TDMS Study 05122-06 Pathology Tables
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
Core Animals
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 010101970
Lock Date: 04/19/94
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 6| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 9| 9| 3| 3| 3| 0| 1| 3| 3| 1| 0| 3| 2| 3| 3| 3| 3| 2| 9| 2|
| 8| 1| 0| 6| 3| 8| 8| 1| 6| 1| 0| 4| 0| 6| 4| 7| 2| 6| 0| 0| 5| 6| 5| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1|
MG/M3 | 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + I + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X |
__________________________________________________________________________|
Mesentery | + + + + |
Fibrosarcoma, Metastatic, Skin | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + M + + + + + + + + + + + +|
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Capsule, Adenoma | X |
Extra Adrenal Tissue, Lymphoma | |
Malignant | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 6| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 9| 9| 3| 3| 3| 0| 1| 3| 3| 1| 0| 3| 2| 3| 3| 3| 3| 2| 9| 2|
| 8| 1| 0| 6| 3| 8| 8| 1| 6| 1| 0| 4| 0| 6| 4| 7| 2| 6| 0| 0| 5| 6| 5| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1|
MG/M3 | 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + I + M + + M + + + + M + + I + + M + M + M|
Lymphoma Malignant | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Pars Distalis, Adenoma | X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Mediastinum, Fibrosarcoma, | |
Metastatic, Skin | |
Mediastinum, Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + I + + + + +|
Cystadenoma | X |
Granulosa Cell Tumor Benign | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X |
Periovarian Tissue, Lymphoma | |
Malignant | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leiomyoma | X |
Lymphoma Malignant | X |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node | + + + + |
Lymphoma Malignant | X |
Axillary, Fibrosarcoma, Metastatic, | |
Skin | |
Axillary, Lymphoma Malignant | X X X X |
Deep Cervical, Lymphoma Malignant | X |
Iliac, Fibrosarcoma, Metastatic, Skin| |
Iliac, Histiocytic Sarcoma | |
Iliac, Lymphoma Malignant | X X X X |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 6| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 9| 9| 3| 3| 3| 0| 1| 3| 3| 1| 0| 3| 2| 3| 3| 3| 3| 2| 9| 2|
| 8| 1| 0| 6| 3| 8| 8| 1| 6| 1| 0| 4| 0| 6| 4| 7| 2| 6| 0| 0| 5| 6| 5| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1|
MG/M3 | 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inguinal, Histiocytic Sarcoma | |
Inguinal, Lymphoma Malignant | X X X |
Pancreatic, Histiocytic Sarcoma | |
Pancreatic, Lymphoma Malignant | X X |
Renal, Histiocytic Sarcoma | |
Renal, Lymphoma Malignant | X X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + I + I I + + + + + + + + M + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + M +|
Lymphoma Malignant | X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M + M M + + I + M M M M M M M + + I M + + M +|
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basosquamous Tumor Malignant | X |
Lymphoma Malignant | X |
Subcutaneous Tissue, Fibrosarcoma | X X|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Fibrosarcoma, Metastatic, | |
Skin | |
__________________________________________________________________________|
Skeletal Muscle | + + |
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 6| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 9| 9| 3| 3| 3| 0| 1| 3| 3| 1| 0| 3| 2| 3| 3| 3| 3| 2| 9| 2|
| 8| 1| 0| 6| 3| 8| 8| 1| 6| 1| 0| 4| 0| 6| 4| 7| 2| 6| 0| 0| 5| 6| 5| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1|
MG/M3 | 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 1| 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Fibrosarcoma, Metastatic, Skin | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Urinary Bladder | + I + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 2| 3| 7| 7| 5| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 7| 5| 8| 3| 3| 3| 2| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 0|
| 3| 0| 0| 8| 4| 1| 4| 0| 7| 2| 1| 2| 7| 0| 2| 1| 0| 0| 6| 4| 0| 9| 1| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
MG/M3 | 3| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + I + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + I + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + M M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Mesentery | + + |
Fibrosarcoma, Metastatic, Skin | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Pancreas | M + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + M + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Capsule, Adenoma | |
Extra Adrenal Tissue, Lymphoma | |
Malignant | |
__________________________________________________________________________|
Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 2| 3| 7| 7| 5| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 7| 5| 8| 3| 3| 3| 2| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 0|
| 3| 0| 0| 8| 4| 1| 4| 0| 7| 2| 1| 2| 7| 0| 2| 1| 0| 0| 6| 4| 0| 9| 1| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
MG/M3 | 3| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + I + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | M + M M + M I + + M M M + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Pars Distalis, Adenoma | X X X|
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Mediastinum, Fibrosarcoma, | |
Metastatic, Skin | X |
Mediastinum, Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + + + + + I + + + + + + I + + +|
__________________________________________________________________________|
Ovary | + + + + + + + I + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Granulosa Cell Tumor Benign | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
Periovarian Tissue, Lymphoma | |
Malignant | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leiomyoma | |
Lymphoma Malignant | |
Polyp Stromal | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Lymphoma Malignant | |
Axillary, Fibrosarcoma, Metastatic, | |
Skin | X |
Axillary, Lymphoma Malignant | |
Deep Cervical, Lymphoma Malignant | |
Iliac, Fibrosarcoma, Metastatic, Skin| X |
Iliac, Histiocytic Sarcoma | X |
Iliac, Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 2| 3| 7| 7| 5| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 7| 5| 8| 3| 3| 3| 2| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 0|
| 3| 0| 0| 8| 4| 1| 4| 0| 7| 2| 1| 2| 7| 0| 2| 1| 0| 0| 6| 4| 0| 9| 1| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
MG/M3 | 3| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inguinal, Histiocytic Sarcoma | X |
Inguinal, Lymphoma Malignant | |
Pancreatic, Histiocytic Sarcoma | X |
Pancreatic, Lymphoma Malignant | X |
Renal, Histiocytic Sarcoma | X |
Renal, Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + + I M + + + + + + I + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + M + + + + + + + + + + + + + + + + I + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + M + + + + I + M + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + M + + + + M M M + + + + + + + M + M I I +|
Fibrosarcoma, Metastatic, Skin | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + I + + + +|
Fibrosarcoma, Metastatic, Skin | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basosquamous Tumor Malignant | |
Lymphoma Malignant | |
Subcutaneous Tissue, Fibrosarcoma | X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Fibrosarcoma, Metastatic, | |
Skin | X |
__________________________________________________________________________|
Skeletal Muscle | + + |
Fibrosarcoma, Metastatic, Skin | X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 2| 3| 7| 7| 5| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 7| 5| 8| 3| 3| 3| 2| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 0|
| 3| 0| 0| 8| 4| 1| 4| 0| 7| 2| 1| 2| 7| 0| 2| 1| 0| 0| 6| 4| 0| 9| 1| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
MG/M3 | 3| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | M + + + + + + + + + + + + I + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X X X |
Fibrosarcoma, Metastatic, Skin | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosarcoma, Metastatic, Skin | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 5| 9| 3| 8| 3| 3| | |
| 1| 3| 6| 3| 5| 5| 3| 5| 6| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/M3 | 5| 6| 0| 1| 2| 3| 4| 6| 7| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 59 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + I + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | M + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hepatocellular Carcinoma | X X | 7 |
Hepatocellular Adenoma | X X X X | 11 |
Hepatocellular Adenoma, Multiple | | 2 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 4 |
__________________________________________________________________________|____________|
Mesentery | + | 7 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 4 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Lymphoma Malignant | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 5| 9| 3| 8| 3| 3| | |
| 1| 3| 6| 3| 5| 5| 3| 5| 6| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/M3 | 5| 6| 0| 1| 2| 3| 4| 6| 7| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Lymphoma Malignant | | 1 |
Capsule, Adenoma | | 1 |
Extra Adrenal Tissue, Lymphoma | | |
Malignant | | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Adenoma | | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + M + M + I | 40 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Pars Distalis, Adenoma | X X X | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Lymphoma Malignant | | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 5 |
Mediastinum, Fibrosarcoma, | | |
Metastatic, Skin | | 1 |
Mediastinum, Lymphoma Malignant | | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 58 |
Cystadenoma | | 2 |
Granulosa Cell Tumor Benign | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 2 |
Periovarian Tissue, Lymphoma | | |
Malignant | | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
Leiomyoma | | 1 |
Lymphoma Malignant | | 1 |
Polyp Stromal | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 5| 9| 3| 8| 3| 3| | |
| 1| 3| 6| 3| 5| 5| 3| 5| 6| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/M3 | 5| 6| 0| 1| 2| 3| 4| 6| 7| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + | 11 |
Lymphoma Malignant | | 1 |
Axillary, Fibrosarcoma, Metastatic, | | |
Skin | | 1 |
Axillary, Lymphoma Malignant | | 4 |
Deep Cervical, Lymphoma Malignant | | 1 |
Iliac, Fibrosarcoma, Metastatic, Skin| | 1 |
Iliac, Histiocytic Sarcoma | | 1 |
Iliac, Lymphoma Malignant | | 5 |
Inguinal, Histiocytic Sarcoma | | 1 |
Inguinal, Lymphoma Malignant | | 3 |
Pancreatic, Histiocytic Sarcoma | | 1 |
Pancreatic, Lymphoma Malignant | | 3 |
Renal, Histiocytic Sarcoma | | 1 |
Renal, Lymphoma Malignant | | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + I I + + + | 50 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 55 |
Lymphoma Malignant | | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 56 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + M + M M M + I | 30 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Lymphoma Malignant | | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 5 |
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + | 57 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 5| 9| 3| 8| 3| 3| | |
| 1| 3| 6| 3| 5| 5| 3| 5| 6| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/M3 | 5| 6| 0| 1| 2| 3| 4| 6| 7| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Carcinoma | X | 2 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Basosquamous Tumor Malignant | | 1 |
Lymphoma Malignant | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Maxilla, Fibrosarcoma, Metastatic, | | |
Skin | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 4 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Lymphoma Malignant | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 58 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | | 3 |
Alveolar/Bronchiolar Carcinoma | | 4 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 5| 9| 3| 8| 3| 3| | |
