TDMS Study 05122-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: LITRI NICKEL SULFATE HEXAHYDRATE DATE: 05/20/95
EXPERIMENT: 05122 TEST: 06 TIME: 04:07:32
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: Y01ES30108 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C60344
PATHOLOGIST: F. HAHN CAS: 010101970
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: LITRI NICKEL SULFATE HEXAHYDRATE DATE: 05/20/95
EXPERIMENT: 05122 TEST: 06 TIME: 04:07:32
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: Y01ES30108 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C60344
PATHOLOGIST: F. HAHN CAS: 010101970
NICKEL SULFATE HEXAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 34 CENSORED DEATHS 0 TERMINAL 26 |
| |
| UNCENSORED DEATHS |
| 230 287 452 514 516 516 552 553 555 568 |
| 570 570 573 580 585 597 597 598 601 607 |
| 608 609 614 614 616 627 640 642 642 665 |
| 676 687 688 734 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.0MG/M3LUNG TOX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 1 CENSORED DEATHS 19 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 395 |
| CENSORED DEATHS |
| 206 206 206 206 206 206 206 206 206 206 |
| 458 458 458 458 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.25 MG/M3 |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 37 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 118 286 325 400 438 510 516 516 517 549 |
| 552 552 559 562 564 567 567 569 581 584 |
| 594 594 614 621 640 641 644 649 663 663 |
| 671 687 694 699 714 720 721 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NICKEL SULFATE HEXAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = .25MG/M3LUNG TOX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 1 CENSORED DEATHS 19 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 122 |
| CENSORED DEATHS |
| 206 206 206 206 206 206 206 206 206 458 |
| 458 458 458 458 458 458 458 458 458 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5 MG/M3 |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 36 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 245 284 310 337 419 482 485 511 513 538 |
| 552 553 564 564 578 581 591 594 613 613 |
| 614 621 627 629 639 640 642 642 648 672 |
| 696 699 702 705 717 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5MG/M3LUNG TOX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 2 CENSORED DEATHS 18 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 384 455 |
| CENSORED DEATHS |
| 206 206 206 206 206 206 206 206 206 206 |
| 458 458 458 458 458 458 458 458 |
| |
==================================================================================
NICKEL SULFATE HEXAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 35 CENSORED DEATHS 0 TERMINAL 25 |
| |
| UNCENSORED DEATHS |
| 169 328 394 404 503 529 533 533 561 568 |
| 570 572 594 597 597 601 603 604 610 621 |
| 630 638 640 641 641 657 675 675 676 676 |
| 679 699 699 709 720 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0MG/M3LUNG TOX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 2 CENSORED DEATHS 18 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 447 458 |
| CENSORED DEATHS |
| 206 206 206 206 206 206 206 206 206 206 |
| 458 458 458 458 458 458 458 458 |
| |
==================================================================================
NICKEL SULFATE HEXAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 737 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0 | 100.0 100.0 98.3 96.7 96.7 95.0 90.0 68.3 50.0 43.3 |
|MG/M3 | |
| | |
|0.0MG/M3LUN| 100.0 100.0 100.0 100.0 90.0 0.0 0.0 0.0 0.0 0.0 |
|TOX | |
| | |
|0.25 | 100.0 98.3 98.3 95.0 93.3 91.7 85.0 63.3 50.0 38.3 |
|MG/M3 | |
| | |
|.25MG/M3LUN| 100.0 95.0 95.0 95.0 95.0 0.0 0.0 0.0 0.0 0.0 |
|TOX | |
| | |
|0.5 | 100.0 100.0 98.3 93.3 91.7 88.3 83.3 70.0 51.7 40.0 |
|MG/M3 | |
| | |
|0.5MG/M3LUN| 100.0 100.0 100.0 100.0 90.0 0.0 0.0 0.0 0.0 0.0 |
|TOX | |
| | |
|1.0 | 100.0 98.3 98.3 96.7 93.3 93.3 86.7 70.0 56.7 41.7 |
|MG/M3 | |
| | |
|1.0MG/M3LUN| 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 0.0 |
|TOX | |
| | |
==================================================================================
NICKEL SULFATE HEXAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 737 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0 0.0MG/M3LUNG0.25 .25MG/M3LUNG0.5 0.5MG/M3LUNG1.0 1.0MG/M3L|NG
| MG/M3 TOX MG/M3 TOX MG/M3 TOX MG/M3 TOX |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 43.3% 0.0% 38.3% 0.0% 40.0% 0.0% 41.7% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000N ----- P=0.657 P=1.000 P=0.877 P=0.307 P=1.000N P=0.307 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 578.9 395.0 569.2 122.0 570.8 419.5 587.0 452.5 |
|NATURAL DEATHS (C) | (17.0) ( . ) (20.7) ( . ) (20.4) (35.5) (19.4) ( 5.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 647.4 328.9 633.5 327.8 637.3 328.2 649.5 331.5 |
|(STANDARD ERROR) | (14.0) (28.4) (16.6) (30.1) (16.1) (28.3) (14.8) (28.8) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NICKEL SULFATE HEXAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 258 335 384 398 440 530 547 585 595 598 |
