TDMS Study 05123-06 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
NICKEL OXIDE
NTP Experiment-Test: 05123-06 Report: PEIRPT03
Study Type: CHRONIC Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 1313-99-1
Lock Date: 04/19/94
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/M3 0 MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 20 60 20 60 20
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund Sacrifice 12 3 15 3 6 3
Natural Death 6 1 5 3 10 1
Accidently Killed 1 1
Survivors
Moribund Sacrifice 2
Terminal Sacrifice 40 38 42
Natural Death 1
Terminal Sacrifice 6 4 6
Other 1
Animals Examined Microscopically 60 14 60 16 59 14
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (57) (8) (56) (8) (54) (8)
Inflammation, Suppurative 1 (2%)
Intestine Large, Cecum (57) (8) (57) (8) (54) (8)
Hyperplasia, Lymphoid 1 (2%) 4 (7%)
Intestine Small, Duodenum (57) (8) (56) (9) (53) (8)
Hyperplasia, Lymphoid 2 (4%)
Inflammation, Suppurative 1 (2%)
Intestine Small, Ileum (55) (8) (54) (8) (53) (8)
Hyperplasia, Lymphoid 2 (4%)
Liver (60) (9) (60) (11) (59) (9)
Abscess 1 (2%)
Basophilic Focus 1 (2%) 1 (2%) 1 (2%)
Clear Cell Focus 2 (3%) 1 (2%)
Eosinophilic Focus 2 (3%) 2 (3%)
Infiltration Cellular, Lymphocyte 1 (11%)
Inflammation, Chronic 1 (2%) 1 (9%)
Inflammation, Chronic, Focal 1 (2%) 3 (5%) 3 (5%)
Mixed Cell Focus 1 (2%)
Hepatocyte, Fatty Change 1 (2%)
Hepatocyte, Hyperplasia 1 (2%)
Hepatocyte, Necrosis 1 (2%) 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Sinusoid, Amyloid Deposition 1 (2%)
Mesentery (2) (2) (1)
Artery, Inflammation, Chronic 2 (100%)
Pancreas (60) (9) (60) (11) (58) (9)
Atrophy 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/M3 0 MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Congestion 1 (2%)
Cyst 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Stomach, Forestomach (60) (9) (59) (9) (58) (9)
Hyperkeratosis 1 (2%) 8 (14%) 2 (3%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Stomach, Glandular (59) (9) (59) (9) (58) (9)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Tooth (2) (1) (1)
Developmental Malformation 1 (50%) 1 (100%)
Inflammation 1 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (9) (60) (11) (59) (9)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%)
Arteriole, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (9) (60) (11) (59) (9)
Hyperplasia 1 (2%) 2 (3%) 1 (2%)
Infiltration Cellular 1 (11%)
Vacuolization Cytoplasmic 1 (2%)
Spindle Cell, Hyperplasia 4 (7%) 1 (2%) 1 (9%)
Adrenal Medulla (60) (7) (59) (11) (59) (9)
Degeneration 1 (2%)
Hyperplasia 1 (2%)
Spindle Cell, Hyperplasia 1 (2%) 2 (3%)
Islets, Pancreatic (59) (9) (59) (11) (58) (9)
Hyperplasia 1 (2%)
Pituitary Gland (59) (9) (60) (11) (57) (9)
Pars Distalis, Angiectasis 7 (12%) 10 (17%) 11 (19%) 1 (11%)
Pars Distalis, Hyperplasia 10 (17%) 9 (15%) 4 (7%)
Thyroid Gland (59) (8) (60) (11) (59) (9)
Hyperplasia, Cystic 26 (44%) 25 (42%) 1 (9%) 32 (54%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Suppurative 2 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/M3 0 MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (54) (8) (56) (11) (53) (9)
Ectasia 1 (2%) 2 (4%)
Inflammation, Chronic 2 (4%)
Pigmentation 5 (9%) 4 (7%) 5 (9%)
Ovary (57) (9) (60) (11) (57) (8)
Abscess 2 (4%)
Congestion 1 (2%)
