TDMS Study 05123-06 Pathology Tables
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
CORE ANIMALS
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 1313-99-1
Lock Date: 04/19/94
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25026 Other
25006 Terminal Sacrifice 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Exclude 003 O MG/M3 LUNGTX
Exclude 004 0 MG/M3 LUNGTX
Exclude 007 1.25MGM3 LUNGTX
Exclude 008 1.25MGM3 LUNGTX
Exclude 011 2.5MG/M3 LUNGTX
Exclude 012 2.5MG/M3 LUNGTX
Exclude 015 5.0MG/M3 LUNGTX
Exclude 016 5.0MG/M3 LUNGTX
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 5| 7| 5| 1| 7| 6| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 1| 0| 6| 3| 7| 7| 7| 5|
DAY ON TEST | 1| 3| 9| 1| 2| 3| 3| 3| 3| 1| 2| 3| 2| 9| 3| 3| 3| 3| 2| 4| 5| 3| 3| 2| 5|
| 0| 0| 9| 7| 9| 8| 2| 0| 6| 4| 8| 0| 9| 5| 0| 3| 2| 2| 9| 2| 7| 2| 3| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 6| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + A + + + + + M|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + M + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + M + + + + M +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple, | |
Multiple | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X |
__________________________________________________________________________|
Mesentery | + |
Hemangiosarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | X X |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M M + + + + M + + M + + M + M + + + + + + M|
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 5| 7| 5| 1| 7| 6| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 1| 0| 6| 3| 7| 7| 7| 5|
DAY ON TEST | 1| 3| 9| 1| 2| 3| 3| 3| 3| 1| 2| 3| 2| 9| 3| 3| 3| 3| 2| 4| 5| 3| 3| 2| 5|
| 0| 0| 9| 7| 9| 8| 2| 0| 6| 4| 8| 0| 9| 5| 0| 3| 2| 2| 9| 2| 7| 2| 3| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 6| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Pars Distalis, Adenoma | |
Pars Distalis, Carcinoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
Follicular Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Thoracic, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + M + I + + I + + M + + + + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + I + + +|
Cystadenoma | |
Lymphoma Malignant | |
Teratoma Benign | X |
Thecoma Benign | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Leiomyoma | |
Polyp Stromal | X|
Sarcoma Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Axillary, Hemangiosarcoma | X |
Iliac, Lymphoma Malignant | X X X X X X |
Inguinal, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant | X X |
Renal, Lymphoma Malignant | X X X X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + I I + + + + + M + + + + + + + M + + M + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Lymphoma Malignant | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
Lymphoma Malignant | X X X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + M A + + + + + +|
Lymphoma Malignant | X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M + + + M M M + + + + + + + M M M M + + + +|
Alveolar/Bronchiolar Carcinoma, | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 5| 7| 5| 1| 7| 6| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 1| 0| 6| 3| 7| 7| 7| 5|
DAY ON TEST | 1| 3| 9| 1| 2| 3| 3| 3| 3| 1| 2| 3| 2| 9| 3| 3| 3| 3| 2| 4| 5| 3| 3| 2| 5|
| 0| 0| 9| 7| 9| 8| 2| 0| 6| 4| 8| 0| 9| 5| 0| 3| 2| 2| 9| 2| 7| 2| 3| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 6| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Metastatic, Lung | |
Lymphoma Malignant | X X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant | X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + M + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
__________________________________________________________________________|
Skin | + + |
Subcutaneous Tissue, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Lymphoma Malignant | |
Rhabdomyosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | |
Basosquamous Tumor Malignant, | |
Metastatic, Ear | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant | X X X X |
__________________________________________________________________________|
Nose | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 5| 7| 5| 1| 7| 6| 7| 7| 7| 0| 7| 7| 7| 6| 7| 7| 7| 1| 0| 6| 3| 7| 7| 7| 5|
DAY ON TEST | 1| 3| 9| 1| 2| 3| 3| 3| 3| 1| 2| 3| 2| 9| 3| 3| 3| 3| 2| 4| 5| 3| 3| 2| 5|
| 0| 0| 9| 7| 9| 8| 2| 0| 6| 4| 8| 0| 9| 5| 0| 3| 2| 2| 9| 2| 7| 2| 3| 8| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
| 1| 2| 3| 6| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 5| 6| 9| 0| 1| 2| 3| 4|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Ear | + |
Basosquamous Tumor Malignant | X |
External Ear, Fibrosarcoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 1| 3| 3| 9| 8| 3| 3| 2| 2| 3| 3| 3|
| 9| 6| 2| 2| 1| 0| 3| 3| 9| 6| 2| 2| 2| 8| 1| 0| 4| 8| 1| 0| 9| 2| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 5| 6| 8| 9| 1| 3| 4| 6| 7| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + M + + + + + M A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + M + + + A + + + + + + + + A + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple, | |
Multiple | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Mesentery | + |
Hemangiosarcoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + M + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | I + + + + + + + + + + + + + + + I + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 1| 3| 3| 9| 8| 3| 3| 2| 2| 3| 3| 3|
| 9| 6| 2| 2| 1| 0| 3| 3| 9| 6| 2| 2| 2| 8| 1| 0| 4| 8| 1| 0| 9| 2| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 5| 6| 8| 9| 1| 3| 4| 6| 7| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X |
Pars Distalis, Carcinoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
Follicular Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Thoracic, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + M + + + M +|
Cystadenoma | X |
Lymphoma Malignant | |
Teratoma Benign | |
Thecoma Benign | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Leiomyoma | X |
Polyp Stromal | |
Sarcoma Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node | + + + + + |
Axillary, Hemangiosarcoma | |
Iliac, Lymphoma Malignant | X X |
Inguinal, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant | X X |
Renal, Lymphoma Malignant | X X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + I + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M + + + + + + + + M M + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + M M M + M M + + + M M + M + + M M M + + +|
Alveolar/Bronchiolar Carcinoma, | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 1| 3| 3| 9| 8| 3| 3| 2| 2| 3| 3| 3|
| 9| 6| 2| 2| 1| 0| 3| 3| 9| 6| 2| 2| 2| 8| 1| 0| 4| 8| 1| 0| 9| 2| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 5| 6| 8| 9| 1| 3| 4| 6| 7| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Metastatic, Lung | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + I + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Carcinoma | X |
__________________________________________________________________________|
Skin | + + |
Subcutaneous Tissue, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Lymphoma Malignant | |
Rhabdomyosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + M + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X X X |
Basosquamous Tumor Malignant, | |
Metastatic, Ear | |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 3| 3| 3| 2| 8| 3| 3| 3| 1| 3| 3| 9| 8| 3| 3| 2| 2| 3| 3| 3|
| 9| 6| 2| 2| 1| 0| 3| 3| 9| 6| 2| 2| 2| 8| 1| 0| 4| 8| 1| 0| 9| 2| 0| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 MG/M3 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 5| 6| 8| 9| 1| 3| 4| 6| 7| 8| 9| 0| 1| 4| 5| 6| 7| 8| 9| 1| 2| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Ear | + |
Basosquamous Tumor Malignant | |
External Ear, Fibrosarcoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 2| 2| 4| 3| 3| 3| 3| | |
| 6| 3| 1| 9| 9| 9| 1| 1| 6| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/M3 | 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + M + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 55 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hepatocellular Carcinoma | | 7 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X | 5 |
Hepatocellular Adenoma, Multiple, | | |
Multiple | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X | 7 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Squamous Cell Carcinoma | X | 1 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Tooth | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 2| 2| 4| 3| 3| 3| 3| | |
| 6| 3| 1| 9| 9| 9| 1| 1| 6| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/M3 | 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Pheochromocytoma Malignant | | 2 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Adenoma | X | 6 |
Pars Distalis, Carcinoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Follicular Cell, Adenoma | X | 2 |
Follicular Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Thoracic, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 57 |
Cystadenoma | | 1 |
Lymphoma Malignant | X | 1 |
Teratoma Benign | | 1 |
Thecoma Benign | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
Leiomyoma | | 1 |
Polyp Stromal | X | 2 |
Sarcoma Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 15 |
Axillary, Hemangiosarcoma | | 1 |
Iliac, Lymphoma Malignant | X X | 10 |
Inguinal, Lymphoma Malignant | X | 2 |
Pancreatic, Lymphoma Malignant | X X | 6 |
Renal, Lymphoma Malignant | X X | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 2| 2| 4| 3| 3| 3| 3| | |
| 6| 3| 1| 9| 9| 9| 1| 1| 6| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/M3 | 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + I + + + + | 53 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Lymphoma Malignant | X X | 11 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Lymphoma Malignant | X X | 9 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + M + + + + | 53 |
Lymphoma Malignant | X X | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + M + + M M | 35 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Lymphoma Malignant | X X | 9 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hemangiosarcoma | | 2 |
Lymphoma Malignant | X X | 9 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 2 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X X | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 59 |
Carcinoma | X | 2 |
__________________________________________________________________________|____________|
Skin | | 4 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Lymphoma Malignant | X | 1 |
Rhabdomyosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Carcinoma, Metastatic | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 3| 2| 2| 4| 3| 3| 3| 3| | |
| 6| 3| 1| 9| 9| 9| 1| 1| 6| 0| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 MG/M3 | 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 9| 0| 1| 2| 3| 4| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + M + + | 58 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | | 2 |
Alveolar/Bronchiolar Carcinoma | X | 4 |
Basosquamous Tumor Malignant, | | |
Metastatic, Ear | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant | X | 6 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
