TDMS Study 05122-06 Pathology Tables
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 010101970
Lock Date: 04/19/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 6| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 9| 9| 3| 3| 3| 0| 1| 3| 3| 1| 0| 3| 2| 3| 3| 3| 3| 2| 9| 2|
| 8| 1| 0| 6| 3| 8| 8| 1| 6| 1| 0| 4| 0| 6| 4| 7| 2| 6| 0| 0| 5| 6| 5| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1|
MG/M3 | 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + I + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Intussusception | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Congestion | |
Fatty Change | 1 |
Hemorrhage | 4 |
Infarct | 4 |
Inflammation | |
Necrosis, Diffuse | 3 |
Necrosis | 3 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Inflammation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Extra Adrenal Tissue, Inflammation | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + I + M + + M + + + + M + + I + + M + M + M|
Bilateral, Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 6| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 9| 9| 3| 3| 3| 0| 1| 3| 3| 1| 0| 3| 2| 3| 3| 3| 3| 2| 9| 2|
| 8| 1| 0| 6| 3| 8| 8| 1| 6| 1| 0| 4| 0| 6| 4| 7| 2| 6| 0| 0| 5| 6| 5| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1|
MG/M3 | 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Hyperplasia | 1 1 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Cystic | 2 1 1 1 1 2 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Thrombosis | X |
Mediastinum, Inflammation | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 1|
Inflammation | |
Pigmentation | 1 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + I + + + + +|
Atrophy | |
Cyst | X X 1 |
Inflammation | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 4 |
Endometrium, Hyperplasia | 2 1 3 3 2 2 2 3 3 2 2 3 3 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Megakaryocyte | 2 |
Hyperplasia, Plasma Cell | |
Myelofibrosis | 2 1 2 1 1 1 1 1 1 1 1 1 1 1 |
Erythroid Cell, Hyperplasia | 3 |
Myeloid Cell, Hyperplasia | 1 |
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Plasma Cell | |
Inguinal, Hyperplasia, Lymphoid | |
Pancreatic, Inflammation | |
Renal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + I + I I + + + + + + + + M + + + + + + + + +|
Congestion | |
Edema | |
Hyperplasia, Lymphoid | 1 1 2 3 3 1 |
Hyperplasia, Macrophage | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 6| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 9| 9| 3| 3| 3| 0| 1| 3| 3| 1| 0| 3| 2| 3| 3| 3| 3| 2| 9| 2|
| 8| 1| 0| 6| 3| 8| 8| 1| 6| 1| 0| 4| 0| 6| 4| 7| 2| 6| 0| 0| 5| 6| 5| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1|
MG/M3 | 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Plasma Cell | 1 |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + M +|
Congestion | |
Cyst | X |
Hyperplasia, Lymphoid | 3 2 1 4 1 3 2 3 |
Hyperplasia, Plasma Cell | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Edema | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Inflammation | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M + M M + + I + M M M M M M M + + I M + + M +|
Hyperplasia, Lymphoid | |
Inflammation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Hematopoietic Cell Proliferation | 2 1 4 1 3 2|
Hyperplasia, Lymphoid | 2 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 3 1 2 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Hindlimb, Hemorrhage | |
Pinna, Inflammation | 4 |
Subcutaneous Tissue, Edema | |
Tail, Inflammation | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | 3 |
Periosteum, Femur, Inflammation | 1 |
Tibia, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | + + |
Inflammation | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 3| 7| 7| 6| 6|
DAY ON TEST | 2| 3| 3| 3| 3| 9| 9| 3| 3| 3| 0| 1| 3| 3| 1| 0| 3| 2| 3| 3| 3| 3| 2| 9| 2|
| 8| 1| 0| 6| 3| 8| 8| 1| 6| 1| 0| 4| 0| 6| 4| 7| 2| 6| 0| 0| 5| 6| 5| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1|
MG/M3 | 1| 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 8| 1| 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Meninges, Inflammation | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Hemorrhage | 2 2 |
Hyperplasia, Macrophage | 1 1 |
Inflammation, Chronic Active | 1 |
Pleura, Inflammation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration | 1 1 1|
Respiratory Epithelium, Degeneration | 1 1 |
Respiratory Epithelium, Inflammation | 2 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | |
Nephropathy | |
Medulla, Cyst | X |
Perirenal Tissue, Inflammation | |
__________________________________________________________________________|
Urinary Bladder | + I + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Inflammation | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 2| 3| 7| 7| 5| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 7| 5| 8| 3| 3| 3| 2| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 0|
| 3| 0| 0| 8| 4| 1| 4| 0| 7| 2| 1| 2| 7| 0| 2| 1| 0| 0| 6| 4| 0| 9| 1| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
MG/M3 | 3| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + I + + + + + + + + + + + + + + +|
Dilatation | 1 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + I + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + M M + + + + + + + + + + +|
Intussusception | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 2 |
Congestion | 4 |
Fatty Change | |
Hemorrhage | |
Infarct | |
Inflammation | 1 |
Necrosis, Diffuse | 3 1 |
Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation | |
__________________________________________________________________________|
Pancreas | M + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Hyperplasia, Focal | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + M + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Extra Adrenal Tissue, Inflammation | |
__________________________________________________________________________|
Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + I + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M M + M I + + M M M + + + + + + + + + + + + +|
Bilateral, Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Angiectasis | 3 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 2| 3| 7| 7| 5| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 7| 5| 8| 3| 3| 3| 2| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 0|
| 3| 0| 0| 8| 4| 1| 4| 0| 7| 2| 1| 2| 7| 0| 2| 1| 0| 0| 6| 4| 0| 9| 1| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
MG/M3 | 3| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Hyperplasia | 1 1 3 |
__________________________________________________________________________|
Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Cystic | 2 1 1 2 1 1 1 1 2 3 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Thrombosis | |
Mediastinum, Inflammation | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + + + + + I + + + + + + I + + +|
Ectasia | 1 2 |
Inflammation | 3 |
Pigmentation | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + I + + + + + + + + + + + + + + + + +|
Atrophy | 2|
Cyst | X X |
Inflammation | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Endometrium, Hyperplasia | 1 1 3 1 2 2 2 3 3 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | |
Hyperplasia, Megakaryocyte | |
Hyperplasia, Plasma Cell | 1 |
Myelofibrosis | 1 1 1 1 1 1 1 1 1 3 1 1 1 2 1 1 |
Erythroid Cell, Hyperplasia | |
Myeloid Cell, Hyperplasia | 2 2 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Iliac, Hyperplasia, Lymphoid | 2 |
Iliac, Hyperplasia, Plasma Cell | |
Inguinal, Hyperplasia, Lymphoid | 2 3 |
Pancreatic, Inflammation | 3 |
Renal, Hyperplasia, Lymphoid | 2 |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + + I M + + + + + + I + + + + +|
Congestion | 4 |
Edema | |
Hyperplasia, Lymphoid | 2 1 1 4 2 3 1 |
Hyperplasia, Macrophage | 1 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 2| 3| 7| 7| 5| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 7| 5| 8| 3| 3| 3| 2| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 0|
| 3| 0| 0| 8| 4| 1| 4| 0| 7| 2| 1| 2| 7| 0| 2| 1| 0| 0| 6| 4| 0| 9| 1| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
MG/M3 | 3| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Plasma Cell | |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + M + + + + + + + + + + + + + + + + I + +|
Congestion | 3 |
Cyst | |
Hyperplasia, Lymphoid | 1 1 2 4 3 3 3 |
Hyperplasia, Plasma Cell | 4 1|
__________________________________________________________________________|
Lymph Node, Mesenteric | + M + + + M + + + + I + M + + + + + + + + + + + +|
Congestion | 4 2 |
Edema | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + M + + + + M M M + + + + + + + M + M I I +|
Hyperplasia, Lymphoid | 2 2 2 |
Inflammation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 2 3 1 |
Hyperplasia, Lymphoid | 2 1 1 2 1 3 1 1|
Necrosis | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + I + + + +|
Atrophy | 2 3 3 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
Hindlimb, Hemorrhage | 2 |
Pinna, Inflammation | |
Subcutaneous Tissue, Edema | |
Tail, Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | |
Periosteum, Femur, Inflammation | |
Tibia, Fracture | X |
__________________________________________________________________________|
Skeletal Muscle | + + |
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 6| 2| 3| 7| 7| 5| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 7| 5| 8| 3| 3| 3| 2| 3| 3| 3| 4| 4| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 0|
| 3| 0| 0| 8| 4| 1| 4| 0| 7| 2| 1| 2| 7| 0| 2| 1| 0| 0| 6| 4| 0| 9| 1| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
MG/M3 | 3| 5| 6| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 4|
Meninges, Inflammation | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | M + + + + + + + + + + + + I + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 |
Hyperplasia, Macrophage | 2 1 2 2 2 |
Inflammation, Chronic Active | |
Pleura, Inflammation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy | 1 1 2|
Olfactory Epithelium, Degeneration | 1 1 1 |
Respiratory Epithelium, Degeneration | 1 1 |
Respiratory Epithelium, Inflammation | 2 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Osseous | 1 |
Nephropathy | 1 2 |
Medulla, Cyst | |
Perirenal Tissue, Inflammation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Inflammation | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 5| 9| 3| 8| 3| 3| | |
| 1| 3| 6| 3| 5| 5| 3| 5| 6| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/M3 | 5| 6| 0| 1| 2| 3| 4| 6| 7| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 59 |
Dilatation | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + I + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | M + + + + + + + + + | 57 |
Intussusception | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 2 2.0|
Congestion | | 1 4.0|
Fatty Change | | 1 1.0|
Hemorrhage | | 1 4.0|
Infarct | 4 | 2 4.0|
Inflammation | | 1 1.0|
Necrosis, Diffuse | 1 | 4 2.0|
Necrosis | | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 7 |
Inflammation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Acinus, Hyperplasia, Focal | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Cyst | | 1 |
Extra Adrenal Tissue, Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Mineralization | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 5| 9| 3| 8| 3| 3| | |
| 1| 3| 6| 3| 5| 5| 3| 5| 6| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/M3 | 5| 6| 0| 1| 2| 3| 4| 6| 7| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + M + M + I | 40 |
Bilateral, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 58 |
Angiectasis | | 1 3.0|
Pars Distalis, Angiectasis | 3 | 3 1.7|
Pars Distalis, Hyperplasia | 2 2 4 1 1 | 12 1.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Follicular Cell, Hyperplasia, Cystic | 3 | 22 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 5 |
Thrombosis | | 1 |
Mediastinum, Inflammation | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 57 |
Ectasia | | 4 1.5|
Inflammation | 1 | 2 2.0|
Pigmentation | | 3 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 58 |
Atrophy | | 1 2.0|
Cyst | X | 6 1.0|
Inflammation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Hemorrhage | | 1 4.0|
Endometrium, Hyperplasia | 3 1 1 2 1 2 | 30 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Megakaryocyte | | 1 2.0|
Hyperplasia, Plasma Cell | | 1 1.0|
Myelofibrosis | 1 1 1 1 1 1 1 1 2 | 39 1.2|
Erythroid Cell, Hyperplasia | | 1 3.0|
Myeloid Cell, Hyperplasia | 1 3 | 6 1.7|
__________________________________________________________________________|____________|
Lymph Node | + | 11 |
Iliac, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 5| 9| 3| 8| 3| 3| | |
| 1| 3| 6| 3| 5| 5| 3| 5| 6| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/M3 | 5| 6| 0| 1| 2| 3| 4| 6| 7| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Iliac, Hyperplasia, Plasma Cell | 4 | 1 4.0|
Inguinal, Hyperplasia, Lymphoid | | 2 2.5|
Pancreatic, Inflammation | | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Hyperplasia, Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + I I + + + | 50 |
Congestion | | 1 4.0|
Edema | 3 | 1 3.0|
Hyperplasia, Lymphoid | 1 1 | 15 1.8|
Hyperplasia, Macrophage | 1 | 2 1.0|
Hyperplasia, Plasma Cell | 2 | 2 1.5|
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 55 |
Congestion | | 1 3.0|
Cyst | | 1 |
Hyperplasia, Lymphoid | | 15 2.4|
Hyperplasia, Plasma Cell | 2 3 | 5 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 56 |
Congestion | 2 | 4 2.3|
Edema | 3 | 1 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | 4 | 1 4.0|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + M + M M M + I | 30 |
Hyperplasia, Lymphoid | | 3 2.0|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Congestion | 2 | 3 2.0|
Hematopoietic Cell Proliferation | 2 3 | 11 2.2|
Hyperplasia, Lymphoid | 2 | 10 1.6|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + | 57 |
Atrophy | 1 2 4 | 14 2.1|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Ectasia | | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 5| 9| 3| 8| 3| 3| | |
| 1| 3| 6| 3| 5| 5| 3| 5| 6| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/M3 | 5| 6| 0| 1| 2| 3| 4| 6| 7| 0| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation | | 1 3.0|
Hindlimb, Hemorrhage | | 1 2.0|
Pinna, Inflammation | | 1 4.0|
Subcutaneous Tissue, Edema | 2 | 1 2.0|
Tail, Inflammation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Femur, Hyperostosis | | 1 3.0|
Periosteum, Femur, Inflammation | | 1 1.0|
Tibia, Fracture | | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 4 |
Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 2 3.0|
Meninges, Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 58 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 1.0|
Hemorrhage | 1 | 4 1.5|
Hyperplasia, Macrophage | | 7 1.6|
Inflammation, Chronic Active | | 1 1.0|
Pleura, Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Olfactory Epithelium, Atrophy | | 3 1.3|
Olfactory Epithelium, Degeneration | 1 1 1 1 1 1 | 12 1.0|
Respiratory Epithelium, Degeneration | 1 1 1 1 1 1 1 | 11 1.0|
Respiratory Epithelium, Inflammation | 1 | 5 1.8|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 5| 9| 3| 8| 3| 3| | |
| 1| 3| 6| 3| 5| 5| 3| 5| 6| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/M3 | 5| 6| 0| 1| 2| 3| 4| 6| 7| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Metaplasia, Osseous | | 1 1.0|
Nephropathy | 2 | 3 1.7|
Medulla, Cyst | | 1 |
Perirenal Tissue, Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Angiectasis | | 1 2.0|
Inflammation | 4 | 1 4.0|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 2| 4| 2| 4| 2| 0| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 2| | |
DAY ON TEST | 5| 5| 5| 0| 5| 0| 5| 0| 3| 0| 0| 0| 0| 0| 5| 5| 5| 5| 5| 0| | |
| 9| 9| 9| 7| 9| 7| 9| 7| 5| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 8| 8| 9| 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 4| 4| 4| 4| 5| 5| 5| | L |
LUNG TOX | 3| 4| 9| 6| 7| 9| 0| 4| 7| 9| 2| 5| 6| 4| 7| 8| 9| 5| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 6 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | I + + + I + | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 6 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 6 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 6 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 6 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 6 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 6 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 6 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 6 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 6 |
Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + | 6 |
Inflammation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + | 6 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + | 7 |
Endometrium, Hyperplasia | 2 1 3 2 1 | 5 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 6 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + M + + + M I + | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 2| 4| 2| 4| 2| 0| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 2| | |
DAY ON TEST | 5| 5| 5| 0| 5| 0| 5| 0| 3| 0| 0| 0| 0| 0| 5| 5| 5| 5| 5| 0| | |
| 9| 9| 9| 7| 9| 7| 9| 7| 5| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 8| 8| 9| 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 4| 4| 4| 4| 5| 5| 5| | L |
LUNG TOX | 3| 4| 9| 6| 7| 9| 0| 4| 7| 9| 2| 5| 6| 4| 7| 8| 9| 5| 8| 9| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + | 9 |
Hyperplasia, Lymphoid | 2 2 2 3 1 2 | 6 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M M + M + M | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 6 |
__________________________________________________________________________|____________|
Thymus | + + + + + + | 6 |
Atrophy | 2 | 1 2.0|
Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 6 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 6 |
Inflammation | 3 | 1 3.0|
Ulcer | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + M + I + | 4 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + | 11 |
Interstitium, Infiltration Cellular | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + | 11 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Acute | 1 1 1 1 | 4 1.0|
Olfactory Epithelium, Degeneration | 1 | 1 1.0|
Olfactory Epithelium, Respiratory | | |
Epithelium, Degeneration | 2 | 1 2.0|
Respiratory Epithelium, Degeneration | 1 | 1 1.0|
Vomeronasal Organ, Infiltration | | |
Cellular, Polymorphonuclear | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 2| 4| 2| 4| 2| 0| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 2| | |
DAY ON TEST | 5| 5| 5| 0| 5| 0| 5| 0| 3| 0| 0| 0| 0| 0| 5| 5| 5| 5| 5| 0| | |
| 9| 9| 9| 7| 9| 7| 9| 7| 5| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 8| 8| 9| 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 4| 4| 4| 4| 5| 5| 5| | L |
LUNG TOX | 3| 4| 9| 6| 7| 9| 0| 4| 7| 9| 2| 5| 6| 4| 7| 8| 9| 5| 8| 9| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 0| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 6| 3| 3| 7| 3| 1| 3| 3| 6| 4| 3| 3| 3|
| 5| 7| 1| 3| 1| 0| 8| 3| 0| 2| 1| 4| 1| 3| 6| 9| 1| 4| 0| 1| 6| 9| 3| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/M3 | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + A + + + + + + + + + + + + + A + + + +|
Concretion | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Autolysis | |
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + + +|
Autolysis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + A + + + +|
Autolysis | 2 |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | |
Inflammation | |
Necrosis, Diffuse | 3 3 |
Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +|
Amyloid Deposition | 2|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hyperplasia, Squamous | 1 |
Inflammation | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Tooth | + + |
Peridontal Tissue, Inflammation | 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + A I + + +|
Capsule, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + A I + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + I + + + + + + + + + + A + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 0| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 6| 3| 3| 7| 3| 1| 3| 3| 6| 4| 3| 3| 3|
| 5| 7| 1| 3| 1| 0| 8| 3| 0| 2| 1| 4| 1| 3| 6| 9| 1| 4| 0| 1| 6| 9| 3| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/M3 | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | M I + + + + + + + + M + + + + + + + + + M M M + +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + I + + + + + + + + + + + + + A + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Hyperplasia | 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Cystic | 1 1 1 3 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + +|
Abdominal, Inflammation | 2|
Mediastinum, Infiltration Cellular, | |
Lymphocyte | |
Mediastinum, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + M + + + + + + + + + + + + I + + + + + + +|
Ectasia | 1 1 |
Hyperplasia, Squamous | |
Inflammation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + A + + M +|
Cyst | X |
Hemorrhage | 4 |
Bilateral, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation | |
Thrombosis | |
Endometrium, Hyperplasia | 1 3 3 3 3 3 2 2 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + A + + + +|
Myelofibrosis | 1 2 1 4 1 2 2 1 1 1 2 1 1 2 2 2 2 1|
Myeloid Cell, Hyperplasia | 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Hyperplasia, Lymphoid | 3 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
Renal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + I + + + + + + + + + M + + A + + + +|
Amyloid Deposition | 2|
Congestion | 3 |
Hyperplasia, Lymphoid | 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + I + + + + A + + + +|
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 0| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 6| 3| 3| 7| 3| 1| 3| 3| 6| 4| 3| 3| 3|
| 5| 7| 1| 3| 1| 0| 8| 3| 0| 2| 1| 4| 1| 3| 6| 9| 1| 4| 0| 1| 6| 9| 3| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/M3 | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Plasma Cell | 3 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + A + + + + + + I + + + + + + A + + + M|
Congestion | 2 |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + M + + + I + M M M + M + M M + M M M M +|
Hyperplasia, Plasma Cell | |
Inflammation | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + A + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 2 2 1 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + I + + + I + + + A + + + +|
Atrophy | 3 2 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + A I + + +|
Ectasia | 2 1 |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Dermis, Fibrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | 1 |
__________________________________________________________________________|
Skeletal Muscle | |
Inflammation | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + A + + + +|
Compression | 3 1 |
Pons, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + I + + +|
Inflammation | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Emphysema | 2 |
Hemorrhage | |
Hyperplasia, Macrophage | 1 3 1 1 1 1 2 1 4 1|
Inflammation, Chronic Active | 1 2 1 1 1 2 1|
Inflammation | |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 0| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 2| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 1| 6| 3| 3| 7| 3| 1| 3| 3| 6| 4| 3| 3| 3|
| 5| 7| 1| 3| 1| 0| 8| 3| 0| 2| 1| 4| 1| 3| 6| 9| 1| 4| 0| 1| 6| 9| 3| 1| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/M3 | 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 0| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 |
Interstitium, Infiltration Cellular | 3 2 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + A + + + +|
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Degeneration | 1 1 1 1 |
Olfactory Epithelium, Inflammation | 1 |
Respiratory Epithelium, Degeneration | 1 1 1 1 1 1 1 |
Respiratory Epithelium, Inflammation | 2 3 1 1 2|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Hemorrhage | 2 |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Mineralization | 1|
Nephropathy | |
Glomerulus, Inflammation | 3 |
Renal Tubule, Necrosis, Acute | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Calculus Micro Observation Only | |
Hemorrhage | 2|
Infiltration Cellular, Lymphocyte | |
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 3| 5|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 7| 0| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 8|
| 5| 2| 3| 1| 3| 0| 8| 3| 1| 6| 9| 0| 2| 3| 0| 4| 0| 1| 3| 6| 1| 0| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
0.25 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/M3 | 3| 5| 6| 7| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + M M|
Concretion | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + + + + A|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + M + + + + + A|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Autolysis | 4 |
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Autolysis | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | |
Inflammation | 3 |
Necrosis, Diffuse | 4 |
Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
Amyloid Deposition | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hyperplasia, Squamous | |
Inflammation | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + I + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 3| 5|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 7| 0| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 8|
| 5| 2| 3| 1| 3| 0| 8| 3| 1| 6| 9| 0| 2| 3| 0| 4| 0| 1| 3| 6| 1| 0| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
0.25 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/M3 | 3| 5| 6| 7| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Parathyroid Gland | M M + + M + + + + + + + + + + M + + + + + M + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Hyperplasia | 2 1 1 3 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Cystic | 1 1 1 1 2 1 1 2 2 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + + +|
Abdominal, Inflammation | |
Mediastinum, Infiltration Cellular, | |
Lymphocyte | 2 |
Mediastinum, Inflammation | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Ectasia | 1 3 |
Hyperplasia, Squamous | 3 |
Inflammation | 2 2 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Hemorrhage | |
Bilateral, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 3 |
Inflammation | |
Thrombosis | X |
Endometrium, Hyperplasia | 3 3 2 2 2 1 2 3 2 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myelofibrosis | 1 3 1 2 2 1 2 1 1 2 1 1 1 2 1 1 1 2 |
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + |
Iliac, Hyperplasia, Lymphoid | 3 |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + I + + + + + +|
Amyloid Deposition | |
Congestion | |
Hyperplasia, Lymphoid | 1 1 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + I + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 3| 5|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 7| 0| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 8|
| 5| 2| 3| 1| 3| 0| 8| 3| 1| 6| 9| 0| 2| 3| 0| 4| 0| 1| 3| 6| 1| 0| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
0.25 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/M3 | 3| 5| 6| 7| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Plasma Cell | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + A + + + + I + + + A|
Congestion | 1 3 |
Hyperplasia, Histiocytic | 1 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M M + M + + + M + M M + + + + M M M M M M + +|
Hyperplasia, Plasma Cell | |
Inflammation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + A + + + + + + + + +|
Congestion | 2 |
Hematopoietic Cell Proliferation | 3 2 3 2 |
Hyperplasia, Lymphoid | 1 1 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + M + + + + + + + + + + + +|
Atrophy | 3 3 1 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Dermis, Fibrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 3 1 |
Pons, Degeneration | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + M + + + + + + + + + + + + + + + + I +|
Inflammation | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Emphysema | |
Hemorrhage | 2 |
Hyperplasia, Macrophage | 1 1 1 1 1 1 1 1 1 |
Inflammation, Chronic Active | |
Inflammation | |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 3| 5|
DAY ON TEST | 3| 3| 3| 1| 3| 3| 7| 0| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 9| 8|
| 5| 2| 3| 1| 3| 0| 8| 3| 1| 6| 9| 0| 2| 3| 0| 4| 0| 1| 3| 6| 1| 0| 2| 8| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|
0.25 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
MG/M3 | 3| 5| 6| 7| 9| 0| 1| 2| 5| 7| 8| 9| 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 4| 5| 6|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia | 1 1 1 |
Interstitium, Infiltration Cellular | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Degeneration | 1 1 1 |
Olfactory Epithelium, Inflammation | |
Respiratory Epithelium, Degeneration | 1 1 2 1 1 |
Respiratory Epithelium, Inflammation | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Hemorrhage | |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Mineralization | |
Nephropathy | 3 |
Glomerulus, Inflammation | |
Renal Tubule, Necrosis, Acute | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3|
Calculus Micro Observation Only | |
Hemorrhage | |
Infiltration Cellular, Lymphocyte | 3 |
Transitional Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 8| 7| 3| 3| 3| 1| 3| 3| 3| 7| | |
| 3| 5| 3| 6| 0| 1| 6| 0| 3| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25 | 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/M3 | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | M + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + M | 55 |
Concretion | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 57 |
Autolysis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A | 57 |
Autolysis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
Autolysis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 58 |
Autolysis | | 1 4.0|
Peyer's Patch, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
Autolysis | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Autolysis | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation | | 1 3.0|
Necrosis, Diffuse | 3 | 4 3.3|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Amyloid Deposition | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Hyperplasia, Squamous | | 1 1.0|
Inflammation | 2 | 2 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Tooth | | 2 |
Peridontal Tissue, Inflammation | | 2 1.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | M + + + + + + + + + | 59 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 8| 7| 3| 3| 3| 1| 3| 3| 3| 7| | |
| 3| 5| 3| 6| 0| 1| 6| 0| 3| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25 | 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/M3 | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
Capsule, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + M + | 56 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M + + + + M | 44 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 56 |
Pars Distalis, Angiectasis | | 2 3.0|
Pars Distalis, Hyperplasia | 1 | 8 1.4|
__________________________________________________________________________|____________|
Thyroid Gland | M + + + + + + + + + | 59 |
Follicular Cell, Hyperplasia, Cystic | 2 1 1 | 20 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 8 |
Abdominal, Inflammation | | 1 2.0|
Mediastinum, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
Mediastinum, Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 56 |
Ectasia | | 4 1.5|
Hyperplasia, Squamous | | 1 3.0|
Inflammation | 1 | 4 2.3|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 58 |
Cyst | X X X | 8 |
Hemorrhage | | 1 4.0|
Bilateral, Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 1 3.0|
Inflammation | 3 | 1 3.0|
Thrombosis | | 1 |
Endometrium, Hyperplasia | 4 3 3 | 25 2.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Myelofibrosis | 1 3 1 1 2 1 1 | 43 1.5|
Myeloid Cell, Hyperplasia | 2 3 | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 8| 7| 3| 3| 3| 1| 3| 3| 3| 7| | |
| 3| 5| 3| 6| 0| 1| 6| 0| 3| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25 | 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/M3 | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Iliac, Hyperplasia, Lymphoid | 3 | 3 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
Renal, Hyperplasia, Lymphoid | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + + + + | 54 |
Amyloid Deposition | | 1 2.0|
Congestion | | 1 3.0|
Hyperplasia, Lymphoid | 3 1 | 9 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + | 56 |
Hyperplasia, Histiocytic | 2 | 2 2.0|
Hyperplasia, Lymphoid | 2 1 | 6 1.5|
Hyperplasia, Plasma Cell | 4 | 5 2.4|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + I | 52 |
Congestion | | 3 2.0|
Hyperplasia, Histiocytic | | 1 1.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M + M + M + + M | 28 |
