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https://ntp.niehs.nih.gov/go/3714

TDMS Study 05122-05 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                     NICKEL SULFATE HEXAHYDRATE


NTP Experiment-Test: 05122-05                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  010101970

       Lock Date:  02/03/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          58           12           58           12           59           11           
  Scheduled Sacrifice                                  5           12            5           12            5           11           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                27                        32                        22                        
    Natural Death                                      4                         4                         3                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                22                        17                        28                        
  Other                                                                                                    1                        
  Animals Examined Microscopically                    58            5           58            5           58            5           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (57)                      (55)                      (58)                      
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Intestine Large, Rectum                            (56)                      (56)                      (53)                      
      Parasite Metazoan                                2 (4%)                    1 (2%)                    1 (2%)                   
   Intestine Large, Cecum                             (56)                      (58)                      (58)                      
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Ulcer                                                                      1 (2%)                                             
   Intestine Small, Duodenum                          (56)                      (58)                      (57)                      
      Ulcer                                            1 (2%)                                                                       
   Intestine Small, Jejunum                           (57)                      (58)                      (58)                      
      Autolysis                                                                                            1 (2%)                   
      Peyer's Patch, Hyperplasia                       2 (4%)                    1 (2%)                    3 (5%)                   
   Intestine Small, Ileum                             (54)                      (56)                      (57)                      
      Autolysis                                                                                            1 (2%)                   
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)                                                                       
   Liver                                              (57)                      (58)                      (58)                      
      Angiectasis                                      3 (5%)                    4 (7%)                    2 (3%)                   
      Basophilic Focus                                49 (86%)                  46 (79%)                  45 (78%)                  
      Clear Cell Focus                                 4 (7%)                    1 (2%)                    2 (3%)                   
      Degeneration, Cystic                             4 (7%)                    5 (9%)                    5 (9%)                   
      Degeneration, Fatty                             15 (26%)                  13 (22%)                  14 (24%)                  
      Eosinophilic Focus                               2 (4%)                    4 (7%)                    2 (3%)                   
      Granuloma                                                                                            2 (3%)                   
      Hepatodiaphragmatic Nodule                       5 (9%)                    5 (9%)                    6 (10%)                  
      Inflammation                                     4 (7%)                                                                       
      Mixed Cell Focus                                 4 (7%)                    1 (2%)                    1 (2%)                   
      Thrombosis, Multiple                             1 (2%)                                                                       
      Bile Duct, Hyperplasia                          10 (18%)                  11 (19%)                  16 (28%)                  
      Centrilobular, Atrophy                           2 (4%)                    5 (9%)                    7 (12%)                  
      Hepatocyte, Necrosis                            13 (23%)                  11 (19%)                   3 (5%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (1)                       (2)                       (2)                       
      Hemorrhage                                                                 1 (50%)                                            
   Pancreas                                           (57)                      (58)                      (58)                      
      Infiltration Cellular, Lymphocyte                                                                    1 (2%)                   
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Acinus, Atrophy                                                            1 (2%)                    4 (7%)                   
   Salivary Glands                                    (57)                      (58)                      (58)                      
      Duct, Submandibular Gland, Hyperplasia                                     1 (2%)                                             
   Stomach, Forestomach                               (57)                      (58)                      (58)                      
      Edema                                                                      1 (2%)                                             
      Hyperkeratosis                                   1 (2%)                                                                       
      Hyperplasia                                                                                          1 (2%)                   
      Inflammation                                                               1 (2%)                    1 (2%)                   
      Ulcer                                                                                                1 (2%)                   
   Stomach, Glandular                                 (57)                      (58)                      (58)                      
      Erosion                                          1 (2%)                    1 (2%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation                                     1 (2%)                                              1 (2%)                   
   Tongue                                                                       (1)                                                 
      Inflammation                                                               1 (100%)                                           
   Tooth                                              (3)                       (5)                                                 
      Epithelium Alveolus, Hyperplasia, Squamous                                 1 (20%)                                            
      Peridontal Tissue, Inflammation                  3 (100%)                  5 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (58)                      (58)                      (58)                      
      Cardiomyopathy                                  12 (21%)                   9 (16%)                   8 (14%)                  
      Thrombosis                                       1 (2%)                    1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (57)                      (58)                      (58)                      
      Autolysis                                        1 (2%)                                                                       
      Congestion                                       2 (4%)                                                                       
      Cyst                                             2 (4%)                                                                       
      Degeneration                                     1 (2%)                                                                       
      Hemorrhage                                                                                           1 (2%)                   
      Hyperplasia                                      7 (12%)                   6 (10%)                   5 (9%)                   
      Hypertrophy                                                                                          1 (2%)                   
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Vacuolization Cytoplasmic                        8 (14%)                   8 (14%)                   7 (12%)                  
   Adrenal Medulla                                    (56)                      (57)                      (58)                      
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                                                       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      6 (11%)                   4 (7%)                    8 (14%)                  
   Islets, Pancreatic                                 (57)                      (58)                      (58)                      
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
   Parathyroid Gland                                  (54)                      (55)                      (55)                      
      Hyperplasia                                                                2 (4%)                    1 (2%)                   
   Pituitary Gland                                    (57)                      (58)                      (58)                      
      Angiectasis                                      4 (7%)                    5 (9%)                    5 (9%)                   
      Cyst                                             5 (9%)                    4 (7%)                    1 (2%)                   
      Hemorrhage                                                                                           2 (3%)                   
      Pars Distalis, Hyperplasia, Diffuse              4 (7%)                    1 (2%)                    3 (5%)                   
      Pars Distalis, Hyperplasia, Focal               13 (23%)                  16 (28%)                  12 (21%)                  
   Thyroid Gland                                      (57)                      (58)                      (58)                      
      Autolysis                                                                                            1 (2%)                   
      Fibrosis                                         1 (2%)                                                                       
      C-Cell, Hyperplasia                              9 (16%)                   7 (12%)                   7 (12%)                  
      Follicular Cell, Hyperplasia                                                                         1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (6)                       (4)                       (2)                       
      Inflammation, Granulomatous                      1 (17%)                                                                      
      Abdominal, Polyarteritis                                                   1 (25%)                                            
      Mediastinum, Inflammation                                                  1 (25%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (56)                      (57)                      (57)                      
      Ectasia                                          4 (7%)                    7 (12%)                   2 (4%)                   
      Hyperplasia                                      2 (4%)                    1 (2%)                    1 (2%)                   
      Hyperplasia, Squamous                            1 (2%)                                                                       
      Inflammation                                     1 (2%)                                              2 (4%)                   
