TDMS Study 05122-05 Pathology Tables
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
Core Animals
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 010101970
Lock Date: 02/03/93
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25023 Missing
25019 Moribund Sacrifice 25020 Natural Death
25026 Other 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 6| 5| 7| 7| 5| 7| 5| 6| 6| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 2| 9| 3| 3| 5| 8| 3| 3| 0| 3| 3| 4| 6| 3| 6| 9| 9| 3| 3| 3| 2| 3| 1|
| 9| 7| 2| 1| 2| 1| 8| 9| 2| 0| 3| 1| 8| 0| 6| 1| 3| 0| 6| 0| 2| 1| 1| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|
| 4| 6| 9| 0| 1| 2| 4| 6| 7| 8| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pancreas | X |
__________________________________________________________________________|
Intestine Large, Rectum | I + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pancreas | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pancreas | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pancreas | X |
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Oral Mucosa | + |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pancreas | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pancreas | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + M + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 6| 5| 7| 7| 5| 7| 5| 6| 6| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 2| 9| 3| 3| 5| 8| 3| 3| 0| 3| 3| 4| 6| 3| 6| 9| 9| 3| 3| 3| 2| 3| 1|
| 9| 7| 2| 1| 2| 1| 8| 9| 2| 0| 3| 1| 8| 0| 6| 1| 3| 0| 6| 0| 2| 1| 1| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|
| 4| 6| 9| 0| 1| 2| 4| 6| 7| 8| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + + + |
Mediastinum, Leukemia Mononuclear | X X X |
Pericardial, Carcinoma, Metastatic, | |
Pancreas | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | X |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pancreas | X |
Polyp Stromal | X X X |
__________________________________________________________________________|
Vagina | + |
Carcinoma, Metastatic, Pancreas | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Carcinoma, Metastatic, | |
Pancreas | X |
Iliac, Leukemia Mononuclear | X X |
Inguinal, Leukemia Mononuclear | X X |
Pancreatic, Carcinoma, Metastatic, | |
Pancreas | X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + M + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pancreas | X |
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 6| 5| 7| 7| 5| 7| 5| 6| 6| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 2| 9| 3| 3| 5| 8| 3| 3| 0| 3| 3| 4| 6| 3| 6| 9| 9| 3| 3| 3| 2| 3| 1|
| 9| 7| 2| 1| 2| 1| 8| 9| 2| 0| 3| 1| 8| 0| 6| 1| 3| 0| 6| 0| 2| 1| 1| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|
| 4| 6| 9| 0| 1| 2| 4| 6| 7| 8| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + I + + + + + + + + + + + + + + I +|
Carcinoma, Metastatic, Pancreas | X |
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pancreas | X |
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + I + + + + + + + + + + + + + + + M + M|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Adenoma | X |
Fibroadenoma | X X X X X X X |
Fibroadenoma, Multiple | X X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + I + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pancreas | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 7| 6| 5| 7| 7| 5| 7| 5| 6| 6| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 7| 2| 9| 3| 3| 5| 8| 3| 3| 0| 3| 3| 4| 6| 3| 6| 9| 9| 3| 3| 3| 2| 3| 1|
| 9| 7| 2| 1| 2| 1| 8| 9| 2| 0| 3| 1| 8| 0| 6| 1| 3| 0| 6| 0| 2| 1| 1| 2| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|
| 4| 6| 9| 0| 1| 2| 4| 6| 7| 8| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 7| 4| 5| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 2| 4| 6| 2| 4| 3| 8| 2| 3| 3| 9| 8| 3| 3| 8| 8| 3| 4| 4| 1| 3| 2| 3|
| 3| 3| 7| 3| 9| 9| 3| 2| 6| 1| 2| 2| 2| 4| 6| 0| 3| 8| 1| 6| 2| 3| 2| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 1| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +|
Carcinoma, Metastatic, Pancreas | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + A + + + + +|
Carcinoma, Metastatic, Pancreas | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +|
Carcinoma, Metastatic, Pancreas | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + A + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + A + + + + +|
Carcinoma, Metastatic, Pancreas | |
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Oral Mucosa | + + |
Squamous Cell Carcinoma | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +|
Carcinoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A + + + + +|
Carcinoma, Metastatic, Pancreas | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +|
Carcinoma, Metastatic, Pancreas | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 7| 4| 5| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 2| 4| 6| 2| 4| 3| 8| 2| 3| 3| 9| 8| 3| 3| 8| 8| 3| 4| 4| 1| 3| 2| 3|
| 3| 3| 7| 3| 9| 9| 3| 2| 6| 1| 2| 2| 2| 4| 6| 0| 3| 8| 1| 6| 2| 3| 2| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 1| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Mediastinum, Leukemia Mononuclear | X |
Pericardial, Carcinoma, Metastatic, | |
Pancreas | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + A + + + + +|
Adenoma | X X X X|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + A + + + + +|
Granulosa Cell Tumor Benign | |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + A + + + + +|
Carcinoma, Metastatic, Pancreas | |
Polyp Stromal | X |
__________________________________________________________________________|
Vagina | |
Carcinoma, Metastatic, Pancreas | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Carcinoma, Metastatic, | |
Pancreas | |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | |
Pancreatic, Carcinoma, Metastatic, | |
Pancreas | |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + M + + + M +|
Carcinoma, Metastatic, Pancreas | |
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X X X X X |
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 7| 4| 5| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 2| 4| 6| 2| 4| 3| 8| 2| 3| 3| 9| 8| 3| 3| 8| 8| 3| 4| 4| 1| 3| 2| 3|
| 3| 3| 7| 3| 9| 9| 3| 2| 6| 1| 2| 2| 2| 4| 6| 0| 3| 8| 1| 6| 2| 3| 2| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 1| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + M + + + + + + + + A M + + + +|
Carcinoma, Metastatic, Pancreas | |
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + A + + + + +|
Carcinoma, Metastatic, Pancreas | |
Leukemia Mononuclear | X X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + A + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Adenocarcinoma | X X X |
Adenoma | |
Fibroadenoma | X X X X X X |
Fibroadenoma, Multiple | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Squamous Cell Carcinoma | |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + A + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + A + + + + +|
Carcinoma, Metastatic, Pancreas | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 7| 4| 5| 7| 7| 7| 7|
DAY ON TEST | 4| 4| 2| 4| 6| 2| 4| 3| 8| 2| 3| 3| 9| 8| 3| 3| 8| 8| 3| 4| 4| 1| 3| 2| 3|
| 3| 3| 7| 3| 9| 9| 3| 2| 6| 1| 2| 2| 2| 4| 6| 0| 3| 8| 1| 6| 2| 3| 2| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
| 9| 1| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| | |
DAY ON TEST | 6| 3| 2| | |
| 6| 0| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0.0MG/M3 | 3| 3| 4| | L |
| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 52 |
Carcinoma, Metastatic, Pancreas | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 51 |
Carcinoma, Metastatic, Pancreas | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 52 |
Carcinoma, Metastatic, Pancreas | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + | 52 |
Carcinoma, Metastatic, Pancreas | | 1 |
Leukemia Mononuclear | | 23 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | | 3 |
Squamous Cell Carcinoma | | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + | 52 |
Carcinoma | | 1 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 52 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 52 |
Carcinoma, Metastatic, Pancreas | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 52 |
Carcinoma, Metastatic, Pancreas | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tooth | | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Leukemia Mononuclear | | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 52 |
Leukemia Mononuclear | | 6 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| | |
DAY ON TEST | 6| 3| 2| | |
| 6| 0| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0.0MG/M3 | 3| 3| 4| | L |
| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 5 |
Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 52 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 52 |
Leukemia Mononuclear | | 6 |
Pars Distalis, Adenoma | X | 22 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 52 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | | 1 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 6 |
Mediastinum, Leukemia Mononuclear | | 4 |
Pericardial, Carcinoma, Metastatic, | | |
Pancreas | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + | 51 |
Adenoma | | 4 |
__________________________________________________________________________|____________|
Ovary | + + + | 52 |
Granulosa Cell Tumor Benign | | 1 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Uterus | + + + | 52 |
Carcinoma, Metastatic, Pancreas | | 1 |
Polyp Stromal | | 4 |
__________________________________________________________________________|____________|
Vagina | | 1 |
Carcinoma, Metastatic, Pancreas | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 52 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Lymph Node | | 8 |
Iliac, Carcinoma, Metastatic, | | |
Pancreas | | 1 |
Iliac, Leukemia Mononuclear | | 3 |
Inguinal, Leukemia Mononuclear | | 2 |
Pancreatic, Carcinoma, Metastatic, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| | |
DAY ON TEST | 6| 3| 2| | |
| 6| 0| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0.0MG/M3 | 3| 3| 4| | L |
| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreas | | 1 |
Pancreatic, Leukemia Mononuclear | | 4 |
Renal, Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 50 |
Carcinoma, Metastatic, Pancreas | | 1 |
Leukemia Mononuclear | | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 52 |
Leukemia Mononuclear | | 12 |
Squamous Cell Carcinoma, Metastatic, | | |
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 52 |
Leukemia Mononuclear | | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 48 |
Carcinoma, Metastatic, Pancreas | | 1 |
Leukemia Mononuclear | | 13 |
__________________________________________________________________________|____________|
Spleen | + + + | 52 |
Carcinoma, Metastatic, Pancreas | | 1 |
Leukemia Mononuclear | | 25 |
__________________________________________________________________________|____________|
Thymus | + + + | 48 |