| 1| 3| 6| 3| 5| 5| 3| 5| 6| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/M3 | 5| 6| 0| 1| 2| 3| 4| 6| 7| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 0| | |
DAY ON TEST | 3| | |
| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 1| | A |
0.0MG/M3 | 1| | L |
LUNG TOX | 7| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 1 |
__________________________________________________________________________|____________|
Gallbladder | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
__________________________________________________________________________|____________|
Liver | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M | |
__________________________________________________________________________|____________|
Pituitary Gland | + | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
__________________________________________________________________________|____________|
Ovary | + | 1 |
__________________________________________________________________________|____________|
Uterus | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 0| | |
DAY ON TEST | 3| | |
| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE FEMALE | 0| | T |
ANIMAL ID | 1| | A |
0.0MG/M3 | 1| | L |
LUNG TOX | 7| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spleen | + | 1 |
__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | M | |
__________________________________________________________________________|____________|
Lung | + | 1 |
__________________________________________________________________________|____________|
Nose | + | 1 |
__________________________________________________________________________|____________|
Trachea | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 0| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 6| 3| 3| 7| 3| 1| 3| 3| 6| 4| 3| 3| 3|
| 5| 7| 1| 3| 1| 0| 8| 3| 0| 2| 1| 4| 1| 3| 6| 9| 1| 4| 0| 1| 6| 9| 3| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/M3 | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A + + + + + + + + + + + + + A + + + +|
Wall, Cholangiocarcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Anus, Squamous Cell Papilloma | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Lymphatic, Cholangiocarcinoma, | |
Metastatic, Liver | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Histiocytic Sarcoma | |
Serosa, Cholangiocarcinoma, | |
Metastatic, Liver | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + A + + + +|
Cholangiocarcinoma | |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Medulla | |
__________________________________________________________________________|
Mesentery | + + |
Cholangiocarcinoma, Metastatic, Liver| |
Lymphoma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +|
Cholangiocarcinoma, Metastatic, Liver| |
Lymphoma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + A + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | |
Squamous Cell Papilloma | X |
Serosa, Cholangiocarcinoma, | |
Metastatic, Liver | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 0| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 6| 3| 3| 7| 3| 1| 3| 3| 6| 4| 3| 3| 3|
| 5| 7| 1| 3| 1| 0| 8| 3| 0| 2| 1| 4| 1| 3| 6| 9| 1| 4| 0| 1| 6| 9| 3| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/M3 | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Neoplasm NOS, Metastatic, Uncertain | |
Primary Site | |
Epicardium, Cholangiocarcinoma, | |
Metastatic, Liver | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + A I + + +|
Extra Adrenal Tissue, | |
Cholangiocarcinoma, Metastatic, | |
Liver | |
Extra Adrenal Tissue, Lymphoma | |
Malignant | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + A I + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + I + + + + + + + + + + A + + + +|
Adenoma | |
Cholangiocarcinoma, Metastatic, Liver| |
__________________________________________________________________________|
Parathyroid Gland | M I + + + + + + + + M + + + + + + + + + M M M + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + I + + + + + + + + + + + + + A + + + +|
Pars Distalis, Adenoma | X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma, Multiple | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + +|
Abdominal, Lymphoma Malignant | |
Mediastinum, Cholangiocarcinoma, | |
Metastatic, Liver | |
Mediastinum, Lymphoma Malignant | |
Thoracic, Neoplasm NOS, Metastatic, | |
Uncertain Primary Site | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + M + + + + + + + + + + + + I + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + A + + M +|
Cystadenoma | |
Granulosa Cell Tumor Malignant | |
Lymphoma Malignant | X X |
Bilateral, Cholangiocarcinoma, | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 0| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 6| 3| 3| 7| 3| 1| 3| 3| 6| 4| 3| 3| 3|
| 5| 7| 1| 3| 1| 0| 8| 3| 0| 2| 1| 4| 1| 3| 6| 9| 1| 4| 0| 1| 6| 9| 3| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/M3 | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Metastatic, Liver | |
Periovarian Tissue, Lymphoma | |
Malignant | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma, Metastatic, Liver| |
Fibroma | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
Polyp Stromal | X X |
Polyp Stromal, Multiple | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node | + + + + |
Axillary, Lymphoma Malignant | X |
Iliac, Histiocytic Sarcoma | |
Iliac, Lymphoma Malignant | X X |
Inguinal, Histiocytic Sarcoma | |
Inguinal, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant | X X |
Renal, Histiocytic Sarcoma | |
Renal, Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + I + + + + + + + + + M + + A + + + +|
Cholangiocarcinoma, Metastatic, Liver| |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X |
Neoplasm NOS, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + I + + + + A + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + A + + + + + + I + + + + + + A + + + M|
Cholangiocarcinoma, Metastatic, Liver| |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + M + + + I + M M M + M + M M + M M M M +|
Cholangiocarcinoma, Metastatic, Liver| |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X |
Neoplasm NOS, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 0| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 6| 3| 3| 7| 3| 1| 3| 3| 6| 4| 3| 3| 3|
| 5| 7| 1| 3| 1| 0| 8| 3| 0| 2| 1| 4| 1| 3| 6| 9| 1| 4| 0| 1| 6| 9| 3| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/M3 | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X |
Capsule, Cholangiocarcinoma, | |
Metastatic, Liver | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + I + + + I + + + A + + + +|
Cholangiocarcinoma, Metastatic, Liver| |
Lymphoma Malignant | X |
Neoplasm NOS, Metastatic, Uncertain | |
Primary Site | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + A I + + +|
Carcinoma | X |
Fibroadenoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
Subcutaneous Tissue, Hemangioma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Neoplasm NOS, Metastatic, Uncertain | |
Primary Site | |
Abdominal, Cholangiocarcinoma, | |
Metastatic, Liver | |
Diaphragm, Cholangiocarcinoma, | |
Metastatic, Liver | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + I + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X X X |
Cholangiocarcinoma, Metastatic, Liver| |
Hepatocellular Carcinoma, Metastatic | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 0| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 6| 3| 3| 7| 3| 1| 3| 3| 6| 4| 3| 3| 3|
| 5| 7| 1| 3| 1| 0| 8| 3| 0| 2| 1| 4| 1| 3| 6| 9| 1| 4| 0| 1| 6| 9| 3| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/M3 | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Neoplasm NOS, Metastatic, Uncertain | |
Primary Site | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
Perirenal Tissue, Cholangiocarcinoma,| |
Metastatic, Liver | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Cholangiocarcinoma, | |
Metastatic, Liver | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 3| 5|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 7| 0| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 8|
| 5| 2| 3| 1| 3| 0| 8| 3| 1| 6| 9| 0| 2| 3| 0| 4| 0| 1| 3| 6| 1| 0| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
0.25 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/M3 | 3| 5| 6| 7| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + M M|
Wall, Cholangiocarcinoma, Metastatic,| |
Liver | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + + + + A|
Anus, Squamous Cell Papilloma | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Lymphatic, Cholangiocarcinoma, | |
Metastatic, Liver | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + M + + + + + A|
Histiocytic Sarcoma | X |
Serosa, Cholangiocarcinoma, | |
Metastatic, Liver | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | X |
Hepatocellular Carcinoma | X X X X|
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | X X X X X X X X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | X X |
Lymphoma Malignant | |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Medulla | |
__________________________________________________________________________|
Mesentery | + + |
Cholangiocarcinoma, Metastatic, Liver| X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
Cholangiocarcinoma, Metastatic, Liver| X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
Squamous Cell Papilloma | |
Serosa, Cholangiocarcinoma, | |
Metastatic, Liver | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 3| 5|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 7| 0| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 8|
| 5| 2| 3| 1| 3| 0| 8| 3| 1| 6| 9| 0| 2| 3| 0| 4| 0| 1| 3| 6| 1| 0| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
0.25 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/M3 | 3| 5| 6| 7| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Neoplasm NOS, Metastatic, Uncertain | |
Primary Site | X|
Epicardium, Cholangiocarcinoma, | |
Metastatic, Liver | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Extra Adrenal Tissue, | |
Cholangiocarcinoma, Metastatic, | |
Liver | X |
Extra Adrenal Tissue, Lymphoma | |
Malignant | X X X |
__________________________________________________________________________|
Adrenal Medulla | + + + I + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
Adenoma | |
Cholangiocarcinoma, Metastatic, Liver| X |
__________________________________________________________________________|
Parathyroid Gland | M M + + M + + + + + + + + + + M + + + + + M + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma, Multiple | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + + +|
Abdominal, Lymphoma Malignant | X |
Mediastinum, Cholangiocarcinoma, | |
Metastatic, Liver | X |
Mediastinum, Lymphoma Malignant | X X |
Thoracic, Neoplasm NOS, Metastatic, | |
Uncertain Primary Site | X|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X |
Granulosa Cell Tumor Malignant | X |
Lymphoma Malignant | |
Bilateral, Cholangiocarcinoma, | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 3| 5|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 7| 0| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 8|
| 5| 2| 3| 1| 3| 0| 8| 3| 1| 6| 9| 0| 2| 3| 0| 4| 0| 1| 3| 6| 1| 0| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
0.25 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/M3 | 3| 5| 6| 7| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 4| 5| 6|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Metastatic, Liver | X |
Periovarian Tissue, Lymphoma | |
Malignant | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma, Metastatic, Liver| X |
Fibroma | |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
Polyp Stromal | |
Polyp Stromal, Multiple | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node | + + + + + |
Axillary, Lymphoma Malignant | |
Iliac, Histiocytic Sarcoma | X |
Iliac, Lymphoma Malignant | X |
Inguinal, Histiocytic Sarcoma | X |
Inguinal, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant | X |
Renal, Histiocytic Sarcoma | X |
Renal, Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + I + + + + + +|
Cholangiocarcinoma, Metastatic, Liver| X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X X |
Neoplasm NOS, Metastatic, Uncertain | |
