7| 5| 1| 5| 6| 4| 1| 5| 4| 4| 7| 7| 5| 5| 7| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 2 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 2 |
Fatty Change | 1 2 1 3 1 1 1 1 1 1 1|
Focal Cellular Change | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 1 1|
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 2 2 2 3 2 3 |
Hyperplasia, Multifocal | 2 2 2 2 2|
Infiltration Cellular, Mixed Cell | 1 |
Inflammation, Focal | 2 1 2 2 1 2 1 3 2 2 2 1 2 2 2 2 1 2 2 2|
Necrosis, Focal | |
Bile Duct, Hyperplasia | 2 2 1 2 2 1 2 1 1 1 3 1 2 2|
Biliary Tract, Fibrosis | 2 1 1 2 1 1 2 1 1 2|
Centrilobular, Atrophy | 2 3 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 1 1 1 1 1 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Focal Cellular Change | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
Incisor, Dysplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Mesenteric Artery, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 4| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 6| 6| 4| 4| 7| 7| 4| 5| 7|
DAY ON TEST | 3| 5| 5| 9| 3| 3| 3| 3| 0| 3| 2| 3| 5| 8| 0| 3| 5| 5| 5| 8| 3| 3| 5| 2| 3|
| 5| 6| 5| 6| 3| 5| 5| 5| 7| 5| 1| 5| 6| 4| 1| 5| 4| 4| 7| 7| 5| 5| 7| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mesenteric Artery, Thrombosis | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Focal Cellular Change | 2 1 1 |
Hyperplasia | 1 |
Inflammation, Focal | |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 |
Cyst | 2 2 |
Hemorrhage | 4 |
Pars Distalis, Focal Cellular Change | 2 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 2 2 3 2 3 1 3 1 1 2 2 3 2 2 2 2 2 2 2 3|
Hyperplasia | |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | |
Necrosis, Focal | |
Follicle, Cyst | |
Periovarian Tissue, Cyst | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hydrometra | 2 |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 4| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 6| 6| 4| 4| 7| 7| 4| 5| 7|
DAY ON TEST | 3| 5| 5| 9| 3| 3| 3| 3| 0| 3| 2| 3| 5| 8| 0| 3| 5| 5| 5| 8| 3| 3| 5| 2| 3|
| 5| 6| 5| 6| 3| 5| 5| 5| 7| 5| 1| 5| 6| 4| 1| 5| 4| 4| 7| 7| 5| 5| 7| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Suppurative | 1 |
Endometrium, Angiectasis | |
Endometrium, Hyperplasia, Cystic | 1 2 1 2 2 2 2 1 2 2 2 2 2 2 2|
Endometrium, Infarct | 2 |
Epithelium, Hyperplasia, Papillary | |
__________________________________________________________________________|
Vagina | +|
Cyst | 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 2 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Hyperplasia | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + I + + M + + M + M + + +|
Cyst | 2 |
Epithelial Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 3 3 2 3 2 2 2 2 2 2 2 2 4 2|
Hyperplasia | 2 3 2 2 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 2 2 2 2 3 2 2 2 2 2|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 1 3 3 2 2 3|
__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 4| 6| 6| 6| 7| 7| 7| 7| 7| 6| 7| 4| 5| 7| 7| 6| 6| 4| 4| 7| 7| 4| 5| 7|
DAY ON TEST | 3| 5| 5| 9| 3| 3| 3| 3| 0| 3| 2| 3| 5| 8| 0| 3| 5| 5| 5| 8| 3| 3| 5| 2| 3|
| 5| 6| 5| 6| 3| 5| 5| 5| 7| 5| 1| 5| 6| 4| 1| 5| 4| 4| 7| 7| 5| 5| 7| 0| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchiectasis | 1 |
Congestion | 3 3 |
Fibrosis, Focal | 1 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Macrophage | 1|
Inflammation, Chronic | 2 |
Pigmentation | |
Alveolar Epithelium, Hyperplasia | 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Hemorrhage | 2 |
Inflammation, Suppurative | 1 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Mineralization | 1 2 2 2 |
Nephropathy | 2 1 2 2 2 2 1 2 1 1 1 2 1 1 2 1 2 1 2 1 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 5| 1| 0| 3| 3| 3| 1| 3| 8| 3| 5| 3| 3| 5| 3| 3| 3| 9| 5| 3| 3| 1| 1| 3| 5|
| 7| 0| 4| 5| 5| 5| 0| 5| 4| 5| 8| 5| 0| 8| 5| 5| 5| 3| 8| 5| 5| 0| 0| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Congestion | |
Fatty Change | 1 2 1 1 3 |
Focal Cellular Change | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Hematopoietic Cell Proliferation | 2 1 |
Hepatodiaphragmatic Nodule | 3 3 2 3 1 |
Hyperplasia, Multifocal | 3 2 2 2 2 2 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Focal | 1 2 2 1 2 1 2 2 2 1 1 1 2 1 2 2 2 1 2 2 2 2 2|
Necrosis, Focal | |
Bile Duct, Hyperplasia | 3 1 1 2 1 2 1 1 1 1 1 1 2 1 2 1|
Biliary Tract, Fibrosis | 3 1 1 1 1 1 2 2 |
Centrilobular, Atrophy | 3 1 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 1 1 2 1 2 1 4 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Focal Cellular Change | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Incisor, Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mesenteric Artery, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 5| 1| 0| 3| 3| 3| 1| 3| 8| 3| 5| 3| 3| 5| 3| 3| 3| 9| 5| 3| 3| 1| 1| 3| 5|
| 7| 0| 4| 5| 5| 5| 0| 5| 4| 5| 8| 5| 0| 8| 5| 5| 5| 3| 8| 5| 5| 0| 0| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Mesenteric Artery, Thrombosis | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Focal Cellular Change | 2 2 1 |
Hyperplasia | |
Inflammation, Focal | 2 |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 |
Cyst | |
Hemorrhage | |
Pars Distalis, Focal Cellular Change | 2 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 3 1 1 |
Follicle, Cyst | 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 2 1 3 3 3 3 3 2 1 2 2 2 3 3 2 2 1 2 3 4 2|
Hyperplasia | |
Inflammation, Chronic | 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Lymphoid | 3 |
Necrosis, Focal | 2 |
Follicle, Cyst | 2 |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hydrometra | 2 2 2|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 5| 1| 0| 3| 3| 3| 1| 3| 8| 3| 5| 3| 3| 5| 3| 3| 3| 9| 5| 3| 3| 1| 1| 3| 5|
| 7| 0| 4| 5| 5| 5| 0| 5| 4| 5| 8| 5| 0| 8| 5| 5| 5| 3| 8| 5| 5| 0| 0| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 1 |
Endometrium, Angiectasis | |
Endometrium, Hyperplasia, Cystic | 2 1 2 1 2 2 1 2 2 1 3 1 2 2 2 2 2|
Endometrium, Infarct | |
Epithelium, Hyperplasia, Papillary | 3 |
__________________________________________________________________________|
Vagina | |
Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 4 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 2 3 |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 1 |
Hematopoietic Cell Proliferation | 3 2 4 2 |
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M + + + + + + +|
Cyst | |
Epithelial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 2 2 3 2 2 2 2 2 2 2 2 2 2 2 |
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 1 3 3 2 3 1 2 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 1 3 2 |
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 7| 4| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 4|
DAY ON TEST | 5| 1| 0| 3| 3| 3| 1| 3| 8| 3| 5| 3| 3| 5| 3| 3| 3| 9| 5| 3| 3| 1| 1| 3| 5|
| 7| 0| 4| 5| 5| 5| 0| 5| 4| 5| 8| 5| 0| 8| 5| 5| 5| 3| 8| 5| 5| 0| 0| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.3% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchiectasis | |
Congestion | |
Fibrosis, Focal | |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Hyperplasia, Macrophage | 1 1 1 1 1 |
Inflammation, Chronic | |
Pigmentation | 1 1 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2|
Hemorrhage | |
Inflammation, Suppurative | 2 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Mineralization | 2 2 1 1 1 1|
Nephropathy | 3 2 1 2 1 1 2 2 1 1 1 1 2 2 2 3 1 1 2 2 1 2 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 2| 3| 3| 5| 3| 3| 3| | |
| 5| 5| 5| 6| 5| 5| 8| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.3% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + M + + | 59 |
Parasite Metazoan | | 6 1.2|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Congestion | | 1 2.0|
Fatty Change | 2 | 17 1.4|
Focal Cellular Change | 2 2 2 2 2 2 2 2 2 | 44 1.9|
Hematopoietic Cell Proliferation | | 2 1.5|
Hepatodiaphragmatic Nodule | 3 | 12 2.4|
Hyperplasia, Multifocal | 2 2 | 16 2.1|
Infiltration Cellular, Mixed Cell | 2 2 2 | 5 1.8|
Inflammation, Focal | 2 2 1 2 2 2 1 2 2 2 | 53 1.7|
Necrosis, Focal | 2 | 1 2.0|
Bile Duct, Hyperplasia | 1 1 2 1 2 2 1 | 37 1.5|
Biliary Tract, Fibrosis | 1 1 2 2 1 | 23 1.4|
Centrilobular, Atrophy | | 4 2.3|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Fat, Necrosis | | 4 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy, Focal | 1 | 20 1.4|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Atrophy, Focal | | 1 2.0|
Focal Cellular Change | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Tooth | | 3 |
Incisor, Dysplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 2| 3| 3| 5| 3| 3| 3| | |
| 5| 5| 5| 6| 5| 5| 8| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.3% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Mesenteric Artery, Inflammation, | | |
Chronic | | 1 3.0|
Mesenteric Artery, Thrombosis | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Focal Cellular Change | | 6 1.5|
Hyperplasia | | 1 1.0|
Inflammation, Focal | | 1 2.0|
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Fibrosis | | 1 2.0|
Hyperplasia | 2 2 | 4 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Angiectasis | 2 | 6 2.3|
Cyst | 3 | 3 2.3|
Hemorrhage | | 1 4.0|
Pars Distalis, Focal Cellular Change | 2 | 3 2.0|
Pars Distalis, Hyperplasia, Focal | | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | 1 1 1 2 | 10 1.4|
Follicle, Cyst | | 1 1.0|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 3 2 2 1 3 2 2 2 3 | 54 2.2|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 2| 3| 3| 5| 3| 3| 3| | |
| 5| 5| 5| 6| 5| 5| 8| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.3% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Inflammation, Chronic | | 2 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Hyperplasia, Histiocytic | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Necrosis, Focal | | 1 2.0|
Follicle, Cyst | | 1 2.0|
Periovarian Tissue, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Cyst | | 1 3.0|
Hydrometra | 1 | 5 1.8|
Inflammation, Suppurative | | 3 1.3|
Endometrium, Angiectasis | 2 | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 1 | 38 1.8|
Endometrium, Infarct | | 1 2.0|
Epithelium, Hyperplasia, Papillary | | 1 3.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia, Histiocytic | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Angiectasis | 2 | 4 2.3|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Angiectasis | | 2 2.0|
Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 3 1.7|
Hematopoietic Cell Proliferation | 2 | 6 2.7|
Hyperplasia, Histiocytic | 2 | 2 2.5|
Hyperplasia, Lymphoid | 2 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M | 54 |
Cyst | | 1 2.0|
Epithelial Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 2| 3| 3| 5| 3| 3| 3| | |
| 5| 5| 5| 6| 5| 5| 8| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.3% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | 2 2 2 4 2 2 | 36 2.3|
Hyperplasia | | 8 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | 3 3 | 21 2.3|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | 3 2 | 13 2.5|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Bronchiectasis | | 1 1.0|
Congestion | | 2 3.0|
Fibrosis, Focal | | 1 1.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Macrophage | | 6 1.0|
Inflammation, Chronic | 1 | 2 1.5|
Pigmentation | | 2 1.0|
Alveolar Epithelium, Hyperplasia | 2 | 3 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 2 2 | 3 2.0|
Hemorrhage | | 1 2.0|
Inflammation, Suppurative | 2 2 1 | 9 1.7|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + + + | 4 |
Cataract | 4 2 4 | 4 3.3|
Retina, Degeneration | 4 4 | 3 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 2| 3| 3| 5| 3| 3| 3| | |
| 5| 5| 5| 6| 5| 5| 8| 5| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.3% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Fibrosis | | 1 2.0|
Mineralization | 2 | 11 1.5|
Nephropathy | 2 3 1 1 2 2 3 2 2 2 | 55 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4|
DAY ON TEST | 3| 3| 2| 5| 0| 3| 3| 6| 3| 3| 3| 5| 3| 0| 9| 1| 3| 3| 3| 3| 2| 3| 2| 3| 5|