Hyperplasia, Plasma Cell | 1 | 1 1.0|
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 58 |
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | 2 3 | 9 2.2|
Hyperplasia, Lymphoid | 1 | 4 1.3|
__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + | 54 |
Atrophy | 2 4 | 11 2.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 58 |
Ectasia | | 2 1.5|
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Skin | + + + I + + + + + + | 59 |
Inflammation | | 1 2.0|
Dermis, Fibrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Femur, Hyperostosis | | 1 1.0|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 8| 7| 3| 3| 3| 1| 3| 3| 3| 7| | |
| 3| 5| 3| 6| 0| 1| 6| 0| 3| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25 | 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/M3 | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Compression | | 5 2.4|
Pons, Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | M + + + + + + + + + | 56 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Emphysema | | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Macrophage | 2 1 1 1 1 | 24 1.3|
Inflammation, Chronic Active | | 7 1.3|
Inflammation | 2 | 1 2.0|
Mineralization | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 1 | 9 1.0|
Interstitium, Infiltration Cellular | | 4 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Olfactory Epithelium, Atrophy | | 2 1.0|
Olfactory Epithelium, Degeneration | 1 | 8 1.0|
Olfactory Epithelium, Inflammation | | 1 1.0|
Respiratory Epithelium, Degeneration | 1 1 | 14 1.1|
Respiratory Epithelium, Inflammation | 4 | 7 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Inflammation | 2 | 1 2.0|
Mineralization | 2 | 2 1.5|
Nephropathy | | 1 3.0|
Glomerulus, Inflammation | | 1 3.0|
Renal Tubule, Necrosis, Acute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 4| 3| 7| 7| 7| 7| 7| 7| 7| 6| | |
DAY ON TEST | 8| 7| 3| 3| 3| 1| 3| 3| 3| 7| | |
| 3| 5| 3| 6| 0| 1| 6| 0| 3| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25 | 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/M3 | 7| 9| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
Calculus Micro Observation Only | X | 1 |
Hemorrhage | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 4| 2| 2| 4| 4| 4| 4| 2| 2| 2| 4| 2| 4| 2| 2| 2| 4| 4| 2| 4| | |
DAY ON TEST | 5| 0| 0| 5| 5| 5| 5| 0| 0| 0| 5| 0| 5| 0| 0| 0| 5| 5| 0| 5| | |
| 9| 7| 7| 9| 9| 9| 9| 7| 7| 7| 9| 7| 9| 7| 7| 7| 9| 9| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
.25MG/M3 | 4| 5| 5| 5| 6| 6| 7| 7| 7| 8| 8| 8| 9| 9| 0| 0| 0| 1| 1| 1| | L |
LUNG TOX | 2| 1| 4| 5| 5| 9| 2| 4| 8| 3| 4| 6| 5| 6| 0| 3| 8| 0| 1| 3| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + I + + + | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + | 3 |
Cyst | 1 | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
Follicular Cell, Hyperplasia, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Ovary | + + + + + | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + | 7 |
Endometrium, Hyperplasia | 1 1 2 1 2 3 | 6 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + + + + + + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 4| 2| 2| 4| 4| 4| 4| 2| 2| 2| 4| 2| 4| 2| 2| 2| 4| 4| 2| 4| | |
DAY ON TEST | 5| 0| 0| 5| 5| 5| 5| 0| 0| 0| 5| 0| 5| 0| 0| 0| 5| 5| 0| 5| | |
| 9| 7| 7| 9| 9| 9| 9| 7| 7| 7| 9| 7| 9| 7| 7| 7| 9| 9| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | A |
.25MG/M3 | 4| 5| 5| 5| 6| 6| 7| 7| 7| 8| 8| 8| 9| 9| 0| 0| 0| 1| 1| 1| | L |
LUNG TOX | 2| 1| 4| 5| 5| 9| 2| 4| 8| 3| 4| 6| 5| 6| 0| 3| 8| 0| 1| 3| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + | 7 |
Hyperplasia, Lymphoid | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + M + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + I M + M I + M | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
__________________________________________________________________________|____________|
Thymus | M + + M + | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
Subcutaneous Tissue, Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + I + + | 4 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hyperplasia, Macrophage | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Inflammation, Acute | 1 1 1 1 | 4 1.0|
Respiratory Epithelium, Degeneration | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3|
| 2| 6| 1| 3| 0| 0| 1| 2| 0| 0| 0| 2| 2| 0| 0| 4| 2| 6| 6| 2| 7| 0| 3| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + M M + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Infarct | |
Necrosis, Diffuse | 2 |
Necrosis | |
__________________________________________________________________________|
Mesentery | + |
Inflammation, Chronic | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Inflammation | 2 |
Duct, Cyst, Multiple | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 1 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M M + + + + + M + + M + + + + + + M + + +|
Cyst | X |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Angiectasis | 1 |
Cyst | |
Pars Distalis, Angiectasis | 2 4 2 |
Pars Distalis, Hyperplasia | 1 2 1 1 1 3 2 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3|
| 2| 6| 1| 3| 0| 0| 1| 2| 0| 0| 0| 2| 2| 0| 0| 4| 2| 6| 6| 2| 7| 0| 3| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Cystic | 3 2 2 3 1 1 2 2 1 1 1 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Abdominal, Cyst | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + + + + + + I + + M + M + M + + +|
Atrophy | 1 |
Ectasia | 1 1 1 2 1 |
Inflammation | |
Pigmentation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Bilateral, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 |
Endometrium, Hyperplasia | 3 1 2 2 3 3 2 3 1 2 1 1 1|
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | |
Myelofibrosis | 2 1 3 1 1 2 2 3 2 2 2 2 1 1 2 1 1 1 1 2 1 1|
Myeloid Cell, Hyperplasia | 1 1 |
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | 2 |
Pancreatic, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + I + + + +|
Hyperplasia, Lymphoid | 2 1 2 2 1 |
Hyperplasia, Macrophage | 1 1 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Hyperplasia, Lymphoid | 3 2 |
Hyperplasia, Mast Cell | |
Hyperplasia, Plasma Cell | 2 2 3 4 |
__________________________________________________________________________|
Lymph Node, Mesenteric | I + + + + + + + + + + + + + + + I + + + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | 2 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + I + + + + M M M M + + M + M M + + + + + M +|
Hyperplasia, Histiocytic | 1 2 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3|
| 2| 6| 1| 3| 0| 0| 1| 2| 0| 0| 0| 2| 2| 0| 0| 4| 2| 6| 6| 2| 7| 0| 3| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Congestion | 1 |
Hematopoietic Cell Proliferation | 2 2 2 3 |
Hyperplasia, Lymphoid | 2 1 1 2 1 2 |
__________________________________________________________________________|
Thymus | + + + M + M + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + I|
Inflammation | |
Dermis, Fibrosis | |
Dermis, Inflammation, Granulomatous | |
Neck, Inflammation | 4 |
Pinna, Inflammation | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibula, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 1 3 |
Cerebrum, Degeneration | 3 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 1 |
Hyperplasia, Macrophage | 1 1 1 2 2 1 1 1 3 1 1 1 2 2 1 2 1 1 2 1 1 1 1 1|
Inflammation, Chronic Active | 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Alveolus, Proteinosis | 2 1 1 2 1 1 |
Interstitium, Infiltration Cellular | 1 1 1 1 2 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Degeneration | 1 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 3| 6| 7| 7| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 7| 3| 3| 3| 7| 3| 3| 3| 3|
| 2| 6| 1| 3| 0| 0| 1| 2| 0| 0| 0| 2| 2| 0| 0| 4| 2| 6| 6| 2| 7| 0| 3| 3| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Degeneration | 1 1 |
Respiratory Epithelium, Inflammation | 1 2 1 1 2 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 3 |
Squamous Epithelium, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
External Ear, Inflammation | 4 4 |
__________________________________________________________________________|
Harderian Gland | + + |
__________________________________________________________________________|
Lacrimal Gland | |
Extraorbital, Hyperplasia, Plasma | |
Cell | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Metaplasia, Osseous | |
Nephropathy | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 6|
DAY ON TEST | 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 1| 6| 3| 3| 8|
| 2| 6| 9| 2| 1| 6| 1| 3| 0| 2| 3| 6| 6| 1| 6| 9| 3| 4| 6| 1| 4| 7| 6| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
MG/M3 | 9| 0| 1| 2| 5| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + I + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + I + + + + + + + I + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Inflammation | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A M + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 2 |
Infarct | 3 |
Necrosis, Diffuse | |
Necrosis | |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation, Chronic | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Inflammation | |
Duct, Cyst, Multiple | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + I + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + M + + + + + + + + + + M + + + + + M + +|
Cyst | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X |
Pars Distalis, Angiectasis | 3 3 4 3 2 |
Pars Distalis, Hyperplasia | 3 3 2 2 1 3 1 1 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 6|
DAY ON TEST | 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 1| 6| 3| 3| 8|
| 2| 6| 9| 2| 1| 6| 1| 3| 0| 2| 3| 6| 6| 1| 6| 9| 3| 4| 6| 1| 4| 7| 6| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
MG/M3 | 9| 0| 1| 2| 5| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Cystic | 1 1 2 1 1 4 1 3 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
Abdominal, Cyst | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + M + + + + + + + + + M + + +|
Atrophy | |
Ectasia | |
Inflammation | 4 4 |
Pigmentation | 2 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X X |
Bilateral, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Endometrium, Hyperplasia | 2 2 1 3 2 1 1 1 1 4 1 3 2 3 3 1 1 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 2 |
Myelofibrosis | 3 2 2 1 2 1 1 1 3 1 1 1 2 1 1 3 2 2 3 3|
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Iliac, Hyperplasia, Lymphoid | 2 |
Inguinal, Hyperplasia, Lymphoid | 3 |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Lymphoid | 1 1 1 3 2 1 2 1 2|
Hyperplasia, Macrophage | 1 1 1 2 1 1 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Lymphoid | 3 1 2 |
Hyperplasia, Mast Cell | |
Hyperplasia, Plasma Cell | 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +|
Congestion | |
Hyperplasia, Lymphoid | 3 1|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + + M + + M + + + M + + + I M M M M + + M + +|
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 6|
DAY ON TEST | 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 1| 6| 3| 3| 8|
| 2| 6| 9| 2| 1| 6| 1| 3| 0| 2| 3| 6| 6| 1| 6| 9| 3| 4| 6| 1| 4| 7| 6| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
MG/M3 | 9| 0| 1| 2| 5| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | |
Hematopoietic Cell Proliferation | 1 2 1 2|
Hyperplasia, Lymphoid | 3 2 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + M + + + + M +|
Atrophy | 1 3 1 1 3 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 |
Dermis, Fibrosis | 1 |
Dermis, Inflammation, Granulomatous | 2 |
Neck, Inflammation | |
Pinna, Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibula, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | + + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Cerebrum, Degeneration | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + I + + + + + + + I + + + + +|
Hyperplasia | 1 |
Inflammation | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | |
Hyperplasia, Macrophage | 3 1 1 2 2 3 2 1 2 1 2 2 1 1 1 1 2 2 2 1 2 2|
Inflammation, Chronic Active | 2 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Alveolus, Proteinosis | 1 1 1 |
Interstitium, Infiltration Cellular | 2 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration | |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 6| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 5| 7| 7| 6|
DAY ON TEST | 7| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 1| 6| 3| 3| 8|
| 2| 6| 9| 2| 1| 6| 1| 3| 0| 2| 3| 6| 6| 1| 6| 9| 3| 4| 6| 1| 4| 7| 6| 6| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
0.5 | 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|
MG/M3 | 9| 0| 1| 2| 5| 9| 0| 1| 2| 3| 5| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 0| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Respiratory Epithelium, Degeneration | 1 1 |
Respiratory Epithelium, Inflammation | 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
Squamous Epithelium, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
External Ear, Inflammation | |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Lacrimal Gland | + |
Extraorbital, Hyperplasia, Plasma | |
Cell | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2|
Metaplasia, Osseous | 1 |
Nephropathy | 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| | |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 2| 1| 3| | |
| 1| 6| 2| 0| 1| 6| 3| 9| 4| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/M3 | 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + I + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 2 2.5|
Infarct | | 1 3.0|
Necrosis, Diffuse | | 1 2.0|
Necrosis | 3 1 | 2 2.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Inflammation, Chronic | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Inflammation | | 1 2.0|
Duct, Cyst, Multiple | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperplasia, Squamous | | 2 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Inflammation | | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + + + | 50 |
Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| | |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 2| 1| 3| | |
| 1| 6| 2| 0| 1| 6| 3| 9| 4| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/M3 | 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Angiectasis | | 1 1.0|
Cyst | | 1 |
Pars Distalis, Angiectasis | | 8 2.9|
Pars Distalis, Hyperplasia | | 15 1.8|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Hyperplasia, Cystic | 1 1 1 | 27 1.7|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 4 |
Abdominal, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 52 |
Atrophy | | 1 1.0|
Ectasia | | 5 1.2|
Inflammation | 2 | 3 3.3|
Pigmentation | | 2 1.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | X X X X | 17 |
Bilateral, Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Dilatation | | 1 2.0|
Endometrium, Hyperplasia | 3 3 3 3 3 3 3 3 | 39 2.1|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia, Histiocytic | | 1 2.0|
Myelofibrosis | 1 2 1 2 2 2 2 3 1 1 | 52 1.7|
Myeloid Cell, Hyperplasia | | 2 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + | 13 |
Iliac, Hyperplasia, Lymphoid | | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | | 2 2.5|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 58 |
Hyperplasia, Lymphoid | 3 1 | 16 1.6|
Hyperplasia, Macrophage | 1 1 | 14 1.1|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| | |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 2| 1| 3| | |
| 1| 6| 2| 0| 1| 6| 3| 9| 4| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/M3 | 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Cyst | | 1 1.0|
Hyperplasia, Lymphoid | | 5 2.2|
Hyperplasia, Mast Cell | 3 | 1 3.0|
Hyperplasia, Plasma Cell | | 5 2.8|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M | 56 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M + I M M M + + | 33 |
Hyperplasia, Histiocytic | | 2 1.5|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Angiectasis | | 1 1.0|
Congestion | | 1 1.0|
Hematopoietic Cell Proliferation | | 8 1.9|
Hyperplasia, Lymphoid | | 9 1.7|
__________________________________________________________________________|____________|
Thymus | + + + + I + + + + + | 54 |
Atrophy | | 8 1.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Inflammation | | 1 4.0|
Dermis, Fibrosis | | 1 1.0|
Dermis, Inflammation, Granulomatous | | 1 2.0|
Neck, Inflammation | | 1 4.0|
Pinna, Inflammation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibula, Fracture | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + M + | 59 |