Cyst 8 (14%) 14 (23%) 1 (9%) 9 (16%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Rete Ovarii, Thrombosis 1 (2%)
Uterus (60) (9) (60) (11) (58) (9)
Cyst 1 (2%)
Dilatation 1 (9%)
Inflammation, Suppurative 1 (2%)
Bilateral, Dilatation 1 (2%)
Bilateral, Endometrium, Hyperplasia 1 (11%)
Endometrium, Hyperplasia 3 (33%) 5 (45%) 5 (56%)
Endometrium, Hyperplasia, Cystic 24 (40%) 33 (55%) 1 (9%) 28 (48%) 2 (22%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (9) (59) (11) (58) (9)
Myelofibrosis 3 (5%) 2 (3%)
Necrosis 1 (2%) 1 (2%)
Myeloid Cell, Hyperplasia 5 (8%) 3 (5%) 1 (9%) 3 (5%)
Lymph Node (15) (8) (1) (9) (1)
Iliac, Hyperplasia, Lymphoid 3 (20%) 2 (25%) 1 (11%)
Iliac, Pigmentation 1 (13%)
Pancreatic, Hyperplasia, Lymphoid 1 (100%)
Renal, Hyperplasia, Lymphoid 4 (27%) 1 (13%) 1 (11%)
Lymph Node, Bronchial (53) (9) (58) (14) (56) (13)
Congestion 2 (3%) 1 (2%)
Hyperplasia 1 (7%)
Hyperplasia, Lymphoid 14 (26%) 36 (62%) 4 (29%) 38 (68%) 6 (46%)
Pigmentation 54 (93%) 9 (64%) 53 (95%) 13 (100%)
Lymph Node, Mandibular (58) (8) (58) (11) (55) (9)
Congestion 1 (2%) 1 (11%)
Hyperplasia, Lymphoid 16 (28%) 15 (26%) 6 (55%) 16 (29%) 2 (22%)
Hyperplasia, Macrophage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/M3 0 MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Inflammation, Suppurative 1 (2%)
Lymph Node, Mesenteric (53) (6) (58) (10) (51) (8)
Congestion 4 (7%) 1 (13%)
Ectasia 1 (2%)
Hyperplasia, Lymphoid 8 (15%) 3 (5%) 8 (16%)
Inflammation 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%)
Lymph Node, Mediastinal (35) (2) (27) (7) (31) (5)
Hyperplasia 1 (14%)
Hyperplasia, Lymphoid 1 (3%) 3 (11%) 1 (14%) 3 (10%)
Pigmentation 2 (7%) 1 (3%)
Spleen (60) (9) (60) (12) (59) (9)
Hematopoietic Cell Proliferation 8 (13%) 4 (7%) 2 (17%) 7 (12%) 1 (11%)
Hyperplasia, Lymphoid 12 (20%) 1 (11%) 16 (27%) 4 (33%) 21 (36%) 2 (22%)
Hyperplasia, Macrophage 1 (2%)
Thymus (56) (8) (55) (11) (57) (8)
Atrophy 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (9) (60) (11) (59) (9)
Hyperplasia, Glandular 6 (10%) 3 (5%) 1 (9%) 8 (14%)
Skin (4) (6) (2) (5) (1)
Alopecia 1 (17%) 1 (20%)
Inflammation, Chronic Active 1 (25%)
Inflammation, Suppurative 1 (100%)
Pinna, Cyst Epithelial Inclusion 1 (17%)
Subcutaneous Tissue, Edema 1 (25%) 1 (17%)
Subcutaneous Tissue, Inflammation,
Suppurative 1 (20%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (9) (59) (11) (59) (9)
Fracture 1 (2%)
Hyperostosis 17 (28%) 25 (42%) 25 (42%) 1 (11%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/M3 0 MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (9) (60) (11) (59) (9)
Hypothalamus, Compression 2 (3%) 6 (10%)
Pons, Compression 1 (2%)
Spinal Cord (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (58) (9) (57) (11) (58) (9)
Inflammation, Suppurative 1 (2%) 1 (2%)
Lung (60) (14) (60) (16) (59) (14)
Fibrosis 1 (2%)
Hemorrhage 2 (3%)
Inflammation, Chronic 7 (12%) 40 (67%) 6 (38%) 50 (85%) 11 (79%)
Inflammation, Chronic Active 1 (2%)
Pigmentation, Hemosiderin 2 (3%)
Alveolar Epithelium, Hyperplasia 34 (57%) 1 (6%) 37 (63%) 5 (36%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%)
Alveolus, Hemorrhage 1 (2%)
Alveolus, Hyperplasia, Macrophage 1 (2%) 1 (2%) 1 (6%)
Alveolus, Pigmentation 59 (98%) 13 (81%) 58 (98%) 13 (93%)
Alveolus, Proteinosis 8 (13%) 17 (29%)
Nose (59) (13) (60) (15) (59) (13)
Inflammation, Suppurative 1 (2%)
Capillary, Thrombosis 1 (2%)