   Ovary                                              (57)                      (58)                      (58)                      
      Atrophy                                                                    2 (3%)                                             
      Cyst                                             7 (12%)                   5 (9%)                    4 (7%)                   
   Uterus                                             (57)                      (58)                      (58)                      
      Hemorrhage                                                                 1 (2%)                    1 (2%)                   
      Endometrium, Fibrosis                            2 (4%)                                                                       
      Endometrium, Hyperplasia                         1 (2%)                    1 (2%)                    2 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (57)                      (58)                      (58)                      
      Atrophy                                          2 (4%)                                                                       
      Atrophy, Diffuse                                                           1 (2%)                                             
      Atrophy, Focal                                                                                       1 (2%)                   
      Autolysis                                                                  1 (2%)                                             
      Hyperplasia                                                                1 (2%)                    1 (2%)                   
      Hyperplasia, Reticulum Cell                                                1 (2%)                                             
      Myeloid Cell, Hyperplasia                        8 (14%)                  10 (17%)                  10 (17%)                  
   Lymph Node                                         (8)                       (7)                       (11)                      
      Iliac, Hyperplasia, Lymphoid                                               1 (14%)                                            
   Lymph Node, Bronchial                              (54)         (5)          (57)         (5)          (54)         (4)          
      Congestion                                                                 4 (7%)                    2 (4%)                   
      Hyperplasia, Lymphoid                            2 (4%)       1 (20%)      1 (2%)       4 (80%)                   4 (100%)    
      Hyperplasia, Plasma Cell                                                                             1 (2%)                   
   Lymph Node, Mandibular                             (57)                      (57)                      (56)                      
      Autolysis                                                                  1 (2%)                                             
      Hyperplasia, Lymphoid                            5 (9%)                    3 (5%)                    5 (9%)                   
      Hyperplasia, Plasma Cell                                                   2 (4%)                                             
      Inflammation, Granulomatous                      1 (2%)                                                                       
   Lymph Node, Mesenteric                             (57)                      (58)                      (58)                      
      Autolysis                                                                  1 (2%)                    1 (2%)                   
      Congestion                                       2 (4%)                    2 (3%)                    2 (3%)                   
      Edema                                                                      1 (2%)                                             
      Hyperplasia, Histiocytic                                                   1 (2%)                                             
      Infarct                                          1 (2%)                                                                       
      Inflammation                                                               1 (2%)                                             
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Pigmentation, Hemosiderin                        1 (2%)                    1 (2%)                    3 (5%)                   
   Lymph Node, Mediastinal                            (53)         (3)          (54)         (5)          (48)         (5)          
      Autolysis                                        1 (2%)                    2 (4%)                                             
      Congestion                                       3 (6%)                    6 (11%)                   1 (2%)                   
      Hyperplasia, Histiocytic                                                   1 (2%)                                             
      Hyperplasia, Lymphoid                            2 (4%)                    4 (7%)       2 (40%)      2 (4%)       2 (40%)     
      Inflammation, Granulomatous                      1 (2%)                                                                       
   Spleen                                             (57)                      (57)                      (58)                      
      Angiectasis                                                                                          1 (2%)                   
      Atrophy                                          1 (2%)                                                                       
      Fibrosis                                         3 (5%)                    2 (4%)                    6 (10%)                  
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Hyperplasia, Re Cell                                                                                 1 (2%)                   
      Infarct                                          1 (2%)                                                                       
      Metaplasia, Osseous                              1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
   Thymus                                             (53)                      (54)                      (56)                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Atrophy                                         14 (26%)                  19 (35%)                  13 (23%)                  
      Autolysis                                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (57)                      (58)                      (58)                      
      Hyperplasia                                                                1 (2%)                    1 (2%)                   
      Hyperplasia, Focal                                                         1 (2%)                                             
      Duct, Ectasia                                                              2 (3%)                                             
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Skin                                               (58)                      (58)                      (57)                      
      Cyst Epithelial Inclusion                        1 (2%)                    1 (2%)                                             
      Inflammation                                     1 (2%)                                                                       
      Dermis, Edema                                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (58)                      (58)                      (58)                      
      Fracture                                                                                             1 (2%)                   
      Hyperostosis                                     4 (7%)                    1 (2%)                    2 (3%)                   
      Ligament, Intervertebral Disc, Degeneration      1 (2%)                                                                       
      Tibia, Fracture                                                                                      1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (57)                      (58)                      (58)                      
      Autolysis                                                                                            1 (2%)                   
      Compression                                      9 (16%)                  14 (24%)                   5 (9%)                   
      Degeneration                                                                                         1 (2%)                   
      Hemorrhage                                                                 2 (3%)                                             
      Necrosis                                                                                             1 (2%)                   
      Meninges, Inflammation                           1 (2%)                                                                       
      Ventricle, Hydrocephalus                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (56)                      (57)                      (57)                      
      Hyperplasia                                                                1 (2%)                    1 (2%)                   
      Inflammation                                     9 (16%)                  13 (23%)                  21 (37%)                  
      Metaplasia, Squamous                                                       1 (2%)                                             
   Lung                                               (57)         (5)          (58)         (5)          (58)         (5)          
      Congestion                                       1 (2%)                    1 (2%)                    1 (2%)                   
      Fibrosis                                         8 (14%)                   7 (12%)                  46 (79%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Macrophage                         10 (18%)                  11 (19%)      2 (40%)     35 (60%)      4 (80%)     
      Inflammation, Chronic Active                    16 (28%)                  13 (22%)      2 (40%)     53 (91%)      4 (80%)     
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal          6 (11%)                   3 (5%)                    7 (12%)                  
      Alveolus, Proteinosis                            1 (2%)                                             25 (43%)                  
      Interstitium, Infiltration Cellular             14 (25%)      1 (20%)     10 (17%)      4 (80%)      4 (7%)       5 (100%)    
   Nose                                               (56)         (5)          (57)         (5)          (58)         (5)          
      Thrombosis                                       4 (7%)                    4 (7%)                    5 (9%)                   
      Thrombosis, Multiple                             1 (2%)                                                                       
      Nasolacrimal Duct, Ectasia                       1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation                  5 (9%)                    4 (7%)                    1 (2%)                   
      Nasopharyngeal Duct, Hyperplasia                                           1 (2%)                    1 (2%)                   
      Nasopharyngeal Duct, Inflammation                                          1 (2%)                    1 (2%)                   
      Olfactory Epithelium, Atrophy                                              1 (2%)                    1 (2%)                   
      Olfactory Epithelium, Degeneration              45 (80%)      2 (40%)     20 (35%)      1 (20%)     11 (19%)                  
      Olfactory Epithelium, Erosion                                                                        1 (2%)                   
      Olfactory Epithelium, Inflammation               1 (2%)                                              3 (5%)                   
      Olfactory Epithelium, Metaplasia                 1 (2%)                                              1 (2%)                   
      Olfactory Epithelium, Metaplasia, Squamous       1 (2%)                                                                       
      Respiratory Epithelium, Degeneration            14 (25%)      1 (20%)     17 (30%)                   5 (9%)                   
      Respiratory Epithelium, Erosion                                                                      1 (2%)                   