Compression | | 3 2.3|
Cerebrum, Degeneration | | 3 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| | |
DAY ON TEST | 8| 3| 3| 3| 3| 3| 3| 2| 1| 3| | |
| 1| 6| 2| 0| 1| 6| 3| 9| 4| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/M3 | 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hyperplasia | 4 | 2 2.5|
Inflammation | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Hemorrhage | 1 | 3 1.0|
Hyperplasia, Macrophage | 1 1 3 2 2 2 2 | 53 1.5|
Inflammation, Chronic Active | 1 | 14 1.1|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 1 1 | 32 1.0|
Alveolus, Proteinosis | 3 1 | 11 1.4|
Interstitium, Infiltration Cellular | 1 1 1 1 | 16 1.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Olfactory Epithelium, Atrophy | | 1 1.0|
Olfactory Epithelium, Degeneration | | 1 1.0|
Respiratory Epithelium, Degeneration | | 4 1.0|
Respiratory Epithelium, Inflammation | 1 1 1 | 11 1.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 3 1.7|
Squamous Epithelium, Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
External Ear, Inflammation | | 2 4.0|
__________________________________________________________________________|____________|
Harderian Gland | + | 4 |
__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
Extraorbital, Hyperplasia, Plasma | | |
Cell | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Inflammation | | 1 2.0|
Metaplasia, Osseous | | 1 1.0|
Nephropathy | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | A + + + + + + + + + | 58 |
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 2| 2| 4| 2| 4| 4| 2| 2| 4| 2| 4| 2| 4| 4| 2| 4| 2| 4| 2| 4| | |
DAY ON TEST | 0| 0| 5| 0| 5| 5| 0| 0| 5| 0| 5| 0| 5| 5| 0| 5| 0| 5| 0| 5| | |
| 7| 7| 9| 7| 9| 9| 7| 7| 9| 7| 9| 7| 9| 9| 7| 9| 7| 9| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5MG/M3 | 0| 1| 2| 3| 3| 3| 3| 3| 4| 4| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| | L |
LUNG TOX | 9| 6| 0| 3| 4| 6| 7| 8| 4| 6| 1| 9| 1| 2| 3| 4| 5| 6| 0| 1| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
Pars Distalis, Hyperplasia, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Ovary | + + + + + | 5 |
Cyst | X | 1 |
Periovarian Tissue, Cyst | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + | 6 |
Endometrium, Hyperplasia | 1 1 3 2 3 | 5 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 2| 2| 4| 2| 4| 4| 2| 2| 4| 2| 4| 2| 4| 4| 2| 4| 2| 4| 2| 4| | |
DAY ON TEST | 0| 0| 5| 0| 5| 5| 0| 0| 5| 0| 5| 0| 5| 5| 0| 5| 0| 5| 0| 5| | |
| 7| 7| 9| 7| 9| 9| 7| 7| 9| 7| 9| 7| 9| 9| 7| 9| 7| 9| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5MG/M3 | 0| 1| 2| 3| 3| 3| 3| 3| 4| 4| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| | L |
LUNG TOX | 9| 6| 0| 3| 4| 6| 7| 8| 4| 6| 1| 9| 1| 2| 3| 4| 5| 6| 0| 1| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + I + | 9 |
Hyperplasia, Lymphoid | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 6 |
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M + M M M M M | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + I + I I | 2 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hyperplasia, Macrophage | 1 1 1 | 3 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Inflammation, Acute | 1 | 1 1.0|
Olfactory Epithelium, Degeneration | 1 | 1 1.0|
Olfactory Epithelium, Respiratory | | |
Epithelium, Degeneration | 1 | 1 1.0|
Respiratory Epithelium, Degeneration | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 2| 2| 4| 2| 4| 4| 2| 2| 4| 2| 4| 2| 4| 4| 2| 4| 2| 4| 2| 4| | |
DAY ON TEST | 0| 0| 5| 0| 5| 5| 0| 0| 5| 0| 5| 0| 5| 5| 0| 5| 0| 5| 0| 5| | |
| 7| 7| 9| 7| 9| 9| 7| 7| 9| 7| 9| 7| 9| 9| 7| 9| 7| 9| 7| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.5MG/M3 | 0| 1| 2| 3| 3| 3| 3| 3| 4| 4| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| | L |
LUNG TOX | 9| 6| 0| 3| 4| 6| 7| 8| 4| 6| 1| 9| 1| 2| 3| 4| 5| 6| 0| 1| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 2| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 1| 5| 3| 3| 3| 6| 3| 8| 3| 3| 3| 3| 2| 6| 3|
| 2| 2| 3| 9| 6| 4| 2| 2| 2| 2| 3| 7| 6| 6| 2| 1| 0| 1| 2| 3| 2| 1| 8| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
MG/M3 | 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + I M + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M M + M + I I + + + + + + I + M + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | |
Infarct | |
Necrosis, Diffuse | 1 |
Necrosis | 2 2 |
Bile Duct, Degeneration | |
__________________________________________________________________________|
Mesentery | + + + |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation | 2 |
Necrosis | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | |
Hypertrophy | |
Extra Adrenal Tissue, Inflammation | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + M + + + + + + + + + + M M +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + I + + + + + + + I +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 2| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 1| 5| 3| 3| 3| 6| 3| 8| 3| 3| 3| 3| 2| 6| 3|
| 2| 2| 3| 9| 6| 4| 2| 2| 2| 2| 3| 7| 6| 6| 2| 1| 0| 1| 2| 3| 2| 1| 8| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
MG/M3 | 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Congestion | 3 |
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia | 2 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Follicular Cell, Hyperplasia, Cystic | 1 1 2 2 1 2 3 2 1 1 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Abdominal, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 |
Inflammation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 2 |
Cyst | X X |
Hemorrhage | 4 2 |
Inflammation | 4 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation | 3 |
Prolapse | |
Endometrium, Hyperplasia | 3 1 2 2 1 3 1 2 1 2 3 2 3 2 1 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | |
Myelofibrosis | 1 2 1 2 1 1 1 1 1 1 2 1 2 3 1 2 2|
Myeloid Cell, Hyperplasia | 1 |
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Plasma Cell | 3 |
Inguinal, Hyperplasia, Histiocytic | |
Inguinal, Hyperplasia, Lymphoid | 1 |
Inguinal, Pigmentation | 2 |
Pancreatic, Hematopoietic Cell | |
Proliferation | |
Pancreatic, Inflammation | 1 |
Renal, Fibrosis | |
Renal, Hyperplasia, Histiocytic | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 2| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 1| 5| 3| 3| 3| 6| 3| 8| 3| 3| 3| 3| 2| 6| 3|
| 2| 2| 3| 9| 6| 4| 2| 2| 2| 2| 3| 7| 6| 6| 2| 1| 0| 1| 2| 3| 2| 1| 8| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
MG/M3 | 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | I + + + + + + + + + + + + M + I + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 2 1 4 2 3 1 2 3 1 3 2 2 2|
Hyperplasia, Macrophage | 1 1 1 1 1 1 1 1 2 2 2 2 3 1 1 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + M + + + M|
Cyst | X |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 1 |
Hyperplasia, Plasma Cell | 3 |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + M + M + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
Inflammation | 1 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + I I M + I + + + M M + I I M M M M + + I + M M|
Hyperplasia, Lymphoid | 1 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 |
Hyperplasia, Lymphoid | 2 3 1 1 1 1 1 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Thymus | + + + I + + + + + + + + + M + + + + + + + + + + +|
Atrophy | 2 3 3 3 1 |
Autolysis | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 4 |
Pinna, Inflammation | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + I + + + + + + + + + + I + + + + + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| 2| 7| 7| 7| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 7| 3| 1| 3| 3| 3| 3| 1| 5| 3| 3| 3| 6| 3| 8| 3| 3| 3| 3| 2| 6| 3|
| 2| 2| 3| 9| 6| 4| 2| 2| 2| 2| 3| 7| 6| 6| 2| 1| 0| 1| 2| 3| 2| 1| 8| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
1.0 | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
MG/M3 | 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 7| 8| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Degeneration | |
Hyperplasia | |
Inflammation | 3 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Macrophage | 3 1 2 3 2 2 2 2 2 2 4 2 2 2 3 2 2 2 3 3 3 3 3 3 3|
Inflammation, Chronic Active | 1 2 2 2 1 1 1 3 2 1 1 1 1 2 2 1 3|
Alveolar Epithelium, Hyperplasia | 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Metaplasia, | |
Squamous | |
Alveolus, Proteinosis | 3 2 3 2 2 1 1 3 2 3 1 1 2 1 1 1 2 4 3|
Bronchiole, Degeneration | |
Interstitium, Infiltration Cellular | 2 1 1 1 2 2 2 2 1 2 1 1 1 1 1 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy | 1 1 1 1 1 1 1 |
Olfactory Epithelium, Degeneration | 1 1 1 1 1 1|
Olfactory Epithelium, Inflammation | 1 1 |
Respiratory Epithelium, Degeneration | 1 1 1 1 |
Respiratory Epithelium, Inflammation | 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
Squamous Epithelium, Hyperplasia | |
Squamous Epithelium, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Nephropathy | 1 |
Pelvis, Dilatation | 1 |
Perirenal Tissue, Inflammation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 3| 7| 7| 6| 7| 7| 7| 7| 3| 6| 5| 5| 5| 6| 3| 7| 7| 5| 6| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 6| 3| 3| 3| 3| 7| 0| 6| 1| 2| 9| 1| 3| 3| 7| 0| 3| 9| 3| 3| 3| 3|
| 3| 0| 3| 9| 0| 1| 6| 3| 0| 1| 2| 6| 1| 8| 0| 1| 1| 1| 4| 6| 6| 0| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
MG/M3 | 3| 4| 5| 6| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + M + + + + + + A A M + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + I + + + + + + + + + + + + + + + + + I I + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | 3 |
Hematopoietic Cell Proliferation | |
Infarct | 4 |
Necrosis, Diffuse | 4 1 2 3 |
Necrosis | |
Bile Duct, Degeneration | 2 |
__________________________________________________________________________|
Mesentery | |
Infiltration Cellular, Lymphocyte | |
Inflammation | |
Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia | |
Hypertrophy | 2 |
Extra Adrenal Tissue, Inflammation | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M M M M + + + + M + + + I + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 3| 7| 7| 6| 7| 7| 7| 7| 3| 6| 5| 5| 5| 6| 3| 7| 7| 5| 6| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 6| 3| 3| 3| 3| 7| 0| 6| 1| 2| 9| 1| 3| 3| 7| 0| 3| 9| 3| 3| 3| 3|
| 3| 0| 3| 9| 0| 1| 6| 3| 0| 1| 2| 6| 1| 8| 0| 1| 1| 1| 4| 6| 6| 0| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
MG/M3 | 3| 4| 5| 6| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Congestion | |
Pars Distalis, Angiectasis | 4 |
Pars Distalis, Hyperplasia | 3 1 3 3 3 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 |
Follicular Cell, Hyperplasia, Cystic | 1 1 1 1 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Abdominal, Inflammation | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Inflammation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + M + + + + + + + + + + + + +|
Angiectasis | 3 |
Atrophy | |
Cyst | X X X X|
Hemorrhage | |
Inflammation | |
Pigmentation, Hemosiderin | 1 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation | |
Prolapse | |
Endometrium, Hyperplasia | 2 3 3 3 3 3 3 2 1 4 3 2 3 1 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | |
Myelofibrosis | 1 1 1 1 2 3 1 2 1 1 3 1 3 1 1 1 2|
Myeloid Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Iliac, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Plasma Cell | 4 |
Inguinal, Hyperplasia, Histiocytic | |
Inguinal, Hyperplasia, Lymphoid | |
Inguinal, Pigmentation | |
Pancreatic, Hematopoietic Cell | |
Proliferation | 2 |
Pancreatic, Inflammation | |
Renal, Fibrosis | |
Renal, Hyperplasia, Histiocytic | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 3| 7| 7| 6| 7| 7| 7| 7| 3| 6| 5| 5| 5| 6| 3| 7| 7| 5| 6| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 6| 3| 3| 3| 3| 7| 0| 6| 1| 2| 9| 1| 3| 3| 7| 0| 3| 9| 3| 3| 3| 3|
| 3| 0| 3| 9| 0| 1| 6| 3| 0| 1| 2| 6| 1| 8| 0| 1| 1| 1| 4| 6| 6| 0| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
MG/M3 | 3| 4| 5| 6| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Renal, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hemorrhage | |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 1 1 2 2 1 2 2 1 2|
Hyperplasia, Macrophage | 1 2 3 1 1 1 1 1 1 2 1 2 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
Cyst | |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 1 3 2 3 |
Hyperplasia, Plasma Cell | 4 |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + M + + M + + + + + + + + + + M + + +|
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 2 |
Inflammation | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + + I M + M M M + M I M M M + + M M + + M M M|
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3 4 2 |
Hyperplasia, Lymphoid | 1 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 3 2 2 |
Autolysis | 3 |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
Pinna, Inflammation | 4 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + I + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 3| 7| 7| 6| 7| 7| 7| 7| 3| 6| 5| 5| 5| 6| 3| 7| 7| 5| 6| 7| 5| 7| 7| 7| 7|
DAY ON TEST | 9| 3| 3| 6| 3| 3| 3| 3| 7| 0| 6| 1| 2| 9| 1| 3| 3| 7| 0| 3| 9| 3| 3| 3| 3|
| 3| 0| 3| 9| 0| 1| 6| 3| 0| 1| 2| 6| 1| 8| 0| 1| 1| 1| 4| 6| 6| 0| 2| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1.0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2|
MG/M3 | 3| 4| 5| 6| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Degeneration | 1 |
Hyperplasia | |
Inflammation | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 1 |
Hyperplasia, Macrophage | 2 2 2 2 2 3 2 3 2 3 3 2 2 1 2 2 3 2 3 2 2 2 2 2|
Inflammation, Chronic Active | 2 1 1 1 3 2 3 1 1 2 2 2 1 3 2 1 |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
Alveolar Epithelium, Metaplasia, | |
Squamous | 2 |
Alveolus, Proteinosis | 2 1 1 3 2 2 2 2 2 1 3 1 3 2 2 2 1 |
Bronchiole, Degeneration | 1 1 |
Interstitium, Infiltration Cellular | 1 2 1 1 1 2 2 1 2 1 2 1 2 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy | 1 1 1 1 1 1 1 |
Olfactory Epithelium, Degeneration | 1 2 |
Olfactory Epithelium, Inflammation | |
Respiratory Epithelium, Degeneration | 1 1 |
Respiratory Epithelium, Inflammation | 3 2 2 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 2 |
Squamous Epithelium, Hyperplasia | 2 |
Squamous Epithelium, Inflammation | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + A + + + + + + + + + + + + + +|
Degeneration | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Nephropathy | 2 1 |
Pelvis, Dilatation | 2 |
Perirenal Tissue, Inflammation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + M + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 7| 3| 3| 5| 6| 3| 3| 3| 3| | |
| 0| 5| 6| 2| 9| 3| 1| 3| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
1.0 | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| | L |
MG/M3 | 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | I M + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Eosinophilic Focus | | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Infarct | | 1 4.0|
Necrosis, Diffuse | 3 | 6 2.3|
Necrosis | | 2 2.0|
Bile Duct, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation | | 1 2.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Inflammation | | 1 1.0|
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + M + + | 59 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Cyst | | 1 |
Hyperplasia | 2 | 1 2.0|
Hypertrophy | | 1 2.0|
Extra Adrenal Tissue, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 7| 3| 3| 5| 6| 3| 3| 3| 3| | |
| 0| 5| 6| 2| 9| 3| 1| 3| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
1.0 | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| | L |
MG/M3 | 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + | 49 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 57 |
Congestion | | 1 3.0|
Pars Distalis, Angiectasis | | 1 4.0|
Pars Distalis, Hyperplasia | 2 4 | 11 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Inflammation | | 2 1.0|
Follicular Cell, Hyperplasia, Cystic | 1 2 3 | 27 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 3 |
Abdominal, Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + I + + + M + | 58 |
Ectasia | | 2 2.0|
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Angiectasis | | 1 3.0|
Atrophy | | 1 2.0|
Cyst | X X | 8 |
Hemorrhage | | 2 3.0|
Inflammation | | 1 4.0|
Pigmentation, Hemosiderin | | 1 1.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hemorrhage | | 1 4.0|
Inflammation | | 1 3.0|
Prolapse | X | 1 |
Endometrium, Hyperplasia | 3 3 3 2 1 3 2 2 | 41 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia, Histiocytic | 2 | 1 2.0|
