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TDMS Study 05121-07 Pathology Tables

NTP Experiment-Test: 05121-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96
Route: GAVAGE                                                                                                     Time: 22:04:19




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  6533-68-2

       Lock Date:  06/01/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05121-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          70           60           70           70           70                        

  Scheduled Sacrifice                                 10           10           10           10           10                        
  Early Deaths                                                                                                                      
    Natural Death                                      7            3            3            5            6                        
    Moribund Sacrifice                                 9           10           11            7            7                        
    Dosing Accident                                    2            1                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           36           36           37           38                        

  Animals Examined Microscopically                    61           60           60           60           61                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (61)         (60)         (59)         (59)         (61)                      
   Intestine Large, Rectum                            (61)         (60)         (60)         (60)         (60)                      
      Anus, Sarcoma                                                                           1 (2%)                                
   Intestine Small, Duodenum                          (61)         (60)         (59)         (60)         (61)                      
      Hemangiosarcoma                                                                         1 (2%)                                
   Intestine Small, Jejunum                           (61)         (58)         (59)         (60)         (60)                      
      Carcinoma                                        1 (2%)                                                                       
   Liver                                              (61)         (60)         (60)         (60)         (61)                      
      Hemangiosarcoma                                                            1 (2%)                                             
      Hemangiosarcoma, Multiple                        1 (2%)                                                                       
      Hepatocellular Carcinoma                         7 (11%)      2 (3%)       5 (8%)       5 (8%)       4 (7%)                   
      Hepatocellular Carcinoma, Multiple               1 (2%)                    1 (2%)       3 (5%)                                
      Hepatocellular Adenoma                          11 (18%)      7 (12%)     13 (22%)      9 (15%)      4 (7%)                   
      Hepatocellular Adenoma, Multiple                 5 (8%)                    5 (8%)                    2 (3%)                   
      Hepatocholangiocarcinoma                         1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)       3 (5%)       2 (3%)                    1 (2%)                   
      Bile Duct, Carcinoma                             1 (2%)                                                                       
   Mesentery                                          (7)          (5)          (9)          (4)          (5)                       
      Carcinoma, Metastatic, Liver                     1 (14%)                                                                      
      Histiocytic Sarcoma                                           1 (20%)                                1 (20%)                  
      Lipoma                                                        1 (20%)                                                         
   Pancreas                                           (61)         (60)         (60)         (60)         (61)                      
      Carcinoma, Metastatic, Liver                     1 (2%)                                                                       
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Salivary Glands                                    (60)         (60)         (60)         (60)         (61)                      
   Stomach, Forestomach                               (61)         (60)         (60)         (60)         (61)                      
      Mast Cell Tumor Benign                                                                  1 (2%)                                
      Squamous Cell Papilloma                                       1 (2%)                    1 (2%)       2 (3%)                   
   Stomach, Glandular                                 (61)         (60)         (60)         (60)         (61)                      
   Tongue                                                          (1)                                                              

                                                             Page   2                                                               
NTP Experiment-Test: 05121-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Carcinoma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (61)         (60)         (60)         (60)         (61)                      
      Carcinoma, Metastatic, Liver                     1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (61)         (60)         (60)         (60)         (61)                      
      Capsule, Adenoma                                                           1 (2%)                                             
   Adrenal Medulla                                    (61)         (58)         (59)         (59)         (60)                      
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                                                    2 (3%)                                             
   Islets, Pancreatic                                 (61)         (60)         (60)         (60)         (61)                      
      Adenoma                                                                    1 (2%)       1 (2%)                                
   Pituitary Gland                                    (60)         (58)         (57)         (57)         (56)                      
      Pars Distalis, Adenoma                           4 (7%)       1 (2%)       3 (5%)       3 (5%)       3 (5%)                   
      Pars Intermedia, Adenoma                                                   1 (2%)                    1 (2%)                   
   Thyroid Gland                                      (61)         (60)         (59)         (60)         (61)                      
      Follicular Cell, Adenoma                         3 (5%)       1 (2%)                                 3 (5%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (61)         (59)         (59)         (59)         (61)                      
      Cystadenoma                                      4 (7%)                                 3 (5%)       1 (2%)                   
      Fibroma                                                                    1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                           2 (3%)                                                          
      Luteoma                                                                                              1 (2%)                   
   Uterus                                             (61)         (60)         (60)         (60)         (61)                      
      Adenoma                                          1 (2%)                                                                       
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                  1 (2%)       1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Ovary               1 (2%)                                                                       
      Histiocytic Sarcoma                                           2 (3%)                                                          
      Neoplasm NOS                                                  1 (2%)                                                          
      Polyp Stromal                                    1 (2%)       1 (2%)                                                          