      Respiratory Epithelium, Hyperplasia              9 (16%)                  17 (30%)                  17 (29%)                  
      Respiratory Epithelium, Inflammation            13 (23%)      1 (20%)      8 (14%)                  12 (21%)                  
      Respiratory Epithelium, Metaplasia, Squamous     1 (2%)                                                                       
      Vomeronasal Organ, Inflammation                  1 (2%)                                                                       
   Trachea                                            (57)                      (58)                      (58)                      
      Hyperplasia                                                                                          1 (2%)                   
      Inflammation                                                               1 (2%)                    1 (2%)                   
      Metaplasia, Squamous                                                                                 1 (2%)                   
      Epithelium, Hyperplasia                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                       (5)                       (1)                       
      Inflammation                                                               1 (20%)                                            
      Phthisis Bulbi                                                             1 (20%)                                            
      Synechia                                                                   1 (20%)                                            
      Anterior Chamber, Inflammation                   1 (50%)                   1 (20%)                                            
      Cornea, Fibrosis                                                                                     1 (100%)                 
      Posterior Chamber, Inflammation                  1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (57)         (5)          (58)         (5)          (58)         (5)          
      Autolysis                                        2 (4%)                    1 (2%)                                             
      Congestion                                       1 (2%)                                                                       
      Cyst                                                                       1 (2%)                                             
      Degeneration, Fatty                                                                                  1 (2%)                   
      Infarct                                                                                              1 (2%)                   
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Nephropathy                                     43 (75%)                  41 (71%)                  41 (71%)                  
      Pelvis, Dilatation                               1 (2%)                    1 (2%)                    2 (3%)                   
      Renal Tubule, Degeneration                                                                           1 (2%)                   
      Renal Tubule, Necrosis                           1 (2%)                                              1 (2%)                   
      Renal Tubule, Pigmentation                       3 (5%)                    8 (14%)                   8 (14%)                  
   Urinary Bladder                                    (58)                      (58)                      (58)                      
      Inflammation                                                               1 (2%)                                             
      Inflammation, Granulomatous                      1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.5MG/M3     0.5MG/M3                                                            
                                                                LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           10                                                               
  Scheduled Sacrifice                                  5           10                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                21                                                                            
    Accidently Killed                                  1                                                                            
    Natural Death                                      3                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                29                                                                            
  Missing                                              1                                                                            
  Animals Examined Microscopically                    59            5                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (59)                                                                          
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Large, Rectum                            (50)                                                                          
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Large, Cecum                             (58)                                                                          
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Small, Jejunum                           (59)                                                                          
      Peyer's Patch, Hyperplasia                       3 (5%)                                                                       
   Liver                                              (59)                                                                          
      Basophilic Focus                                45 (76%)                                                                      
      Clear Cell Focus                                 4 (7%)                                                                       
      Congestion                                       1 (2%)                                                                       
      Degeneration, Cystic                             4 (7%)                                                                       
      Degeneration, Fatty                              7 (12%)                                                                      
      Eosinophilic Focus                               3 (5%)                                                                       
      Hepatodiaphragmatic Nodule                       8 (14%)                                                                      
      Mixed Cell Focus                                 1 (2%)                                                                       
      Bile Duct, Hyperplasia                          12 (20%)                                                                      
      Centrilobular, Atrophy                           2 (3%)                                                                       
      Hepatocyte, Necrosis                             8 (14%)                                                                      
   Pancreas                                           (59)                                                                          
      Necrosis                                         1 (2%)                                                                       
      Acinus, Atrophy                                  1 (2%)                                                                       
   Stomach, Forestomach                               (58)                                                                          
      Inflammation                                     1 (2%)                                                                       
      Ulcer                                            2 (3%)                                                                       
   Tooth                                              (1)                                                                           
      Peridontal Tissue, Inflammation                  1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.5MG/M3     0.5MG/M3                                                            
                                                                LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)                                                                          
      Cardiomyopathy                                  13 (22%)                                                                      
      Thrombosis                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)                                                                          
      Cytoplasmic Alteration                           1 (2%)                                                                       
      Hyperplasia                                      8 (14%)                                                                      
      Necrosis                                         1 (2%)                                                                       
      Vacuolization Cytoplasmic                       16 (27%)                                                                      
   Adrenal Medulla                                    (59)                                                                          
      Hyperplasia                                      8 (14%)                                                                      
   Islets, Pancreatic                                 (59)                                                                          
      Hyperplasia                                      1 (2%)                                                                       
   Parathyroid Gland                                  (52)                                                                          
      Hyperplasia, Focal                               1 (2%)                                                                       
   Pituitary Gland                                    (59)                                                                          
      Angiectasis                                      2 (3%)                                                                       
      Autolysis                                        1 (2%)                                                                       
      Cyst                                             4 (7%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Diffuse              1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal               13 (22%)                                                                      
   Thyroid Gland                                      (57)                                                                          
      Autolysis                                        1 (2%)                                                                       
      C-Cell, Hyperplasia                              8 (14%)                                                                      
      Follicular Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (5)                                                                           
      Hemorrhage                                       1 (20%)                                                                      
      Oral, Inflammation, Granulomatous                1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (59)                                                                          
      Ectasia                                          3 (5%)                                                                       
      Hyperplasia                                      3 (5%)                                                                       
      Hyperplasia, Squamous                            1 (2%)                                                                       
      Inflammation                                     1 (2%)                                                                       
   Ovary                                              (59)                                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.5MG/M3     0.5MG/M3                                                            
                                                                LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Atrophy                                          1 (2%)                                                                       
      Congestion                                       1 (2%)                                                                       