Myelofibrosis | 2 1 2 3 2 1 3 | 41 1.6|
Myeloid Cell, Hyperplasia | 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Lymph Node | + + + | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 7| 3| 3| 5| 6| 3| 3| 3| 3| | |
| 0| 5| 6| 2| 9| 3| 1| 3| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
1.0 | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| | L |
MG/M3 | 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Iliac, Hyperplasia, Lymphoid | 2 | 1 2.0|
Iliac, Hyperplasia, Plasma Cell | | 2 3.5|
Inguinal, Hyperplasia, Histiocytic | 3 | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | | 1 1.0|
Inguinal, Pigmentation | | 1 2.0|
Pancreatic, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Pancreatic, Inflammation | | 1 1.0|
Renal, Fibrosis | 4 | 1 4.0|
Renal, Hyperplasia, Histiocytic | 4 | 1 4.0|
Renal, Hyperplasia, Lymphoid | 3 | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 56 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Histiocytic | 4 | 1 4.0|
Hyperplasia, Lymphoid | 3 2 2 2 | 26 2.0|
Hyperplasia, Macrophage | 1 1 3 2 2 2 2 | 37 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + + | 55 |
Cyst | | 1 |
Hyperplasia, Histiocytic | 4 | 1 4.0|
Hyperplasia, Lymphoid | | 5 2.0|
Hyperplasia, Plasma Cell | 3 2 | 4 3.0|
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + + + + | 51 |
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | 3 | 2 2.5|
Inflammation | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | I + M + M M + M + M | 22 |
Hyperplasia, Lymphoid | | 3 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | 2 | 9 2.1|
Hyperplasia, Lymphoid | 1 | 10 1.5|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + | 56 |
Atrophy | 3 2 | 12 2.4|
Autolysis | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 7| 3| 3| 5| 6| 3| 3| 3| 3| | |
| 0| 5| 6| 2| 9| 3| 1| 3| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
1.0 | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| | L |
MG/M3 | 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation | | 3 3.0|
Pinna, Inflammation | | 1 4.0|
Subcutaneous Tissue, Edema | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Compression | | 2 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | I + + + + + + + + + | 56 |
Degeneration | | 1 1.0|
Hyperplasia | 4 | 1 4.0|
Inflammation | 2 | 2 2.5|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 1 1.0|
Hyperplasia, Macrophage | 3 2 2 3 2 3 2 2 3 3 | 59 2.4|
Inflammation, Chronic Active | 1 1 1 1 1 2 3 | 40 1.6|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 | 45 1.1|
Alveolar Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
Alveolus, Proteinosis | 2 1 1 3 3 2 2 1 2 | 45 1.9|
Bronchiole, Degeneration | | 2 1.0|
Interstitium, Infiltration Cellular | 2 1 1 1 1 1 2 2 | 39 1.4|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Olfactory Epithelium, Atrophy | 1 1 1 | 17 1.0|
Olfactory Epithelium, Degeneration | | 8 1.1|
Olfactory Epithelium, Inflammation | | 2 1.0|
Respiratory Epithelium, Degeneration | 1 | 7 1.0|
Respiratory Epithelium, Inflammation | 1 1 1 1 | 11 1.4|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 2 2.5|
Squamous Epithelium, Hyperplasia | | 1 2.0|
Squamous Epithelium, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 6| 4| 7| 7| 7| 7| | |
DAY ON TEST | 3| 7| 3| 3| 5| 6| 3| 3| 3| 3| | |
| 0| 5| 6| 2| 9| 3| 1| 3| 3| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
1.0 | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| | L |
MG/M3 | 6| 7| 9| 0| 1| 3| 4| 5| 6| 7| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Degeneration | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Fibrosis | | 1 1.0|
Nephropathy | | 3 1.3|
Pelvis, Dilatation | | 2 1.5|
Perirenal Tissue, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 4| 2| 2| 2| 4| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 4| 2| 4| 4| 4| | |
DAY ON TEST | 5| 0| 0| 0| 5| 0| 0| 0| 0| 0| 5| 5| 5| 5| 0| 5| 0| 5| 5| 5| | |
| 9| 7| 7| 7| 9| 7| 7| 7| 7| 7| 9| 9| 9| 9| 7| 9| 7| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
1.0MG/M3 | 6| 6| 6| 7| 7| 8| 8| 9| 0| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3| 4| | L |
LUNG TOX | 1| 2| 9| 6| 9| 2| 5| 7| 2| 3| 0| 1| 9| 4| 5| 8| 2| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + I + + + | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 6 |
Diverticulum | 2 | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + I | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + I + | 4 |
Pars Distalis, Hyperplasia, Focal | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 5 |
Ectasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + | 5 |
Cyst | 4 | 1 4.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + | 6 |
Endometrium, Hyperplasia | 2 2 2 2 2 | 5 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 4| 2| 2| 2| 4| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 4| 2| 4| 4| 4| | |
DAY ON TEST | 5| 0| 0| 0| 5| 0| 0| 0| 0| 0| 5| 5| 5| 5| 0| 5| 0| 5| 5| 5| | |
| 9| 7| 7| 7| 9| 7| 7| 7| 7| 7| 9| 9| 9| 9| 7| 9| 7| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
1.0MG/M3 | 6| 6| 6| 7| 7| 8| 8| 9| 0| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3| 4| | L |
LUNG TOX | 1| 2| 9| 6| 9| 2| 5| 7| 2| 3| 0| 1| 9| 4| 5| 8| 2| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + + + + + I | 8 |
Hyperplasia, Lymphoid | 2 2 1 1 2 2 1 | 7 1.6|
Hyperplasia, Macrophage | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 6 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Hyperplasia, Plasma Cell | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M + M + M | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + I | 4 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hyperplasia, Macrophage | 1 1 1 1 1 1 1 1 2 1 | 10 1.1|
Inflammation, Chronic Active | 1 1 2 1 1 1 1 | 7 1.1|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 | 5 1.0|
Alveolus, Proteinosis | 1 1 1 1 2 | 5 1.2|
Interstitium, Infiltration Cellular | 2 1 1 2 1 1 | 6 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Inflammation, Acute | 1 1 1 1 1 | 5 1.0|
Olfactory Epithelium, Atrophy | 1 | 1 1.0|
Respiratory Epithelium, Degeneration | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 4| 2| 2| 2| 4| 2| 2| 2| 2| 2| 4| 4| 4| 4| 2| 4| 2| 4| 4| 4| | |
DAY ON TEST | 5| 0| 0| 0| 5| 0| 0| 0| 0| 0| 5| 5| 5| 5| 0| 5| 0| 5| 5| 5| | |
| 9| 7| 7| 7| 9| 7| 7| 7| 7| 7| 9| 9| 9| 9| 7| 9| 7| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
1.0MG/M3 | 6| 6| 6| 7| 7| 8| 8| 9| 0| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3| 4| | L |
LUNG TOX | 1| 2| 9| 6| 9| 2| 5| 7| 2| 3| 0| 1| 9| 4| 5| 8| 2| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 2|
DAY ON TEST | 8| 8| 9| 3| 3| 7| 0| 1| 3| 8| 5| 3| 7| 7| 3| 3| 3| 2| 4| 7| 3| 3| 3| 0| 8|
| 8| 7| 8| 7| 8| 0| 7| 4| 7| 0| 5| 8| 3| 6| 8| 9| 9| 7| 2| 0| 9| 9| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3|
MG/M3 | 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 4| 6| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + I + + + + + + + + I + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
Clear Cell Focus | |
Congestion | 3 |
Infarct | 4 4 4 |
Necrosis, Diffuse | 4 3 |
Centrilobular, Degeneration | 2 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 3 2 |
Inflammation | 3 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M M + + + I + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | I + + + + + + + + + I + + + + + + + + M + + + + +|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Cystic | 3 1 1 2 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 2|
DAY ON TEST | 8| 8| 9| 3| 3| 7| 0| 1| 3| 8| 5| 3| 7| 7| 3| 3| 3| 2| 4| 7| 3| 3| 3| 0| 8|
| 8| 7| 8| 7| 8| 0| 7| 4| 7| 0| 5| 8| 3| 6| 8| 9| 9| 7| 2| 0| 9| 9| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3|
MG/M3 | 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 4| 6| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
Hyperplasia, Squamous | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Ectasia | 2 3 3 2 1 2 1 2 3 3 3 2 2 4 2 2 |
Inflammation | 3 2 2 2 2 2 2 3 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + M + + + + + +|
Inflammation | 2 2 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1|
Hemorrhage | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythroid Cell, Hyperplasia | |
Myeloid Cell, Hyperplasia | 1 3 2 1 3 2 3 1|
__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Iliac, Hyperplasia, Histiocytic | 2 |
Iliac, Hyperplasia, Lymphoid | 4 3 |
Iliac, Hyperplasia, Plasma Cell | 2 3 3 3 3 3|
Iliac, Pigmentation | 1 |
Inguinal, Hyperplasia, Lymphoid | 3 2 3|
Inguinal, Hyperplasia, Plasma Cell | 2 2 |
Inguinal, Inflammation | 1 |
Inguinal, Pigmentation | |
Lumbar, Hyperplasia, Plasma Cell | 3|
Popliteal, Hyperplasia, Plasma Cell | |
Renal, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Plasma Cell | 3 3|
Renal, Inflammation | 1|
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + + + + + M + + + M + I I + + I M + + + +|
Edema | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M M + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + I + + + + + + + + + + + I + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 2|
DAY ON TEST | 8| 8| 9| 3| 3| 7| 0| 1| 3| 8| 5| 3| 7| 7| 3| 3| 3| 2| 4| 7| 3| 3| 3| 0| 8|
| 8| 7| 8| 7| 8| 0| 7| 4| 7| 0| 5| 8| 3| 6| 8| 9| 9| 7| 2| 0| 9| 9| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3|
MG/M3 | 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 4| 6| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | 3 |
Inflammation | 3 3 1 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + M I + M M + M M + M M M M + M M + I M M M M|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 2 3 3 3|
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + M + + + + + +|
Atrophy | 1 3 1 3 1 1 1 4 4 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Foot, Inflammation | |
Foot, Necrosis | |
Prepuce, Hyperplasia, Squamous | |
Prepuce, Inflammation | 3 3 4 |
Subcutaneous Tissue, Inflammation | 4|
Tail, Hyperkeratosis | |
Tail, Inflammation | 3 3|
Tail, Necrosis | 4 4 4 4 4 4 4|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Fibrosis | |
Hyperplasia, Macrophage | 4 |
Inflammation, Chronic Active | 2 |
Inflammation | 2 |
Alveolar Epithelium, Hyperplasia | 1 |
Bronchiole, Hyperplasia | |
Interstitium, Infiltration Cellular | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 7| 5| 6| 5| 7| 5| 5| 7| 5| 6| 7| 7| 7| 6| 6| 5| 7| 7| 7| 6| 2|
DAY ON TEST | 8| 8| 9| 3| 3| 7| 0| 1| 3| 8| 5| 3| 7| 7| 3| 3| 3| 2| 4| 7| 3| 3| 3| 0| 8|
| 8| 7| 8| 7| 8| 0| 7| 4| 7| 0| 5| 8| 3| 6| 8| 9| 9| 7| 2| 0| 9| 9| 8| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3|
MG/M3 | 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 0| 1| 2| 4| 6| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Olfactory Epithelium, Inflammation | |
Respiratory Epithelium, Degeneration | |
Respiratory Epithelium, Inflammation | |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 2 3 3 3|
Nephropathy | 2 1 |
Pelvis, Dilatation | 2 1 3 3 3 4 |
Renal Tubule, Pigmentation | 3 |
__________________________________________________________________________|
Ureter | |
Dilatation | |
Inflammation | |
__________________________________________________________________________|
Urethra | + + + |
Calculus Micro Observation Only | X X X |
Inflammation | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Dilatation | |
Inflammation | 4 4 4 4 4|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 4| 6| 7| 7| 5| 6| 5| 5| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 8| 3| 5| 3| 3| 3| 0| 3| 4| 3| 5| 5| 1| 3| 3| 9| 1| 9| 6| 3| 1| 3|
| 7| 7| 7| 5| 9| 3| 8| 9| 9| 8| 9| 0| 4| 2| 2| 4| 9| 8| 7| 4| 7| 8| 7| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
MG/M3 | 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 8| 9| 0| 1| 3| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Gallbladder | + + + + + + + M + + + + + + + + + + M + M M + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
Clear Cell Focus | 2 |
Congestion | |
Infarct | 4 4 |
Necrosis, Diffuse | 1 2 4 |
Centrilobular, Degeneration | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Inflammation | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + + + I + + M + + + + + + I|
__________________________________________________________________________|
Pituitary Gland | + + + + M M + + + + + + M + + + + + + + + M + + +|
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Cystic | 1 1 1 2 1 1 3 1 1 2 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 4| 6| 7| 7| 5| 6| 5| 5| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 8| 3| 5| 3| 3| 3| 0| 3| 4| 3| 5| 5| 1| 3| 3| 9| 1| 9| 6| 3| 1| 3|
| 7| 7| 7| 5| 9| 3| 8| 9| 9| 8| 9| 0| 4| 2| 2| 4| 9| 8| 7| 4| 7| 8| 7| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
MG/M3 | 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 8| 9| 0| 1| 3| 6|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + |
Hyperplasia, Squamous | 3 4 |
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | 1 2 3 2 3 2 2 2 3 1 3 3 3 3 3 2 1 3 3 3 2 2 2 |
Inflammation | 3 4 4 3 4 3 4 3 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythroid Cell, Hyperplasia | |
Myeloid Cell, Hyperplasia | 2 1 3 3 1 2 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Iliac, Hyperplasia, Histiocytic | |
Iliac, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Plasma Cell | 3 3 3 4 2 |
Iliac, Pigmentation | |
Inguinal, Hyperplasia, Lymphoid | 2 3 |
Inguinal, Hyperplasia, Plasma Cell | 2 1 1 |
Inguinal, Inflammation | |
Inguinal, Pigmentation | 1 1 |
Lumbar, Hyperplasia, Plasma Cell | |
Popliteal, Hyperplasia, Plasma Cell | 3 |
Renal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | 3 |
Renal, Inflammation | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + I + + + + + + M M I + + + + + + + + + +|
Edema | |
Hyperplasia, Lymphoid | 1 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + I + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + M + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 4| 6| 7| 7| 5| 6| 5| 5| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 8| 3| 5| 3| 3| 3| 0| 3| 4| 3| 5| 5| 1| 3| 3| 9| 1| 9| 6| 3| 1| 3|
| 7| 7| 7| 5| 9| 3| 8| 9| 9| 8| 9| 0| 4| 2| 2| 4| 9| 8| 7| 4| 7| 8| 7| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
MG/M3 | 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 8| 9| 0| 1| 3| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Congestion | 1|
Inflammation | 2 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | I + + M + M M M + M M M M + M M M I M + M + M M I|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + M + + M + + + + + + + +|
Atrophy | 3 3 2 1 3 2 1 1 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 2 3 |
Foot, Inflammation | 4 |
Foot, Necrosis | 1 |
Prepuce, Hyperplasia, Squamous | 3 |
Prepuce, Inflammation | 2 4 4 3 4 |
Subcutaneous Tissue, Inflammation | |
Tail, Hyperkeratosis | 1 |
Tail, Inflammation | 2 1 |
Tail, Necrosis | 4 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | |
Hyperplasia, Macrophage | 2 2 4 |
Inflammation, Chronic Active | |
Inflammation | |
Alveolar Epithelium, Hyperplasia | |
Bronchiole, Hyperplasia | 1 |
Interstitium, Infiltration Cellular | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 5| 7| 7| 7| 6| 7| 6| 7| 5| 4| 6| 7| 7| 5| 6| 5| 5| 7| 5| 7|
DAY ON TEST | 3| 3| 3| 8| 3| 5| 3| 3| 3| 0| 3| 4| 3| 5| 5| 1| 3| 3| 9| 1| 9| 6| 3| 1| 3|
| 7| 7| 7| 5| 9| 3| 8| 9| 9| 8| 9| 0| 4| 2| 2| 4| 9| 8| 7| 4| 7| 8| 7| 6| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|
MG/M3 | 4| 5| 6| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 8| 9| 0| 1| 3| 6|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Olfactory Epithelium, Inflammation | 2 |
Respiratory Epithelium, Degeneration | 1 |
Respiratory Epithelium, Inflammation | 2 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 4 |
Nephropathy | 1 1 1 1 1 1|
Pelvis, Dilatation | 2 1 1 1 |
Renal Tubule, Pigmentation | |
__________________________________________________________________________|
Ureter | + |
Dilatation | |
Inflammation | 2 |
__________________________________________________________________________|
Urethra | + + + + +|
Calculus Micro Observation Only | X X X X X|
Inflammation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + M|
Calculus Micro Observation Only | X |
Dilatation | 1 |
Inflammation | 3 |
Transitional Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 2| 7| 6| 5| 6| | |
DAY ON TEST | 3| 3| 3| 6| 0| 3| 3| 4| 1| 1| | |
| 7| 7| 7| 5| 9| 0| 9| 2| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0 | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| | L |