| 2| 2| 5| 6| 0| 2| 2| 7| 2| 2| 2| 7| 2| 7| 6| 0| 2| 2| 2| 2| 5| 2| 1| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.6% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Inflammation, Chronic | |
Ulcer | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Degeneration, Cystic | |
Fatty Change | 1 1 2 1 1 1 3 1 1 1 |
Focal Cellular Change | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 3 3 2 3 |
Hyperplasia, Multifocal | 1 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Focal | 2 2 2 1 2 2 1 2 2 2 2 1 2 1 3 2 1 2 2 1 2|
Necrosis, Focal | 1 2 |
Bile Duct, Hyperplasia | 1 1 2 2 1 2 1 1 2 1 4 1 1 1|
Biliary Tract, Fibrosis | 1 2 1 2 1 2 1 4 1 |
Centrilobular, Atrophy | 2 2 4 3 2 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 2 1 3 2 2 2 2 |
Acinar Cell, Hyperplasia | |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Ulcer | 3 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4|
DAY ON TEST | 3| 3| 2| 5| 0| 3| 3| 6| 3| 3| 3| 5| 3| 0| 9| 1| 3| 3| 3| 3| 2| 3| 2| 3| 5|
| 2| 2| 5| 6| 0| 2| 2| 7| 2| 2| 2| 7| 2| 7| 6| 0| 2| 2| 2| 2| 5| 2| 1| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.6% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + |
Incisor, Dysplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mesenteric Artery, Inflammation, | |
Chronic | |
Thoracic, Artery, Aneurysm | |
Thoracic, Artery, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Congestion | 2 2 |
Focal Cellular Change | 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 2 2 2 |
Cyst | 1 1 2 1 2 |
Pars Distalis, Focal Cellular Change | 1 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 1 1 1 1 1|
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 2 2 3 3 2 3 3 2 2 3 3 2 3 3 2 2 3 |
Hyperplasia | |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | 2 |
Follicle, Cyst | 1 2 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4|
DAY ON TEST | 3| 3| 2| 5| 0| 3| 3| 6| 3| 3| 3| 5| 3| 0| 9| 1| 3| 3| 3| 3| 2| 3| 2| 3| 5|
| 2| 2| 5| 6| 0| 2| 2| 7| 2| 2| 2| 7| 2| 7| 6| 0| 2| 2| 2| 2| 5| 2| 1| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.6% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hydrometra | 1 |
Inflammation, Suppurative | 2 |
Endometrium, Hyperplasia, Cystic | 2 1 1 2 1 3 2 2 1 2 2 2 2 1 1 1|
Epithelium, Hyperplasia, Papillary | 3 |
Lumen, Exudate | 3 |
__________________________________________________________________________|
Vagina | + |
Cyst | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 2 |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 3 2 2 2 2 3 2 2 2 2 2 2 |
Fibrosis | 2 |
Hyperplasia | 2 2 2 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2 2 2 2 |
Adventitia, Mandible, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 3 3 |
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 4| 7| 7| 7| 3| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4|
DAY ON TEST | 3| 3| 2| 5| 0| 3| 3| 6| 3| 3| 3| 5| 3| 0| 9| 1| 3| 3| 3| 3| 2| 3| 2| 3| 5|
| 2| 2| 5| 6| 0| 2| 2| 7| 2| 2| 2| 7| 2| 7| 6| 0| 2| 2| 2| 2| 5| 2| 1| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.6% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Macrophage | 1 |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Suppurative | 1 1 1 1 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Hemorrhage | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | |
Dilatation, Focal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Mineralization | 2 1 2|
Nephropathy | 2 1 1 2 1 1 2 2 1 2 2 2 2 1 3 2 2 2 1 2 1 |
Papilla, Necrosis | |
Pelvis, Dilatation | 2 |
Renal Tubule, Dilatation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 4| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 5| 1| 1| 3| 3| 3| 5| 3| 9| 1| 3| 5| 3|
| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 7| 5| 7| 1| 1| 5| 5| 5| 7| 5| 2| 5| 5| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 2|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Inflammation, Chronic | 3 |
Ulcer | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Degeneration, Cystic | 2 |
Fatty Change | 1 1 1 1 1 1 |
Focal Cellular Change | 2 2 2 2 2 2 1 1 2 2 2 2 2 2 2 2 2|
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | 2 |
Hyperplasia, Multifocal | 2 2 1 2 |
Infiltration Cellular, Mixed Cell | 2 2 |
Inflammation, Focal | 1 1 1 2 2 1 1 1 2 2 1 2 1 2 2 1 1 1 1|
Necrosis, Focal | |
Bile Duct, Hyperplasia | 1 2 1 1 1 2 1 2 1 1 1 1 1 1 1 2 1|
Biliary Tract, Fibrosis | 1 1 1 1 2 1 1 1 1 2 1|
Centrilobular, Atrophy | 2 1 2 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | 3 |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 2 1 1 1 1 1 2 2 1 1 1 1 1 1 |
Acinar Cell, Hyperplasia | 3 |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 3 |
Ulcer | 2 3 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 4| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 5| 1| 1| 3| 3| 3| 5| 3| 9| 1| 3| 5| 3|
| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 7| 5| 7| 1| 1| 5| 5| 5| 7| 5| 2| 5| 5| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | |
Incisor, Dysplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Mesenteric Artery, Inflammation, | |
Chronic | 4 |
Thoracic, Artery, Aneurysm | 4 |
Thoracic, Artery, Inflammation, | |
Chronic | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Congestion | 4 |
Focal Cellular Change | 3 1 2 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | 1 2 2 2|
Pars Distalis, Focal Cellular Change | 2 2|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 2 1 |
C-Cell, Hyperplasia | 2 2 1 2 2 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 2 3 2 3 3 3 2 4 2 2 3 2 2 2 2 2 3 2 2 1|
Hyperplasia | 2 |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 4| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 5| 1| 1| 3| 3| 3| 5| 3| 9| 1| 3| 5| 3|
| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 7| 5| 7| 1| 1| 5| 5| 5| 7| 5| 2| 5| 5| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hydrometra | |
Inflammation, Suppurative | 1 1 1 |
Endometrium, Hyperplasia, Cystic | 1 1 1 2 1 2 2 2 2 2 2 2 1 2 3 2 2|
Epithelium, Hyperplasia, Papillary | |
Lumen, Exudate | |
__________________________________________________________________________|
Vagina | + |
Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | |
Hyperplasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Fibrosis | |
Hyperplasia | 1 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 2 3 1 2 2 |
Adventitia, Mandible, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 3 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 4| 7|
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 5| 3| 5| 1| 1| 3| 3| 3| 5| 3| 9| 1| 3| 5| 3|
| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 7| 5| 7| 1| 1| 5| 5| 5| 7| 5| 2| 5| 5| 8| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.6% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Macrophage | |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 3 1 |
Inflammation, Suppurative | 2 2 1 2 1 3 2 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 1 |
Hemorrhage | 3 |
Retina, Degeneration | 4 3 |
__________________________________________________________________________|
Harderian Gland | + |
Dilatation, Focal | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Mineralization | 1 2 2 1 1 |
Nephropathy | 1 1 2 2 2 2 2 1 4 1 1 1 1 3 1 1 1 1|
Papilla, Necrosis | 3 |
Pelvis, Dilatation | |
Renal Tubule, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 2| 3| 5| 3| 3| 3| 3| 5| | |
| 5| 5| 7| 5| 8| 5| 5| 5| 5| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | | 4 1.3|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Dilatation | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 2 2.0|
Degeneration, Cystic | 2 1 | 3 1.7|
Fatty Change | 1 1 | 18 1.2|
Focal Cellular Change | 2 2 2 2 2 3 1 2 | 42 1.9|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | | 5 2.6|
Hyperplasia, Multifocal | 2 | 9 1.8|
Infiltration Cellular, Mixed Cell | | 3 2.0|
Inflammation, Focal | 2 2 1 2 1 2 1 1 1 | 49 1.6|
Necrosis, Focal | | 2 1.5|
Bile Duct, Hyperplasia | 1 1 2 2 2 1 2 | 38 1.4|
Biliary Tract, Fibrosis | 1 1 2 1 1 | 25 1.4|
Centrilobular, Atrophy | 2 | 9 2.2|
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Inflammation, Chronic | | 1 3.0|
Fat, Necrosis | 3 | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy, Focal | 1 1 1 1 1 2 | 29 1.4|
Acinar Cell, Hyperplasia | | 1 3.0|
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 2| 3| 5| 3| 3| 3| 3| 5| | |
| 5| 5| 7| 5| 8| 5| 5| 5| 5| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 3 2.7|
Mucosa, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Incisor, Dysplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Mesenteric Artery, Inflammation, | | |
Chronic | | 1 4.0|
Thoracic, Artery, Aneurysm | | 1 4.0|
Thoracic, Artery, Inflammation, | | |
Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Congestion | | 3 2.7|
Focal Cellular Change | | 7 1.6|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + | 59 |
Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Angiectasis | | 5 2.6|
Cyst | | 9 1.6|
Pars Distalis, Focal Cellular Change | 2 2 2 | 8 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | | 2 1.5|
C-Cell, Hyperplasia | 2 | 14 1.4|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 2| 3| 5| 3| 3| 3| 3| 5| | |
| 5| 5| 7| 5| 8| 5| 5| 5| 5| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 2 3 1 3 2 2 2 | 48 2.3|
Hyperplasia | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Follicle, Cyst | | 2 1.5|
Periovarian Tissue, Cyst | 3 | 1 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Dilatation | | 1 3.0|
Hydrometra | 2 1 | 3 1.3|
Inflammation, Suppurative | | 4 1.3|
Endometrium, Hyperplasia, Cystic | 1 1 2 2 2 1 2 | 40 1.7|
Epithelium, Hyperplasia, Papillary | | 1 3.0|
Lumen, Exudate | | 1 3.0|
__________________________________________________________________________|____________|
Vagina | | 2 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 2 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Depletion Lymphoid | | 1 2.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 3 2.3|
Hematopoietic Cell Proliferation | 2 | 3 2.3|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 59 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | 2 2 2 3 2 | 34 2.1|
Fibrosis | | 1 2.0|
Hyperplasia | 3 | 7 2.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 2| 3| 5| 3| 3| 3| 3| 5| | |
| 5| 5| 7| 5| 8| 5| 5| 5| 5| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Hyperkeratosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | 2 | 12 1.9|
Adventitia, Mandible, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | 3 | 8 2.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | | 2 1.0|
Hyperplasia, Macrophage | | 1 1.0|
Inflammation, Chronic | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 4 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | | 3 2.0|
Inflammation, Suppurative | 1 | 16 1.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Cataract | | 2 2.0|
Hemorrhage | | 1 3.0|
Retina, Degeneration | | 2 3.5|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Dilatation, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 1 2.0|
Mineralization | 2 | 9 1.6|
Nephropathy | 2 1 1 1 2 2 1 2 | 47 1.6|
Papilla, Necrosis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| | |
DAY ON TEST | 3| 3| 2| 3| 5| 3| 3| 3| 3| 5| | |
| 5| 5| 7| 5| 8| 5| 5| 5| 5| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.6% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Pelvis, Dilatation | | 1 2.0|
Renal Tubule, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 4| 7|
DAY ON TEST | 3| 2| 3| 5| 3| 5| 0| 0| 0| 0| 3| 3| 6| 0| 3| 5| 3| 3| 5| 3| 8| 3| 3| 5| 3|
| 2| 6| 2| 8| 2| 6| 7| 7| 4| 7| 2| 2| 9| 7| 2| 6| 2| 2| 6| 2| 2| 2| 2| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + I + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Fatty Change | 3 2 2 1 2 1 3 2 1 |
Fibrosis, Focal | 2 |
Focal Cellular Change | 1 2 1 2 1 2 2 2 3 2 1 2 1 2 2 2 2 2 2 2|
Hepatodiaphragmatic Nodule | 3 3 2|
Hyperplasia, Multifocal | 2 1 1 2 2 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Focal | 2 2 2 2 1 1 1 2 2 2 1 1 1 2 1 2 2 1 1 2 1|
Necrosis, Focal | |
Pigmentation | 1 |
Bile Duct, Hyperplasia | 1 1 1 1 1 2 2 1 1 2 1 1 1 1 1 1|