Leukemia Mononuclear | | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 52 |
Adenocarcinoma | | 4 |
Adenoma | | 1 |
Fibroadenoma | X | 14 |
Fibroadenoma, Multiple | | 3 |
__________________________________________________________________________|____________|
Skin | + + + | 53 |
Leukemia Mononuclear | | 1 |
Squamous Cell Carcinoma | X | 1 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 52 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 5| 7| 7| | |
DAY ON TEST | 6| 3| 2| | |
| 6| 0| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| | A |
0.0MG/M3 | 3| 3| 4| | L |
| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 51 |
__________________________________________________________________________|____________|
Lung | + + + | 52 |
Leukemia Mononuclear | | 15 |
__________________________________________________________________________|____________|
Nose | + + + | 51 |
__________________________________________________________________________|____________|
Trachea | + + + | 52 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 52 |
Carcinoma, Metastatic, Pancreas | | 1 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Leukemia Mononuclear | | 25 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 5| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 5| 6| 7| 7| 6|
DAY ON TEST | 4| 7| 2| 2| 4| 3| 9| 5| 7| 2| 3| 3| 2| 3| 3| 5| 3| 5| 2| 3| 8| 5| 0| 2| 6|
| 4| 8| 9| 7| 3| 2| 2| 6| 6| 9| 1| 2| 9| 6| 2| 9| 1| 7| 5| 0| 0| 8| 6| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
MG/M3 | 1| 3| 5| 6| 7| 8| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + I + + + + + + I + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lipoma | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Oral Mucosa | + |
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 5| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 5| 6| 7| 7| 6|
DAY ON TEST | 4| 7| 2| 2| 4| 3| 9| 5| 7| 2| 3| 3| 2| 3| 3| 5| 3| 5| 2| 3| 8| 5| 0| 2| 6|
| 4| 8| 9| 7| 3| 2| 2| 6| 6| 9| 1| 2| 9| 6| 2| 9| 1| 7| 5| 0| 0| 8| 6| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
MG/M3 | 1| 3| 5| 6| 7| 8| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Mediastinum, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X |
Schwannoma Malignant | X |
__________________________________________________________________________|
Vagina | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + I + M + + + + + + + + + + + + + + + + + + + M|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + A + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + A + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 5| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 5| 6| 7| 7| 6|
DAY ON TEST | 4| 7| 2| 2| 4| 3| 9| 5| 7| 2| 3| 3| 2| 3| 3| 5| 3| 5| 2| 3| 8| 5| 0| 2| 6|
| 4| 8| 9| 7| 3| 2| 2| 6| 6| 9| 1| 2| 9| 6| 2| 9| 1| 7| 5| 0| 0| 8| 6| 9| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
MG/M3 | 1| 3| 5| 6| 7| 8| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X X X X |
Fibroadenoma | X X X|
Fibroadenoma, Multiple | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Plasma Cell Tumor Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Cerebrum, Astrocytoma NOS | |
Meninges, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + A + + +|
Nasopharyngeal Duct, Leukemia | |
Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Retrobulbar, Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 4| 7| 5| 5| 5| 6| 6| 6| 5| 7| 7| 5| 6| 6| 3| 6| 6| 7| 5| 7|
DAY ON TEST | 0| 0| 2| 3| 6| 8| 2| 7| 3| 3| 0| 4| 9| 9| 2| 3| 5| 8| 1| 9| 4| 2| 3| 3| 3|
| 5| 7| 9| 0| 4| 9| 9| 3| 7| 7| 0| 4| 1| 6| 9| 1| 9| 2| 9| 2| 4| 0| 0| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|
MG/M3 | 7| 8| 9| 0| 1| 3| 4| 6| 7| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lipoma | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Oral Mucosa | + |
Squamous Cell Carcinoma | X |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + I + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 4| 7| 5| 5| 5| 6| 6| 6| 5| 7| 7| 5| 6| 6| 3| 6| 6| 7| 5| 7|
DAY ON TEST | 0| 0| 2| 3| 6| 8| 2| 7| 3| 3| 0| 4| 9| 9| 2| 3| 5| 8| 1| 9| 4| 2| 3| 3| 3|
| 5| 7| 9| 0| 4| 9| 9| 3| 7| 7| 0| 4| 1| 6| 9| 1| 9| 2| 9| 2| 4| 0| 0| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|
MG/M3 | 7| 8| 9| 0| 1| 3| 4| 6| 7| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | X X |
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
Mediastinum, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X|
Schwannoma Malignant | |
__________________________________________________________________________|
Vagina | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + M I + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 6| 4| 7| 5| 5| 5| 6| 6| 6| 5| 7| 7| 5| 6| 6| 3| 6| 6| 7| 5| 7|
DAY ON TEST | 0| 0| 2| 3| 6| 8| 2| 7| 3| 3| 0| 4| 9| 9| 2| 3| 5| 8| 1| 9| 4| 2| 3| 3| 3|
| 5| 7| 9| 0| 4| 9| 9| 3| 7| 7| 0| 4| 1| 6| 9| 1| 9| 2| 9| 2| 4| 0| 0| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 | 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|
MG/M3 | 7| 8| 9| 0| 1| 3| 4| 6| 7| 9| 1| 2| 3| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Fibroadenoma | X X X X X X X X X X X X X |
Fibroadenoma, Multiple | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Plasma Cell Tumor Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Cerebrum, Astrocytoma NOS | X |
Meninges, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasopharyngeal Duct, Leukemia | |
Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Retrobulbar, Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Papilloma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 5| 5| 6| | |
DAY ON TEST | 9| 5| 5| | |
| 6| 0| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.12 | 7| 7| 8| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
Lipoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A | 51 |
Fibrosarcoma | | 1 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Leukemia Mononuclear | X X | 24 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Oral Mucosa | | 2 |
Squamous Cell Carcinoma | | 1 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Leukemia Mononuclear | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Leukemia Mononuclear | | 3 |
Pheochromocytoma Benign | | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 5| 5| 6| | |
DAY ON TEST | 9| 5| 5| | |
| 6| 0| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.12 | 7| 7| 8| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 52 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Leukemia Mononuclear | X | 6 |
Pars Distalis, Adenoma | X | 24 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
C-Cell, Adenoma | | 2 |
Follicular Cell, Adenoma | | 1 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 4 |
Mediastinum, Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + | 52 |
Adenoma | | 4 |
Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Granulosa Cell Tumor Malignant | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Polyp Stromal | | 3 |
Schwannoma Malignant | | 1 |
__________________________________________________________________________|____________|
Vagina | + | 1 |
Schwannoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Lymph Node | + | 7 |
Iliac, Leukemia Mononuclear | | 2 |
Inguinal, Leukemia Mononuclear | | 2 |
Pancreatic, Leukemia Mononuclear | X | 4 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 52 |
Leukemia Mononuclear | X | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 52 |
Leukemia Mononuclear | X | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 5| 5| 6| | |
DAY ON TEST | 9| 5| 5| | |
| 6| 0| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.12 | 7| 7| 8| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Leukemia Mononuclear | X | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 50 |
Leukemia Mononuclear | X | 9 |
__________________________________________________________________________|____________|
Spleen | + + + | 52 |
Leukemia Mononuclear | X X | 25 |
__________________________________________________________________________|____________|
Thymus | + + + | 49 |
Leukemia Mononuclear | X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Adenocarcinoma | | 4 |
Fibroadenoma | | 16 |
Fibroadenoma, Multiple | | 2 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + + + | 53 |
Plasma Cell Tumor Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Leukemia Mononuclear | | 1 |
Cerebrum, Astrocytoma NOS | | 1 |
Meninges, Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 53 |
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Leukemia Mononuclear | X X | 19 |
__________________________________________________________________________|____________|
Nose | + + + | 52 |
Nasopharyngeal Duct, Leukemia | | |
Mononuclear | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Retrobulbar, Carcinoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 5| 5| 6| | |
DAY ON TEST | 9| 5| 5| | |
| 6| 0| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.12 | 7| 7| 8| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Leukemia Mononuclear | X X | 25 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 6| 7| 6| 4| 0| 7| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 6| 6|
DAY ON TEST | 0| 0| 4| 0| 4| 3| 4| 1| 7| 3| 1| 3| 2| 3| 6| 0| 2| 3| 2| 0| 3| 5| 4| 6| 6|
| 5| 6| 7| 3| 0| 1| 2| 7| 5| 1| 0| 1| 9| 0| 2| 0| 9| 0| 9| 8| 2| 5| 8| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
MG/M3 | 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | X |
Lipoma | |
__________________________________________________________________________|
Oral Mucosa | + + |
Squamous Cell Carcinoma | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Complex | X |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Pars Distalis, Adenoma | X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 6| 7| 6| 4| 0| 7| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 6| 6|
DAY ON TEST | 0| 0| 4| 0| 4| 3| 4| 1| 7| 3| 1| 3| 2| 3| 6| 0| 2| 3| 2| 0| 3| 5| 4| 6| 6|
| 5| 6| 7| 3| 0| 1| 2| 7| 5| 1| 0| 1| 9| 0| 2| 0| 9| 0| 9| 8| 2| 5| 8| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
MG/M3 | 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Mediastinum, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | X |
__________________________________________________________________________|
Vagina | |
Fibroma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Axillary, Leukemia Mononuclear | X X |
Deep Cervical, Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | X X X X |
Inguinal, Leukemia Mononuclear | X X X |
Pancreatic, Leukemia Mononuclear | X X X X |
Renal, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M M + + + + + + + + + + I M + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + I +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 6| 7| 6| 4| 0| 7| 6| 6| 6| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 6| 6| 6| 6|
DAY ON TEST | 0| 0| 4| 0| 4| 3| 4| 1| 7| 3| 1| 3| 2| 3| 6| 0| 2| 3| 2| 0| 3| 5| 4| 6| 6|
| 5| 6| 7| 3| 0| 1| 2| 7| 5| 1| 0| 1| 9| 0| 2| 0| 9| 0| 9| 8| 2| 5| 8| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