MG/M3 | 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
Hyperkeratosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + M + + + + + | 59 |
Hemorrhage | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + M + M + + I | 54 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + M + + + + + | 58 |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Peyer's Patch, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + M + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | | 2 2.0|
Clear Cell Focus | | 1 2.0|
Congestion | | 1 3.0|
Infarct | | 5 4.0|
Necrosis, Diffuse | 2 3 | 7 2.7|
Centrilobular, Degeneration | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Autolysis | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | | 4 2.5|
Inflammation | | 1 3.0|
Atrium, Thrombosis | X | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + M + + M M | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + | 52 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 2| 7| 6| 5| 6| | |
DAY ON TEST | 3| 3| 3| 6| 0| 3| 3| 4| 1| 1| | |
| 7| 7| 7| 5| 9| 0| 9| 2| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0 | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| | L |
MG/M3 | 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Pars Distalis, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Hyperplasia, Cystic | 1 2 1 1 2 1 1 | 26 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Penis | + | 4 |
Hyperplasia, Squamous | 2 | 4 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + M + + + + + + | 58 |
Atrophy | | 1 2.0|
Ectasia | 2 3 2 2 3 | 44 2.3|
Inflammation | 2 1 4 | 23 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Inflammation | | 3 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Ectasia | | 1 1.0|
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Granuloma Sperm | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Erythroid Cell, Hyperplasia | 2 | 1 2.0|
Myeloid Cell, Hyperplasia | 2 | 17 2.1|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 23 |
Iliac, Hyperplasia, Histiocytic | | 1 2.0|
Iliac, Hyperplasia, Lymphoid | 2 2 | 4 2.8|
Iliac, Hyperplasia, Plasma Cell | 3 | 12 2.9|
Iliac, Pigmentation | | 1 1.0|
Inguinal, Hyperplasia, Lymphoid | 1 1 2 | 8 2.1|
Inguinal, Hyperplasia, Plasma Cell | 3 | 6 1.8|
Inguinal, Inflammation | | 1 1.0|
Inguinal, Pigmentation | | 2 1.0|
Lumbar, Hyperplasia, Plasma Cell | | 1 3.0|
Popliteal, Hyperplasia, Plasma Cell | | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 2| 7| 6| 5| 6| | |
DAY ON TEST | 3| 3| 3| 6| 0| 3| 3| 4| 1| 1| | |
| 7| 7| 7| 5| 9| 0| 9| 2| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0 | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| | L |
MG/M3 | 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Renal, Hyperplasia, Plasma Cell | 4 | 4 3.3|
Renal, Inflammation | | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + M + + I + + | 46 |
Edema | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 2 1.5|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + | 55 |
Hyperplasia, Lymphoid | | 2 2.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 55 |
Congestion | | 2 2.0|
Inflammation | | 5 2.4|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M + I M M + + + | 18 |
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hematopoietic Cell Proliferation | 2 2 2 | 9 2.4|
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Lymphoid | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + I + + + + + + + + | 54 |
Atrophy | 1 2 3 3 2 3 3 | 27 2.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation | | 4 2.3|
Foot, Inflammation | | 1 4.0|
Foot, Necrosis | | 1 1.0|
Prepuce, Hyperplasia, Squamous | | 1 3.0|
Prepuce, Inflammation | | 8 3.4|
Subcutaneous Tissue, Inflammation | | 1 4.0|
Tail, Hyperkeratosis | | 1 1.0|
Tail, Inflammation | 1 | 5 2.0|
Tail, Necrosis | 4 | 11 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Femur, Hyperostosis | 3 | 2 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 2| 7| 6| 5| 6| | |
DAY ON TEST | 3| 3| 3| 6| 0| 3| 3| 4| 1| 1| | |
| 7| 7| 7| 5| 9| 0| 9| 2| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0 | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| | L |
MG/M3 | 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + I + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 2 2.5|
Fibrosis | 3 | 1 3.0|
Hyperplasia, Macrophage | 3 2 | 6 2.8|
Inflammation, Chronic Active | | 1 2.0|
Inflammation | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Bronchiole, Hyperplasia | | 1 1.0|
Interstitium, Infiltration Cellular | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Olfactory Epithelium, Inflammation | | 1 2.0|
Respiratory Epithelium, Degeneration | 1 | 2 1.0|
Respiratory Epithelium, Inflammation | | 2 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Inflammation | 4 | 8 2.9|
Nephropathy | 1 | 9 1.1|
Pelvis, Dilatation | 3 3 2 1 3 2 | 16 2.2|
Renal Tubule, Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Ureter | + | 2 |
Dilatation | 2 | 1 2.0|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Urethra | + + | 10 |
Calculus Micro Observation Only | X X | 10 |
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Calculus Micro Observation Only | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 2| 7| 6| 5| 6| | |
DAY ON TEST | 3| 3| 3| 6| 0| 3| 3| 4| 1| 1| | |
| 7| 7| 7| 5| 9| 0| 9| 2| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0 | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| | L |
MG/M3 | 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Dilatation | | 1 1.0|
Inflammation | 4 | 7 3.9|
Transitional Epithelium, Hyperplasia | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 4| 2| 2| 4| 2| 3| 2| 4| 2| 2| 4| 4| 4| 2| 4| 2| 2| 4| 2| 4| | |
DAY ON TEST | 5| 0| 0| 5| 0| 9| 0| 5| 0| 0| 5| 5| 5| 0| 5| 0| 0| 5| 0| 5| | |
| 8| 6| 6| 8| 6| 5| 6| 8| 6| 6| 8| 8| 8| 6| 8| 6| 6| 8| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 0| 1| 1| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| | L |
LUNG TOX | 6| 3| 9| 3| 5| 7| 1| 3| 7| 3| 0| 2| 3| 2| 4| 5| 4| 7| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + M | 5 |
Hyperkeratosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + I + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + | 6 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 6 |
Hepatocyte, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 6 |
__________________________________________________________________________|____________|
Pharynx | + | 1 |
Hyperkeratosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 6 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 6 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 6 |
Cardiomyopathy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 6 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 6 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + I M | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 6 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 6 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 8 |
Ectasia | 2 2 3 4 3 3 2 2 | 8 2.6|
Inflammation | 4 3 | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + + + I + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 4| 2| 2| 4| 2| 3| 2| 4| 2| 2| 4| 4| 4| 2| 4| 2| 2| 4| 2| 4| | |
DAY ON TEST | 5| 0| 0| 5| 0| 9| 0| 5| 0| 0| 5| 5| 5| 0| 5| 0| 0| 5| 0| 5| | |
| 8| 6| 6| 8| 6| 5| 6| 8| 6| 6| 8| 8| 8| 6| 8| 6| 6| 8| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 0| 1| 1| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| | L |
LUNG TOX | 6| 3| 9| 3| 5| 7| 1| 3| 7| 3| 0| 2| 3| 2| 4| 5| 4| 7| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 6 |
__________________________________________________________________________|____________|
Testes | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 6 |
Myeloid Cell, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Renal, Hyperplasia, Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + + + + M + + + | 9 |
Hyperplasia, Lymphoid | 1 1 | 2 1.0|
Hyperplasia, Macrophage | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M M I M M M | |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 6 |
__________________________________________________________________________|____________|
Thymus | + + + + + I | 5 |
Atrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + M M M | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + | 6 |
Hyperkeratosis | 3 | 1 3.0|
Inflammation | 2 | 1 2.0|
Subcutaneous Tissue, Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | M + + + + + | 5 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + | 11 |
Inflammation, Acute | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 1 1.0|
Interstitium, Inflammation, Focal | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 4| 2| 2| 4| 2| 3| 2| 4| 2| 2| 4| 4| 4| 2| 4| 2| 2| 4| 2| 4| | |
DAY ON TEST | 5| 0| 0| 5| 0| 9| 0| 5| 0| 0| 5| 5| 5| 0| 5| 0| 0| 5| 0| 5| | |
| 8| 6| 6| 8| 6| 5| 6| 8| 6| 6| 8| 8| 8| 6| 8| 6| 6| 8| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 0| 1| 1| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 6| 6| 6| 7| 7| 7| 8| | L |
LUNG TOX | 6| 3| 9| 3| 5| 7| 1| 3| 7| 3| 0| 2| 3| 2| 4| 5| 4| 7| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + | 11 |
Inflammation, Acute | 1 1 | 2 1.0|
Glands, Inflammation | 1 | 1 1.0|
Olfactory Epithelium, Degeneration | 1 1 | 2 1.0|
Respiratory Epithelium, Degeneration | 1 1 | 2 1.0|
Vomeronasal Organ, Infiltration | | |
Cellular, Polymorphonuclear | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 6| 7| 5| 5|
DAY ON TEST | 1| 1| 3| 3| 9| 6| 4| 4| 4| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 2| 8| 9| 2| 1| 1|
| 6| 7| 7| 7| 4| 2| 4| 0| 9| 7| 7| 1| 8| 8| 9| 8| 8| 1| 8| 1| 7| 4| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + M + + +|
Autolysis | 2 4|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + M + + + + +|
Autolysis | 4 |
Anus, Inflammation | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Peyer's Patch, Inflammation | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 2 |
Cyst | |
Fatty Change | |
Infarct | |
Inflammation | 2 |
Necrosis, Diffuse | |
Necrosis | 2 |
Centrilobular, Degeneration | |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Autolysis | 3 |
Inflammation | 3 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + I + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 4 |
Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 6| 7| 5| 5|
DAY ON TEST | 1| 1| 3| 3| 9| 6| 4| 4| 4| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 2| 8| 9| 2| 1| 1|
| 6| 7| 7| 7| 4| 2| 4| 0| 9| 7| 7| 1| 8| 8| 9| 8| 8| 1| 8| 1| 7| 4| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cyst Multilocular | |
Hypertrophy | |
Capsule, Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + M M M + + + M + + M M M + + + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + M + M +|
Pars Distalis, Hyperplasia | 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Cystic | 1 2 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Abdominal, Abscess | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + |
Hyperplasia, Squamous | 1 |
Inflammation | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + I + + + + + + + +|
Cyst | |
Ectasia | 2 2 3 3 3 3 2 2 3 3 2 3 |
Inflammation | 4 2 3 2 3 3 3 3 3 3 3 2 4 4|
Duct, Hyperplasia | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Congestion | |
Inflammation | 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 1 3 1 1 4 2 4|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Iliac, Hyperplasia, Lymphoid | 3 |
Iliac, Hyperplasia, Plasma Cell | 3 3 2 |
Iliac, Inflammation | |
Inguinal, Hyperplasia, Lymphoid | 1 2 1 2 1 2 |
Inguinal, Hyperplasia, Plasma Cell | 2 3 |
Inguinal, Inflammation | 1 |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 6| 7| 5| 5|
DAY ON TEST | 1| 1| 3| 3| 9| 6| 4| 4| 4| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 2| 8| 9| 2| 1| 1|
| 6| 7| 7| 7| 4| 2| 4| 0| 9| 7| 7| 1| 8| 8| 9| 8| 8| 1| 8| 1| 7| 4| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inguinal, Pigmentation | |
Renal, Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M M + + + + I + + + + + + + + M M +|
Congestion | 2 |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + + + + + + + + I + I + + + + + + + + + M|
Hyperplasia, Lymphoid | 1 |
Hyperplasia, Plasma Cell | 2 |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + M + + + + + M + +|
Congestion | 2 2 3 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia, Histiocytic | 2 2|
Hyperplasia, Lymphoid | 1 1 |
Inflammation | 1 1 3 2|
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M + + M M M I + + + + M + + M + M + + M M M M|
Hyperplasia, Histiocytic | 3 1 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hematopoietic Cell Proliferation | 4 3 4 2 4|
Hyperplasia, Lymphoid | 1 |
Inflammation | |
__________________________________________________________________________|
Thymus | + + + + + + + + + I M M + I + A M + + + + + M + +|
Atrophy | 1 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Necrosis | 2 |
Foot, Inflammation | |
Pinna, Inflammation | 4 |
Prepuce, Edema | |
Prepuce, Inflammation | 3 4 4 4 4 4 |
Tail, Inflammation | 4|
Tail, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 6| 7| 5| 5|
DAY ON TEST | 1| 1| 3| 3| 9| 6| 4| 4| 4| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 2| 8| 9| 2| 1| 1|
| 6| 7| 7| 7| 4| 2| 4| 0| 9| 7| 7| 1| 8| 8| 9| 8| 8| 1| 8| 1| 7| 4| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Femur, Osteoporosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Inflammation | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Macrophage | 2 3 1 1 |
Infarct | 1 |
Inflammation, Chronic Active | |
Inflammation | 1 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration | 1 |
Respiratory Epithelium, Degeneration | 1 |
Respiratory Epithelium, Inflammation | 1 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Dilatation | |
Fibrosis | 1|
Inflammation | 3 3 1|
Mineralization | |
Nephropathy | 2 2 |
Cortex, Cyst | 1 |
Pelvis, Dilatation | 2 3 3 2 3 3 3 3 3|
__________________________________________________________________________|
Urethra | + + + |
Calculus Micro Observation Only | X |
Inflammation | 2 1 |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Calculus Micro Observation Only | X |
Inflammation | 4|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 5| 5| 7| 7| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 4| 7| 5| 7| 6| 6| 6| 7| 5| 5|
DAY ON TEST | 1| 1| 3| 3| 9| 6| 4| 4| 4| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 2| 8| 9| 2| 1| 1|
| 6| 7| 7| 7| 4| 2| 4| 0| 9| 7| 7| 1| 8| 8| 9| 8| 8| 1| 8| 1| 7| 4| 0| 6| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.25 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Transitional Epithelium, Metaplasia, | |
Squamous | 3|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 3| 5| 5| 7| 7| 5| 6| 1| 5| 6| 2| 7| 7| 4| 7| 5| 7| 6| 6| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 2| 6| 6| 3| 3| 6| 1| 1| 5| 7| 8| 3| 3| 0| 3| 6| 3| 4| 6| 3|
| 8| 9| 9| 7| 7| 5| 9| 4| 8| 7| 7| 4| 8| 2| 1| 6| 8| 9| 0| 9| 7| 9| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2|
MG/M3 | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 7| 8| 9| 2| 4| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + M + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Large, Rectum | I + + + + + + + + + + + + + + + + + + + + + I + +|
Autolysis | |
Anus, Inflammation | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Peyer's Patch, Inflammation | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2|
Cyst | |
Fatty Change | |
Infarct | |
Inflammation | |
Necrosis, Diffuse | 3 2 1 |
Necrosis | |
Centrilobular, Degeneration | |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + I + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Autolysis | |
Inflammation | |
Acinus, Hyperplasia | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 3| 5| 5| 7| 7| 5| 6| 1| 5| 6| 2| 7| 7| 4| 7| 5| 7| 6| 6| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 2| 6| 6| 3| 3| 6| 1| 1| 5| 7| 8| 3| 3| 0| 3| 6| 3| 4| 6| 3|
| 8| 9| 9| 7| 7| 5| 9| 4| 8| 7| 7| 4| 8| 2| 1| 6| 8| 9| 0| 9| 7| 9| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2|
MG/M3 | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 7| 8| 9| 2| 4| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Cyst Multilocular | |
Hypertrophy | 2 |
Capsule, Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + M + + I + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + M M + M + + M + + + + + + + I +|