Olfactory Epithelium, Degeneration 15 (25%) 4 (31%) 9 (15%) 1 (7%) 2 (3%)
Respiratory Epithelium, Degeneration 19 (32%) 2 (15%) 14 (23%) 2 (13%) 10 (17%) 3 (23%)
Respiratory Epithelium, Hyperplasia 1 (2%) 1 (2%)
Respiratory Epithelium, Inflammation, Chronic 1 (2%)
Respiratory Epithelium, Inflammation,
Suppurative 17 (29%) 16 (27%) 2 (13%) 17 (29%) 1 (8%)
Respiratory Epithelium, Metaplasia, Squamous 10 (17%) 9 (15%) 13 (22%) 1 (8%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2) (1) (1)
External Ear, Hyperkeratosis 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/M3 0 MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (14) (60) (16) (59) (14)
Hydronephrosis 1 (2%)
Infiltration Cellular, Lymphocyte 1 (7%) 2 (13%) 2 (3%) 1 (7%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (7%)
Metaplasia, Osseous 1 (2%)
Nephropathy 2 (3%) 3 (5%) 3 (5%)
Glomerulus, Thrombosis 1 (2%)
Medulla, Cyst 1 (2%)
Pelvis, Infiltration Cellular, Lymphocyte 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Urinary Bladder (60) (8) (58) (9) (56) (9)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 5.0MG/M3 5.0MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 20
Scheduled Sacrifice 10
Early Deaths
Moribund Sacrifice 12 4
Natural Death 9 1
Survivors
Terminal Sacrifice 38
Terminal Sacrifice 5
Other 1
Animals Examined Microscopically 59 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (52) (9)
Hyperplasia, Lymphoid 1 (2%)
Liver (58) (10)
Basophilic Focus 1 (2%)
Clear Cell Focus 1 (2%)
Hepatocyte, Necrosis 3 (5%)
Mesentery (2) (1)
Inflammation, Chronic Active 1 (100%)
Fat, Necrosis 1 (100%)
Stomach, Forestomach (55) (10)
Hyperkeratosis 1 (2%)
Hyperplasia, Squamous 1 (2%)
Tooth (2)
Developmental Malformation 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (59) (10)
Venule, Inflammation, Chronic Active 1 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (57) (10)
Hyperplasia 1 (2%)
Spindle Cell, Hyperplasia 1 (2%)
Pituitary Gland (57) (10)
Pars Distalis, Angiectasis 7 (12%)
Pars Distalis, Hyperplasia 8 (14%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 5.0MG/M3 5.0MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Necrosis 1 (2%)
Thyroid Gland (59) (10)
Hyperplasia, Cystic 25 (42%) 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (10)
Ectasia 3 (6%)
Inflammation, Chronic 1 (10%)
Inflammation, Chronic Active 1 (2%)
Pigmentation 12 (24%)
Ovary (58) (10)
Angiectasis 2 (3%)
Cyst 7 (12%)
Uterus (58) (11)
Inflammation, Suppurative 1 (2%) 1 (9%)
Endometrium, Hyperplasia 5 (45%)
Endometrium, Hyperplasia, Cystic 26 (45%) 3 (27%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (58) (10)
Myelofibrosis 2 (3%)
Myeloid Cell, Hyperplasia 1 (10%)
Lymph Node (9)
Iliac, Hyperplasia, Lymphoid 1 (11%)
Iliac, Hyperplasia, Macrophage 1 (11%)
Pancreatic, Hyperplasia, Lymphoid 1 (11%)
Renal, Hyperplasia, Lymphoid 2 (22%)
Renal, Inflammation, Chronic Active 1 (11%)
Lymph Node, Bronchial (57) (15)
Congestion 2 (4%)
Hyperplasia, Lymphoid 41 (72%) 7 (47%)
Pigmentation 55 (96%) 15 (100%)
Lymph Node, Mandibular (54) (9)
Hyperplasia, Lymphoid 13 (24%) 1 (11%)
Lymph Node, Mesenteric (51) (9)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Lymphoid 13 (25%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 5.0MG/M3 5.0MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Mediastinal (24) (9)
Hyperplasia, Lymphoid 2 (8%)
