TDMS Study 05120-03 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/15/94
EXP: 05120 BENZYL ACETATE TIME: 14:10:36
TEST: 03 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 06508B
CONT: N01-ES-55082 CAS: 140-11-4
PATHOLOGIST: DR FARNELL SCOT EUSTIS
--------------------------------------------------------------------------------
REASONS FOR REMOVAL:
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REMOVAL DATE RANGE:
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TREATMENT GROUPS:
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst DATE: 09/15/94
EXP: 05120 BENZYL ACETATE TIME: 14:10:36
TEST: 03 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP C#: 06508B
CONT: N01-ES-55082 CAS: 140-11-4
PATHOLOGIST: DR FARNELL SCOT EUSTIS
BENZYL ACETATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 23 CENSORED DEATHS 10 TERMINAL 27 |
| |
| UNCENSORED DEATHS |
| 467 487 495 525 542 560 574 600 600 631 |
| 633 643 654 668 682 705 705 710 714 724 |
| 725 725 725 |
| CENSORED DEATHS |
| 456 456 456 457 457 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.3% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 16 CENSORED DEATHS 10 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 396 488 504 528 553 570 581 600 618 630 |
| 633 655 693 704 705 710 |
| CENSORED DEATHS |
| 456 456 457 457 457 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.6% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 10 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 457 491 589 622 633 634 641 644 658 668 |
| 674 683 693 696 697 699 701 710 710 724 |
| CENSORED DEATHS |
| 456 456 457 457 457 457 457 458 458 458 |
| |
==================================================================================
BENZYL ACETATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1.2% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 17 CENSORED DEATHS 10 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 431 501 539 546 573 584 613 630 631 638 |
| 643 644 668 686 715 724 724 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 457 457 457 |
| |
==================================================================================
BENZYL ACETATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0% | 100.0 100.0 100.0 100.0 100.0 98.0 90.0 82.0 74.0 54.0 |
| | |
| | |
|0.3% | 100.0 100.0 100.0 100.0 98.3 98.3 92.3 84.3 76.3 68.2 |
| | |
| | |
|0.6% | 100.0 100.0 100.0 100.0 100.0 98.3 96.3 94.3 82.2 60.2 |
| | |
| | |
|1.2% | 100.0 100.0 100.0 100.0 100.0 98.3 94.3 88.3 76.3 66.2 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0% 0.3% 0.6% 1.2% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 54.0% 68.2% 60.2% 66.2% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.455N P=0.291N P=0.632N P=0.346N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 630.2 598.0 651.2 617.1 |
|NATURAL DEATHS (C) | (17.7) (22.4) (15.7) (19.6) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 645.8 648.8 657.8 651.8 |
|(STANDARD ERROR) | (14.1) (14.5) (13.5) (14.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BENZYL ACETATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 10 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 420 508 525 560 584 603 606 627 631 634 |
| 658 693 693 696 704 708 710 721 724 727 |
| CENSORED DEATHS |
| 456 456 457 457 457 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.3% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 20 CENSORED DEATHS 10 TERMINAL 30 |
| |
| UNCENSORED DEATHS |
| 430 487 520 584 584 621 633 654 654 655 |
| 693 696 701 704 707 710 710 710 710 726 |
| CENSORED DEATHS |
| 456 456 457 457 457 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.6% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 13 CENSORED DEATHS 10 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 367 521 592 696 700 707 710 711 711 715 |
| 725 725 727 |
| CENSORED DEATHS |
| 456 457 457 457 457 457 457 458 458 458 |
| |
==================================================================================
BENZYL ACETATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1.2% |
| --------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 22 CENSORED DEATHS 10 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 553 582 593 631 641 658 667 668 668 668 |
| 669 672 693 700 704 707 707 707 707 708 |
| 715 726 |
| CENSORED DEATHS |
| 456 456 456 456 456 456 456 457 457 457 |
| |
==================================================================================
BENZYL ACETATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 731 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 731 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0% | 100.0 100.0 100.0 100.0 98.3 98.3 94.3 88.3 78.3 60.2 |
| | |
| | |
|0.3% | 100.0 100.0 100.0 100.0 100.0 98.3 94.3 90.3 80.3 60.2 |
| | |
| | |
|0.6% | 100.0 100.0 100.0 100.0 98.3 98.3 96.3 94.3 94.3 74.3 |
| | |
| | |
|1.2% | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 94.0 88.0 56.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0% 0.3% 0.6% 1.2% |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 60.2% 60.2% 74.3% 56.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.946 P=1.000N P=0.134N P=0.924 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 636.6 644.5 662.1 670.2 |
|NATURAL DEATHS (C) | (18.9) (18.8) (29.8) ( 9.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 653.9 656.5 670.4 662.9 |
|(STANDARD ERROR) | (14.1) (14.1) (14.4) (13.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
BENZYL ACETATE
KAPLAN-MEIER SURVIVAL CURVES
0% = 1
0.3% = 2
0.6% = 3
1.2% = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 2 4 31
| 2 4 3 234
| 1 1
| 112 4 3
95 +
| 12 1244 3 3
| 12 12 4 3 3
|
90 + 121 2 4
| 224 4 33
| 1 1
| 12 1 4 4
P 85 +
E | 2 2443 3
R | 1 2214 3 3
C |
E 80 + 22 33
N | 2 2 33
T | 11
| 1 1 4 32
S 75 +
U | 1 1 4232
R | 1 1 4
V |
I 70 + 1 1244
V | 332 2
A |
L | 11 4 4
65 +
|
| 1 1
|
60 + 3 3
|
|
|
55 +
| 1 1
|
|
50 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 21 obs hidden.
BENZYL ACETATE
KAPLAN-MEIER SURVIVAL CURVES
0% = 1
0.3% = 2
0.6% = 3
1.2% = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 2 4
| 3 1 2 2 1 3
| 4 4
| 2 1 1 4 3
95 +
| 1 1 2 3 4 3
| 1 1 44
|
90 + 1 1 2 4 4 33
| 2 2 33
P | 4 4
E | 1 12 2
R 85 +
C | 11
E | 33
N |
T 80 + 1 1 2 33
| 1 12
S |
U | 4 422
R 75 +
V | 11 3 3
I | 11
V |
A 70 + 11
L |
|
| 11
65 +
| 11
| 42 2
|
60 + 441 1
|
| 44
| 4 4
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 20 obs hidden.