Primary Site | X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + I + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + A + + + + I + + + A|
Cholangiocarcinoma, Metastatic, Liver| X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M M + M + + + M + M M + + + + M M M M M M + +|
Cholangiocarcinoma, Metastatic, Liver| X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
Neoplasm NOS, Metastatic, Uncertain | |
Primary Site | X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 3| 5|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 7| 0| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 8|
| 5| 2| 3| 1| 3| 0| 8| 3| 1| 6| 9| 0| 2| 3| 0| 4| 0| 1| 3| 6| 1| 0| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
0.25 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/M3 | 3| 5| 6| 7| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Histiocytic Sarcoma | X X |
Lymphoma Malignant | X |
Capsule, Cholangiocarcinoma, | |
Metastatic, Liver | X |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + M + + + + + + + + + + + +|
Cholangiocarcinoma, Metastatic, Liver| X |
Lymphoma Malignant | X X |
Neoplasm NOS, Metastatic, Uncertain | |
Primary Site | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Fibroadenoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
Subcutaneous Tissue, Hemangioma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + +|
Neoplasm NOS, Metastatic, Uncertain | |
Primary Site | X|
Abdominal, Cholangiocarcinoma, | |
Metastatic, Liver | X |
Diaphragm, Cholangiocarcinoma, | |
Metastatic, Liver | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + M + + + + + + + + + + + + + + + + I +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Cholangiocarcinoma, Metastatic, Liver| X |
Hepatocellular Carcinoma, Metastatic | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 3| 5|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 7| 0| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 8|
| 5| 2| 3| 1| 3| 0| 8| 3| 1| 6| 9| 0| 2| 3| 0| 4| 0| 1| 3| 6| 1| 0| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
0.25 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/M3 | 3| 5| 6| 7| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 4| 5| 6|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Neoplasm NOS, Metastatic, Uncertain | |
Primary Site | X|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
Perirenal Tissue, Cholangiocarcinoma,| |
Metastatic, Liver | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Cholangiocarcinoma, | |
Metastatic, Liver | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
Lymphoma Malignant | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 8| 7| 3| 3| 3| 1| 3| 3| 3| 7| | |
| 3| 5| 3| 6| 0| 1| 6| 0| 3| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25 | 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/M3 | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + M | 55 |
Wall, Cholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
Anus, Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A | 57 |
Lymphatic, Cholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
Histiocytic Sarcoma | | 1 |
Serosa, Cholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 58 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Cholangiocarcinoma | | 1 |
Hepatocellular Carcinoma | | 9 |
Hepatocellular Carcinoma, Multiple | X | 5 |
Hepatocellular Adenoma | X | 13 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | | 2 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Medulla | X | 1 |
__________________________________________________________________________|____________|
Mesentery | | 4 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 8| 7| 3| 3| 3| 1| 3| 3| 3| 7| | |
| 3| 5| 3| 6| 0| 1| 6| 0| 3| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25 | 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/M3 | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Squamous Cell Papilloma | | 1 |
Serosa, Cholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Tooth | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | M + + + + + + + + + | 59 |
Neoplasm NOS, Metastatic, Uncertain | | |
Primary Site | | 1 |
Epicardium, Cholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
Extra Adrenal Tissue, | | |
Cholangiocarcinoma, Metastatic, | | |
Liver | | 1 |
Extra Adrenal Tissue, Lymphoma | | |
Malignant | | 4 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 57 |
Pheochromocytoma Malignant | X | 1 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + M + | 56 |
Adenoma | X | 1 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M + + + + M | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 56 |
Pars Distalis, Adenoma | X | 9 |
__________________________________________________________________________|____________|
Thyroid Gland | M + + + + + + + + + | 59 |
Follicular Cell, Adenoma, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 8 |
Abdominal, Lymphoma Malignant | | 1 |
Mediastinum, Cholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
Mediastinum, Lymphoma Malignant | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 8| 7| 3| 3| 3| 1| 3| 3| 3| 7| | |
| 3| 5| 3| 6| 0| 1| 6| 0| 3| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25 | 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/M3 | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
Thoracic, Neoplasm NOS, Metastatic, | | |
Uncertain Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 58 |
Cystadenoma | | 1 |
Granulosa Cell Tumor Malignant | | 1 |
Lymphoma Malignant | | 2 |
Bilateral, Cholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
Fibroma | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
Polyp Stromal | | 2 |
Polyp Stromal, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + | 11 |
Axillary, Lymphoma Malignant | | 1 |
Iliac, Histiocytic Sarcoma | | 1 |
Iliac, Lymphoma Malignant | X | 4 |
Inguinal, Histiocytic Sarcoma | | 1 |
Inguinal, Lymphoma Malignant | | 1 |
Pancreatic, Lymphoma Malignant | X | 4 |
Renal, Histiocytic Sarcoma | | 1 |
Renal, Lymphoma Malignant | X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + + + + | 54 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X | 8 |
Neoplasm NOS, Metastatic, Uncertain | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 8| 7| 3| 3| 3| 1| 3| 3| 3| 7| | |
| 3| 5| 3| 6| 0| 1| 6| 0| 3| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25 | 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/M3 | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + | 56 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + I | 52 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M + M + M + + M | 28 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X | 6 |
Neoplasm NOS, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | X | 6 |
Capsule, Cholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + | 54 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
Lymphoma Malignant | X | 4 |
Neoplasm NOS, Metastatic, Uncertain | | |
Primary Site | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 58 |
Carcinoma | | 1 |
Fibroadenoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Skin | + + + I + + + + + + | 59 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Hemangioma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
Neoplasm NOS, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 8| 7| 3| 3| 3| 1| 3| 3| 3| 7| | |
| 3| 5| 3| 6| 0| 1| 6| 0| 3| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25 | 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/M3 | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Abdominal, Cholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
Diaphragm, Cholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | M + + + + + + + + + | 56 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | X | 3 |
Alveolar/Bronchiolar Carcinoma | | 3 |
Cholangiocarcinoma, Metastatic, Liver| | 1 |
Hepatocellular Carcinoma, Metastatic | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 2 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 2 |
Neoplasm NOS, Metastatic, Uncertain | | |
Primary Site | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
Perirenal Tissue, Cholangiocarcinoma,| | |
Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Serosa, Cholangiocarcinoma, | | |
Metastatic, Liver | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 8| 7| 3| 3| 3| 1| 3| 3| 3| 7| | |
| 3| 5| 3| 6| 0| 1| 6| 0| 3| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25 | 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/M3 | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Histiocytic Sarcoma | | 4 |
Lymphoma Malignant | X | 12 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3|
| 2| 6| 1| 3| 0| 0| 1| 2| 0| 0| 0| 2| 2| 0| 0| 4| 2| 6| 6| 2| 7| 0| 3| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + M + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + M +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + M M + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X X |
Lymphoma Malignant | |
__________________________________________________________________________|
Mesentery | + |
Carcinoma, Metastatic, Lung | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Carcinoma, Metastatic, Lung | |
Lymphoma Malignant | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Extra Adrenal Tissue, Carcinoma, | |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3|
| 2| 6| 1| 3| 0| 0| 1| 2| 0| 0| 0| 2| 2| 0| 0| 4| 2| 6| 6| 2| 7| 0| 3| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Metastatic, Lung | |
Extra Adrenal Tissue, Histiocytic | |
Sarcoma | X |
Extra Adrenal Tissue, Lymphoma | |
Malignant | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + + + + + M + + M + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Pars Distalis, Adenoma | X X |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Fibrosarcoma, Metastatic, Skin | X |
Mediastinum, Carcinoma, Metastatic, | |
Lung | |
Thoracic, Carcinoma, Metastatic, Lung| |
Thoracic, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + + + + I + + M + M + M + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Histiocytic Sarcoma | X |
Leiomyosarcoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Vagina | + |
Fibroma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node | + + + + |
Axillary, Carcinoma, Metastatic, Lung| |
Axillary, Lymphoma Malignant | |
Deep Cervical, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3|
| 2| 6| 1| 3| 0| 0| 1| 2| 0| 0| 0| 2| 2| 0| 0| 4| 2| 6| 6| 2| 7| 0| 3| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Histiocytic Sarcoma | X |
Iliac, Lymphoma Malignant | X |
Inguinal, Carcinoma, Metastatic, Lung| |
Inguinal, Lymphoma Malignant | |
Pancreatic, Carcinoma, Metastatic, | |
Lung | |
Pancreatic, Histiocytic Sarcoma | X |
Pancreatic, Lymphoma Malignant | |
Pancreatic, Neoplasm NOS | |
Popliteal, Lymphoma Malignant | |
Renal, Histiocytic Sarcoma | X X |
Renal, Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + I + + + +|
Carcinoma, Metastatic, Lung | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | I + + + + + + + + + + + + + + + I + + + + + + + +|
Carcinoma, Metastatic, Lung | |
Histiocytic Sarcoma | X X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + I + + + + M M M M + + M + M M + + + + + M +|
Carcinoma, Metastatic, Lung | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Thymus | + + + M + M + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + I|
Subcutaneous Tissue, Carcinoma, | |
Metastatic, Lung | |
Subcutaneous Tissue, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3|
| 2| 6| 1| 3| 0| 0| 1| 2| 0| 0| 0| 2| 2| 0| 0| 4| 2| 6| 6| 2| 7| 0| 3| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | |
Lymphoma Malignant | |
Abdominal, Carcinoma, Metastatic, | |
Lung | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Lymphoma Malignant | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X X |
__________________________________________________________________________|
Lacrimal Gland | |
__________________________________________________________________________|
Zymbal's Gland | |
Carcinoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 6|
DAY ON TEST | 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 1| 6| 3| 3| 8|
