TDMS Study 05122-05 Pathology Tables
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 010101970
Lock Date: 02/03/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 6| 7| 7| 6| 5| 7| 7| 5| 7| 5| 4| 6| 6| 7| 6| 6| 6| 7| 4| 7| 7|
DAY ON TEST | 2| 7| 5| 2| 9| 3| 3| 5| 8| 3| 3| 0| 3| 3| 5| 4| 6| 3| 6| 9| 9| 3| 5| 3| 3|
| 9| 7| 9| 2| 1| 2| 1| 8| 9| 2| 0| 3| 1| 8| 9| 0| 6| 1| 3| 0| 6| 0| 9| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0.0MG/M3 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 4| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | I + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + + M + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 3 2 1 1 1 2 2 3 1 1 3 1 2 1 1 1 2 3 1 3 1 4 2|
Clear Cell Focus | 2 1 |
Degeneration, Cystic | 2 1 |
Degeneration, Fatty | 2 2 1 2 2 4 2 |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | X X |
Inflammation | 1 1 |
Mixed Cell Focus | 3 2 |
Thrombosis, Multiple | |
Bile Duct, Hyperplasia | 3 2 1 |
Centrilobular, Atrophy | 3 2 |
Hepatocyte, Necrosis | 3 2 3 2 1|
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia | |
Inflammation | 2 |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 6| 7| 7| 6| 5| 7| 7| 5| 7| 5| 4| 6| 6| 7| 6| 6| 6| 7| 4| 7| 7|
DAY ON TEST | 2| 7| 5| 2| 9| 3| 3| 5| 8| 3| 3| 0| 3| 3| 5| 4| 6| 3| 6| 9| 9| 3| 5| 3| 3|
| 9| 7| 9| 2| 1| 2| 1| 8| 9| 2| 0| 3| 1| 8| 9| 0| 6| 1| 3| 0| 6| 0| 9| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0.0MG/M3 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 4| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 2 2 4 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Congestion | |
Cyst | X |
Degeneration | 2 |
Hyperplasia | 1 1 |
Pigmentation, Hemosiderin | |
Vacuolization Cytoplasmic | 3 1 4 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia | 2 1 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X |
Pars Distalis, Hyperplasia, Diffuse | 3 2 |
Pars Distalis, Hyperplasia, Focal | 2 1 2 2 1 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
C-Cell, Hyperplasia | 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + + + |
Inflammation, Granulomatous | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 1 1 |
Hyperplasia | |
Hyperplasia, Squamous | |
Inflammation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Fibrosis | |
Endometrium, Hyperplasia | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 6| 7| 7| 6| 5| 7| 7| 5| 7| 5| 4| 6| 6| 7| 6| 6| 6| 7| 4| 7| 7|
DAY ON TEST | 2| 7| 5| 2| 9| 3| 3| 5| 8| 3| 3| 0| 3| 3| 5| 4| 6| 3| 6| 9| 9| 3| 5| 3| 3|
| 9| 7| 9| 2| 1| 2| 1| 8| 9| 2| 0| 3| 1| 8| 9| 0| 6| 1| 3| 0| 6| 0| 9| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0.0MG/M3 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 4| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Myeloid Cell, Hyperplasia | 1 4 3|
__________________________________________________________________________|
Lymph Node | + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Inflammation, Granulomatous | 1 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Infarct | |
Inflammation, Granulomatous | 3 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + I + + + + + + + + + + + + + + +|
Autolysis | |
Congestion | |
Hyperplasia, Lymphoid | |
Inflammation, Granulomatous | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Fibrosis | |
Hematopoietic Cell Proliferation | |
Hyperplasia, Histiocytic | 2 |
Infarct | |
Metaplasia, Osseous | |
Necrosis | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + I + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 1 3 3 3 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation | |
Dermis, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 1|
Ligament, Intervertebral Disc, | |
Degeneration | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 6| 7| 7| 6| 5| 7| 7| 5| 7| 5| 4| 6| 6| 7| 6| 6| 6| 7| 4| 7| 7|
DAY ON TEST | 2| 7| 5| 2| 9| 3| 3| 5| 8| 3| 3| 0| 3| 3| 5| 4| 6| 3| 6| 9| 9| 3| 5| 3| 3|
| 9| 7| 9| 2| 1| 2| 1| 8| 9| 2| 0| 3| 1| 8| 9| 0| 6| 1| 3| 0| 6| 0| 9| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0.0MG/M3 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 4| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 1 3 2 1 3 |
Meninges, Inflammation | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + I + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | 1 1 4|
Hyperplasia, Macrophage | 1 1 1 |
Inflammation, Chronic Active | 1 1 2 1 1 1 1 1 2|
Inflammation, Granulomatous | 2 |
Inflammation, Suppurative | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 2 2 |
Alveolus, Proteinosis | |
Interstitium, Infiltration Cellular | 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 1 |
Thrombosis, Multiple | X |
Nasolacrimal Duct, Ectasia | |
Nasolacrimal Duct, Inflammation | 1 |
Olfactory Epithelium, Degeneration | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Olfactory Epithelium, Inflammation | |
Olfactory Epithelium, Metaplasia | |
Olfactory Epithelium, Metaplasia, | |
Squamous | 2 |
Respiratory Epithelium, Degeneration | 1 1 1 1 1 |
Respiratory Epithelium, Hyperplasia | 2 1 |
Respiratory Epithelium, Inflammation | 2 1 1 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
Vomeronasal Organ, Inflammation | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Anterior Chamber, Inflammation | 1 |
Posterior Chamber, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 6| 4| 6| 6| 7| 7| 6| 5| 7| 7| 5| 7| 5| 4| 6| 6| 7| 6| 6| 6| 7| 4| 7| 7|
DAY ON TEST | 2| 7| 5| 2| 9| 3| 3| 5| 8| 3| 3| 0| 3| 3| 5| 4| 6| 3| 6| 9| 9| 3| 5| 3| 3|
| 9| 7| 9| 2| 1| 2| 1| 8| 9| 2| 0| 3| 1| 8| 9| 0| 6| 1| 3| 0| 6| 0| 9| 2| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0.0MG/M3 | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
| 4| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Autolysis | |
Congestion | |
Inflammation, Granulomatous | 2 |
Nephropathy | 2 2 1 2 1 2 2 2 1 1 1 2 1 2 1 2 2 1 2 1|
Pelvis, Dilatation | 3 |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 4 |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 6| 4| 7| 6| 6| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 7| 4|
DAY ON TEST | 2| 3| 1| 4| 5| 4| 5| 2| 4| 6| 2| 4| 3| 8| 2| 3| 3| 9| 8| 3| 3| 8| 8| 3| 4|
| 1| 2| 4| 3| 9| 3| 9| 7| 3| 9| 9| 3| 2| 6| 1| 2| 2| 2| 4| 6| 0| 3| 8| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + A|
Hyperplasia, Lymphoid | |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + A|
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
Peyer's Patch, Hyperplasia | 3 1 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + A|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + A|
Angiectasis | 1 |
Basophilic Focus | 3 3 2 1 1 1 2 2 3 1 2 3 4 1 1 2 2 2 2 3 |
Clear Cell Focus | |
Degeneration, Cystic | 1 |
Degeneration, Fatty | 1 1 2 2 2 2 3 |
Eosinophilic Focus | 2 3 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation | 1 3 |
Mixed Cell Focus | 1 |
Thrombosis, Multiple | X |
Bile Duct, Hyperplasia | 3 2 3 3 2 2 |
Centrilobular, Atrophy | |
Hepatocyte, Necrosis | 2 2 2 4 2 1 1 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Oral Mucosa | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation, Granulomatous | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hyperkeratosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
Erosion | 3 |
Hyperplasia | |
Inflammation | |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 6| 4| 7| 6| 6| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 7| 4|
DAY ON TEST | 2| 3| 1| 4| 5| 4| 5| 2| 4| 6| 2| 4| 3| 8| 2| 3| 3| 9| 8| 3| 3| 8| 8| 3| 4|
| 1| 2| 4| 3| 9| 3| 9| 7| 3| 9| 9| 3| 2| 6| 1| 2| 2| 2| 4| 6| 0| 3| 8| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 1 2 2 1 4 |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + A|
Autolysis | 3 |
Congestion | 2 3 |
Cyst | |
Degeneration | |
Hyperplasia | 2 1 3 |
Pigmentation, Hemosiderin | 2 |
Vacuolization Cytoplasmic | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + A|
Angiectasis | |
Hyperplasia | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
Angiectasis | 3 3 |
Cyst | X X X |
Pars Distalis, Hyperplasia, Diffuse | 2 4 |
Pars Distalis, Hyperplasia, Focal | 3 2 3 4 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
Fibrosis | |
C-Cell, Hyperplasia | 2 1 2 2 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Inflammation, Granulomatous | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + A|
Ectasia | 2 |
Hyperplasia | 4 |
Hyperplasia, Squamous | |
Inflammation | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + A|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + A|
Endometrium, Fibrosis | 3 1 |
Endometrium, Hyperplasia | 3 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 6| 4| 7| 6| 6| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 7| 4|
DAY ON TEST | 2| 3| 1| 4| 5| 4| 5| 2| 4| 6| 2| 4| 3| 8| 2| 3| 3| 9| 8| 3| 3| 8| 8| 3| 4|
| 1| 2| 4| 3| 9| 3| 9| 7| 3| 9| 9| 3| 2| 6| 1| 2| 2| 2| 4| 6| 0| 3| 8| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + A|
Atrophy | 3 |
Myeloid Cell, Hyperplasia | 1 2 3 1 3 |
__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + + + + + + + + + + + + + + + + + + M|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hyperplasia, Lymphoid | 3 3 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + A|
Congestion | 4 |
Infarct | 4 |
Inflammation, Granulomatous | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + I + + + + + + + + + + + + + M + + + + + + + + A|
Autolysis | 3 |
Congestion | 1 3 |
Hyperplasia, Lymphoid | 3 |
Inflammation, Granulomatous | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A|
Atrophy | |
Fibrosis | 3 2 3 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Histiocytic | |
Infarct | 3 |
Metaplasia, Osseous | 3 |
Necrosis | |
__________________________________________________________________________|
Thymus | M + M + + + + + + + + + + + A + + + + + + + + + A|
Atrophy | 3 2 2 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Inflammation | 2 |
Dermis, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 2 |
Ligament, Intervertebral Disc, | |
Degeneration | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 6| 4| 7| 6| 6| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 7| 4|
DAY ON TEST | 2| 3| 1| 4| 5| 4| 5| 2| 4| 6| 2| 4| 3| 8| 2| 3| 3| 9| 8| 3| 3| 8| 8| 3| 4|
| 1| 2| 4| 3| 9| 3| 9| 7| 3| 9| 9| 3| 2| 6| 1| 2| 2| 2| 4| 6| 0| 3| 8| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + A|
Compression | 3 2 2 |
Meninges, Inflammation | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + A|
Inflammation | 2 1 2 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + A|
Congestion | 3 |
Fibrosis | 1 1 1 1 |
Hyperplasia, Macrophage | 3 1 4 1 1 1 |
Inflammation, Chronic Active | 1 1 3 1 |
Inflammation, Granulomatous | |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 2 |
Alveolus, Proteinosis | 1 |
Interstitium, Infiltration Cellular | 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + A + + + + + + + + + A|
Thrombosis | 1 1 |
Thrombosis, Multiple | |
Nasolacrimal Duct, Ectasia | |
Nasolacrimal Duct, Inflammation | 1 3 2 |
Olfactory Epithelium, Degeneration | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Olfactory Epithelium, Inflammation | 2 |
Olfactory Epithelium, Metaplasia | 1 |
Olfactory Epithelium, Metaplasia, | |
Squamous | |
Respiratory Epithelium, Degeneration | 1 1 1 1 1 1 1 1 |
Respiratory Epithelium, Hyperplasia | 1 1 1 1 3 |
Respiratory Epithelium, Inflammation | 1 1 1 1 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
Vomeronasal Organ, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Anterior Chamber, Inflammation | |
Posterior Chamber, Inflammation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + A|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 4| 6| 4| 7| 6| 6| 7| 6| 7| 6| 6| 7| 7| 6| 5| 5| 7| 6| 6| 7| 4|
DAY ON TEST | 2| 3| 1| 4| 5| 4| 5| 2| 4| 6| 2| 4| 3| 8| 2| 3| 3| 9| 8| 3| 3| 8| 8| 3| 4|
| 1| 2| 4| 3| 9| 3| 9| 7| 3| 9| 9| 3| 2| 6| 1| 2| 2| 2| 4| 6| 0| 3| 8| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Autolysis | 3 3 |
Congestion | 3 |
Inflammation, Granulomatous | |
Nephropathy | 2 2 1 3 1 2 1 2 2 2 1 1 1 3 3 2 3 1 |
Pelvis, Dilatation | |
Renal Tubule, Necrosis | 3 |
Renal Tubule, Pigmentation | 3 4 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 7| | |
DAY ON TEST | 4| 1| 3| 2| 3| 6| 3| 2| | |
| 2| 3| 2| 9| 2| 6| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 57 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 56 |
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 56 |
Hyperplasia, Lymphoid | | 1 1.0|
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 56 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 57 |
Peyer's Patch, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 54 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 57 |
Angiectasis | 1 | 3 1.3|
Basophilic Focus | 2 1 2 1 1 1 | 49 1.9|
Clear Cell Focus | 1 1 | 4 1.3|
Degeneration, Cystic | 2 | 4 1.5|
Degeneration, Fatty | 2 | 15 2.0|
Eosinophilic Focus | | 2 2.5|
Hepatodiaphragmatic Nodule | | 5 |
Inflammation | | 4 1.5|
Mixed Cell Focus | 1 | 4 1.8|
Thrombosis, Multiple | | 1 |
Bile Duct, Hyperplasia | 3 | 10 2.4|
Centrilobular, Atrophy | | 2 2.5|
Hepatocyte, Necrosis | 1 | 13 2.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | | 3 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 57 |
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 57 |
Hyperkeratosis | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 57 |
Erosion | | 1 3.0|
Hyperplasia | 2 | 1 2.0|
Inflammation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 7| | |
DAY ON TEST | 4| 1| 3| 2| 3| 6| 3| 2| | |
| 2| 3| 2| 9| 2| 6| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | + | 3 |
Peridontal Tissue, Inflammation | 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 58 |
Cardiomyopathy | 1 2 | 12 2.1|
Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 57 |
Autolysis | | 1 3.0|
Congestion | | 2 2.5|
Cyst | X | 2 |
Degeneration | | 1 2.0|
Hyperplasia | 1 1 | 7 1.4|
Pigmentation, Hemosiderin | | 1 2.0|
Vacuolization Cytoplasmic | 2 | 8 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 56 |
Angiectasis | | 1 2.0|
Hyperplasia | | 6 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 57 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + | 54 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 57 |
Angiectasis | 1 1 | 4 2.0|
Cyst | X | 5 |
Pars Distalis, Hyperplasia, Diffuse | | 4 2.8|
Pars Distalis, Hyperplasia, Focal | 3 | 14 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 57 |
Fibrosis | | 1 2.0|
C-Cell, Hyperplasia | 3 | 9 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 6 |
Inflammation, Granulomatous | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + | 56 |
Ectasia | | 4 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 7| | |
DAY ON TEST | 4| 1| 3| 2| 3| 6| 3| 2| | |
| 2| 3| 2| 9| 2| 6| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hyperplasia | 3 | 2 3.5|
Hyperplasia, Squamous | 4 | 1 4.0|
Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 57 |
Cyst | X X | 7 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 57 |
Endometrium, Fibrosis | | 2 2.0|
Endometrium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 57 |
Atrophy | | 2 3.5|
Myeloid Cell, Hyperplasia | | 8 2.3|
__________________________________________________________________________|____________|
Lymph Node | + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + + + | 54 |
Hyperplasia, Lymphoid | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + | 57 |
Hyperplasia, Lymphoid | 2 3 | 5 2.6|
Inflammation, Granulomatous | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 57 |
Congestion | | 2 4.0|
Infarct | | 1 4.0|
Inflammation, Granulomatous | | 1 3.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + + + + + + | 53 |
Autolysis | | 1 3.0|
Congestion | 2 | 3 2.0|
Hyperplasia, Lymphoid | 2 | 2 2.5|
Inflammation, Granulomatous | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 57 |
Atrophy | 1 | 1 1.0|
Fibrosis | | 3 2.7|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia, Histiocytic | | 1 2.0|
Infarct | | 1 3.0|
Metaplasia, Osseous | | 1 3.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 7| | |
DAY ON TEST | 4| 1| 3| 2| 3| 6| 3| 2| | |
| 2| 3| 2| 9| 2| 6| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Atrophy | | 14 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 58 |
Cyst Epithelial Inclusion | | 1 |
Inflammation | | 1 2.0|
Dermis, Edema | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 58 |
Hyperostosis | | 4 2.8|
Ligament, Intervertebral Disc, | | |
Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 57 |
Compression | 2 | 9 2.1|
Meninges, Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + | 56 |
Inflammation | 1 1 | 9 1.3|
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 57 |
