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TDMS Study 05122-06 Pathology Tables

NTP Experiment-Test: 05122-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:26:20

                                                          66 Week SSAC




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  010101970

       Lock Date:  04/19/94

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     08/30/89 - 08/31/89

       Treatment Groups:       Include All


































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 05122-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:26:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    0.0MG/M3                               | 8| 8| 9| 0| 1| 4| 4| 4| 5| 5|                                            |     L      |
    LUNG TOX                               | 3| 4| 9| 7| 0| 7| 8| 9| 5| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    I  +        +  I     +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +        +  +     +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +        +  +     +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  M        +  +     +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +        +  +     +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +        +  +     +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    M  +        +  M     I                                                |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    M  M        +  M     +                                                |   2        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   2                                                               
NTP Experiment-Test: 05122-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:26:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    0.0MG/M3                               | 8| 8| 9| 0| 1| 4| 4| 4| 5| 5|                                            |     L      |
    LUNG TOX                               | 3| 4| 9| 7| 0| 7| 8| 9| 5| 8|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +        +  +     +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +        +  +     +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +        +  +     +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +        +  +     +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +  +        +  I     +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +        +  +     +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +        +  +     +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +        +  +     +                                                |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +        +  +     +                                                |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   3                                                               
NTP Experiment-Test: 05122-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:26:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|                                            |     A      |
    .25MG/M3                               | 4| 5| 6| 6| 7| 8| 9| 0| 1| 1|                                            |     L      |
    LUNG TOX                               | 2| 5| 5| 9| 2| 4| 5| 8| 0| 3|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +        I  +     +  +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +        +  +     +  +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +        +  +     +  +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +        M  +     M  +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +        +  +     +  +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +        +  +     +  +                                             |   5        |
      Luteoma                              |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +        +  +     +  +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       M        +  +     M  +                                             |   3        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   4                                                               
NTP Experiment-Test: 05122-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:26:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|                                            |     A      |
    .25MG/M3                               | 4| 5| 6| 6| 7| 8| 9| 0| 1| 1|                                            |     L      |
    LUNG TOX                               | 2| 5| 5| 9| 2| 4| 5| 8| 0| 3|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |       +        I  M     I  M                                             |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       M        +  +     M  +                                             |   3        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +        +  +     +  +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +        +  +     +  +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +        +  +     +  +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |       +        +  I     +  +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +        +  +     +  +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +        +  +     +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +        +  +     +  +                                             |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |       +        +  +     +  +                                             |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   5                                                               
NTP Experiment-Test: 05122-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:26:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.5MG/M3                               | 2| 3| 3| 4| 5| 6| 6| 6| 6| 7|                                            |     L      |
    LUNG TOX                               | 0| 4| 6| 4| 1| 1| 2| 4| 6| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +           M        +  +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +           +        +  +                                             |   5        |
      Hepatocellular Adenoma               | X  X                                                                     |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +           +        +  +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +           +        +  +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +           +        +  +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +           +        +  +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +           +        +  +                                             |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   6                                                               
NTP Experiment-Test: 05122-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:26:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    0.5MG/M3                               | 2| 3| 3| 4| 5| 6| 6| 6| 6| 7|                                            |     L      |
    LUNG TOX                               | 0| 4| 6| 4| 1| 1| 2| 4| 6| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M           M        M  M                                             |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +           +        +  +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +           +        +  +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +           +        +  +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +           +        +  +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  I           +        I  I                                             |   2        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +           +        +  +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +           +        +  +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +           +        +  +                                             |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +           +        +  +                                             |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   7                                                               
NTP Experiment-Test: 05122-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:26:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|                                            |     A      |
    1.0MG/M3                               | 6| 7| 1| 1| 1| 2| 2| 3| 3| 4|                                            |     L      |
    LUNG TOX                               | 1| 9| 0| 1| 9| 4| 8| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +  I     +  +     +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   |          +  +     +  +     +                                             |   5        |
      Hepatocellular Adenoma               |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +  +     +  +     +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +     +  +     +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +  +        +     I                                             |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +  +     +  I     +                                             |   4        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +  +     +  +     +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |          +  +     +  +     +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |          +  +     +  +     I                                             |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +  +     +  +     M                                             |   4        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   8                                                               
NTP Experiment-Test: 05122-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:26:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|                                            |     A      |
    1.0MG/M3                               | 6| 7| 1| 1| 1| 2| 2| 3| 3| 4|                                            |     L      |
    LUNG TOX                               | 1| 9| 0| 1| 9| 4| 8| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |          M  M     +  +     M                                             |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +  +     +  +     +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +  +     +  +     +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +  +     +  +     +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +  +     +  +     +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |          +  +     +  +     I                                             |   4        |
                                            __________________________________________________________________________|____________|
   Lung                                    |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +  +     +  +     +                                             |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +                                                   |   1        |
      Adenoma                              |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +  +     +  +     +                                             |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +  +     +  +     +                                             |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |          +  +     +  +     +                                             |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   9                                                               
NTP Experiment-Test: 05122-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:26:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4|                                               |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5|                                               |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8|                                               |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     A      |
    0.0MG/M3                               | 0| 2| 3| 5| 5| 5| 6| 7| 8|                                               |     L      |
    LUNG TOX                               | 6| 3| 3| 0| 2| 3| 4| 7| 0|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +  +  +  +     M                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +  +  +  I     +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   |       +  +  +  +     +                                                   |   5        |