Basosquamous Tumor Malignant | | 1 |
External Ear, Fibrosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Lymphoma Malignant | X X | 6 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Lymphoma Malignant | X | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 2 |
Lymphoma Malignant | X X | 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 3| 3| 3| 2| 2| 9| 0| 3| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 3|
| 2| 6| 1| 1| 3| 0| 1| 9| 9| 5| 9| 3| 9| 9| 1| 3| 3| 2| 0| 2| 0| 6| 4| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
| 1| 4| 5| 6| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + A + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + M + + + A + M + + M + M + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + A + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + A + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + M + A + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Multiple | |
Hemangiosarcoma, Metastatic, Uterus | |
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X X |
Lymphoma Malignant | |
__________________________________________________________________________|
Mesentery | + + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + I + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 14
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 3| 3| 3| 2| 2| 9| 0| 3| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 3|
| 2| 6| 1| 1| 3| 0| 1| 9| 9| 5| 9| 3| 9| 9| 1| 3| 3| 2| 0| 2| 0| 6| 4| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
| 1| 4| 5| 6| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | I + + + + + + M + + + + + + + + + + + + + + + + +|
Duct, Adenoma | X |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Hemangiosarcoma | |
Polyp Stromal | X X X|
Cervix, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + |
Axillary, Lymphoma Malignant | |
Deep Cervical, Lymphoma Malignant | |
Iliac, Lymphoma Malignant | |
Inguinal, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant | |
Renal, Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + I + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + M + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + I + M + + M M M + + M I + + + + M + + M + M +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 15
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 3| 3| 3| 2| 2| 9| 0| 3| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 3|
| 2| 6| 1| 1| 3| 0| 1| 9| 9| 5| 9| 3| 9| 9| 1| 3| 3| 2| 0| 2| 0| 6| 4| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
| 1| 4| 5| 6| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + M + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X X X |
__________________________________________________________________________|
Skin | + |
Hemangiosarcoma | |
Melanoma NOS | |
Subcutaneous Tissue, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | I + + + + + + + + + + + + + + + + + + + + I + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X|
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X |
Alveolar/Bronchiolar Carcinoma | X X X |
Hepatocellular Carcinoma, Metastatic | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 6| 3| 3| 3| 3| 3| 2| 2| 9| 0| 3| 2| 6| 3| 3| 3| 3| 3| 3| 3| 3| 4| 2| 3|
| 2| 6| 1| 1| 3| 0| 1| 9| 9| 5| 9| 3| 9| 9| 1| 3| 3| 2| 0| 2| 0| 6| 4| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
| 1| 4| 5| 6| 8| 9| 0| 1| 3| 4| 6| 7| 8| 9| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Lymphoma Malignant | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 2| 7| 6| 3| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 7| 8| 3| 2| 3| 3| 3| 3| 2| 0| 9| 3| 8| 0| 3| 8| 1| 3| 3| 1| 3| 3| 3| 5|
| 0| 6| 3| 1| 9| 1| 6| 0| 2| 6| 3| 0| 0| 3| 3| 1| 3| 7| 2| 2| 1| 0| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
1.25MGM3 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0|
| 5| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 3| 4|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + A + + + + + + + + + + A|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + M M + M M + M + + + M + + + + + + + + + + M +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + A|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + A|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + A|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + M + + + A|
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Multiple | X |
Hemangiosarcoma, Metastatic, Uterus | |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Adenoma | X X X |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
Lymphoma Malignant | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
Lymphoma Malignant | X |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + M + + M + M M + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X|
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 2| 7| 6| 3| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 7| 8| 3| 2| 3| 3| 3| 3| 2| 0| 9| 3| 8| 0| 3| 8| 1| 3| 3| 1| 3| 3| 3| 5|
| 0| 6| 3| 1| 9| 1| 6| 0| 2| 6| 3| 0| 0| 3| 3| 1| 3| 7| 2| 2| 1| 0| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
1.25MGM3 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0|
| 5| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 3| 4|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + M + + + + + + + + + + + + + + M + + + + +|
Duct, Adenoma | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Hemangiosarcoma | |
Polyp Stromal | X |
Cervix, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + |
Axillary, Lymphoma Malignant | X |
Deep Cervical, Lymphoma Malignant | X |
Iliac, Lymphoma Malignant | X |
Inguinal, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant | X X X X |
Renal, Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + M + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + I|
Lymphoma Malignant | X X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + + M + M I M I + + + M + M M I + M M M M + I M|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic | X |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 2| 7| 6| 3| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 7| 8| 3| 2| 3| 3| 3| 3| 2| 0| 9| 3| 8| 0| 3| 8| 1| 3| 3| 1| 3| 3| 3| 5|
| 0| 6| 3| 1| 9| 1| 6| 0| 2| 6| 3| 0| 0| 3| 3| 1| 3| 7| 2| 2| 1| 0| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
1.25MGM3 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0|
| 5| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 3| 4|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + M I + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic | X |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
__________________________________________________________________________|
Skin | + + + + |
Hemangiosarcoma | |
Melanoma NOS | X |
Subcutaneous Tissue, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + I + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + I + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X|
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X X X X |
Hepatocellular Carcinoma, Metastatic | |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 5| 2| 7| 6| 3| 7| 7| 7| 7| 7| 7| 6|
DAY ON TEST | 4| 7| 8| 3| 2| 3| 3| 3| 3| 2| 0| 9| 3| 8| 0| 3| 8| 1| 3| 3| 1| 3| 3| 3| 5|
| 0| 6| 3| 1| 9| 1| 6| 0| 2| 6| 3| 0| 0| 3| 3| 1| 3| 7| 2| 2| 1| 0| 3| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
1.25MGM3 | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0|
| 5| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 3| 4|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Lymphoma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| | |
DAY ON TEST | 9| 3| 3| 3| 2| 3| 2| 1| 3| 3| | |
| 2| 3| 1| 0| 9| 3| 0| 0| 3| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25MGM3 | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | L |
| 6| 7| 1| 2| 3| 4| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 56 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 58 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M + + + + + + | 47 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 57 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 56 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 54 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hemangiosarcoma, Multiple | | 1 |
Hemangiosarcoma, Metastatic, Uterus | X | 1 |
Hepatocellular Carcinoma | X X X | 10 |
Hepatocellular Adenoma | X X | 7 |
Lymphoma Malignant | X | 3 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| | |
DAY ON TEST | 9| 3| 3| 3| 2| 3| 2| 1| 3| 3| | |
| 2| 3| 1| 0| 9| 3| 0| 0| 3| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25MGM3 | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | L |
| 6| 7| 1| 2| 3| 4| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + | 51 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Adenoma | X | 8 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 56 |
Duct, Adenoma | | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Carcinoma | | 1 |
Hemangiosarcoma | X | 1 |
Polyp Stromal | | 4 |
Cervix, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + | 8 |
Axillary, Lymphoma Malignant | | 1 |
Deep Cervical, Lymphoma Malignant | | 1 |
Iliac, Lymphoma Malignant | X | 2 |
Inguinal, Lymphoma Malignant | | 1 |
Pancreatic, Lymphoma Malignant | X | 5 |
Renal, Lymphoma Malignant | X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 58 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 2 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 58 |
Lymphoma Malignant | | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| | |
DAY ON TEST | 9| 3| 3| 3| 2| 3| 2| 1| 3| 3| | |
| 2| 3| 1| 0| 9| 3| 0| 0| 3| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25MGM3 | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | L |
| 6| 7| 1| 2| 3| 4| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant | X X | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M I M + I M + M M + | 27 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Lymphoma Malignant | X | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hemangiosarcoma | X | 2 |
Lymphoma Malignant | X X | 3 |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 55 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic | | 1 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
Lymphoma Malignant | X X | 4 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Adenoma | | 1 |
Carcinoma | | 3 |
__________________________________________________________________________|____________|
Skin | + | 6 |
Hemangiosarcoma | X | 1 |
Melanoma NOS | | 1 |
Subcutaneous Tissue, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| | |
DAY ON TEST | 9| 3| 3| 3| 2| 3| 2| 1| 3| 3| | |
| 2| 3| 1| 0| 9| 3| 0| 0| 3| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.25MGM3 | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| | L |
| 6| 7| 1| 2| 3| 4| 6| 7| 8| 9| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | | 2 |
Alveolar/Bronchiolar Carcinoma | X X X | 10 |
Hepatocellular Carcinoma, Metastatic | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + M + + + | 58 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Lymphoma Malignant | X X | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 3| 6| 5| 5| 5| 7| 7| 5| 3| 3| 7| 0| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 5| 3| 1| 4| 7| 3| 8| 3| 2| 8| 2| 2| 2| 1| 3| 3| 3| 7| 3| 3|
