NTP Experiment-Test: 05121-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 04/03/96
Route: GAVAGE Time: 21:10:36
Facility: Battelle Columbus Laboratory
Chemical CAS #: 6533-68-2
Lock Date: 05/14/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05121-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 04/03/96
Route: GAVAGE Time: 21:10:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE O MG/KG 1 MG/KG 5 MG/KG 25 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund Sacrifice 13 10 6 7
Natural Death 3 15 16 16
Dosing Accident 2 2 5
Accidently Killed 16
Survivors
Terminal Sacrifice 34 17 26 22
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (60) (59) (57) (57)
Parasite Metazoan 2 (3%) 4 (7%) 2 (4%) 5 (9%)
Intestine Large, Rectum (60) (59) (57) (57)
Parasite Metazoan 7 (12%) 2 (3%) 4 (7%)
Intestine Small, Duodenum (60) (60) (60) (59)
Inflammation, Chronic 1 (2%)
Intestine Small, Jejunum (59) (56) (57) (56)
Inflammation, Chronic 1 (2%)
Liver (60) (60) (60) (60)
Basophilic Focus 22 (37%) 11 (18%) 21 (35%) 23 (38%)
Clear Cell Focus 1 (2%) 1 (2%)
Eosinophilic Focus 3 (5%) 4 (7%) 4 (7%) 5 (8%)
Fatty Change 2 (3%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 14 (23%) 9 (15%) 6 (10%) 11 (18%)
Hyperplasia, Adenomatous 1 (2%)
Inflammation, Acute, Focal 1 (2%)
Inflammation, Granulomatous 1 (2%)
Mixed Cell Focus 1 (2%)
Necrosis 1 (2%)
Bile Duct, Inflammation, Chronic 1 (2%)
Serosa, Fibrosis 1 (2%)
Mesentery (1) (3) (3) (2)
Fat, Necrosis 1 (100%) 3 (100%) 2 (67%) 2 (100%)
Lymphatic, Cyst 1 (33%)
Pancreas (60) (60) (60) (60)
Acinus, Atrophy 16 (27%) 7 (12%) 8 (13%) 6 (10%)
Artery, Inflammation, Chronic 1 (2%)
Duct, Concretion 1 (2%)
Salivary Glands (60) (60) (60) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05121-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 04/03/96
Route: GAVAGE Time: 21:10:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE O MG/KG 1 MG/KG 5 MG/KG 25 MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Inflammation, Chronic 1 (2%)
Inflammation, Subacute 1 (2%)
Stomach, Forestomach (60) (60) (60) (58)
Hyperkeratosis 1 (2%)
Ulcer 2 (3%) 1 (2%) 1 (2%)
Stomach, Glandular (60) (60) (60) (59)
Ulcer 3 (5%) 1 (2%) 1 (2%)
Artery, Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (60) (60) (60) (59)
Inflammation, Granulomatous 1 (2%)
Mineralization 1 (2%)
Heart (60) (60) (60) (60)
Atrium, Thrombosis 1 (2%) 1 (2%) 1 (2%)
Myocardium, Degeneration 30 (50%) 17 (28%) 31 (52%) 24 (40%)
Myocardium, Mineralization 1 (2%)
Valve, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60)
Degeneration 1 (2%)
Hyperplasia 11 (18%) 5 (8%) 6 (10%) 4 (7%)
Adrenal Medulla (60) (60) (60) (60)
Hyperplasia 2 (3%) 1 (2%) 1 (2%)
Bilateral, Hyperplasia 1 (2%)
Pituitary Gland (60) (60) (60) (60)
Cyst 39 (65%) 28 (47%) 37 (62%) 31 (52%)
Pigmentation, Hemosiderin 1 (2%)
Pars Distalis, Angiectasis 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 16 (27%) 11 (18%) 16 (27%) 17 (28%)
Thyroid Gland (60) (60) (60) (60)
C-Cell, Hyperplasia 5 (8%) 1 (2%) 2 (3%) 2 (3%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05121-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 04/03/96
Route: GAVAGE Time: 21:10:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE O MG/KG 1 MG/KG 5 MG/KG 25 MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (59) (60) (58) (60)