__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + M + + + + + + + M + + + +|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia, Cystic | 1 2 1 2 1 2 2 1 2 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Abdominal, Abscess | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + + + |
Hyperplasia, Squamous | 3 |
Inflammation | 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + I + + + + + + + + + + + +|
Cyst | X |
Ectasia | 1 1 2 3 3 1 3 2 3 3 2 2 |
Inflammation | 3 2 3 3 2 3 3 3 2 2 3 2 4 3 4|
Duct, Hyperplasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + M + + + + + + + + + + + +|
Autolysis | |
Congestion | |
Inflammation | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 3 2 2 3 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Iliac, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Plasma Cell | 2 3 3 3 |
Iliac, Inflammation | 1 |
Inguinal, Hyperplasia, Lymphoid | 2 2 |
Inguinal, Hyperplasia, Plasma Cell | 2 2 3 |
Inguinal, Inflammation | 1 |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 3| 5| 5| 7| 7| 5| 6| 1| 5| 6| 2| 7| 7| 4| 7| 5| 7| 6| 6| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 2| 6| 6| 3| 3| 6| 1| 1| 5| 7| 8| 3| 3| 0| 3| 6| 3| 4| 6| 3|
| 8| 9| 9| 7| 7| 5| 9| 4| 8| 7| 7| 4| 8| 2| 1| 6| 8| 9| 0| 9| 7| 9| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2|
MG/M3 | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 7| 8| 9| 2| 4| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inguinal, Pigmentation | |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Bronchial | + M + + + M + + I + + + M + + + I + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Histiocytic | 1 |
Hyperplasia, Lymphoid | 1 2 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + M + + M + + M + + + M + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 1 2 |
Inflammation | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + I + + + + + + + M + + + + + M + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 2 2 |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + I + M M + + M I + + M + M M I + M M M I + + M|
Hyperplasia, Histiocytic | |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hematopoietic Cell Proliferation | 3 2 2 3 2 1 |
Hyperplasia, Lymphoid | 2 2 |
Inflammation | 2 2|
__________________________________________________________________________|
Thymus | + + + M + + + + + + + M + + + + + + + + + M + + +|
Atrophy | 2 2 2 2 2 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 |
Necrosis | |
Foot, Inflammation | |
Pinna, Inflammation | |
Prepuce, Edema | 2 |
Prepuce, Inflammation | 4 4 4 3 4 4 |
Tail, Inflammation | 4 |
Tail, Necrosis | 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | 1 |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 3| 5| 5| 7| 7| 5| 6| 1| 5| 6| 2| 7| 7| 4| 7| 5| 7| 6| 6| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 2| 6| 6| 3| 3| 6| 1| 1| 5| 7| 8| 3| 3| 0| 3| 6| 3| 4| 6| 3|
| 8| 9| 9| 7| 7| 5| 9| 4| 8| 7| 7| 4| 8| 2| 1| 6| 8| 9| 0| 9| 7| 9| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2|
MG/M3 | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 7| 8| 9| 2| 4| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
Femur, Osteoporosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Meninges, Inflammation | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + I + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Macrophage | 1 2 1|
Infarct | |
Inflammation, Chronic Active | 1 1 |
Inflammation | |
Alveolar Epithelium, Hyperplasia | 1 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Degeneration | |
Respiratory Epithelium, Degeneration | |
Respiratory Epithelium, Inflammation | |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Dilatation | |
Fibrosis | |
Inflammation | 4 2 2 2 |
Mineralization | 1 |
Nephropathy | 1 1 2 |
Cortex, Cyst | |
Pelvis, Dilatation | 2 2 2 3 3 3 2 |
__________________________________________________________________________|
Urethra | + + + + + + |
Calculus Micro Observation Only | X X X X |
Inflammation | 2 3 |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +|
Autolysis | |
Calculus Micro Observation Only | X |
Inflammation | 2 2 4 4 |
Transitional Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 3| 5| 5| 7| 7| 5| 6| 1| 5| 6| 2| 7| 7| 4| 7| 5| 7| 6| 6| 7|
DAY ON TEST | 3| 5| 3| 3| 3| 2| 6| 6| 3| 3| 6| 1| 1| 5| 7| 8| 3| 3| 0| 3| 6| 3| 4| 6| 3|
| 8| 9| 9| 7| 7| 5| 9| 4| 8| 7| 7| 4| 8| 2| 1| 6| 8| 9| 0| 9| 7| 9| 1| 3| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.25 | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2|
MG/M3 | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 7| 8| 9| 2| 4| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Transitional Epithelium, Metaplasia, | |
Squamous | |
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 5| 5| 6| 5| 7| 5| 7| | |
DAY ON TEST | 9| 1| 3| 8| 4| 6| 5| 3| 9| 3| | |
| 9| 4| 8| 4| 9| 3| 2| 9| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.25 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
MG/M3 | 3| 4| 5| 6| 8| 0| 2| 4| 6| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 58 |
Autolysis | | 3 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + M + | 56 |
Autolysis | | 1 4.0|
Anus, Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + M | 59 |
Autolysis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 59 |
Autolysis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Autolysis | | 1 4.0|
Peyer's Patch, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
Autolysis | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Basophilic Focus | 3 | 4 2.5|
Cyst | X | 1 |
Fatty Change | 2 | 1 2.0|
Infarct | 4 | 1 4.0|
Inflammation | | 1 2.0|
Necrosis, Diffuse | 3 1 | 5 2.0|
Necrosis | | 1 2.0|
Centrilobular, Degeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Atrophy | | 1 2.0|
Autolysis | | 1 3.0|
Inflammation | | 1 3.0|
Acinus, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + I + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 5| 5| 6| 5| 7| 5| 7| | |
DAY ON TEST | 9| 1| 3| 8| 4| 6| 5| 3| 9| 3| | |
| 9| 4| 8| 4| 9| 3| 2| 9| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.25 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
MG/M3 | 3| 4| 5| 6| 8| 0| 2| 4| 6| 8| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + M | 59 |
Accessory Adrenal Cortical Nodule | | 1 |
Cyst Multilocular | X | 1 |
Hypertrophy | | 1 2.0|
Capsule, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + M | 57 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + M + + M + | 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + | 53 |
Pars Distalis, Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Hyperplasia, Cystic | 2 1 1 2 2 1 | 26 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 2 |
Abdominal, Abscess | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Penis | + | 7 |
Hyperplasia, Squamous | | 2 2.0|
Inflammation | 3 | 2 2.5|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 58 |
Cyst | | 1 |
Ectasia | 2 2 2 2 3 4 2 | 31 2.4|
Inflammation | 3 4 3 3 2 1 | 35 2.9|
Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Autolysis | | 1 3.0|
Congestion | 4 | 1 4.0|
Inflammation | 2 | 3 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Ectasia | | 1 1.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 5| 5| 6| 5| 7| 5| 7| | |
DAY ON TEST | 9| 1| 3| 8| 4| 6| 5| 3| 9| 3| | |
| 9| 4| 8| 4| 9| 3| 2| 9| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.25 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
MG/M3 | 3| 4| 5| 6| 8| 0| 2| 4| 6| 8| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Myeloid Cell, Hyperplasia | 2 2 | 15 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 21 |
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Iliac, Hyperplasia, Plasma Cell | 3 3 2 | 10 2.7|
Iliac, Inflammation | | 1 1.0|
Inguinal, Hyperplasia, Lymphoid | 2 2 3 | 11 1.8|
Inguinal, Hyperplasia, Plasma Cell | | 5 2.4|
Inguinal, Inflammation | | 2 1.0|
Inguinal, Pigmentation | 2 | 1 2.0|
Renal, Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + I + I + + + + | 48 |
Congestion | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia, Histiocytic | | 2 2.0|
Hyperplasia, Lymphoid | 1 | 4 1.5|
Hyperplasia, Plasma Cell | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M M + + + + | 49 |
Hyperplasia, Lymphoid | 1 | 2 1.0|
Hyperplasia, Plasma Cell | | 3 1.7|
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + I + + + + | 53 |
Congestion | 1 | 4 2.0|
Hematopoietic Cell Proliferation | 2 | 2 1.5|
Hyperplasia, Histiocytic | | 2 2.0|
Hyperplasia, Lymphoid | | 4 1.5|
Inflammation | 1 | 5 1.6|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + I M M M I M M + | 24 |
Hyperplasia, Histiocytic | | 2 2.0|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 12 2.6|
Hyperplasia, Lymphoid | | 3 1.7|
Inflammation | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + M M + + + + + + + | 48 |
Atrophy | 1 2 2 2 1 | 14 1.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 5| 5| 6| 5| 7| 5| 7| | |
DAY ON TEST | 9| 1| 3| 8| 4| 6| 5| 3| 9| 3| | |
| 9| 4| 8| 4| 9| 3| 2| 9| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.25 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
MG/M3 | 3| 4| 5| 6| 8| 0| 2| 4| 6| 8| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Inflammation | | 1 4.0|
Necrosis | | 1 2.0|
Foot, Inflammation | 4 | 1 4.0|
Pinna, Inflammation | | 1 4.0|
Prepuce, Edema | | 1 2.0|
Prepuce, Inflammation | 3 3 2 | 15 3.6|
Tail, Inflammation | | 2 4.0|
Tail, Necrosis | 4 4 | 4 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Femur, Hyperostosis | | 1 1.0|
Femur, Osteoporosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Meninges, Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + I + + + + | 58 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hyperplasia, Macrophage | 1 1 | 9 1.4|
Infarct | | 1 1.0|
Inflammation, Chronic Active | | 2 1.0|
Inflammation | 1 | 2 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 4 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Olfactory Epithelium, Degeneration | | 1 1.0|
Respiratory Epithelium, Degeneration | 1 | 2 1.0|
Respiratory Epithelium, Inflammation | | 2 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 5| 5| 6| 5| 7| 5| 7| | |
DAY ON TEST | 9| 1| 3| 8| 4| 6| 5| 3| 9| 3| | |
| 9| 4| 8| 4| 9| 3| 2| 9| 4| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.25 | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
MG/M3 | 3| 4| 5| 6| 8| 0| 2| 4| 6| 8| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Congestion | | 1 2.0|
Dilatation | 4 | 1 4.0|
Fibrosis | | 1 1.0|
Inflammation | | 7 2.4|
Mineralization | | 1 1.0|
Nephropathy | 1 1 1 | 8 1.4|
Cortex, Cyst | X | 2 1.0|
Pelvis, Dilatation | 2 1 3 | 19 2.5|
__________________________________________________________________________|____________|
Urethra | + + + | 12 |
Calculus Micro Observation Only | X X | 7 |
Inflammation | | 4 2.0|
Transitional Epithelium, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Autolysis | | 1 3.0|
Calculus Micro Observation Only | | 2 |
Inflammation | 4 | 6 3.3|
Transitional Epithelium, Hyperplasia | | 1 1.0|
Transitional Epithelium, Metaplasia, | | |
Squamous | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 2| 2| 4| 2| 4| 2| 4| 4| 2| 1| 2| 2| 2| 4| 4| 4| 2| 4| 4| 4| | |
DAY ON TEST | 0| 0| 5| 0| 5| 0| 5| 5| 0| 2| 0| 0| 0| 5| 5| 5| 0| 5| 5| 5| | |
| 6| 6| 8| 6| 8| 6| 8| 8| 6| 2| 6| 6| 6| 8| 8| 8| 6| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.25MG/M3 | 7| 7| 8| 8| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| | L |
LUNG TOX | 0| 1| 7| 9| 3| 4| 6| 0| 1| 3| 5| 1| 7| 9| 1| 3| 5| 7| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 6 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + I + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + M + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + M + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + M + | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + + + | 7 |
Infarct, Focal | 2 | 1 2.0|
Hepatocyte, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 6 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 6 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + I | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 6 |
Autolysis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 6 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + I + + + | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 6 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + I | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | I + + + I + | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 6 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 6 |
Ectasia | 3 2 1 2 4 | 5 2.4|
Inflammation | 3 4 | 2 3.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 6 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 6 |
__________________________________________________________________________|____________|
Testes | + + + + + + | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 2| 2| 4| 2| 4| 2| 4| 4| 2| 1| 2| 2| 2| 4| 4| 4| 2| 4| 4| 4| | |
DAY ON TEST | 0| 0| 5| 0| 5| 0| 5| 5| 0| 2| 0| 0| 0| 5| 5| 5| 0| 5| 5| 5| | |
| 6| 6| 8| 6| 8| 6| 8| 8| 6| 2| 6| 6| 6| 8| 8| 8| 6| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.25MG/M3 | 7| 7| 8| 8| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| | L |
LUNG TOX | 0| 1| 7| 9| 3| 4| 6| 0| 1| 3| 5| 1| 7| 9| 1| 3| 5| 7| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 6 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Iliac, Hyperplasia, Lymphoid | 3 | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + + I + + + + + | 9 |
Hyperplasia, Lymphoid | 2 1 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 6 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + + M M + M + | 7 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 6 |
__________________________________________________________________________|____________|
Thymus | + + + + + + | 6 |
Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + M M | 3 |
__________________________________________________________________________|____________|
Skin | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 6 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + | 11 |
Hyperplasia, Macrophage | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + | 11 |
Developmental Malformation | X | 1 |
Inflammation, Acute | 1 1 | 2 1.0|
Vomeronasal Organ, Infiltration | | |
Cellular, Polymorphonuclear | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 2| 2| 4| 2| 4| 2| 4| 4| 2| 1| 2| 2| 2| 4| 4| 4| 2| 4| 4| 4| | |
DAY ON TEST | 0| 0| 5| 0| 5| 0| 5| 5| 0| 2| 0| 0| 0| 5| 5| 5| 0| 5| 5| 5| | |
| 6| 6| 8| 6| 8| 6| 8| 8| 6| 2| 6| 6| 6| 8| 8| 8| 6| 8| 8| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
.25MG/M3 | 7| 7| 8| 8| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| | L |
LUNG TOX | 0| 1| 7| 9| 3| 4| 6| 0| 1| 3| 5| 1| 7| 9| 1| 3| 5| 7| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + | 11 |
__________________________________________________________________________|____________|
Urethra | + | 1 |
Calculus Micro Observation Only | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 5| 6| 6| 4| 7| 7| 5| 7| 5| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 1| 4| 5| 9| 2| 1| 0| 3| 9| 3| 6| 3| 3| 3| 3| 4| 1| 3| 9| 3| 3| 6| 3|
| 7| 9| 0| 2| 3| 6| 1| 9| 5| 9| 4| 7| 4| 7| 8| 9| 9| 0| 3| 7| 1| 8| 8| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Gallbladder | + + + + + + + A + + + + + + + + + + + I + I + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Intestine Large, Rectum | I + M + + + + A + + + + + + + + I + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + M + + + + A + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + M + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + M + + + + A + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | M + M + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | |
Autolysis | 4 1 |
Basophilic Focus | |
Congestion | 4 |
Eosinophilic Focus | 3 |
Infarct | 4 |
Inflammation | 1 |
Necrosis, Diffuse | 3 3 |
Necrosis | |
Pigmentation | 3 |
__________________________________________________________________________|
Mesentery | |
Inflammation | |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Inflammation | 3 |
__________________________________________________________________________|
Tooth | + + +|
Peridontal Tissue, Inflammation | 2 2 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
_____________________________________________________________________________________________________________________|
Page 98
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 5| 6| 6| 4| 7| 7| 5| 7| 5| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 1| 4| 5| 9| 2| 1| 0| 3| 9| 3| 6| 3| 3| 3| 3| 4| 1| 3| 9| 3| 3| 6| 3|