Congestion | | 1 3.0|
Fibrosis | 1 | 8 1.4|
Hyperplasia, Macrophage | 1 | 10 1.5|
Inflammation, Chronic Active | 2 1 1 | 16 1.3|
Inflammation, Granulomatous | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 6 1.5|
Alveolus, Proteinosis | | 1 1.0|
Interstitium, Infiltration Cellular | 1 1 1 | 14 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 56 |
Thrombosis | 1 | 4 1.0|
Thrombosis, Multiple | | 1 |
Nasolacrimal Duct, Ectasia | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation | 1 | 5 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 7| 7| 5| 7| 7| | |
DAY ON TEST | 4| 1| 3| 2| 3| 6| 3| 2| | |
| 2| 3| 2| 9| 2| 6| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Olfactory Epithelium, Degeneration | 1 1 1 1 1 1 1 | 45 1.0|
Olfactory Epithelium, Inflammation | | 1 2.0|
Olfactory Epithelium, Metaplasia | | 1 1.0|
Olfactory Epithelium, Metaplasia, | | |
Squamous | | 1 2.0|
Respiratory Epithelium, Degeneration | 1 | 14 1.0|
Respiratory Epithelium, Hyperplasia | 1 1 | 9 1.3|
Respiratory Epithelium, Inflammation | 1 1 1 1 | 13 1.2|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
Vomeronasal Organ, Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Anterior Chamber, Inflammation | | 1 1.0|
Posterior Chamber, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 57 |
Autolysis | | 2 3.0|
Congestion | | 1 3.0|
Inflammation, Granulomatous | | 1 2.0|
Nephropathy | 2 2 2 3 2 | 43 1.7|
Pelvis, Dilatation | | 1 3.0|
Renal Tubule, Necrosis | | 1 3.0|
Renal Tubule, Pigmentation | | 3 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 58 |
Inflammation, Granulomatous | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | A |
0.0MG/M3 | 7| 7| 7| 7| 7| 8| 8| 8| 9| 0| 1| 1| | L |
LUNG TOX | 1| 2| 3| 5| 8| 3| 5| 9| 1| 6| 7| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + | 5 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + I | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Interstitium, Infiltration Cellular | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
Olfactory Epithelium, Degeneration | 1 1 | 2 1.0|
Respiratory Epithelium, Degeneration | 1 | 1 1.0|
Respiratory Epithelium, Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | A |
0.0MG/M3 | 7| 7| 7| 7| 7| 8| 8| 8| 9| 0| 1| 1| | L |
LUNG TOX | 1| 2| 3| 5| 8| 3| 5| 9| 1| 6| 7| 9| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 4| 7| 2| 2| 4| 3| 9| 5| 7| 2| 5| 3| 3| 2| 3| 3| 5| 3| 5| 2| 3| 8| 5| 0| 2|
| 4| 8| 9| 7| 3| 2| 2| 6| 6| 9| 9| 1| 2| 9| 6| 2| 9| 1| 7| 5| 0| 0| 8| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
MG/M3 | 1| 3| 5| 6| 7| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + I + + + + + + I + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Basophilic Focus | 2 2 3 1 1 4 1 1 2 3 1 2 4 4 1 3 1 1 3 2 2 2 2|
Clear Cell Focus | 1 |
Degeneration, Cystic | 2 1 |
Degeneration, Fatty | 4 2 4 2 3 2 1 3 |
Eosinophilic Focus | 1 1 1 |
Hepatodiaphragmatic Nodule | X X|
Mixed Cell Focus | 1 |
Bile Duct, Hyperplasia | 2 3 2 2 2 4 4 |
Centrilobular, Atrophy | 2 3 2 |
Hepatocyte, Necrosis | 1 2 2 2 1 2 2 |
__________________________________________________________________________|
Mesentery | + |
Hemorrhage | |
__________________________________________________________________________|
Oral Mucosa | +|
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Submandibular Gland, | |
Hyperplasia | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 |
Inflammation | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
__________________________________________________________________________|
Tongue | |
Inflammation | |
__________________________________________________________________________|
Tooth | |
Epithelium Alveolus, Hyperplasia, | |
Squamous | |
Peridontal Tissue, Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 4| 7| 2| 2| 4| 3| 9| 5| 7| 2| 5| 3| 3| 2| 3| 3| 5| 3| 5| 2| 3| 8| 5| 0| 2|
| 4| 8| 9| 7| 3| 2| 2| 6| 6| 9| 9| 1| 2| 9| 6| 2| 9| 1| 7| 5| 0| 0| 8| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
MG/M3 | 1| 3| 5| 6| 7| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 1 1 1 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 1 1|
Vacuolization Cytoplasmic | 3 2 1 1 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia | 3 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | X |
Pars Distalis, Hyperplasia, Diffuse | |
Pars Distalis, Hyperplasia, Focal | 3 4 1 4 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 1 1 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Abdominal, Polyarteritis | |
Mediastinum, Inflammation | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 2 2 2 |
Hyperplasia | 4|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 1 |
Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Endometrium, Hyperplasia | 2 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 4 |
Autolysis | |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 4| 7| 2| 2| 4| 3| 9| 5| 7| 2| 5| 3| 3| 2| 3| 3| 5| 3| 5| 2| 3| 8| 5| 0| 2|
| 4| 8| 9| 7| 3| 2| 2| 6| 6| 9| 9| 1| 2| 9| 6| 2| 9| 1| 7| 5| 0| 0| 8| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
MG/M3 | 1| 3| 5| 6| 7| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Reticulum Cell | 3 |
Myeloid Cell, Hyperplasia | 3 2 3 2 2 3 |
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | 3 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Congestion | 3 1 |
Edema | |
Hyperplasia, Histiocytic | |
Inflammation | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + I + M + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Congestion | 2 4 |
Hyperplasia, Histiocytic | 4 |
Hyperplasia, Lymphoid | 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + A + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + A + +|
Atrophy | 1 2 1 4 2 3 2 3 2 4 2 3 |
Autolysis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Hyperplasia | 3 |
Duct, Ectasia | 2 2 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 4| 7| 2| 2| 4| 3| 9| 5| 7| 2| 5| 3| 3| 2| 3| 3| 5| 3| 5| 2| 3| 8| 5| 0| 2|
| 4| 8| 9| 7| 3| 2| 2| 6| 6| 9| 9| 1| 2| 9| 6| 2| 9| 1| 7| 5| 0| 0| 8| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
MG/M3 | 1| 3| 5| 6| 7| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 2 2 2 3 2 2 3|
Hemorrhage | 2 |
Ventricle, Hydrocephalus | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + I + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation | 1 1 2 1 1 2|
Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fibrosis | 1 1 3 |
Hemorrhage | 4 |
Hyperplasia, Macrophage | 1 1 1 1 2 |
Inflammation, Chronic Active | 1 1 1 1 1 2 1|
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 1 |
Interstitium, Infiltration Cellular | 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + A + +|
Thrombosis | 1 1 |
Nasolacrimal Duct, Inflammation | 2 2 2 |
Nasopharyngeal Duct, Hyperplasia | 2|
Nasopharyngeal Duct, Inflammation | 3|
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration | 1 1 1 1 1 1 1 1 1|
Respiratory Epithelium, Degeneration | 1 1 1 1 1 1 |
Respiratory Epithelium, Hyperplasia | 1 1 1 1 1 1 3 1 1 1|
Respiratory Epithelium, Inflammation | 1 1 1 3 2 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + + |
Inflammation | 4 |
Phthisis Bulbi | X |
Synechia | |
Anterior Chamber, Inflammation | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 6| 7| 5| 6| 6| 7| 4| 7| 7| 7| 6| 7| 5| 7| 6| 7| 7| 5| 6| 7| 7|
DAY ON TEST | 4| 7| 2| 2| 4| 3| 9| 5| 7| 2| 5| 3| 3| 2| 3| 3| 5| 3| 5| 2| 3| 8| 5| 0| 2|
| 4| 8| 9| 7| 3| 2| 2| 6| 6| 9| 9| 1| 2| 9| 6| 2| 9| 1| 7| 5| 0| 0| 8| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4|
MG/M3 | 1| 3| 5| 6| 7| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 3| 5| 6| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cyst | |
Nephropathy | 2 1 1 1 3 1 2 2 1 3 3 3 4 1 4 2 2 4 3 2 2|
Pelvis, Dilatation | 3 |
Renal Tubule, Pigmentation | 1 3 4 1 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 4| 6| 6| 7| 7| 6| 4| 4| 7| 5| 5| 5| 4| 6| 6| 6| 5| 7| 7| 5| 6| 6| 4| 3|
DAY ON TEST | 6| 5| 0| 0| 2| 3| 6| 5| 8| 2| 7| 3| 3| 5| 0| 4| 9| 9| 2| 3| 5| 8| 1| 5| 9|
| 4| 9| 5| 7| 9| 0| 4| 9| 9| 9| 3| 7| 7| 9| 0| 4| 1| 6| 9| 1| 9| 2| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
MG/M3 | 3| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 3 1 3 1 2 2 1 2 1 1 1 3 2 1 4 4 1 1|
Clear Cell Focus | |
Degeneration, Cystic | 2 1 |
Degeneration, Fatty | 3 3 3 |
Eosinophilic Focus | 1 |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 2 |
Centrilobular, Atrophy | 3 2 |
Hepatocyte, Necrosis | 2 1 |
__________________________________________________________________________|
Mesentery | + |
Hemorrhage | 3 |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Submandibular Gland, | |
Hyperplasia | 4 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Inflammation | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
__________________________________________________________________________|
Tongue | + |
Inflammation | 3 |
__________________________________________________________________________|
Tooth | + + |
Epithelium Alveolus, Hyperplasia, | |
Squamous | 3 |
Peridontal Tissue, Inflammation | 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 4| 6| 6| 7| 7| 6| 4| 4| 7| 5| 5| 5| 4| 6| 6| 6| 5| 7| 7| 5| 6| 6| 4| 3|
DAY ON TEST | 6| 5| 0| 0| 2| 3| 6| 5| 8| 2| 7| 3| 3| 5| 0| 4| 9| 9| 2| 3| 5| 8| 1| 5| 9|
| 4| 9| 5| 7| 9| 0| 4| 9| 9| 9| 3| 7| 7| 9| 0| 4| 1| 6| 9| 1| 9| 2| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
MG/M3 | 3| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Cardiomyopathy | 2 1 1 2 |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Vacuolization Cytoplasmic | 3 3 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + M + + + + + + I + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Cyst | X X |
Pars Distalis, Hyperplasia, Diffuse | 2 |
Pars Distalis, Hyperplasia, Focal | 4 2 3 2 2 3 4 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Abdominal, Polyarteritis | |
Mediastinum, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 3 |
Hyperplasia | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Endometrium, Hyperplasia | |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | |
Autolysis | |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 4| 6| 6| 7| 7| 6| 4| 4| 7| 5| 5| 5| 4| 6| 6| 6| 5| 7| 7| 5| 6| 6| 4| 3|
DAY ON TEST | 6| 5| 0| 0| 2| 3| 6| 5| 8| 2| 7| 3| 3| 5| 0| 4| 9| 9| 2| 3| 5| 8| 1| 5| 9|
| 4| 9| 5| 7| 9| 0| 4| 9| 9| 9| 3| 7| 7| 9| 0| 4| 1| 6| 9| 1| 9| 2| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
MG/M3 | 3| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Reticulum Cell | |
Myeloid Cell, Hyperplasia | 1 2 |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
Autolysis | |
Hyperplasia, Lymphoid | 1 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Congestion | |
Edema | 3 |
Hyperplasia, Histiocytic | 1 |
Inflammation | 2 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M I + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Congestion | 3 4 1 |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 4 |
Hemorrhage | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + I + + + + + + + + + +|
Atrophy | 2 3 3 2 2 1|
Autolysis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Hyperplasia | |
Duct, Ectasia | |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 4| 6| 6| 7| 7| 6| 4| 4| 7| 5| 5| 5| 4| 6| 6| 6| 5| 7| 7| 5| 6| 6| 4| 3|
DAY ON TEST | 6| 5| 0| 0| 2| 3| 6| 5| 8| 2| 7| 3| 3| 5| 0| 4| 9| 9| 2| 3| 5| 8| 1| 5| 9|
| 4| 9| 5| 7| 9| 0| 4| 9| 9| 9| 3| 7| 7| 9| 0| 4| 1| 6| 9| 1| 9| 2| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
MG/M3 | 3| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 1 2 3 |
Hemorrhage | 2 |
Ventricle, Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | 1 1 1 1 2 1 1|
Metaplasia, Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | 1 1 1 1 |
Hemorrhage | |
Hyperplasia, Macrophage | 1 1 1 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Interstitium, Infiltration Cellular | 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 1 |
Nasolacrimal Duct, Inflammation | 4 |
Nasopharyngeal Duct, Hyperplasia | |
Nasopharyngeal Duct, Inflammation | |
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Degeneration | 1 1 1 1 1 1 1 1 |
Respiratory Epithelium, Degeneration | 1 1 1 1 1 1 1 1 1 1 |
Respiratory Epithelium, Hyperplasia | 1 1 1 2 |
Respiratory Epithelium, Inflammation | 4 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Inflammation | |
Phthisis Bulbi | |
Synechia | 4 |
Anterior Chamber, Inflammation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 4| 6| 6| 7| 7| 6| 4| 4| 7| 5| 5| 5| 4| 6| 6| 6| 5| 7| 7| 5| 6| 6| 4| 3|
DAY ON TEST | 6| 5| 0| 0| 2| 3| 6| 5| 8| 2| 7| 3| 3| 5| 0| 4| 9| 9| 2| 3| 5| 8| 1| 5| 9|
| 4| 9| 5| 7| 9| 0| 4| 9| 9| 9| 3| 7| 7| 9| 0| 4| 1| 6| 9| 1| 9| 2| 9| 9| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.12 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|
MG/M3 | 3| 5| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Cyst | X |
Nephropathy | 1 1 2 1 1 2 1 1 1 1 2 2 4 1 2 3 1 |
Pelvis, Dilatation | |
Renal Tubule, Pigmentation | 4 1 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 7| 5| 5| 6| | |
DAY ON TEST | 4| 2| 3| 3| 3| 9| 5| 5| | |
| 4| 0| 0| 9| 0| 6| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.12 | 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/M3 | 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A | 55 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 56 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 58 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 58 |
Peyer's Patch, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A | 56 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 58 |
Angiectasis | 2 1 | 4 1.8|
Basophilic Focus | 2 3 1 1 1 | 46 2.0|
Clear Cell Focus | | 1 1.0|
Degeneration, Cystic | 1 | 5 1.4|
Degeneration, Fatty | 3 3 | 13 2.8|
Eosinophilic Focus | | 4 1.0|
Hepatodiaphragmatic Nodule | X | 5 |
Mixed Cell Focus | | 1 1.0|
Bile Duct, Hyperplasia | 2 2 2 | 11 2.5|
Centrilobular, Atrophy | | 5 2.4|
Hepatocyte, Necrosis | 2 2 | 11 1.7|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Hemorrhage | | 1 3.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 58 |
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 58 |
Duct, Submandibular Gland, | | |
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 58 |
Edema | | 1 4.0|
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 58 |
Erosion | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + + + | 5 |
Epithelium Alveolus, Hyperplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 7| 5| 5| 6| | |
DAY ON TEST | 4| 2| 3| 3| 3| 9| 5| 5| | |
| 4| 0| 0| 9| 0| 6| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.12 | 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/M3 | 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Squamous | | 1 3.0|
Peridontal Tissue, Inflammation | 2 1 1 | 5 1.4|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 58 |
Cardiomyopathy | 2 | 9 1.4|
Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 58 |
Hyperplasia | 1 | 6 1.3|
Vacuolization Cytoplasmic | | 8 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 57 |
Cyst | | 1 |
Hyperplasia | | 4 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 58 |
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 55 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 58 |
Angiectasis | 3 2 | 5 2.2|
Cyst | X | 4 |
Pars Distalis, Hyperplasia, Diffuse | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 4 4 | 16 3.1|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 58 |
C-Cell, Hyperplasia | | 7 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 4 |
Abdominal, Polyarteritis | X | 1 |
Mediastinum, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + | 57 |
Ectasia | 2 | 7 1.9|
Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 58 |
Atrophy | | 2 2.5|
Cyst | | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 7| 5| 5| 6| | |
DAY ON TEST | 4| 2| 3| 3| 3| 9| 5| 5| | |
| 4| 0| 0| 9| 0| 6| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.12 | 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/M3 | 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 58 |
Hemorrhage | | 1 4.0|
Endometrium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 58 |
Atrophy, Diffuse | | 1 4.0|
Autolysis | 2 | 1 2.0|
Hyperplasia | | 1 2.0|
Hyperplasia, Reticulum Cell | | 1 3.0|
Myeloid Cell, Hyperplasia | 2 2 | 10 2.2|
__________________________________________________________________________|____________|
Lymph Node | + + | 7 |
Iliac, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + | 57 |
Congestion | 3 | 4 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + | 57 |
Autolysis | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 3 2.3|
Hyperplasia, Plasma Cell | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 58 |