| 2| 6| 9| 2| 1| 6| 1| 3| 0| 2| 3| 6| 6| 1| 6| 9| 3| 4| 6| 1| 4| 7| 6| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
MG/M3 | 9| 0| 1| 2| 5| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + I + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + M + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + I + + + + + + + I + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Adenocarcinoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A M + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X |
__________________________________________________________________________|
Mesentery | + + + |
Carcinoma, Metastatic, Lung | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Extra Adrenal Tissue, Carcinoma, | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 6|
DAY ON TEST | 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 1| 6| 3| 3| 8|
| 2| 6| 9| 2| 1| 6| 1| 3| 0| 2| 3| 6| 6| 1| 6| 9| 3| 4| 6| 1| 4| 7| 6| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
MG/M3 | 9| 0| 1| 2| 5| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Metastatic, Lung | X |
Extra Adrenal Tissue, Histiocytic | |
Sarcoma | |
Extra Adrenal Tissue, Lymphoma | |
Malignant | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + I + + + +|
Adenoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + + + + + + + + + + M + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
Fibrosarcoma, Metastatic, Skin | |
Mediastinum, Carcinoma, Metastatic, | |
Lung | X |
Thoracic, Carcinoma, Metastatic, Lung| X |
Thoracic, Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + M + + + + + + + + + M + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Histiocytic Sarcoma | |
Leiomyosarcoma | X|
Lymphoma Malignant | |
__________________________________________________________________________|
Vagina | |
Fibroma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Axillary, Carcinoma, Metastatic, Lung| X |
Axillary, Lymphoma Malignant | |
Deep Cervical, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 6|
DAY ON TEST | 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 1| 6| 3| 3| 8|
| 2| 6| 9| 2| 1| 6| 1| 3| 0| 2| 3| 6| 6| 1| 6| 9| 3| 4| 6| 1| 4| 7| 6| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
MG/M3 | 9| 0| 1| 2| 5| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Histiocytic Sarcoma | |
Iliac, Lymphoma Malignant | X X X X |
Inguinal, Carcinoma, Metastatic, Lung| X |
Inguinal, Lymphoma Malignant | X X |
Pancreatic, Carcinoma, Metastatic, | |
Lung | X |
Pancreatic, Histiocytic Sarcoma | |
Pancreatic, Lymphoma Malignant | X X |
Pancreatic, Neoplasm NOS | |
Popliteal, Lymphoma Malignant | |
Renal, Histiocytic Sarcoma | |
Renal, Lymphoma Malignant | X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + M + + + + + + + + +|
Carcinoma, Metastatic, Lung | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +|
Carcinoma, Metastatic, Lung | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + M + + M + + + M + + + I M M M M + + M + +|
Carcinoma, Metastatic, Lung | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + M + + + + M +|
Lymphoma Malignant | X X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Carcinoma, | |
Metastatic, Lung | X |
Subcutaneous Tissue, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Maxilla, Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 6|
DAY ON TEST | 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 1| 6| 3| 3| 8|
| 2| 6| 9| 2| 1| 6| 1| 3| 0| 2| 3| 6| 6| 1| 6| 9| 3| 4| 6| 1| 4| 7| 6| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
MG/M3 | 9| 0| 1| 2| 5| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Skeletal Muscle | + + + |
Lymphoma Malignant | X X |
Abdominal, Carcinoma, Metastatic, | |
Lung | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + I + + + + + + + I + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X X X X X|
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
__________________________________________________________________________|
Lacrimal Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| | |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 2| 1| 3| | |
| 1| 6| 2| 0| 1| 6| 3| 9| 4| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/M3 | 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + + + | 57 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + I + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
Adenocarcinoma | | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hepatocellular Carcinoma | X X | 5 |
Hepatocellular Adenoma | X X X | 10 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | X | 5 |
__________________________________________________________________________|____________|
Mesentery | | 4 |
Carcinoma, Metastatic, Lung | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Lymphoma Malignant | X | 4 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Carcinoma, Metastatic, Lung | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Carcinoma, Metastatic, Lung | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 41
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| | |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 2| 1| 3| | |
| 1| 6| 2| 0| 1| 6| 3| 9| 4| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/M3 | 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Lymphoma Malignant | X | 1 |
Extra Adrenal Tissue, Carcinoma, | | |
Metastatic, Lung | | 1 |
Extra Adrenal Tissue, Histiocytic | | |
Sarcoma | | 1 |
Extra Adrenal Tissue, Lymphoma | | |
Malignant | | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Adenoma | | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Adenoma | X | 5 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 4 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Mediastinum, Carcinoma, Metastatic, | | |
Lung | | 1 |
Thoracic, Carcinoma, Metastatic, Lung| | 1 |
Thoracic, Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hemangioma | | 1 |
Histiocytic Sarcoma | | 1 |
Leiomyosarcoma | | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 42
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| | |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 2| 1| 3| | |
| 1| 6| 2| 0| 1| 6| 3| 9| 4| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/M3 | 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Vagina | | 1 |
Fibroma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + | 13 |
Axillary, Carcinoma, Metastatic, Lung| | 1 |
Axillary, Lymphoma Malignant | X | 1 |
Deep Cervical, Lymphoma Malignant | X | 1 |
Iliac, Histiocytic Sarcoma | | 1 |
Iliac, Lymphoma Malignant | X | 6 |
Inguinal, Carcinoma, Metastatic, Lung| | 1 |
Inguinal, Lymphoma Malignant | X | 3 |
Pancreatic, Carcinoma, Metastatic, | | |
Lung | | 1 |
Pancreatic, Histiocytic Sarcoma | | 1 |
Pancreatic, Lymphoma Malignant | X | 3 |
Pancreatic, Neoplasm NOS | X | 1 |
Popliteal, Lymphoma Malignant | X | 1 |
Renal, Histiocytic Sarcoma | | 2 |
Renal, Lymphoma Malignant | X X | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 58 |
Carcinoma, Metastatic, Lung | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | X X | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M | 56 |
Carcinoma, Metastatic, Lung | | 1 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | X | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M + I M M M + + | 33 |
Carcinoma, Metastatic, Lung | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X | 6 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| | |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 2| 1| 3| | |
| 1| 6| 2| 0| 1| 6| 3| 9| 4| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/M3 | 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant | X X | 9 |
__________________________________________________________________________|____________|
Thymus | + + + + I + + + + + | 54 |
Lymphoma Malignant | X | 6 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Subcutaneous Tissue, Carcinoma, | | |
Metastatic, Lung | | 1 |
Subcutaneous Tissue, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Maxilla, Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
Lymphoma Malignant | | 2 |
Abdominal, Carcinoma, Metastatic, | | |
Lung | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + M + | 59 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Carcinoma | X | 8 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 1 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
Adenoma | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| | |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 2| 1| 3| | |
| 1| 6| 2| 0| 1| 6| 3| 9| 4| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/M3 | 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | X | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | A + + + + + + + + + | 58 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | X X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 2| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 1| 5| 3| 3| 3| 6| 3| 8| 3| 3| 3| 3| 2| 6| 3|
| 2| 2| 3| 9| 6| 4| 2| 2| 2| 2| 3| 7| 6| 6| 2| 1| 0| 1| 2| 3| 2| 1| 8| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
MG/M3 | 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + I M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M M + M + I I + + + + + + I + M + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | |
Hemangiosarcoma | |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
Osteosarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Mesentery | + + + |
Fibrosarcoma, Metastatic, Skeletal | |
Muscle | |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Lymphoma Malignant | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Lymphoma Malignant | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Extra Adrenal Tissue, Lymphoma | |
Malignant | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + M + + + + + + + + + + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + I + + + + + + + I +|
Pars Distalis, Adenoma | X |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 2| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 1| 5| 3| 3| 3| 6| 3| 8| 3| 3| 3| 3| 2| 6| 3|
| 2| 2| 3| 9| 6| 4| 2| 2| 2| 2| 3| 7| 6| 6| 2| 1| 0| 1| 2| 3| 2| 1| 8| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
MG/M3 | 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Mediastinum, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | |
Tubulostromal Adenoma | |
Periovarian Tissue, Histiocytic | |
Sarcoma | |
Periovarian Tissue, Lymphoma | |
Malignant | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node | + + + + |
Axillary, Histiocytic Sarcoma | |
Axillary, Lymphoma Malignant | |
Iliac, Histiocytic Sarcoma | |
Iliac, Lymphoma Malignant | |
Inguinal, Lymphoma Malignant | |
Pancreatic, Histiocytic Sarcoma | |
Pancreatic, Lymphoma Malignant | |
Renal, Histiocytic Sarcoma | |
Renal, Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Bronchial | I + + + + + + + + + + + + M + I + + + + + + + + +|
Carcinoma, Metastatic, Lung | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
Neoplasm NOS, Metastatic, Lung | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + M + + + M|
Carcinoma, Metastatic | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
Mast Cell Tumor Benign | X |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 2| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 1| 5| 3| 3| 3| 6| 3| 8| 3| 3| 3| 3| 2| 6| 3|
| 2| 2| 3| 9| 6| 4| 2| 2| 2| 2| 3| 7| 6| 6| 2| 1| 0| 1| 2| 3| 2| 1| 8| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
MG/M3 | 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + M + M + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + I I M + I + + + M M + I I M M M M + + I + M M|
Carcinoma, Metastatic, Lung | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Thymus | + + + I + + + + + + + + + M + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | |
Subcutaneous Tissue, Hemangioma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Osteosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + I + + + + + + + + + + I + + + + + +|
Carcinoma, Metastatic, Lung | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X |
Carcinoma | |
Fibrosarcoma, Metastatic, Skin | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