| 9| 1| 3| 6| 2| 1| 3| 5| 0| 0| 8| 4| 2| 9| 7| 1| 6| 9| 9| 6| 6| 0| 0| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 7| 8| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + A + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + M M + + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Mesentery | |
Lymphoma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + M + M + M M + + + + + + M M + + M + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Pars Distalis, Adenoma | X X X |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Fat, Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 3| 6| 5| 5| 5| 7| 7| 5| 3| 3| 7| 0| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 5| 3| 1| 4| 7| 3| 8| 3| 2| 8| 2| 2| 2| 1| 3| 3| 3| 7| 3| 3|
| 9| 1| 3| 6| 2| 1| 3| 5| 0| 0| 8| 4| 2| 9| 7| 1| 6| 9| 9| 6| 6| 0| 0| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 7| 8| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + I + + + M + + + + + + + + + + + + + I M|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + M + +|
Cystadenoma | |
Granulosa-Theca Tumor Benign | |
Lymphoma Malignant | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hemangiosarcoma | |
Lymphoma Malignant | |
Sarcoma Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hemangiosarcoma, Metastatic, Spleen | X |
__________________________________________________________________________|
Lymph Node | + + + + + +|
Axillary, Hemangiosarcoma | X |
Iliac, Lymphoma Malignant | X X|
Pancreatic, Lymphoma Malignant | X X |
Renal, Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + I + + + + + + + + + + +|
Lymphoma Malignant | X X X X X|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + M + M + + + + + + + +|
Lymphoma Malignant | X X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + M + + + + M + + + + + + M +|
Hemangiosarcoma, Metastatic, Liver | X |
Lymphoma Malignant | X|
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + I + + + M + + + M M + I + + + M + + M + + +|
Lymphoma Malignant | X X X|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X X X |
Lymphoma Malignant | X X X X X X|
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + |
Sarcoma | X |
Sebaceous Gland, Adenoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 3| 6| 5| 5| 5| 7| 7| 5| 3| 3| 7| 0| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 3| 5| 3| 1| 4| 7| 3| 8| 3| 2| 8| 2| 2| 2| 1| 3| 3| 3| 7| 3| 3|
| 9| 1| 3| 6| 2| 1| 3| 5| 0| 0| 8| 4| 2| 9| 7| 1| 6| 9| 9| 6| 6| 0| 0| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 7| 8| 9| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X X |
Hepatocellular Carcinoma, Metastatic | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Fibrosarcoma | X |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X X X X|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 8| 3| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 2|
| 9| 3| 9| 1| 3| 6| 2| 0| 9| 9| 0| 1| 9| 0| 2| 0| 8| 1| 0| 1| 1| 9| 0| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|
| 0| 1| 2| 4| 5| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M M + + A + + + + + + + + M M A M + M + + M + M|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + A + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + A + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + A + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + A + + + + + + + + + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X X |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Mesentery | + |
Lymphoma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Tooth | +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + M + + + + + + + + + + + M + M + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Fat, Hemangiosarcoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 8| 3| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 2|
| 9| 3| 9| 1| 3| 6| 2| 0| 9| 9| 0| 1| 9| 0| 2| 0| 8| 1| 0| 1| 1| 9| 0| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|
| 0| 1| 2| 4| 5| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M M + + + +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | X X X |
Granulosa-Theca Tumor Benign | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hemangiosarcoma | X |
Lymphoma Malignant | X |
Sarcoma Stromal | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hemangiosarcoma, Metastatic, Spleen | |
__________________________________________________________________________|
Lymph Node | + + + |
Axillary, Hemangiosarcoma | |
Iliac, Lymphoma Malignant | X X |
Pancreatic, Lymphoma Malignant | X |
Renal, Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + + + + + + + + + + M + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + M + + + + + + + +|
Hemangiosarcoma, Metastatic, Liver | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + + M + + M M M M + M M M M I M M + + M M + M M +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + I + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + |
Sarcoma | |
Sebaceous Gland, Adenoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 2| 8| 3| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 3| 5| 3| 3| 3| 3| 2| 3| 3| 2|
| 9| 3| 9| 1| 3| 6| 2| 0| 9| 9| 0| 1| 9| 0| 2| 0| 8| 1| 0| 1| 1| 9| 0| 6| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
2.5MG/M3 | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|
| 0| 1| 2| 4| 5| 7| 8| 0| 1| 2| 3| 4| 6| 7| 8| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X X |
Alveolar/Bronchiolar Carcinoma | X X |
Hepatocellular Carcinoma, Metastatic | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Fibrosarcoma | |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 0| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 5| 3| 3| 6| 3| 3| 3| 2| | |
| 6| 9| 9| 2| 3| 9| 0| 3| 3| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.5MG/M3 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| | L |
| 3| 5| 6| 8| 9| 0| 2| 3| 8| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + M M M M | 40 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + | 53 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 59 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | X | 6 |
Hepatocellular Adenoma | X | 7 |
Hepatocellular Adenoma, Multiple | | 1 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + A + + + + + + + | 58 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Glandular | + A + + + + + + + | 58 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + | 59 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + | 59 |
Pheochromocytoma Benign | | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + | 58 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + | 45 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 57 |
Pars Distalis, Adenoma | X | 8 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 59 |
Bilateral, Follicular Cell, Adenoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 0| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 5| 3| 3| 6| 3| 3| 3| 2| | |
| 6| 9| 9| 2| 3| 9| 0| 3| 3| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.5MG/M3 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| | L |
| 3| 5| 6| 8| 9| 0| 2| 3| 8| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Fat, Hemangiosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Ovary | + M + + + + + + + | 57 |
Cystadenoma | | 3 |
Granulosa-Theca Tumor Benign | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Uterus | + A + + + + + + + | 58 |
Hemangioma | | 1 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant | | 1 |
Sarcoma Stromal | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 58 |
Hemangiosarcoma | X | 1 |
Hemangiosarcoma, Metastatic, Spleen | | 1 |
__________________________________________________________________________|____________|
Lymph Node | | 9 |
Axillary, Hemangiosarcoma | | 1 |
Iliac, Lymphoma Malignant | | 4 |
Pancreatic, Lymphoma Malignant | | 3 |
Renal, Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + | 56 |
Lymphoma Malignant | | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + A + + M + + + + | 55 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + A + + + + + M + | 51 |
Hemangiosarcoma, Metastatic, Liver | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + I + M + + M M | 31 |
Lymphoma Malignant | | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 59 |
Hemangiosarcoma | X | 5 |
Lymphoma Malignant | | 7 |
__________________________________________________________________________|____________|
Thymus | + + + + + + M + + | 57 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 33
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 0| 6| 7| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 3| 5| 5| 3| 3| 6| 3| 3| 3| 2| | |
| 6| 9| 9| 2| 3| 9| 0| 3| 3| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.5MG/M3 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| | L |
| 3| 5| 6| 8| 9| 0| 2| 3| 8| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymphoma Malignant | | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Skin | + | 5 |
Sarcoma | | 1 |
Sebaceous Gland, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 59 |
Alveolar/Bronchiolar Adenoma | X X X | 10 |
Alveolar/Bronchiolar Carcinoma | | 4 |
Hepatocellular Carcinoma, Metastatic | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
Fibrosarcoma | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 59 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + + + + | 56 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + | 59 |
Lymphoma Malignant | | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 2| 3| 3| 3| 9| 9| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|
| 3| 0| 2| 9| 2| 1| 1| 5| 9| 1| 3| 1| 1| 2| 0| 1| 6| 2| 1| 6| 3| 3| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + A + + + A + + + + + + + + + +|
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Intestine Large, Rectum | + M M + + + + + + + + + + + A M + + + + + M + M M|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + A + + + A + + + + + + + + + +|
Leiomyosarcoma | X |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + A + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + A + + + A + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X |
Hepatocholangiocarcinoma | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X X |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Mesentery | |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Sarcoma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant | X |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant | X |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Tooth | +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 2| 3| 3| 3| 9| 9| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|
| 3| 0| 2| 9| 2| 1| 1| 5| 9| 1| 3| 1| 1| 2| 0| 1| 6| 2| 1| 6| 3| 3| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Odontoma | X|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + I + + + + + + + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X |
Pars Distalis, Carcinoma | |
Pars Intermedia, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + M + + + + M + + M +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
Sarcoma, Metastatic, Mesentery | |
Teratoma Malignant | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Polyp Stromal | X |
Sarcoma, Metastatic, Mesentery | |