Autolysis | 2 | 1 2.0|
Congestion | | 2 2.0|
Edema | | 1 3.0|
Hyperplasia, Histiocytic | | 1 1.0|
Inflammation | | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + | 54 |
Autolysis | 2 | 2 2.0|
Congestion | 2 | 6 2.7|
Hyperplasia, Histiocytic | | 1 4.0|
Hyperplasia, Lymphoid | 2 | 4 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 57 |
Fibrosis | | 2 2.0|
Hematopoietic Cell Proliferation | | 1 4.0|
Hemorrhage | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 54 |
Atrophy | 2 | 19 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 7| 5| 5| 6| | |
DAY ON TEST | 4| 2| 3| 3| 3| 9| 5| 5| | |
| 4| 0| 0| 9| 0| 6| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.12 | 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/M3 | 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Autolysis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 58 |
Hyperplasia, Focal | | 1 1.0|
Hyperplasia | | 1 3.0|
Duct, Ectasia | | 2 2.0|
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 58 |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 58 |
Hyperostosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 58 |
Compression | 1 | 14 2.3|
Hemorrhage | | 2 2.0|
Ventricle, Hydrocephalus | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + | 57 |
Hyperplasia | | 1 1.0|
Inflammation | | 13 1.2|
Metaplasia, Squamous | | 1 1.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 58 |
Congestion | | 1 3.0|
Fibrosis | | 7 1.3|
Hemorrhage | | 1 4.0|
Hyperplasia, Macrophage | | 11 1.1|
Inflammation, Chronic Active | 2 | 13 1.2|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 3 1.7|
Interstitium, Infiltration Cellular | 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 57 |
Thrombosis | 1 | 4 1.0|
Nasolacrimal Duct, Inflammation | | 4 2.5|
Nasopharyngeal Duct, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 7| 5| 5| 6| | |
DAY ON TEST | 4| 2| 3| 3| 3| 9| 5| 5| | |
| 4| 0| 0| 9| 0| 6| 0| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.12 | 7| 7| 7| 7| 7| 7| 7| 8| | L |
MG/M3 | 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Nasopharyngeal Duct, Inflammation | | 1 3.0|
Olfactory Epithelium, Atrophy | | 1 1.0|
Olfactory Epithelium, Degeneration | 1 1 1 | 20 1.0|
Respiratory Epithelium, Degeneration | 1 | 17 1.0|
Respiratory Epithelium, Hyperplasia | 1 1 1 | 17 1.2|
Respiratory Epithelium, Inflammation | 1 | 8 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 58 |
Inflammation | | 1 2.0|
Epithelium, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 5 |
Inflammation | | 1 4.0|
Phthisis Bulbi | | 1 |
Synechia | | 1 4.0|
Anterior Chamber, Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 58 |
Autolysis | | 1 3.0|
Cyst | | 1 |
Nephropathy | 2 1 3 | 41 2.0|
Pelvis, Dilatation | | 1 3.0|
Renal Tubule, Pigmentation | | 8 2.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 58 |
Inflammation | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.12MGM3 | 1| 1| 1| 2| 3| 3| 3| 4| 4| 5| 5| 6| | L |
LUNG TOX | 2| 4| 9| 4| 2| 4| 7| 4| 6| 5| 8| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + | 5 |
Hyperplasia, Lymphoid | 2 2 1 1 | 4 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 5 |
Hyperplasia, Lymphoid | 2 1 | 2 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Hyperplasia, Macrophage | 1 1 | 2 1.0|
Inflammation, Chronic Active | 1 1 | 2 1.0|
Interstitium, Infiltration Cellular | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
Olfactory Epithelium, Degeneration | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.12MGM3 | 1| 1| 1| 2| 3| 3| 3| 4| 4| 5| 5| 6| | L |
LUNG TOX | 2| 4| 9| 4| 2| 4| 7| 4| 6| 5| 8| 6| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 7| 6| 4| 0| 7| 6| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 6| 7| 4| 6| 6|
DAY ON TEST | 0| 0| 4| 0| 4| 3| 4| 1| 7| 3| 1| 3| 2| 5| 3| 6| 0| 2| 3| 2| 0| 3| 5| 5| 4|
| 5| 6| 7| 3| 0| 1| 2| 7| 5| 1| 0| 1| 9| 9| 0| 2| 0| 9| 0| 9| 8| 2| 9| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
MG/M3 | 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 2 3 2 1 3 1 1 4 1 2 2 4 3 1 1 |
Clear Cell Focus | |
Degeneration, Cystic | 1 |
Degeneration, Fatty | 1 3 3 3 2 4 2 2 |
Eosinophilic Focus | |
Granuloma | |
Hepatodiaphragmatic Nodule | X X |
Mixed Cell Focus | 1 |
Bile Duct, Hyperplasia | 2 3 3 3 2 1 3 2 2 2|
Centrilobular, Atrophy | 1 2 2 2 |
Hepatocyte, Necrosis | 2 1 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Acinus, Atrophy | 2 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | 3 |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 7| 6| 4| 0| 7| 6| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 6| 7| 4| 6| 6|
DAY ON TEST | 0| 0| 4| 0| 4| 3| 4| 1| 7| 3| 1| 3| 2| 5| 3| 6| 0| 2| 3| 2| 0| 3| 5| 5| 4|
| 5| 6| 7| 3| 0| 1| 2| 7| 5| 1| 0| 1| 9| 9| 0| 2| 0| 9| 0| 9| 8| 2| 9| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
MG/M3 | 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hemorrhage | 4 |
Hyperplasia | 2 3 1 1 |
Hypertrophy | 3 |
Vacuolization Cytoplasmic | 1 4 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 1 4 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 4 2 |
Cyst | X |
Hemorrhage | 1 |
Pars Distalis, Hyperplasia, Diffuse | 3 4 3 |
Pars Distalis, Hyperplasia, Focal | 2 2 3 2 4 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
C-Cell, Hyperplasia | 1 2 3 2 3|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 |
Hyperplasia | |
Inflammation | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Endometrium, Hyperplasia | 4 |
__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2|
Hyperplasia | |
Myeloid Cell, Hyperplasia | 2 2 1 4 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + M + + + + + + + + + + + + I + +|
Congestion | |
Hyperplasia, Plasma Cell | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 7| 6| 4| 0| 7| 6| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 6| 7| 4| 6| 6|
DAY ON TEST | 0| 0| 4| 0| 4| 3| 4| 1| 7| 3| 1| 3| 2| 5| 3| 6| 0| 2| 3| 2| 0| 3| 5| 5| 4|
| 5| 6| 7| 3| 0| 1| 2| 7| 5| 1| 0| 1| 9| 9| 0| 2| 0| 9| 0| 9| 8| 2| 9| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
MG/M3 | 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Congestion | 4 |
Pigmentation, Hemosiderin | 1 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M M + + + + + + + M + + + I M + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Fibrosis | 3 2 1 3 |
Hyperplasia, Re Cell | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 1 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | |
Hyperostosis | 1 2 |
Tibia, Fracture | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 2 |
Compression | 2 |
Degeneration | 2 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation | 1 1 3 1 1 1 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fibrosis | 2 1 1 1 2 2 1 1 1 2 2 2 1 1 2 2 1 2 3|
Hyperplasia, Macrophage | 1 2 3 1 2 2 1 2 1 1 3 1 1 |
Inflammation, Chronic Active | 2 2 2 2 2 3 3 1 2 2 1 2 2 3 1 3 2 2 2 1 2 3|
Alveolar Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 7| 6| 4| 0| 7| 6| 6| 6| 7| 7| 7| 6| 4| 7| 6| 7| 7| 7| 7| 6| 7| 4| 6| 6|
DAY ON TEST | 0| 0| 4| 0| 4| 3| 4| 1| 7| 3| 1| 3| 2| 5| 3| 6| 0| 2| 3| 2| 0| 3| 5| 5| 4|
| 5| 6| 7| 3| 0| 1| 2| 7| 5| 1| 0| 1| 9| 9| 0| 2| 0| 9| 0| 9| 8| 2| 9| 5| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|
MG/M3 | 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Focal | 4 1 |
Alveolus, Proteinosis | 1 1 1 1 1 2 1 1 2 |
Interstitium, Infiltration Cellular | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 1 1 1 |
Nasolacrimal Duct, Inflammation | 1 |
Nasopharyngeal Duct, Hyperplasia | 2 |
Nasopharyngeal Duct, Inflammation | 1 |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration | 1 1 1 1 1 |
Olfactory Epithelium, Erosion | |
Olfactory Epithelium, Inflammation | 1 1 |
Olfactory Epithelium, Metaplasia | 2 |
Respiratory Epithelium, Degeneration | 1 1 1 1 |
Respiratory Epithelium, Erosion | |
Respiratory Epithelium, Hyperplasia | 3 1 3 1 1 |
Respiratory Epithelium, Inflammation | 3 2 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | |
Metaplasia, Squamous | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cornea, Fibrosis | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | |
Infarct | 2 |
Nephropathy | 1 2 3 3 1 2 2 1 2 1 1 1 2 1 2 1 1|
Pelvis, Dilatation | |
Renal Tubule, Degeneration | 3 |
Renal Tubule, Necrosis | 2 |
Renal Tubule, Pigmentation | 3 3 4 4 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 7| 4|
DAY ON TEST | 6| 6| 3| 3| 1| 1| 8| 6| 7| 4| 2| 3| 3| 2| 2| 5| 3| 1| 3| 3| 5| 3| 3| 3| 5|
| 1| 2| 2| 2| 1| 5| 3| 2| 5| 8| 9| 1| 1| 9| 9| 9| 0| 0| 1| 2| 9| 0| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
0.25 | 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1|
MG/M3 | 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 6| 7| 8| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + I + + + + + + + + I + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Peyer's Patch, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2|
Basophilic Focus | 1 2 1 1 1 2 1 1 2 4 1 3 3 2 4 1 2 2 4 3 1|
Clear Cell Focus | 1 |
Degeneration, Cystic | 1 1 1 1 |
Degeneration, Fatty | 3 3 1 1 |
Eosinophilic Focus | 2 |
Granuloma | 2 |
Hepatodiaphragmatic Nodule | X X X X |
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 3 2 2 1 |
Centrilobular, Atrophy | 2 |
Hepatocyte, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
Inflammation | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 7| 4|
DAY ON TEST | 6| 6| 3| 3| 1| 1| 8| 6| 7| 4| 2| 3| 3| 2| 2| 5| 3| 1| 3| 3| 5| 3| 3| 3| 5|
| 1| 2| 2| 2| 1| 5| 3| 2| 5| 8| 9| 1| 1| 9| 9| 9| 0| 0| 1| 2| 9| 0| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
0.25 | 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1|
MG/M3 | 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 6| 7| 8| 0|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hemorrhage | |
Hyperplasia | 1 |
Hypertrophy | |
Vacuolization Cytoplasmic | 1 1 1 1 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + I + + + + + + M + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | |
Hemorrhage | |
Pars Distalis, Hyperplasia, Diffuse | |
Pars Distalis, Hyperplasia, Focal | 4 3 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
C-Cell, Hyperplasia | 3 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hyperplasia | 4 |
Inflammation | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Endometrium, Hyperplasia | |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Hyperplasia | 2|
Myeloid Cell, Hyperplasia | 2 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + M + + + + + + + + + + + M|
Congestion | |
Hyperplasia, Plasma Cell | 1 |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 7| 4|
DAY ON TEST | 6| 6| 3| 3| 1| 1| 8| 6| 7| 4| 2| 3| 3| 2| 2| 5| 3| 1| 3| 3| 5| 3| 3| 3| 5|
| 1| 2| 2| 2| 1| 5| 3| 2| 5| 8| 9| 1| 1| 9| 9| 9| 0| 0| 1| 2| 9| 0| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
0.25 | 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1|
MG/M3 | 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 6| 7| 8| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M I + + + + + + + + +|
Hyperplasia, Lymphoid | 3 1 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Congestion | |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + I M I + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Fibrosis | 2 |
Hyperplasia, Re Cell | |
__________________________________________________________________________|
Thymus | I + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fracture | X |
Hyperostosis | |
Tibia, Fracture | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Compression | 4 2 1 2 |
Degeneration | |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hyperplasia | |
Inflammation | 1 2 1 1 1 1 1 3 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | 1 2 3 2 2 2 1 1 3 2 2 2 2 2 1 2 2 1 1 2 |
Hyperplasia, Macrophage | 2 2 1 1 2 1 2 1 2 1 1 1 1 2 2 2|
Inflammation, Chronic Active | 3 2 3 3 3 1 1 2 3 2 3 2 2 3 1 2 2 1 1 2 3 1|
Alveolar Epithelium, Hyperplasia, | |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 7| 7| 7| 7| 4| 7| 5| 7| 7| 4| 7| 7| 7| 4|
DAY ON TEST | 6| 6| 3| 3| 1| 1| 8| 6| 7| 4| 2| 3| 3| 2| 2| 5| 3| 1| 3| 3| 5| 3| 3| 3| 5|
| 1| 2| 2| 2| 1| 5| 3| 2| 5| 8| 9| 1| 1| 9| 9| 9| 0| 0| 1| 2| 9| 0| 1| 1| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
0.25 | 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1|
MG/M3 | 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 6| 7| 8| 0|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Focal | 3 2 2 |
Alveolus, Proteinosis | 2 2 1 2 2 1 1 1 2 2|
Interstitium, Infiltration Cellular | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 1 1 |
Nasolacrimal Duct, Inflammation | |
Nasopharyngeal Duct, Hyperplasia | |
Nasopharyngeal Duct, Inflammation | |
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration | 1 1 1 1 |
Olfactory Epithelium, Erosion | 2 |
Olfactory Epithelium, Inflammation | 1 |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Degeneration | 1 |
Respiratory Epithelium, Erosion | 2 |
Respiratory Epithelium, Hyperplasia | 1 1 2 1 1 1 2 1 1 |
Respiratory Epithelium, Inflammation | 1 1 1 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation | 1 |
Metaplasia, Squamous | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cornea, Fibrosis | 2 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Fatty | |
Infarct | |
Nephropathy | 2 2 3 2 1 2 1 1 1 1 2 1 3 3 3 4 2 |
Pelvis, Dilatation | |
Renal Tubule, Degeneration | |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 2| 9| 3| 3| 3| | |
| 1| 1| 2| 0| 9| 7| 0| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.25 | 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + I + I + + + + + | 53 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 58 |
Autolysis | | 1 4.0|
Peyer's Patch, Hyperplasia | 3 3 | 3 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 57 |
Autolysis | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 58 |
Angiectasis | | 2 1.5|
Basophilic Focus | 1 4 2 3 1 1 2 3 | 45 2.0|
Clear Cell Focus | 3 | 2 2.0|
Degeneration, Cystic | | 5 1.0|
Degeneration, Fatty | 1 4 | 14 2.4|
Eosinophilic Focus | 1 | 2 1.5|
Granuloma | 3 | 2 2.5|
Hepatodiaphragmatic Nodule | | 6 |
Mixed Cell Focus | | 1 1.0|
Bile Duct, Hyperplasia | 3 2 | 16 2.3|
Centrilobular, Atrophy | 2 2 | 7 1.9|
Hepatocyte, Necrosis | | 3 1.7|
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Oral Mucosa | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 58 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Acinus, Atrophy | 2 | 4 2.3|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 58 |
Hyperplasia | | 1 4.0|
Inflammation | | 1 3.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 58 |
Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 2| 9| 3| 3| 3| | |
| 1| 1| 2| 0| 9| 7| 0| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.25 | 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Cardiomyopathy | 2 2 2 | 8 2.0|
Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + | 58 |
Hemorrhage | | 1 4.0|
Hyperplasia | | 5 1.6|
Hypertrophy | | 1 3.0|
Vacuolization Cytoplasmic | | 7 1.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + | 58 |
Hyperplasia | | 8 1.8|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + | 55 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 58 |
Angiectasis | 4 | 5 3.0|
Cyst | | 1 |
Hemorrhage | 3 | 2 2.0|
Pars Distalis, Hyperplasia, Diffuse | | 3 3.3|
Pars Distalis, Hyperplasia, Focal | 2 | 12 2.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 58 |
Autolysis | | 1 3.0|
C-Cell, Hyperplasia | | 7 2.3|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + M + + + | 57 |
Ectasia | | 2 3.0|
Hyperplasia | | 1 4.0|
Inflammation | | 2 3.5|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 58 |
Cyst | X | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 58 |
Hemorrhage | | 1 3.0|
Endometrium, Hyperplasia | 3 | 2 3.5|
__________________________________________________________________________|____________|
Vagina | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 2| 9| 3| 3| 3| | |
| 1| 1| 2| 0| 9| 7| 0| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.25 | 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 58 |
Atrophy, Focal | | 1 2.0|
Hyperplasia | | 1 2.0|
Myeloid Cell, Hyperplasia | 3 | 10 2.5|
__________________________________________________________________________|____________|
Lymph Node | | 11 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + | 54 |
Congestion | 3 2 | 2 2.5|
Hyperplasia, Plasma Cell | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + | 56 |
Hyperplasia, Lymphoid | 3 | 5 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 58 |
Autolysis | | 1 2.0|
Congestion | 3 | 2 3.5|
Pigmentation, Hemosiderin | | 3 1.7|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M M + + | 48 |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 58 |
