TDMS Study 05122-05 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
NICKEL SULFATE HEXAHYDRATE
NTP Experiment-Test: 05122-05 Report: PEIRPT05
Study Type: CHRONIC Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 010101970
Lock Date: 02/03/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 58 12 58 12 59 11
Scheduled Sacrifice 5 12 5 12 5 11
Early Deaths
Moribund Sacrifice 27 32 22
Natural Death 4 4 3
Survivors
Terminal Sacrifice 22 17 28
Other 1
Animals Examined Microscopically 58 5 58 5 58 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (57) (55) (58)
Carcinoma, Metastatic, Pancreas 1 (2%)
Intestine Large, Cecum (56) (58) (58)
Lipoma 1 (2%)
Intestine Small, Duodenum (56) (58) (57)
Carcinoma, Metastatic, Pancreas 1 (2%)
Intestine Small, Jejunum (57) (58) (58)
Carcinoma, Metastatic, Pancreas 1 (2%)
Intestine Small, Ileum (54) (56) (57)
Fibrosarcoma 1 (2%)
Liver (57) (58) (58)
Carcinoma, Metastatic, Pancreas 1 (2%)
Mesentery (1) (2) (2)
Lipoma 1 (50%)
Oral Mucosa (3) (2) (2)
Squamous Cell Carcinoma 3 (100%) 1 (50%) 2 (100%)
Squamous Cell Papilloma 1 (50%)
Pancreas (57) (58) (58)
Carcinoma 1 (2%)
Salivary Glands (57) (58) (58)
Stomach, Forestomach (57) (58) (58)
Carcinoma, Metastatic, Pancreas 1 (2%)
Stomach, Glandular (57) (58) (58)
Carcinoma, Metastatic, Pancreas 1 (2%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (58) (58) (58)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (57) (58) (58)
Adrenal Medulla (56) (57) (58)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 2 (4%) 4 (7%) 2 (3%)
Islets, Pancreatic (57) (58) (58)
Pituitary Gland (57) (58) (58)
Pars Distalis, Adenoma 22 (39%) 24 (41%) 24 (41%)
Thyroid Gland (57) (58) (58)
C-Cell, Adenoma 1 (2%) 2 (3%) 4 (7%)
C-Cell, Carcinoma 1 (2%) 2 (3%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (6) (4) (2)
Pericardial, Carcinoma, Metastatic, Pancreas 1 (17%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (56) (57) (57)
Adenoma 4 (7%) 4 (7%) 3 (5%)
Carcinoma 1 (2%)
Ovary (57) (58) (58)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa Cell Tumor Benign 1 (2%)
Uterus (57) (58) (58)
Carcinoma, Metastatic, Pancreas 1 (2%)
Polyp Stromal 5 (9%) 3 (5%) 4 (7%)
Schwannoma Malignant 1 (2%)
Vagina (1) (1) (1)
Carcinoma, Metastatic, Pancreas 1 (100%)
Fibroma 1 (100%)
Schwannoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (57) (58) (58)
Lymph Node (8) (7) (11)
Iliac, Carcinoma, Metastatic, Pancreas 1 (13%)
Pancreatic, Carcinoma, Metastatic, Pancreas 1 (13%)
Lymph Node, Bronchial (54) (5) (57) (5) (54) (4)
Carcinoma, Metastatic, Pancreas 1 (2%)
Lymph Node, Mandibular (57) (57) (56)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (2%)
Lymph Node, Mesenteric (57) (58) (58)
Lymph Node, Mediastinal (53) (3) (54) (5) (48) (5)
Carcinoma, Metastatic, Pancreas 1 (2%)
Spleen (57) (57) (58)
Carcinoma, Metastatic, Pancreas 1 (2%)
Thymus (53) (54) (56)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (57) (58) (58)
Adenocarcinoma 4 (7%) 4 (7%) 1 (2%)
Adenoma 1 (2%)
Fibroadenoma 14 (25%) 16 (28%) 8 (14%)
Fibroadenoma, Multiple 3 (5%) 2 (3%) 2 (3%)
Skin (58) (58) (57)
Fibroma 1 (2%)
Plasma Cell Tumor Malignant 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (58) (58) (58)
Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (57) (58) (58)
Astrocytoma NOS 1 (2%)
Cerebrum, Astrocytoma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (57) (5) (58) (5) (58) (5)
Squamous Cell Carcinoma, Metastatic,
Uncertain Primary Site 1 (2%)
Nose (56) (5) (57) (5) (58) (5)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (5) (1)
Retrobulbar, Carcinoma 1 (20%)
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (57) (5) (58) (5) (58) (5)