Teratoma Malignant, Metastatic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node | + + + + + |
Iliac, Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 2| 3| 3| 3| 9| 9| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|
| 3| 0| 2| 9| 2| 1| 1| 5| 9| 1| 3| 1| 1| 2| 0| 1| 6| 2| 1| 6| 3| 3| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Histiocytic Sarcoma | |
Pancreatic, Lymphoma Malignant | X |
Pancreatic, Sarcoma, Metastatic, | |
Mesentery | |
Renal, Lymphoma Malignant | X X |
Renal, Sarcoma, Metastatic, Mesentery| |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + + + +|
Hemangioma | |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant | X X X X |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + I + + M + I + + M M + M + + M M + I + M M M + I|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X X |
Sarcoma, Metastatic, Mesentery | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + M + M + + + + M I + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X |
Sarcoma, Metastatic, Mesentery | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Skin | + + + + + |
Sarcoma | X |
Squamous Cell Papilloma | |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 2| 3| 3| 3| 9| 9| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|
| 3| 0| 2| 9| 2| 1| 1| 5| 9| 1| 3| 1| 1| 2| 0| 1| 6| 2| 1| 6| 3| 3| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Lymphoma | |
Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant | X |
Sarcoma, Metastatic, Mesentery | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Hypothalamus, Carcinoma, Metastatic | |
Pons, Carcinoma, Metastatic | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X X |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X |
Sarcoma, Metastatic, Mesentery | |
Teratoma Malignant, Metastatic | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + |
Adenoma | X X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant | X X X X X |
Teratoma Malignant, Metastatic | |
__________________________________________________________________________|
Urinary Bladder | + + + + + M + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 2| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 0| 2| 3| 3| 3| 9| 9| 3| 1| 3| 3| 3| 2| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|
| 3| 0| 2| 9| 2| 1| 1| 5| 9| 1| 3| 1| 1| 2| 0| 1| 6| 2| 1| 6| 3| 3| 6| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9|
_____________________________________________________________________________________________________________________|
Sarcoma, Metastatic, Mesentery | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | |
Lymphoma Malignant | X X X X X X |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 0| 7| 6| 7| 1| 6| 5| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 3| 2| 4| 7| 3| 7| 3| 7| 3| 4| 7| 9| 3| 2| 1| 2| 3| 1| 3| 3| 8| 3| 8| 3| 3|
| 3| 9| 4| 3| 1| 0| 2| 0| 1| 1| 5| 7| 1| 6| 0| 9| 2| 9| 1| 0| 4| 3| 4| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0MG/M3 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 0| 2| 3| 4| 6| 9| 0| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 6| 9| 2| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + A + + + A + + + + + + + A + +|
Sarcoma, Metastatic, Mesentery | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + A + + + + + + + A + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + M A + + + A M M + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + A + + + + + + + A + +|
Leiomyosarcoma | |
Sarcoma, Metastatic, Mesentery | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + A + + + + + + + A + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + A + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + M + + + + + A + + + A + + + + + + + A + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X X |
Hepatocholangiocarcinoma | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
Sarcoma, Metastatic, Mesentery | X |
__________________________________________________________________________|
Mesentery | + + |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Sarcoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant | |
Sarcoma, Metastatic, Mesentery | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + A + + + A + + + + + + + + + +|
Sarcoma, Metastatic, Mesentery | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + A + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant | |
Sarcoma, Metastatic, Mesentery | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 0| 7| 6| 7| 1| 6| 5| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 3| 2| 4| 7| 3| 7| 3| 7| 3| 4| 7| 9| 3| 2| 1| 2| 3| 1| 3| 3| 8| 3| 8| 3| 3|
| 3| 9| 4| 3| 1| 0| 2| 0| 1| 1| 5| 7| 1| 6| 0| 9| 2| 9| 1| 0| 4| 3| 4| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0MG/M3 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 0| 2| 3| 4| 6| 9| 0| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 6| 9| 2| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Odontoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + M + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Adrenal Medulla | + + + M + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + M + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X |
Pars Distalis, Carcinoma | X |
Pars Intermedia, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + M + + + M + + + + + + + + + + + + M +|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Sarcoma, Metastatic, Mesentery | X |
Teratoma Malignant | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Polyp Stromal | |
Sarcoma, Metastatic, Mesentery | X |
Teratoma Malignant, Metastatic | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node | + + |
Iliac, Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 0| 7| 6| 7| 1| 6| 5| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 3| 2| 4| 7| 3| 7| 3| 7| 3| 4| 7| 9| 3| 2| 1| 2| 3| 1| 3| 3| 8| 3| 8| 3| 3|
| 3| 9| 4| 3| 1| 0| 2| 0| 1| 1| 5| 7| 1| 6| 0| 9| 2| 9| 1| 0| 4| 3| 4| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0MG/M3 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 0| 2| 3| 4| 6| 9| 0| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 6| 9| 2| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Histiocytic Sarcoma | X |
Pancreatic, Lymphoma Malignant | |
Pancreatic, Sarcoma, Metastatic, | |
Mesentery | X |
Renal, Lymphoma Malignant | |
Renal, Sarcoma, Metastatic, Mesentery| X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + + + + + + + + + + M + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
Sarcoma, Metastatic, Mesentery | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + M + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + M + M M + + M + + + + + + + M + +|
Hemangioma | X |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant | |
Sarcoma, Metastatic, Mesentery | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + + M M + M M M I M M + M + M M M + M M M|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
Sarcoma, Metastatic, Mesentery | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
Sarcoma, Metastatic, Mesentery | X |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + + M + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | |
Sarcoma, Metastatic, Mesentery | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Skin | + + + + + |
Sarcoma | |
Squamous Cell Papilloma | X |
_____________________________________________________________________________________________________________________|
Page 42
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 0| 7| 6| 7| 1| 6| 5| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 3| 2| 4| 7| 3| 7| 3| 7| 3| 4| 7| 9| 3| 2| 1| 2| 3| 1| 3| 3| 8| 3| 8| 3| 3|
| 3| 9| 4| 3| 1| 0| 2| 0| 1| 1| 5| 7| 1| 6| 0| 9| 2| 9| 1| 0| 4| 3| 4| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0MG/M3 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 0| 2| 3| 4| 6| 9| 0| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 6| 9| 2| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Subcutaneous Tissue, Lymphoma | |
Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + I + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + + |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant | |
Sarcoma, Metastatic, Mesentery | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Hypothalamus, Carcinoma, Metastatic | X |
Pons, Carcinoma, Metastatic | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Alveolar/Bronchiolar Carcinoma | X |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
Sarcoma, Metastatic, Mesentery | X |
Teratoma Malignant, Metastatic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant | |
Teratoma Malignant, Metastatic | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + A + + + + + + + A + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 0| 7| 6| 7| 1| 6| 5| 7| 7| 5| 7| 7| 6| 7| 7| 6| 7| 5| 7| 7|
DAY ON TEST | 3| 2| 4| 7| 3| 7| 3| 7| 3| 4| 7| 9| 3| 2| 1| 2| 3| 1| 3| 3| 8| 3| 8| 3| 3|
| 3| 9| 4| 3| 1| 0| 2| 0| 1| 1| 5| 7| 1| 6| 0| 9| 2| 9| 1| 0| 4| 3| 4| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
5.0MG/M3 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 0| 2| 3| 4| 6| 9| 0| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 6| 9| 2| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
Sarcoma, Metastatic, Mesentery | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 2| 4| 3| 3| 3| 9| 3| 2| 3| 2| | |
| 9| 0| 3| 2| 6| 5| 3| 9| 2| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
5.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + A + + + + + + + | 58 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Gallbladder | + + A + + M + + + + | 52 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + A + + + + | 53 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + M A + + M M | 40 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + A + + + + | 52 |
Leiomyosarcoma | | 1 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + A + + + + | 52 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + A + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A A + + A + + + + | 50 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Liver | + + A + + + + + + + | 58 |
Hemangiosarcoma | X | 1 |
Hepatocellular Carcinoma | | 3 |
Hepatocellular Adenoma | X | 5 |
Hepatocholangiocarcinoma | | 1 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant | | 5 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 2 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + A + + + + + + + | 57 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant | | 1 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + A + + + + + + + | 58 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + A + + A + + + + | 55 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + A + + A + + + + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 2| 4| 3| 3| 3| 9| 3| 2| 3| 2| | |
| 9| 0| 3| 2| 6| 5| 3| 9| 2| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
5.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant | X | 2 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Tooth | | 2 |
Odontoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + A + + + + + + + | 57 |
Adenoma | | 1 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + A + + + + + + + | 57 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + + + + + + | 57 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M | 52 |