MG/M3 | 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Fibroadenoma | X X X |
Fibroadenoma, Multiple | X X|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma NOS | X |
Leukemia Mononuclear | X |
Meninges, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X|
Squamous Cell Carcinoma, Metastatic, | |
Uncertain Primary Site | |
Pleura, Leukemia Mononuclear | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Nasopharyngeal Duct, Leukemia | |
Mononuclear | X X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 1| 8| 6| 7| 4| 2| 3| 3| 2| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|
| 2| 2| 1| 5| 3| 2| 5| 8| 9| 1| 1| 9| 9| 0| 0| 1| 2| 0| 1| 1| 1| 1| 2| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
MG/M3 | 2| 3| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 9| 0| 1| 2| 6| 7| 8| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + I + + + + + + + + + + + + + + + + I + I +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | |
Lipoma | X |
__________________________________________________________________________|
Oral Mucosa | |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Complex | |
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 1| 8| 6| 7| 4| 2| 3| 3| 2| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|
| 2| 2| 1| 5| 3| 2| 5| 8| 9| 1| 1| 9| 9| 0| 0| 1| 2| 0| 1| 1| 1| 1| 2| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
MG/M3 | 2| 3| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 9| 0| 1| 2| 6| 7| 8| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | |
C-Cell, Adenoma | X X |
C-Cell, Carcinoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Mediastinum, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | X |
__________________________________________________________________________|
Vagina | + |
Fibroma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node | + + + + |
Axillary, Leukemia Mononuclear | X |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + M + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + I M I + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 1| 8| 6| 7| 4| 2| 3| 3| 2| 2| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|
| 2| 2| 1| 5| 3| 2| 5| 8| 9| 1| 1| 9| 9| 0| 0| 1| 2| 0| 1| 1| 1| 1| 2| 0| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.25 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
MG/M3 | 2| 3| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 9| 0| 1| 2| 6| 7| 8| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Fibroadenoma | X X X X |
Fibroadenoma, Multiple | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + M + + + + + + + + + + + + + + +|
Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma NOS | |
Leukemia Mononuclear | |
Meninges, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
Squamous Cell Carcinoma, Metastatic, | |
Uncertain Primary Site | X |
Pleura, Leukemia Mononuclear | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasopharyngeal Duct, Leukemia | |
Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| | |
DAY ON TEST | 9| 3| 3| 3| | |
| 7| 0| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| | A |
0.25 | 1| 1| 1| 2| | L |
MG/M3 | 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 53 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 53 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 52 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Liver | + + + + | 53 |
Leukemia Mononuclear | X X X | 32 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
Leukemia Mononuclear | | 1 |
Lipoma | | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | | 2 |
Squamous Cell Carcinoma | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 53 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 53 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 53 |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 53 |
Leukemia Mononuclear | | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 53 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 53 |
Leukemia Mononuclear | X | 4 |
Pheochromocytoma Complex | | 1 |
Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| | |
DAY ON TEST | 9| 3| 3| 3| | |
| 7| 0| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| | A |
0.25 | 1| 1| 1| 2| | L |
MG/M3 | 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 51 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 53 |
Leukemia Mononuclear | X | 15 |
Pars Distalis, Adenoma | | 24 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 53 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | | 4 |
C-Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Mediastinum, Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + | 52 |
Adenoma | | 3 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Ovary | + + + + | 53 |
Leukemia Mononuclear | | 7 |
__________________________________________________________________________|____________|
Uterus | + + + + | 53 |
Leukemia Mononuclear | X | 3 |
Polyp Stromal | X | 3 |
__________________________________________________________________________|____________|
Vagina | | 1 |
Fibroma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 53 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Lymph Node | | 11 |
Axillary, Leukemia Mononuclear | | 3 |
Deep Cervical, Leukemia Mononuclear | | 1 |
Iliac, Leukemia Mononuclear | | 5 |
Inguinal, Leukemia Mononuclear | | 4 |
Pancreatic, Leukemia Mononuclear | | 5 |
Renal, Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + | 51 |
Leukemia Mononuclear | X | 19 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 52 |
Leukemia Mononuclear | | 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| | |
DAY ON TEST | 9| 3| 3| 3| | |
| 7| 0| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| | A |
0.25 | 1| 1| 1| 2| | L |
MG/M3 | 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 53 |
Leukemia Mononuclear | X X | 17 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M + + | 44 |
Leukemia Mononuclear | | 15 |
__________________________________________________________________________|____________|
Spleen | + + + + | 53 |
Leukemia Mononuclear | X X X | 33 |
__________________________________________________________________________|____________|
Thymus | + + + + | 51 |
Leukemia Mononuclear | X | 13 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 53 |
Adenocarcinoma | | 1 |
Fibroadenoma | X | 8 |
Fibroadenoma, Multiple | | 2 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + | 52 |
Fibroma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 53 |
Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 53 |
Astrocytoma NOS | | 1 |
Leukemia Mononuclear | | 1 |
Meninges, Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + | 52 |
__________________________________________________________________________|____________|
Lung | + + + + | 53 |
Leukemia Mononuclear | X X X | 26 |
Squamous Cell Carcinoma, Metastatic, | | |
Uncertain Primary Site | | 1 |
Pleura, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + | 53 |
Nasopharyngeal Duct, Leukemia | | |
Mononuclear | | 2 |
__________________________________________________________________________|____________|
Trachea | + + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| | |
DAY ON TEST | 9| 3| 3| 3| | |
| 7| 0| 2| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| | A |
0.25 | 1| 1| 1| 2| | L |
MG/M3 | 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 53 |
Leukemia Mononuclear | | 11 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 53 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + | 53 |
Leukemia Mononuclear | X X X | 33 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 6| 4| 6| 6| 3| 7| 2| 4| 4| 6| 7| 6| 5| 7| 5| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 6| 8| 2| 3| 7| 8| 7| 8| 3| 3| 3| 3| 4| 3| 3| 8| 3| 3| 3| 3| 2| 3| 3|
| 8| 2| 1| 8| 3| 2| 2| 0| 5| 5| 0| 7| 8| 1| 1| 1| 2| 1| 8| 0| 0| 1| 9| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5MG/M3 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 1| 2| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Leukemia Mononuclear| X |
__________________________________________________________________________|
Intestine Large, Rectum | I I + + + + + + I + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Lymphoid Tissue, Leukemia Mononuclear| X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Peyer's Patch, Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Oral Mucosa | + |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Forestomach | + + M + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Lymphoma Malignant, Metastatic, | |
Thymus | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + M + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 6| 4| 6| 6| 3| 7| 2| 4| 4| 6| 7| 6| 5| 7| 5| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 6| 8| 2| 3| 7| 8| 7| 8| 3| 3| 3| 3| 4| 3| 3| 8| 3| 3| 3| 3| 2| 3| 3|
| 8| 2| 1| 8| 3| 2| 2| 0| 5| 5| 0| 7| 8| 1| 1| 1| 2| 1| 8| 0| 0| 1| 9| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5MG/M3 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 1| 2| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X|
C-Cell, Carcinoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + + |
Leukemia Mononuclear | X |
Abdominal, Leukemia Mononuclear | X |
Mediastinum, Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
Bilateral, Adenoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | |
Granulosa-Theca Tumor Benign | X |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Polyp Stromal | X X X X |
Sarcoma Stromal | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node | + |
Axillary, Leukemia Mononuclear | X |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + I M + + + + + + + + + + + + + + M + + + +|
Leukemia Mononuclear | X X X X X |
Lymphoma Malignant, Metastatic, | |
Thymus | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M M + + + + + + + + + + + I + + + + + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 6| 4| 6| 6| 3| 7| 2| 4| 4| 6| 7| 6| 5| 7| 5| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 6| 8| 2| 3| 7| 8| 7| 8| 3| 3| 3| 3| 4| 3| 3| 8| 3| 3| 3| 3| 2| 3| 3|
| 8| 2| 1| 8| 3| 2| 2| 0| 5| 5| 0| 7| 8| 1| 1| 1| 2| 1| 8| 0| 0| 1| 9| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5MG/M3 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 1| 2| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + I + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Fibroadenoma | X X X |
Fibroadenoma, Multiple | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
Pinna, Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Leukemia Mononuclear | X X X X X X X X |
Lymphoma Malignant, Metastatic, | |
Thymus | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 6| 4| 6| 6| 3| 7| 2| 4| 4| 6| 7| 6| 5| 7| 5| 7| 7| 6| 5| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 4| 3| 6| 8| 2| 3| 7| 8| 7| 8| 3| 3| 3| 3| 4| 3| 3| 8| 3| 3| 3| 3| 2| 3| 3|
| 8| 2| 1| 8| 3| 2| 2| 0| 5| 5| 0| 7| 8| 1| 1| 1| 2| 1| 8| 0| 0| 1| 9| 8| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5MG/M3 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2|