| 626 627 627 629 654 655 670 696 700 705 |
| 707 714 714 723 725 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.0MG/M3LUNG TOX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 1 CENSORED DEATHS 19 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| 35 |
| CENSORED DEATHS |
| 207 207 207 207 207 207 207 207 207 459 |
| 459 459 459 459 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.25 MG/M3 |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 14 361 375 398 483 511 559 578 588 614 |
| 624 635 649 666 672 679 687 703 711 725 |
| 728 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
NICKEL SULFATE HEXAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = .25MG/M3LUNG TOX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 0 CENSORED DEATHS 20 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 207 207 207 207 207 207 207 207 207 207 |
| 459 459 459 459 459 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5 MG/M3 |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 334 454 510 539 567 577 614 629 649 656 |
| 672 672 681 681 714 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.5MG/M3LUNG TOX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 0 CENSORED DEATHS 20 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 207 207 207 207 207 207 207 207 207 207 |
| 459 459 459 459 459 459 459 459 459 459 |
| |
==================================================================================
NICKEL SULFATE HEXAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1.0 MG/M3 |
| ---------------------------- |
| |
| TOTAL 60 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 281 310 361 370 393 457 463 516 521 562 |
| 562 571 596 601 604 659 669 675 679 698 |
| 713 714 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0MG/M3LUNG TOX |
| ---------------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 0 CENSORED DEATHS 20 TERMINAL 0 |
| |
| UNCENSORED DEATHS |
| NONE |
| CENSORED DEATHS |
| 207 207 207 207 207 207 207 207 207 207 |
| 459 459 459 459 459 459 459 459 459 459 |
| |
==================================================================================
NICKEL SULFATE HEXAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 730 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0.0 | 100.0 100.0 98.3 96.7 93.3 91.7 90.0 83.3 73.3 56.7 |
|MG/M3 | |
| | |
|0.0MG/M3LUN| 95.0 95.0 95.0 95.0 95.0 0.0 0.0 0.0 0.0 0.0 |
|TOX | |
| | |
|0.25 | 98.3 98.3 98.3 96.7 93.3 91.7 90.0 85.0 78.3 65.0 |
|MG/M3 | |
| | |
|.25MG/M3LUN| 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 0.0 |
|TOX | |
| | |
|0.5 | 100.0 100.0 100.0 98.3 98.3 96.7 93.3 90.0 83.3 75.0 |
|MG/M3 | |
| | |
|0.5MG/M3LUN| 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 0.0 |
|TOX | |
| | |
|1.0 | 100.0 100.0 100.0 95.0 91.7 88.3 85.0 75.0 73.3 61.7 |
|MG/M3 | |
| | |
|1.0MG/M3LUN| 100.0 100.0 100.0 100.0 100.0 0.0 0.0 0.0 0.0 0.0 |
|TOX | |
| | |
==================================================================================
NICKEL SULFATE HEXAHYDRATE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 730 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0.0 0.0MG/M3LUNG0.25 .25MG/M3LUNG0.5 0.5MG/M3LUNG1.0 1.0MG/M3L|NG
| MG/M3 TOX MG/M3 TOX MG/M3 TOX MG/M3 TOX |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 56.7% 0.0% 65.0% 0.0% 75.0% 0.0% 61.7% 0.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.693N ----- P=0.494N P=0.766N P=0.062N P=0.766N P=0.843N P=0.766N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 598.8 35.0 569.5 . 596.6 . 552.3 . |
|NATURAL DEATHS (C) | (25.9) ( . ) (37.1) ( . ) (26.6) ( . ) (28.6) ( . ) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 673.2 324.4 673.8 333.0 696.7 333.0 661.9 333.0 |
|(STANDARD ERROR) | (14.0) (32.0) (16.2) (28.9) ( 9.9) (28.9) (15.6) (28.9) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
NICKEL SULFATE HEXAHYDRATE
KAPLAN-MEIER SURVIVAL CURVES
0.0 MG/M3 = 1
0.0MG/M3LUNG TOX = 2
0.25 MG/M3 = 3
.25MG/M3LUNG TOX = 4
0.5 MG/M3 = 5
0.5MG/M3LUNG TOX = 6
1.0 MG/M3 = 7
1.0MG/M3LUNG TOX = 8
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 34 7 1 5 1 7 6 2 8
| 4 1 5 3 5 73 5 3 1 4 7 1
P | 6 2 5 38 68 25 731 77 1
E | 53 5 1171
R 80 + 68 6 33311 77
C | 5 11 517
E | 3333 51157
N | 3 3 1155 7
T 60 + 131 3 7
| 1 137 3 7
S | 15 131 15
U | 13535 11
R 40 + 335 3
V |
I |
V |
A 20 +
L |
|
|
0 + 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 98 obs hidden.
NICKEL SULFATE HEXAHYDRATE
KAPLAN-MEIER SURVIVAL CURVES
0.0 MG/M3 = 1
0.0MG/M3LUNG TOX = 2
0.25 MG/M3 = 3
.25MG/M3LUNG TOX = 4
0.5 MG/M3 = 5
0.5MG/M3LUNG TOX = 6
1.0 MG/M3 = 7
1.0MG/M3LUNG TOX = 8
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 1 7 7 1 3 5 4
| 2 7 1 373 1 1 1 5 2 3 5 5 5
P | 7 1 77 3 37 1 135 31 5 5
E | 7 7 7 31 11 3 1 55 5
R 80 + 77 7 33 3 3 5
C | 77 1 1 71353 5 5
E | 17 3113 3
N | 711 3 3
T 60 + 1 1 7
| 1 1
S |
U |
R 40 +
V |
I |
V |
A 20 +
L |
|
|
0 + 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 69 obs hidden.