      Hepatocellular Adenoma               |          X           X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +  +  +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +  +  +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +  +  +  I     M                                                   |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +  +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Prostate                                |       +  +  I  +     +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Testes                                  |       +  +  +  +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |       +  +  +  M     +                                                   |   4        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  10                                                               
NTP Experiment-Test: 05122-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:26:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4|                                               |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5|                                               |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8|                                               |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |     A      |
    0.0MG/M3                               | 0| 2| 3| 5| 5| 5| 6| 7| 8|                                               |     L      |
    LUNG TOX                               | 6| 3| 3| 0| 2| 3| 4| 7| 0|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +  +  M  +     +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +  M  +  +     +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |       M  M  M  I     M                                                   |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +  +  +  +     I                                                   |   4        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       M  +  M  M     M                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +  +  +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +  +  +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +  +  +  +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +  +  +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +  +  +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +  +  +     +                                                   |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |       +  +  +  +     +                                                   |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  11                                                               
NTP Experiment-Test: 05122-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:26:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    .25MG/M3                               | 8| 0| 0| 1| 2| 3| 3| 3| 3| 4|                                            |     L      |
    LUNG TOX                               | 7| 3| 6| 0| 9| 1| 3| 7| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +     I  +  +        +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +     +  +  M        +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +     +  +  M        +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +     +  +  M        +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +     +  +  +        +                                                |   5        |
      Hepatocellular Adenoma               |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +     +  +  +        I                                                |   4        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +     +  +  +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +     +  +  +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +     +  +  +        +                                                |   5        |
      Capsule, Adenoma                     |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +     +  +  +        I                                                |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    I     +  +  I        +                                                |   3        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +     +  +  +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +     +  +  +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +     +  +  +        +                                                |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  12                                                               
NTP Experiment-Test: 05122-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:26:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    .25MG/M3                               | 8| 0| 0| 1| 2| 3| 3| 3| 3| 4|                                            |     L      |
    LUNG TOX                               | 7| 3| 6| 0| 9| 1| 3| 7| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +     +  +  M        +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +     +  +  +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +     M  +  M        M                                                |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +     +  +  +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +     +  +  +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +     +  +  +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +     +  +  +        +                                                |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +  +  +        +                                                |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +     +  +  +        +                                                |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +     +  +  +        +                                                |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  13                                                               
NTP Experiment-Test: 05122-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:26:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4|                                                  |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5|                                                  |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3|                                                  |     A      |
    0.5MG/M3                               | 3| 3| 3| 5| 6| 7| 9| 9|                                                  |     L      |
    LUNG TOX                               | 2| 5| 6| 4| 8| 1| 0| 2|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +  +     +     I                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +     +     +                                                   |   5        |
      Hepatocellular Adenoma               |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +     +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +     +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +  +     +     I                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +     +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +  +     M     +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +  +     +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +                                                               |   2        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  14                                                               
NTP Experiment-Test: 05122-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:26:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4|                                                  |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5|                                                  |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3|                                                  |     A      |
    0.5MG/M3                               | 3| 3| 3| 5| 6| 7| 9| 9|                                                  |     L      |
    LUNG TOX                               | 2| 5| 6| 4| 8| 1| 0| 2|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M     +  M     +     +                                                   |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M     M  M     M     M                                                   |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +  +     +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M     M  M     M     M                                                   |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +     +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +  +     +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +     +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +  +     I     +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +     +     +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +  +     +     +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +     +     +                                                   |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +  +     +     +                                                   |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  15                                                               
NTP Experiment-Test: 05122-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:26:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4|                                                  |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5|                                                  |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5|                                                  |     A      |
    1.0MG/M3                               | 8| 8| 9| 9| 0| 3| 4| 4|                                                  |     L      |
    LUNG TOX                               | 2| 9| 1| 8| 5| 6| 0| 8|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +        +  +  I  +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    M        +  +  +  +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +        +  +  +  +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +        +  +  +  +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    M        +  +  +  +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +        +  I  +  +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +        +  +  +  +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +        +  +  +  +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +  +                                                      |   2        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +        +  +  +  +                                                   |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  16                                                               
NTP Experiment-Test: 05122-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 03/27/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 16:26:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4|                                                  |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5|                                                  |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8|                                                  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0|                                                  |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5|                                                  |     A      |
    1.0MG/M3                               | 8| 8| 9| 9| 0| 3| 4| 4|                                                  |     L      |
    LUNG TOX                               | 2| 9| 1| 8| 5| 6| 0| 8|                                                  |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +        +  +  M  +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +        +  +  M  +                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    M        M  M  +  I                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +        +  +  +  +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M        M  M  M  M                                                   |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +        +  +  +  +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +        +  +  +  +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +        +  +  +  +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    I        +  +  +  I                                                   |   3        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +        +  +  +  +                                                   |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +        +  +  +  +                                                   |   5        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +        +  +  +  +                                                   |   5        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +        +  +  +  +                                                   |   5        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  17                                                               
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