Biliary Tract, Fibrosis | 1 2 1 1 1 2 |
Centrilobular, Atrophy | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 2 2 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 1 2 1 3 1 1 1|
Focal Cellular Change | 1 |
Acinar Cell, Hyperplasia | 3 |
Duct, Dilatation | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | |
Inflammation, Chronic | |
Ulcer | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Erosion | 2 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 4| 7|
DAY ON TEST | 3| 2| 3| 5| 3| 5| 0| 0| 0| 0| 3| 3| 6| 0| 3| 5| 3| 3| 5| 3| 8| 3| 3| 5| 3|
| 2| 6| 2| 8| 2| 6| 7| 7| 4| 7| 2| 2| 9| 7| 2| 6| 2| 2| 6| 2| 2| 2| 2| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Congestion | |
Focal Cellular Change | 1 |
Hyperplasia | 2 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 3 2 2 1|
Pars Distalis, Focal Cellular Change | 2 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 1 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 1 3 2 1 2 3 1 1 2 2 2 1 2 4 1 2 1 2 3 2 2|
Hyperplasia | 1 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + I + +|
Follicle, Cyst | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | 2 |
Decidual Reaction | |
Hemorrhage | |
Hydrometra | 2 2 |
Inflammation, Suppurative | 1 1 |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 4| 7|
DAY ON TEST | 3| 2| 3| 5| 3| 5| 0| 0| 0| 0| 3| 3| 6| 0| 3| 5| 3| 3| 5| 3| 8| 3| 3| 5| 3|
| 2| 6| 2| 8| 2| 6| 7| 7| 4| 7| 2| 2| 9| 7| 2| 6| 2| 2| 6| 2| 2| 2| 2| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Prolapse | |
Endometrium, Hyperplasia, Cystic | 2 1 2 1 2 2 1 1 2 2 2 1 1 2 3 1 2|
Endometrium, Infarct | |
Epithelium, Hyperplasia, Papillary | 3 |
__________________________________________________________________________|
Vagina | + |
Cyst | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 2 2 |
Pancreatic, Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 3 2 3 2|
Necrosis, Focal | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 4 2 1 2 3 2 3 2 2 2 2 2 2 |
Hyperplasia | 2 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 1 2 3 3 4 1 1 3 3 2 3 3 1 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 2 3 4 4 2 |
Hemorrhage | |
__________________________________________________________________________|
Peripheral Nerve | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 5| 7| 7| 4| 7|
DAY ON TEST | 3| 2| 3| 5| 3| 5| 0| 0| 0| 0| 3| 3| 6| 0| 3| 5| 3| 3| 5| 3| 8| 3| 3| 5| 3|
| 2| 6| 2| 8| 2| 6| 7| 7| 4| 7| 2| 2| 9| 7| 2| 6| 2| 2| 6| 2| 2| 2| 2| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | |
Fibrosis, Focal | 2 |
Granuloma | 2 |
Hemorrhage | 2 |
Hyperplasia, Macrophage | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 2 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Inflammation, Focal | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 2 2 2 |
Necrosis, Focal | |
Nephropathy | 2 1 1 2 2 2 1 2 1 2 2 1 2 2 2 2 2 2|
Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 6| 5| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 7| 7| 7| 6|
DAY ON TEST | 6| 9| 3| 3| 3| 1| 5| 5| 6| 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 7| 5| 3| 3| 3| 9|
| 8| 3| 1| 2| 2| 5| 6| 3| 8| 2| 0| 6| 2| 2| 2| 2| 6| 2| 2| 2| 7| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 2 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fatty Change | 3 3 2 3 3 1 2 1 3 2 3 |
Fibrosis, Focal | |
Focal Cellular Change | 1 2 2 2 2 2 1 2 2 2 2 1 1 2 2 3 2 2|
Hepatodiaphragmatic Nodule | 2 2 2 |
Hyperplasia, Multifocal | 2 2 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Focal | 2 2 2 2 1 1 2 2 1 2 2 2 2 2 2 1|
Necrosis, Focal | 1 |
Pigmentation | |
Bile Duct, Hyperplasia | 3 3 2 2 1 2 1 2 2 2 2 1 1 1 2 2 2|
Biliary Tract, Fibrosis | 2 2 2 2 2 2 1 2 1 2 |
Centrilobular, Atrophy | 3 1 3 3 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 1 1 2 1 1 2 |
Focal Cellular Change | |
Acinar Cell, Hyperplasia | |
Duct, Dilatation | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 3 |
Erosion | 1 |
Inflammation, Chronic | 3 2 2 |
Ulcer | 2 |
Mucosa, Hyperplasia | 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | 1 |
Erosion | 1 2 |
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 6| 5| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 7| 7| 7| 6|
DAY ON TEST | 6| 9| 3| 3| 3| 1| 5| 5| 6| 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 7| 5| 3| 3| 3| 9|
| 8| 3| 1| 2| 2| 5| 6| 3| 8| 2| 0| 6| 2| 2| 2| 2| 6| 2| 2| 2| 7| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Congestion | 2 |
Focal Cellular Change | 1 1 |
Hyperplasia | |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 |
Cyst | 2 1 2 2 2|
Pars Distalis, Focal Cellular Change | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Ultimobranchial Cyst | 2 |
C-Cell, Hyperplasia | 1 1 2 2 1 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 1 3 2 3 2 3 2 2 2 2 2 2 1 2 1|
Hyperplasia | |
Inflammation, Chronic | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Cyst | 3 4 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenomyosis | |
Decidual Reaction | X |
Hemorrhage | 4 |
Hydrometra | 1 2 |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 6| 5| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 7| 7| 7| 6|
DAY ON TEST | 6| 9| 3| 3| 3| 1| 5| 5| 6| 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 7| 5| 3| 3| 3| 9|
| 8| 3| 1| 2| 2| 5| 6| 3| 8| 2| 0| 6| 2| 2| 2| 2| 6| 2| 2| 2| 7| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Prolapse | 3 |
Endometrium, Hyperplasia, Cystic | 2 2 1 1 2 2 2 1 1 2 2 2 2 2 1 1 1 1 2 1 1|
Endometrium, Infarct | 2 |
Epithelium, Hyperplasia, Papillary | |
__________________________________________________________________________|
Vagina | + |
Cyst | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | |
Pancreatic, Angiectasis | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +|
Angiectasis | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + I + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 1 2 |
Hematopoietic Cell Proliferation | 2 |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 2 3 2 4 2 2 2 2 2 2 2|
Hyperplasia | 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 4 2 2 1 2 3 2|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 4 1 |
Hemorrhage | 3 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 6| 5| 6| 7| 7| 7| 4| 5| 6| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 4| 7| 7| 7| 6|
DAY ON TEST | 6| 9| 3| 3| 3| 1| 5| 5| 6| 3| 0| 5| 3| 3| 3| 3| 5| 3| 3| 7| 5| 3| 3| 3| 9|
| 8| 3| 1| 2| 2| 5| 6| 3| 8| 2| 0| 6| 2| 2| 2| 2| 6| 2| 2| 2| 7| 2| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 2 |
Fibrosis, Focal | |
Granuloma | |
Hemorrhage | 2 |
Hyperplasia, Macrophage | 1 |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 1 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Inflammation, Focal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 2 1 2 |
Necrosis, Focal | |
Nephropathy | 2 2 1 1 1 1 1 2 1 2 1 2 1 2 1 1 1 |
Pigmentation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 4| 7| 7| 7| 7| 4| 6| | |
DAY ON TEST | 0| 6| 6| 5| 3| 3| 3| 3| 5| 4| | |
| 8| 7| 8| 7| 2| 2| 2| 2| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.2% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | | 4 1.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Parasite Metazoan | 2 1 | 3 1.3|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Cyst | | 1 3.0|
Fatty Change | 2 3 | 22 2.2|
Fibrosis, Focal | | 1 2.0|
Focal Cellular Change | 2 2 2 2 2 2 2 | 45 1.8|
Hepatodiaphragmatic Nodule | 3 | 7 2.4|
Hyperplasia, Multifocal | 2 2 1 | 13 1.8|
Infiltration Cellular, Mixed Cell | 2 | 2 2.0|
Inflammation, Focal | 1 2 1 2 2 2 2 | 44 1.6|
Necrosis, Focal | | 1 1.0|
Pigmentation | | 1 1.0|
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 1 | 41 1.4|
Biliary Tract, Fibrosis | 1 2 1 | 19 1.6|
Centrilobular, Atrophy | 3 | 7 2.4|
__________________________________________________________________________|____________|
Mesentery | | 12 |
Fat, Necrosis | | 7 2.1|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy, Focal | 1 2 | 19 1.3|
Focal Cellular Change | | 1 1.0|
Acinar Cell, Hyperplasia | | 1 3.0|
Duct, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Atrophy, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | | 2 2.5|
Erosion | | 1 1.0|
Inflammation, Chronic | | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 4| 7| 7| 7| 7| 4| 6| | |
DAY ON TEST | 0| 6| 6| 5| 3| 3| 3| 3| 5| 4| | |
| 8| 7| 8| 7| 2| 2| 2| 2| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.2% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | | 1 2.0|
Mucosa, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Developmental Malformation | | 1 1.0|
Erosion | | 3 1.7|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 2 1.5|
Congestion | | 1 2.0|
Focal Cellular Change | 1 1 | 5 1.0|
Hyperplasia | | 1 2.0|
Vacuolization Cytoplasmic | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | | 5 1.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + + + + + + | 57 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Angiectasis | | 4 1.8|
Cyst | 1 | 10 1.8|
Pars Distalis, Focal Cellular Change | 2 | 3 2.0|
Pars Distalis, Hyperplasia, Focal | | 3 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Ultimobranchial Cyst | | 1 2.0|
C-Cell, Hyperplasia | 2 2 | 10 1.4|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
Degeneration, Cystic | 1 2 3 2 1 3 3 3 | 47 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 4| 7| 7| 7| 7| 4| 6| | |
DAY ON TEST | 0| 6| 6| 5| 3| 3| 3| 3| 5| 4| | |
| 8| 7| 8| 7| 2| 2| 2| 2| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.2% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | 1 2 | 4 1.5|
Inflammation, Chronic | | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Follicle, Cyst | 3 | 4 2.8|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Adenomyosis | | 1 2.0|
Decidual Reaction | | 1 |
Hemorrhage | | 1 4.0|
Hydrometra | | 4 1.8|
Inflammation, Suppurative | | 2 1.0|
Prolapse | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 1 2 2 2 1 | 43 1.6|
Endometrium, Infarct | | 1 2.0|
Epithelium, Hyperplasia, Papillary | | 1 3.0|
__________________________________________________________________________|____________|
Vagina | | 2 |
Cyst | | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Angiectasis | | 2 2.0|
Pancreatic, Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Angiectasis | 2 | 3 1.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Angiectasis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | 2 1 | 6 1.7|
Hematopoietic Cell Proliferation | | 5 2.4|
Necrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 60 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | 2 3 3 2 2 1 3 | 35 2.2|
Hyperplasia | | 6 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 4| 7| 7| 7| 7| 4| 6| | |
DAY ON TEST | 0| 6| 6| 5| 3| 3| 3| 3| 5| 4| | |
| 8| 7| 8| 7| 2| 2| 2| 2| 7| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.2% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperkeratosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | | 22 2.3|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | 4 4 3 | 12 3.1|
Hemorrhage | | 2 2.5|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Fibrosis, Focal | | 1 2.0|
Granuloma | | 1 2.0|
Hemorrhage | | 2 2.0|
Hyperplasia, Macrophage | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 1 1 | 13 1.1|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Inflammation, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Mineralization | 1 2 | 10 1.7|
Necrosis, Focal | 2 | 1 2.0|
Nephropathy | 2 2 1 1 1 1 2 2 1 | 44 1.5|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 7| 4| 7| 6| 5| 7| 7| 6| 4| 7| 6| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 2| 1| 5| 0| 2| 1| 2| 5| 2| 8| 2| 0| 6| 2| 2| 4| 5| 2| 3| 0| 5| 6| 2|
| 9| 9| 9| 0| 4| 0| 9| 4| 5| 6| 5| 7| 9| 0| 0| 9| 9| 3| 6| 9| 3| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Degeneration, Cystic | 3 2 2 2 2 1 1 1 2 2|
Fatty Change | 1 1 2 2 2 2 1 1 1 2 2 2 1 2 2 1 2 |
Focal Cellular Change | 2 2 2 2 2 2 1 1 1 2 1|
Hemorrhage | |
Hepatodiaphragmatic Nodule | 2 3 2 2 |
Hyperplasia, Multifocal | 2 2 2 3 2 2 2 2 3 |
Infiltration Cellular, Mixed Cell | 2 1 2 |
Inflammation, Focal | 2 2 2 2 2 1 2 1 2 2 2 2 2 2 2 1 3 2|