                                                             Page   3                                                               
NTP Experiment-Test: 05121-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Sarcoma Stromal                                  1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (61)         (60)         (60)         (60)         (61)                      
      Hemangiosarcoma                                                                                      1 (2%)                   
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
   Lymph Node                                         (6)          (3)          (5)          (4)          (3)                       
      Bronchial, Carcinoma, Metastatic, Harderian                                                                                   
          Gland                                                                               1 (25%)                               
      Bronchial, Carcinoma, Metastatic, Liver          1 (17%)                                                                      
      Bronchial, Hepatocholangiocarcinoma,                                                                                          
          Metastatic, Liver                            1 (17%)                                                                      
      Bronchial, Histiocytic Sarcoma                                1 (33%)                                                         
      Mediastinal, Carcinoma, Metastatic, Liver        1 (17%)                                                                      
      Mediastinal, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                            1 (17%)                                                                      
      Mediastinal, Histiocytic Sarcoma                 1 (17%)      1 (33%)                                1 (33%)                  
   Lymph Node, Mandibular                             (59)         (57)         (55)         (58)         (61)                      
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node, Mesenteric                             (60)         (57)         (56)         (59)         (58)                      
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Spleen                                             (61)         (60)         (60)         (60)         (61)                      
      Hemangiosarcoma                                  1 (2%)       1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)       1 (2%)       1 (2%)                    1 (2%)                   
   Thymus                                             (57)         (53)         (53)         (56)         (55)                      
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Mast Cell Tumor Malignant                                                                            1 (2%)                   
      Mediastinum, Rhabdomyosarcoma, Metastatic,                                                                                    
           Skeletal Muscle                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (61)         (60)         (60)         (60)         (61)                      
      Squamous Cell Carcinoma                                                                              1 (2%)                   
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                    1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 05121-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (61)         (60)         (60)         (60)         (61)                      
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
   Skeletal Muscle                                    (1)                                    (1)                                    
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (100%)                                                                     
      Rhabdomyosarcoma                                                                        1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (61)         (60)         (60)         (60)         (61)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (61)         (60)         (60)         (60)         (61)                      
      Alveolar/Bronchiolar Adenoma                     3 (5%)       2 (3%)       4 (7%)       1 (2%)       2 (3%)                   
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)       3 (5%)       1 (2%)       1 (2%)                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                 1 (2%)                                
      Carcinoma, Metastatic, Liver                     1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Ovary               1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                    2 (3%)       5 (8%)       1 (2%)                   
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)       2 (3%)                                                          
      Mediastinum, Hemangiosarcoma                                  1 (2%)                                                          
   Nose                                               (61)         (60)         (60)         (60)         (61)                      
      Histiocytic Sarcoma                                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (18)         (10)         (15)         (16)         (16)                      
      Adenoma                                          1 (6%)       3 (30%)      3 (20%)      2 (13%)      1 (6%)                   
      Carcinoma                                        2 (11%)                   1 (7%)       1 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (61)         (60)         (60)         (60)         (61)                      
      Carcinoma, Metastatic, Liver                     1 (2%)                                                                       
      Hepatocholangiocarcinoma, Metastatic, Liver      1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
   Urinary Bladder                                    (60)         (60)         (58)         (59)         (61)                      

                                                             Page   5                                                               
NTP Experiment-Test: 05121-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(61)        *(60)        *(60)        *(60)        *(61)                      
      Histiocytic Sarcoma                              1 (2%)       4 (7%)       2 (3%)                    1 (2%)                   
      Lymphoma Malignant Lymphocytic                   2 (3%)       1 (2%)       3 (5%)       2 (3%)       4 (7%)                   
      Lymphoma Malignant Mixed                         7 (11%)      5 (8%)       5 (8%)       6 (10%)      3 (5%)                   
      Lymphoma Malignant Undifferentiated Cell                                                1 (2%)                                
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   6                                                               
NTP Experiment-Test: 05121-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            41          28          36          35          30                           
     Total Primary Neoplasms                           64          35          58          45          36                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 25          14          25          21          19                           
     Total Benign Neoplasms                            33          17          34          22          20                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          16          22          21          14                           
     Total Malignant Neoplasms                         31          17          24          23          16                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5                       2           7           1                           
     Total Metastatic Neoplasm                         19                       2           8           1                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   7                                                               
NTP Experiment-Test: 05121-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          70           60           70           70           70                        