      Cyst                                             5 (8%)                                                                       
      Bilateral, Cyst                                  1 (2%)                                                                       
   Uterus                                             (59)                                                                          
      Fibrosis                                         1 (2%)                                                                       
      Inflammation                                     1 (2%)                                                                       
      Endometrium, Hyperplasia                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)                                                                          
      Necrosis                                         1 (2%)                                                                       
      Myeloid Cell, Hyperplasia                        9 (15%)                                                                      
   Lymph Node, Bronchial                              (54)         (5)                                                              
      Hyperplasia, Lymphoid                           12 (22%)      4 (80%)                                                         
   Lymph Node, Mandibular                             (54)                                                                          
      Hyperplasia, Lymphoid                            3 (6%)                                                                       
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
   Lymph Node, Mesenteric                             (59)                                                                          
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Hyperplasia, Macrophage                          1 (2%)                                                                       
      Pigmentation, Hemosiderin                        2 (3%)                                                                       
   Lymph Node, Mediastinal                            (52)         (5)                                                              
      Congestion                                       1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Hyperplasia, Lymphoid                            7 (13%)      2 (40%)                                                         
      Pigmentation                                     4 (8%)                                                                       
   Spleen                                             (59)                                                                          
      Atrophy                                          1 (2%)                                                                       
      Autolysis                                        1 (2%)                                                                       
      Fibrosis                                         3 (5%)                                                                       
      Hematopoietic Cell Proliferation                 3 (5%)                                                                       
      Inflammation, Focal                              1 (2%)                                                                       
   Thymus                                             (57)                                                                          
      Atrophy                                         13 (23%)                                                                      
      Autolysis                                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)                                                                          
      Duct, Ectasia                                    1 (2%)                                                                       
      Duct, Hyperplasia                                1 (2%)                                                                       
   Skin                                               (58)                                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.5MG/M3     0.5MG/M3                                                            
                                                                LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Inflammation                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (59)                                                                          
      Hyperostosis                                     3 (5%)                                                                       
   Skeletal Muscle                                    (1)                                                                           
      Hemorrhage                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)                                                                          
      Compression                                      5 (8%)                                                                       
      Degeneration                                     1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Hydrocephalus                                    1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
   Spinal Cord                                        (1)                                                                           
      Meninges, Hemorrhage                             1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (58)                                                                          
      Hyperplasia                                      2 (3%)                                                                       
      Inflammation                                    15 (26%)                                                                      
      Metaplasia, Squamous                             1 (2%)                                                                       
   Lung                                               (59)         (5)                                                              
      Cyst, Squamous                                   2 (3%)                                                                       
      Fibrosis                                        52 (88%)                                                                      
      Hyperplasia, Macrophage                         50 (85%)      5 (100%)                                                        
      Inflammation, Chronic Active                    57 (97%)      5 (100%)                                                        
      Alveolar Epithelium, Hyperplasia                 1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal         10 (17%)                                                                      
      Alveolar Epithelium, Metaplasia, Squamous        4 (7%)                                                                       
      Alveolus, Proteinosis                           54 (92%)      2 (40%)                                                         
      Interstitium, Infiltration Cellular             11 (19%)      3 (60%)                                                         
   Nose                                               (59)         (5)                                                              
      Congestion                                       1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Thrombosis                                       3 (5%)                                                                       
      Thrombosis, Multiple                             1 (2%)                                                                       
      Nasolacrimal Duct, Hyperplasia                   1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation                  8 (14%)                                                                      
      Nasopharyngeal Duct, Hyperplasia                 1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0.5MG/M3     0.5MG/M3                                                            
                                                                LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Nasopharyngeal Duct, Inflammation                1 (2%)                                                                       
      Olfactory Epithelium, Atrophy                    8 (14%)      1 (20%)                                                         
      Olfactory Epithelium, Degeneration              12 (20%)                                                                      
      Respiratory Epithelium, Degeneration             4 (7%)                                                                       
      Respiratory Epithelium, Hyperplasia             17 (29%)                                                                      
      Respiratory Epithelium, Inflammation            13 (22%)      3 (60%)                                                         
   Trachea                                            (59)                                                                          
      Autolysis                                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (7)          (1)                                                              
      Cataract                                         1 (14%)      1 (100%)                                                        
      Hemorrhage                                       1 (14%)                                                                      
      Phthisis Bulbi                                   3 (43%)                                                                      
      Synechia                                         2 (29%)                                                                      
      Anterior Chamber, Inflammation                   1 (14%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (5)                                                              
      Autolysis                                        2 (3%)                                                                       
      Nephropathy                                     44 (75%)                                                                      
      Pigmentation                                     1 (2%)                                                                       
      Renal Tubule, Degeneration                       1 (2%)                                                                       
      Renal Tubule, Necrosis, Acute                    1 (2%)                                                                       
      Renal Tubule, Pigmentation                       6 (10%)                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          59           11           58           12           58           12           
  Scheduled Sacrifice                                  5           11            5           12            5           12           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                34                        30                        31                        
    Natural Death                                      4                         7                         3                        
    Accidently Killed                                                                                      1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                16                        16                        18                        
  Animals Examined Microscopically                    59            5           58            5           58            5           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (59)                      (58)                      (58)                      
      Autolysis                                                                  1 (2%)                    1 (2%)                   
      Parasite Metazoan                                1 (2%)                    2 (3%)                                             
   Intestine Large, Rectum                            (59)                      (58)                      (57)                      
      Autolysis                                                                  1 (2%)                    1 (2%)                   
      Parasite Metazoan                                1 (2%)                    1 (2%)                    1 (2%)                   
   Intestine Large, Cecum                             (59)                      (58)                      (58)                      