| 7| 9| 0| 2| 3| 6| 1| 9| 5| 9| 4| 7| 4| 7| 8| 9| 9| 0| 3| 7| 1| 8| 8| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hypertrophy | 1 |
Infarct | 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + A + + + I + + + + + + + + + + + + +|
Infarct | 4 |
__________________________________________________________________________|
Islets, Pancreatic | + + M + + + + A M + + + + + + + + + + I + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + M + + M + + + + + + + I + + + I + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + + + + + + M + + + +|
Autolysis | 2 |
Cyst | X |
__________________________________________________________________________|
Thyroid Gland | + + I + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Follicular Cell, Hyperplasia, Cystic | 2 2 1 2 1 2 1 2 1 1 1 2 2 2|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Penis | + + + |
Hyperplasia, Squamous | 1 3 |
Inflammation | 2 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + A + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | 3 2 2 3 2 2 2 2 2 3 1 |
Inflammation | 4 3 4 4 4 2 3 2 2 3 2 3 4 3 3 3 3|
__________________________________________________________________________|
Prostate | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation | 2 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + A + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hyperplasia | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Autolysis | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + A + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 1 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Iliac, Hyperplasia, Lymphoid | 1 |
_____________________________________________________________________________________________________________________|
Page 99
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 5| 6| 6| 4| 7| 7| 5| 7| 5| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 1| 4| 5| 9| 2| 1| 0| 3| 9| 3| 6| 3| 3| 3| 3| 4| 1| 3| 9| 3| 3| 6| 3|
| 7| 9| 0| 2| 3| 6| 1| 9| 5| 9| 4| 7| 4| 7| 8| 9| 9| 0| 3| 7| 1| 8| 8| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Hyperplasia, Plasma Cell | 1 3 3 |
Inguinal, Hyperplasia, Histiocytic | 1 |
Inguinal, Hyperplasia, Lymphoid | 2 3 2|
Inguinal, Hyperplasia, Plasma Cell | 2 1 |
Inguinal, Inflammation | |
Lumbar, Hyperplasia, Plasma Cell | |
Pancreatic, Thrombosis | 1 |
Renal, Congestion | |
Renal, Hyperplasia, Histiocytic | 2 |
Renal, Hyperplasia, Plasma Cell | 2 |
Renal, Inflammation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M I M M + A + + I + + + + + + + + + + + + I +|
Congestion | |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Macrophage | 1 1 1 1 1 1 1 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + M + + + M + + + + + + + + + + M + +|
Ectasia | |
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M M + + + A + + + + + + + + + + + + + + + + +|
Angiectasis | 3 1 |
Congestion | |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M + M + I A M M M M I + M M I M + M + + + + M|
__________________________________________________________________________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hematopoietic Cell Proliferation | 3 1 2 1 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Thymus | + + + + + + + A + + + + + + + + + M + + + + + + M|
Atrophy | 2 3 4 4 2 1 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 |
Inflammation, Chronic | 3 |
Inflammation | 3 2 |
Foot, Inflammation | |
Prepuce, Inflammation | 4 2 3 3 4 2 3 4 4 4 |
Tail, Hyperkeratosis | 2 |
Tail, Inflammation | 2 |
Tail, Necrosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 100
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 5| 6| 6| 4| 7| 7| 5| 7| 5| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 1| 4| 5| 9| 2| 1| 0| 3| 9| 3| 6| 3| 3| 3| 3| 4| 1| 3| 9| 3| 3| 6| 3|
| 7| 9| 0| 2| 3| 6| 1| 9| 5| 9| 4| 7| 4| 7| 8| 9| 9| 0| 3| 7| 1| 8| 8| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | 2 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Degeneration | 2 |
Hippocampus, Degeneration | 1 |
Thalamus, Degeneration | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + A + + + + + + I + + + + + + + M + +|
Autolysis | 3 |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Fibrosis | 2 |
Hemorrhage | 1 |
Hyperplasia, Macrophage | 1 1 1 1 1 1 2 2 1 2 1 1 4 2 1 2 2 2|
Inflammation, Chronic Active | 2 1 2 1 1 2|
Alveolar Epithelium, Hyperplasia | 2 1 1 1 1 1 1 1|
Interstitium, Infiltration Cellular | 2 1 1|
__________________________________________________________________________|
Nose | + + + + + + + A + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy | 1 1 1|
Respiratory Epithelium, Inflammation | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + A + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Phthisis Bulbi | X |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + A + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Inflammation | 4 1 3 1 |
Nephropathy | 1 1 1 1 1 |
Cortex, Cyst | X |
Pelvis, Dilatation | 1 2 |
__________________________________________________________________________|
Ureter | + |
Inflammation | 4 |
__________________________________________________________________________|
Urethra | + + + + + + + + |
Calculus Micro Observation Only | X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 101
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 7| 7| 3| 6| 5| 6| 6| 4| 7| 7| 5| 7| 5| 7| 7| 7| 7| 6| 6| 7| 5| 7| 7| 5| 7|
DAY ON TEST | 3| 3| 1| 4| 5| 9| 2| 1| 0| 3| 9| 3| 6| 3| 3| 3| 3| 4| 1| 3| 9| 3| 3| 6| 3|
| 7| 9| 0| 2| 3| 6| 1| 9| 5| 9| 4| 7| 4| 7| 8| 9| 9| 0| 3| 7| 1| 8| 8| 4| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation | 2 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Inflammation | 4 4 4 4 |
Transitional Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 5| 7| 7| 5| 6| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 6| 3| 6| 7| 6| 6| 2| 7| 2|
DAY ON TEST | 5| 2| 3| 7| 1| 8| 3| 1| 1| 3| 3| 3| 3| 8| 3| 3| 4| 3| 4| 3| 3| 2| 8| 3| 4|
| 2| 8| 7| 8| 4| 5| 9| 3| 1| 9| 8| 8| 8| 1| 7| 8| 8| 7| 2| 9| 9| 7| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MG/M3 | 2| 3| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Gallbladder | + + + + + + + M + + M + + M + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + I + + + + + I + + + I + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Autolysis | |
Basophilic Focus | 2 |
Congestion | |
Eosinophilic Focus | |
Infarct | |
Inflammation | |
Necrosis, Diffuse | 1 2 2 |
Necrosis | 2 |
Pigmentation | |
__________________________________________________________________________|
Mesentery | |
Inflammation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + I|
Cyst | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 1 |
Inflammation | |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 3 |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 5| 7| 7| 5| 6| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 6| 3| 6| 7| 6| 6| 2| 7| 2|
DAY ON TEST | 5| 2| 3| 7| 1| 8| 3| 1| 1| 3| 3| 3| 3| 8| 3| 3| 4| 3| 4| 3| 3| 2| 8| 3| 4|
| 2| 8| 7| 8| 4| 5| 9| 3| 1| 9| 8| 8| 8| 1| 7| 8| 8| 7| 2| 9| 9| 7| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MG/M3 | 2| 3| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hypertrophy | |
Infarct | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + M + + +|
Infarct | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M I + M + + + + + M + + M + + + +|
Autolysis | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Autolysis | |
Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Follicular Cell, Hyperplasia, Cystic | 2 2 1 2 2 1 2 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Penis | + + + + |
Hyperplasia, Squamous | 3 3 |
Inflammation | 4 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Atrophy | 2 |
Ectasia | 1 3 2 2 3 2 4 2 3 3 4 4 3 3 |
Inflammation | 2 4 2 4 4 3 3 4 3 4 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Autolysis | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | 2 2 2 3 4|
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Iliac, Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 5| 7| 7| 5| 6| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 6| 3| 6| 7| 6| 6| 2| 7| 2|
DAY ON TEST | 5| 2| 3| 7| 1| 8| 3| 1| 1| 3| 3| 3| 3| 8| 3| 3| 4| 3| 4| 3| 3| 2| 8| 3| 4|
| 2| 8| 7| 8| 4| 5| 9| 3| 1| 9| 8| 8| 8| 1| 7| 8| 8| 7| 2| 9| 9| 7| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MG/M3 | 2| 3| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Iliac, Hyperplasia, Plasma Cell | 2 2 3 3 |
Inguinal, Hyperplasia, Histiocytic | 1|
Inguinal, Hyperplasia, Lymphoid | 2 |
Inguinal, Hyperplasia, Plasma Cell | 1 3 |
Inguinal, Inflammation | 1 |
Lumbar, Hyperplasia, Plasma Cell | 3 |
Pancreatic, Thrombosis | |
Renal, Congestion | 2 |
Renal, Hyperplasia, Histiocytic | |
Renal, Hyperplasia, Plasma Cell | |
Renal, Inflammation | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + M I + + + + + + + + + + + + M + I + M|
Congestion | 2 |
Hyperplasia, Lymphoid | 1 |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + + + + + + +|
Ectasia | 2 |
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + A + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Congestion | 2 |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M I M M M M M + I M M M M + M + M M M M + M M + M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hematopoietic Cell Proliferation | 2 2 1 2 3|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Thymus | M + M + + + + + + M + + + + + + + + + + + + + + M|
Atrophy | 3 1 3 1 2 1 1 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Inflammation, Chronic | |
Inflammation | 2 2 |
Foot, Inflammation | 4 |
Prepuce, Inflammation | 3 3 3 4 3 |
Tail, Hyperkeratosis | |
Tail, Inflammation | |
Tail, Necrosis | 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 5| 7| 7| 5| 6| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 6| 3| 6| 7| 6| 6| 2| 7| 2|
DAY ON TEST | 5| 2| 3| 7| 1| 8| 3| 1| 1| 3| 3| 3| 3| 8| 3| 3| 4| 3| 4| 3| 3| 2| 8| 3| 4|
| 2| 8| 7| 8| 4| 5| 9| 3| 1| 9| 8| 8| 8| 1| 7| 8| 8| 7| 2| 9| 9| 7| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MG/M3 | 2| 3| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Degeneration | |
Hippocampus, Degeneration | |
Thalamus, Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Squamous | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Fibrosis | |
Hemorrhage | |
Hyperplasia, Macrophage | 2 1 1 2 2 1 1 2 3 2 1 1 1 1 |
Inflammation, Chronic Active | 2 1 |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 |
Interstitium, Infiltration Cellular | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy | 1 1 1 1 1 1 |
Respiratory Epithelium, Inflammation | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Phthisis Bulbi | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 4 4|
Inflammation | 3 2 4|
Nephropathy | 1 1 1 |
Cortex, Cyst | |
Pelvis, Dilatation | 3 2 1 4 2 |
__________________________________________________________________________|
Ureter | |
Inflammation | |
__________________________________________________________________________|
Urethra | + + + |
Calculus Micro Observation Only | X X X |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
_____________________________________________________________________________________________________________________
| 5| 7| 7| 5| 6| 4| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 6| 3| 6| 7| 6| 6| 2| 7| 2|
DAY ON TEST | 5| 2| 3| 7| 1| 8| 3| 1| 1| 3| 3| 3| 3| 8| 3| 3| 4| 3| 4| 3| 3| 2| 8| 3| 4|
| 2| 8| 7| 8| 4| 5| 9| 3| 1| 9| 8| 8| 8| 1| 7| 8| 8| 7| 2| 9| 9| 7| 4| 7| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.5 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|
MG/M3 | 2| 3| 5| 6| 7| 8| 9| 1| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Inflammation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + M + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Inflammation | 2 3 3|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 5| 6| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 7| 8| 3| 2| 1| 0| 9| 1| | |
| 9| 8| 2| 2| 8| 9| 7| 2| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
MG/M3 | 6| 7| 8| 9| 1| 3| 4| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
Hyperkeratosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 54 |
Autolysis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + I M + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
Autolysis | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 57 |
Peyer's Patch, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis, Focal | | 1 2.0|
Autolysis | | 2 2.5|
Basophilic Focus | | 1 2.0|
Congestion | | 1 4.0|
Eosinophilic Focus | | 1 3.0|
Infarct | | 1 4.0|
Inflammation | | 1 1.0|
Necrosis, Diffuse | 2 1 | 7 2.0|
Necrosis | | 1 2.0|
Pigmentation | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Autolysis | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperplasia, Squamous | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Autolysis | | 2 2.0|
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 4 |
Peridontal Tissue, Inflammation | | 4 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 5| 6| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 7| 8| 3| 2| 1| 0| 9| 1| | |
| 9| 8| 2| 2| 8| 9| 7| 2| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
MG/M3 | 6| 7| 8| 9| 1| 3| 4| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Hyperplasia | | 3 2.0|
Hypertrophy | | 1 1.0|
Infarct | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 57 |
Infarct | | 1 4.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 55 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + M + + | 49 |
Autolysis | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + | 56 |
Autolysis | | 1 2.0|
Cyst | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Autolysis | | 1 3.0|
Follicular Cell, Hyperplasia, Cystic | 1 1 3 | 25 1.6|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Autolysis | | 1 3.0|
__________________________________________________________________________|____________|
Penis | + I + | 9 |
Hyperplasia, Squamous | 4 2 | 6 2.7|
Inflammation | | 3 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 58 |
Atrophy | 1 | 2 1.5|
Ectasia | 3 2 2 2 2 2 | 31 2.5|
Inflammation | 3 3 3 3 | 33 3.1|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
Hyperplasia | | 1 3.0|
Inflammation | | 3 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
Ectasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 109
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 5| 6| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 7| 8| 3| 2| 1| 0| 9| 1| | |
| 9| 8| 2| 2| 8| 9| 7| 2| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.5 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| | L |
MG/M3 | 6| 7| 8| 9| 1| 3| 4| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Atrophy | | 1 1.0|
Autolysis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Myeloid Cell, Hyperplasia | 2 2 | 11 2.2|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 20 |
Iliac, Hyperplasia, Lymphoid | 2 3 | 4 2.0|
Iliac, Hyperplasia, Plasma Cell | | 7 2.4|
Inguinal, Hyperplasia, Histiocytic | | 2 1.0|
Inguinal, Hyperplasia, Lymphoid | 3 2 2 | 7 2.3|
Inguinal, Hyperplasia, Plasma Cell | | 4 1.8|
Inguinal, Inflammation | | 1 1.0|
Lumbar, Hyperplasia, Plasma Cell | | 1 3.0|
Pancreatic, Thrombosis | | 1 1.0|
Renal, Congestion | | 1 2.0|
Renal, Hyperplasia, Histiocytic | | 1 2.0|
Renal, Hyperplasia, Plasma Cell | | 1 2.0|
Renal, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M M + + + M + M | 44 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | | 2 2.0|
Hyperplasia, Macrophage | | 8 1.1|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 55 |
Ectasia | | 1 2.0|
Hyperplasia, Lymphoid | 2 1 | 4 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + + + | 55 |
Angiectasis | | 2 2.0|
Congestion | | 1 2.0|
Hyperplasia, Histiocytic | 1 1 | 2 1.0|
Hyperplasia, Lymphoid | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + + + M M M | 20 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Autolysis | | 1 3.0|
Hematopoietic Cell Proliferation | 1 1 | 11 1.7|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + M + M + + + + + + | 51 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 110
NTP Experiment-Test: 05122-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:11:37
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 4| 5| 6| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 7| 8| 3| 2| 1| 0| 9| 1| | |
| 9| 8| 2| 2| 8| 9| 7| 2| 9| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0|