Neoplasm NOS | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 2| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 1| 5| 3| 3| 3| 6| 3| 8| 3| 3| 3| 3| 2| 6| 3|
| 2| 2| 3| 9| 6| 4| 2| 2| 2| 2| 3| 7| 6| 6| 2| 1| 0| 1| 2| 3| 2| 1| 8| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
MG/M3 | 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 3| 7| 7| 6| 7| 7| 7| 7| 3| 6| 5| 5| 5| 6| 3| 7| 7| 5| 6| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 6| 3| 3| 3| 3| 7| 0| 6| 1| 2| 9| 1| 3| 3| 7| 0| 3| 9| 3| 3| 3| 3|
| 3| 0| 3| 9| 0| 1| 6| 3| 0| 1| 2| 6| 1| 8| 0| 1| 1| 1| 4| 6| 6| 0| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
MG/M3 | 3| 4| 5| 6| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + A A M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + I + + + + + + + + + + + + + + + + + I I + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | X |
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X X X X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | X X |
Lymphoma Malignant | X |
Osteosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Mesentery | |
Fibrosarcoma, Metastatic, Skeletal | |
Muscle | |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Lymphoma Malignant | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Lymphoma Malignant | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Extra Adrenal Tissue, Lymphoma | |
Malignant | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M M M M + + + + M + + + I + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 3| 7| 7| 6| 7| 7| 7| 7| 3| 6| 5| 5| 5| 6| 3| 7| 7| 5| 6| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 6| 3| 3| 3| 3| 7| 0| 6| 1| 2| 9| 1| 3| 3| 7| 0| 3| 9| 3| 3| 3| 3|
| 3| 0| 3| 9| 0| 1| 6| 3| 0| 1| 2| 6| 1| 8| 0| 1| 1| 1| 4| 6| 6| 0| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
MG/M3 | 3| 4| 5| 6| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | X |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Mediastinum, Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + M + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | |
Tubulostromal Adenoma | |
Periovarian Tissue, Histiocytic | |
Sarcoma | |
Periovarian Tissue, Lymphoma | |
Malignant | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Polyp Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Axillary, Histiocytic Sarcoma | X |
Axillary, Lymphoma Malignant | X |
Iliac, Histiocytic Sarcoma | X |
Iliac, Lymphoma Malignant | X X X |
Inguinal, Lymphoma Malignant | X X |
Pancreatic, Histiocytic Sarcoma | X X |
Pancreatic, Lymphoma Malignant | X |
Renal, Histiocytic Sarcoma | X |
Renal, Lymphoma Malignant | X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + M + + +|
Carcinoma, Metastatic, Lung | X |
Histiocytic Sarcoma | X X |
Lymphoma Malignant | X X X X |
Neoplasm NOS, Metastatic, Lung | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
Carcinoma, Metastatic | |
Histiocytic Sarcoma | X X |
Lymphoma Malignant | X X X |
Mast Cell Tumor Benign | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 3| 7| 7| 6| 7| 7| 7| 7| 3| 6| 5| 5| 5| 6| 3| 7| 7| 5| 6| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 6| 3| 3| 3| 3| 7| 0| 6| 1| 2| 9| 1| 3| 3| 7| 0| 3| 9| 3| 3| 3| 3|
| 3| 0| 3| 9| 0| 1| 6| 3| 0| 1| 2| 6| 1| 8| 0| 1| 1| 1| 4| 6| 6| 0| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
MG/M3 | 3| 4| 5| 6| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + M + + M + + + + + + + + + + M + + +|
Histiocytic Sarcoma | X X |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + + I M + M M M + M I M M M + + M M + + M M M|
Carcinoma, Metastatic, Lung | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | X |
Histiocytic Sarcoma | X X |
Lymphoma Malignant | X X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Fibrosarcoma | X |
Subcutaneous Tissue, Hemangioma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + I + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | X |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | |
Carcinoma | X |
Fibrosarcoma, Metastatic, Skin | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
Neoplasm NOS | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 3| 7| 7| 6| 7| 7| 7| 7| 3| 6| 5| 5| 5| 6| 3| 7| 7| 5| 6| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 6| 3| 3| 3| 3| 7| 0| 6| 1| 2| 9| 1| 3| 3| 7| 0| 3| 9| 3| 3| 3| 3|
| 3| 0| 3| 9| 0| 1| 6| 3| 0| 1| 2| 6| 1| 8| 0| 1| 1| 1| 4| 6| 6| 0| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
MG/M3 | 3| 4| 5| 6| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Lung | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + M + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X X X |
Lymphoma Malignant | X X X X |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 7| 3| 3| 5| 6| 3| 3| 3| 3| | |
| 0| 5| 6| 2| 9| 3| 1| 3| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
1.0 | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| | L |
MG/M3 | 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | I M + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Carcinoma, Metastatic, Lung | | 1 |
Hemangiosarcoma | X | 1 |
Hepatocellular Carcinoma | X | 10 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X X X | 8 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | X | 3 |
Lymphoma Malignant | | 1 |
Osteosarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Fibrosarcoma, Metastatic, Skeletal | | |
Muscle | X | 1 |
Histiocytic Sarcoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Serosa, Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + M + + | 59 |
Serosa, Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Extra Adrenal Tissue, Lymphoma | | |
Malignant | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 54
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 7| 3| 3| 5| 6| 3| 3| 3| 3| | |
| 0| 5| 6| 2| 9| 3| 1| 3| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
1.0 | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| | L |
MG/M3 | 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 57 |
Pars Distalis, Adenoma | | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Carcinoma, Metastatic, Lung | | 1 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 3 |
Mediastinum, Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + I + + + M + | 58 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Granulosa Cell Tumor Benign | X | 1 |
Tubulostromal Adenoma | X | 1 |
Periovarian Tissue, Histiocytic | | |
Sarcoma | X | 1 |
Periovarian Tissue, Lymphoma | | |
Malignant | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | X | 2 |
Polyp Stromal | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 13 |
Axillary, Histiocytic Sarcoma | | 1 |
Axillary, Lymphoma Malignant | | 1 |
Iliac, Histiocytic Sarcoma | | 1 |
Iliac, Lymphoma Malignant | | 3 |
Inguinal, Lymphoma Malignant | | 2 |
Pancreatic, Histiocytic Sarcoma | X | 3 |
Pancreatic, Lymphoma Malignant | | 1 |
Renal, Histiocytic Sarcoma | | 1 |
Renal, Lymphoma Malignant | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 7| 3| 3| 5| 6| 3| 3| 3| 3| | |
| 0| 5| 6| 2| 9| 3| 1| 3| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
1.0 | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| | L |
MG/M3 | 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 56 |
Carcinoma, Metastatic, Lung | | 1 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | X | 6 |
Neoplasm NOS, Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + + | 55 |
Carcinoma, Metastatic | | 1 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | | 3 |
Mast Cell Tumor Benign | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + + + + | 51 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | I + M + M M + M + M | 22 |
Carcinoma, Metastatic, Lung | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + | 56 |
Carcinoma, Metastatic, Lung | | 1 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Carcinoma | | 1 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Fibrosarcoma | X | 2 |
Subcutaneous Tissue, Hemangioma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Vertebra, Osteosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 7| 3| 3| 5| 6| 3| 3| 3| 3| | |
| 0| 5| 6| 2| 9| 3| 1| 3| 3| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
1.0 | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| | L |
MG/M3 | 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Larynx | I + + + + + + + + + | 56 |
Carcinoma, Metastatic, Lung | | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Carcinoma | | 1 |
Fibrosarcoma, Metastatic, Skin | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
Neoplasm NOS | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Carcinoma, Metastatic, Lung | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | X | 4 |
Lymphoma Malignant | X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 2|
DAY ON TEST | 8| 8| 9| 3| 3| 7| 0| 1| 3| 8| 5| 3| 7| 7| 3| 3| 3| 2| 4| 7| 3| 3| 3| 0| 8|
| 8| 7| 8| 7| 8| 0| 7| 4| 7| 0| 5| 8| 3| 6| 8| 9| 9| 7| 2| 0| 9| 9| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3|
MG/M3 | 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 4| 6| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + M + + + + + + + + + + +|
Carcinoma, Metastatic, Liver | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + I + + + + + + + + I + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X X X X X X X |
Hepatocellular Adenoma, Multiple | |
__________________________________________________________________________|
Mesentery | |
Carcinoma, Metastatic, Liver | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Liver | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Adenoma | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + + + I + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | I + + + + + + + + + I + + + + + + + + M + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemangiosarcoma, Metastatic, Bone | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Liver | |
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Penis | + |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 2|
DAY ON TEST | 8| 8| 9| 3| 3| 7| 0| 1| 3| 8| 5| 3| 7| 7| 3| 3| 3| 2| 4| 7| 3| 3| 3| 0| 8|
| 8| 7| 8| 7| 8| 0| 7| 4| 7| 0| 5| 8| 3| 6| 8| 9| 9| 7| 2| 0| 9| 9| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3|
MG/M3 | 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 4| 6| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Bone | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Iliac, Lymphoma Malignant | |
Inguinal, Lymphoma Malignant | |
Pancreatic, Carcinoma, Metastatic, | |
Liver | |
Pancreatic, Lymphoma Malignant | |
Renal, Carcinoma, Metastatic, Liver | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + + + + M + + + M + I I + + I M + + + +|
Carcinoma, Metastatic, Liver | |
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M M + + + + + + + M + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + I + + + + + + + + + + + I + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + M I + M M + M M + M M M M + M M + I M M M M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + M + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Adenoma, | |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 2|
DAY ON TEST | 8| 8| 9| 3| 3| 7| 0| 1| 3| 8| 5| 3| 7| 7| 3| 3| 3| 2| 4| 7| 3| 3| 3| 0| 8|
| 8| 7| 8| 7| 8| 0| 7| 4| 7| 0| 5| 8| 3| 6| 8| 9| 9| 7| 2| 0| 9| 9| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3|
MG/M3 | 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 4| 6| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Multiple | X X |
Alveolar/Bronchiolar Carcinoma | X X |
Carcinoma, Metastatic, Liver | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urethra | + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 4| 6| 7| 7| 5| 6| 5| 5| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 8| 3| 5| 3| 3| 3| 0| 3| 4| 3| 5| 5| 1| 3| 3| 9| 1| 9| 6| 3| 1| 3|
| 7| 7| 7| 5| 9| 3| 8| 9| 9| 8| 9| 0| 4| 2| 2| 4| 9| 8| 7| 4| 7| 8| 7| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
MG/M3 | 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 8| 9| 0| 1| 3| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + M + + + + + + + + + + M + M M + + +|
Carcinoma, Metastatic, Liver | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X X X X X |
Hepatocellular Adenoma | X X X X X X |
Hepatocellular Adenoma, Multiple | X |