Angiectasis | | 1 3.0|
Fibrosis | 2 | 6 2.2|
Hyperplasia, Re Cell | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + | 56 |
Atrophy | 4 2 4 | 13 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 58 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 58 |
Fracture | | 1 |
Hyperostosis | | 2 1.5|
Tibia, Fracture | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 2| 9| 3| 3| 3| | |
| 1| 1| 2| 0| 9| 7| 0| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.25 | 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Autolysis | | 1 2.0|
Compression | | 5 2.2|
Degeneration | | 1 2.0|
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + | 57 |
Hyperplasia | | 1 2.0|
Inflammation | 1 1 1 | 21 1.2|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 58 |
Congestion | | 1 3.0|
Fibrosis | 1 2 2 1 1 3 1 | 46 1.7|
Hyperplasia, Macrophage | 1 1 1 2 2 1 | 35 1.5|
Inflammation, Chronic Active | 2 1 2 2 2 2 2 3 2 | 53 2.1|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 4 | 7 2.6|
Alveolus, Proteinosis | 1 2 2 2 1 1 | 25 1.4|
Interstitium, Infiltration Cellular | 2 | 4 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 58 |
Thrombosis | | 5 1.0|
Nasolacrimal Duct, Inflammation | | 1 1.0|
Nasopharyngeal Duct, Hyperplasia | | 1 2.0|
Nasopharyngeal Duct, Inflammation | | 1 1.0|
Olfactory Epithelium, Atrophy | 1 | 1 1.0|
Olfactory Epithelium, Degeneration | 1 1 | 11 1.0|
Olfactory Epithelium, Erosion | | 1 2.0|
Olfactory Epithelium, Inflammation | | 3 1.0|
Olfactory Epithelium, Metaplasia | | 1 2.0|
Respiratory Epithelium, Degeneration | | 5 1.0|
Respiratory Epithelium, Erosion | | 1 2.0|
Respiratory Epithelium, Hyperplasia | 2 1 1 | 17 1.4|
Respiratory Epithelium, Inflammation | 1 1 | 12 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 58 |
Hyperplasia | | 1 1.0|
Inflammation | | 1 1.0|
Metaplasia, Squamous | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 3| 2| 9| 3| 3| 3| | |
| 1| 1| 2| 0| 9| 7| 0| 2| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
0.25 | 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
Cornea, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 58 |
Degeneration, Fatty | 2 | 1 2.0|
Infarct | | 1 2.0|
Nephropathy | 1 1 1 3 1 2 2 | 41 1.8|
Pelvis, Dilatation | 2 1 | 2 1.5|
Renal Tubule, Degeneration | | 1 3.0|
Renal Tubule, Necrosis | | 1 2.0|
Renal Tubule, Pigmentation | 4 | 8 2.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| | A |
0.25MGM3 | 5| 5| 6| 8| 8| 9| 9| 0| 0| 0| 1| | L |
LUNG TOX | 3| 5| 3| 0| 9| 1| 2| 3| 4| 9| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + | 4 |
Hyperplasia, Lymphoid | 1 1 1 1 | 4 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 5 |
Hyperplasia, Lymphoid | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Hyperplasia, Macrophage | 1 1 1 1 | 4 1.0|
Inflammation, Chronic Active | 2 1 1 1 | 4 1.3|
Interstitium, Infiltration Cellular | 2 1 1 1 1 | 5 1.2|
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| | A |
0.25MGM3 | 5| 5| 6| 8| 8| 9| 9| 0| 0| 0| 1| | L |
LUNG TOX | 3| 5| 3| 0| 9| 1| 2| 3| 4| 9| 9| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 4| 6| 6| 4| 3| 7| 2| 4| 4| 6| 7| 6| 5| 7| 4| 5| 4| 7| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 4| 3| 6| 8| 5| 2| 3| 7| 8| 7| 8| 3| 3| 3| 3| 5| 4| 5| 3| 3| 8| 3| 3| 3| 3|
| 8| 2| 1| 8| 9| 3| 2| 2| 0| 5| 5| 0| 7| 8| 1| 9| 1| 9| 1| 2| 1| 8| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5MG/M3 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | I I + + + + + + + I + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 1 3 1 1 2 3 2 2 3 1 1 1 4 1 3 1 1 4 2|
Clear Cell Focus | |
Congestion | 2 |
Degeneration, Cystic | 1 1 |
Degeneration, Fatty | 1 1 4 1 |
Eosinophilic Focus | 1 1 |
Hepatodiaphragmatic Nodule | X X X|
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 2 1 3 2 3 2 |
Centrilobular, Atrophy | 2 |
Hepatocyte, Necrosis | 1 2 1 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + M + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 1 2 2 2 2|
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | 1 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 4| 6| 6| 4| 3| 7| 2| 4| 4| 6| 7| 6| 5| 7| 4| 5| 4| 7| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 4| 3| 6| 8| 5| 2| 3| 7| 8| 7| 8| 3| 3| 3| 3| 5| 4| 5| 3| 3| 8| 3| 3| 3| 3|
| 8| 2| 1| 8| 9| 3| 2| 2| 0| 5| 5| 0| 7| 8| 1| 9| 1| 9| 1| 2| 1| 8| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5MG/M3 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 3 2 4 3 |
Necrosis | |
Vacuolization Cytoplasmic | 3 4 2 3 3 1 1 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + + + M M + + + + + M + + + + M + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Autolysis | 3 |
Cyst | |
Hemorrhage | |
Pars Distalis, Hyperplasia, Diffuse | |
Pars Distalis, Hyperplasia, Focal | 3 2 3 2 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
C-Cell, Hyperplasia | 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + + |
Hemorrhage | 4 |
Oral, Inflammation, Granulomatous | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hyperplasia | |
Hyperplasia, Squamous | 2 |
Inflammation | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Congestion | |
Cyst | |
Bilateral, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Inflammation | 3 |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 4| 6| 6| 4| 3| 7| 2| 4| 4| 6| 7| 6| 5| 7| 4| 5| 4| 7| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 4| 3| 6| 8| 5| 2| 3| 7| 8| 7| 8| 3| 3| 3| 3| 5| 4| 5| 3| 3| 8| 3| 3| 3| 3|
| 8| 2| 1| 8| 9| 3| 2| 2| 0| 5| 5| 0| 7| 8| 1| 9| 1| 9| 1| 2| 1| 8| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5MG/M3 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Necrosis | |
Myeloid Cell, Hyperplasia | 3 1 2 2 3 2 |
__________________________________________________________________________|
Lymph Node | + |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + I M + + + + + + + + + + + + + + + + M +|
Hyperplasia, Lymphoid | 1 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M M + + + + + + + + + I + + + I + + +|
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Macrophage | 3 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + + M + + + + + + + + + I + + + + + + +|
Congestion | 3 |
Hemorrhage | 4 |
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 2 2 |
Pigmentation | 3 1 1 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Autolysis | 3 |
Fibrosis | 2 3 |
Hematopoietic Cell Proliferation | 3 |
Inflammation, Focal | |
__________________________________________________________________________|
Thymus | + + + + + + + + + I + + + + + + + + + + + + + + +|
Atrophy | 1 3 2 2 1 2 3 |
Autolysis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Ectasia | 2 |
Duct, Hyperplasia | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 X |
__________________________________________________________________________|
Skeletal Muscle | + |
Hemorrhage | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 4 3 |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 4| 6| 6| 4| 3| 7| 2| 4| 4| 6| 7| 6| 5| 7| 4| 5| 4| 7| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 4| 3| 6| 8| 5| 2| 3| 7| 8| 7| 8| 3| 3| 3| 3| 5| 4| 5| 3| 3| 8| 3| 3| 3| 3|
| 8| 2| 1| 8| 9| 3| 2| 2| 0| 5| 5| 0| 7| 8| 1| 9| 1| 9| 1| 2| 1| 8| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5MG/M3 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Degeneration | 3 |
Hemorrhage | 3 |
Hydrocephalus | 1 |
Necrosis | |
__________________________________________________________________________|
Spinal Cord | + |
Meninges, Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + A + + + + + + + +|
Hyperplasia | |
Inflammation | 1 2 2 1 1 1 1|
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Squamous | X |
Fibrosis | 1 1 1 1 1 1 1 1 1 2 3 1 1 2 1 2 2 3 3 2 3 2 2|
Hyperplasia, Macrophage | 2 2 3 1 2 1 1 2 2 2 2 2 2 2 2 2 1 2 2 2 1 2|
Inflammation, Chronic Active | 2 1 2 3 1 1 2 1 1 2 3 2 1 3 2 1 1 2 3 3 2 3 2 3|
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 2 |
Alveolar Epithelium, Hyperplasia | 2 |
Alveolar Epithelium, Metaplasia, | |
Squamous | 3 2 |
Alveolus, Proteinosis | 2 2 3 4 2 2 4 2 1 2 4 2 1 4 1 2 1 3 2 2 2 4 2 4|
Interstitium, Infiltration Cellular | 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 2 |
Thrombosis | 1 |
Thrombosis, Multiple | |
Nasolacrimal Duct, Hyperplasia | 3 |
Nasolacrimal Duct, Inflammation | 3 1 3 1 2 2 1 |
Nasopharyngeal Duct, Hyperplasia | 1 |
Nasopharyngeal Duct, Inflammation | 2 |
Olfactory Epithelium, Atrophy | 2 1 1 1 |
Olfactory Epithelium, Degeneration | 1 1 1 1 1|
Respiratory Epithelium, Degeneration | 1 |
Respiratory Epithelium, Hyperplasia | 2 2 2 3 1 1 2 |
Respiratory Epithelium, Inflammation | 2 4 2 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + + |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 4| 6| 6| 4| 3| 7| 2| 4| 4| 6| 7| 6| 5| 7| 4| 5| 4| 7| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 4| 3| 6| 8| 5| 2| 3| 7| 8| 7| 8| 3| 3| 3| 3| 5| 4| 5| 3| 3| 8| 3| 3| 3| 3|
| 8| 2| 1| 8| 9| 3| 2| 2| 0| 5| 5| 0| 7| 8| 1| 9| 1| 9| 1| 2| 1| 8| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5MG/M3 | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cataract | |
Hemorrhage | 4 |
Phthisis Bulbi | X X |
Synechia | |
Anterior Chamber, Inflammation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Nephropathy | 1 1 2 1 3 2 2 1 2 1 1 2 1 1 2 3 1 2 2|
Pigmentation | |
Renal Tubule, Degeneration | |
Renal Tubule, Necrosis, Acute | 2 |
Renal Tubule, Pigmentation | 4 4 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 5| 4| 7| 7| 7| 7| 1| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 6| 1| 7| 6| 0| 6|
DAY ON TEST | 2| 3| 5| 3| 3| 0| 3| 1| 3| 2| 3| 5| 3| 3| 2| 3| 3| 3| 3| 9| 9| 2| 6| 2| 5|
| 9| 8| 9| 2| 0| 2| 0| 9| 0| 9| 0| 9| 1| 0| 7| 2| 1| 0| 2| 7| 0| 9| 2| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5MG/M3 | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + I + I + + + + + I + + + I I + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 3 2 2 4 2 1 3 1 1 3 1 2 1 2 2 2 3 1 2 |
Clear Cell Focus | 1 1 2 |
Congestion | |
Degeneration, Cystic | 1 2 |
Degeneration, Fatty | 4 2|
Eosinophilic Focus | 1 |
Hepatodiaphragmatic Nodule | X X X X |
Mixed Cell Focus | 2 |
Bile Duct, Hyperplasia | 2 3 2 4|
Centrilobular, Atrophy | 2 |
Hepatocyte, Necrosis | 2 1 3 2 |
__________________________________________________________________________|
Mesentery | +|
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Ulcer | 3|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 5| 4| 7| 7| 7| 7| 1| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 6| 1| 7| 6| 0| 6|
DAY ON TEST | 2| 3| 5| 3| 3| 0| 3| 1| 3| 2| 3| 5| 3| 3| 2| 3| 3| 3| 3| 9| 9| 2| 6| 2| 5|
| 9| 8| 9| 2| 0| 2| 0| 9| 0| 9| 0| 9| 1| 0| 7| 2| 1| 0| 2| 7| 0| 9| 2| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5MG/M3 | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hyperplasia | 1 2 1 |
Necrosis | |
Vacuolization Cytoplasmic | 4 1 3 3 3 2|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 3 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + M + + + + M +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Autolysis | |
Cyst | X X X |
Hemorrhage | 2 |
Pars Distalis, Hyperplasia, Diffuse | 1 |
Pars Distalis, Hyperplasia, Focal | 4 4 1 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + M + + + + + + + + + + + + + + M +|
Autolysis | |
C-Cell, Hyperplasia | 1 4 2 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Hemorrhage | |
Oral, Inflammation, Granulomatous | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 3 |
Hyperplasia | 4 3 |
Hyperplasia, Squamous | |
Inflammation | 4 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Congestion | 1 |
Cyst | X X X X X |
Bilateral, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation | |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 57
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 5| 4| 7| 7| 7| 7| 1| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 6| 1| 7| 6| 0| 6|
DAY ON TEST | 2| 3| 5| 3| 3| 0| 3| 1| 3| 2| 3| 5| 3| 3| 2| 3| 3| 3| 3| 9| 9| 2| 6| 2| 5|
| 9| 8| 9| 2| 0| 2| 0| 9| 0| 9| 0| 9| 1| 0| 7| 2| 1| 0| 2| 7| 0| 9| 2| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5MG/M3 | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Necrosis | |
Myeloid Cell, Hyperplasia | 2 |
__________________________________________________________________________|
Lymph Node | +|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + I + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 1 2 2 2 2 1 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + I + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Macrophage | |
Pigmentation, Hemosiderin | 2 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + + + + + + M + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | 1 2 2 2 1 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Autolysis | |
Fibrosis | 3|
Hematopoietic Cell Proliferation | |
Inflammation, Focal | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 3 4 |
Autolysis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Ectasia | |
Duct, Hyperplasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + M + + + + + + + + + + +|
Inflammation | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 |
__________________________________________________________________________|
Skeletal Muscle | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 3 |
_____________________________________________________________________________________________________________________|
Page 58
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 5| 4| 7| 7| 7| 7| 1| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 6| 1| 7| 6| 0| 6|
DAY ON TEST | 2| 3| 5| 3| 3| 0| 3| 1| 3| 2| 3| 5| 3| 3| 2| 3| 3| 3| 3| 9| 9| 2| 6| 2| 5|
| 9| 8| 9| 2| 0| 2| 0| 9| 0| 9| 0| 9| 1| 0| 7| 2| 1| 0| 2| 7| 0| 9| 2| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5MG/M3 | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 7|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Degeneration | |
Hemorrhage | |
Hydrocephalus | |
Necrosis | |
__________________________________________________________________________|
Spinal Cord | |
Meninges, Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | 1 2 1 1 2 2|
Metaplasia, Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst, Squamous | |
Fibrosis | 2 1 2 1 2 2 2 2 1 3 3 2 2 1 1 3 2 1 2 3|
Hyperplasia, Macrophage | 1 2 2 1 1 2 2 2 2 2 2 2 2 2 1 1 2 1 2 2 |
Inflammation, Chronic Active | 3 2 1 2 3 2 2 2 2 3 3 1 3 3 2 2 2 2 3 2 2 2 3|
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 2 2 2 1 2 |
Alveolar Epithelium, Hyperplasia | |
Alveolar Epithelium, Metaplasia, | |
Squamous | |
Alveolus, Proteinosis | 3 1 2 3 4 3 4 3 4 2 1 3 4 1 3 3 2 3 2 3 2 1|
Interstitium, Infiltration Cellular | 1 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Thrombosis | 1 |
Thrombosis, Multiple | X |
Nasolacrimal Duct, Hyperplasia | |
Nasolacrimal Duct, Inflammation | 1 |
Nasopharyngeal Duct, Hyperplasia | |
Nasopharyngeal Duct, Inflammation | |
Olfactory Epithelium, Atrophy | 1 2 2 |
Olfactory Epithelium, Degeneration | 1 1 1 1 |
Respiratory Epithelium, Degeneration | 1 1 |
Respiratory Epithelium, Hyperplasia | 1 2 2 3 2 |
Respiratory Epithelium, Inflammation | 1 2 1 1 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + + + + |
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 5| 4| 7| 7| 7| 7| 1| 7| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 6| 1| 7| 6| 0| 6|
DAY ON TEST | 2| 3| 5| 3| 3| 0| 3| 1| 3| 2| 3| 5| 3| 3| 2| 3| 3| 3| 3| 9| 9| 2| 6| 2| 5|
| 9| 8| 9| 2| 0| 2| 0| 9| 0| 9| 0| 9| 1| 0| 7| 2| 1| 0| 2| 7| 0| 9| 2| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5MG/M3 | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 7|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Cataract | 3 |
Hemorrhage | |
Phthisis Bulbi | X |
Synechia | 4 2 |
Anterior Chamber, Inflammation | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Nephropathy | 1 1 2 2 3 3 2 1 1 3 2 2 4 2 1 3 2 |
Pigmentation | 3 |
Renal Tubule, Degeneration | |
Renal Tubule, Necrosis, Acute | |
Renal Tubule, Pigmentation | 3 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 3| 5| 7| 7| 7| | |
DAY ON TEST | 3| 9| 2| 2| 3| 7| 6| 2| 2| 3| | |
| 1| 7| 9| 9| 2| 0| 8| 9| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.5MG/M3 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| | L |
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + I + + + + + | 50 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
Peyer's Patch, Hyperplasia | 3 | 3 3.3|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Basophilic Focus | 3 4 3 1 1 1 | 45 2.0|
Clear Cell Focus | 2 | 4 1.5|
Congestion | | 1 2.0|
Degeneration, Cystic | | 4 1.3|
Degeneration, Fatty | 4 | 7 2.4|
Eosinophilic Focus | | 3 1.0|