| 1| 2| 4| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 3|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 1| 7| 6| 0| 6| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 1| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 9| 9| 2| 6| 2| 5| 3| 9| 2| 2| 3|
| 0| 2| 0| 9| 0| 9| 0| 1| 0| 7| 2| 1| 0| 2| 7| 0| 9| 2| 8| 4| 1| 7| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5MG/M3 | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|
| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Leukemia Mononuclear| |
__________________________________________________________________________|
Intestine Large, Rectum | I + I + + + + I + + + I I + + + + + + + + + + I|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Leukemia Mononuclear| |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Peyer's Patch, Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Oral Mucosa | |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Lymphoma Malignant, Metastatic, | |
Thymus | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pheochromocytoma Benign | X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + M + + + + M + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 1| 7| 6| 0| 6| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 1| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 9| 9| 2| 6| 2| 5| 3| 9| 2| 2| 3|
| 0| 2| 0| 9| 0| 9| 0| 1| 0| 7| 2| 1| 0| 2| 7| 0| 9| 2| 8| 4| 1| 7| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5MG/M3 | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|
| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X |
Pars Distalis, Adenoma | X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + M + + + + + + + + + + + + + M + + + + + +|
Leukemia Mononuclear | X |
C-Cell, Adenoma | |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Leukemia Mononuclear | |
Abdominal, Leukemia Mononuclear | |
Mediastinum, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X |
Bilateral, Adenoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Malignant | X |
Granulosa-Theca Tumor Benign | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Polyp Stromal | X X|
Sarcoma Stromal | X |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node | + |
Axillary, Leukemia Mononuclear | X |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + I + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Lymphoma Malignant, Metastatic, | |
Thymus | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + I + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 1| 7| 6| 0| 6| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 1| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 9| 9| 2| 6| 2| 5| 3| 9| 2| 2| 3|
| 0| 2| 0| 9| 0| 9| 0| 1| 0| 7| 2| 1| 0| 2| 7| 0| 9| 2| 8| 4| 1| 7| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5MG/M3 | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|
| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Fibroadenoma | X X X |
Fibroadenoma, Multiple | X X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Skin | + + + + + + + M + + + + + + + + + + + + + + + +|
Fibroma | |
Pinna, Fibroma | X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Leukemia Mononuclear | X X X X X X |
Lymphoma Malignant, Metastatic, | |
Thymus | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 1| 7| 6| 0| 6| 7| 4| 7| 7| 7|
DAY ON TEST | 3| 0| 3| 1| 3| 2| 3| 3| 3| 2| 3| 3| 3| 3| 9| 9| 2| 6| 2| 5| 3| 9| 2| 2| 3|
| 0| 2| 0| 9| 0| 9| 0| 1| 0| 7| 2| 1| 0| 2| 7| 0| 9| 2| 8| 4| 1| 7| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5MG/M3 | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5|
| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| | |
DAY ON TEST | 7| 6| 2| 2| 3| | |
| 0| 8| 9| 9| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| | A |
0.5MG/M3 | 5| 5| 5| 5| 5| | L |
| 3| 4| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 54 |
Lymphoid Tissue, Leukemia Mononuclear| | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 53 |
Lymphoid Tissue, Leukemia Mononuclear| | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 53 |
Leukemia Mononuclear | | 3 |
Peyer's Patch, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + | 54 |
Leukemia Mononuclear | X X | 22 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 54 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 54 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 53 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 54 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 54 |
Leukemia Mononuclear | X | 6 |
Lymphoma Malignant, Metastatic, | | |
Thymus | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 54 |
Leukemia Mononuclear | X | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 54 |
Leukemia Mononuclear | X | 5 |
Pheochromocytoma Benign | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| | |
DAY ON TEST | 7| 6| 2| 2| 3| | |
| 0| 8| 9| 9| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| | A |
0.5MG/M3 | 5| 5| 5| 5| 5| | L |
| 3| 4| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 54 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 49 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 54 |
Leukemia Mononuclear | X | 9 |
Pars Distalis, Adenoma | X X | 22 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 52 |
Leukemia Mononuclear | | 1 |
C-Cell, Adenoma | X | 2 |
C-Cell, Carcinoma | | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 5 |
Leukemia Mononuclear | | 1 |
Abdominal, Leukemia Mononuclear | | 1 |
Mediastinum, Leukemia Mononuclear | | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 54 |
Adenoma | X | 2 |
Carcinoma | | 1 |
Bilateral, Adenoma | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + | 54 |
Granulosa Cell Tumor Malignant | | 1 |
Granulosa-Theca Tumor Benign | | 1 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + | 54 |
Leukemia Mononuclear | | 3 |
Polyp Stromal | X | 7 |
Sarcoma Stromal | | 1 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 54 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
Axillary, Leukemia Mononuclear | | 2 |
Deep Cervical, Leukemia Mononuclear | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| | |
DAY ON TEST | 7| 6| 2| 2| 3| | |
| 0| 8| 9| 9| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| | A |
0.5MG/M3 | 5| 5| 5| 5| 5| | L |
| 3| 4| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Iliac, Leukemia Mononuclear | X | 3 |
Inguinal, Leukemia Mononuclear | X | 2 |
Pancreatic, Leukemia Mononuclear | | 1 |
Renal, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + | 49 |
Leukemia Mononuclear | X X | 10 |
Lymphoma Malignant, Metastatic, | | |
Thymus | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 50 |
Leukemia Mononuclear | X | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 54 |
Leukemia Mononuclear | X | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + M | 50 |
Leukemia Mononuclear | X | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 54 |
Leukemia Mononuclear | X X | 22 |
__________________________________________________________________________|____________|
Thymus | I + + + + | 52 |
Leukemia Mononuclear | | 6 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 54 |
Adenocarcinoma | | 1 |
Fibroadenoma | X | 7 |
Fibroadenoma, Multiple | | 2 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + | 53 |
Fibroma | | 1 |
Pinna, Fibroma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 54 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 54 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 3| 5| 7| 7| 7| | |
DAY ON TEST | 7| 6| 2| 2| 3| | |
| 0| 8| 9| 9| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| | A |
0.5MG/M3 | 5| 5| 5| 5| 5| | L |
| 3| 4| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + | 53 |
__________________________________________________________________________|____________|
Lung | + + + + + | 54 |
Alveolar/Bronchiolar Adenoma | | 1 |
Leukemia Mononuclear | X X | 16 |
Lymphoma Malignant, Metastatic, | | |
Thymus | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + | 54 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 54 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 6 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 54 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 54 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + | 54 |
Leukemia Mononuclear | X X | 23 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 6| 5| 7| 5| 6| 7| 7| 6| 4| 7| 7| 5| 6| 6| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 3| 6| 6| 2| 3| 1| 3| 3| 1| 7| 2| 3| 1| 8| 3| 3| 7| 2| 5| 3| 3| 6| 2| 5| 3|
| 6| 2| 5| 6| 7| 4| 6| 6| 8| 9| 0| 6| 8| 2| 7| 1| 7| 2| 7| 6| 3| 9| 1| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3|
| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 3| 4| 5| 7| 8| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | |
Schwannoma Benign | |
__________________________________________________________________________|
Oral Mucosa | + + + |
Squamous Cell Papilloma | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Osteosarcoma, Metastatic, Bone | |
Pheochromocytoma Benign | X X X X X X |
Bilateral, Pheochromocytoma Benign | X X X X|
__________________________________________________________________________|
Islets, Pancreatic | + + + I + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + I + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pars Distalis, Adenoma | X X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 6| 5| 7| 5| 6| 7| 7| 6| 4| 7| 7| 5| 6| 6| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 3| 6| 6| 2| 3| 1| 3| 3| 1| 7| 2| 3| 1| 8| 3| 3| 7| 2| 5| 3| 3| 6| 2| 5| 3|
| 6| 2| 5| 6| 7| 4| 6| 6| 8| 9| 0| 6| 8| 2| 7| 1| 7| 2| 7| 6| 3| 9| 1| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3|
| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 3| 4| 5| 7| 8| 2| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Cholangiocarcinoma, Metastatic, Liver| |
Paraganglioma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Iliac, Leukemia Mononuclear | X X X X X |
Inguinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X |
Renal, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M + + + + + M + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + I + + I +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + M + + + + + + + + + + + + + M + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + I + + + + + + + + + I + M +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 6| 5| 7| 5| 6| 7| 7| 6| 4| 7| 7| 5| 6| 6| 7| 7| 5| 7| 6| 7|
DAY ON TEST | 3| 6| 6| 2| 3| 1| 3| 3| 1| 7| 2| 3| 1| 8| 3| 3| 7| 2| 5| 3| 3| 6| 2| 5| 3|
| 6| 2| 5| 6| 7| 4| 6| 6| 8| 9| 0| 6| 8| 2| 7| 1| 7| 2| 7| 6| 3| 9| 1| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3|
| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 3| 4| 5| 7| 8| 2| 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + M + + + + + M + + + M + + M M +|
Adenocarcinoma | X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Humerus, Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glioma NOS | X |
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X |