Ectasia 5 (8%) 1 (2%)
Hyperplasia 2 (3%) 1 (2%)
Inflammation, Suppurative 2 (3%) 2 (3%) 1 (2%)
Ovary (60) (60) (60) (60)
Cyst 1 (2%) 2 (3%) 1 (2%) 3 (5%)
Uterus (60) (60) (60) (60)
Decidual Reaction 1 (2%)
Dilatation 1 (2%)
Hyperplasia, Cystic 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Vagina (2) (1)
Infiltration Cellular, Polymorphonuclear 1 (50%)
Epithelium, Vacuolization Cytoplasmic 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Inflammation, Granulomatous 1 (2%)
Myelofibrosis 1 (2%)
Myelostromal Proliferation 1 (2%)
Lymph Node (2) (2) (2)
Renal, Pigmentation, Hemosiderin 1 (50%)
Lymph Node, Mandibular (60) (60) (60) (60)
Inflammation, Chronic 1 (2%)
Lymph Node, Mesenteric (60) (59) (60) (60)
Inflammation, Subacute 1 (2%)
Spleen (60) (60) (60) (60)
Fibrosis 2 (3%) 2 (3%) 2 (3%)
Hematopoietic Cell Proliferation 1 (2%) 4 (7%) 1 (2%) 2 (3%)
Necrosis 1 (2%) 1 (2%)
Lymphoid Follicle, Atrophy 1 (2%) 2 (3%)
Red Pulp, Atrophy 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (60) (60) (58)
Edema 1 (2%)
Hyperplasia, Cystic 2 (3%) 1 (2%) 1 (2%)
Inflammation 1 (2%)
Skin (60) (60) (60) (60)
Acanthosis 1 (2%)
Hyperkeratosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05121-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 04/03/96
Route: GAVAGE Time: 21:10:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE O MG/KG 1 MG/KG 5 MG/KG 25 MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Ulcer 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Osteopetrosis 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Erythrophagocytosis 1 (2%)
Foreign Body 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Infiltration Cellular, Mononuclear Cell 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 2 (3%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Subacute 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (3%) 2 (3%) 4 (7%) 1 (2%)
Alveolus, Edema 1 (2%)
Bronchus, Inflammation, Acute 1 (2%)
Nose (60) (60) (60) (60)
Exudate 1 (2%)
Inflammation, Suppurative 2 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2) (1)
External Ear, Ulcer 1 (100%)
Eye (2) (3) (2)
Inflammation, Chronic 1 (33%)
Anterior Chamber, Inflammation 1 (50%)
Cornea, Necrosis 1 (50%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05121-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 04/03/96
Route: GAVAGE Time: 21:10:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE O MG/KG 1 MG/KG 5 MG/KG 25 MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Cyst 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hydronephrosis 1 (2%)
Infarct 1 (2%)
Nephropathy 35 (58%) 22 (37%) 29 (48%) 14 (23%)
Pelvis, Inflammation, Chronic 1 (2%)
Urinary Bladder (60) (60) (59) (60)
Calculus Gross Observation 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05121-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 04/03/96
Route: GAVAGE Time: 21:10:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE O MG/KG 1 MG/KG 5 MG/KG 25 MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Scheduled Sacrifice 10 10 10 10
Early Deaths
Moribund Sacrifice 23 30 20 17
Natural Death 5 4 7 4
Dosing Accident 2 2 1 1
Survivors
Terminal Sacrifice 20 14 22 28