__________________________________________________________________________|____________|
Pituitary Gland | + + A + + + + + + + | 57 |
Pars Distalis, Adenoma | X | 6 |
Pars Distalis, Carcinoma | | 1 |
Pars Intermedia, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M M A + + + + + + + | 50 |
__________________________________________________________________________|____________|
Ovary | + + A + + + + + + + | 58 |
Lymphoma Malignant | | 2 |
Sarcoma, Metastatic, Mesentery | | 1 |
Teratoma Malignant | | 1 |
__________________________________________________________________________|____________|
Uterus | + + A + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 2| 4| 3| 3| 3| 9| 3| 2| 3| 2| | |
| 9| 0| 3| 2| 6| 5| 3| 9| 2| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
5.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hemangiosarcoma | X | 1 |
Polyp Stromal | | 1 |
Sarcoma, Metastatic, Mesentery | | 1 |
Teratoma Malignant, Metastatic | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + A + + + + + + + | 58 |
Lymphoma Malignant | X | 3 |
__________________________________________________________________________|____________|
Lymph Node | + + | 9 |
Iliac, Lymphoma Malignant | X | 3 |
Pancreatic, Histiocytic Sarcoma | | 1 |
Pancreatic, Lymphoma Malignant | | 1 |
Pancreatic, Sarcoma, Metastatic, | | |
Mesentery | | 1 |
Renal, Lymphoma Malignant | X | 3 |
Renal, Sarcoma, Metastatic, Mesentery| | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 57 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant | X | 5 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + A + + M + + + + | 54 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + M + + + + | 51 |
Hemangioma | | 1 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant | X | 5 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M + + + M + M M | 24 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | X | 4 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Spleen | + + A + + + + + + + | 58 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant | X | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 2| 4| 3| 3| 3| 9| 3| 2| 3| 2| | |
| 9| 0| 3| 2| 6| 5| 3| 9| 2| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
5.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________|____________|
Thymus | + + M + + + + + + + | 52 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | X | 1 |
Lymphoma Malignant | | 3 |
Sarcoma, Metastatic, Mesentery | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + A + + + + + + + | 58 |
Carcinoma | | 3 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Skin | + | 11 |
Sarcoma | | 1 |
Squamous Cell Papilloma | | 1 |
Subcutaneous Tissue, Lymphoma | | |
Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant | | 1 |
Sarcoma, Metastatic, Mesentery | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
Lymphoma Malignant | | 1 |
Hypothalamus, Carcinoma, Metastatic | | 1 |
Pons, Carcinoma, Metastatic | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + A + + + + + + + | 58 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Alveolar/Bronchiolar Adenoma | X | 3 |
Alveolar/Bronchiolar Carcinoma | | 3 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| | |
DAY ON TEST | 2| 4| 3| 3| 3| 9| 3| 2| 3| 2| | |
| 9| 0| 3| 2| 6| 5| 3| 9| 2| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
5.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant | X | 4 |
Sarcoma, Metastatic, Mesentery | | 1 |
Teratoma Malignant, Metastatic | | 1 |
__________________________________________________________________________|____________|
Nose | + + A + + A + + + + | 57 |
__________________________________________________________________________|____________|
Trachea | + + A + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
__________________________________________________________________________|____________|
Eye | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 3 |
Adenoma | X | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + A + + + + + + + | 58 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant | X | 6 |
Teratoma Malignant, Metastatic | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + A + + A + + + + | 52 |
Lymphoma Malignant | | 2 |
Sarcoma, Metastatic, Mesentery | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 59 |
Histiocytic Sarcoma | X | 2 |
Lymphoma Malignant | X | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 7| 7| 2| 5| 5| 5| 6| 5| 5| 7| 6| 6| 7| 5| 4| 0| 7| 1| 6| 1| 1|
DAY ON TEST | 6| 3| 7| 8| 3| 3| 9| 5| 1| 9| 6| 5| 1| 3| 0| 0| 3| 0| 3| 0| 3| 6| 9| 6| 6|
| 0| 7| 5| 4| 8| 7| 0| 9| 2| 9| 6| 9| 0| 8| 2| 7| 8| 8| 0| 8| 8| 2| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + + + + + + + + + + A + + + + A A|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + M + + + + + + + M + + + + + + M + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Mesentery | |
Lipoma | |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + M|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Capsule, Adenoma | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M + A + + M M M + + M M + + + + M + M M + M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Thyroid Gland | + + + A + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 7| 7| 2| 5| 5| 5| 6| 5| 5| 7| 6| 6| 7| 5| 4| 0| 7| 1| 6| 1| 1|
DAY ON TEST | 6| 3| 7| 8| 3| 3| 9| 5| 1| 9| 6| 5| 1| 3| 0| 0| 3| 0| 3| 0| 3| 6| 9| 6| 6|
| 0| 7| 5| 4| 8| 7| 0| 9| 2| 9| 6| 9| 0| 8| 2| 7| 8| 8| 0| 8| 8| 2| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Penis | + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + M M + +|
__________________________________________________________________________|
Seminal Vesicle | + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Axillary, Lymphoma Malignant | |
Iliac, Lymphoma Malignant | |
Inguinal, Lymphoma Malignant | |
Renal, Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + I + + M + + + + + + + + + + + I + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + A + + + + + + + + + + + M M + M + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + M + + + + + + + + + + + + + M + M M|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M + + M M M M M M + I M M M + M M M + M M|
__________________________________________________________________________|
Spleen | + + + M + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Thymus | + + + M M + + + + + M + + + M M + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Carcinoma | X X |
Lymphoma Malignant | |
__________________________________________________________________________|
Nose | + + + A + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 7| 7| 2| 5| 5| 5| 6| 5| 5| 7| 6| 6| 7| 5| 4| 0| 7| 1| 6| 1| 1|
DAY ON TEST | 6| 3| 7| 8| 3| 3| 9| 5| 1| 9| 6| 5| 1| 3| 0| 0| 3| 0| 3| 0| 3| 6| 9| 6| 6|
| 0| 7| 5| 4| 8| 7| 0| 9| 2| 9| 6| 9| 0| 8| 2| 7| 8| 8| 0| 8| 8| 2| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|
| 1| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + I +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 3| 7| 7| 6| 7| 4| 7| 7| 7| 7| 3| 6| 7| 7| 6| 6| 6| 5| 5| 6| 7| 7| 6| 6|
DAY ON TEST | 3| 9| 3| 3| 8| 3| 7| 3| 3| 1| 3| 4| 0| 3| 3| 9| 2| 4| 9| 5| 2| 3| 3| 5| 0|
| 9| 2| 7| 9| 9| 7| 0| 8| 8| 3| 2| 1| 3| 7| 7| 4| 9| 3| 0| 9| 9| 7| 8| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 7| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + M + + + + M + + + + + + A M + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + A A + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + M A A M + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + A A + + + M A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + A A + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + A A + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + A A + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Hepatocellular Carcinoma | X X X X |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Mesentery | + |
Lipoma | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + A|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Capsule, Adenoma | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M + + + + + + + M + + + + M + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + M + + + + + + + + + + +|
Sarcoma | X |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 3| 7| 7| 6| 7| 4| 7| 7| 7| 7| 3| 6| 7| 7| 6| 6| 6| 5| 5| 6| 7| 7| 6| 6|
DAY ON TEST | 3| 9| 3| 3| 8| 3| 7| 3| 3| 1| 3| 4| 0| 3| 3| 9| 2| 4| 9| 5| 2| 3| 3| 5| 0|
| 9| 2| 7| 9| 9| 7| 0| 8| 8| 3| 2| 1| 3| 7| 7| 4| 9| 3| 0| 9| 9| 7| 8| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 7| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Penis | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + +|
Axillary, Lymphoma Malignant | X |
Iliac, Lymphoma Malignant | X |
Inguinal, Lymphoma Malignant | X |
Renal, Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + M + + I + I + + M + + M + + + I + + + + M +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + M M + + + + + + + + + M + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + M + + + + + + + I + M + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M M M + + M + M M M + M I M M M M + M M + M +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Thymus | + M M + + M + + + M + + + + + + + M I + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + I + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X X |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 3| 7| 7| 6| 7| 4| 7| 7| 7| 7| 3| 6| 7| 7| 6| 6| 6| 5| 5| 6| 7| 7| 6| 6|
DAY ON TEST | 3| 9| 3| 3| 8| 3| 7| 3| 3| 1| 3| 4| 0| 3| 3| 9| 2| 4| 9| 5| 2| 3| 3| 5| 0|
| 9| 2| 7| 9| 9| 7| 0| 8| 8| 3| 2| 1| 3| 7| 7| 4| 9| 3| 0| 9| 9| 7| 8| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/M3 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|
| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 7| 0| 1| 2| 3|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 0| 7| 7| 7| 6| 0| 0| 0| 0| | |
DAY ON TEST | 3| 0| 3| 3| 1| 4| 7| 7| 7| 7| | |
| 9| 4| 9| 9| 3| 3| 8| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/M3 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 4| 5| 6| 7| 8| 0| 1| 5| 8| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 54 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + + | 45 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + + + + | 43 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + M + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 55 |
Hemangiosarcoma | | 1 |
Hepatocellular Carcinoma | | 6 |
Hepatocellular Adenoma | | 7 |
Hepatocellular Adenoma, Multiple | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
Lipoma | | 1 |
__________________________________________________________________________|____________|
Pancreas | + M + + + + | 52 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 55 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 52 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 53 |
__________________________________________________________________________|____________|
Tooth | + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 55 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 55 |
Adenoma | | 2 |
Capsule, Adenoma | | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 55 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + M + + + + | 52 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + + + | 36 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 54 |