Osteosarcoma, Metastatic, Bone | |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Osteosarcoma, Metastatic, Bone | |
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 5| 7| 1| 4| 7| 7| 2| 7| 6| 6| 6| 5| 6| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7| 5|
DAY ON TEST | 2| 3| 3| 1| 9| 3| 0| 6| 3| 5| 5| 3| 9| 8| 5| 3| 3| 3| 0| 3| 3| 2| 9| 0| 0|
| 6| 9| 7| 7| 6| 3| 8| 2| 7| 7| 8| 7| 7| 6| 0| 7| 3| 3| 3| 3| 4| 2| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | X |
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
Schwannoma Benign | X |
__________________________________________________________________________|
Oral Mucosa | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Pancreas | + + + M + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Osteosarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Osteosarcoma, Metastatic, Bone | X |
Pheochromocytoma Benign | X X X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + M + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + M + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 5| 7| 1| 4| 7| 7| 2| 7| 6| 6| 6| 5| 6| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7| 5|
DAY ON TEST | 2| 3| 3| 1| 9| 3| 0| 6| 3| 5| 5| 3| 9| 8| 5| 3| 3| 3| 0| 3| 3| 2| 9| 0| 0|
| 6| 9| 7| 7| 6| 3| 8| 2| 7| 7| 8| 7| 7| 6| 0| 7| 3| 3| 3| 3| 4| 2| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
Cholangiocarcinoma, Metastatic, Liver| X |
Paraganglioma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X |
Interstitial Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Osteosarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Leukemia Mononuclear | X |
Inguinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X |
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + I + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 5| 7| 1| 4| 7| 7| 2| 7| 6| 6| 6| 5| 6| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7| 5|
DAY ON TEST | 2| 3| 3| 1| 9| 3| 0| 6| 3| 5| 5| 3| 9| 8| 5| 3| 3| 3| 0| 3| 3| 2| 9| 0| 0|
| 6| 9| 7| 7| 6| 3| 8| 2| 7| 7| 8| 7| 7| 6| 0| 7| 3| 3| 3| 3| 4| 2| 3| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + M M + + + + + + + + M + M M + + + + + + + + + +|
Adenocarcinoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + I|
Keratoacanthoma | X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Humerus, Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glioma NOS | |
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X X X |
Osteosarcoma, Metastatic, Bone | X |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Osteosarcoma, Metastatic, Bone | X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 5| | |
DAY ON TEST | 7| 3| 1| 3| | |
| 9| 6| 0| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
0.0MG/M3 | 6| 6| 6| 6| | L |
| 5| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + | 54 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Liver | + + + + | 54 |
Cholangiocarcinoma | | 1 |
Hepatocellular Carcinoma | X | 1 |
Hepatocellular Adenoma | | 1 |
Leukemia Mononuclear | X | 27 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
Schwannoma Benign | | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | | 3 |
Squamous Cell Papilloma | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 53 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 54 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 54 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 54 |
__________________________________________________________________________|____________|
Tooth | | 9 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 54 |
Leukemia Mononuclear | X | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 54 |
Leukemia Mononuclear | | 5 |
Osteosarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 54 |
Leukemia Mononuclear | X | 5 |
Osteosarcoma, Metastatic, Bone | | 1 |
Pheochromocytoma Benign | | 11 |
Bilateral, Pheochromocytoma Benign | | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 52 |
Adenoma | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 52
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 5| | |
DAY ON TEST | 7| 3| 1| 3| | |
| 9| 6| 0| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
0.0MG/M3 | 6| 6| 6| 6| | L |
| 5| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 54 |
Leukemia Mononuclear | X | 6 |
Pars Distalis, Adenoma | X X | 13 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 53 |
Bilateral, C-Cell, Adenoma | | 1 |
C-Cell, Adenoma | | 7 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 4 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
Paraganglioma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + | 54 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + | 54 |
Adenoma | | 2 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + | 54 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + | 54 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Testes | + + + + | 54 |
Bilateral, Interstitial Cell, Adenoma| X X X | 32 |
Interstitial Cell, Adenoma | X | 13 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 54 |
Leukemia Mononuclear | | 5 |
Osteosarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + | 11 |
Iliac, Leukemia Mononuclear | | 6 |
Inguinal, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | | 3 |
Renal, Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + | 51 |
Leukemia Mononuclear | X | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 52 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 53
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 5| | |
DAY ON TEST | 7| 3| 1| 3| | |
| 9| 6| 0| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
0.0MG/M3 | 6| 6| 6| 6| | L |
| 5| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X | 15 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + | 54 |
Leukemia Mononuclear | X | 14 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + | 51 |
Leukemia Mononuclear | X | 19 |
__________________________________________________________________________|____________|
Spleen | + + + + | 54 |
Leukemia Mononuclear | X | 31 |
__________________________________________________________________________|____________|
Thymus | + + + + | 49 |
Leukemia Mononuclear | X | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 43 |
Adenocarcinoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + | 53 |
Keratoacanthoma | | 4 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 54 |
Humerus, Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 54 |
Glioma NOS | | 1 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + | 54 |
__________________________________________________________________________|____________|
Lung | + + + + | 54 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | X | 26 |
Osteosarcoma, Metastatic, Bone | | 1 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + | 54 |
__________________________________________________________________________|____________|
Trachea | + + + + | 54 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
Carcinoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 5| | |
DAY ON TEST | 7| 3| 1| 3| | |
| 9| 6| 0| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| | A |
0.0MG/M3 | 6| 6| 6| 6| | L |
| 5| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 54 |
Leukemia Mononuclear | | 2 |
Osteosarcoma, Metastatic, Bone | | 1 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 54 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + | 54 |
Leukemia Mononuclear | X | 31 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 5| 3| 5| 7| 6| 7| 6| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 8| 6| 5| 3| 4| 3| 4| 0| 7| 7| 8| 0| 4| 3| 3| 3| 1| 4| 0| 3| 0| 3| 7| 4|
| 7| 0| 3| 1| 3| 6| 7| 0| 0| 9| 0| 5| 7| 7| 7| 7| 2| 5| 4| 3| 7| 2| 3| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.12 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7|
MG/M3 | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 4| 5| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Sarcoma | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Peyer's Patch, Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Leukemia Mononuclear | X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | |
Lipoma | X |
__________________________________________________________________________|
Oral Mucosa | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tongue | + |
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | X X |
Pheochromocytoma Benign | X X X X X|
Bilateral, Pheochromocytoma Benign | X X |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 5| 3| 5| 7| 6| 7| 6| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 8| 6| 5| 3| 4| 3| 4| 0| 7| 7| 8| 0| 4| 3| 3| 3| 1| 4| 0| 3| 0| 3| 7| 4|
| 7| 0| 3| 1| 3| 6| 7| 0| 0| 9| 0| 5| 7| 7| 7| 7| 2| 5| 4| 3| 7| 2| 3| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.12 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7|
MG/M3 | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 4| 5| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
Leukemia Mononuclear | X X X X|
Pars Distalis, Adenoma | X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
C-Cell, Adenoma | |
C-Cell, Carcinoma | X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Thoracic, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Testes | X |
Mesothelioma NOS | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X |
Tunic, Mesothelioma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + +|
Leukemia Mononuclear | X X X X|
__________________________________________________________________________|
Lymph Node | + + +|
Iliac, Leukemia Mononuclear | |
Inguinal, Leukemia Mononuclear | X|
Pancreatic, Leukemia Mononuclear | X X|
Renal, Leukemia Mononuclear | X|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + I + + + + + + + + + + + + + M + + + + +|
Carcinoma, Metastatic, Preputial | |
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 5| 3| 5| 7| 6| 7| 6| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 8| 6| 5| 3| 4| 3| 4| 0| 7| 7| 8| 0| 4| 3| 3| 3| 1| 4| 0| 3| 0| 3| 7| 4|
| 7| 0| 3| 1| 3| 6| 7| 0| 0| 9| 0| 5| 7| 7| 7| 7| 2| 5| 4| 3| 7| 2| 3| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.12 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7|
MG/M3 | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 4| 5| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Gland | X |
Leukemia Mononuclear | X X X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + A + + + + + + +|
Leukemia Mononuclear | X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | X |
Fibroadenoma, Multiple | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Keratoacanthoma | |
Lipoma | |
Squamous Cell Carcinoma | X |
Lip, Trichoepithelioma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasopharyngeal Duct, Leukemia | |
Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 5| 3| 5| 7| 6| 7| 6| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 8| 6| 5| 3| 4| 3| 4| 0| 7| 7| 8| 0| 4| 3| 3| 3| 1| 4| 0| 3| 0| 3| 7| 4|