Necrosis, Focal | |
Thrombosis | 2 |
Bile Duct, Hyperplasia | 2 2 2 3 3 3 2 3 2 2 2 1 2 2 2 2 2 2 3 2 1 3 2|
Biliary Tract, Fibrosis | 2 2 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 1 1 3 2|
Centrilobular, Atrophy | 2 2 2 2 3 3 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + +|
Inflammation, Chronic | |
Fat, Necrosis | 2 3 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 2 1 2 2 1 1 1 2 1 1 2 1|
Focal Cellular Change | 1 1 2 |
Acinar Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
Ulcer | 4 |
Mucosa, Hyperplasia | 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | 2 1 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 7| 4| 7| 6| 5| 7| 7| 6| 4| 7| 6| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 2| 1| 5| 0| 2| 1| 2| 5| 2| 8| 2| 0| 6| 2| 2| 4| 5| 2| 3| 0| 5| 6| 2|
| 9| 9| 9| 0| 4| 0| 9| 4| 5| 6| 5| 7| 9| 0| 0| 9| 9| 3| 6| 9| 3| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 1 |
Pigmentation | 2 |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Incisor, Dysplasia | |
Incisor, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + |
Mesenteric Artery, Inflammation, | |
Chronic | 3 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Focal Cellular Change | 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 2 1 2 2 1 2 2 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 3 2 |
Pars Distalis, Focal Cellular Change | 1 2 2|
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Pigmentation | 2 |
C-Cell, Hyperplasia | 2 1 |
Follicle, Cyst | 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 3 3 1 1 3 2 3 1 3 3 3 1 3 2 2 3 3 2 2 4|
Hyperplasia | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 7| 4| 7| 6| 5| 7| 7| 6| 4| 7| 6| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 2| 1| 5| 0| 2| 1| 2| 5| 2| 8| 2| 0| 6| 2| 2| 4| 5| 2| 3| 0| 5| 6| 2|
| 9| 9| 9| 0| 4| 0| 9| 4| 5| 6| 5| 7| 9| 0| 0| 9| 9| 3| 6| 9| 3| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hyperplasia | |
Inflammation, Suppurative | 2 2 1 2 2 4 2 1 3 1 2 3 2 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 4 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypocellularity | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Mediastinal, Angiectasis | 3 |
Pancreatic, Angiectasis | 2 |
Pancreatic, Cyst | 3|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
Edema | |
Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Hyperplasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 |
Hematopoietic Cell Proliferation | 2 2 |
Hemorrhage | |
Hyperplasia, Histiocytic | 3 |
Necrosis, Focal | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 3 2 |
Hemorrhage | |
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | |
Hyperkeratosis, Focal | 4 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 7| 4| 7| 6| 5| 7| 7| 6| 4| 7| 6| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 2| 1| 5| 0| 2| 1| 2| 5| 2| 8| 2| 0| 6| 2| 2| 4| 5| 2| 3| 0| 5| 6| 2|
| 9| 9| 9| 0| 4| 0| 9| 4| 5| 6| 5| 7| 9| 0| 0| 9| 9| 3| 6| 9| 3| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | |
Inflammation, Chronic | 2 |
Ulcer | 2 |
Epidermis, Hyperplasia | 2 |
Subcutaneous Tissue, Fat, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Hemorrhage | 2 |
Hydrocephalus | 2 3 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 2 1 1 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Mixed Cell | 2 2 |
Alveolar Epithelium, Hyperplasia | 2 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 1 |
Inflammation, Suppurative | 2 2 1 3 3 |
Mucosa, Hyperkeratosis | 3 |
Mucosa, Metaplasia, Squamous | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cataract | |
Inflammation, Chronic | 4 |
Cornea, Necrosis | 4 |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 7| 4| 7| 6| 5| 7| 7| 6| 4| 7| 6| 7| 4| 6| 7|
DAY ON TEST | 2| 2| 2| 1| 5| 0| 2| 1| 2| 5| 2| 8| 2| 0| 6| 2| 2| 4| 5| 2| 3| 0| 5| 6| 2|
| 9| 9| 9| 0| 4| 0| 9| 4| 5| 6| 5| 7| 9| 0| 0| 9| 9| 3| 6| 9| 3| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0% | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Focal | 2 |
Nephropathy | 2 2 2 3 2 2 2 2 2 1 2 1 3 2 2 3 2 3 1 2 1 2 2 3 2|
Pigmentation | |
__________________________________________________________________________|
Urethra | |
Bulbourethral Gland, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 4| 6| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 4| 4| 7| 4| 7| 4| 7| 6|
DAY ON TEST | 2| 5| 3| 5| 2| 2| 0| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 5| 6| 2| 5| 2| 9| 2| 8|
| 5| 7| 1| 7| 9| 9| 5| 9| 9| 8| 9| 5| 9| 4| 9| 9| 9| 8| 7| 9| 8| 9| 5| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 2 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 2 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Degeneration, Cystic | 2 1 2 2 2 |
Fatty Change | 1 4 1 1 1 2 1 1 2 1 1 2 2|
Focal Cellular Change | 2 1 2 2 1 1 2 2 1 2 2 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | 3 2 2 2 |
Hyperplasia, Multifocal | 2 2 2 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 2 |
Inflammation, Focal | 2 1 1 2 2 1 1 1 1 1 1 1 2 1 2 2 1 2 2 |
Necrosis, Focal | 1|
Thrombosis | |
Bile Duct, Hyperplasia | 2 1 3 1 2 3 3 3 2 2 2 1 2 3 2 3 2 2 2 2 2 2 2|
Biliary Tract, Fibrosis | 2 1 2 1 2 2 2 2 1 1 1 1 2 2 2 2 2 1 2 2 2 2|
Centrilobular, Atrophy | 4 2 2 1 2|
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + + + +|
Inflammation, Chronic | |
Fat, Necrosis | 2 2 2 2 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 3 2 1 1 2 1 1 1 1 1|
Focal Cellular Change | 1 |
Acinar Cell, Hyperplasia | 2 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Ulcer | |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | 2 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 4| 6| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 4| 4| 7| 4| 7| 4| 7| 6|
DAY ON TEST | 2| 5| 3| 5| 2| 2| 0| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 5| 6| 2| 5| 2| 9| 2| 8|
| 5| 7| 1| 7| 9| 9| 5| 9| 9| 8| 9| 5| 9| 4| 9| 9| 9| 8| 7| 9| 8| 9| 5| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | |
Pigmentation | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + +|
Incisor, Dysplasia | 2 |
Incisor, Inflammation, Suppurative | 3 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Mesenteric Artery, Inflammation, | |
Chronic | 3 1 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Focal Cellular Change | 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 2 |
Pars Distalis, Focal Cellular Change | 1 2 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Pigmentation | |
C-Cell, Hyperplasia | 2 |
Follicle, Cyst | 2 2 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 1 3 3 1 3 2|
Hyperplasia | 2 |
Inflammation, Chronic | 4 |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 4| 6| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 4| 4| 7| 4| 7| 4| 7| 6|
DAY ON TEST | 2| 5| 3| 5| 2| 2| 0| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 5| 6| 2| 5| 2| 9| 2| 8|
| 5| 7| 1| 7| 9| 9| 5| 9| 9| 8| 9| 5| 9| 4| 9| 9| 9| 8| 7| 9| 8| 9| 5| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hyperplasia | 2 |
Inflammation, Suppurative | 1 2 2 2 1 1 2 1 1 3 1 1 2 1 2 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 4 4 3 3 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypocellularity | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Mediastinal, Angiectasis | 2 2 |
Pancreatic, Angiectasis | |
Pancreatic, Cyst | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | 3 |
Edema | 3 |
Hyperplasia | 2 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 3 2 2 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Hyperplasia, Histiocytic | |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + M|
Dilatation | 3 3 1 2 |
Hemorrhage | |
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | |
Hyperkeratosis, Focal | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 4| 6| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 4| 4| 7| 4| 7| 4| 7| 6|
DAY ON TEST | 2| 5| 3| 5| 2| 2| 0| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 5| 6| 2| 5| 2| 9| 2| 8|
| 5| 7| 1| 7| 9| 9| 5| 9| 9| 8| 9| 5| 9| 4| 9| 9| 9| 8| 7| 9| 8| 9| 5| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation, Chronic | |
Ulcer | |
Epidermis, Hyperplasia | |
Subcutaneous Tissue, Fat, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 2|
Hemorrhage | 3|
Hydrocephalus | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 2 2 2|
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Mixed Cell | |
Alveolar Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 2 2 2 2 2 |
Inflammation, Suppurative | 1 2 1 2 2 2 2 2 2 |
Mucosa, Hyperkeratosis | |
Mucosa, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Inflammation, Chronic | |
Cornea, Necrosis | |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 4| 6| 4| 7| 7| 7| 7| 7| 4| 7| 5| 7| 7| 7| 7| 7| 4| 4| 7| 4| 7| 4| 7| 6|
DAY ON TEST | 2| 5| 3| 5| 2| 2| 0| 2| 2| 5| 2| 2| 2| 2| 2| 2| 2| 5| 6| 2| 5| 2| 9| 2| 8|
| 5| 7| 1| 7| 9| 9| 5| 9| 9| 8| 9| 5| 9| 4| 9| 9| 9| 8| 7| 9| 8| 9| 5| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0% | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Focal | |
Nephropathy | 2 2 3 1 3 2 3 1 2 1 1 2 2 2 3 2 3 2 1 2 1 3 3 2 2|
Pigmentation | 2 |
__________________________________________________________________________|
Urethra | + |
Bulbourethral Gland, Dilatation | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 4| 7| 4| 7| 7| 5| 7| | |
DAY ON TEST | 2| 4| 2| 5| 2| 5| 2| 2| 7| 2| | |
| 9| 2| 9| 8| 9| 8| 9| 9| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | | 4 1.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + + + + + + | 59 |
Parasite Metazoan | 1 | 5 1.2|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 2 | 4 2.0|
Degeneration, Cystic | 2 1 | 17 1.8|
Fatty Change | 2 3 1 1 2 1 | 36 1.6|
Focal Cellular Change | 2 3 1 2 1 | 27 1.7|
Hemorrhage | 3 | 1 3.0|
Hepatodiaphragmatic Nodule | 3 | 9 2.3|
Hyperplasia, Multifocal | 2 | 16 2.1|
Infiltration Cellular, Mixed Cell | 2 2 | 7 1.9|
Inflammation, Focal | 2 1 2 1 2 2 2 | 44 1.7|
Necrosis, Focal | | 1 1.0|
Thrombosis | | 1 2.0|
Bile Duct, Hyperplasia | 3 2 2 2 2 2 2 3 2 2 | 56 2.2|
Biliary Tract, Fibrosis | 2 2 1 1 1 2 2 2 1 | 54 1.7|
Centrilobular, Atrophy | 2 4 | 13 2.4|
Centrilobular, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + + + + + | 17 |
Inflammation, Chronic | 2 | 1 2.0|
Fat, Necrosis | 3 3 3 | 12 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy, Focal | 1 1 2 2 1 3 | 32 1.4|
Focal Cellular Change | 1 1 | 6 1.2|
Acinar Cell, Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 1 4.0|
Ulcer | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 4| 7| 4| 7| 7| 5| 7| | |
DAY ON TEST | 2| 4| 2| 5| 2| 5| 2| 2| 7| 2| | |
| 9| 2| 9| 8| 9| 8| 9| 9| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mucosa, Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Edema | | 2 2.0|
Erosion | | 3 1.7|
Hyperplasia, Lymphoid | 2 | 3 2.0|
Inflammation, Chronic | | 1 1.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Tooth | | 2 |
Incisor, Dysplasia | | 1 2.0|
Incisor, Inflammation, Suppurative | | 2 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | | 3 |
Mesenteric Artery, Inflammation, | | |
Chronic | | 3 2.3|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Focal Cellular Change | 2 1 | 9 1.2|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Hyperplasia | 1 1 | 12 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Angiectasis | 2 1 | 2 1.5|
Cyst | | 3 2.3|
Pars Distalis, Focal Cellular Change | | 5 1.6|
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | | 1 2.0|
Pigmentation | | 1 2.0|
C-Cell, Hyperplasia | 1 | 4 1.5|
Follicle, Cyst | | 3 1.7|
Follicular Cell, Hyperplasia | | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 4| 7| 4| 7| 7| 5| 7| | |
DAY ON TEST | 2| 4| 2| 5| 2| 5| 2| 2| 7| 2| | |
| 9| 2| 9| 8| 9| 8| 9| 9| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 3 3 3 2 3 2 3 3 3 2 | 54 2.5|
Hyperplasia | | 1 2.0|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Dilatation | | 2 3.0|
Hyperplasia | | 1 2.0|
Inflammation, Suppurative | 1 1 1 1 3 1 2 | 37 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | | 3 2.7|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Germinal Epithelium, Degeneration | | 10 3.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypocellularity | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Cyst | | 1 3.0|