Hepatodiaphragmatic Nodule | X | 8 |
Mixed Cell Focus | | 1 2.0|
Bile Duct, Hyperplasia | 2 2 | 12 2.3|
Centrilobular, Atrophy | | 2 2.0|
Hepatocyte, Necrosis | 1 | 8 1.6|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Necrosis | | 1 3.0|
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Inflammation | 4 | 1 4.0|
Ulcer | 4 | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Cardiomyopathy | 2 | 13 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 3| 5| 7| 7| 7| | |
DAY ON TEST | 3| 9| 2| 2| 3| 7| 6| 2| 2| 3| | |
| 1| 7| 9| 9| 2| 0| 8| 9| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.5MG/M3 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| | L |
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Cytoplasmic Alteration | | 1 1.0|
Hyperplasia | 1 | 8 2.1|
Necrosis | 2 | 1 2.0|
Vacuolization Cytoplasmic | 3 2 | 16 2.4|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
Hyperplasia | 4 | 8 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 52 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Angiectasis | 1 | 2 2.5|
Autolysis | | 1 3.0|
Cyst | X | 4 |
Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia, Diffuse | | 1 1.0|
Pars Distalis, Hyperplasia, Focal | 3 2 2 4 | 13 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 57 |
Autolysis | | 1 4.0|
C-Cell, Hyperplasia | 1 2 3 | 8 1.9|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 5 |
Hemorrhage | | 1 4.0|
Oral, Inflammation, Granulomatous | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
Ectasia | | 3 3.0|
Hyperplasia | 2 | 3 3.0|
Hyperplasia, Squamous | | 1 2.0|
Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Atrophy | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 3| 5| 7| 7| 7| | |
DAY ON TEST | 3| 9| 2| 2| 3| 7| 6| 2| 2| 3| | |
| 1| 7| 9| 9| 2| 0| 8| 9| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.5MG/M3 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| | L |
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Congestion | | 1 1.0|
Cyst | | 5 |
Bilateral, Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Fibrosis | | 1 2.0|
Inflammation | | 1 3.0|
Endometrium, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Necrosis | 3 | 1 3.0|
Myeloid Cell, Hyperplasia | 2 2 | 9 2.1|
__________________________________________________________________________|____________|
Lymph Node | + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + + + + | 54 |
Hyperplasia, Lymphoid | 2 2 | 12 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 54 |
Hyperplasia, Lymphoid | | 3 2.0|
Hyperplasia, Plasma Cell | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
Hyperplasia, Macrophage | | 1 3.0|
Pigmentation, Hemosiderin | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M + + + M | 52 |
Congestion | | 1 3.0|
Hemorrhage | | 1 4.0|
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Lymphoid | | 7 1.7|
Pigmentation | | 4 1.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Atrophy | | 1 2.0|
Autolysis | | 1 3.0|
Fibrosis | | 3 2.7|
Hematopoietic Cell Proliferation | 3 1 | 3 2.3|
Inflammation, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + I + + + + | 57 |
Atrophy | 3 | 13 2.4|
Autolysis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 3| 5| 7| 7| 7| | |
DAY ON TEST | 3| 9| 2| 2| 3| 7| 6| 2| 2| 3| | |
| 1| 7| 9| 9| 2| 0| 8| 9| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.5MG/M3 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| | L |
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Duct, Ectasia | | 1 2.0|
Duct, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 58 |
Inflammation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
Hyperostosis | | 3 3.5|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Compression | | 5 3.6|
Degeneration | | 1 3.0|
Hemorrhage | | 1 3.0|
Hydrocephalus | | 1 1.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Meninges, Hemorrhage | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 58 |
Hyperplasia | 2 1 | 2 1.5|
Inflammation | 2 1 | 15 1.4|
Metaplasia, Squamous | | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Cyst, Squamous | X | 2 |
Fibrosis | 2 3 3 3 2 1 1 2 2 | 52 1.8|
Hyperplasia, Macrophage | 2 2 2 3 2 2 2 2 | 50 1.8|
Inflammation, Chronic Active | 3 3 3 3 3 2 1 2 3 2 | 57 2.2|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 2 | 10 1.7|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolar Epithelium, Metaplasia, | | |
Squamous | 1 1 | 4 1.8|
Alveolus, Proteinosis | 3 1 2 3 1 2 2 3 | 54 2.4|
Interstitium, Infiltration Cellular | 1 | 11 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 7| 4| 7| 7| 7| 3| 5| 7| 7| 7| | |
DAY ON TEST | 3| 9| 2| 2| 3| 7| 6| 2| 2| 3| | |
| 1| 7| 9| 9| 2| 0| 8| 9| 9| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.5MG/M3 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| | L |
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Congestion | | 1 3.0|
Hemorrhage | | 1 2.0|
Thrombosis | 1 | 3 1.0|
Thrombosis, Multiple | | 1 |
Nasolacrimal Duct, Hyperplasia | | 1 3.0|
Nasolacrimal Duct, Inflammation | | 8 1.8|
Nasopharyngeal Duct, Hyperplasia | | 1 1.0|
Nasopharyngeal Duct, Inflammation | | 1 2.0|
Olfactory Epithelium, Atrophy | 2 | 8 1.5|
Olfactory Epithelium, Degeneration | 1 1 1 | 12 1.0|
Respiratory Epithelium, Degeneration | 1 | 4 1.0|
Respiratory Epithelium, Hyperplasia | 1 1 1 1 2 | 17 1.7|
Respiratory Epithelium, Inflammation | 1 2 | 13 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
Autolysis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 7 |
Cataract | | 1 3.0|
Hemorrhage | | 1 4.0|
Phthisis Bulbi | | 3 |
Synechia | | 2 3.0|
Anterior Chamber, Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Autolysis | | 2 3.0|
Nephropathy | 2 1 3 1 2 1 1 2 | 44 1.8|
Pigmentation | | 1 3.0|
Renal Tubule, Degeneration | 2 | 1 2.0|
Renal Tubule, Necrosis, Acute | | 1 2.0|
Renal Tubule, Pigmentation | 3 | 6 2.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.5MG/M3 | 9| 0| 1| 2| 3| 4| 4| 5| 5| 6| | L |
LUNG TOX | 3| 1| 3| 1| 7| 5| 6| 7| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + | 5 |
Hyperplasia, Lymphoid | 1 1 1 2 | 4 1.3|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 5 |
Hyperplasia, Lymphoid | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Hyperplasia, Macrophage | 2 2 2 2 2 | 5 2.0|
Inflammation, Chronic Active | 2 2 2 2 2 | 5 2.0|
Alveolus, Proteinosis | 1 1 | 2 1.0|
Interstitium, Infiltration Cellular | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
Olfactory Epithelium, Atrophy | 1 | 1 1.0|
Respiratory Epithelium, Inflammation | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
0.5MG/M3 | 9| 0| 1| 2| 3| 4| 4| 5| 5| 6| | L |
LUNG TOX | 3| 1| 3| 1| 7| 5| 6| 7| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
Cataract | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 6| 5| 7| 4| 5| 6| 7| 7| 6| 4| 7| 4| 7| 5| 6| 6| 7| 7| 5| 7|
DAY ON TEST | 3| 6| 6| 2| 3| 1| 3| 3| 5| 1| 7| 2| 3| 1| 8| 3| 5| 3| 7| 2| 5| 3| 3| 6| 2|
| 6| 2| 5| 6| 7| 4| 6| 6| 8| 8| 9| 0| 6| 8| 2| 7| 8| 1| 7| 2| 7| 6| 3| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 3 2 2 |
Basophilic Focus | 2 1 1 1 1 1 2 1 3 1 1 3 2 2|
Clear Cell Focus | 1 |
Congestion | |
Cyst | |
Degeneration, Cystic | 1 1 2 2 1 2 2|
Degeneration, Fatty | |
Eosinophilic Focus | 1 2 |
Hepatodiaphragmatic Nodule | X X |
Infarct | |
Mixed Cell Focus | 1 |
Thrombosis | X X |
Bile Duct, Hyperplasia | 3 1 4 1 1 1 2 1 2 4 2 4 1 4 3 3 2 |
Centrilobular, Atrophy | 3 2 1 |
Hepatocyte, Hyperplasia | 1 |
Hepatocyte, Necrosis | 1 1 1 2 3 1 2 2 |
__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
__________________________________________________________________________|
Oral Mucosa | + + + |
Hyperplasia, Squamous | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
Infarct | |
Acinus, Atrophy | 2 4 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Inflammation | |
Perforation | |
Ulcer | 4 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 6| 5| 7| 4| 5| 6| 7| 7| 6| 4| 7| 4| 7| 5| 6| 6| 7| 7| 5| 7|
DAY ON TEST | 3| 6| 6| 2| 3| 1| 3| 3| 5| 1| 7| 2| 3| 1| 8| 3| 5| 3| 7| 2| 5| 3| 3| 6| 2|
| 6| 2| 5| 6| 7| 4| 6| 6| 8| 8| 9| 0| 6| 8| 2| 7| 8| 1| 7| 2| 7| 6| 3| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Necrosis | |
__________________________________________________________________________|
Tooth | + + + + |
Peridontal Tissue, Inflammation | 2 2 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 2 3 2 4 3 1 2 2 2 2|
Thrombosis | X X |
Epicardium, Inflammation | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 1 |
Hypertrophy | 3 |
Vacuolization Cytoplasmic | 2 3 2 2 1 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 4 4 2 3 4 1 4 4 2 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + I + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + I + + + + + + + + +|
Hyperplasia | 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hemorrhage | 4 |
Pars Distalis, Hyperplasia, Focal | 2 4 2 1 4 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 3 |
Follicular Cell, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Mediastinum, Polyarteritis | |
Oral, Inflammation | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Inflammation | 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
Inflammation | 1 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 6| 5| 7| 4| 5| 6| 7| 7| 6| 4| 7| 4| 7| 5| 6| 6| 7| 7| 5| 7|
DAY ON TEST | 3| 6| 6| 2| 3| 1| 3| 3| 5| 1| 7| 2| 3| 1| 8| 3| 5| 3| 7| 2| 5| 3| 3| 6| 2|
| 6| 2| 5| 6| 7| 4| 6| 6| 8| 8| 9| 0| 6| 8| 2| 7| 8| 1| 7| 2| 7| 6| 3| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Ectasia | |
Hyperplasia | 4 2 |
Infiltration Cellular | |
Inflammation | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3|
Cyst | X |
Interstitial Cell, Hyperplasia, Focal| 1 1 1 1 1 2 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Atrophy | 2 |
Erythroid Cell, Hyperplasia | 2 |
Myeloid Cell, Hyperplasia | 3 2 3 2 2 4 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Renal, Inflammation | |
Renal, Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M + + + + + + M + + + + + + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + M + + + + + I + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + M + + + + + + + + + + + + + + + M +|
Autolysis | 2 |
Hyperplasia, Lymphoid | |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Autolysis | 2 |
Congestion | |
Fibrosis | 2 2 2 3 2 3|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + I + + + + + + + + + + I +|
Atrophy | 3 2 3 2 2 4 2|
Congestion | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 6| 5| 7| 4| 5| 6| 7| 7| 6| 4| 7| 4| 7| 5| 6| 6| 7| 7| 5| 7|
DAY ON TEST | 3| 6| 6| 2| 3| 1| 3| 3| 5| 1| 7| 2| 3| 1| 8| 3| 5| 3| 7| 2| 5| 3| 3| 6| 2|
| 6| 2| 5| 6| 7| 4| 6| 6| 8| 8| 9| 0| 6| 8| 2| 7| 8| 1| 7| 2| 7| 6| 3| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + M + + + + + + M + + + M + + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Inflammation | 4 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | X |
Hyperostosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 |
Hemorrhage | 2 2 4 |
Ventricle, Hydrocephalus | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | |
Hemorrhage | 1 |
Hyperplasia, Macrophage | 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 1|
Metaplasia, Osseous | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Interstitium, Infiltration Cellular | 1 1 1 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis, Multiple | X X X |
Nasolacrimal Duct, Inflammation | 1 1 |
Nasopharyngeal Duct, Inflammation | 1 |
Olfactory Epithelium, Degeneration | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Respiratory Epithelium, Degeneration | 1 |
Respiratory Epithelium, Hyperplasia | 2 1 1 1 3 1 1 1 |
Respiratory Epithelium, Inflammation | 1 2 1 1 1 2 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 1 |
Vomeronasal Organ, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 6| 5| 6| 7| 6| 5| 7| 4| 5| 6| 7| 7| 6| 4| 7| 4| 7| 5| 6| 6| 7| 7| 5| 7|
DAY ON TEST | 3| 6| 6| 2| 3| 1| 3| 3| 5| 1| 7| 2| 3| 1| 8| 3| 5| 3| 7| 2| 5| 3| 3| 6| 2|
| 6| 2| 5| 6| 7| 4| 6| 6| 8| 8| 9| 0| 6| 8| 2| 7| 8| 1| 7| 2| 7| 6| 3| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Cataract | |
Retinal Detachment | |
Synechia | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Infarct | |
Nephropathy | 4 2 1 4 3 2 1 3 1 1 3 4 4 3 4 2 3 1 1 2 4 4 2 4|
Renal Tubule, Pigmentation | 1 2 3 2 |
__________________________________________________________________________|
Urethra | |
Calculus Micro Observation Only | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X X |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 5| 7| 1| 4| 7| 7| 2| 7| 6| 6| 6| 5| 6| 5| 4| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 5| 5| 3| 2| 3| 3| 1| 9| 3| 0| 6| 3| 5| 5| 3| 9| 8| 5| 5| 3| 3| 3| 0| 3| 3|
| 8| 5| 6| 6| 9| 7| 7| 6| 3| 8| 2| 7| 7| 8| 7| 7| 6| 0| 8| 7| 3| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
| 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | 3 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 3 |
Basophilic Focus | 1 1 1 1 2 3 1 1 1 1 1 1 2 1 2 1|
Clear Cell Focus | 1 |
Congestion | 1 2 |
Cyst | |
Degeneration, Cystic | 1 1 1 |
Degeneration, Fatty | 1 2 1 1 1 |
Eosinophilic Focus | 1 1 |
Hepatodiaphragmatic Nodule | X X |
Infarct | 3 |
Mixed Cell Focus | 1 |
Thrombosis | X |
Bile Duct, Hyperplasia | 1 3 3 3 3 2 2 2 2 1 2 1 3 |
Centrilobular, Atrophy | 2 |
Hepatocyte, Hyperplasia | |
Hepatocyte, Necrosis | 1 1 1 3 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis | 4 |
__________________________________________________________________________|
Oral Mucosa | |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Pancreas | + + + + + + M + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration | |
Infarct | 2 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Inflammation | |
Perforation | |
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 5| 7| 1| 4| 7| 7| 2| 7| 6| 6| 6| 5| 6| 5| 4| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 5| 5| 3| 2| 3| 3| 1| 9| 3| 0| 6| 3| 5| 5| 3| 9| 8| 5| 5| 3| 3| 3| 0| 3| 3|
| 8| 5| 6| 6| 9| 7| 7| 6| 3| 8| 2| 7| 7| 8| 7| 7| 6| 0| 8| 7| 3| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
| 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Necrosis | 1 |
__________________________________________________________________________|
Tooth | + + + +|
Peridontal Tissue, Inflammation | 3 2 3 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 1 2 2 2 3 2 3 2 3|
Thrombosis | X X X X X |
Epicardium, Inflammation | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia | 2 1 |
Hypertrophy | |
Vacuolization Cytoplasmic | 3 2 4 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | 2 1 4 4 2 1 2 4 1 1 2 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + M + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + M + + M + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 3 1 2 3 4 3 2 3 2 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 4 |
Follicular Cell, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Mediastinum, Polyarteritis | X |
Oral, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
Inflammation | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | |
Inflammation | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
Page 74
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 5| 7| 1| 4| 7| 7| 2| 7| 6| 6| 6| 5| 6| 5| 4| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 5| 5| 3| 2| 3| 3| 1| 9| 3| 0| 6| 3| 5| 5| 3| 9| 8| 5| 5| 3| 3| 3| 0| 3| 3|
| 8| 5| 6| 6| 9| 7| 7| 6| 3| 8| 2| 7| 7| 8| 7| 7| 6| 0| 8| 7| 3| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
| 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Ectasia | 1 4 |
Hyperplasia | 3 |
Infiltration Cellular | 2 |
Inflammation | 2|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 |
Ectasia | 3|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 4 |
Cyst | |
Interstitial Cell, Hyperplasia, Focal| 1 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 1 |
Atrophy | |
Erythroid Cell, Hyperplasia | 3 |
Myeloid Cell, Hyperplasia | 4 1 2 2 |
__________________________________________________________________________|
Lymph Node | + + |
Renal, Inflammation | |
Renal, Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + I + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 4 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 1 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + I + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Macrophage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Autolysis | |
Congestion | 2 2 3 2 2 |
Fibrosis | 3 3 2 2 2 3 |
__________________________________________________________________________|
Thymus | + M + + + + + + + M + + + + + + + + + + + M + + +|
Atrophy | 1 2 4 3 3 3 2 |