      Autolysis                                                                  1 (2%)                    1 (2%)                   
      Parasite Metazoan                                                          1 (2%)                    1 (2%)                   
   Intestine Small, Duodenum                          (59)                      (58)                      (56)                      
      Autolysis                                                                  1 (2%)                                             
      Ulcer                                            1 (2%)                                                                       
   Intestine Small, Jejunum                           (59)                      (57)                      (55)                      
      Autolysis                                                                  1 (2%)                                             
      Peyer's Patch, Hyperplasia                       2 (3%)                    1 (2%)                    1 (2%)                   
   Intestine Small, Ileum                             (59)                      (55)                      (53)                      
      Autolysis                                                                  1 (2%)                                             
   Liver                                              (59)                      (58)                      (58)                      
      Angiectasis                                      6 (10%)                  11 (19%)                   4 (7%)                   
      Autolysis                                                                  1 (2%)                    2 (3%)                   
      Basophilic Focus                                34 (58%)                  32 (55%)                  46 (79%)                  
      Clear Cell Focus                                 2 (3%)                    5 (9%)                    2 (3%)                   
      Congestion                                       2 (3%)                                              2 (3%)                   
      Cyst                                             1 (2%)                                                                       
      Degeneration, Cystic                            11 (19%)                  13 (22%)                   7 (12%)                  
      Degeneration, Fatty                              6 (10%)                   5 (9%)                   12 (21%)                  
      Eosinophilic Focus                               5 (8%)                    7 (12%)                   5 (9%)                   
      Fatty Change                                                                                         1 (2%)                   
      Hepatodiaphragmatic Nodule                       5 (8%)                    2 (3%)                    6 (10%)                  
      Infarct                                          1 (2%)                                                                       
      Mixed Cell Focus                                 2 (3%)                    3 (5%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Thrombosis                                       4 (7%)                    1 (2%)                                             
      Bile Duct, Hyperplasia                          36 (61%)                  33 (57%)                  37 (64%)                  
      Centrilobular, Atrophy                           6 (10%)                   4 (7%)                    5 (9%)                   
      Hepatocyte, Hyperplasia                          1 (2%)                    2 (3%)                    1 (2%)                   
      Hepatocyte, Necrosis                            16 (27%)                  18 (31%)                  12 (21%)                  
   Mesentery                                          (2)                       (4)                                                 
      Cyst                                                                       1 (25%)                                            
      Fat, Necrosis                                    1 (50%)                                                                      
   Oral Mucosa                                        (3)                       (2)                       (4)                       
      Hyperplasia, Squamous                            1 (33%)                   1 (50%)                                            
   Pancreas                                           (58)                      (57)                      (58)                      
      Autolysis                                                                                            2 (3%)                   
      Cytoplasmic Alteration                           1 (2%)                                                                       
      Infarct                                          1 (2%)                                                                       
      Acinus, Atrophy                                  6 (10%)                   6 (11%)                   9 (16%)                  
      Acinus, Hyperplasia                                                        1 (2%)                    1 (2%)                   
   Stomach, Forestomach                               (59)                      (58)                      (57)                      
      Diverticulum                                                               1 (2%)                                             
      Hyperplasia, Squamous                            1 (2%)                                                                       
      Inflammation                                     1 (2%)                                                                       
      Perforation                                      1 (2%)                                                                       
      Ulcer                                            4 (7%)                    1 (2%)                    2 (4%)                   
   Stomach, Glandular                                 (59)                      (58)                      (58)                      
      Autolysis                                                                  1 (2%)                                             
      Erosion                                          1 (2%)                                                                       
      Inflammation                                                               2 (3%)                                             
      Necrosis                                         1 (2%)                                              1 (2%)                   
      Ulcer                                                                                                1 (2%)                   
   Tooth                                              (9)                       (3)                       (3)                       
      Developmental Malformation                                                                           2 (67%)                  
      Peridontal Tissue, Hyperplasia                                                                       1 (33%)                  
      Peridontal Tissue, Inflammation                  9 (100%)                  3 (100%)                  1 (33%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)                      (58)                      (58)                      
      Autolysis                                                                                            1 (2%)                   
      Cardiomyopathy                                  31 (53%)                  31 (53%)                  29 (50%)                  
      Inflammation                                                               1 (2%)                                             
      Proliferation Connective Tissue                                                                      1 (2%)                   
      Thrombosis                                       8 (14%)                   5 (9%)                    5 (9%)                   
      Epicardium, Inflammation                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)                      (58)                      (58)                      
      Atrophy                                          1 (2%)                    3 (5%)                                             
      Autolysis                                                                                            1 (2%)                   
      Cyst                                                                       1 (2%)                                             
      Cytoplasmic Alteration                                                     1 (2%)                                             
      Hyperplasia                                      3 (5%)                    7 (12%)                   4 (7%)                   
      Hypertrophy                                      1 (2%)                                                                       
      Vacuolization Cytoplasmic                       11 (19%)                  10 (17%)                  17 (29%)                  
      Capsule, Fibrosis                                                                                    1 (2%)                   
   Adrenal Medulla                                    (59)                      (58)                      (58)                      
      Autolysis                                                                                            1 (2%)                   
      Cyst                                             1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                     28 (47%)                  20 (34%)                  18 (31%)                  
   Islets, Pancreatic                                 (57)                      (56)                      (57)                      
      Hyperplasia                                      2 (4%)                    2 (4%)                    2 (4%)                   
   Parathyroid Gland                                  (54)                      (54)                      (56)                      
      Hyperplasia                                      3 (6%)                    2 (4%)                    1 (2%)                   
   Pituitary Gland                                    (59)                      (56)                      (58)                      
      Angiectasis                                      3 (5%)                    7 (13%)                   3 (5%)                   
      Hemorrhage                                       1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Diffuse                                        2 (4%)                                             
      Pars Distalis, Hyperplasia, Focal               16 (27%)                  16 (29%)                  16 (28%)                  
   Thyroid Gland                                      (58)                      (58)                      (56)                      
      Autolysis                                                                  1 (2%)                    1 (2%)                   
      C-Cell, Hyperplasia                              5 (9%)                    7 (12%)                   8 (14%)                  
      Follicular Cell, Hyperplasia, Cystic             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (4)                       (1)                       (5)                       
      Mediastinum, Polyarteritis                       1 (25%)                                                                      
      Oral, Inflammation                               1 (25%)                                                                      
      Pelvic, Ectopic Tissue                                                                               1 (20%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (1)                       (3)                                                 
      Inflammation                                     1 (100%)                  3 (100%)                                           
   Penis                                              (1)                                                                           
      Inflammation                                     1 (100%)                                                                     
   Preputial Gland                                    (59)                      (58)                      (57)                      
      Atrophy                                          1 (2%)                    2 (3%)                    2 (4%)                   