Mediastinal, Angiectasis | 2 | 4 2.3|
Pancreatic, Angiectasis | | 1 2.0|
Pancreatic, Cyst | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Angiectasis | 2 | 2 2.5|
Cyst | | 1 3.0|
Edema | | 1 3.0|
Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Cyst | | 1 4.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | 2 3 2 2 | 10 2.3|
Hematopoietic Cell Proliferation | | 3 2.0|
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 4| 7| 4| 7| 7| 5| 7| | |
DAY ON TEST | 2| 4| 2| 5| 2| 5| 2| 2| 7| 2| | |
| 9| 2| 9| 8| 9| 8| 9| 9| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Histiocytic | | 1 3.0|
Necrosis, Focal | 3 | 2 2.5|
__________________________________________________________________________|____________|
Thymus | M I + + + + + + + + | 58 |
Cyst | | 3 1.7|
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 58 |
Dilatation | | 7 2.1|
Hemorrhage | 2 | 1 2.0|
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Edema | 3 | 1 3.0|
Hemorrhage | 3 | 1 3.0|
Hyperkeratosis, Focal | | 1 4.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation, Chronic | 3 | 2 2.5|
Ulcer | 3 | 2 2.5|
Epidermis, Hyperplasia | | 1 2.0|
Subcutaneous Tissue, Fat, Necrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 3 2.7|
Hemorrhage | | 2 2.5|
Hydrocephalus | | 2 2.5|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Hemorrhage | | 6 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 4| 7| 4| 7| 7| 5| 7| | |
DAY ON TEST | 2| 4| 2| 5| 2| 5| 2| 2| 7| 2| | |
| 9| 2| 9| 8| 9| 8| 9| 9| 4| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0% | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Mixed Cell | | 2 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 8 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 2 | 11 1.9|
Inflammation, Suppurative | 2 2 | 16 1.9|
Mucosa, Hyperkeratosis | | 1 3.0|
Mucosa, Metaplasia, Squamous | | 2 2.5|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | | 1 3.0|
Inflammation, Chronic | | 1 4.0|
Cornea, Necrosis | | 1 4.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Necrosis, Focal | | 1 2.0|
Nephropathy | 2 3 1 3 2 2 2 2 2 | 59 2.1|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Bulbourethral Gland, Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 5| 4| 6| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 3| 7| 7| 4|
DAY ON TEST | 2| 5| 3| 3| 3| 5| 5| 9| 3| 3| 3| 3| 5| 3| 7| 3| 3| 1| 3| 5| 3| 9| 3| 3| 5|
| 8| 6| 0| 0| 0| 3| 6| 3| 0| 3| 1| 1| 7| 1| 0| 1| 1| 0| 1| 7| 1| 6| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.3% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | |
Degeneration, Cystic | 2 1 2 2 1 1 1 2 3 2 |
Fatty Change | 1 2 1 2 1 1 1 2 1 1 2 1 1 1 1 2 2 |
Fibrosis, Focal | 2 |
Focal Cellular Change | 1 1 2 2 2 2 1 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 3 |
Hepatodiaphragmatic Nodule | 3 3 3 |
Hyperplasia, Multifocal | 2 2 2 2 2 1 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Focal | 2 2 2 1 1 2 2 2 1 2 2 2 1 2 2|
Necrosis, Focal | |
Pigmentation | 2 |
Bile Duct, Hyperplasia | 2 1 2 3 2 1 2 4 2 3 2 2 2 2 2 2 2 3 3 2 3 2 3 2 2|
Biliary Tract, Fibrosis | 1 2 3 2 1 2 2 2 2 1 2 2 2 1 2 2 2 1 2 2 3 2 1|
Centrilobular, Atrophy | 2 1 3 2 3 3 2 |
Centrilobular, Necrosis | 3 2 |
__________________________________________________________________________|
Mesentery | + + + + + +|
Inflammation, Chronic | |
Fat, Necrosis | 3 2 3|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 1 2 1 2 1 2 2 2 1 1|
Acinar Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | |
Hyperplasia | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 5| 4| 6| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 3| 7| 7| 4|
DAY ON TEST | 2| 5| 3| 3| 3| 5| 5| 9| 3| 3| 3| 3| 5| 3| 7| 3| 3| 1| 3| 5| 3| 9| 3| 3| 5|
| 8| 6| 0| 0| 0| 3| 6| 3| 0| 3| 1| 1| 7| 1| 0| 1| 1| 0| 1| 7| 1| 6| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.3% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Edema | 2 |
Erosion | 1 |
Inflammation, Chronic | 1 1 3 |
Ulcer | 3 |
Mucosa, Hyperplasia | 2 1 1 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | |
Inflammation, Chronic | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + |
Mesenteric Artery, Inflammation, | |
Chronic | 2 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 3 |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Focal Cellular Change | 1 2 |
Hematopoietic Cell Proliferation | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + M + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | 2 2 1 |
Hemorrhage | |
Pars Distalis, Focal Cellular Change | 1 |
Pars Distalis, Hyperplasia, Focal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 2 2 |
Follicle, Cyst | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 5| 4| 6| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 3| 7| 7| 4|
DAY ON TEST | 2| 5| 3| 3| 3| 5| 5| 9| 3| 3| 3| 3| 5| 3| 7| 3| 3| 1| 3| 5| 3| 9| 3| 3| 5|
| 8| 6| 0| 0| 0| 3| 6| 3| 0| 3| 1| 1| 7| 1| 0| 1| 1| 0| 1| 7| 1| 6| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.3% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 2 3 2 2 2 2 3 3 4 2 2 3 2 3 3 2 4 3 3 2 3 3 2|
Hyperplasia | 2 2 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Hyperplasia | 1 1 1|
Inflammation, Suppurative | 1 2 2 1 1 1 2 2 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 3 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | 2 3 2 1 2 3 3 |
Hematopoietic Cell Proliferation | 3 |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 4 1 |
Hemorrhage | 3 |
Hyperplasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 5| 4| 6| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 3| 7| 7| 4|
DAY ON TEST | 2| 5| 3| 3| 3| 5| 5| 9| 3| 3| 3| 3| 5| 3| 7| 3| 3| 1| 3| 5| 3| 9| 3| 3| 5|
| 8| 6| 0| 0| 0| 3| 6| 3| 0| 3| 1| 1| 7| 1| 0| 1| 1| 0| 1| 7| 1| 6| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.3% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Exudate | 1 |
Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Hemorrhage | 2 |
Meninges, Angiectasis | 1 |
Meninges, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | 2 |
Fibrosis, Focal | |
Fungus | |
Hemorrhage | 1 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Macrophage | 2 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | 1 2 2 2 |
Mediastinum, Ectopic Tissue | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 2 2 2 2 2 |
Inflammation, Suppurative | 3 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Atrophy | |
Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Nephropathy | 2 2 2 2 2 2 1 2 2 2 2 3 2 2 2 2 2 2 2 1 2 2 3 2 1|
Pigmentation | 3 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 5| 4| 7| 7| 7| 5| 4| 6| 7| 6| 7| 7| 4| 7| 5| 7| 7| 7| 7| 4| 7| 3| 7| 7| 4|
DAY ON TEST | 2| 5| 3| 3| 3| 5| 5| 9| 3| 3| 3| 3| 5| 3| 7| 3| 3| 1| 3| 5| 3| 9| 3| 3| 5|
| 8| 6| 0| 0| 0| 3| 6| 3| 0| 3| 1| 1| 7| 1| 0| 1| 1| 0| 1| 7| 1| 6| 1| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.3% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Artery, Inflammation, Chronic | |
Pelvis, Dilatation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 4| 7| 6| 7| 5| 7| 6| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 5| 8| 3| 3| 5| 3| 3| 3| 3| 5| 3| 0| 0| 0| 3| 3| 3| 5|
| 1| 1| 1| 1| 1| 8| 1| 8| 1| 1| 1| 8| 1| 1| 1| 1| 8| 1| 0| 5| 4| 1| 0| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.3% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Inflammation, Chronic | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Congestion | 2 |
Degeneration, Cystic | 2 2 2 1 2 2 1 |
Fatty Change | 2 2 2 1 1 2 1 1 1 2 1 3 2 1 1|
Fibrosis, Focal | |
Focal Cellular Change | 2 2 2 1 2 2 2 2 2 1 2 2 1 3 2 |
Hematopoietic Cell Proliferation | 2 2 2 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | 2 |
Hyperplasia, Multifocal | 1 1 2 2 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 2 3 |
Inflammation, Focal | 2 2 2 1 1 2 2 2 2 1 2 1 2 2 1|
Necrosis, Focal | 2 |
Pigmentation | |
Bile Duct, Hyperplasia | 2 1 2 4 2 2 2 1 3 2 2 1 2 2 2 2 2 2 1 2 2 3 2 2 2|
Biliary Tract, Fibrosis | 2 1 2 3 2 2 2 1 2 1 1 2 2 2 1 2 1 1 2 2 2 1|
Centrilobular, Atrophy | 2 2 3 1 2 |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + |
Inflammation, Chronic | 3 |
Fat, Necrosis | 3 3 3 2 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 1 1 2 1 1 2 2 1 1 1 1 3|
Acinar Cell, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Focal Cellular Change | 2 |
Hyperplasia | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 4| 7| 6| 7| 5| 7| 6| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 5| 8| 3| 3| 5| 3| 3| 3| 3| 5| 3| 0| 0| 0| 3| 3| 3| 5|
| 1| 1| 1| 1| 1| 8| 1| 8| 1| 1| 1| 8| 1| 1| 1| 1| 8| 1| 0| 5| 4| 1| 0| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.3% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Edema | |
Erosion | |
Inflammation, Chronic | 2 1 |
Ulcer | 2 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mesenteric Artery, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
Artery, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Focal Cellular Change | 2 1 |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
Hemorrhage | 2 2 |
Pars Distalis, Focal Cellular Change | 1 1 |
Pars Distalis, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 4| 7| 6| 7| 5| 7| 6| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 5| 8| 3| 3| 5| 3| 3| 3| 3| 5| 3| 0| 0| 0| 3| 3| 3| 5|
| 1| 1| 1| 1| 1| 8| 1| 8| 1| 1| 1| 8| 1| 1| 1| 1| 8| 1| 0| 5| 4| 1| 0| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.3% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 3 3 3 1 3 2 2 2 2 2 3 1 1 3 2 3 2 2 2 3 3 3 2|
Hyperplasia | 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia | 1 2 |
Inflammation, Suppurative | 3 2 1 1 2 1 2 2 2 2 2 2 1 2 1 2|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypercellularity | 3 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 3 |
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 2 2 |
Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fibrosis | 2 2 2 2 4 |
Hematopoietic Cell Proliferation | 3 3 3 3 |
Necrosis, Focal | 3 |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + + M + + + +|
Dilatation | 2 1 2 2 |
Hemorrhage | |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 3 |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 4| 7| 6| 7| 5| 7| 6| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 5| 8| 3| 3| 5| 3| 3| 3| 3| 5| 3| 0| 0| 0| 3| 3| 3| 5|
| 1| 1| 1| 1| 1| 8| 1| 8| 1| 1| 1| 8| 1| 1| 1| 1| 8| 1| 0| 5| 4| 1| 0| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.3% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Exudate | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Hemorrhage | 3 |
Meninges, Angiectasis | |
Meninges, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Exudate | |
Fibrosis, Focal | |
Fungus | 2 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Macrophage | |
Infiltration Cellular, Mixed Cell | 2 1 2 |
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | 1 1 |
Mediastinum, Ectopic Tissue | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 2 1 1 2|
Inflammation, Suppurative | 2 2 2 1 1 2 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + |
Atrophy | 4 |
Cataract | 4 3 |
Retina, Degeneration | 4 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Nephropathy | 2 2 2 2 2 1 2 2 3 3 2 2 2 2 3 2 2 2 2 2 2 2 3 2|
Pigmentation | 3 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 4| 5| 7| 7| 4| 7| 7| 7| 7| 4| 7| 6| 7| 5| 7| 6| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 8| 3| 5| 8| 3| 3| 5| 3| 3| 3| 3| 5| 3| 0| 0| 0| 3| 3| 3| 5|
| 1| 1| 1| 1| 1| 8| 1| 8| 1| 1| 1| 8| 1| 1| 1| 1| 8| 1| 0| 5| 4| 1| 0| 1| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.3% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Artery, Inflammation, Chronic | 2 |
Pelvis, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 5| 1| 0| 3| 3| 3| 5| 3| | |
| 1| 1| 5| 8| 4| 1| 1| 1| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.3% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | 1 2 | 8 1.1|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