Pigmentation 4 (17%) 1 (11%)
Spleen (58) (10)
Congestion 2 (3%)
Hematopoietic Cell Proliferation 5 (9%)
Hyperplasia, Lymphoid 17 (29%)
Hyperplasia, Macrophage 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (58) (10)
Hyperplasia, Glandular 8 (14%)
Skin (11) (2)
Alopecia 1 (9%)
Edema 1 (9%)
Hemorrhage 2 (18%)
Inflammation, Chronic 1 (9%)
Epidermis, Inflammation, Suppurative 1 (50%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (50%)
Subcutaneous Tissue, Necrosis 1 (50%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (58) (10)
Hyperostosis 23 (40%) 1 (10%)
Pelvis, Fracture 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (59) (10)
Hypothalamus, Compression 4 (7%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (59) (15)
Fibrosis 3 (5%)
Inflammation, Chronic 48 (81%) 12 (80%)
Metaplasia, Squamous 1 (2%)
Alveolar Epithelium, Hyperplasia 37 (63%) 6 (40%)
Alveolus, Pigmentation 59 (100%) 15 (100%)
Alveolus, Proteinosis 27 (46%) 5 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 5.0MG/M3 5.0MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nose (57) (15)
Olfactory Epithelium, Degeneration 6 (11%) 1 (7%)
Respiratory Epithelium, Degeneration 16 (28%) 4 (27%)
Respiratory Epithelium, Inflammation,
Suppurative 21 (37%)
Respiratory Epithelium, Metaplasia, Squamous 15 (26%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (1)
External Ear, Hemorrhage 1 (100%)
Eye (2)
Cornea, Inflammation 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (58) (15)
Infiltration Cellular, Lymphocyte 2 (13%)
Necrosis 1 (2%)
Nephropathy 1 (2%) 1 (7%)
Cortex, Cyst 1 (2%)
Urethra (1)
Concretion 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/M3 O MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 20 60 20 60 20
Scheduled Sacrifice 10 10 10
Early Deaths
Moribund Sacrifice 22 1 20 6 23 3
Natural Death 14 1 17 1 8 3
Accidently Killed 4 6
Survivors
Terminal Sacrifice 19 23 29
Terminal Sacrifice 2 3 4
Other 1
Animals Examined Microscopically 55 12 60 17 60 16
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (45) (7) (49) (10) (53) (9)
Necrosis 1 (2%)
Intestine Large, Cecum (47) (7) (49) (12) (56) (9)
Inflammation, Chronic 1 (2%)
Intestine Small, Ileum (49) (7) (43) (11) (52) (8)
Inflammation, Suppurative 1 (2%)
Ulcer 1 (2%)
Liver (55) (8) (60) (12) (60) (13)
Angiectasis 1 (2%)
Basophilic Focus 1 (2%) 2 (3%) 1 (8%) 2 (3%) 1 (8%)
Clear Cell Focus 1 (2%)
Congestion 1 (2%)
Cyst 1 (2%) 1 (2%)
Eosinophilic Focus 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%)
Hyperplasia, Macrophage 1 (2%)
Infarct 5 (8%) 1 (8%) 1 (2%)
Inflammation, Suppurative 1 (8%)
Mixed Cell Focus 1 (2%) 1 (2%)
Thrombosis 3 (5%) 1 (2%)
Bile Duct, Cyst 1 (2%)
Hepatocyte, Cytomegaly 1 (2%) 1 (2%)
Hepatocyte, Cytoplasmic Alteration 1 (2%)
Hepatocyte, Hyperplasia 1 (2%)
Hepatocyte, Necrosis 4 (7%) 1 (13%) 1 (2%) 1 (8%) 4 (7%)
Mesentery (1) (1)
Hemorrhage 1 (100%)
Thrombosis 1 (100%)
Vein, Inflammation, Chronic 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/M3 O MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (52) (7) (58) (12) (60) (11)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Salivary Glands (55) (7) (60) (12) (60) (11)
Infiltration Cellular, Lymphocyte 1 (14%)
Stomach, Forestomach (52) (7) (57) (11) (60) (10)
Hyperkeratosis 1 (2%) 1 (2%)
Stomach, Glandular (53) (7) (57) (11) (60) (10)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (10%)