      Autolysis                                                                                            1 (2%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Ectasia                                          2 (3%)                    5 (9%)                    5 (9%)                   
      Hyperplasia                                      3 (5%)                                              1 (2%)                   
      Infiltration Cellular                            1 (2%)                                                                       
      Inflammation                                     2 (3%)                    5 (9%)                    1 (2%)                   
   Prostate                                           (59)                      (57)                      (58)                      
      Inflammation                                     1 (2%)                    4 (7%)                    4 (7%)                   
   Seminal Vesicle                                    (59)                      (58)                      (58)                      
      Atrophy                                          2 (3%)                    3 (5%)                    7 (12%)                  
      Autolysis                                                                                            1 (2%)                   
      Ectasia                                          1 (2%)                                                                       
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Cystic                                                        1 (2%)                                             
      Inflammation                                                                                         1 (2%)                   
   Testes                                             (59)                      (58)                      (58)                      
      Atrophy                                          7 (12%)                   3 (5%)                   10 (17%)                  
      Cyst                                             1 (2%)                    1 (2%)                                             
      Germinal Epithelium, Degeneration                                                                    1 (2%)                   
      Interstitial Cell, Hyperplasia, Focal           11 (19%)                   7 (12%)                   6 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)                      (57)                      (57)                      
      Atrophy                                          1 (2%)                    1 (2%)                    1 (2%)                   
      Atrophy, Focal                                   1 (2%)                                              2 (4%)                   
      Hyperplasia                                                                                          1 (2%)                   
      Erythroid Cell, Hyperplasia                      2 (3%)                    1 (2%)                                             
      Myeloid Cell, Hyperplasia                       17 (29%)                  11 (19%)                  18 (32%)                  
   Lymph Node                                         (11)                      (14)                      (11)                      
      Iliac, Pigmentation                                                                                  1 (9%)                   
      Inguinal, Hyperplasia, Lymphoid                                                                      1 (9%)                   
      Inguinal, Inflammation, Granulomatous                                      1 (7%)                                             
      Pancreatic, Inflammation                                                                             1 (9%)                   
      Renal, Inflammation                              1 (9%)                                                                       
      Renal, Pigmentation, Hemosiderin                 1 (9%)                                                                       
   Lymph Node, Bronchial                              (56)         (5)          (54)         (5)          (52)         (5)          
      Autolysis                                                                  1 (2%)                                             
      Congestion                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                                                                   5 (100%)     4 (8%)       2 (40%)     
      Hyperplasia, Plasma Cell                                                                             2 (4%)                   
      Inflammation                                     2 (4%)                                                                       
   Lymph Node, Mandibular                             (55)                      (57)                      (56)                      
      Hyperplasia, Lymphoid                            5 (9%)                    3 (5%)                    9 (16%)                  
      Hyperplasia, Plasma Cell                         1 (2%)                    2 (4%)                    6 (11%)                  
      Inflammation                                                                                         1 (2%)                   
   Lymph Node, Mesenteric                             (59)                      (58)                      (58)                      
      Autolysis                                                                  1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Congestion                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                    2 (3%)                   
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
   Lymph Node, Mediastinal                            (56)         (3)          (52)         (5)          (51)         (4)          
      Autolysis                                        1 (2%)                    2 (4%)                                             
      Congestion                                                                 2 (4%)                    3 (6%)                   
      Hyperplasia, Lymphoid                            3 (5%)                    3 (6%)       4 (80%)      5 (10%)      2 (50%)     
      Hyperplasia, Macrophage                          1 (2%)                                              1 (2%)                   
      Hyperplasia, Plasma Cell                                                   1 (2%)                                             
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
   Spleen                                             (59)                      (58)                      (56)                      
      Angiectasis                                                                2 (3%)                                             
      Atrophy                                          1 (2%)                    2 (3%)                    1 (2%)                   
      Autolysis                                        1 (2%)                    1 (2%)                                             
      Congestion                                       5 (8%)                    2 (3%)                    1 (2%)                   
      Fibrosis                                        13 (22%)                  16 (28%)                  14 (25%)                  
      Hematopoietic Cell Proliferation                                           1 (2%)                    1 (2%)                   
      Infarct                                                                    1 (2%)                    1 (2%)                   
      Pigmentation, Hemosiderin                                                  2 (3%)                                             
   Thymus                                             (54)                      (53)                      (53)         (1)          
      Atrophy                                         16 (30%)                  13 (25%)                  10 (19%)                  
      Autolysis                                                                  1 (2%)                                             
      Congestion                                       1 (2%)                    1 (2%)                                 1 (100%)    
      Cyst                                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)                      (53)                      (53)                      
      Hemorrhage                                                                                           1 (2%)                   
   Skin                                               (58)                      (58)                      (58)                      
      Angiectasis                                      1 (2%)                                                                       
      Cyst Epithelial Inclusion                                                  3 (5%)                    1 (2%)                   
      Inflammation                                     2 (3%)                                                                       
      Prepuce, Fibrosis                                                                                    1 (2%)                   
      Sebaceous Gland, Inflammation                                                                        1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (59)                      (58)                      (58)                      
      Fibrous Osteodystrophy                           1 (2%)                                                                       
      Hyperostosis                                     2 (3%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)                      (58)                      (58)         (1)          
      Compression                                      5 (8%)                    5 (9%)                    5 (9%)                   
      Degeneration                                                               2 (3%)                                             
      Hemorrhage                                       3 (5%)                    2 (3%)                    1 (2%)                   
      Hydrocephalus                                                              1 (2%)                                             
      Infarct                                                                    1 (2%)                                             
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
      Ventricle, Hydrocephalus                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (59)                      (57)                      (58)                      
      Hyperplasia                                                                                          3 (5%)                   
      Inflammation                                     8 (14%)                   9 (16%)                  13 (22%)                  
      Metaplasia, Squamous                                                                                 1 (2%)                   
   Lung                                               (59)         (5)          (58)         (5)          (58)         (5)          
      Autolysis                                                                  1 (2%)                                             
      Congestion                                       2 (3%)                    3 (5%)                    2 (3%)                   
      Emphysema                                                                  1 (2%)                                             
      Fibrosis                                         3 (5%)                    6 (10%)                  35 (60%)                  
      Hemorrhage                                       2 (3%)                    5 (9%)                    1 (2%)                   
      Hyperplasia, Macrophage                          7 (12%)                   9 (16%)      1 (20%)     37 (64%)      5 (100%)    
      Inflammation, Chronic Active                    14 (24%)                  12 (21%)      4 (80%)     43 (74%)      4 (80%)     
      Metaplasia, Osseous                              1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal          3 (5%)                    2 (3%)                    4 (7%)                   
      Alveolus, Proteinosis                                                                               13 (22%)                  
      Interstitium, Infiltration Cellular             12 (20%)      2 (40%)      2 (3%)       5 (100%)     3 (5%)       5 (100%)    
   Nose                                               (59)         (5)          (57)         (5)          (58)         (5)          