Parasite Metazoan | | 2 1.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
Congestion | | 1 1.0|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 2 | 2 2.0|
Congestion | | 1 2.0|
Degeneration, Cystic | 1 2 1 | 20 1.7|
Fatty Change | 2 1 2 2 1 | 37 1.5|
Fibrosis, Focal | | 1 2.0|
Focal Cellular Change | 2 2 1 2 2 1 | 29 1.8|
Hematopoietic Cell Proliferation | | 3 2.0|
Hemorrhage | | 1 3.0|
Hepatodiaphragmatic Nodule | 2 2 | 6 2.5|
Hyperplasia, Multifocal | 2 2 2 2 | 17 1.8|
Infiltration Cellular, Mixed Cell | | 5 2.2|
Inflammation, Focal | 2 2 2 2 1 2 | 36 1.7|
Necrosis, Focal | | 1 2.0|
Pigmentation | | 1 2.0|
Bile Duct, Hyperplasia | 2 2 2 3 2 2 3 2 1 2 | 60 2.1|
Biliary Tract, Fibrosis | 2 2 1 2 1 2 2 2 1 2 | 55 1.7|
Centrilobular, Atrophy | 3 2 | 14 2.2|
Centrilobular, Necrosis | | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | + + | 16 |
Inflammation, Chronic | 3 | 2 3.0|
Fat, Necrosis | 2 | 9 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy, Focal | 2 2 4 2 2 2 1 1 | 32 1.6|
Acinar Cell, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 5| 1| 0| 3| 3| 3| 5| 3| | |
| 1| 1| 5| 8| 4| 1| 1| 1| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.3% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Focal Cellular Change | | 1 2.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
Erosion | | 1 1.0|
Inflammation, Chronic | | 5 1.6|
Ulcer | | 2 2.5|
Mucosa, Hyperplasia | | 5 1.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
Erosion | | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 60 |
Ectopic Tissue | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 3 |
Mesenteric Artery, Inflammation, | | |
Chronic | 2 | 3 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Thrombosis | 3 | 2 3.0|
Artery, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 2 1.0|
Focal Cellular Change | 2 2 | 6 1.7|
Hematopoietic Cell Proliferation | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 2 1 1 | 12 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M | 55 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Cyst | | 3 1.7|
Hemorrhage | | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 5| 1| 0| 3| 3| 3| 5| 3| | |
| 1| 1| 5| 8| 4| 1| 1| 1| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.3% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Focal Cellular Change | 2 | 4 1.3|
Pars Distalis, Hyperplasia, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Ultimobranchial Cyst | | 1 1.0|
C-Cell, Hyperplasia | 2 | 5 1.8|
Follicle, Cyst | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 2 3 2 4 2 2 3 3 2 3 | 60 2.5|
Hyperplasia | | 3 2.0|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Dilatation | | 1 3.0|
Hyperplasia | 2 | 6 1.3|
Inflammation, Suppurative | 2 | 27 1.7|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Germinal Epithelium, Degeneration | 4 4 4 4 | 7 3.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hypercellularity | | 3 3.0|
Myelofibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Angiectasis | 3 | 2 3.0|
Mediastinal, Hemorrhage | | 1 3.0|
Mediastinal, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Angiectasis | 2 | 1 2.0|
Cyst | 2 | 3 2.0|
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Cyst | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 5| 1| 0| 3| 3| 3| 5| 3| | |
| 1| 1| 5| 8| 4| 1| 1| 1| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.3% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Fibrosis | | 12 2.3|
Hematopoietic Cell Proliferation | 4 | 6 3.2|
Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 58 |
Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 58 |
Dilatation | 2 | 8 2.0|
Hemorrhage | | 1 3.0|
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Cyst Epithelial Inclusion | | 1 3.0|
Exudate | | 1 1.0|
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 2 2.0|
Hemorrhage | | 2 2.5|
Meninges, Angiectasis | | 1 1.0|
Meninges, Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Exudate | | 1 2.0|
Fibrosis, Focal | 2 | 1 2.0|
Fungus | | 1 2.0|
Hemorrhage | 2 | 4 1.8|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Macrophage | 2 | 2 2.0|
Infiltration Cellular, Mixed Cell | | 3 1.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| | |
DAY ON TEST | 3| 3| 5| 1| 0| 3| 3| 3| 5| 3| | |
| 1| 1| 5| 8| 4| 1| 1| 1| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.3% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Chronic | 2 2 | 4 2.0|
Alveolar Epithelium, Hyperplasia | 3 1 2 1 | 10 1.6|
Mediastinum, Ectopic Tissue | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 2 2 2 | 16 1.9|
Inflammation, Suppurative | 2 3 2 | 18 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
Atrophy | | 1 4.0|
Cataract | | 2 3.5|
Retina, Degeneration | | 2 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 2 2.0|
Nephropathy | 3 3 2 2 2 2 2 2 1 2 | 59 2.1|
Pigmentation | | 2 3.0|
Artery, Inflammation, Chronic | | 1 2.0|
Pelvis, Dilatation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 6| 4| 7| 6| 5| 7| 6| 7| 7| 6| 7| 7| 4| 6| 6| 7| 7| 4| 7| 7| 4| 7| 6| 6| 4|
DAY ON TEST | 3| 5| 0| 4| 8| 2| 9| 3| 3| 9| 3| 3| 5| 2| 7| 3| 3| 5| 3| 3| 5| 3| 8| 9| 5|
| 4| 6| 1| 1| 9| 4| 3| 0| 0| 9| 0| 0| 6| 2| 4| 0| 0| 7| 0| 0| 7| 0| 3| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.6% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + M + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + M + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Degeneration, Cystic | 2 2 1 2 1 2 1 |
Fatty Change | 2 1 2 1 1 2 1 2 2 2 2 1 1 1|
Fibrosis, Focal | 2 |
Focal Cellular Change | 2 2 1 1 2 1 2 1 |
Hepatodiaphragmatic Nodule | 2 |
Hyperplasia, Multifocal | 2 2 2 2 3 2 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Focal | 2 2 2 2 2 1 2 2 2 2 1 2|
Necrosis, Focal | 1 1 |
Bile Duct, Hyperplasia | 3 2 2 3 2 2 2 2 2 2 2 2 1 2 1 2 2 2 2 2 1 2 3 2 1|
Biliary Tract, Fibrosis | 2 2 1 2 2 2 2 2 2 1 2 2 1 2 2 1 1 2 1 1 1 3 2 1|
Centrilobular, Atrophy | 3 2 2 2 4 3 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis | 3 3 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 2 2 1 2 1 1 1 1 1 1 2 1 2|
Acinar Cell, Hyperplasia | 1 2 1 1|
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 1 |
Inflammation, Chronic | 1 |
Ulcer | |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 1 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 6| 4| 7| 6| 5| 7| 6| 7| 7| 6| 7| 7| 4| 6| 6| 7| 7| 4| 7| 7| 4| 7| 6| 6| 4|
DAY ON TEST | 3| 5| 0| 4| 8| 2| 9| 3| 3| 9| 3| 3| 5| 2| 7| 3| 3| 5| 3| 3| 5| 3| 8| 9| 5|
| 4| 6| 1| 1| 9| 4| 3| 0| 0| 9| 0| 0| 6| 2| 4| 0| 0| 7| 0| 0| 7| 0| 3| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.6% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | |
Ulcer | |
Mucosa, Pigmentation | 1 |
__________________________________________________________________________|
Tongue | + + M + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mesenteric Artery, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 3 3 |
Epicardium, Inflammation, Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | |
Focal Cellular Change | 1 1 1 1 1 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hyperplasia | 1 2 2 2 2 1 |
Mineralization | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Pars Distalis, Focal Cellular Change | 2 1 1 |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Vacuolization | |
Cytoplasmic | 3 |
Rathke's Cleft, Hyperplasia, Cystic | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
C-Cell, Hyperplasia | 1 1 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Thoracic, Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 6| 4| 7| 6| 5| 7| 6| 7| 7| 6| 7| 7| 4| 6| 6| 7| 7| 4| 7| 7| 4| 7| 6| 6| 4|
DAY ON TEST | 3| 5| 0| 4| 8| 2| 9| 3| 3| 9| 3| 3| 5| 2| 7| 3| 3| 5| 3| 3| 5| 3| 8| 9| 5|
| 4| 6| 1| 1| 9| 4| 3| 0| 0| 9| 0| 0| 6| 2| 4| 0| 0| 7| 0| 0| 7| 0| 3| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.6% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 2 3 3 2 3 2 3 2 2 2 3 2 3 3 3 3 2 2 2 2 2 3 2|
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
Inflammation, Suppurative | 2 2 1 1 1 1 2 2 1 1 2 1 1 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 3 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 3 3 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 |
Cyst | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | 2 |
Fibrosis | 2 2 2 2 2 |
Hematopoietic Cell Proliferation | 3 3 |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Depletion Cellular | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 2 1 2 3 |
Fibrosis | |
Hemorrhage | |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 6| 4| 7| 6| 5| 7| 6| 7| 7| 6| 7| 7| 4| 6| 6| 7| 7| 4| 7| 7| 4| 7| 6| 6| 4|
DAY ON TEST | 3| 5| 0| 4| 8| 2| 9| 3| 3| 9| 3| 3| 5| 2| 7| 3| 3| 5| 3| 3| 5| 3| 8| 9| 5|
| 4| 6| 1| 1| 9| 4| 3| 0| 0| 9| 0| 0| 6| 2| 4| 0| 0| 7| 0| 0| 7| 0| 3| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.6% | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | |
Hemorrhage | |
Hyperplasia, Macrophage | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 1 2 1 2 2 2 2 |
Inflammation, Suppurative | 4 2 2 1 2 2 2 2 1|
Nasolacrimal Duct, Cyst | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 1 1 2 3 3 2 2 2 3 2 3 2 2 2 2 2 1 1 2 2 2 1 3 1|
__________________________________________________________________________|
Urethra | |
Bulbourethral Gland, Dilatation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 6| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 5| 6| 3| 3| 5| 3| 3| 1| 3| 5| 9| 3| 5|
| 0| 0| 0| 0| 0| 0| 0| 3| 0| 0| 0| 8| 7| 8| 0| 0| 7| 0| 0| 0| 0| 8| 1| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.6% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Degeneration, Cystic | 2 1 1 2 2 |
Fatty Change | 1 1 2 1 1 1 1 1 2 1 2 1|
Fibrosis, Focal | |
Focal Cellular Change | 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 |
Hepatodiaphragmatic Nodule | 2 3 |
Hyperplasia, Multifocal | 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 |
Inflammation, Focal | 2 2 1 2 2 2 2 2 2 1 1 1 1 2 2 2 2 1 2 1|
Necrosis, Focal | |
Bile Duct, Hyperplasia | 2 2 2 2 1 3 2 3 2 2 2 2 2 2 2 2 1 3 2 3 2 2 2 2|
Biliary Tract, Fibrosis | 1 2 1 2 2 2 2 2 2 2 1 1 2 1 1 1 2 2 2 2 2 2 1|
Centrilobular, Atrophy | 2 2 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 2 2 3 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 2 1 2 2 1 2 3 1 2 |
Acinar Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | |
Inflammation, Chronic | |
Ulcer | |
Mucosa, Hyperplasia | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 6| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 5| 6| 3| 3| 5| 3| 3| 1| 3| 5| 9| 3| 5|
| 0| 0| 0| 0| 0| 0| 0| 3| 0| 0| 0| 8| 7| 8| 0| 0| 7| 0| 0| 0| 0| 8| 1| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.6% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Inflammation, Chronic | 2 |
Ulcer | 2 |
Mucosa, Pigmentation | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mucosa, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mesenteric Artery, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
Epicardium, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Congestion | |
Focal Cellular Change | 2 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hyperplasia | 1 1 1 1 1 2 |
Mineralization | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Cyst | 2 2 2 |
Pars Distalis, Focal Cellular Change | 1 1 1|
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Vacuolization | |
Cytoplasmic | |
Rathke's Cleft, Hyperplasia, Cystic | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
C-Cell, Hyperplasia | 1 1 |
Follicular Cell, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Thoracic, Metaplasia, Osseous | 2 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 6| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 5| 6| 3| 3| 5| 3| 3| 1| 3| 5| 9| 3| 5|
| 0| 0| 0| 0| 0| 0| 0| 3| 0| 0| 0| 8| 7| 8| 0| 0| 7| 0| 0| 0| 0| 8| 1| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.6% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 1 2 3 2 4 3 3 2 3 2 3 2 3 2 3 2 3 4 4 4 2 1 3 2|
Inflammation, Chronic | 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 1 2 1 1 2 2 1 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 3 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 3 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Fibrosis | 1 2 |