__________________________________________________________________________|
Mesentery | + |
Carcinoma, Metastatic, Liver | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Liver | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Adenoma | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + I + + M + + + + + + I|
__________________________________________________________________________|
Pituitary Gland | + + + + M M + + + + + + M + + + + + + + + M + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemangiosarcoma, Metastatic, Bone | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Liver | X |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Penis | + + |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 4| 6| 7| 7| 5| 6| 5| 5| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 8| 3| 5| 3| 3| 3| 0| 3| 4| 3| 5| 5| 1| 3| 3| 9| 1| 9| 6| 3| 1| 3|
| 7| 7| 7| 5| 9| 3| 8| 9| 9| 8| 9| 0| 4| 2| 2| 4| 9| 8| 7| 4| 7| 8| 7| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
MG/M3 | 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 8| 9| 0| 1| 3| 6|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Metastatic, Bone | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Iliac, Lymphoma Malignant | X |
Inguinal, Lymphoma Malignant | X |
Pancreatic, Carcinoma, Metastatic, | |
Liver | X |
Pancreatic, Lymphoma Malignant | X |
Renal, Carcinoma, Metastatic, Liver | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + I + + + + + + M M I + + + + + + + + + +|
Carcinoma, Metastatic, Liver | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + I + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + M + + + + + + + + + + + + + M + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | I + + M + M M M + M M M M + M M M I M + M + M M I|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + M + + M + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 4| 6| 7| 7| 5| 6| 5| 5| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 8| 3| 5| 3| 3| 3| 0| 3| 4| 3| 5| 5| 1| 3| 3| 9| 1| 9| 6| 3| 1| 3|
| 7| 7| 7| 5| 9| 3| 8| 9| 9| 8| 9| 0| 4| 2| 2| 4| 9| 8| 7| 4| 7| 8| 7| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
MG/M3 | 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 8| 9| 0| 1| 3| 6|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X X X X |
Carcinoma, Metastatic, Liver | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urethra | + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 2| 7| 6| 5| 6| | |
DAY ON TEST | 3| 3| 3| 6| 0| 3| 3| 4| 1| 1| | |
| 7| 7| 7| 5| 9| 0| 9| 2| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0 | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| | L |
MG/M3 | 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 55 |
Carcinoma, Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + M + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + M + M + + I | 54 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + M + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + M + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Carcinoma | | 1 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X X | 10 |
Hepatocellular Adenoma | X | 16 |
Hepatocellular Adenoma, Multiple | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Carcinoma, Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Carcinoma, Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Capsule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + M + + M M | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + | 52 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Hemangiosarcoma, Metastatic, Bone | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 64
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 2| 7| 6| 5| 6| | |
DAY ON TEST | 3| 3| 3| 6| 0| 3| 3| 4| 1| 1| | |
| 7| 7| 7| 5| 9| 0| 9| 2| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0 | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| | L |
MG/M3 | 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Carcinoma, Metastatic, Liver | | 1 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Penis | + | 4 |
__________________________________________________________________________|____________|
Preputial Gland | + + + M + + + + + + | 58 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hemangiosarcoma, Metastatic, Bone | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 23 |
Iliac, Lymphoma Malignant | | 1 |
Inguinal, Lymphoma Malignant | | 1 |
Pancreatic, Carcinoma, Metastatic, | | |
Liver | | 1 |
Pancreatic, Lymphoma Malignant | | 1 |
Renal, Carcinoma, Metastatic, Liver | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + M + + I + + | 46 |
Carcinoma, Metastatic, Liver | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + | 55 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 55 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M + I M M + + + | 18 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | + I + + + + + + + + | 54 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 65
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 2| 7| 6| 5| 6| | |
DAY ON TEST | 3| 3| 3| 6| 0| 3| 3| 4| 1| 1| | |
| 7| 7| 7| 5| 9| 0| 9| 2| 6| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0 | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| | L |
MG/M3 | 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + I + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | | 3 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 2 |
Alveolar/Bronchiolar Carcinoma | X X X | 9 |
Carcinoma, Metastatic, Liver | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Ureter | + | 2 |
__________________________________________________________________________|____________|
Urethra | + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 66
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 3| | |
DAY ON TEST | 9| | |
| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE MALE | 0| | T |
ANIMAL ID | 0| | A |
0.0MG/M3 | 2| | L |
LUNG TOX | 7| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 1 |
__________________________________________________________________________|____________|
Gallbladder | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
__________________________________________________________________________|____________|
Liver | + | 1 |
Hepatocellular Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 1 |
__________________________________________________________________________|____________|
Pharynx | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
__________________________________________________________________________|____________|
Prostate | + | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
__________________________________________________________________________|____________|
Testes | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 67
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 3| | |
DAY ON TEST | 9| | |
| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE MALE | 0| | T |
ANIMAL ID | 0| | A |
0.0MG/M3 | 2| | L |
LUNG TOX | 7| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M | |
__________________________________________________________________________|____________|
Spleen | + | 1 |
__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | M | |
__________________________________________________________________________|____________|
Lung | + | 1 |
__________________________________________________________________________|____________|
Nose | + | 1 |
__________________________________________________________________________|____________|
Trachea | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 68
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 6| 7| 5| 5|
DAY ON TEST | 1| 1| 3| 3| 9| 6| 4| 4| 4| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 2| 8| 9| 2| 1| 1|
| 6| 7| 7| 7| 4| 2| 4| 0| 9| 7| 7| 1| 8| 8| 9| 8| 8| 1| 8| 1| 7| 4| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Mesentery | + + |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + I + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Adenoma | |
Extra Adrenal Tissue, Histiocytic | |
Sarcoma | X |
Extra Adrenal Tissue, Lymphoma | |
Malignant | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + M M M + + + M + + M M M + + + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + M + M +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 6| 7| 5| 5|
DAY ON TEST | 1| 1| 3| 3| 9| 6| 4| 4| 4| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 2| 8| 9| 2| 1| 1|
| 6| 7| 7| 7| 4| 2| 4| 0| 9| 7| 7| 1| 8| 8| 9| 8| 8| 1| 8| 1| 7| 4| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Mediastinum, Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + I + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Iliac, Histiocytic Sarcoma | X |
Iliac, Lymphoma Malignant | X |
Inguinal, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant | X |
Renal, Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M M + + + + I + + + + + + + + M M +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + I + I + + + + + + + + + M|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + M + + + + + M + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M + + M M M I + + + + M + + M + M + + M M M M|
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + I M M + I + A M + + + + + M + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Lymphoma | |
Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 6| 7| 5| 5|
DAY ON TEST | 1| 1| 3| 3| 9| 6| 4| 4| 4| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 2| 8| 9| 2| 1| 1|
| 6| 7| 7| 7| 4| 2| 4| 0| 9| 7| 7| 1| 8| 8| 9| 8| 8| 1| 8| 1| 7| 4| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X X X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Urethra | + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 3| 5| 5| 7| 7| 5| 6| 1| 5| 6| 2| 7| 7| 4| 7| 5| 7| 6| 6| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 2| 6| 6| 3| 3| 6| 1| 1| 5| 7| 8| 3| 3| 0| 3| 6| 3| 4| 6| 3|
| 8| 9| 9| 7| 7| 5| 9| 4| 8| 7| 7| 4| 8| 2| 1| 6| 8| 9| 0| 9| 7| 9| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2|
MG/M3 | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 7| 8| 9| 2| 4| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Large, Rectum | I + + + + + + + + + + + + + + + + + + + + + I + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Mesentery | |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Pancreas | + + I + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Adenoma | X |
Extra Adrenal Tissue, Histiocytic | |
Sarcoma | |
Extra Adrenal Tissue, Lymphoma | |
Malignant | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + M + + I + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + M M + M + + M + + + + + + + I +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + M + + + + + + + M + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 3| 5| 5| 7| 7| 5| 6| 1| 5| 6| 2| 7| 7| 4| 7| 5| 7| 6| 6| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 2| 6| 6| 3| 3| 6| 1| 1| 5| 7| 8| 3| 3| 0| 3| 6| 3| 4| 6| 3|
| 8| 9| 9| 7| 7| 5| 9| 4| 8| 7| 7| 4| 8| 2| 1| 6| 8| 9| 0| 9| 7| 9| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2|
MG/M3 | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 7| 8| 9| 2| 4| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tissue NOS | |
Mediastinum, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + I + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Iliac, Histiocytic Sarcoma | |
Iliac, Lymphoma Malignant | |
Inguinal, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant | |
Renal, Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + M + + I + + + M + + + I + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + M + + M + + M + + + M + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + I + + + + + + + M + + + + + M + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + I + M M + + M I + + M + M M I + M M M I + + M|
Lymphoma Malignant | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Histiocytic Sarcoma | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + M + + + + + + + + + M + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Lymphoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 3| 5| 5| 7| 7| 5| 6| 1| 5| 6| 2| 7| 7| 4| 7| 5| 7| 6| 6| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 2| 6| 6| 3| 3| 6| 1| 1| 5| 7| 8| 3| 3| 0| 3| 6| 3| 4| 6| 3|