| 7| 0| 3| 1| 3| 6| 7| 0| 0| 9| 0| 5| 7| 7| 7| 7| 2| 5| 4| 3| 7| 2| 3| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.12 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7|
MG/M3 | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 4| 5| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +|
Leukemia Mononuclear | X X|
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Medulla | X |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X|
Mesothelioma Malignant | X |
Mesothelioma NOS | X |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 0| 9| 9| 3| 2| 2| 3| 0| 4| 5| 8| 3| 5| 3| 3| 3| 5| 3| 2| 2| 8| 3| 3| 3|
| 9| 4| 2| 8| 6| 6| 0| 6| 8| 0| 0| 3| 6| 8| 7| 3| 2| 2| 6| 0| 6| 2| 3| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0.12 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/M3 | 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Sarcoma | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + M + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Peyer's Patch, Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Mesentery | + + |
Leukemia Mononuclear | X |
Lipoma | |
__________________________________________________________________________|
Oral Mucosa | + + |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + M + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Tongue | |
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X |
Bilateral, Pheochromocytoma Benign | X X X X|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 0| 9| 9| 3| 2| 2| 3| 0| 4| 5| 8| 3| 5| 3| 3| 3| 5| 3| 2| 2| 8| 3| 3| 3|
| 9| 4| 2| 8| 6| 6| 0| 6| 8| 0| 0| 3| 6| 8| 7| 3| 2| 2| 6| 0| 6| 2| 3| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0.12 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/M3 | 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Islets, Pancreatic | + + M + + + + + + + + + + + + + + M + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Pars Distalis, Adenoma | X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X |
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Thoracic, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mesothelioma Malignant, Metastatic, | |
Testes | |
Mesothelioma NOS | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X |
Tunic, Mesothelioma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Iliac, Leukemia Mononuclear | X X X X |
Inguinal, Leukemia Mononuclear | |
Pancreatic, Leukemia Mononuclear | X X X X X X X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + I + + + + + + + + + + I|
Carcinoma, Metastatic, Preputial | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 0| 9| 9| 3| 2| 2| 3| 0| 4| 5| 8| 3| 5| 3| 3| 3| 5| 3| 2| 2| 8| 3| 3| 3|
| 9| 4| 2| 8| 6| 6| 0| 6| 8| 0| 0| 3| 6| 8| 7| 3| 2| 2| 6| 0| 6| 2| 3| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0.12 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/M3 | 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Gland | |
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + M + + + + + + + + + I + + + M + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + M + + + + + + + M + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M + + + M + M + + + +|
Adenocarcinoma | |
Fibroadenoma, Multiple | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
Keratoacanthoma | X |
Lipoma | X|
Squamous Cell Carcinoma | |
Lip, Trichoepithelioma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + A + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + A + + + + + + +|
Nasopharyngeal Duct, Leukemia | |
Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 5| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7| 6| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 0| 9| 9| 3| 2| 2| 3| 0| 4| 5| 8| 3| 5| 3| 3| 3| 5| 3| 2| 2| 8| 3| 3| 3|
| 9| 4| 2| 8| 6| 6| 0| 6| 8| 0| 0| 3| 6| 8| 7| 3| 2| 2| 6| 0| 6| 2| 3| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
0.12 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/M3 | 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 4| 5| 6|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Medulla | |
__________________________________________________________________________|
Urethra | + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X |
Mesothelioma Malignant | |
Mesothelioma NOS | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 5| 6| 5| | |
DAY ON TEST | 6| 8| 6| | |
| 6| 3| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.12 | 0| 0| 1| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
Leukemia Mononuclear | X | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 52 |
Leukemia Mononuclear | X | 1 |
Peyer's Patch, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + I | 51 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Hepatocellular Carcinoma | | 1 |
Leukemia Mononuclear | X X X | 31 |
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Leukemia Mononuclear | | 1 |
Lipoma | X | 2 |
__________________________________________________________________________|____________|
Oral Mucosa | | 2 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 52 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Tongue | | 1 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Tooth | | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Leukemia Mononuclear | X X X | 14 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Adenoma | | 1 |
Leukemia Mononuclear | X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 64
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 5| 6| 5| | |
DAY ON TEST | 6| 8| 6| | |
| 6| 3| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.12 | 0| 0| 1| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Leukemia Mononuclear | X X | 9 |
Pheochromocytoma Malignant | | 3 |
Pheochromocytoma Benign | X | 10 |
Bilateral, Pheochromocytoma Benign | | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 51 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 51 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 51 |
Leukemia Mononuclear | | 9 |
Pars Distalis, Adenoma | | 12 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 53 |
Leukemia Mononuclear | X | 2 |
C-Cell, Adenoma | | 1 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Thoracic, Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 3 |
__________________________________________________________________________|____________|
Epididymis | + + + | 53 |
Mesothelioma Malignant, Metastatic, | | |
Testes | | 1 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 53 |
Carcinoma | | 3 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Prostate | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Testes | + + + | 53 |
Leukemia Mononuclear | | 2 |
Bilateral, Interstitial Cell, Adenoma| X | 38 |
Interstitial Cell, Adenoma | X | 8 |
Tunic, Mesothelioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 65
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 5| 6| 5| | |
DAY ON TEST | 6| 8| 6| | |
| 6| 3| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.12 | 0| 0| 1| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 52 |
Leukemia Mononuclear | X X X | 12 |
__________________________________________________________________________|____________|
Lymph Node | + + | 14 |
Iliac, Leukemia Mononuclear | X | 5 |
Inguinal, Leukemia Mononuclear | | 1 |
Pancreatic, Leukemia Mononuclear | X X | 11 |
Renal, Leukemia Mononuclear | X X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 49 |
Carcinoma, Metastatic, Preputial | | |
Gland | | 1 |
Leukemia Mononuclear | X X X | 21 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 53 |
Leukemia Mononuclear | X X X | 22 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Leukemia Mononuclear | X X X | 20 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 49 |
Leukemia Mononuclear | X X X | 25 |
__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Hemangiosarcoma | | 1 |
Leukemia Mononuclear | X X X | 36 |
__________________________________________________________________________|____________|
Thymus | M + + | 48 |
Leukemia Mononuclear | X X | 13 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M M | 48 |
Adenocarcinoma | | 1 |
Fibroadenoma, Multiple | | 1 |
__________________________________________________________________________|____________|
Skin | + + + | 53 |
Fibroma | | 1 |
Keratoacanthoma | | 1 |
Lipoma | | 1 |
Squamous Cell Carcinoma | | 1 |
Lip, Trichoepithelioma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 66
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 5| 6| 5| | |
DAY ON TEST | 6| 8| 6| | |
| 6| 3| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| | A |
0.12 | 0| 0| 1| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 52 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Leukemia Mononuclear | X X X | 29 |
__________________________________________________________________________|____________|
Nose | + + + | 52 |
Nasopharyngeal Duct, Leukemia | | |
Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 52 |
Leukemia Mononuclear | X X | 9 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Medulla | | 1 |
__________________________________________________________________________|____________|
Urethra | | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Leukemia Mononuclear | X | 4 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Leukemia Mononuclear | X X X | 36 |
Mesothelioma Malignant | | 1 |
Mesothelioma NOS | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 67
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 6| 4| 5| 5| 6| 5| 6| 7| 7| 2| 7| 7| 7| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 9| 0| 0| 3| 9| 5| 2| 3| 4| 3| 3| 7| 2| 3| 3| 3| 0| 1| 3| 3| 3|
| 3| 3| 4| 1| 7| 6| 7| 2| 7| 1| 1| 5| 3| 3| 7| 9| 7| 3| 7| 5| 6| 1| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
MG/M3 | 1| 2| 3| 4| 6| 7| 9| 0| 1| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X|
Lymphoma Malignant | |
__________________________________________________________________________|
Oral Mucosa | + |
Squamous Cell Carcinoma | X |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Lymphoma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Capsule, Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + M + + + + + + +|
Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 6| 4| 5| 5| 6| 5| 6| 7| 7| 2| 7| 7| 7| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 9| 0| 0| 3| 9| 5| 2| 3| 4| 3| 3| 7| 2| 3| 3| 3| 0| 1| 3| 3| 3|
| 3| 3| 4| 1| 7| 6| 7| 2| 7| 1| 1| 5| 3| 3| 7| 9| 7| 3| 7| 5| 6| 1| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
MG/M3 | 1| 2| 3| 4| 6| 7| 9| 0| 1| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Carcinoma | X |
Leukemia Mononuclear | X X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Pars Distalis, Adenoma | X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + + |
Fibroma | X |
Mediastinum, Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node | + + + + |
Axillary, Leukemia Mononuclear | |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X X X |
Pancreatic, Lymphoma Malignant | |
Renal, Leukemia Mononuclear | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M + + + + + M + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 6| 4| 5| 5| 6| 5| 6| 7| 7| 2| 7| 7| 7| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 9| 0| 0| 3| 9| 5| 2| 3| 4| 3| 3| 7| 2| 3| 3| 3| 0| 1| 3| 3| 3|