Hematopoietic Cell Proliferation | |
Necrosis, Focal | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +|
Cyst | |
Depletion Cellular | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Dilatation | 4 |
Fibrosis | |
Hemorrhage | 4 |
Hyperplasia | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 6| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7| 4|
DAY ON TEST | 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 5| 5| 6| 3| 3| 5| 3| 3| 1| 3| 5| 9| 3| 5|
| 0| 0| 0| 0| 0| 0| 0| 3| 0| 0| 0| 8| 7| 8| 0| 0| 7| 0| 0| 0| 0| 8| 1| 0| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.6% | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma | 1 |
Hemorrhage | 3 |
Hyperplasia, Macrophage | |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 1 2 2 2 |
Inflammation, Suppurative | 2 2 1 1 2 1 2 2 2 2 2 |
Nasolacrimal Duct, Cyst | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
Retina, Degeneration | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 3 2 2 2 2 3 2 1 2 2 2 1 3 2 2 2 2 2 2 2 1 2 2 2|
__________________________________________________________________________|
Urethra | + |
Bulbourethral Gland, Dilatation | 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 7| 6| 7| 7| 6| 7| | |
DAY ON TEST | 3| 3| 5| 5| 3| 9| 3| 3| 4| 3| | |
| 0| 0| 7| 8| 0| 6| 0| 0| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.6% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Parasite Metazoan | 2 | 2 1.5|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
Parasite Metazoan | 2 | 3 1.3|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Degeneration, Cystic | 1 2 | 14 1.6|
Fatty Change | 2 1 4 1 2 1 1 | 33 1.5|
Fibrosis, Focal | | 1 2.0|
Focal Cellular Change | 2 1 2 2 2 | 28 1.8|
Hepatodiaphragmatic Nodule | 2 | 4 2.3|
Hyperplasia, Multifocal | 3 2 | 11 2.2|
Infiltration Cellular, Mixed Cell | 2 2 | 5 2.0|
Inflammation, Focal | 2 2 1 2 2 | 37 1.7|
Necrosis, Focal | 2 | 3 1.3|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 3 2 | 59 2.0|
Biliary Tract, Fibrosis | 1 2 2 2 2 2 2 2 2 2 | 57 1.7|
Centrilobular, Atrophy | 4 3 2 2 | 15 2.5|
__________________________________________________________________________|____________|
Mesentery | + + | 13 |
Fat, Necrosis | 3 | 10 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy, Focal | 1 1 1 1 1 | 30 1.4|
Acinar Cell, Hyperplasia | 1 1 | 7 1.3|
__________________________________________________________________________|____________|
Pharynx | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Atrophy, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | 3 | 1 3.0|
Erosion | | 1 1.0|
Inflammation, Chronic | 1 | 2 1.0|
Ulcer | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 7| 6| 7| 7| 6| 7| | |
DAY ON TEST | 3| 3| 5| 5| 3| 9| 3| 3| 4| 3| | |
| 0| 0| 7| 8| 0| 6| 0| 0| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.6% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Mucosa, Hyperplasia | 1 | 3 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Edema | 2 | 1 2.0|
Erosion | 1 1 | 3 1.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Ulcer | | 1 2.0|
Mucosa, Pigmentation | | 1 1.0|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 59 |
Mucosa, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
Mesenteric Artery, Inflammation, | | |
Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Thrombosis | | 2 3.0|
Epicardium, Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Angiectasis | | 1 1.0|
Congestion | 2 | 1 2.0|
Focal Cellular Change | 2 | 7 1.3|
Vacuolization Cytoplasmic | 3 | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Fibrosis | | 1 2.0|
Hyperplasia | 2 2 2 2 | 16 1.6|
Mineralization | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + | 58 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Cyst | 1 | 4 1.8|
Pars Distalis, Focal Cellular Change | 2 | 7 1.3|
Pars Distalis, Hyperplasia, Focal | | 2 2.0|
Pars Distalis, Vacuolization | | |
Cytoplasmic | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 7| 6| 7| 7| 6| 7| | |
DAY ON TEST | 3| 3| 5| 5| 3| 9| 3| 3| 4| 3| | |
| 0| 0| 7| 8| 0| 6| 0| 0| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.6% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Rathke's Cleft, Hyperplasia, Cystic | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Fibrosis, Focal | | 1 2.0|
C-Cell, Hyperplasia | 2 | 6 1.2|
Follicular Cell, Hyperplasia | | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Thoracic, Metaplasia, Osseous | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 3 3 2 2 2 2 4 4 3 4 | 59 2.6|
Inflammation, Chronic | 4 | 4 3.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Hyperplasia | | 2 1.0|
Inflammation, Suppurative | 1 2 2 | 26 1.4|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Germinal Epithelium, Degeneration | 4 | 8 3.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 60 |
Mediastinal, Angiectasis | | 5 2.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Angiectasis | | 2 2.5|
Cyst | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Developmental Malformation | | 1 2.0|
Fibrosis | 2 2 2 | 10 1.9|
Hematopoietic Cell Proliferation | | 2 3.0|
Necrosis, Focal | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 58 |
Cyst | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 7| 6| 7| 7| 6| 7| | |
DAY ON TEST | 3| 3| 5| 5| 3| 9| 3| 3| 4| 3| | |
| 0| 0| 7| 8| 0| 6| 0| 0| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.6% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Depletion Cellular | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + | 58 |
Dilatation | 1 2 | 8 2.0|
Fibrosis | 2 | 1 2.0|
Hemorrhage | | 1 4.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Epidermis, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Hyperostosis | | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | 2 | 1 2.0|
Hemorrhage | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Granuloma | | 1 1.0|
Hemorrhage | 2 1 | 3 2.0|
Hyperplasia, Macrophage | 1 3 | 2 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | 2 2 1 | 15 1.7|
Inflammation, Suppurative | 2 2 2 | 23 1.9|
Nasolacrimal Duct, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 4.0|
Retina, Degeneration | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 7| 7| 4| 4| 7| 6| 7| 7| 6| 7| | |
DAY ON TEST | 3| 3| 5| 5| 3| 9| 3| 3| 4| 3| | |
| 0| 0| 7| 8| 0| 6| 0| 0| 4| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.6% | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy | 2 3 1 2 3 2 2 2 2 4 | 60 2.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
Bulbourethral Gland, Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 4| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 6| 4| 7| 4| 7|
DAY ON TEST | 5| 2| 4| 8| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5| 2| 2| 2| 5| 2| 2| 3| 5| 2| 3| 2|
| 6| 4| 4| 6| 9| 9| 9| 9| 6| 9| 9| 9| 9| 6| 9| 9| 9| 6| 9| 9| 0| 6| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.2% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Parasite Metazoan | 1 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + I|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Inflammation, Chronic | |
Metaplasia, Osseous | |
Mucosa, Dysplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 2 1 2 1 1 1|
Fatty Change | 1 3 1 1 2 1 1 1 2 1 1 1|
Focal Cellular Change | 1 1 2 2 2 2 1 1 2 2 2 1|
Hepatodiaphragmatic Nodule | |
Hyperplasia, Multifocal | 2 2 2 2 2 2 1|
Infiltration Cellular, Mixed Cell | 2 2 2 2 |
Inflammation, Focal | 1 2 1 2 2 1 2 2 1 1 1 1 1 1 1 2|
Necrosis, Focal | |
Bile Duct, Dilatation | |
Bile Duct, Hyperplasia | 1 3 3 4 2 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2|
Biliary Tract, Fibrosis | 1 2 2 4 1 2 2 2 1 3 2 2 2 1 1 1 2 1 2 2 2 1 1 1 2|
Centrilobular, Atrophy | 2 4 3 1 |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Chronic | |
Fat, Necrosis | 1 1 2 3 3 |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 3 1 1 1 1 3 1 3 1 2 2 1 |
Focal Cellular Change | |
Acinar Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + M + + + +|
Dilatation | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
_____________________________________________________________________________________________________________________|
Page 96
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 4| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 6| 4| 7| 4| 7|
DAY ON TEST | 5| 2| 4| 8| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5| 2| 2| 2| 5| 2| 2| 3| 5| 2| 3| 2|
| 6| 4| 4| 6| 9| 9| 9| 9| 6| 9| 9| 9| 9| 6| 9| 9| 9| 6| 9| 9| 0| 6| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.2% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | |
Inflammation, Chronic | |
Ulcer | |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | +|
Incisor, Dysplasia | 1|
Incisor, Inflammation, Suppurative | 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + +|
Mesenteric Artery, Inflammation, | |
Chronic | 2 2 2|
Thoracic, Artery, Inflammation, | |
Chronic | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Focal Cellular Change | 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 2 1 1 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + M + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + A + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
Pars Distalis, Focal Cellular Change | 1 2 1 |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Nervosa, Focal Cellular Change | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + A + + + + + + + + + + + + + + + + M + + + +|
Pigmentation | |
C-Cell, Hyperplasia | 2 2 |
Follicle, Cyst | 2|
Follicular Cell, Hyperplasia | 1 1|
_____________________________________________________________________________________________________________________|
Page 97
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 4| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 6| 4| 7| 4| 7|
DAY ON TEST | 5| 2| 4| 8| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5| 2| 2| 2| 5| 2| 2| 3| 5| 2| 3| 2|
| 6| 4| 4| 6| 9| 9| 9| 9| 6| 9| 9| 9| 9| 6| 9| 9| 9| 6| 9| 9| 0| 6| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.2% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 4 3 1 2 2 3 2 3 1 3 3 2 2 3 2 2 3 3 2 2 3 3 3|
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Hyperplasia | 1 |
Inflammation, Suppurative | 3 3 2 1 2 2 1 1 2 2 1 1 |
Vacuolization Cytoplasmic | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 4 4 4 4 4 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hypocellularity | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + A + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | |
Mediastinal, Hyperplasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + A + + + + + + + + + + + + + + + + M + + + +|
Angiectasis | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + A + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 4 |
Hyperplasia | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 1 3 2 2 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Histiocytic | |
__________________________________________________________________________|
Thymus | + + + A + M M + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 1 3 |
Fibrosis | |
Hemorrhage | |
Hyperplasia | 1 2 |
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 4| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 6| 4| 7| 4| 7|
DAY ON TEST | 5| 2| 4| 8| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5| 2| 2| 2| 5| 2| 2| 3| 5| 2| 3| 2|
| 6| 4| 4| 6| 9| 9| 9| 9| 6| 9| 9| 9| 9| 6| 9| 9| 9| 6| 9| 9| 0| 6| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.2% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Trabecula, Proliferation | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Hemorrhage | |
Meninges, Hemorrhage | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 2 2 |
Hyperplasia, Lymphoid | 1 |
Hyperplasia, Macrophage | 2 |
Inflammation, Chronic | 2 1 |
Alveolar Epithelium, Hyperplasia | 2 3 1 |
Mediastinum, Cyst | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Fungus | 3 2 2 2 2 |
Inflammation, Suppurative | 3 2 2 1 1 2 2 1 2 |
Mucosa, Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Eye | |