__________________________________________________________________________|____________|
Thyroid Gland | + M + + + + | 53 |
Follicular Cell, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 0| 7| 7| 7| 6| 0| 0| 0| 0| | |
DAY ON TEST | 3| 0| 3| 3| 1| 4| 7| 7| 7| 7| | |
| 9| 4| 9| 9| 3| 3| 8| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/M3 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 4| 5| 6| 7| 8| 0| 1| 5| 8| 9| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 54 |
Sarcoma | | 1 |
__________________________________________________________________________|____________|
Penis | | 7 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 55 |
__________________________________________________________________________|____________|
Prostate | + M + + + + | 51 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 53 |
__________________________________________________________________________|____________|
Testes | + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 54 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + | 21 |
Axillary, Lymphoma Malignant | | 1 |
Iliac, Lymphoma Malignant | | 1 |
Inguinal, Lymphoma Malignant | | 1 |
Renal, Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + I + + | 43 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M M + + + | 45 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M M M + + | 43 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M + + M | 16 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 54 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Thymus | + + + + + + | 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 54 |
__________________________________________________________________________|____________|
Skin | + | 16 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 55 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 0| 7| 7| 7| 6| 0| 0| 0| 0| | |
DAY ON TEST | 3| 0| 3| 3| 1| 4| 7| 7| 7| 7| | |
| 9| 4| 9| 9| 3| 3| 8| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/M3 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| | L |
| 4| 5| 6| 7| 8| 0| 1| 5| 8| 9| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 53 |
__________________________________________________________________________|____________|
Lung | + + + + + + | 55 |
Alveolar/Bronchiolar Adenoma | X | 7 |
Alveolar/Bronchiolar Carcinoma | | 4 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Nose | + A + + + + | 53 |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 54 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 55 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Urethra | + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + A + + + + | 52 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + | 55 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 6| 3| 6| 7| 7| 7| 7| 1| 7| 7| 7| 6| 7| 6| 0| 1| 6|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 1| 1| 9| 4| 6| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 7| 2| 3| 4|
| 8| 6| 7| 9| 9| 8| 2| 2| 4| 1| 9| 8| 9| 8| 9| 5| 9| 8| 8| 6| 9| 5| 4| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.25MGM3 | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | |
__________________________________________________________________________|
Gallbladder | + A + + + + + + A A + + + + + A + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + + + + M + + + M M A + + M + + M M A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + A + + + + + M + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + A + + + + + A + + + + + A M A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + A + + + + + A M A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + A + + A + + M + + A + + + + + A M A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Multiple | |
Hepatocellular Carcinoma | X X X X X |
Hepatocellular Carcinoma, Multiple | |
Hepatocellular Adenoma | X X |
Lymphoma Malignant | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + M +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + A +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Tooth | + + |
Odontoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + M + + + + + + + + + + + M +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + M M + M + M + M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 59
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 6| 3| 6| 7| 7| 7| 7| 1| 7| 7| 7| 6| 7| 6| 0| 1| 6|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 1| 1| 9| 4| 6| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 7| 2| 3| 4|
| 8| 6| 7| 9| 9| 8| 2| 2| 4| 1| 9| 8| 9| 8| 9| 5| 9| 8| 8| 6| 9| 5| 4| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.25MGM3 | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + M + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + +|
Axillary, Lymphoma Malignant | |
Iliac, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant | |
Renal, Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + M + + + + + I + + + + M M M M +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M M + + M + + + + + + + + + M + M + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + M + + + + + + M M +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M + + M M M + + + + M M + M M + I M M M + M M +|
Lymphoma Malignant | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Lymphoma Malignant | |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + + I M|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + +|
Hamartoma | |
Subcutaneous Tissue, Hemangioma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X X X X|
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 5| 6| 6| 3| 6| 7| 7| 7| 7| 1| 7| 7| 7| 6| 7| 6| 0| 1| 6|
DAY ON TEST | 3| 2| 3| 3| 3| 3| 1| 1| 9| 4| 6| 3| 3| 3| 3| 0| 3| 3| 3| 1| 3| 7| 2| 3| 4|
| 8| 6| 7| 9| 9| 8| 2| 2| 4| 1| 9| 8| 9| 8| 9| 5| 9| 8| 8| 6| 9| 5| 4| 5| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1.25MGM3 | 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
| 1| 2| 3| 4| 5| 6| 8| 9| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 6| 7| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hepatocellular Carcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + A + + + + + + + + +|
Transitional Epithelium, Papilloma | |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 6| 1| 5| 6| 6| 6| 7| 7| 2| 7| 2| 4| 4| 6| 4| 7| 7| 2| 7| 4| 7| 6| 6| 7|
DAY ON TEST | 3| 4| 5| 9| 8| 0| 1| 3| 3| 9| 2| 2| 9| 4| 1| 8| 3| 3| 9| 3| 7| 3| 4| 3| 0|
| 8| 4| 7| 3| 3| 4| 0| 9| 8| 0| 6| 6| 3| 5| 2| 0| 8| 9| 8| 9| 1| 9| 9| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 0| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X |
__________________________________________________________________________|
Gallbladder | + + A + + + A + + + + + + A + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + A + + + + M M + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + M + + + A + + + + + + + + A + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A + + + + + + A + A + + + + A + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + M + + + A + + + + + + A + A + + + + A + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + M + + + A + + + + + + A + A + + + M A + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma, Multiple | |
Hepatocellular Carcinoma | X X X |
Hepatocellular Carcinoma, Multiple | X X X|
Hepatocellular Adenoma | X X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + + |
Odontoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + M M M M M M + + + + M + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + I + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + + |
__________________________________________________________________________|
Preputial Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 6| 1| 5| 6| 6| 6| 7| 7| 2| 7| 2| 4| 4| 6| 4| 7| 7| 2| 7| 4| 7| 6| 6| 7|
DAY ON TEST | 3| 4| 5| 9| 8| 0| 1| 3| 3| 9| 2| 2| 9| 4| 1| 8| 3| 3| 9| 3| 7| 3| 4| 3| 0|
| 8| 4| 7| 3| 3| 4| 0| 9| 8| 0| 6| 6| 3| 5| 2| 0| 8| 9| 8| 9| 1| 9| 9| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 0| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + M + + + M + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + I + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Axillary, Lymphoma Malignant | X |
Iliac, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant | X |
Renal, Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + M + + + + + + + + + M + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + + + + + + + + + M M|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | M M + + + + + + M M + + + M + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M + M M M M M M + M M M I M M + M M M + + M M|
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Thymus | + + + + M + I + I + + + + + + + + + + M + M + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + |
Hamartoma | |
Subcutaneous Tissue, Hemangioma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + M + M + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
Alveolar/Bronchiolar Carcinoma | X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 6| 1| 5| 6| 6| 6| 7| 7| 2| 7| 2| 4| 4| 6| 4| 7| 7| 2| 7| 4| 7| 6| 6| 7|
DAY ON TEST | 3| 4| 5| 9| 8| 0| 1| 3| 3| 9| 2| 2| 9| 4| 1| 8| 3| 3| 9| 3| 7| 3| 4| 3| 0|
| 8| 4| 7| 3| 3| 4| 0| 9| 8| 0| 6| 6| 3| 5| 2| 0| 8| 9| 8| 9| 1| 9| 9| 7| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1.25MGM3 | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|
| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6| 0| 2| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Urethra | + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Papilloma | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 1| 9| 7| 3| 3| 2| 0| 4| | |
| 7| 9| 7| 2| 9| 8| 8| 6| 8| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.25MGM3 | 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Squamous Cell Carcinoma | | 1 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + A + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + A A | 54 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + A A | 44 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + A A | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + A A | 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + A A | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + A A | 43 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hemangiosarcoma, Multiple | X | 1 |
Hepatocellular Carcinoma | X X X | 11 |
Hepatocellular Carcinoma, Multiple | | 3 |
Hepatocellular Adenoma | X | 5 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + M | 58 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + A A | 57 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + A A | 57 |
__________________________________________________________________________|____________|
Tooth | | 5 |
Odontoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + M | 57 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + | 42 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + | 55 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Bilateral, Follicular Cell, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 65
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 1| 9| 7| 3| 3| 2| 0| 4| | |