Carcinoma, Metastatic, Pancreas 1 (2%)
Urinary Bladder (58) (58) (58)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(58) *(5) *(58) *(5) *(58) *(5)
Leukemia Mononuclear 25 (43%) 26 (45%) 34 (59%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 53 52
Total Primary Neoplasms 89 99 93
Total Animals with Benign Neoplasms 36 42 36
Total Benign Neoplasms 53 59 50
Total Animals with Malignant Neoplasms 35 34 38
Total Malignant Neoplasms 36 39 42
Total Animals with Metastatic Neoplasms 2 1
Total Metastatic Neoplasm 16 1
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1
Total Uncertain Neoplasms 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.5MG/M3 0.5MG/M3
LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 10
Scheduled Sacrifice 5 10
Early Deaths
Moribund Sacrifice 21
Accidently Killed 1
Natural Death 3
Survivors
Terminal Sacrifice 29
Missing 1
Animals Examined Microscopically 59 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (59)
Intestine Large, Cecum (58)
Intestine Small, Ileum (58)
Liver (59)
Mesentery (1)
Oral Mucosa (1)
Squamous Cell Carcinoma 1 (100%)
Pancreas (59)
Salivary Glands (59)
Stomach, Forestomach (58)
Stomach, Glandular (59)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (59)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (59)
Adrenal Medulla (59)
Pheochromocytoma Benign 3 (5%)
Islets, Pancreatic (59)
Parathyroid Gland (52)
Pituitary Gland (59)
Pars Distalis, Adenoma 22 (37%)
Thyroid Gland (57)
C-Cell, Adenoma 2 (4%)
Page 7
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.5MG/M3 0.5MG/M3
LUNG TOX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
C-Cell, Carcinoma 3 (5%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (5)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (59)
Adenoma 2 (3%)
Carcinoma 1 (2%)
Bilateral, Adenoma 1 (2%)
Ovary (59)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa-Theca Tumor Benign 1 (2%)
Uterus (59)
Polyp Stromal 7 (12%)
Sarcoma Stromal 1 (2%)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59)
Lymph Node (3)
Lymph Node, Bronchial (54) (5)
Lymph Node, Mandibular (54)
Lymph Node, Mesenteric (59)
Lymph Node, Mediastinal (52) (5)
Spleen (59)
Thymus (57)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59)
Adenocarcinoma 1 (2%)
Fibroadenoma 7 (12%)
Fibroadenoma, Multiple 2 (3%)
Skin (58)
Fibroma 1 (2%)
Pinna, Fibroma 1 (2%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.5MG/M3 0.5MG/M3
LUNG TOX
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (59)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (59) (5)
Alveolar/Bronchiolar Adenoma 1 (2%)
Nose (59) (5)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (5)
Urinary Bladder (59)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(59) *(5)
Leukemia Mononuclear 23 (39%)
Lymphoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 9
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.5MG/M3 0.5MG/M3
LUNG TOX
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48
Total Primary Neoplasms 83
Total Animals with Benign Neoplasms 36
Total Benign Neoplasms 50
Total Animals with Malignant Neoplasms 29
Total Malignant Neoplasms 33
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 10
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 59 11 58 12 58 12
Scheduled Sacrifice 5 11 5 12 5 12
Early Deaths
Moribund Sacrifice 34 30 31
Natural Death 4 7 3
Accidently Killed 1
Survivors
Terminal Sacrifice 16 16 18
Animals Examined Microscopically 59 5 58 5 58 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (59) (58) (58)
Intestine Large, Cecum (59) (58) (58)
Sarcoma 1 (2%)
Intestine Small, Duodenum (59) (58) (56)
Intestine Small, Jejunum (59) (57) (55)
Intestine Small, Ileum (59) (55) (53)