  Scheduled Sacrifice                                 10           10           10           10           10                        
  Early Deaths                                                                                                                      
    Natural Death                                      6            6            4            5            2                        
    Moribund Sacrifice                                 4            2            7            4            7                        
    Dosing Accident                                                 1                                      1                        
    Accidently Killed                                                                         2            1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                40           41           39           39           39                        

  Animals Examined Microscopically                    60           60           60           60           60                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (60)         (60)         (60)         (60)         (60)                      
      Adenoma                                          1 (2%)                                                                       
   Intestine Small, Jejunum                           (60)         (60)         (60)         (59)         (60)                      
      Carcinoma                                                                               1 (2%)                                
   Intestine Small, Ileum                             (59)         (60)         (59)         (60)         (58)                      
   Liver                                              (60)         (60)         (60)         (60)         (60)                      
      Carcinoma, Multiple                                                                     1 (2%)                                
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                                                         3 (5%)                                
      Hemangiosarcoma, Multiple                                                               1 (2%)                                
      Hemangiosarcoma, Metastatic, Skin                1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen                           1 (2%)       1 (2%)                                             
      Hepatoblastoma                                                             1 (2%)                                             
      Hepatocellular Carcinoma                         6 (10%)      4 (7%)      13 (22%)      5 (8%)       8 (13%)                  
      Hepatocellular Carcinoma, Multiple                            1 (2%)       2 (3%)                                             
      Hepatocellular Adenoma                          11 (18%)      5 (8%)      20 (33%)      7 (12%)      8 (13%)                  
      Hepatocellular Adenoma, Multiple                17 (28%)      1 (2%)       5 (8%)       3 (5%)                                
      Hepatocholangiocarcinoma                                      1 (2%)                                                          
      Histiocytic Sarcoma                              3 (5%)                                              1 (2%)                   
      Ito Cell Tumor NOS, Multiple                     1 (2%)                                                                       
      Hepatocyte, Hepatocellular Adenoma                                         1 (2%)                                             
   Mesentery                                          (5)          (1)          (3)          (3)          (2)                       
      Hemangiosarcoma                                                            1 (33%)                                            
      Histiocytic Sarcoma                                                                                  1 (50%)                  
   Pancreas                                           (60)         (60)         (60)         (60)         (60)                      
   Stomach, Forestomach                               (60)         (60)         (60)         (60)         (60)                      
      Mast Cell Tumor Benign                                        1 (2%)                                                          
      Mast Cell Tumor Malignant                                                  1 (2%)                                             
      Squamous Cell Papilloma                                       2 (3%)                    1 (2%)                                

                                                             Page   8                                                               
NTP Experiment-Test: 05121-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Tooth                                              (14)                      (4)          (5)          (2)                       
      Odontoma                                         1 (7%)                    1 (25%)      2 (40%)      1 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)         (60)                      
      Hemangiosarcoma, Metastatic, Spleen                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)         (60)                      
      Adenoma                                          3 (5%)                                 1 (2%)       1 (2%)                   
   Pituitary Gland                                    (58)         (58)         (56)         (55)         (53)                      
      Pars Distalis, Adenoma                                                                               1 (2%)                   
      Pars Intermedia, Adenoma                         1 (2%)       1 (2%)                    1 (2%)                                
   Thyroid Gland                                      (60)         (60)         (60)         (60)         (60)                      
      Follicular Cell, Adenoma                                      1 (2%)       1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)         (60)                      
      Hemangiosarcoma, Metastatic, Bone Marrow                      1 (2%)                                                          
   Preputial Gland                                    (60)         (60)         (60)         (59)         (60)                      
      Sarcoma                                                                                              1 (2%)                   
   Seminal Vesicle                                    (60)         (60)         (60)         (60)         (60)                      
      Adenoma                                                                    1 (2%)                                             
   Testes                                             (60)         (60)         (60)         (60)         (60)                      
      Interstitial Cell, Adenoma                                                 1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)         (60)                      
      Hemangiosarcoma                                               1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Liver                                                      1 (2%)                                
      Hemangiosarcoma, Metastatic, Skin                1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen                           1 (2%)                                                          
   Lymph Node                                         (2)          (1)                       (2)          (3)                       
      Bronchial, Carcinoma, Metastatic, Liver                                                 1 (50%)                               