Congestion | 2 |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 5| 7| 1| 4| 7| 7| 2| 7| 6| 6| 6| 5| 6| 5| 4| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 5| 5| 3| 2| 3| 3| 1| 9| 3| 0| 6| 3| 5| 5| 3| 9| 8| 5| 5| 3| 3| 3| 0| 3| 3|
| 8| 5| 6| 6| 9| 7| 7| 6| 3| 8| 2| 7| 7| 8| 7| 7| 6| 0| 8| 7| 3| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
| 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + M M + + + + + + + + M + M M + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 4|
Hemorrhage | |
Ventricle, Hydrocephalus | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fibrosis | 1 1 1 |
Hemorrhage | |
Hyperplasia, Macrophage | 1 3 |
Inflammation, Chronic Active | 1 2 1 1 1 1 |
Metaplasia, Osseous | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
Interstitium, Infiltration Cellular | 1 1 1 1 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis, Multiple | X X X X |
Nasolacrimal Duct, Inflammation | 2 1 |
Nasopharyngeal Duct, Inflammation | 3 |
Olfactory Epithelium, Degeneration | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Respiratory Epithelium, Degeneration | 1 |
Respiratory Epithelium, Hyperplasia | 1 2 1 1 1 1 2 1 |
Respiratory Epithelium, Inflammation | 1 2 1 1 2 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | |
Vomeronasal Organ, Inflammation | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 4| 6| 7| 7| 5| 7| 1| 4| 7| 7| 2| 7| 6| 6| 6| 5| 6| 5| 4| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 5| 5| 3| 2| 3| 3| 1| 9| 3| 0| 6| 3| 5| 5| 3| 9| 8| 5| 5| 3| 3| 3| 0| 3| 3|
| 8| 5| 6| 6| 9| 7| 7| 6| 3| 8| 2| 7| 7| 8| 7| 7| 6| 0| 8| 7| 3| 3| 3| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
| 0| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retinal Detachment | 4 |
Synechia | 4 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | 2 |
Nephropathy | 1 1 4 4 1 3 1 4 3 4 1 1 4 2 3 2 1 4 3 3 3 2 4|
Renal Tubule, Pigmentation | 2 1 2 |
__________________________________________________________________________|
Urethra | + |
Calculus Micro Observation Only | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 4| 7| 6| 5| | |
DAY ON TEST | 2| 9| 0| 0| 7| 5| 3| 1| 3| | |
| 2| 3| 3| 5| 9| 8| 6| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 5| 6| 6| 6| 6| 6| 6| 6| 6| | L |
| 9| 0| 1| 3| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 59 |
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + | 59 |
Parasite Metazoan | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 59 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 59 |
Peyer's Patch, Hyperplasia | | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 59 |
Angiectasis | | 6 2.0|
Basophilic Focus | 1 3 3 3 | 34 1.6|
Clear Cell Focus | | 2 1.0|
Congestion | | 2 1.5|
Cyst | X | 1 |
Degeneration, Cystic | 1 | 11 1.4|
Degeneration, Fatty | 2 | 6 1.3|
Eosinophilic Focus | X | 5 1.3|
Hepatodiaphragmatic Nodule | X | 5 |
Infarct | | 1 3.0|
Mixed Cell Focus | | 2 1.0|
Thrombosis | X | 4 |
Bile Duct, Hyperplasia | 4 4 1 2 1 3 | 36 2.3|
Centrilobular, Atrophy | 2 2 | 6 2.0|
Hepatocyte, Hyperplasia | | 1 1.0|
Hepatocyte, Necrosis | 1 2 | 16 1.5|
__________________________________________________________________________|____________|
Mesentery | | 2 |
Fat, Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Oral Mucosa | | 3 |
Hyperplasia, Squamous | | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 58 |
Cytoplasmic Alteration | 2 | 1 2.0|
Infarct | | 1 2.0|
Acinus, Atrophy | 2 3 3 | 6 2.7|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 59 |
Hyperplasia, Squamous | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 4| 7| 6| 5| | |
DAY ON TEST | 2| 9| 0| 0| 7| 5| 3| 1| 3| | |
| 2| 3| 3| 5| 9| 8| 6| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 5| 6| 6| 6| 6| 6| 6| 6| 6| | L |
| 9| 0| 1| 3| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Inflammation | 4 | 1 4.0|
Perforation | X | 1 |
Ulcer | | 4 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 59 |
Erosion | | 1 2.0|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + | 9 |
Peridontal Tissue, Inflammation | 1 | 9 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 59 |
Cardiomyopathy | 3 3 2 3 3 | 31 2.2|
Thrombosis | X | 8 |
Epicardium, Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + | 59 |
Atrophy | 3 | 1 3.0|
Hyperplasia | | 3 1.3|
Hypertrophy | | 1 3.0|
Vacuolization Cytoplasmic | 2 | 11 2.2|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + | 59 |
Cyst | X | 1 |
Hyperplasia | 2 1 2 2 | 28 2.4|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 57 |
Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + | 54 |
Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 59 |
Angiectasis | | 3 2.0|
Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia, Focal | | 16 2.4|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 58 |
C-Cell, Hyperplasia | | 5 2.6|
Follicular Cell, Hyperplasia, Cystic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 4 |
Mediastinum, Polyarteritis | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 4| 7| 6| 5| | |
DAY ON TEST | 2| 9| 0| 0| 7| 5| 3| 1| 3| | |
| 2| 3| 3| 5| 9| 8| 6| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 5| 6| 6| 6| 6| 6| 6| 6| 6| | L |
| 9| 0| 1| 3| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
Oral, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + | 59 |
Atrophy | | 1 2.0|
Ectasia | | 2 2.5|
Hyperplasia | | 3 3.0|
Infiltration Cellular | | 1 2.0|
Inflammation | | 2 2.5|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + | 59 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + | 59 |
Atrophy | | 2 2.0|
Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 59 |
Atrophy | 4 | 7 3.1|
Cyst | | 1 |
Interstitial Cell, Hyperplasia, Focal| | 11 1.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 59 |
Atrophy, Focal | | 1 1.0|
Atrophy | | 1 2.0|
Erythroid Cell, Hyperplasia | | 2 2.5|
Myeloid Cell, Hyperplasia | 3 2 | 17 2.4|
__________________________________________________________________________|____________|
Lymph Node | + | 11 |
Renal, Inflammation | 2 | 1 2.0|
Renal, Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + M + + | 56 |
Inflammation | | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + | 55 |
Hyperplasia, Lymphoid | 2 4 | 5 3.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 4| 7| 6| 5| | |
DAY ON TEST | 2| 9| 0| 0| 7| 5| 3| 1| 3| | |
| 2| 3| 3| 5| 9| 8| 6| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 5| 6| 6| 6| 6| 6| 6| 6| 6| | L |
| 9| 0| 1| 3| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Congestion | | 1 2.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Pigmentation, Hemosiderin | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + | 56 |
Autolysis | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 3 2.0|
Hyperplasia, Macrophage | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 59 |
Atrophy | | 1 3.0|
Autolysis | | 1 2.0|
Congestion | | 5 2.2|
Fibrosis | 3 | 13 2.5|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + | 54 |
Atrophy | 3 4 | 16 2.7|
Congestion | | 1 2.0|
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Skin | + + + I + + + + + | 58 |
Angiectasis | 3 | 1 3.0|
Inflammation | | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 59 |
Fibrous Osteodystrophy | | 1 |
Hyperostosis | 4 | 2 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 59 |
Compression | 3 2 | 5 2.8|
Hemorrhage | | 3 2.7|
Ventricle, Hydrocephalus | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + | 59 |
Inflammation | 2 1 | 8 1.4|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 59 |
Congestion | 1 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 6| 6| 7| 5| 6| 4| 7| 6| 5| | |
DAY ON TEST | 2| 9| 0| 0| 7| 5| 3| 1| 3| | |
| 2| 3| 3| 5| 9| 8| 6| 0| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 5| 6| 6| 6| 6| 6| 6| 6| 6| | L |
| 9| 0| 1| 3| 5| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Fibrosis | | 3 1.0|
Hemorrhage | 2 | 2 1.5|
Hyperplasia, Macrophage | 1 1 | 7 1.3|
Inflammation, Chronic Active | 2 1 | 14 1.1|
Metaplasia, Osseous | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 3 2.0|
Interstitium, Infiltration Cellular | 1 | 12 1.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 59 |
Thrombosis, Multiple | X | 8 |
Nasolacrimal Duct, Inflammation | | 4 1.3|
Nasopharyngeal Duct, Inflammation | | 2 2.0|
Olfactory Epithelium, Degeneration | 1 1 1 1 1 1 1 | 39 1.0|
Respiratory Epithelium, Degeneration | | 2 1.0|
Respiratory Epithelium, Hyperplasia | 1 1 | 18 1.3|
Respiratory Epithelium, Inflammation | 1 1 | 14 1.3|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 2 1.0|
Vomeronasal Organ, Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 3.0|
Retinal Detachment | | 1 4.0|
Synechia | | 1 4.0|
__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 59 |
Cyst | | 2 |
Infarct | | 1 2.0|
Nephropathy | 3 4 3 1 3 2 1 4 | 55 2.6|
Renal Tubule, Pigmentation | | 7 1.9|
__________________________________________________________________________|____________|
Urethra | | 1 |
Calculus Micro Observation Only | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 59 |
Calculus Micro Observation Only | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 0| 2| 2| 2| 3| 3| 3| 4| 6| 6| 7| | L |
LUNG TOX | 5| 2| 6| 9| 1| 4| 8| 8| 2| 4| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M + + | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Interstitium, Infiltration Cellular | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 5| 3| 5| 7| 6| 7| 6| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 4| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 8| 6| 5| 3| 4| 3| 4| 0| 7| 7| 8| 0| 4| 3| 3| 3| 1| 4| 5| 0| 3| 5| 0| 3|
| 7| 0| 3| 1| 3| 6| 7| 0| 0| 9| 0| 5| 7| 7| 7| 7| 2| 5| 4| 8| 3| 7| 8| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.12 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
MG/M3 | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Peyer's Patch, Hyperplasia | 4 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + + + + + + + + + + + M + + + + +|
Autolysis | 4 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 4 2 3 |
Autolysis | 4 |
Basophilic Focus | 3 2 1 1 2 1 1 2 3 2 1 3 1 2 2 1|
Clear Cell Focus | 1 1 1 1 |
Degeneration, Cystic | 2 1 1 1 1 1 2 |
Degeneration, Fatty | 2 2 |
Eosinophilic Focus | 1 1 2 3 |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | 1 1 |
Thrombosis | X |
Bile Duct, Hyperplasia | 4 4 2 1 2 3 4 2 2 2 4 |
Centrilobular, Atrophy | 2 3 |
Hepatocyte, Hyperplasia | |
Hepatocyte, Necrosis | 2 2 2 1 1 2 |
__________________________________________________________________________|
Mesentery | + |
Cyst | |
__________________________________________________________________________|
Oral Mucosa | |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 5| 3| 5| 7| 6| 7| 6| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 4| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 8| 6| 5| 3| 4| 3| 4| 0| 7| 7| 8| 0| 4| 3| 3| 3| 1| 4| 5| 0| 3| 5| 0| 3|
| 7| 0| 3| 1| 3| 6| 7| 0| 0| 9| 0| 5| 7| 7| 7| 7| 2| 5| 4| 8| 3| 7| 8| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.12 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
MG/M3 | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Autolysis | 3 |
Inflammation | 1 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 1 2 1 3 1 1 3 3 2 2 1 3 2 3|
Inflammation | |
Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Cyst | |
Cytoplasmic Alteration | 2 |
Hyperplasia | |
Vacuolization Cytoplasmic | 2 2 2 2 2 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | 2 2 4 1 2 3 2|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + A + + + + + + +|
Angiectasis | 4 3 |
Pars Distalis, Hyperplasia, Diffuse | 1 |
Pars Distalis, Hyperplasia, Focal | 1 2 2 2 2 3 2 4 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
C-Cell, Hyperplasia | 1 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + |
Inflammation | 3 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | 2 1 |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 5| 3| 5| 7| 6| 7| 6| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 4| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 8| 6| 5| 3| 4| 3| 4| 0| 7| 7| 8| 0| 4| 3| 3| 3| 1| 4| 5| 0| 3| 5| 0| 3|
| 7| 0| 3| 1| 3| 6| 7| 0| 0| 9| 0| 5| 7| 7| 7| 7| 2| 5| 4| 8| 3| 7| 8| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.12 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
MG/M3 | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation | 3 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + M + +|
Inflammation | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 |
Hyperplasia, Cystic | 2 |
Hyperplasia | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 2 |
Cyst | X|
Interstitial Cell, Hyperplasia, Focal| 3 1 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + A + + + + + + +|
Atrophy | |
Erythroid Cell, Hyperplasia | |
Myeloid Cell, Hyperplasia | 3 2 4 3 3 2 |
__________________________________________________________________________|
Lymph Node | + |
Inguinal, Inflammation, Granulomatous| 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + I + + + + + + + + + + + + + + M + + + +|
Autolysis | 2 |
Congestion | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 4 |
Hyperplasia, Plasma Cell | 4 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Congestion | 2 4 |
Hyperplasia, Lymphoid | 1 1 2 |
Hyperplasia, Plasma Cell | 2 |
Pigmentation, Hemosiderin | 4 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 3 |
Autolysis | 4 |
Congestion | 2 2 |
Fibrosis | 2 3 3 2 1 2 3 3|
Hematopoietic Cell Proliferation | 3 |
Infarct | |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + A + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 5| 3| 5| 7| 6| 7| 6| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 4| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 8| 6| 5| 3| 4| 3| 4| 0| 7| 7| 8| 0| 4| 3| 3| 3| 1| 4| 5| 0| 3| 5| 0| 3|
| 7| 0| 3| 1| 3| 6| 7| 0| 0| 9| 0| 5| 7| 7| 7| 7| 2| 5| 4| 8| 3| 7| 8| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.12 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
MG/M3 | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | 3 3 3 3 3 3 4 2 |
Autolysis | 4 |
Congestion | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X X X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 1 4 4 |
Degeneration | 1 |
Hemorrhage | 2 |
Hydrocephalus | 1 |
Infarct | 4 |
Infiltration Cellular, Histiocyte | 3 |
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 2 2 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Congestion | 3 |
Emphysema | 1 |
Fibrosis | 1 |
Hemorrhage | 1 2 2 1 2 |
Hyperplasia, Macrophage | 1 1 1 |
Inflammation, Chronic Active | 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Interstitium, Infiltration Cellular | 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 1 1 1 |
Thrombosis, Multiple | |
Nasolacrimal Duct, Inflammation | 1 2 3|
Nasopharyngeal Duct, Hyperplasia, | |
Lymphoid | 3 |
Nasopharyngeal Duct, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 5| 3| 5| 7| 6| 7| 6| 6| 6| 5| 6| 6| 5| 7| 7| 6| 6| 6| 4| 7| 7| 4| 7| 7|
DAY ON TEST | 3| 8| 6| 5| 3| 4| 3| 4| 0| 7| 7| 8| 0| 4| 3| 3| 3| 1| 4| 5| 0| 3| 5| 0| 3|
| 7| 0| 3| 1| 3| 6| 7| 0| 0| 9| 0| 5| 7| 7| 7| 7| 2| 5| 4| 8| 3| 7| 8| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.12 | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6|
MG/M3 | 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 7| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Nasopharyngeal Duct, Inflammation | 2 1 1 |
Olfactory Epithelium, Degeneration | 1 1 1 1 1 |
Olfactory Epithelium, Necrosis | 1 |
Respiratory Epithelium, Degeneration | |
Respiratory Epithelium, Hyperplasia | 1 1 2 1 1 2|
Respiratory Epithelium, Inflammation | 2 1 1|
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +|
Cyst | X |
Infarct | 2 |
Inflammation | |
Nephropathy | 4 1 1 4 2 3 2 2 3 2 3 1 2 4 4 4 2 1 3 4 1 4 3|
Renal Tubule, Pigmentation | 2 4 3 2 3 |
__________________________________________________________________________|
Urethra | + |
Calculus Micro Observation Only | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 4 |
Calculus Micro Observation Only | X X |
_____________________________________________________________________________________________________________________|
Page 88
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7| 4| 6| 4| 7| 7| 7| 3| 7| 7| 7|
DAY ON TEST | 7| 4| 3| 0| 9| 9| 3| 2| 2| 3| 0| 4| 5| 8| 3| 5| 5| 5| 3| 3| 3| 5| 3| 2| 2|
| 5| 3| 9| 4| 2| 8| 6| 6| 0| 6| 8| 0| 0| 3| 6| 8| 8| 8| 7| 3| 2| 2| 6| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
0.12 | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + M + + + + + + + + + + + + + +|
Autolysis | |
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Autolysis | |
Basophilic Focus | 1 1 2 2 2 4 1 2 1 3 3 1 |
Clear Cell Focus | |
Degeneration, Cystic | 2 1 1 2 2 |
Degeneration, Fatty | 2 2 4 |