Tooth (2) (5) (4)
Dysplasia 2 (100%) 4 (80%) 1 (25%)
Peridontal Tissue, Inflammation, Chronic
Active 1 (25%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (55) (7) (60) (12) (60) (11)
Atrium, Thrombosis 1 (2%)
Ventricle, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (55) (7) (60) (12) (59) (11)
Cyst 1 (9%)
Hyperplasia 6 (11%) 4 (7%) 1 (8%) 6 (10%)
Bilateral, Hyperplasia 1 (2%)
Bilateral, Spindle Cell, Hyperplasia 1 (2%)
Spindle Cell, Hyperplasia 1 (2%) 2 (3%) 1 (2%)
Islets, Pancreatic (52) (7) (57) (12) (60) (11)
Hyperplasia 2 (4%) 2 (3%)
Parathyroid Gland (36) (6) (42) (9) (49) (8)
Cyst 1 (3%) 1 (2%)
Hyperplasia, Cystic 2 (5%)
Pituitary Gland (54) (7) (55) (12) (57) (11)
Pars Distalis, Cyst 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 2 (4%) 1 (2%)
Thyroid Gland (53) (7) (60) (12) (60) (11)
Hyperplasia, Cystic 13 (25%) 24 (40%) 3 (25%) 25 (42%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (9%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/M3 O MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1) (1) (3)
Abscess 1 (100%)
Inflammation, Suppurative 1 (33%)
Necrosis, Chronic 1 (33%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (54) (7) (60) (12) (60) (11)
Granuloma Sperm 1 (2%) 1 (2%)
Inflammation, Chronic 2 (4%)
Penis (7) (1) (8) (3) (6) (1)
Concretion 1 (14%) 3 (38%) 2 (67%) 4 (67%) 1 (100%)
Hemorrhage 1 (13%) 1 (17%)
Inflammation 1 (13%)
Inflammation, Chronic 1 (14%)
Inflammation, Suppurative 5 (71%) 1 (100%) 1 (13%) 1 (17%)
Mineralization 1 (13%)
Necrosis, Chronic 1 (13%) 1 (17%)
Preputial Gland (55) (7) (59) (15) (60) (12)
Atrophy 1 (7%) 4 (7%)
Concretion 1 (2%)
Ectasia 15 (27%) 5 (71%) 16 (27%) 6 (40%) 22 (37%) 6 (50%)
Hemorrhage 1 (2%)
Inflammation, Chronic 2 (4%) 7 (12%) 5 (8%)
Inflammation, Chronic Active 9 (16%) 10 (17%) 2 (13%) 6 (10%) 1 (8%)
Inflammation, Suppurative 14 (25%) 1 (14%) 6 (10%) 3 (20%) 12 (20%) 1 (8%)
Bilateral, Ectasia 22 (40%) 1 (14%) 30 (51%) 4 (27%) 34 (57%) 3 (25%)
Bilateral, Inflammation, Chronic Active 2 (3%) 1 (2%)
Bilateral, Inflammation, Suppurative 1 (8%)
Duct, Concretion 1 (8%)
Duct, Ectasia 3 (20%)
Prostate (51) (7) (55) (11) (57) (11)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 1 (2%) 2 (4%) 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Seminal Vesicle (53) (7) (59) (12) (60) (11)
Dilatation 1 (2%) 6 (10%) 2 (17%) 9 (15%) 2 (18%)
Inflammation, Chronic 1 (2%)
Testes (55) (7) (59) (12) (60) (11)
Atrophy 2 (3%) 1 (8%) 1 (2%)
Congestion 1 (8%)
Cyst 1 (2%)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/M3 O MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (54) (7) (59) (12) (60) (11)
Myeloid Cell, Hyperplasia 5 (9%) 9 (15%) 4 (33%) 13 (22%) 2 (18%)
Lymph Node (21) (2) (13) (6) (17) (3)
Iliac, Hyperplasia, Histiocytic 1 (5%)
Iliac, Hyperplasia, Lymphoid 8 (38%) 5 (38%) 3 (50%) 9 (53%) 2 (67%)
Iliac, Inflammation, Suppurative 1 (8%)
Iliac, Pigmentation 2 (15%) 2 (33%) 2 (12%) 1 (33%)
Inguinal, Hyperplasia 1 (5%)
Inguinal, Hyperplasia, Lymphoid 12 (57%) 1 (50%) 7 (54%) 2 (33%) 9 (53%) 2 (67%)
Inguinal, Pigmentation 1 (5%) 2 (15%)
Pancreatic, Hyperplasia, Lymphoid 1 (33%)
Pancreatic, Inflammation, Granulomatous 1 (5%) 1 (6%)
Renal, Hyperplasia, Histiocytic 1 (5%)
Renal, Hyperplasia, Lymphoid 1 (5%) 2 (100%) 2 (15%) 1 (33%)
Renal, Pigmentation 1 (8%) 1 (17%)