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (60) (60) (60)
Inflammation, Chronic 1 (2%)
Ulcer 1 (2%)
Periesophageal Tissue, Inflammation, Chronic 1 (2%)
Intestine Large, Colon (60) (60) (60) (60)
Parasite Metazoan 4 (7%) 2 (3%) 2 (3%)
Ulcer 1 (2%)
Intestine Large, Rectum (59) (60) (60) (60)
Parasite Metazoan 9 (15%) 1 (2%) 4 (7%) 3 (5%)
Intestine Large, Cecum (60) (60) (59) (60)
Parasite Metazoan 1 (2%)
Ulcer 1 (2%) 1 (2%)
Intestine Small, Jejunum (60) (60) (59) (59)
Inflammation, Chronic 1 (2%)
Ulcer 1 (2%)
Intestine Small, Ileum (60) (60) (60) (59)
Inflammation, Chronic 1 (2%)
Liver (60) (60) (60) (60)
Basophilic Focus 4 (7%) 5 (8%) 6 (10%) 5 (8%)
Clear Cell Focus 1 (2%) 1 (2%) 2 (3%)
Cyst 1 (2%) 1 (2%)
Degeneration, Cystic 9 (15%) 3 (5%) 4 (7%)
Eosinophilic Focus 2 (3%) 3 (5%) 2 (3%) 4 (7%)
Fatty Change 2 (3%) 5 (8%) 5 (8%)
Hepatodiaphragmatic Nodule 4 (7%) 5 (8%) 7 (12%) 4 (7%)
Hyperplasia 1 (2%)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%)
Mixed Cell Focus 2 (3%) 2 (3%)
Necrosis 1 (2%) 1 (2%) 1 (2%)
Centrilobular, Degeneration 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05121-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 04/03/96
Route: GAVAGE Time: 21:10:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE O MG/KG 1 MG/KG 5 MG/KG 25 MG/KG
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Portal, Degeneration 1 (2%)
Sinusoid, Congestion, Focal 1 (2%)
Mesentery (7) (15) (24) (15)
Inflammation, Suppurative 1 (7%)
Artery, Thrombosis 1 (14%)
Fat, Inflammation 1 (7%)
Fat, Necrosis 6 (86%) 14 (93%) 19 (79%) 13 (87%)
Lymphatic, Cyst 1 (14%)
Pancreas (60) (60) (60) (60)
Acinus, Atrophy 20 (33%) 17 (28%) 10 (17%) 14 (23%)
Arteriole, Inflammation, Chronic 1 (2%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Stomach, Forestomach (60) (60) (60) (60)
Hyperkeratosis 1 (2%)
Inflammation, Chronic 1 (2%)
Ulcer 3 (5%) 6 (10%) 4 (7%) 7 (12%)
Stomach, Glandular (60) (60) (60) (60)
Erosion 1 (2%)
Mineralization 1 (2%) 1 (2%)
Ulcer 8 (13%) 6 (10%) 2 (3%)
Tongue (1)
Foreign Body 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Atrium, Thrombosis 3 (5%) 2 (3%) 5 (8%) 3 (5%)
Myocardium, Degeneration 48 (80%) 51 (85%) 48 (80%) 43 (72%)
Valve, Inflammation, Chronic 1 (2%)
Valve, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60)
Hyperplasia 8 (13%) 10 (17%) 12 (20%) 7 (12%)
Adrenal Medulla (60) (60) (60) (60)
Hyperplasia 2 (3%) 5 (8%) 4 (7%) 2 (3%)
Necrosis 1 (2%)
Islets, Pancreatic (60) (60) (60) (60)
Hyperplasia 2 (3%)
Parathyroid Gland (55) (55) (55) (59)
Hyperplasia 1 (2%)
Pituitary Gland (59) (58) (60) (60)
Angiectasis 1 (2%)
Cyst 5 (8%) 8 (14%) 5 (8%) 7 (12%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05121-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 04/03/96
Route: GAVAGE Time: 21:10:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE O MG/KG 1 MG/KG 5 MG/KG 25 MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hyperplasia 19 (32%) 19 (33%) 12 (20%) 21 (35%)
Pars Intermedia, Hyperplasia, Tubular 1 (2%)
Thyroid Gland (60) (60) (60) (60)
C-Cell, Hyperplasia 3 (5%) 3 (5%) 6 (10%) 4 (7%)
C-Cell, Infiltration Cellular 1 (2%)
Follicle, Dilatation 2 (3%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (60) (60) (58) (60)
Ectasia 1 (2%) 2 (3%)
Fibrosis 1 (2%)