Eosinophilic Focus | 1 2 |
Hepatodiaphragmatic Nodule | X |
Mixed Cell Focus | |
Thrombosis | |
Bile Duct, Hyperplasia | 3 3 2 3 3 1 4 4 2 3 2 2 2 4 3 1|
Centrilobular, Atrophy | 2 |
Hepatocyte, Hyperplasia | 3 |
Hepatocyte, Necrosis | 2 2 2 2 2 1 1 3 |
__________________________________________________________________________|
Mesentery | + + |
Cyst | X |
__________________________________________________________________________|
Oral Mucosa | + |
Hyperplasia, Squamous | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + M + + +|
Acinus, Atrophy | 2 4 3 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 89
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7| 4| 6| 4| 7| 7| 7| 3| 7| 7| 7|
DAY ON TEST | 7| 4| 3| 0| 9| 9| 3| 2| 2| 3| 0| 4| 5| 8| 3| 5| 5| 5| 3| 3| 3| 5| 3| 2| 2|
| 5| 3| 9| 4| 2| 8| 6| 6| 0| 6| 8| 0| 0| 3| 6| 8| 8| 8| 7| 3| 2| 2| 6| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
0.12 | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Autolysis | |
Inflammation | 3 |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | + + |
Peridontal Tissue, Inflammation | 2 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 3 2 1 2 2 2 3 2 3 2 2 |
Inflammation | |
Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | X |
Cytoplasmic Alteration | |
Hyperplasia | 3 1 4 2 2 1 |
Vacuolization Cytoplasmic | 2 3 2 1|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Hyperplasia | 2 1 3 3 3 1 2 2 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + M + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + + M + + + + + + + I + M + + + + + + +|
Hyperplasia | 1 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 4 3 3 |
Pars Distalis, Hyperplasia, Diffuse | |
Pars Distalis, Hyperplasia, Focal | 4 2 4 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
C-Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | + + |
Inflammation | 3 2 |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 |
Ectasia | 2 2 |
_____________________________________________________________________________________________________________________|
Page 90
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7| 4| 6| 4| 7| 7| 7| 3| 7| 7| 7|
DAY ON TEST | 7| 4| 3| 0| 9| 9| 3| 2| 2| 3| 0| 4| 5| 8| 3| 5| 5| 5| 3| 3| 3| 5| 3| 2| 2|
| 5| 3| 9| 4| 2| 8| 6| 6| 0| 6| 8| 0| 0| 3| 6| 8| 8| 8| 7| 3| 2| 2| 6| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
0.12 | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 4 4 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hyperplasia, Cystic | |
Hyperplasia | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Cyst | |
Interstitial Cell, Hyperplasia, Focal| 1 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Erythroid Cell, Hyperplasia | |
Myeloid Cell, Hyperplasia | 3 3 1 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Inguinal, Inflammation, Granulomatous| |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + I + + + + + + + +|
Autolysis | |
Congestion | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M + M + + + + + + + + M + M I + + + M + +|
Autolysis | 2 |
Congestion | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Atrophy | 3 |
Autolysis | |
Congestion | |
Fibrosis | 2 2 2 3 1 1 3 |
Hematopoietic Cell Proliferation | |
Infarct | 2 |
Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + M + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
Page 91
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7| 4| 6| 4| 7| 7| 7| 3| 7| 7| 7|
DAY ON TEST | 7| 4| 3| 0| 9| 9| 3| 2| 2| 3| 0| 4| 5| 8| 3| 5| 5| 5| 3| 3| 3| 5| 3| 2| 2|
| 5| 3| 9| 4| 2| 8| 6| 6| 0| 6| 8| 0| 0| 3| 6| 8| 8| 8| 7| 3| 2| 2| 6| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
0.12 | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Atrophy | 2 2 2 2 |
Autolysis | |
Congestion | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + M + M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 |
Degeneration | 1 |
Hemorrhage | 4 |
Hydrocephalus | |
Infarct | |
Infiltration Cellular, Histiocyte | |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + A + + +|
Inflammation | 1 1 2 1 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Congestion | 3 2 |
Emphysema | |
Fibrosis | 1 2 1 1|
Hemorrhage | |
Hyperplasia, Macrophage | 1 1 2 1|
Inflammation, Chronic Active | 1 2 1 2 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Interstitium, Infiltration Cellular | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + A + + +|
Thrombosis | 1 1 |
Thrombosis, Multiple | |
Nasolacrimal Duct, Inflammation | 2 |
Nasopharyngeal Duct, Hyperplasia, | |
Lymphoid | |
Nasopharyngeal Duct, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 92
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 6| 6| 5| 7| 6| 5| 7| 7| 7| 7| 7| 6| 6| 6| 7| 4| 6| 4| 7| 7| 7| 3| 7| 7| 7|
DAY ON TEST | 7| 4| 3| 0| 9| 9| 3| 2| 2| 3| 0| 4| 5| 8| 3| 5| 5| 5| 3| 3| 3| 5| 3| 2| 2|
| 5| 3| 9| 4| 2| 8| 6| 6| 0| 6| 8| 0| 0| 3| 6| 8| 8| 8| 7| 3| 2| 2| 6| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
0.12 | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 1|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Nasopharyngeal Duct, Inflammation | 3 |
Olfactory Epithelium, Degeneration | 1 1 1 1 1 1 1 1 1 1 |
Olfactory Epithelium, Necrosis | |
Respiratory Epithelium, Degeneration | 1 |
Respiratory Epithelium, Hyperplasia | 2 3 2 1 1 1 3 |
Respiratory Epithelium, Inflammation | 1 2 2 1 1 2 3 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | |
Inflammation | |
Nephropathy | 3 2 3 2 4 2 4 3 3 1 2 1 2 2 2 1 2 4 4 2 3|
Renal Tubule, Pigmentation | 4 |
__________________________________________________________________________|
Urethra | + + |
Calculus Micro Observation Only | X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Calculus Micro Observation Only | X |
_____________________________________________________________________________________________________________________|
Page 93
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 5| 6| 5| | |
DAY ON TEST | 8| 5| 3| 3| 3| 6| 8| 6| | |
| 2| 8| 3| 6| 6| 6| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.12 | 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 2| 3| 4| 5| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 58 |
Autolysis | | 1 4.0|
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 58 |
Autolysis | | 1 4.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 58 |
Autolysis | | 1 4.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 58 |
Autolysis | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 57 |
Autolysis | | 1 4.0|
Peyer's Patch, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + I | 55 |
Autolysis | | 1 4.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 58 |
Angiectasis | 2 2 3 2 | 11 2.5|
Autolysis | | 1 4.0|
Basophilic Focus | 3 3 3 1 | 32 1.9|
Clear Cell Focus | 2 | 5 1.2|
Degeneration, Cystic | 1 | 13 1.4|
Degeneration, Fatty | | 5 2.4|
Eosinophilic Focus | 4 | 7 2.0|
Hepatodiaphragmatic Nodule | | 2 |
Mixed Cell Focus | 1 | 3 1.0|
Thrombosis | | 1 |
Bile Duct, Hyperplasia | 2 3 3 3 4 3 | 33 2.7|
Centrilobular, Atrophy | 2 | 4 2.3|
Hepatocyte, Hyperplasia | 4 | 2 3.5|
Hepatocyte, Necrosis | 2 1 3 1 | 18 1.8|
__________________________________________________________________________|____________|
Mesentery | + | 4 |
Cyst | | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | + | 2 |
Hyperplasia, Squamous | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 57 |
Acinus, Atrophy | 2 2 2 | 6 2.5|
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 5| 6| 5| | |
DAY ON TEST | 8| 5| 3| 3| 3| 6| 8| 6| | |
| 2| 8| 3| 6| 6| 6| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.12 | 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 2| 3| 4| 5| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 58 |
Diverticulum | 3 | 1 3.0|
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 58 |
Autolysis | | 1 3.0|
Inflammation | | 2 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 3 |
Peridontal Tissue, Inflammation | | 3 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 58 |
Cardiomyopathy | 3 2 | 31 2.1|
Inflammation | 2 | 1 2.0|
Thrombosis | X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 58 |
Atrophy | 1 3 | 3 2.0|
Cyst | | 1 |
Cytoplasmic Alteration | | 1 2.0|
Hyperplasia | 1 | 7 2.0|
Vacuolization Cytoplasmic | | 10 2.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 58 |
Hemorrhage | | 1 4.0|
Hyperplasia | 1 4 3 | 20 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 56 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 54 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 56 |
Angiectasis | 3 | 7 3.3|
Pars Distalis, Hyperplasia, Diffuse | 2 | 2 1.5|
Pars Distalis, Hyperplasia, Focal | 2 1 2 | 16 2.2|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 58 |
Autolysis | | 1 3.0|
C-Cell, Hyperplasia | 1 | 7 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 5| 6| 5| | |
DAY ON TEST | 8| 5| 3| 3| 3| 6| 8| 6| | |
| 2| 8| 3| 6| 6| 6| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.12 | 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 2| 3| 4| 5| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | | 3 |
Inflammation | | 3 2.7|
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 58 |
Atrophy | | 2 1.5|
Ectasia | 4 | 5 2.2|
Inflammation | | 5 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 57 |
Inflammation | | 4 3.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 58 |
Atrophy | | 3 2.3|
Hyperplasia, Cystic | | 1 2.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 58 |
Atrophy | 4 | 3 3.3|
Cyst | | 1 |
Interstitial Cell, Hyperplasia, Focal| 1 | 7 1.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 57 |
Atrophy | | 1 3.0|
Erythroid Cell, Hyperplasia | 2 | 1 2.0|
Myeloid Cell, Hyperplasia | 3 4 | 11 2.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + | 14 |
Inguinal, Inflammation, Granulomatous| | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + I + + + | 54 |
Autolysis | | 1 2.0|
Congestion | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + | 57 |
Hyperplasia, Lymphoid | 2 | 3 2.7|
Hyperplasia, Plasma Cell | | 2 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 58 |
Autolysis | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + | 52 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 5| 6| 5| | |
DAY ON TEST | 8| 5| 3| 3| 3| 6| 8| 6| | |
| 2| 8| 3| 6| 6| 6| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.12 | 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 2| 3| 4| 5| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Autolysis | 3 | 2 2.5|
Congestion | | 2 3.0|
Hyperplasia, Lymphoid | | 3 1.3|
Hyperplasia, Plasma Cell | | 1 2.0|
Pigmentation, Hemosiderin | | 1 4.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 58 |
Angiectasis | 4 | 2 4.0|
Atrophy | | 2 3.0|
Autolysis | | 1 4.0|
Congestion | | 2 2.0|
Fibrosis | 2 | 16 2.2|
Hematopoietic Cell Proliferation | | 1 3.0|
Infarct | | 1 2.0|
Pigmentation, Hemosiderin | | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + | 53 |
Atrophy | 2 | 13 2.6|
Autolysis | | 1 4.0|
Congestion | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M M | 53 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 58 |
Cyst Epithelial Inclusion | | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 58 |
Hyperostosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 58 |
Compression | | 5 2.8|
Degeneration | | 2 1.0|
Hemorrhage | | 2 3.0|
Hydrocephalus | | 1 1.0|
Infarct | | 1 4.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 5| 6| 5| | |
DAY ON TEST | 8| 5| 3| 3| 3| 6| 8| 6| | |
| 2| 8| 3| 6| 6| 6| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.12 | 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 2| 3| 4| 5| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + | 57 |
Inflammation | | 9 1.3|
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 58 |
Autolysis | | 1 3.0|
Congestion | | 3 2.7|
Emphysema | | 1 1.0|
Fibrosis | 1 | 6 1.2|
Hemorrhage | | 5 1.6|
Hyperplasia, Macrophage | 2 1 | 9 1.2|
Inflammation, Chronic Active | 1 | 12 1.2|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 3.0|
Interstitium, Infiltration Cellular | 1 | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 57 |
Thrombosis | 1 | 6 1.0|
Thrombosis, Multiple | X | 1 |
Nasolacrimal Duct, Inflammation | | 4 2.0|
Nasopharyngeal Duct, Hyperplasia, | | |
Lymphoid | | 1 3.0|
Nasopharyngeal Duct, Hyperplasia | 1 | 2 1.5|
Nasopharyngeal Duct, Inflammation | | 4 1.8|
Olfactory Epithelium, Degeneration | 1 1 1 1 | 19 1.0|
Olfactory Epithelium, Necrosis | | 1 1.0|
Respiratory Epithelium, Degeneration | | 1 1.0|
Respiratory Epithelium, Hyperplasia | 1 2 2 | 16 1.6|
Respiratory Epithelium, Inflammation | 2 1 2 | 13 1.6|
Respiratory Epithelium, Metaplasia, | | |
Squamous | | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 57 |
Cyst | | 1 |
Infarct | 2 | 2 2.0|
Inflammation | 2 | 1 2.0|
Nephropathy | 1 3 2 4 4 4 | 50 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 5| 6| 5| | |
DAY ON TEST | 8| 5| 3| 3| 3| 6| 8| 6| | |
| 2| 8| 3| 6| 6| 6| 3| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.12 | 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/M3 | 2| 3| 4| 5| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Pigmentation | 4 | 7 3.1|
__________________________________________________________________________|____________|
Urethra | | 3 |
Calculus Micro Observation Only | | 3 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 58 |
Autolysis | | 1 4.0|
Calculus Micro Observation Only | X | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 99
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| | A |
0.12MGM3 | 4| 6| 6| 6| 7| 7| 7| 8| 9| 9| 0| 0| | L |
LUNG TOX | 3| 2| 3| 8| 0| 8| 9| 0| 2| 9| 0| 7| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + | 5 |
Hyperplasia, Lymphoid | 2 2 2 1 1 | 5 1.6|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 5 |
Hyperplasia, Lymphoid | 1 1 2 2 | 4 1.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Hyperplasia, Macrophage | 1 | 1 1.0|
Inflammation, Chronic Active | 1 1 1 1 | 4 1.0|
Interstitium, Infiltration Cellular | 1 1 2 2 2 | 5 1.6|
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
Respiratory Epithelium, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 100
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| | A |
0.12MGM3 | 4| 6| 6| 6| 7| 7| 7| 8| 9| 9| 0| 0| | L |
LUNG TOX | 3| 2| 3| 8| 0| 8| 9| 0| 2| 9| 0| 7| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
Nephropathy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + | 3 |
Calculus Micro Observation Only | X X X | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 101
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 6| 4| 5| 5| 6| 5| 6| 7| 7| 2| 7| 7| 7| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 9| 0| 0| 3| 9| 5| 2| 3| 4| 3| 3| 7| 2| 3| 3| 3| 0| 1| 3| 3| 3|
| 3| 3| 4| 1| 7| 6| 7| 2| 7| 1| 1| 5| 3| 3| 7| 9| 7| 3| 7| 5| 6| 1| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
MG/M3 | 1| 2| 3| 4| 6| 7| 9| 0| 1| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Autolysis | |
Basophilic Focus | 2 3 1 2 2 1 1 1 1 1 2 1 1 3 2 1 1 2 1|
Clear Cell Focus | |
Congestion | |
Degeneration, Cystic | 2 2 |
Degeneration, Fatty | 3 2 2 1 |
Eosinophilic Focus | 3 3 1|
Fatty Change | 4 |
Hepatodiaphragmatic Nodule | X X X X |
Bile Duct, Hyperplasia | 3 2 2 3 3 2 3 3 3 2 3 2 1 3 4 4 2 3|
Centrilobular, Atrophy | 1 2 2 2 |
Hepatocyte, Hyperplasia | 3 |
Hepatocyte, Necrosis | 2 3 3 2 2 2 2 1 2 2|
__________________________________________________________________________|
Oral Mucosa | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Acinus, Atrophy | 2 2 3 3 |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Ulcer | 2 |
__________________________________________________________________________|
Tooth | + + |
Developmental Malformation | X X |
Peridontal Tissue, Hyperplasia | |
Peridontal Tissue, Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 102
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 6| 4| 5| 5| 6| 5| 6| 7| 7| 2| 7| 7| 7| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 9| 0| 0| 3| 9| 5| 2| 3| 4| 3| 3| 7| 2| 3| 3| 3| 0| 1| 3| 3| 3|
| 3| 3| 4| 1| 7| 6| 7| 2| 7| 1| 1| 5| 3| 3| 7| 9| 7| 3| 7| 5| 6| 1| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
MG/M3 | 1| 2| 3| 4| 6| 7| 9| 0| 1| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Cardiomyopathy | 2 2 1 2 3 2 2 2 2 2 3 3 3 2 |
Proliferation Connective Tissue | 1 |
Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia | 2 1 |
Vacuolization Cytoplasmic | 1 2 2 1 1 2 4 1|
Capsule, Fibrosis | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Hyperplasia | 2 2 1 4 2 4 4 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia | 4 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Pars Distalis, Hyperplasia, Focal | 4 3 2 2 4 2 4 4|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