Lymph Node, Bronchial (43) (11) (50) (14) (56) (15)
Atrophy 1 (2%)
Congestion 1 (2%) 1 (2%)
Edema 1 (2%)
Hyperplasia, Lymphoid 5 (12%) 16 (32%) 2 (14%) 28 (50%) 3 (20%)
Inflammation, Chronic Active 1 (7%)
Inflammation, Granulomatous 1 (2%)
Pigmentation 49 (98%) 12 (86%) 56 (100%) 15 (100%)
Lymph Node, Mandibular (45) (7) (51) (11) (57) (11)
Hyperplasia, Histiocytic 1 (2%)
Hyperplasia, Lymphoid 3 (7%) 3 (6%) 3 (5%) 1 (9%)
Lymph Node, Mesenteric (43) (7) (48) (12) (52) (9)
Congestion 3 (7%) 1 (14%) 11 (23%) 2 (17%) 12 (23%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Lymphoid 3 (7%) 2 (4%) 2 (17%) 3 (6%) 2 (22%)
Hyperplasia, Macrophage 1 (2%)
Inflammation, Suppurative 3 (7%) 1 (14%) 1 (2%) 2 (4%)
Pigmentation 1 (2%)
Lymph Node, Mediastinal (16) (8) (19) (2) (19) (8)
Hyperplasia, Lymphoid 1 (6%)
Inflammation, Chronic 1 (13%)
Pigmentation 3 (16%) 1 (5%)
Spleen (54) (7) (60) (12) (60) (11)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 16 (30%) 1 (14%) 12 (20%) 2 (17%) 11 (18%) 2 (18%)
Hyperplasia, Lymphoid 2 (4%) 2 (29%) 4 (7%) 1 (8%) 5 (8%) 2 (18%)
Thymus (43) (7) (49) (8) (47) (10)
Atrophy 1 (2%) 1 (2%)
Cyst 1 (2%)
Inflammation, Granulomatous 1 (10%)
Pigmentation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/M3 O MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (16) (18) (5) (22) (2)
Alopecia 1 (6%) 1 (6%)
Inflammation, Chronic 1 (6%)
Inflammation, Chronic Active 1 (6%) 2 (11%)
Inflammation, Suppurative 13 (81%) 8 (44%) 3 (60%) 14 (64%) 2 (100%)
Necrosis 1 (6%) 1 (20%) 1 (5%)
Prepuce, Inflammation, Chronic Active 1 (5%)
Prepuce, Inflammation, Suppurative 4 (22%) 1 (20%) 3 (14%)
Prepuce, Necrosis 1 (5%)
Subcutaneous Tissue, Edema 1 (6%) 1 (20%)
Subcutaneous Tissue, Fibrosis 1 (6%)
Subcutaneous Tissue, Hemorrhage 1 (6%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (5%)
Subcutaneous Tissue, Inflammation,
Suppurative 1 (5%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (55) (7) (60) (12) (60) (11)
Developmental Malformation 1 (2%)
Fracture Healed 2 (4%) 1 (8%)
Hemorrhage 1 (2%)
Hyperostosis 2 (4%) 3 (5%) 1 (9%)
Vertebra, Inflammation, Suppurative 1 (2%)
Skeletal Muscle (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (55) (7) (60) (12) (60) (11)
Pons, Demyelination 2 (3%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (55) (12) (60) (17) (60) (16)
Hemorrhage 1 (2%) 2 (3%)
Hyperplasia, Macrophage 1 (2%)
Inflammation, Chronic 1 (8%) 20 (33%) 3 (18%) 32 (53%) 7 (44%)
Thrombosis 2 (3%)
Alveolar Epithelium, Hyperplasia 23 (38%) 2 (12%) 37 (62%) 3 (19%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%) 1 (8%) 1 (2%) 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/M3 O MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolus, Pigmentation 58 (97%) 17 (100%) 60 (100%) 16 (100%)
Alveolus, Proteinosis 11 (18%) 1 (6%) 19 (32%) 4 (25%)
Pleura, Fibrosis 1 (6%)
Nose (53) (12) (59) (17) (60) (16)
Inflammation, Suppurative 2 (3%) 1 (2%)
Olfactory Epithelium, Degeneration 3 (5%) 1 (6%) 1 (2%) 1 (6%)
Olfactory Epithelium, Inflammation,
Suppurative 2 (3%)
Respiratory Epithelium, Degeneration 2 (4%) 2 (3%) 1 (6%) 3 (5%) 1 (6%)
Respiratory Epithelium, Inflammation,
Suppurative 6 (11%) 7 (12%) 2 (12%) 9 (15%)
Respiratory Epithelium, Metaplasia, Squamous 2 (4%) 6 (10%) 1 (6%) 8 (13%)
Vomeronasal Organ, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (55) (12) (60) (17) (60) (16)