                                                             Page   9                                                               
NTP Experiment-Test: 05121-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Mediastinal, Carcinoma, Metastatic, Liver                                               1 (50%)                               
      Mediastinal, Histiocytic Sarcoma                                                                     1 (33%)                  
   Lymph Node, Mandibular                             (59)         (59)         (58)         (57)         (56)                      
   Lymph Node, Mesenteric                             (58)         (53)         (56)         (56)         (57)                      
      Carcinoma, Metastatic, Liver                                                            1 (2%)                                
      Hemangiosarcoma, Metastatic, Spleen                                                     1 (2%)                                
      Histiocytic Sarcoma                              3 (5%)                                              1 (2%)                   
   Spleen                                             (60)         (60)         (60)         (60)         (60)                      
      Hemangiosarcoma                                               1 (2%)                    1 (2%)                                
      Hemangiosarcoma, Multiple                                                  1 (2%)                                             
      Hemangiosarcoma, Metastatic, Liver                                                      1 (2%)                                
      Hemangiosarcoma, Metastatic, Skin                1 (2%)                                                                       
      Histiocytic Sarcoma                              2 (3%)                                              1 (2%)                   
   Thymus                                             (51)         (55)         (54)         (50)         (50)                      
      Carcinoma, Metastatic, Liver                                                            1 (2%)                                
      Mediastinum, Hemangioma                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (60)         (60)         (60)                      
      Mast Cell Tumor Malignant                                                  1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)         (60)                      
      Alveolar/Bronchiolar Adenoma                    13 (22%)     10 (17%)      7 (12%)      7 (12%)      6 (10%)                  
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       1 (2%)                    2 (3%)       1 (2%)                   
      Alveolar/Bronchiolar Carcinoma                   2 (3%)       1 (2%)       4 (7%)       1 (2%)       2 (3%)                   
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)                                                                       
      Carcinoma, Metastatic, Harderian Gland                                     2 (3%)                                             
      Carcinoma, Metastatic, Liver                                                            1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      3 (5%)       2 (3%)       3 (5%)       1 (2%)       3 (5%)                   
      Histiocytic Sarcoma                              1 (2%)                                              1 (2%)                   
   Nose                                               (60)         (60)         (60)         (60)         (60)                      

                                                             Page  10                                                               
NTP Experiment-Test: 05121-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Mast Cell Tumor Malignant                                                  2 (3%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (20)         (18)         (20)         (21)         (16)                      
      Adenoma                                          3 (15%)      1 (6%)       1 (5%)       1 (5%)       2 (13%)                  
      Carcinoma                                                                  4 (20%)      1 (5%)       1 (6%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)         (60)                      
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Artery, Hepatocellular Carcinoma, Metastatic,                                                                                 
           Liver                                                                                           1 (2%)                   
      Renal Tubule, Adenoma                                                                   1 (2%)                                
      Renal Tubule, Carcinoma                          2 (3%)                                                                       
   Urinary Bladder                                    (60)         (60)         (60)         (60)         (59)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)        *(60)                      
      Histiocytic Sarcoma                              3 (5%)                                              1 (2%)                   
      Leukemia Lymphocytic                             1 (2%)                                 1 (2%)       1 (2%)                   
      Lymphoma Malignant Lymphocytic                   1 (2%)                                 1 (2%)       3 (5%)                   
      Lymphoma Malignant Mixed                         3 (5%)       3 (5%)       2 (3%)       1 (2%)                                
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  11                                                               
NTP Experiment-Test: 05121-07  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 22:04:19  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/KG      0 MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                     
                                                                FEED RTD                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          26          45          32          31                           
     Total Primary Neoplasms                           73          36          70          44          39                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 40          20          32          22          19                           
     Total Benign Neoplasms                            52          24          38          27          21                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              17          11          25          16          16                           
     Total Malignant Neoplasms                         20          12          32          17          18                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           4           5           4           3                           
     Total Metastatic Neoplasm                          6           5           6          10           4                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  12                                                               
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