      Thrombosis                                                                 6 (11%)                   4 (7%)                   
      Thrombosis, Multiple                             8 (14%)                   1 (2%)                    4 (7%)                   
      Glands, Inflammation                                                                                 1 (2%)                   
      Nasolacrimal Duct, Inflammation                  4 (7%)                    4 (7%)                    4 (7%)                   
      Nasopharyngeal Duct, Hyperplasia                                           2 (4%)                                             
      Nasopharyngeal Duct, Hyperplasia, Lymphoid                                 1 (2%)                                             
      Nasopharyngeal Duct, Inflammation                2 (3%)                    4 (7%)                    2 (3%)                   
      Olfactory Epithelium, Atrophy                                                                        3 (5%)       1 (20%)     
      Olfactory Epithelium, Degeneration              39 (66%)                  19 (33%)                  14 (24%)                  
      Olfactory Epithelium, Inflammation                                                                   1 (2%)                   
      Olfactory Epithelium, Metaplasia, Squamous                                                           1 (2%)                   
      Olfactory Epithelium, Necrosis                                             1 (2%)                                             
      Respiratory Epithelium, Degeneration             2 (3%)                    1 (2%)                    1 (2%)       1 (20%)     
      Respiratory Epithelium, Hyperplasia             18 (31%)                  16 (28%)      1 (20%)     27 (47%)                  
      Respiratory Epithelium, Inflammation            14 (24%)                  13 (23%)                  18 (31%)                  
      Respiratory Epithelium, Metaplasia, Squamous     2 (3%)                    2 (4%)                    2 (3%)       1 (20%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   19                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.0MG/M3     0.0MG/M3     0.12         0.12MGM3     0.25         0.25MGM3        
                                                                LUNG TOX     MG/M3        LUNG TOX     MG/M3        LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Vomeronasal Organ, Inflammation                  1 (2%)                                              1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                                                 (1)                       
      Cataract                                         1 (100%)                                            1 (100%)                 
      Retinal Detachment                               1 (100%)                                                                     
      Synechia                                         1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (5)          (57)         (5)          (57)         (5)          
      Autolysis                                                                                            2 (4%)                   
      Cyst                                             2 (3%)                    1 (2%)                                             
      Infarct                                          1 (2%)                    2 (4%)                    2 (4%)                   
      Inflammation                                                               1 (2%)                    1 (2%)                   
      Nephropathy                                     55 (93%)                  50 (88%)      1 (20%)     49 (86%)                  
      Renal Tubule, Pigmentation                       7 (12%)                   7 (12%)                   8 (14%)                  
   Urethra                                            (1)                       (3)                                                 
      Calculus Micro Observation Only                  1 (100%)                  3 (100%)                                           
   Urinary Bladder                                    (59)                      (58)         (3)          (58)         (1)          
      Autolysis                                                                  1 (2%)                                             
      Calculus Micro Observation Only                  3 (5%)                    4 (7%)       3 (100%)     6 (10%)      1 (100%)    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   20                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.5MG/M3     0.5MG/M3                                                            
                                                                LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          58           12                                                               
  Scheduled Sacrifice                                  5           12                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                28                                                                            
    Natural Death                                      4                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                20                                                                            
    Moribund Sacrifice                                 1                                                                            
  Animals Examined Microscopically                    58            5                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (57)                                                                          
      Parasite Metazoan                                2 (4%)                                                                       
   Intestine Large, Cecum                             (57)                                                                          
      Parasite Metazoan                                2 (4%)                                                                       
   Intestine Small, Jejunum                           (58)                                                                          
      Peyer's Patch, Hyperplasia                       4 (7%)                                                                       
   Liver                                              (58)                                                                          
      Angiectasis                                     10 (17%)                                                                      
      Basophilic Focus                                40 (69%)                                                                      
      Clear Cell Focus                                 4 (7%)                                                                       
      Degeneration, Cystic                             8 (14%)                                                                      
      Degeneration, Fatty                              8 (14%)                                                                      
      Eosinophilic Focus                               5 (9%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       8 (14%)                                                                      
      Mixed Cell Focus                                 1 (2%)                                                                       
      Thrombosis                                       1 (2%)                                                                       
      Bile Duct, Hyperplasia                          35 (60%)                                                                      
      Centrilobular, Atrophy                           7 (12%)                                                                      
      Hepatocyte, Necrosis                            16 (28%)                                                                      
   Pancreas                                           (58)                                                                          
      Atrophy, Focal                                   1 (2%)                                                                       
      Inflammation, Focal                              1 (2%)                                                                       
      Polyarteritis                                    1 (2%)                                                                       
      Thrombosis                                       1 (2%)                                                                       
      Acinus, Atrophy                                  6 (10%)                                                                      
   Stomach, Forestomach                               (57)                                                                          
      Edema                                            1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
   Stomach, Glandular                                 (58)                                                                          
      Ulcer                                            1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   21                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.5MG/M3     0.5MG/M3                                                            
                                                                LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Tooth                                              (3)                                                                           
      Peridontal Tissue, Inflammation                  3 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (58)                                                                          
      Cardiomyopathy                                  32 (55%)                                                                      
      Fibrosis                                         1 (2%)                                                                       
      Infarct                                          1 (2%)                                                                       
      Thrombosis                                       2 (3%)                                                                       
      Atrium, Thrombosis                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (58)                                                                          
      Atrophy                                          1 (2%)                                                                       
      Degeneration, Cystic                             1 (2%)                                                                       
      Hyperplasia                                      4 (7%)                                                                       
      Vacuolization Cytoplasmic                       16 (28%)                                                                      
   Adrenal Medulla                                    (58)                                                                          
      Hyperplasia                                     26 (45%)                                                                      
   Islets, Pancreatic                                 (58)                                                                          
      Hyperplasia                                      4 (7%)                                                                       
   Parathyroid Gland                                  (53)                                                                          
      Hyperplasia                                      2 (4%)                                                                       
      Bilateral, Hyperplasia                           1 (2%)                                                                       
   Pituitary Gland                                    (58)                                                                          
      Angiectasis                                      2 (3%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Pigmentation, Ceroid                             1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal               19 (33%)                                                                      
   Thyroid Gland                                      (57)                                                                          
      Autolysis                                        1 (2%)                                                                       