| 3| 3| 4| 1| 7| 6| 7| 2| 7| 1| 1| 5| 3| 3| 7| 9| 7| 3| 7| 5| 6| 1| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
MG/M3 | 1| 2| 3| 4| 6| 7| 9| 0| 1| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + + + + + + + + + M + M + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X|
Lymphoma Malignant | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + M + + + + + + + + + + + + + + + + +|
Fibroadenoma | X|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Lipoma | X |
Squamous Cell Papilloma | |
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Medulla | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 6| 4| 5| 5| 6| 5| 6| 7| 7| 2| 7| 7| 7| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 9| 0| 0| 3| 9| 5| 2| 3| 4| 3| 3| 7| 2| 3| 3| 3| 0| 1| 3| 3| 3|
| 3| 3| 4| 1| 7| 6| 7| 2| 7| 1| 1| 5| 3| 3| 7| 9| 7| 3| 7| 5| 6| 1| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
MG/M3 | 1| 2| 3| 4| 6| 7| 9| 0| 1| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
Lymphoma Malignant | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X X|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 6| 6| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 1| 7| 3| 3| 9| 3| 7| 1| 7| 3| 8| 3| 2| 3| 3| 0| 5| 2| 1| 9| 3| 5| 3| 3| 3|
| 7| 6| 3| 8| 7| 6| 1| 3| 9| 7| 3| 7| 5| 6| 6| 1| 0| 8| 7| 2| 7| 1| 6| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
MG/M3 | 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 8| 1| 3| 4| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + I + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A + + + + + A + + + + + + A + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + A + + + + + A + + + M + + A + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
Lymphoma Malignant | X |
__________________________________________________________________________|
Oral Mucosa | + + |
Squamous Cell Carcinoma | X |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + M + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Capsule, Leukemia Mononuclear | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
Pheochromocytoma Malignant | X X |
Pheochromocytoma Benign | X X X X X X X X X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 6| 6| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 1| 7| 3| 3| 9| 3| 7| 1| 7| 3| 8| 3| 2| 3| 3| 0| 5| 2| 1| 9| 3| 5| 3| 3| 3|
| 7| 6| 3| 8| 7| 6| 1| 3| 9| 7| 3| 7| 5| 6| 6| 1| 0| 8| 7| 2| 7| 1| 6| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
MG/M3 | 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 8| 1| 3| 4| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Carcinoma | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Pars Distalis, Adenoma | X X X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | A + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | |
C-Cell, Adenoma | X |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Fibroma | |
Mediastinum, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + I + + + + + + + + + + + + +|
Adenoma | X X|
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + A + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Axillary, Leukemia Mononuclear | |
Deep Cervical, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | X X |
Pancreatic, Leukemia Mononuclear | X X |
Pancreatic, Lymphoma Malignant | X |
Renal, Leukemia Mononuclear | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + I + + M + + + + A + + + + +|
Leukemia Mononuclear | X X X X X X|
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 6| 6| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 1| 7| 3| 3| 9| 3| 7| 1| 7| 3| 8| 3| 2| 3| 3| 0| 5| 2| 1| 9| 3| 5| 3| 3| 3|
| 7| 6| 3| 8| 7| 6| 1| 3| 9| 7| 3| 7| 5| 6| 6| 1| 0| 8| 7| 2| 7| 1| 6| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
MG/M3 | 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 8| 1| 3| 4| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + I +|
Leukemia Mononuclear | X X X X|
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + A + + M + + + + + + M + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Spleen | + + + + + + A + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
Lymphoma Malignant | X |
__________________________________________________________________________|
Thymus | + + M + + + A + + + + + + M + + + + + A + + + + +|
Leukemia Mononuclear | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Fibroadenoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Lipoma | |
Squamous Cell Papilloma | X X |
Subcutaneous Tissue, Sarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | |
Leukemia Mononuclear | X X X X X X X X X X X|
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Medulla | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 6| 6| 4| 7| 6| 7| 7| 7|
DAY ON TEST | 1| 7| 3| 3| 9| 3| 7| 1| 7| 3| 8| 3| 2| 3| 3| 0| 5| 2| 1| 9| 3| 5| 3| 3| 3|
| 7| 6| 3| 8| 7| 6| 1| 3| 9| 7| 3| 7| 5| 6| 6| 1| 0| 8| 7| 2| 7| 1| 6| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
MG/M3 | 3| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 8| 1| 3| 4| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + A + + + + +|
Leukemia Mononuclear | X X X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 6| 7| 6| | |
DAY ON TEST | 8| 2| 8| | |
| 4| 6| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
0.25 | 4| 4| 5| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 51 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 50 |
Leukemia Mononuclear | X | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 48 |
Leukemia Mononuclear | X X | 6 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Hepatocellular Adenoma | | 2 |
Leukemia Mononuclear | X X X | 37 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | + | 4 |
Squamous Cell Carcinoma | X | 3 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Leukemia Mononuclear | X | 5 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
Leukemia Mononuclear | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 52 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Tooth | | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Leukemia Mononuclear | | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Leukemia Mononuclear | | 5 |
Capsule, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 76
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 6| 7| 6| | |
DAY ON TEST | 8| 2| 8| | |
| 4| 6| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
0.25 | 4| 4| 5| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 7 |
Pheochromocytoma Malignant | | 2 |
Pheochromocytoma Benign | | 12 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 52 |
Adenoma | | 1 |
Carcinoma | | 1 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 51 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Leukemia Mononuclear | | 8 |
Pars Distalis, Adenoma | X X | 18 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 51 |
Leukemia Mononuclear | X | 1 |
C-Cell, Adenoma | X | 2 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 5 |
Fibroma | | 1 |
Mediastinum, Leukemia Mononuclear | | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 52 |
Adenoma | | 3 |
Carcinoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 53 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________|____________|
Testes | + + + | 53 |
Bilateral, Interstitial Cell, Adenoma| X X X | 38 |
Interstitial Cell, Adenoma | | 7 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 52 |
Leukemia Mononuclear | X | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 77
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 6| 7| 6| | |
DAY ON TEST | 8| 2| 8| | |
| 4| 6| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
0.25 | 4| 4| 5| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + | 11 |
Axillary, Leukemia Mononuclear | X | 1 |
Deep Cervical, Leukemia Mononuclear | X | 1 |
Iliac, Leukemia Mononuclear | X | 5 |
Pancreatic, Leukemia Mononuclear | X | 6 |
Pancreatic, Lymphoma Malignant | | 1 |
Renal, Leukemia Mononuclear | X | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + I | 47 |
Leukemia Mononuclear | X | 16 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 52 |
Leukemia Mononuclear | X | 18 |
Squamous Cell Carcinoma, Metastatic, | | |
Oral Mucosa | X | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Hemangioma | | 1 |
Leukemia Mononuclear | X | 15 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 46 |
Leukemia Mononuclear | X | 19 |
__________________________________________________________________________|____________|
Spleen | + + + | 51 |
Leukemia Mononuclear | X X X | 38 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + | 48 |
Leukemia Mononuclear | X | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 49 |
Fibroadenoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + | 53 |
Keratoacanthoma | X | 1 |
Lipoma | | 1 |
Squamous Cell Papilloma | | 2 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 78
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 6| 7| 6| | |
DAY ON TEST | 8| 2| 8| | |
| 4| 6| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
0.25 | 4| 4| 5| | L |
MG/M3 | 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Leukemia Mononuclear | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 53 |
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Mononuclear | X | 28 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Medulla | | 1 |
__________________________________________________________________________|____________|
Nose | + + + | 53 |
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 2 |
Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 52 |
Leukemia Mononuclear | X | 12 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Leukemia Mononuclear | X X X | 38 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 79
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 6| 6| 4| 4| 7| 7| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 3| 4| 9| 7| 0| 5| 3| 3| 9| 3| 2| 8| 6| 3| 3| 3| 2| 3| 3| 3| 8| 1| 3| 3| 5|
| 6| 0| 7| 1| 2| 4| 3| 3| 9| 6| 8| 8| 3| 8| 4| 3| 0| 6| 7| 6| 4| 3| 3| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 4| 5| 7| 8| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
Peyer's Patch, Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | |
Leukemia Mononuclear | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X X X |
Bilateral, Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + M I + A + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 6| 6| 4| 4| 7| 7| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 3| 4| 9| 7| 0| 5| 3| 3| 9| 3| 2| 8| 6| 3| 3| 3| 2| 3| 3| 3| 8| 1| 3| 3| 5|
| 6| 0| 7| 1| 2| 4| 3| 3| 9| 6| 8| 8| 3| 8| 4| 3| 0| 6| 7| 6| 4| 3| 3| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 4| 5| 7| 8| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X |
Pars Distalis, Adenoma | X X X X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + A + + + + + + + +|
C-Cell, Adenoma | X |
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Paraganglioma | X |