| 8| 9| 9| 7| 7| 5| 9| 4| 8| 7| 7| 4| 8| 2| 1| 6| 8| 9| 0| 9| 7| 9| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2|
MG/M3 | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 7| 8| 9| 2| 4| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + I + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X|
Alveolar/Bronchiolar Carcinoma | X X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Urethra | + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 5| 5| 6| 5| 7| 5| 7| | |
DAY ON TEST | 9| 1| 3| 8| 4| 6| 5| 3| 9| 3| | |
| 9| 4| 8| 4| 9| 3| 2| 9| 4| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.25 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
MG/M3 | 3| 4| 5| 6| 8| 0| 2| 4| 6| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + M + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + M | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hepatocellular Carcinoma | X | 8 |
Hepatocellular Carcinoma, Multiple | X X | 3 |
Hepatocellular Adenoma | X | 6 |
Hepatocellular Adenoma, Multiple | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + I + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + M | 59 |
Capsule, Adenoma | | 1 |
Extra Adrenal Tissue, Histiocytic | | |
Sarcoma | | 1 |
Extra Adrenal Tissue, Lymphoma | | |
Malignant | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + M | 57 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + M + + M + | 41 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 75
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 5| 5| 6| 5| 7| 5| 7| | |
DAY ON TEST | 9| 1| 3| 8| 4| 6| 5| 3| 9| 3| | |
| 9| 4| 8| 4| 9| 3| 2| 9| 4| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.25 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
MG/M3 | 3| 4| 5| 6| 8| 0| 2| 4| 6| 8| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + | 53 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Mediastinum, Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Penis | + | 7 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 21 |
Iliac, Histiocytic Sarcoma | | 1 |
Iliac, Lymphoma Malignant | | 1 |
Inguinal, Lymphoma Malignant | | 1 |
Pancreatic, Lymphoma Malignant | | 1 |
Renal, Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + I + I + + + + | 48 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M M + + + + | 49 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + I + + + + | 53 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + I M M M I M M + | 24 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Thymus | + M M + + + + + + + | 48 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 76
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 5| 5| 6| 5| 7| 5| 7| | |
DAY ON TEST | 9| 1| 3| 8| 4| 6| 5| 3| 9| 3| | |
| 9| 4| 8| 4| 9| 3| 2| 9| 4| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.25 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
MG/M3 | 3| 4| 5| 6| 8| 0| 2| 4| 6| 8| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Subcutaneous Tissue, Lymphoma | | |
Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + I + + + + | 58 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | X | 4 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | X X X | 10 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 3 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Urethra | + + + | 12 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 77
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 5| 5| 6| 5| 7| 5| 7| | |
DAY ON TEST | 9| 1| 3| 8| 4| 6| 5| 3| 9| 3| | |
| 9| 4| 8| 4| 9| 3| 2| 9| 4| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.25 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
MG/M3 | 3| 4| 5| 6| 8| 0| 2| 4| 6| 8| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 78
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 1| | |
DAY ON TEST | 2| | |
| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE MALE | 0| | T |
ANIMAL ID | 2| | A |
.25MG/M3 | 1| | L |
LUNG TOX | 3| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + | 1 |
__________________________________________________________________________|____________|
Gallbladder | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + | 1 |
__________________________________________________________________________|____________|
Liver | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | I | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | M | |
__________________________________________________________________________|____________|
Pituitary Gland | + | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + | 1 |
__________________________________________________________________________|____________|
Prostate | + | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + | 1 |
__________________________________________________________________________|____________|
Testes | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 79
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 1| | |
DAY ON TEST | 2| | |
| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| | O |
B6C3F1 MICE MALE | 0| | T |
ANIMAL ID | 2| | A |
.25MG/M3 | 1| | L |
LUNG TOX | 3| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M | |
__________________________________________________________________________|____________|
Spleen | + | 1 |
__________________________________________________________________________|____________|
Thymus | + | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + | 1 |
__________________________________________________________________________|____________|
Lung | + | 1 |
__________________________________________________________________________|____________|
Nose | + | 1 |
__________________________________________________________________________|____________|
Trachea | + | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + | 1 |
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 80
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 5| 6| 6| 4| 7| 7| 5| 7| 5| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 1| 4| 5| 9| 2| 1| 0| 3| 9| 3| 6| 3| 3| 3| 3| 4| 1| 3| 9| 3| 3| 6| 3|
| 7| 9| 0| 2| 3| 6| 1| 9| 5| 9| 4| 7| 4| 7| 8| 9| 9| 0| 3| 7| 1| 8| 8| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + A + + + + + + + + + + + I + I + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Rectum | I + M + + + + A + + + + + + + + I + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + M + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + M + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + M + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | M + M + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X X X X X |
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | X X X X X |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + A + + + + + + + + + + + + + + + + +|
Capsule, Adenoma | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + A + + + I + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + M + + + + A M + + + + + + + + + + I + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + + + + + + + I + + + I + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Thyroid Gland | + + I + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Penis | + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 5| 6| 6| 4| 7| 7| 5| 7| 5| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 1| 4| 5| 9| 2| 1| 0| 3| 9| 3| 6| 3| 3| 3| 3| 4| 1| 3| 9| 3| 3| 6| 3|
| 7| 9| 0| 2| 3| 6| 1| 9| 5| 9| 4| 7| 4| 7| 8| 9| 9| 0| 3| 7| 1| 8| 8| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Inguinal, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M I M M + A + + I + + + + + + + + + + + + I +|
Histiocytic Sarcoma | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + M + + + M + + + + + + + + + + M + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M M + + + A + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M + M + I A M M M M I + M M I M + M + + + + M|
__________________________________________________________________________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Thymus | + + + + + + + A + + + + + + + + + M + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + A + + + + + + I + + + + + + + M + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Alveolar/Bronchiolar Carcinoma | X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
__________________________________________________________________________|
Nose | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 5| 6| 6| 4| 7| 7| 5| 7| 5| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 1| 4| 5| 9| 2| 1| 0| 3| 9| 3| 6| 3| 3| 3| 3| 4| 1| 3| 9| 3| 3| 6| 3|
| 7| 9| 0| 2| 3| 6| 1| 9| 5| 9| 4| 7| 4| 7| 8| 9| 9| 0| 3| 7| 1| 8| 8| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urethra | + + + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 5| 6| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 6| 3| 6| 7| 6| 6| 2| 7| 2|
DAY ON TEST | 5| 2| 3| 7| 1| 8| 3| 1| 1| 3| 3| 3| 3| 8| 3| 3| 4| 3| 4| 3| 3| 2| 8| 3| 4|
| 2| 8| 7| 8| 4| 5| 9| 3| 1| 9| 8| 8| 8| 1| 7| 8| 8| 7| 2| 9| 9| 7| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MG/M3 | 2| 3| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + M + + M + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + I + + + + + I + + + I + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + I|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Adenoma | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + M|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M I + M + + + + + M + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Penis | + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 5| 6| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 6| 3| 6| 7| 6| 6| 2| 7| 2|
DAY ON TEST | 5| 2| 3| 7| 1| 8| 3| 1| 1| 3| 3| 3| 3| 8| 3| 3| 4| 3| 4| 3| 3| 2| 8| 3| 4|
| 2| 8| 7| 8| 4| 5| 9| 3| 1| 9| 8| 8| 8| 1| 7| 8| 8| 7| 2| 9| 9| 7| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MG/M3 | 2| 3| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Inguinal, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M I + + + + + + + + + + + + M + I + M|
Histiocytic Sarcoma | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + A + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M I M M M M M + I M M M M + M + M M M M + M M + M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Thymus | M + M + + + + + + M + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 5| 7| 7| 5| 6| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 6| 3| 6| 7| 6| 6| 2| 7| 2|
DAY ON TEST | 5| 2| 3| 7| 1| 8| 3| 1| 1| 3| 3| 3| 3| 8| 3| 3| 4| 3| 4| 3| 3| 2| 8| 3| 4|
| 2| 8| 7| 8| 4| 5| 9| 3| 1| 9| 8| 8| 8| 1| 7| 8| 8| 7| 2| 9| 9| 7| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MG/M3 | 2| 3| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urethra | + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 5| 6| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 7| 8| 3| 2| 1| 0| 9| 1| | |
| 9| 8| 2| 2| 8| 9| 7| 2| 9| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
MG/M3 | 6| 7| 8| 9| 1| 3| 4| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + I M + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hemangiosarcoma | X | 2 |
Hepatocellular Carcinoma | X X | 12 |
Hepatocellular Carcinoma, Multiple | | 3 |
Hepatocellular Adenoma | X X X X X X X | 17 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Tooth | | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Capsule, Adenoma | X | 3 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 55 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + M + + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + | 56 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 87
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 5| 6| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 7| 8| 3| 2| 1| 0| 9| 1| | |
| 9| 8| 2| 2| 8| 9| 7| 2| 9| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
MG/M3 | 6| 7| 8| 9| 1| 3| 4| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 2 |
__________________________________________________________________________|____________|
Penis | + I + | 9 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 20 |
Inguinal, Lymphoma Malignant | | 1 |
Pancreatic, Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M M + + + M + M | 44 |