Liver (59) (58) (58)
Cholangiocarcinoma 1 (2%)
Hepatocellular Carcinoma 1 (2%) 1 (2%)
Hepatocellular Adenoma 1 (2%) 2 (3%)
Mesentery (2) (4)
Lipoma 2 (50%)
Schwannoma Benign 1 (50%)
Oral Mucosa (3) (2) (4)
Squamous Cell Carcinoma 3 (75%)
Squamous Cell Papilloma 2 (67%) 1 (50%) 1 (25%)
Pancreas (58) (57) (58)
Salivary Glands (59) (58) (57)
Stomach, Forestomach (59) (58) (57)
Stomach, Glandular (59) (58) (58)
Tongue (1)
Squamous Cell Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (59) (58) (58)
____________________________________________________________________________________________________________________________________
Page 11
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (59) (58) (58)
Adenoma 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Adrenal Medulla (59) (58) (58)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant 3 (5%) 2 (3%)
Pheochromocytoma Benign 11 (19%) 10 (17%) 12 (21%)
Bilateral, Pheochromocytoma Benign 5 (8%) 6 (10%)
Islets, Pancreatic (57) (56) (57)
Adenoma 2 (4%) 2 (4%) 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (59) (56) (58)
Pars Distalis, Adenoma 15 (25%) 12 (21%) 18 (31%)
Thyroid Gland (58) (58) (56)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 7 (12%) 1 (2%) 2 (4%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (4) (1) (5)
Cholangiocarcinoma, Metastatic, Liver 1 (25%)
Fibroma 1 (20%)
Paraganglioma 1 (25%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (59) (58) (58)
Preputial Gland (59) (58) (57)
Adenoma 2 (3%) 3 (5%)
Carcinoma 1 (2%) 3 (5%) 1 (2%)
Prostate (59) (57) (58)
Seminal Vesicle (59) (58) (58)
Testes (59) (58) (58)
Bilateral, Interstitial Cell, Adenoma 37 (63%) 43 (74%) 43 (74%)
Interstitial Cell, Adenoma 13 (22%) 8 (14%) 7 (12%)
____________________________________________________________________________________________________________________________________
Page 12
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (57) (57)
Osteosarcoma, Metastatic, Bone 1 (2%)
Lymph Node (11) (14) (11)
Lymph Node, Bronchial (56) (5) (54) (5) (52) (5)
Carcinoma, Metastatic, Preputial Gland 1 (2%)
Lymph Node, Mandibular (55) (57) (56)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 2 (4%)
Lymph Node, Mesenteric (59) (58) (58)
Hemangioma 1 (2%)
Lymph Node, Mediastinal (56) (3) (52) (5) (51) (4)
Spleen (59) (58) (56)
Hemangiosarcoma 1 (2%)
Thymus (54) (53) (53) (1)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (53) (53)
Adenocarcinoma 1 (2%) 1 (2%)
Fibroadenoma 1 (2%)
Fibroadenoma, Multiple 1 (2%)
Skin (58) (58) (58)
Fibroma 1 (2%)
Keratoacanthoma 5 (9%) 1 (2%) 1 (2%)
Lipoma 1 (2%) 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 2 (3%)
Lip, Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (59) (58) (58)
Humerus, Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (59) (58) (58) (1)
Glioma NOS 1 (2%)
Oligodendroglioma NOS 1 (100%)
____________________________________________________________________________________________________________________________________
Page 13
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (59) (57) (58)
Lung (59) (5) (58) (5) (58) (5)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Nose (59) (5) (57) (5) (58) (5)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (2)
Carcinoma 1 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (5) (57) (5) (57) (5)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (59) (58) (3) (58) (1)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(59) *(5) *(58) *(5) *(58) *(5)
Leukemia Mononuclear 31 (53%) 36 (62%) 39 (67%)
Lymphoma Malignant 1 (2%)
Mesothelioma Malignant 1 (2%)
Mesothelioma NOS 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 14