      C-Cell, Hyperplasia                              6 (11%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (4)                                                                           
      Hemorrhage                                       1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   22                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.5MG/M3     0.5MG/M3                                                            
                                                                LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (58)                                                                          
      Granuloma Sperm                                  1 (2%)                                                                       
      Spermatocele                                     1 (2%)                                                                       
   Preputial Gland                                    (58)                                                                          
      Ectasia                                          5 (9%)                                                                       
      Inflammation                                     2 (3%)                                                                       
   Prostate                                           (58)                                                                          
      Inflammation                                     3 (5%)                                                                       
   Seminal Vesicle                                    (58)                                                                          
      Atrophy                                          2 (3%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
   Testes                                             (58)                                                                          
      Atrophy                                          4 (7%)                                                                       
      Infarct                                          1 (2%)                                                                       
      Interstitial Cell, Hyperplasia, Focal            5 (9%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (58)                                                                          
      Atrophy, Focal                                   1 (2%)                                                                       
      Myeloid Cell, Hyperplasia                       18 (31%)                                                                      
   Lymph Node                                         (12)                                                                          
      Iliac, Hyperplasia, Plasma Cell                  1 (8%)                                                                       
      Inguinal, Hyperplasia, Histiocytic               1 (8%)                                                                       
      Pancreatic, Pigmentation, Hemosiderin            1 (8%)                                                                       
      Renal, Pigmentation, Hemosiderin                 1 (8%)                                                                       
   Lymph Node, Bronchial                              (56)         (5)                                                              
      Congestion                                       1 (2%)                                                                       
      Edema                                            2 (4%)                                                                       
      Hyperplasia, Lymphoid                           11 (20%)      5 (100%)                                                        
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
   Lymph Node, Mandibular                             (57)                                                                          
      Hyperplasia, Lymphoid                            6 (11%)                                                                      
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
      Inflammation                                     1 (2%)                                                                       
   Lymph Node, Mediastinal                            (54)         (4)                                                              
      Congestion                                       1 (2%)                                                                       
      Edema                                            2 (4%)                                                                       
      Hyperplasia, Lymphoid                            7 (13%)      2 (50%)                                                         
      Hyperplasia, Macrophage                          1 (2%)                                                                       
      Hyperplasia, Plasma Cell                         2 (4%)                                                                       
      Pigmentation                                     4 (7%)                                                                       
   Spleen                                             (58)                                                                          
      Atrophy                                          1 (2%)                                                                       
      Congestion                                       1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   23                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.5MG/M3     0.5MG/M3                                                            
                                                                LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Fibrosis                                        14 (24%)                                                                      
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Infarct                                          2 (3%)                                                                       
   Thymus                                             (50)                                                                          
      Atrophy                                         17 (34%)                                                                      
      Cyst                                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (58)                                                                          
      Cyst Epithelial Inclusion                        2 (3%)                                                                       
      Edema                                            1 (2%)                                                                       
      Hyperkeratosis                                   1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (58)                                                                          
      Hyperostosis                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (58)                                                                          
      Compression                                      5 (9%)                                                                       
      Degeneration                                     1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (58)                                                                          
      Inflammation                                     8 (14%)                                                                      
      Necrosis                                         1 (2%)                                                                       
   Lung                                               (58)         (5)                                                              
      Congestion                                       1 (2%)                                                                       
      Fibrosis                                        45 (78%)                                                                      
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Macrophage                         53 (91%)      5 (100%)                                                        
      Inflammation, Chronic Active                    51 (88%)      5 (100%)                                                        
      Inflammation, Suppurative                        1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal          2 (3%)       1 (20%)                                                         
      Alveolus, Proteinosis                           45 (78%)                                                                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   24                                                              
NTP Experiment-Test: 05122-05         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                     NICKEL SULFATE HEXAHYDRATE                                Date: 05/20/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 03:00:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0.5MG/M3     0.5MG/M3                                                            
                                                                LUNG TOX                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Bronchus, Hyperplasia, Lymphoid                               2 (40%)                                                         
      Interstitium, Infiltration Cellular             11 (19%)      5 (100%)                                                        
   Nose                                               (58)         (5)                                                              
      Thrombosis                                       1 (2%)                                                                       
      Thrombosis, Multiple                             8 (14%)                                                                      
      Nasolacrimal Duct, Hyperplasia                   1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation                  3 (5%)                                                                       
      Nasopharyngeal Duct, Hyperplasia, Lymphoid       1 (2%)                                                                       
      Nasopharyngeal Duct, Inflammation                1 (2%)                                                                       
      Olfactory Epithelium, Atrophy                    7 (12%)      1 (20%)                                                         
      Olfactory Epithelium, Degeneration              14 (24%)      1 (20%)                                                         
      Olfactory Epithelium, Inflammation               1 (2%)                                                                       
      Respiratory Epithelium, Hyperplasia             34 (59%)      1 (20%)                                                         
      Respiratory Epithelium, Inflammation            25 (43%)                                                                      
      Respiratory Epithelium, Metaplasia, Squamous     6 (10%)      1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                                                                           
      Synechia                                         1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (58)         (5)                                                              
      Cyst                                             1 (2%)                                                                       
      Nephropathy                                     44 (76%)                                                                      
      Renal Tubule, Pigmentation                       8 (14%)                                                                      
   Urethra                                            (1)                                                                           
      Calculus Micro Observation Only                  1 (100%)                                                                     
   Urinary Bladder                                    (58)         (2)                                                              
      Calculus Micro Observation Only                  3 (5%)       2 (100%)                                                        
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   25                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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