Inflammation, Chronic | |
Cornea, Necrosis | |
Retrobulbar, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Zymbal's Gland | + |
Dilatation | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Nephropathy | 1 3 2 1 3 1 2 2 1 2 2 2 3 2 2 1 2 1 2 2 1 1 2 2 3|
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 4| 7| 6| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 7| 4| 7| 7| 6| 4| 7| 4| 7|
DAY ON TEST | 5| 2| 4| 8| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5| 2| 2| 2| 5| 2| 2| 3| 5| 2| 3| 2|
| 6| 4| 4| 6| 9| 9| 9| 9| 6| 9| 9| 9| 9| 6| 9| 9| 9| 6| 9| 9| 0| 6| 9| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
1.2% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 6| 4| 7| 5| 5| 7| 6| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 5| 2| 8| 3| 2| 6| 2| 5| 2| 2| 2| 2| 3| 5| 3| 3| 3| 1| 1| 7| 3| 3| 3| 3|
| 8| 6| 9| 4| 9| 9| 8| 9| 6| 9| 9| 9| 9| 0| 7| 0| 0| 0| 5| 3| 3| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.2% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Parasite Metazoan | 2|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 1 2 1 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 3 |
Inflammation, Chronic | 3 |
Metaplasia, Osseous | 3 |
Mucosa, Dysplasia | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 1 2 |
Fatty Change | 1 1 1 2 1 1 2 1 2 2 2 2 2 2 1 2 1|
Focal Cellular Change | 2 2 2 2 2 2 1 2 2 2 2 2 1 2|
Hepatodiaphragmatic Nodule | 3 3 2|
Hyperplasia, Multifocal | 2 2 2 2 2 2 3 2 2|
Infiltration Cellular, Mixed Cell | 2 2 |
Inflammation, Focal | 1 1 1 2 1 1 1 2 2 1 1 2 2 2 2 2 2|
Necrosis, Focal | 1 |
Bile Duct, Dilatation | 2 |
Bile Duct, Hyperplasia | 2 2 2 2 1 2 2 2 2 2 3 2 2 2 2 3 3 2 3 2 1 2 2 1 2|
Biliary Tract, Fibrosis | 2 1 2 1 1 2 1 2 2 2 2 2 1 2 1 2 3 2 3 1 1 1 1 2|
Centrilobular, Atrophy | 2 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Chronic | |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 1 1 1 2 2 1 1 1 1 2|
Focal Cellular Change | 1 2|
Acinar Cell, Hyperplasia | 3 2 |
__________________________________________________________________________|
Pharynx | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 6| 4| 7| 5| 5| 7| 6| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 5| 2| 8| 3| 2| 6| 2| 5| 2| 2| 2| 2| 3| 5| 3| 3| 3| 1| 1| 7| 3| 3| 3| 3|
| 8| 6| 9| 4| 9| 9| 8| 9| 6| 9| 9| 9| 9| 0| 7| 0| 0| 0| 5| 3| 3| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.2% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | |
Inflammation, Chronic | |
Ulcer | |
Mucosa, Hyperplasia | 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | |
Pigmentation | |
__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Incisor, Dysplasia | |
Incisor, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | |
Mesenteric Artery, Inflammation, | |
Chronic | |
Thoracic, Artery, Inflammation, | |
Chronic | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 |
Focal Cellular Change | 2 2 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1|
Cyst | 1 |
Pars Distalis, Focal Cellular Change | 1 1 |
Pars Distalis, Hyperplasia, Focal | 2 2 |
Pars Nervosa, Focal Cellular Change | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation | |
C-Cell, Hyperplasia | 1 1 2 |
Follicle, Cyst | 2 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 6| 4| 7| 5| 5| 7| 6| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 5| 2| 8| 3| 2| 6| 2| 5| 2| 2| 2| 2| 3| 5| 3| 3| 3| 1| 1| 7| 3| 3| 3| 3|
| 8| 6| 9| 4| 9| 9| 8| 9| 6| 9| 9| 9| 9| 0| 7| 0| 0| 0| 5| 3| 3| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.2% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 2 1 3 2 3 3 3 2 3 3 4 3 2 2 3 3 3 3 3 2 3 3 3 4|
Inflammation, Chronic | 4 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia | |
Inflammation, Suppurative | 2 2 2 1 2 1 1 2 2 1 1 1 1 |
Vacuolization Cytoplasmic | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 2 4 4 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypocellularity | 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Angiectasis | 3 |
Mediastinal, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Cyst | 3 4 |
Hyperplasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 2 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Histiocytic | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 4 2 3 |
Fibrosis | 2 |
Hemorrhage | 3 |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 6| 4| 7| 5| 5| 7| 6| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 5| 2| 8| 3| 2| 6| 2| 5| 2| 2| 2| 2| 3| 5| 3| 3| 3| 1| 1| 7| 3| 3| 3| 3|
| 8| 6| 9| 4| 9| 9| 8| 9| 6| 9| 9| 9| 9| 0| 7| 0| 0| 0| 5| 3| 3| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.2% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Trabecula, Proliferation | |
__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Hemorrhage | |
Meninges, Hemorrhage | 2|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Hyperplasia, Lymphoid | |
Hyperplasia, Macrophage | 3 1 |
Inflammation, Chronic | |
Alveolar Epithelium, Hyperplasia | |
Mediastinum, Cyst | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | 2 2 2 2 2 1 2 3 |
Inflammation, Suppurative | 4 2 2 2 2 1 2 3 |
Mucosa, Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Inflammation, Suppurative | |
__________________________________________________________________________|
Eye | + I |
Inflammation, Chronic | 4 |
Cornea, Necrosis | 4 |
Retrobulbar, Inflammation, | |
Suppurative | |
__________________________________________________________________________|
Zymbal's Gland | + |
Dilatation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2|
Nephropathy | 2 1 2 1 1 2 3 2 1 2 2 2 2 1 2 2 1 2 1 2 2 3 3 1 3|
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
_____________________________________________________________________________________________________________________
| 6| 4| 7| 5| 5| 7| 6| 7| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 5| 7| 7| 6| 7|
DAY ON TEST | 3| 5| 2| 8| 3| 2| 6| 2| 5| 2| 2| 2| 2| 3| 5| 3| 3| 3| 1| 1| 7| 3| 3| 3| 3|
| 8| 6| 9| 4| 9| 9| 8| 9| 6| 9| 9| 9| 9| 0| 7| 0| 0| 0| 5| 3| 3| 0| 0| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.2% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 4| 7| 5| 7| 7| 4| 5| 7| 7| 6| | |
DAY ON TEST | 5| 2| 0| 3| 3| 5| 4| 3| 3| 4| | |
| 7| 4| 1| 0| 0| 7| 6| 0| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.2% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
Parasite Metazoan | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Cyst | | 1 3.0|
Parasite Metazoan | | 3 1.3|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
Parasite Metazoan | 2 | 7 1.3|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + I + + | 58 |
Diverticulum | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Metaplasia, Osseous | | 1 3.0|
Mucosa, Dysplasia | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Degeneration, Cystic | 1 | 14 1.3|
Fatty Change | 2 3 2 2 1 2 | 35 1.5|
Focal Cellular Change | 2 2 2 | 29 1.8|
Hepatodiaphragmatic Nodule | 3 | 4 2.8|
Hyperplasia, Multifocal | 2 2 | 18 2.0|
Infiltration Cellular, Mixed Cell | 2 | 7 2.0|
Inflammation, Focal | 2 2 1 2 2 | 38 1.5|
Necrosis, Focal | 2 | 2 1.5|
Bile Duct, Dilatation | | 1 2.0|
Bile Duct, Hyperplasia | 2 2 3 1 2 1 3 2 2 3 | 60 2.1|
Biliary Tract, Fibrosis | 2 2 2 1 2 1 2 1 3 | 58 1.7|
Centrilobular, Atrophy | 2 2 2 3 | 10 2.3|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + | 11 |
Inflammation, Chronic | 2 | 1 2.0|
Fat, Necrosis | 2 3 | 9 2.2|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Atrophy, Focal | 1 1 2 1 3 2 | 30 1.5|
Focal Cellular Change | 1 1 | 4 1.3|
Acinar Cell, Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Pharynx | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 4| 7| 5| 7| 7| 4| 5| 7| 7| 6| | |
DAY ON TEST | 5| 2| 0| 3| 3| 5| 4| 3| 3| 4| | |
| 7| 4| 1| 0| 0| 7| 6| 0| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.2% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Dilatation | | 1 3.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
Erosion | 1 | 1 1.0|
Inflammation, Chronic | 1 | 1 1.0|
Ulcer | 2 | 1 2.0|
Mucosa, Hyperplasia | 2 | 3 1.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
Erosion | 1 2 | 3 1.7|
Pigmentation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Incisor, Dysplasia | | 1 1.0|
Incisor, Inflammation, Suppurative | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 6 |
Mesenteric Artery, Inflammation, | | |
Chronic | 2 2 | 5 2.0|
Thoracic, Artery, Inflammation, | | |
Chronic | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Dilatation | 3 | 1 3.0|
Thrombosis | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 1 2.0|
Focal Cellular Change | | 6 1.5|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 1 | 13 1.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 58 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 4| 7| 5| 7| 7| 4| 5| 7| 7| 6| | |
DAY ON TEST | 5| 2| 0| 3| 3| 5| 4| 3| 3| 4| | |
| 7| 4| 1| 0| 0| 7| 6| 0| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.2% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Angiectasis | | 1 1.0|
Cyst | | 1 1.0|
Pars Distalis, Focal Cellular Change | 1 | 6 1.2|
Pars Distalis, Hyperplasia, Focal | | 3 2.0|
Pars Nervosa, Focal Cellular Change | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 58 |
Pigmentation | 1 | 1 1.0|
C-Cell, Hyperplasia | 2 2 | 7 1.7|
Follicle, Cyst | | 2 2.0|
Follicular Cell, Hyperplasia | | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Degeneration, Cystic | 2 3 2 3 3 2 1 3 3 3 | 60 2.6|
Inflammation, Chronic | | 3 4.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Dilatation | | 1 4.0|
Hyperplasia | | 1 1.0|
Inflammation, Suppurative | 3 2 1 | 28 1.6|
Vacuolization Cytoplasmic | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Dilatation | | 1 4.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Germinal Epithelium, Degeneration | 4 | 11 3.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Hypocellularity | | 1 3.0|
Myelofibrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 59 |
Mediastinal, Angiectasis | | 1 3.0|
Mediastinal, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 4| 7| 5| 7| 7| 4| 5| 7| 7| 6| | |
DAY ON TEST | 5| 2| 0| 3| 3| 5| 4| 3| 3| 4| | |
| 7| 4| 1| 0| 0| 7| 6| 0| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.2% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Angiectasis | | 2 2.0|
Cyst | | 3 3.7|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | 2 | 8 2.4|
Hematopoietic Cell Proliferation | 2 | 3 2.7|
Hyperplasia, Histiocytic | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + | 55 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | 1 | 8 2.1|
Fibrosis | | 1 2.0|
Hemorrhage | | 1 3.0|
Hyperplasia | | 3 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Trabecula, Proliferation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 2 4.0|
Hemorrhage | 3 | 1 3.0|
Meninges, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | | 4 1.8|
Hyperplasia, Lymphoid | | 1 1.0|
Hyperplasia, Macrophage | | 3 2.0|
Inflammation, Chronic | | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 3 2.0|
Mediastinum, Cyst | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Foreign Body | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 109
NTP Experiment-Test: 05120-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZYL ACETATE Date: 04/24/97
Route: DOSED FEED Time: 14:28:26
__________________________________________________________________________________________________________________________________
| 4| 7| 5| 7| 7| 4| 5| 7| 7| 6| | |
DAY ON TEST | 5| 2| 0| 3| 3| 5| 4| 3| 3| 4| | |
| 7| 4| 1| 0| 0| 7| 6| 0| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.2% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Fungus | 1 | 14 2.0|
Inflammation, Suppurative | 1 | 18 1.9|
Mucosa, Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Eye | + | 2 |
Inflammation, Chronic | | 1 4.0|
Cornea, Necrosis | | 1 4.0|
Retrobulbar, Inflammation, | | |
Suppurative | 3 | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Dilatation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 2 2.5|
Nephropathy | 1 2 1 2 3 2 2 2 2 2 | 60 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 110
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