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.0MG/M3 0.0MG/M3 0.12 0.12MGM3 0.25 0.25MGM3
LUNG TOX MG/M3 LUNG TOX MG/M3 LUNG TOX
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 58 57 56 1
Total Primary Neoplasms 144 142 148 1
Total Animals with Benign Neoplasms 54 55 55
Total Benign Neoplasms 104 91 97
Total Animals with Malignant Neoplasms 37 43 42
Total Malignant Neoplasms 39 50 51
Total Animals with Metastatic Neoplasms 2 3 3
Total Metastatic Neoplasm 6 3 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 1 1
Total Uncertain Neoplasms 1 1 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 15
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.5MG/M3 0.5MG/M3
LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 58 12
Scheduled Sacrifice 5 12
Early Deaths
Moribund Sacrifice 28
Natural Death 4
Survivors
Terminal Sacrifice 20
Moribund Sacrifice 1
Animals Examined Microscopically 58 5
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (57)
Intestine Large, Cecum (57)
Intestine Small, Duodenum (58)
Intestine Small, Jejunum (58)
Intestine Small, Ileum (58)
Liver (58)
Hepatocellular Adenoma 2 (3%)
Mesentery (1)
Pancreas (58)
Salivary Glands (58)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (58)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (58)
Adrenal Medulla (58)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 9 (16%)
Bilateral, Pheochromocytoma Benign 2 (3%)
Islets, Pancreatic (58)
Adenoma 4 (7%)
Carcinoma 1 (2%)
Parathyroid Gland (53)
Adenoma 1 (2%)
Pituitary Gland (58)
Page 16
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.5MG/M3 0.5MG/M3
LUNG TOX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pars Distalis, Adenoma 14 (24%)
Thyroid Gland (57)
C-Cell, Adenoma 1 (2%)
C-Cell, Carcinoma 2 (4%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (4)
Paraganglioma 1 (25%)
Abdominal, Chondrosarcoma 1 (25%)
Thoracic, Chordoma 1 (25%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (58)
Adenoma 3 (5%)
Carcinoma 1 (2%)
Prostate (58)
Testes (58)
Bilateral, Interstitial Cell, Adenoma 43 (74%)
Interstitial Cell, Adenoma 11 (19%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (58)
Lymph Node (12)
Lymph Node, Bronchial (56) (5)
Lymph Node, Mandibular (57)
Lymph Node, Mesenteric (58)
Lymph Node, Mediastinal (54) (4)
Spleen (58)
Thymus (50)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49)
Fibroadenoma 1 (2%)
Skin (58)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 1 (2%)
Fibroma 3 (5%)
Squamous Cell Papilloma 2 (3%)
Page 17
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.5MG/M3 0.5MG/M3
LUNG TOX
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Subcutaneous Tissue, Osteosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (58)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (58) (5)
Alveolar/Bronchiolar Adenoma 2 (3%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Chordoma, Metastatic, Tissue NOS 1 (2%)
Nose (58) (5)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (58) (5)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (58) (2)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(58) *(5)
Leukemia Mononuclear 38 (66%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 18
NTP Experiment-Test: 05122-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 03:00:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.5MG/M3 0.5MG/M3
LUNG TOX
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 55
Total Primary Neoplasms 150
Total Animals with Benign Neoplasms 55
Total Benign Neoplasms 101
Total Animals with Malignant Neoplasms 41
Total Malignant Neoplasms 49
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 19
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