C-Cell, Hyperplasia | 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + + |
Pelvic, Ectopic Tissue | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Autolysis | |
Ectasia | 2 2 |
Hyperplasia | 2|
Inflammation | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Autolysis | |
_____________________________________________________________________________________________________________________|
Page 103
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 6| 4| 5| 5| 6| 5| 6| 7| 7| 2| 7| 7| 7| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 9| 0| 0| 3| 9| 5| 2| 3| 4| 3| 3| 7| 2| 3| 3| 3| 0| 1| 3| 3| 3|
| 3| 3| 4| 1| 7| 6| 7| 2| 7| 1| 1| 5| 3| 3| 7| 9| 7| 3| 7| 5| 6| 1| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
MG/M3 | 1| 2| 3| 4| 6| 7| 9| 0| 1| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 1 4 |
Germinal Epithelium, Degeneration | |
Interstitial Cell, Hyperplasia, Focal| 2 1 2 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | |
Atrophy | 4 |
Hyperplasia | |
Myeloid Cell, Hyperplasia | 2 4 4 3 3 3 3 3 2 3|
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Pigmentation | |
Inguinal, Hyperplasia, Lymphoid | |
Pancreatic, Inflammation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + M + + + + + M + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 2 4 3 |
Hyperplasia, Plasma Cell | 3 |
Inflammation | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + M + + + + + + + + + M + M + + + + + + +|
Congestion | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Congestion | |
Fibrosis | 3 4 2 3 2 |
Hematopoietic Cell Proliferation | |
Infarct | 4 |
__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + + + + M + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Prepuce, Fibrosis | |
_____________________________________________________________________________________________________________________|
Page 104
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 6| 4| 5| 5| 6| 5| 6| 7| 7| 2| 7| 7| 7| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 9| 0| 0| 3| 9| 5| 2| 3| 4| 3| 3| 7| 2| 3| 3| 3| 0| 1| 3| 3| 3|
| 3| 3| 4| 1| 7| 6| 7| 2| 7| 1| 1| 5| 3| 3| 7| 9| 7| 3| 7| 5| 6| 1| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
MG/M3 | 1| 2| 3| 4| 6| 7| 9| 0| 1| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Sebaceous Gland, Inflammation | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 2 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
Inflammation | 2 1 1 1 2 1 |
Metaplasia, Squamous | 2 |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fibrosis | 2 1 2 1 2 1 1 2 1 1 1 2 2 2 1|
Hemorrhage | |
Hyperplasia, Macrophage | 2 2 1 2 2 1 1 1 1 1 2 |
Inflammation, Chronic Active | 3 2 2 3 2 3 1 1 2 1 2 2 1 2 2 2 2 2 2 3 1|
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 3 1 |
Alveolus, Proteinosis | 1 1 1 2 2 |
Interstitium, Infiltration Cellular | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 1 1 1 |
Thrombosis, Multiple | X X |
Glands, Inflammation | |
Nasolacrimal Duct, Inflammation | 2 |
Nasopharyngeal Duct, Inflammation | |
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Degeneration | 1 1 1 1 1 1 1 1 |
Olfactory Epithelium, Inflammation | 1 |
Olfactory Epithelium, Metaplasia, | |
Squamous | 1 |
Respiratory Epithelium, Degeneration | |
Respiratory Epithelium, Hyperplasia | 2 1 1 2 1 2 3 2 2 3 1 1|
Respiratory Epithelium, Inflammation | 1 1 3 2 3 4 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 1 |
Vomeronasal Organ, Inflammation | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 105
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 6| 4| 5| 5| 6| 5| 6| 7| 7| 2| 7| 7| 7| 5| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 1| 5| 9| 0| 0| 3| 9| 5| 2| 3| 4| 3| 3| 7| 2| 3| 3| 3| 0| 1| 3| 3| 3|
| 3| 3| 4| 1| 7| 6| 7| 2| 7| 1| 1| 5| 3| 3| 7| 9| 7| 3| 7| 5| 6| 1| 2| 3| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
MG/M3 | 1| 2| 3| 4| 6| 7| 9| 0| 1| 4| 5| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Infarct | 4 |
Inflammation | 2 |
Nephropathy | 3 4 3 1 3 1 3 3 1 3 1 1 2 3 4 3 2 3 4 4 4|
Renal Tubule, Pigmentation | 2 4 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X X X |
_____________________________________________________________________________________________________________________|
Page 106
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 4| 5| 7| 4| 5| 6| 7| 4| 7| 4| 6| 7| 6| 7| 4| 7| 4| 7| 7| 6| 5| 6| 6| 4|
DAY ON TEST | 1| 5| 7| 3| 5| 3| 9| 3| 7| 1| 5| 7| 3| 8| 3| 5| 2| 5| 3| 3| 0| 5| 2| 1| 9|
| 7| 8| 6| 3| 8| 8| 7| 6| 1| 3| 8| 9| 7| 3| 7| 8| 5| 8| 6| 6| 1| 0| 8| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4|
MG/M3 | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 6| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + I + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + A + + + + + + + A + + + + + + + A|
Peyer's Patch, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + A + + + + + + + A + + + + M + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Autolysis | 3 3|
Basophilic Focus | 1 1 3 1 1 2 1 1 2 4 2 1 1 3 2 1 1 2 1 |
Clear Cell Focus | 1 1 |
Congestion | 3 3 |
Degeneration, Cystic | 1 2 2 1 1 |
Degeneration, Fatty | 4 2 1 1 |
Eosinophilic Focus | 2 |
Fatty Change | |
Hepatodiaphragmatic Nodule | X |
Bile Duct, Hyperplasia | 2 2 1 4 3 1 2 2 4 2 2 3 1 |
Centrilobular, Atrophy | 2 |
Hepatocyte, Hyperplasia | |
Hepatocyte, Necrosis | 3 3 |
__________________________________________________________________________|
Oral Mucosa | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 4|
Acinus, Atrophy | 2 2 2 |
Acinus, Hyperplasia | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + I + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + M + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
Ulcer | |
__________________________________________________________________________|
Tooth | +|
Developmental Malformation | |
Peridontal Tissue, Hyperplasia | 2|
Peridontal Tissue, Inflammation | 1|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 107
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 4| 5| 7| 4| 5| 6| 7| 4| 7| 4| 6| 7| 6| 7| 4| 7| 4| 7| 7| 6| 5| 6| 6| 4|
DAY ON TEST | 1| 5| 7| 3| 5| 3| 9| 3| 7| 1| 5| 7| 3| 8| 3| 5| 2| 5| 3| 3| 0| 5| 2| 1| 9|
| 7| 8| 6| 3| 8| 8| 7| 6| 1| 3| 8| 9| 7| 3| 7| 8| 5| 8| 6| 6| 1| 0| 8| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4|
MG/M3 | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 6| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Cardiomyopathy | 1 3 3 3 2 2 3 3 3 |
Proliferation Connective Tissue | |
Thrombosis | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hyperplasia | 1 |
Vacuolization Cytoplasmic | 2 2 2 1 2 |
Capsule, Fibrosis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Hyperplasia | 3 2 2 2 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + M|
Hyperplasia | 1 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 4 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 3 1 4 1 |
__________________________________________________________________________|
Thyroid Gland | A + + + + + + + + + + + + + + + + + + + + + + + A|
Autolysis | 4 |
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Pelvic, Ectopic Tissue | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + I + + + + + + + + + +|
Atrophy | 2 |
Autolysis | 3|
Ectasia | 1 |
Hyperplasia | |
Inflammation | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 |
Autolysis | 4|
_____________________________________________________________________________________________________________________|
Page 108
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 4| 5| 7| 4| 5| 6| 7| 4| 7| 4| 6| 7| 6| 7| 4| 7| 4| 7| 7| 6| 5| 6| 6| 4|
DAY ON TEST | 1| 5| 7| 3| 5| 3| 9| 3| 7| 1| 5| 7| 3| 8| 3| 5| 2| 5| 3| 3| 0| 5| 2| 1| 9|
| 7| 8| 6| 3| 8| 8| 7| 6| 1| 3| 8| 9| 7| 3| 7| 8| 5| 8| 6| 6| 1| 0| 8| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4|
MG/M3 | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 6| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 1 4 |
Germinal Epithelium, Degeneration | 2 |
Interstitial Cell, Hyperplasia, Focal| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + A + + + + + + + +|
Atrophy, Focal | 2 2 |
Atrophy | |
Hyperplasia | 4 |
Myeloid Cell, Hyperplasia | 3 1 3 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Iliac, Pigmentation | |
Inguinal, Hyperplasia, Lymphoid | 4 |
Pancreatic, Inflammation | 1 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + I + + + + M + + + + A|
Hyperplasia, Lymphoid | 1 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 4 1 1 |
Hyperplasia, Plasma Cell | 4 3 1 |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + A + + + M + + + + + + + + M + + +|
Congestion | 3 3 4|
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Macrophage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + A + + + + + + + + + + + + + + + A|
Atrophy | 2 |
Congestion | 2 |
Fibrosis | 1 3 1 2 4 2 |
Hematopoietic Cell Proliferation | 2 |
Infarct | |
__________________________________________________________________________|
Thymus | + + + M + + + + A + + + + + + + + + M + + + + + A|
Atrophy | 3 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + I + + + M + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Prepuce, Fibrosis | |
_____________________________________________________________________________________________________________________|
Page 109
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 4| 5| 7| 4| 5| 6| 7| 4| 7| 4| 6| 7| 6| 7| 4| 7| 4| 7| 7| 6| 5| 6| 6| 4|
DAY ON TEST | 1| 5| 7| 3| 5| 3| 9| 3| 7| 1| 5| 7| 3| 8| 3| 5| 2| 5| 3| 3| 0| 5| 2| 1| 9|
| 7| 8| 6| 3| 8| 8| 7| 6| 1| 3| 8| 9| 7| 3| 7| 8| 5| 8| 6| 6| 1| 0| 8| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4|
MG/M3 | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 6| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Sebaceous Gland, Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | |
Hemorrhage | 4|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
Inflammation | 2 2 1 1 1 |
Metaplasia, Squamous | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 3|
Fibrosis | 3 1 1 1 2 2 1 3 2 3 2 1 1 |
Hemorrhage | 2 |
Hyperplasia, Macrophage | 1 2 3 2 2 1 3 4 1 1 2 1 2 1 2 1 2 1 1 1|
Inflammation, Chronic Active | 2 2 1 1 2 1 2 3 1 1 2 2 2 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
Alveolus, Proteinosis | 2 1 1 2 1 1 1 |
Interstitium, Infiltration Cellular | 1 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 1 |
Thrombosis, Multiple | X |
Glands, Inflammation | 1 |
Nasolacrimal Duct, Inflammation | 2 |
Nasopharyngeal Duct, Inflammation | 2 1 |
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Degeneration | 1 1 1 1 |
Olfactory Epithelium, Inflammation | |
Olfactory Epithelium, Metaplasia, | |
Squamous | |
Respiratory Epithelium, Degeneration | 1 |
Respiratory Epithelium, Hyperplasia | 2 1 1 2 1 3 3 2 1 3 2 1 |
Respiratory Epithelium, Inflammation | 4 1 3 1 3 4 1 1 1 2 1 |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
Vomeronasal Organ, Inflammation | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 110
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
_____________________________________________________________________________________________________________________
| 7| 4| 5| 7| 4| 5| 6| 7| 4| 7| 4| 6| 7| 6| 7| 4| 7| 4| 7| 7| 6| 5| 6| 6| 4|
DAY ON TEST | 1| 5| 7| 3| 5| 3| 9| 3| 7| 1| 5| 7| 3| 8| 3| 5| 2| 5| 3| 3| 0| 5| 2| 1| 9|
| 7| 8| 6| 3| 8| 8| 7| 6| 1| 3| 8| 9| 7| 3| 7| 8| 5| 8| 6| 6| 1| 0| 8| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.25 | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4|
MG/M3 | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 1| 2| 3| 4| 6| 7| 9| 1| 2|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | |
Cataract | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + A|
Autolysis | 4 3 |
Infarct | 4 |
Inflammation | |
Nephropathy | 1 2 4 2 3 4 3 1 2 4 3 4 2 4 2 4 2 1 2 1 |
Renal Tubule, Pigmentation | 1 3 4 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X X X |
_____________________________________________________________________________________________________________________|
Page 111
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 6| | |
DAY ON TEST | 3| 5| 3| 3| 3| 8| 2| 8| | |
| 7| 1| 6| 3| 7| 4| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25 | 4| 4| 4| 4| 4| 4| 4| 5| | L |
MG/M3 | 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 58 |
Autolysis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + | 57 |
Autolysis | | 1 3.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 58 |
Autolysis | | 1 3.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 55 |
Peyer's Patch, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 58 |
Angiectasis | 1 | 4 1.5|
Autolysis | | 2 3.0|
Basophilic Focus | 2 2 1 2 1 1 2 2 | 46 1.6|
Clear Cell Focus | | 2 1.0|
Congestion | | 2 3.0|
Degeneration, Cystic | | 7 1.6|
Degeneration, Fatty | 2 3 1 1 | 12 1.9|
Eosinophilic Focus | 1 | 5 2.0|
Fatty Change | | 1 4.0|
Hepatodiaphragmatic Nodule | X | 6 |
Bile Duct, Hyperplasia | 2 2 2 3 2 1 | 37 2.4|
Centrilobular, Atrophy | | 5 1.8|
Hepatocyte, Hyperplasia | | 1 3.0|
Hepatocyte, Necrosis | | 12 2.3|
__________________________________________________________________________|____________|
Oral Mucosa | + | 4 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 58 |
Autolysis | | 2 3.5|
Acinus, Atrophy | 3 4 | 9 2.6|
Acinus, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 57 |
Ulcer | 3 | 2 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 58 |
Necrosis | | 1 2.0|
Ulcer | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 112
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 6| | |
DAY ON TEST | 3| 5| 3| 3| 3| 8| 2| 8| | |
| 7| 1| 6| 3| 7| 4| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25 | 4| 4| 4| 4| 4| 4| 4| 5| | L |
MG/M3 | 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tooth | | 3 |
Developmental Malformation | | 2 |
Peridontal Tissue, Hyperplasia | | 1 2.0|
Peridontal Tissue, Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 58 |
Autolysis | | 1 3.0|
Cardiomyopathy | 2 2 2 2 1 2 | 29 2.2|
Proliferation Connective Tissue | | 1 1.0|
Thrombosis | | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 58 |
Autolysis | | 1 3.0|
Hyperplasia | 1 | 4 1.3|
Vacuolization Cytoplasmic | 2 1 3 1 | 17 1.8|
Capsule, Fibrosis | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 58 |
Autolysis | | 1 3.0|
Hyperplasia | 2 2 1 | 18 2.3|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 57 |
Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 56 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 58 |
Angiectasis | | 3 3.0|
Pars Distalis, Hyperplasia, Focal | 2 | 16 2.6|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 56 |
Autolysis | | 1 4.0|
C-Cell, Hyperplasia | 2 3 | 8 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 5 |
Pelvic, Ectopic Tissue | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + | 57 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 113
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 6| | |
DAY ON TEST | 3| 5| 3| 3| 3| 8| 2| 8| | |
| 7| 1| 6| 3| 7| 4| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.25 | 4| 4| 4| 4| 4| 4| 4| 5| | L |
MG/M3 | 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Atrophy | | 2 1.5|
Autolysis | | 1 3.0|
Ectasia | 2 4 | 5 2.2|
Hyperplasia | | 1 2.0|
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + | 58 |
Inflammation | | 4 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + | 58 |
Atrophy | 2 1 2 | 7 1.7|
Autolysis | | 1 4.0|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + | 58 |
Atrophy | 4 3 2 | 10 3.0|
Germinal Epithelium, Degeneration | | 1 2.0|
Interstitial Cell, Hyperplasia, Focal| 1 | 6 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 57 |
Atrophy, Focal | | 2 2.0|
Atrophy | | 1 4.0|
Hyperplasia | | 1 4.0|
Myeloid Cell, Hyperplasia | 3 1 3 | 18 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + | 11 |
Iliac, Pigmentation | 2 | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | | 1 4.0|
Pancreatic, Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + I | 52 |
Hyperplasia, Lymphoid | 2 | 4 2.0|
Hyperplasia, Plasma Cell | 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + I + + + + | 56 |
Hyperplasia, Lymphoid | 2 | 9 2.6|
Hyperplasia, Plasma Cell | 2 3 | 6 2.7|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 58 |
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + | 51 |
Congestion | | 3 3.3|
Hyperplasia, Lymphoid | 2 2 | 5 2.0|
Hyperplasia, Macrophage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 114
NTP Experiment-Test: 05122-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SULFATE HEXAHYDRATE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 10:40:46
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 6|