Histiocytic Sarcoma | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + + + | 55 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + + + M M M | 20 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | + M + M + + + + + + | 51 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + I + + + + + + | 56 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 88
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 5| 6| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 7| 8| 3| 2| 1| 0| 9| 1| | |
| 9| 8| 2| 2| 8| 9| 7| 2| 9| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
MG/M3 | 6| 7| 8| 9| 1| 3| 4| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Carcinoma | | 3 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 3 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urethra | + + + + | 15 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 89
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 3| 4| | |
DAY ON TEST | 8| 5| | |
| 4| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| | T |
ANIMAL ID | 3| 3| | A |
0.5MG/M3 | 5| 9| | L |
LUNG TOX | 1| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Gallbladder | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 2 |
__________________________________________________________________________|____________|
Liver | + + | 2 |
Hepatocellular Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 2 |
__________________________________________________________________________|____________|
Prostate | + + | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________|____________|
Testes | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 90
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 3| 4| | |
DAY ON TEST | 8| 5| | |
| 4| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| | T |
ANIMAL ID | 3| 3| | A |
0.5MG/M3 | 5| 9| | L |
LUNG TOX | 1| 9| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M | |
__________________________________________________________________________|____________|
Spleen | + + | 2 |
__________________________________________________________________________|____________|
Thymus | + + | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 2 |
__________________________________________________________________________|____________|
Skin | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + | 2 |
__________________________________________________________________________|____________|
Lung | + + | 2 |
__________________________________________________________________________|____________|
Nose | + + | 2 |
__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 91
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 6| 5| 7| 6| 7| 7| 1| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 7| 6| 5| 7| 6| 6|
DAY ON TEST | 0| 9| 3| 4| 3| 0| 6| 3| 7| 3| 3| 3| 3| 7| 6| 3| 3| 3| 6| 3| 7| 7| 3| 3| 7|
| 1| 7| 7| 0| 7| 9| 9| 8| 6| 7| 8| 8| 7| 2| 1| 8| 7| 7| 8| 7| 9| 0| 8| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
MG/M3 | 1| 3| 4| 5| 8| 0| 2| 4| 5| 6| 7| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + M + + M + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + + + A I + + + + + + I A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + M + + + + + + + + A + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + M + + + + + A + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Carcinoma, Multiple | X|
Hepatocellular Adenoma | X X X X X X|
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + A + + + + + + + + + +|
Capsule, Adenoma | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M M M M + + + M M M + I + + + I + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 6| 5| 7| 6| 7| 7| 1| 7| 6| 7| 7| 7| 7| 5| 5| 7| 7| 7| 5| 7| 6| 5| 7| 6| 6|
DAY ON TEST | 0| 9| 3| 4| 3| 0| 6| 3| 7| 3| 3| 3| 3| 7| 6| 3| 3| 3| 6| 3| 7| 7| 3| 3| 7|
| 1| 7| 7| 0| 7| 9| 9| 8| 6| 7| 8| 8| 7| 2| 1| 8| 7| 7| 8| 7| 9| 0| 8| 8| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
MG/M3 | 1| 3| 4| 5| 8| 0| 2| 4| 5| 6| 7| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + M + + M M + + + + + I M + + M + M + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + A + M + + + M + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M + I + M I + + M + + + M + + M M + I M + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Thymus | + + + M + + + + + + M + + + A I M + M + M + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X X X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urethra | + + + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 5| 5| 6| 6| 6| 5| 7| 4| 5| 6| 7| 6|
DAY ON TEST | 3| 3| 9| 2| 3| 4| 3| 0| 1| 2| 3| 3| 0| 0| 9| 5| 7| 7| 2| 3| 0| 9| 9| 3| 4|
| 7| 7| 9| 1| 8| 1| 8| 3| 0| 0| 7| 9| 4| 3| 4| 7| 5| 5| 9| 9| 4| 7| 9| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MG/M3 | 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | I + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + A + M + + A + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + I + + I +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pharynx | + |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Adenoma | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + M + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M M + + + + + + + I + + M + M + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + M + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 94
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 5| 5| 6| 6| 6| 5| 7| 4| 5| 6| 7| 6|
DAY ON TEST | 3| 3| 9| 2| 3| 4| 3| 0| 1| 2| 3| 3| 0| 0| 9| 5| 7| 7| 2| 3| 0| 9| 9| 3| 4|
| 7| 7| 9| 1| 8| 1| 8| 3| 0| 0| 7| 9| 4| 3| 4| 7| 5| 5| 9| 9| 4| 7| 9| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
MG/M3 | 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + I + M + + + + + + + + + + M + M + + + + + + + M|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + M + + + + + + + + + + M I|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + I M M + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M + M I M + I + + M M M M + M M M + M + +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thymus | + + M + + + + + + + + M + + + M + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X |
Alveolar/Bronchiolar Carcinoma | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urethra | + + + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 95
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 5| 3| 7| 7| 3| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| | |
| 9| 3| 0| 9| 9| 3| 4| 8| 9| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.0 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/M3 | 7| 9| 0| 1| 3| 4| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + M + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | I + M + I + + I + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + M + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + M + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + | 55 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Hepatocellular Carcinoma | X X | 8 |
Hepatocellular Carcinoma, Multiple | X | 2 |
Hepatocellular Adenoma | X X | 10 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + I + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Pharynx | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Tooth | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Capsule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + M + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + | 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Penis | + | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 96
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 5| 3| 7| 7| 3| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| | |
| 9| 3| 0| 9| 9| 3| 4| 8| 9| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.0 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/M3 | 7| 9| 0| 1| 3| 4| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Preputial Gland | + + + M + + + + + + | 59 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 25 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + + + I | 53 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + M + + M + + M | 44 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M + I + M M M M | 23 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Thymus | + + M M M M + + + I | 44 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | X X | 4 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 1 |
Alveolar/Bronchiolar Carcinoma | | 3 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X X | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 97
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 7| 5| 6| 7| 7| 5| 3| 7| 7| 3| | |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 9| 3| 3| 2| | |
| 9| 3| 0| 9| 9| 3| 4| 8| 9| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
1.0 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/M3 | 7| 9| 0| 1| 3| 4| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Ureter | | 1 |
__________________________________________________________________________|____________|
Urethra | + + | 16 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 98
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 4| 4| | |
DAY ON TEST | 5| 4| | |
| 8| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| | T |
ANIMAL ID | 5| 5| | A |
1.0MG/M3 | 1| 3| | L |
LUNG TOX | 1| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Gallbladder | + A | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A | 1 |
__________________________________________________________________________|____________|
Liver | + A | 1 |
__________________________________________________________________________|____________|
Pancreas | + A | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + A | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + A | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + A | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + A | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + A | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + A | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + | 2 |
__________________________________________________________________________|____________|
Pituitary Gland | + A | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + A | 1 |
__________________________________________________________________________|____________|
Prostate | + + | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________|____________|
Testes | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + A | 1 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + A | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 99
NTP Experiment-Test: 05122-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 17:53:06
__________________________________________________________________________________________________________________________________
| 4| 4| | |
DAY ON TEST | 5| 4| | |
| 8| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| | T |
ANIMAL ID | 5| 5| | A |
1.0MG/M3 | 1| 3| | L |
LUNG TOX | 1| 8| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + A | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + A | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M | |
__________________________________________________________________________|____________|
Spleen | + A | 1 |
__________________________________________________________________________|____________|
Thymus | + A | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + A | 1 |
__________________________________________________________________________|____________|
Skin | + A | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + | 2 |
__________________________________________________________________________|____________|
Lung | + A | 1 |
__________________________________________________________________________|____________|
Nose | + A | 1 |
__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
__________________________________________________________________________|____________|
Ureter | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + A | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 100
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---------- END OF REPORT ----------
------------------------------------------------------------