| 7| 9| 7| 2| 9| 8| 8| 6| 8| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.25MGM3 | 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Penis | + + + | 8 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + M | 55 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + A | 59 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + | 13 |
Axillary, Lymphoma Malignant | | 1 |
Iliac, Lymphoma Malignant | | 1 |
Pancreatic, Lymphoma Malignant | | 1 |
Renal, Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + M + M + + + + + | 50 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + | 51 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + M + + + + M | 48 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M M M M + M M M | 19 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Thymus | + + + I + + + M + M | 49 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin | + + + + | 18 |
Hamartoma | X | 1 |
Subcutaneous Tissue, Hemangioma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 66
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 6| 6| 7| 7| 7| 5| 4| | |
DAY ON TEST | 3| 3| 1| 9| 7| 3| 3| 2| 0| 4| | |
| 7| 9| 7| 2| 9| 8| 8| 6| 8| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
1.25MGM3 | 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | X | 5 |
Alveolar/Bronchiolar Carcinoma | X X | 8 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + A + + + + + | 59 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Urethra | | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + A A | 56 |
Transitional Epithelium, Papilloma | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 67
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 6| 7| 3| 7| 6| 7| 7| 7| 4| 7| 5| 6| 7| 5|
DAY ON TEST | 0| 1| 3| 3| 3| 9| 3| 3| 3| 6| 3| 4| 3| 5| 3| 6| 3| 3| 3| 8| 3| 8| 8| 3| 3|
| 3| 6| 7| 7| 9| 6| 9| 8| 8| 3| 8| 8| 9| 6| 7| 5| 8| 0| 9| 9| 8| 0| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6| 7| 8| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + A + + + + + + + + + + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + M + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X X X|
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X|
Hepatocellular Adenoma, Multiple | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + + |
Odontoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + M + + + +|
Capsule, Adenoma | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + M + + M + + + + + + + + + + + + M + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + |
Lipoma | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + + |
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 6| 7| 3| 7| 6| 7| 7| 7| 4| 7| 5| 6| 7| 5|
DAY ON TEST | 0| 1| 3| 3| 3| 9| 3| 3| 3| 6| 3| 4| 3| 5| 3| 6| 3| 3| 3| 8| 3| 8| 8| 3| 3|
| 3| 6| 7| 7| 9| 6| 9| 8| 8| 3| 8| 8| 9| 6| 7| 5| 8| 0| 9| 9| 8| 0| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6| 7| 8| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Iliac, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mesenteric | M M + + M M + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + M M + M M + M M + M I M I + M + M + M M M M M|
Hemangiosarcoma, Metastatic | |
Lymphoma Malignant | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
__________________________________________________________________________|
Thymus | + + + + M + + I + + M + + + + I + + + + M + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + I + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | X X X X |
Hepatocellular Carcinoma, Metastatic | X X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 6| 5| 7| 7| 7| 6| 5| 7| 7| 4| 7| 6| 7| 3| 7| 6| 7| 7| 7| 4| 7| 5| 6| 7| 5|
DAY ON TEST | 0| 1| 3| 3| 3| 9| 3| 3| 3| 6| 3| 4| 3| 5| 3| 6| 3| 3| 3| 8| 3| 8| 8| 3| 3|
| 3| 6| 7| 7| 9| 6| 9| 8| 8| 3| 8| 8| 9| 6| 7| 5| 8| 0| 9| 9| 8| 0| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/M3 | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6| 7| 8| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ureter | + + |
__________________________________________________________________________|
Urethra | + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 1| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 5| 3| 3| 4| 3| 0| 3| 7| 7| 3| 3| 3| 3| 3| 7| 0| 3| 5| 3| 3| 4| 1| 0| 3| 6|
| 5| 7| 7| 0| 9| 5| 7| 6| 7| 7| 8| 7| 7| 7| 6| 4| 7| 2| 8| 8| 9| 2| 9| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/M3 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 0| 4| 5| 7| 9| 0| 2| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | A + + A + A + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + A M + +|
__________________________________________________________________________|
Intestine Large, Rectum | M M + A + + + + + + + + I M + + + + + + + A M + M|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + M + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + A + A + + + + + + + + + + + + + + + A A + +|
Adenoma | X |
__________________________________________________________________________|
Intestine Small, Jejunum | A + + A + A + + + + + + + + + + + + + + + A A + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + A + A + + + M + + + + + + + + + + + A A + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X X X |
Hepatocellular Adenoma, Multiple | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | + |
Odontoma | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Adenoma | X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Parathyroid Gland | M + M M + + + M + + + + + + + + + M + + + M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Lipoma | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + +|
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 1| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 5| 3| 3| 4| 3| 0| 3| 7| 7| 3| 3| 3| 3| 3| 7| 0| 3| 5| 3| 3| 4| 1| 0| 3| 6|
| 5| 7| 7| 0| 9| 5| 7| 6| 7| 7| 8| 7| 7| 7| 6| 4| 7| 2| 8| 8| 9| 2| 9| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/M3 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 0| 4| 5| 7| 9| 0| 2| 6| 7|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + M + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + +|
Iliac, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Bronchial | I + + + M + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + M + + + + M + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M M M M + M + M + M M M + + M + M M M M + M|
Hemangiosarcoma, Metastatic | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
__________________________________________________________________________|
Thymus | M + + I + + + + + + + + + + + + + M + + M M + M +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Carcinoma | X X X |
Hepatocellular Carcinoma, Metastatic | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 72
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 1| 7| 7| 5| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6|
DAY ON TEST | 5| 3| 3| 4| 3| 0| 3| 7| 7| 3| 3| 3| 3| 3| 7| 0| 3| 5| 3| 3| 4| 1| 0| 3| 6|
| 5| 7| 7| 0| 9| 5| 7| 6| 7| 7| 8| 7| 7| 7| 6| 4| 7| 2| 8| 8| 9| 2| 9| 8| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2.5MG/M3 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 5| 6| 7| 8| 0| 4| 5| 7| 9| 0| 2| 6| 7|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Ureter | |
__________________________________________________________________________|
Urethra | + + |
__________________________________________________________________________|
Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 73
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 4| 7| 7| 7| 4| | |
DAY ON TEST | 3| 6| 6| 2| 3| 8| 3| 3| 1| 8| | |
| 7| 5| 0| 9| 7| 3| 7| 8| 8| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
2.5MG/M3 | 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 8| 9| 0| 1| 2| 4| 5| 6| 8| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + A | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + I + + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A | 53 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A | 52 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Hepatocellular Carcinoma | | 8 |
Hepatocellular Carcinoma, Multiple | | 2 |
Hepatocellular Adenoma | | 11 |
Hepatocellular Adenoma, Multiple | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Tooth | + | 4 |
Odontoma | | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Capsule, Adenoma | | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + + + | 57 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 74
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 4| 7| 7| 7| 4| | |
DAY ON TEST | 3| 6| 6| 2| 3| 8| 3| 3| 1| 8| | |
| 7| 5| 0| 9| 7| 3| 7| 8| 8| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
2.5MG/M3 | 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 8| 9| 0| 1| 2| 4| 5| 6| 8| 0| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
Lipoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Penis | + | 6 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Interstitial Cell, Adenoma | | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + | 17 |
Iliac, Lymphoma Malignant | | 1 |
Pancreatic, Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + I + + | 56 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + | 57 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + I + + + + | 52 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + M M I M M M | 19 |
Hemangiosarcoma, Metastatic | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hemangiosarcoma | | 2 |
__________________________________________________________________________|____________|
Thymus | M + + + + + + + M + | 47 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Skin | + + + + + | 22 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 75
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 4| 7| 7| 7| 4| | |
DAY ON TEST | 3| 6| 6| 2| 3| 8| 3| 3| 1| 8| | |
| 7| 5| 0| 9| 7| 3| 7| 8| 8| 3| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
2.5MG/M3 | 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 8| 9| 0| 1| 2| 4| 5| 6| 8| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | | 6 |
Alveolar/Bronchiolar Carcinoma | X X | 9 |
Hepatocellular Carcinoma, Metastatic | | 3 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
Adenoma | X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Ureter | | 2 |
__________________________________________________________________________|____________|
Urethra | | 5 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 76
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 1| 7| 7| 7| 5| 7| 7| 2| 7| 7| 5| 1| 6| 7| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 4| 9| 3| 3| 3| 2| 3| 3| 4| 3| 3| 8| 3| 9| 3| 3| 3| 3| 1| 3| 4| 0|
| 9| 8| 6| 3| 4| 9| 9| 8| 7| 7| 9| 1| 9| 7| 0| 7| 8| 9| 9| 7| 8| 6| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 8| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + M + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Large, Rectum | + M M + A + M M + + M + M + + + + + M + + + M + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + A M|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + + + A +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Hemangiosarcoma | |
Hepatocellular Carcinoma | X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X |
Hepatocholangiocarcinoma | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Tooth | |
Odontoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + M + + + M M + + + M + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 1| 7| 7| 7| 5| 7| 7| 2| 7| 7| 5| 1| 6| 7| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 4| 9| 3| 3| 3| 2| 3| 3| 4| 3| 3| 8| 3| 9| 3| 3| 3| 3| 1| 3| 4| 0|
| 9| 8| 6| 3| 4| 9| 9| 8| 7| 7| 9| 1| 9| 7| 0| 7| 8| 9| 9| 7| 8| 6| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 8| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + I + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + |
Axillary, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Axillary, Lymphoma Malignant | |
Iliac, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant | |
Renal, Lymphoma Malignant | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + M + + + + + + M + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + M + + + + + + + + + + + + + + + M|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mediastinal | I + + + M M M M + M M M M I M + + M M M M + M + M|
Lymphoma Malignant | X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hemangiosarcoma | |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 1| 7| 7| 7| 5| 7| 7| 2| 7| 7| 5| 1| 6| 7| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 4| 9| 3| 3| 3| 2| 3| 3| 4| 3| 3| 8| 3| 9| 3| 3| 3| 3| 1| 3| 4| 0|
| 9| 8| 6| 3| 4| 9| 9| 8| 7| 7| 9| 1| 9| 7| 0| 7| 8| 9| 9| 7| 8| 6| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 8| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + I + + + M + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X X|
Alveolar/Bronchiolar Carcinoma | X X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Hepatocellular Carcinoma, Metastatic | X X |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urethra | + + + + + +|
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 1| 7| 7| 7| 5| 7| 7| 2| 7| 7| 5| 1| 6| 7| 7| 7| 5| 6| 7| 6| 7|
DAY ON TEST | 3| 3| 3| 4| 9| 3| 3| 3| 2| 3| 3| 4| 3| 3| 8| 3| 9| 3| 3| 3| 3| 1| 3| 4| 0|
| 9| 8| 6| 3| 4| 9| 9| 8| 7| 7| 9| 1| 9| 7| 0| 7| 8| 9| 9| 7| 8| 6| 7| 1| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1|
| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 4| 5| 6| 8| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Histiocytic Sarcoma | |
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 4| 4| 7| 7| 6| 2| 6| 4| 6| 7| 7| 5| 7| 7| 5| 7| 6| 5| 2| 6| 7|
DAY ON TEST | 1| 9| 8| 3| 5| 2| 2| 0| 9| 7| 5| 2| 0| 3| 3| 7| 2| 3| 0| 3| 7| 5| 2| 5| 3|
| 3| 9| 9| 7| 9| 8| 6| 4| 7| 1| 9| 2| 1| 8| 7| 4| 6| 8| 1| 7| 0| 9| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 3| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 6| 7| 9| 0| 2| 3| 4| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + M + + A A + + + + + + A + + A + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + A A A + + + + + + A + + + + A +|
Lymphoma Malignant | |
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + + + + M A A A + + + + + + A + + + + A M|
__________________________________________________________________________|
Intestine Large, Cecum | + M + + A + + + + A A A + + + + + + A + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + A + + A + + + + A A A + + + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + A + + + + A A A + + + + + + A + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + A + + + + A A A + + + + + + A + + M + A +|
Lymphoma Malignant | X|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Hemangiosarcoma | X X |
Hepatocellular Carcinoma | X X X X X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X |
Hepatocholangiocarcinoma | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + A + + + + + + + + + + + A +|
Squamous Cell Papilloma | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + A + + + + + + + + + + + A +|
__________________________________________________________________________|
Tooth | |
Odontoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + I + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 4| 4| 7| 7| 6| 2| 6| 4| 6| 7| 7| 5| 7| 7| 5| 7| 6| 5| 2| 6| 7|
DAY ON TEST | 1| 9| 8| 3| 5| 2| 2| 0| 9| 7| 5| 2| 0| 3| 3| 7| 2| 3| 0| 3| 7| 5| 2| 5| 3|
| 3| 9| 9| 7| 9| 8| 6| 4| 7| 1| 9| 2| 1| 8| 7| 4| 6| 8| 1| 7| 0| 9| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 3| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 6| 7| 9| 0| 2| 3| 4| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Follicular Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Penis | + + + + + + + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + M + + + + + + + + + + + + M + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + +|
Axillary, Alveolar/Bronchiolar | |
Carcinoma, Metastatic, Lung | |
Axillary, Lymphoma Malignant | X|
Iliac, Lymphoma Malignant | X|
Pancreatic, Lymphoma Malignant | X|
Renal, Lymphoma Malignant | X|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M + + + + + A + + + + + + + + + + + + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant | X|
__________________________________________________________________________|
Lymph Node, Mandibular | M + + + + M + + + + + A + + + + + + + M + + + + +|
Lymphoma Malignant | X|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + M M + + + + + + M + + + M + +|
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Lymphoma Malignant | X|
__________________________________________________________________________|
Lymph Node, Mediastinal | I M + + M + + + M M M + M M M + M M M I + M M + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Hemangiosarcoma | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X|
__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + I + M + M M + M M + +|
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 4| 4| 7| 7| 6| 2| 6| 4| 6| 7| 7| 5| 7| 7| 5| 7| 6| 5| 2| 6| 7|
DAY ON TEST | 1| 9| 8| 3| 5| 2| 2| 0| 9| 7| 5| 2| 0| 3| 3| 7| 2| 3| 0| 3| 7| 5| 2| 5| 3|
| 3| 9| 9| 7| 9| 8| 6| 4| 7| 1| 9| 2| 1| 8| 7| 4| 6| 8| 1| 7| 0| 9| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 3| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 6| 7| 9| 0| 2| 3| 4| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Alveolar/Bronchiolar Carcinoma, | |
Metastatic, Lung | |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X|
Alveolar/Bronchiolar Carcinoma | X |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | X |
Hepatocellular Carcinoma, Metastatic | X X |
Hepatocholangiocarcinoma, Metastatic,| |
Liver | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | |
__________________________________________________________________________|
Nose | + + + + A + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Adenoma | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + A + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________________________________________|
Ureter | + |
__________________________________________________________________________|
Urethra | + + + + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + A + + + + + + + + + + + A +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
_____________________________________________________________________________________________________________________
| 7| 4| 4| 7| 4| 4| 7| 7| 6| 2| 6| 4| 6| 7| 7| 5| 7| 7| 5| 7| 6| 5| 2| 6| 7|
DAY ON TEST | 1| 9| 8| 3| 5| 2| 2| 0| 9| 7| 5| 2| 0| 3| 3| 7| 2| 3| 0| 3| 7| 5| 2| 5| 3|
| 3| 9| 9| 7| 9| 8| 6| 4| 7| 1| 9| 2| 1| 8| 7| 4| 6| 8| 1| 7| 0| 9| 4| 9| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
5.0MG/M3 | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|
| 3| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 3| 6| 7| 9| 0| 2| 3| 4| 6| 7| 8|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS - cont | |
| |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X|
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 9| 3| 3| 9| 1| 3| 3| 1| 3| 1| | |
| 7| 7| 9| 8| 6| 7| 9| 4| 5| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
5.0MG/M3 | 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 53 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + + M + + + | 41 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | M + + + + + + + + + | 52 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 50 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + M + + | 49 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Hemangiosarcoma | | 2 |
Hepatocellular Carcinoma | X X | 13 |
Hepatocellular Carcinoma, Multiple | | 2 |
Hepatocellular Adenoma | | 8 |
Hepatocholangiocarcinoma | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Squamous Cell Papilloma | | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Tooth | + | 1 |
Odontoma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Adenoma | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 85
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 9| 3| 3| 9| 1| 3| 3| 1| 3| 1| | |
| 7| 7| 9| 8| 6| 7| 9| 4| 5| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
5.0MG/M3 | 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + M | 51 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + M + | 57 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Adenoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Penis | + + | 10 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Lymph Node | + + | 12 |
Axillary, Alveolar/Bronchiolar | | |
Carcinoma, Metastatic, Lung | X | 1 |
Axillary, Lymphoma Malignant | | 1 |
Iliac, Lymphoma Malignant | | 2 |
Pancreatic, Lymphoma Malignant | | 1 |
Renal, Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + I | 55 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M | 52 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 54 |
Hepatocholangiocarcinoma, Metastatic,| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 86
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 9| 3| 3| 9| 1| 3| 3| 1| 3| 1| | |
| 7| 7| 9| 8| 6| 7| 9| 4| 5| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
5.0MG/M3 | 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Liver | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M I I M M M + M + M | 20 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Hemangioma | X | 1 |
Hemangiosarcoma | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Thymus | I + + + + + + + M + | 51 |
Alveolar/Bronchiolar Carcinoma, | | |
Metastatic, Lung | X | 1 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Skin | + + + + | 22 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + I | 59 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Alveolar/Bronchiolar Adenoma | | 9 |
Alveolar/Bronchiolar Carcinoma | X | 4 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | | 1 |
Hepatocellular Carcinoma, Metastatic | | 4 |
Hepatocholangiocarcinoma, Metastatic,| | |
Liver | | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 87
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 9| 3| 3| 9| 1| 3| 3| 1| 3| 1| | |
| 7| 7| 9| 8| 6| 7| 9| 4| 5| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
5.0MG/M3 | 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 9| 0| 2| 3| 4| 5| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Trachea | + M + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + + | 3 |
Adenoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Ureter | + | 3 |
__________________________________________________________________________|____________|
Urethra | + | 11 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 57 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 60 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 88
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