Abdominal, Chondrosarcoma | |
Mediastinum, Leukemia Mononuclear | |
Thoracic, Chordoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X|
__________________________________________________________________________|
Lymph Node | + + + +|
Axillary, Leukemia Mononuclear | |
Iliac, Leukemia Mononuclear | |
Inguinal, Leukemia Mononuclear | X|
Pancreatic, Leukemia Mononuclear | X X|
Renal, Leukemia Mononuclear | X X|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X|
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 6| 6| 4| 4| 7| 7| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 3| 4| 9| 7| 0| 5| 3| 3| 9| 3| 2| 8| 6| 3| 3| 3| 2| 3| 3| 3| 8| 1| 3| 3| 5|
| 6| 0| 7| 1| 2| 4| 3| 3| 9| 6| 8| 8| 3| 8| 4| 3| 0| 6| 7| 6| 4| 3| 3| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 4| 5| 7| 8| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + M + + + + + + + + M + I + + + + + + + + + + + +|
Leukemia Mononuclear | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + M M M + + + + + + + + + +|
Fibroadenoma | X |
Leukemia Mononuclear | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | |
Basal Cell Carcinoma | X |
Fibroma | X X |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Osteosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Chordoma, Metastatic, Tissue NOS | |
Leukemia Mononuclear | X X X X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasopharyngeal Duct, Leukemia | |
Mononuclear | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X|
Renal Tubule, Adenoma | X |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 6| 6| 7| 7| 6| 7| 6| 6| 5| 6| 6| 4| 4| 7| 7| 7| 5| 7| 7| 7| 6|
DAY ON TEST | 3| 4| 9| 7| 0| 5| 3| 3| 9| 3| 2| 8| 6| 3| 3| 3| 2| 3| 3| 3| 8| 1| 3| 3| 5|
| 6| 0| 7| 1| 2| 4| 3| 3| 9| 6| 8| 8| 3| 8| 4| 3| 0| 6| 7| 6| 4| 3| 3| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 4| 5| 7| 8| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 7| 4| 7| 3| 6| 7| 4| 5| 6| 7| 6| 6| 6| 5| 7| 5| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 1| 3| 2| 7| 3| 6| 5| 2| 3| 2| 2| 8| 8| 3| 7| 2| 9|
| 7| 0| 7| 6| 3| 7| 3| 3| 9| 7| 0| 6| 3| 0| 2| 8| 3| 8| 9| 8| 4| 7| 6| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5MG/M3 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|
| 5| 6| 7| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Large, Rectum | + I + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
Peyer's Patch, Leukemia Mononuclear | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Mesentery | + |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X |
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X X X X |
Bilateral, Pheochromocytoma Benign | X|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 7| 4| 7| 3| 6| 7| 4| 5| 6| 7| 6| 6| 6| 5| 7| 5| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 1| 3| 2| 7| 3| 6| 5| 2| 3| 2| 2| 8| 8| 3| 7| 2| 9|
| 7| 0| 7| 6| 3| 7| 3| 3| 9| 7| 0| 6| 3| 0| 2| 8| 3| 8| 9| 8| 4| 7| 6| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5MG/M3 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|
| 5| 6| 7| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Leukemia Mononuclear | X X X X X X X |
Pars Distalis, Adenoma | X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Adenoma | |
C-Cell, Carcinoma | X |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Paraganglioma | |
Abdominal, Chondrosarcoma | X |
Mediastinum, Leukemia Mononuclear | X |
Thoracic, Chordoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X|
Interstitial Cell, Adenoma | X X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Axillary, Leukemia Mononuclear | X |
Iliac, Leukemia Mononuclear | X X |
Inguinal, Leukemia Mononuclear | X |
Pancreatic, Leukemia Mononuclear | X X X X |
Renal, Leukemia Mononuclear | X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | I + + + + + + + M + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 7| 4| 7| 3| 6| 7| 4| 5| 6| 7| 6| 6| 6| 5| 7| 5| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 1| 3| 2| 7| 3| 6| 5| 2| 3| 2| 2| 8| 8| 3| 7| 2| 9|
| 7| 0| 7| 6| 3| 7| 3| 3| 9| 7| 0| 6| 3| 0| 2| 8| 3| 8| 9| 8| 4| 7| 6| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5MG/M3 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|
| 5| 6| 7| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + M M + + + + M + +|
Leukemia Mononuclear | X X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + M + + + + + + + + + M + + + + + + + M M +|
Fibroadenoma | |
Leukemia Mononuclear | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basal Cell Adenoma | X |
Basal Cell Carcinoma | |
Fibroma | X |
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Leukemia Mononuclear | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Chordoma, Metastatic, Tissue NOS | X |
Leukemia Mononuclear | X X X X X X X X X X X X X X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasopharyngeal Duct, Leukemia | |
Mononuclear | X |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X |
Renal Tubule, Adenoma | |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 7| 4| 7| 3| 6| 7| 4| 5| 6| 7| 6| 6| 6| 5| 7| 5| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 8| 3| 1| 3| 2| 7| 3| 6| 5| 2| 3| 2| 2| 8| 8| 3| 7| 2| 9|
| 7| 0| 7| 6| 3| 7| 3| 3| 9| 7| 0| 6| 3| 0| 2| 8| 3| 8| 9| 8| 4| 7| 6| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5MG/M3 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8|
| 5| 6| 7| 9| 0| 1| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X X X X X X X X X X X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 7| 5| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 9| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
0.5MG/M3 | 8| 8| 9| | L |
| 4| 5| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 52 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + I | 50 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 52 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
Leukemia Mononuclear | | 4 |
Peyer's Patch, Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
Leukemia Mononuclear | | 3 |
__________________________________________________________________________|____________|
Liver | + + + | 53 |
Hepatocellular Adenoma | | 2 |
Leukemia Mononuclear | X X X | 34 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 52 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
__________________________________________________________________________|____________|
Tooth | | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + | 53 |
Leukemia Mononuclear | | 8 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Leukemia Mononuclear | | 4 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Leukemia Mononuclear | | 4 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | | 9 |
Bilateral, Pheochromocytoma Benign | | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 88
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 7| 5| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 9| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
0.5MG/M3 | 8| 8| 9| | L |
| 4| 5| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Adenoma | | 4 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + | 48 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Leukemia Mononuclear | | 8 |
Pars Distalis, Adenoma | | 13 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + | 52 |
C-Cell, Adenoma | | 1 |
C-Cell, Carcinoma | | 2 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 4 |
Paraganglioma | | 1 |
Abdominal, Chondrosarcoma | | 1 |
Mediastinum, Leukemia Mononuclear | | 1 |
Thoracic, Chordoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + | 53 |
__________________________________________________________________________|____________|
Preputial Gland | + + + | 53 |
Adenoma | | 3 |
Carcinoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + | 53 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + | 53 |
__________________________________________________________________________|____________|
Testes | + + + | 53 |
Bilateral, Interstitial Cell, Adenoma| X X | 39 |
Interstitial Cell, Adenoma | X | 11 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Leukemia Mononuclear | X | 7 |
__________________________________________________________________________|____________|
Lymph Node | + | 12 |
Axillary, Leukemia Mononuclear | X | 2 |
Iliac, Leukemia Mononuclear | | 2 |
Inguinal, Leukemia Mononuclear | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 89
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 7| 5| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 9| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
0.5MG/M3 | 8| 8| 9| | L |
| 4| 5| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Leukemia Mononuclear | | 6 |
Renal, Leukemia Mononuclear | | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + | 52 |
Leukemia Mononuclear | X | 18 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 53 |
Leukemia Mononuclear | X | 14 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Leukemia Mononuclear | X | 15 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + | 50 |
Leukemia Mononuclear | X | 16 |
__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Leukemia Mononuclear | X X X | 38 |
__________________________________________________________________________|____________|
Thymus | + + + | 46 |
Leukemia Mononuclear | X | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + | 44 |
Fibroadenoma | | 1 |
Leukemia Mononuclear | | 1 |
__________________________________________________________________________|____________|
Skin | + + + | 53 |
Basal Cell Adenoma | | 1 |
Basal Cell Carcinoma | | 1 |
Fibroma | | 3 |
Squamous Cell Papilloma | | 2 |
Subcutaneous Tissue, Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + | 53 |
Meninges, Leukemia Mononuclear | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + | 53 |
__________________________________________________________________________|____________|
Lung | + + + | 53 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Chordoma, Metastatic, Tissue NOS | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 90
NTP Experiment-Test: 05122-05 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:55:11
__________________________________________________________________________________________________________________________________
| 7| 5| 7| | |
DAY ON TEST | 3| 3| 3| | |
| 3| 9| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
0.5MG/M3 | 8| 8| 9| | L |
| 4| 5| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Leukemia Mononuclear | X X X | 27 |
__________________________________________________________________________|____________|
Nose | + + + | 53 |
Nasopharyngeal Duct, Leukemia | | |
Mononuclear | | 1 |
__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Leukemia Mononuclear | X | 10 |
Renal Tubule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
Leukemia Mononuclear | | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Leukemia Mononuclear | X X X | 38 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 91
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