Atrophy 1 (8%)
Fibrosis 1 (2%)
Infiltration Cellular, Lymphocyte 1 (6%) 1 (6%)
Inflammation, Chronic 2 (3%)
Inflammation, Chronic Active 1 (2%) 6 (10%)
Inflammation, Suppurative 1 (2%) 3 (5%) 1 (6%)
Mineralization 1 (2%) 1 (2%)
Necrosis 1 (2%)
Nephropathy 1 (2%) 1 (2%) 2 (3%) 1 (6%)
Bilateral, Inflammation, Suppurative 1 (8%)
Bilateral, Papilla, Inflammation, Suppurative 1 (2%)
Bilateral, Pelvis, Dilatation 1 (2%)
Cortex, Cyst 1 (2%) 1 (2%) 2 (3%)
Cortex, Fibrosis 1 (2%)
Cortex, Inflammation, Chronic 1 (2%)
Pelvis, Dilatation 8 (15%) 1 (8%) 5 (8%) 1 (6%) 7 (12%) 2 (13%)
Pelvis, Inflammation, Chronic 1 (2%)
Pelvis, Inflammation, Chronic Active 1 (2%)
Pelvis, Inflammation, Suppurative 2 (4%) 1 (2%)
Renal Tubule, Mineralization 2 (3%)
Ureter (2)
Inflammation, Suppurative 1 (50%)
Urethra (2) (4) (5)
Calculus Micro Observation Only 1 (50%) 3 (75%) 4 (80%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/M3 O MG/M3 1.25MGM3 1.25MGM3 2.5MG/M3 2.5MG/M3
LUNGTX LUNGTX LUNGTX
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Concretion 1 (50%) 1 (25%) 1 (20%)
Urinary Bladder (52) (7) (56) (12) (59) (10)
Calculus Micro Observation Only 1 (2%) 1 (14%) 3 (5%) 3 (5%)
Crystals 1 (2%)
Hemorrhage 1 (2%)
Inflammation 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 1 (2%) 1 (10%)
Inflammation, Suppurative 2 (4%) 5 (9%) 2 (3%)
Transitional Epithelium, Hyperplasia 1 (14%)
Transitional Epithelium, Metaplasia, Squamous 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 5.0MG/M3 5.0MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 20
Scheduled Sacrifice 10
Early Deaths
Moribund Sacrifice 22 7
Natural Death 15 2
Survivors
Terminal Sacrifice 23
Terminal Sacrifice 1
Animals Examined Microscopically 60 19
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (50) (13)
Inflammation, Chronic 1 (2%)
Intestine Large, Cecum (52) (13)
Hyperplasia, Lymphoid 2 (4%)
Liver (60) (14)
Abscess 1 (2%)
Basophilic Focus 1 (2%)
Developmental Malformation 1 (2%)
Eosinophilic Focus 1 (2%) 1 (7%)
Fatty Change 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Infarct 4 (7%)
Hepatocyte, Hyperplasia 1 (2%) 1 (7%)
Hepatocyte, Necrosis 4 (7%)
Pancreas (59) (14)
Cyst 1 (2%)
Stomach, Forestomach (58) (14)
Hyperkeratosis 1 (2%)
Stomach, Glandular (58) (14)
Inflammation, Suppurative 1 (2%)
Tooth (1)
Dysplasia 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (14)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 5.0MG/M3 5.0MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (14)
Cyst 1 (2%)
Hyperplasia 2 (3%)
Pituitary Gland (57) (14)
Pars Distalis, Hyperplasia 1 (2%)
Thyroid Gland (60) (14)
Hyperplasia, Cystic 25 (42%) 2 (14%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (2)
Hemorrhage 1 (50%)
Inflammation, Suppurative 1 (50%)
Necrosis 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (59) (14)
Inflammation, Chronic 2 (3%)
Inflammation, Chronic Active 1 (7%)
Inflammation, Suppurative 1 (2%)
Penis (10) (3)
Concretion 4 (40%) 1 (33%)
Inflammation 1 (10%)
Inflammation, Suppurative 4 (40%) 2 (67%)
Preputial Gland (60) (16)
Atrophy 2 (3%)
Ectasia 19 (32%) 3 (19%)
Inflammation, Chronic 7 (12%) 2 (13%)
Inflammation, Chronic Active 2 (3%)
Inflammation, Suppurative 9 (15%) 2 (13%)
Bilateral, Ectasia 36 (60%) 5 (31%)
Duct, Concretion 2 (13%)
Prostate (57) (13)
Inflammation, Suppurative 1 (2%)