Hyperplasia 1 (2%) 2 (3%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 6 (10%) 2 (3%) 4 (7%) 3 (5%)
Prostate (60) (60) (60) (60)
Inflammation 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Seminal Vesicle (60) (60) (60) (60)
Fibrosis 1 (2%)
Testes (60) (60) (60) (60)
Atrophy 1 (2%)
Germinal Epithelium, Atrophy 2 (3%) 4 (7%) 6 (10%) 3 (5%)
Interstitial Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60)
Fibrosis 1 (2%)
Hyperplasia 1 (2%)
Lymph Node (5) (8) (5) (9)
Lumbar, Angiectasis 1 (11%)
Mediastinal, Angiectasis 1 (13%)
Mediastinal, Pigmentation, Hemosiderin 1 (20%)
Renal, Pigmentation, Hemosiderin 1 (11%)
Lymph Node, Mandibular (60) (59) (60) (58)
Hemorrhage 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Lymph Node, Mesenteric (59) (60) (60) (60)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05121-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 04/03/96
Route: GAVAGE Time: 21:10:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE O MG/KG 1 MG/KG 5 MG/KG 25 MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Congestion 1 (2%)
Fibrosis 1 (2%)
Inflammation, Suppurative 1 (2%)
Spleen (60) (60) (60) (60)
Fibrosis 11 (18%) 11 (18%) 6 (10%) 8 (13%)
Hematopoietic Cell Proliferation 3 (5%) 3 (5%) 4 (7%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Necrosis 1 (2%)
Thymus (55) (55) (58) (57)
Atrophy 2 (4%) 1 (2%)
Congestion 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (55) (57) (57) (56)
Hyperplasia, Cystic 2 (4%) 1 (2%) 1 (2%)
Lymphatic, Ectasia 1 (2%)
Skin (60) (60) (60) (59)
Hyperkeratosis 2 (3%)
Hyperplasia, Basal Cell 1 (2%)
Inflammation, Acute 1 (2%)
Ulcer 1 (2%)
Dermis, Fibrosis, Focal 1 (2%)
Hair Follicle, Atrophy, Focal 1 (2%)
Subcutaneous Tissue, Edema 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60)
Fibrous Osteodystrophy 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Hypothalamus, Hemorrhage 1 (2%)
Medulla, Gliosis 1 (2%)
Ventricle, Hydrocephalus 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05121-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC SCOPOLAMINE HYDROBROMIDE TRIHYDRATE Date: 04/03/96
Route: GAVAGE Time: 21:10:36
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE O MG/KG 1 MG/KG 5 MG/KG 25 MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Ectopic Tissue 1 (2%)
Foreign Body 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Inflammation, Granulomatous 3 (5%) 1 (2%)
Inflammation, Subacute 1 (2%) 1 (2%) 3 (5%)
Alveolar Epithelium, Hyperplasia 1 (2%) 2 (3%) 1 (2%) 1 (2%)
Alveolus, Edema 1 (2%)
Interstitium, Inflammation 1 (2%)
Pleura, Inflammation, Chronic 1 (2%)
Nose (60) (60) (60) (60)
Foreign Body 1 (2%)
Inflammation, Suppurative 2 (3%) 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (6) (1) (2)
Inflammation, Chronic 3 (50%)
External Ear, Hyperkeratosis 2 (33%)
External Ear, Inflammation, Chronic 1 (50%)
Eye (1) (1) (1) (1)
Degeneration 1 (100%)
Lens, Cataract 1 (100%) 1 (100%)
Harderian Gland (1) (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Cyst 1 (2%)
Nephropathy 57 (95%) 54 (90%) 57 (95%) 50 (83%)
Renal Tubule, Pigmentation, Hemosiderin 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (60) (60) (60) (60)
Inflammation, Acute 1 (2%)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------