Seminal Vesicle (60) (13)
Cyst 1 (2%)
Dilatation 6 (10%) 4 (31%)
Testes (60) (14)
Atrophy 1 (2%)
Bilateral, Atrophy 1 (2%)
Germinal Epithelium, Degeneration 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 20
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 5.0MG/M3 5.0MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (14)
Erythroid Cell, Hyperplasia 1 (2%)
Myeloid Cell, Hyperplasia 10 (17%) 3 (21%)
Myeloid Cell, Inflammation 1 (2%)
Lymph Node (12) (4)
Iliac, Hyperplasia, Lymphoid 8 (67%)
Iliac, Pigmentation 2 (17%)
Inguinal, Hyperplasia, Lymphoid 6 (50%) 3 (75%)
Lymph Node, Bronchial (55) (16)
Congestion 1 (2%)
Edema 1 (2%)
Hyperplasia, Lymphoid 32 (58%) 5 (31%)
Pigmentation 53 (96%) 16 (100%)
Lymph Node, Mandibular (52) (13)
Hyperplasia, Lymphoid 2 (4%)
Lymph Node, Mesenteric (54) (14)
Congestion 6 (11%)
Hematopoietic Cell Proliferation 2 (4%) 1 (7%)
Hyperplasia, Lymphoid 3 (6%)
Inflammation, Suppurative 1 (2%)
Lymph Node, Mediastinal (20) (9)
Congestion 2 (10%)
Pigmentation 1 (5%)
Spleen (60) (14)
Hematopoietic Cell Proliferation 13 (22%) 4 (29%)
Hyperplasia, Lymphoid 4 (7%)
Thrombosis 2 (3%)
Thymus (51) (12)
Atrophy 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (22) (5)
Alopecia 1 (20%)
Cyst Epithelial Inclusion 1 (5%)
Inflammation, Chronic Active 1 (20%)
Inflammation, Suppurative 11 (50%) 2 (40%)
Necrosis 1 (5%)
Prepuce, Inflammation 1 (5%)
Prepuce, Inflammation, Suppurative 3 (14%) 1 (20%)
Subcutaneous Tissue, Fibrosis 1 (5%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 21
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 5.0MG/M3 5.0MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (59) (14)
Fracture Healed 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (19)
Congestion 1 (5%)
Fibrosis 1 (2%)
Inflammation, Chronic 48 (80%) 14 (74%)
Alveolar Epithelium, Hyperplasia 35 (58%) 7 (37%)
Alveolus, Pigmentation 60 (100%) 18 (95%)
Alveolus, Proteinosis 37 (62%) 9 (47%)
Nose (58) (19)
Olfactory Epithelium, Degeneration 1 (2%)
Respiratory Epithelium, Degeneration 1 (2%)
Respiratory Epithelium, Inflammation,
Suppurative 7 (12%)
Respiratory Epithelium, Metaplasia, Squamous 2 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (3)
Hyperplasia 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (19)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 5 (8%) 1 (5%)
Nephropathy 1 (2%)
Pelvis, Dilatation 4 (7%) 1 (5%)
Pelvis, Hyperplasia, Squamous 1 (2%)
Pelvis, Inflammation, Chronic Active 1 (2%)
Pelvis, Inflammation, Suppurative 1 (5%)
Ureter (3) (1)
Concretion 2 (67%)
Inflammation, Chronic Active 1 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 22
NTP Experiment-Test: 05123-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL OXIDE Date: 05/20/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 05:20:49
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 5.0MG/M3 5.0MG/M3
LUNGTX
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Suppurative 1 (100%)
Urethra (11) (1)
Calculus Micro Observation Only 7 (64%) 1 (100%)
Concretion 4 (36%)
Urinary Bladder (57) (14)
Calculus Gross Observation 1 (2%)
Calculus Micro Observation Only 1 (2%)
Inflammation, Chronic Active 1 (2%)
Inflammation, Suppurative 3 (5%) 1 (7%)
Transitional Epithelium, Hyperplasia 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 23
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