TDMS Study 05123-06 Pathology Tables
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
LUNG TOX CORE ANIMALS
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 1313-99-1
Lock Date: 04/19/94
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25026 Other
25006 Terminal Sacrifice 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Exclude 001 0 MG/M3
Exclude 002 0 MG/M3
Exclude 005 1.25MGM3
Exclude 006 1.25MGM3
Exclude 010 2.5MG/M3
Exclude 013 5.0MG/M3
Exclude 014 5.0MG/M3
Exclude 009 2.5MG/M3
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 7| 0| 0| 0| 7| | |
DAY ON TEST | 3| 2| 3| 3| 3| 3| 9| 1| 2| 2| | |
| 6| 9| 0| 0| 3| 2| 2| 1| 4| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | A |
0 MG/M3 | 8| 8| 8| 9| 9| 0| 0| 2| 3| 5| | L |
LUNGTX | 4| 7| 8| 2| 8| 4| 8| 0| 2| 7| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 4 |
__________________________________________________________________________|____________|
Gallbladder | + + + A | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A | 3 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A | 3 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A | 3 |
__________________________________________________________________________|____________|
Liver | + + + + | 4 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 4 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 4 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 4 |
__________________________________________________________________________|____________|
Adrenal Medulla | + I + M | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 4 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M M | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + M | 3 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + + | 3 |
__________________________________________________________________________|____________|
Ovary | + + + + | 4 |
Teratoma Benign | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M M | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + M M M | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 2
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 2| 7| 7| 7| 7| 0| 0| 0| 7| | |
DAY ON TEST | 3| 2| 3| 3| 3| 3| 9| 1| 2| 2| | |
| 6| 9| 0| 0| 3| 2| 2| 1| 4| 9| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | A |
0 MG/M3 | 8| 8| 8| 9| 9| 0| 0| 2| 3| 5| | L |
LUNGTX | 4| 7| 8| 2| 8| 4| 8| 0| 2| 7| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M | |
__________________________________________________________________________|____________|
Spleen | + + + + | 4 |
__________________________________________________________________________|____________|
Thymus | + M + + | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + | 4 |
__________________________________________________________________________|____________|
Lung | + + + + | 4 |
__________________________________________________________________________|____________|
Nose | + A + + | 3 |
__________________________________________________________________________|____________|
Trachea | + + + I | 3 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + A | 3 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 3
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 5| 6| 5| 7| 7| 6| 0| 7| 7| 1| | |
DAY ON TEST | 9| 5| 9| 3| 3| 2| 4| 3| 2| 6| | |
| 7| 7| 3| 3| 3| 6| 6| 2| 9| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| | A |
1.25MGM3 | 4| 6| 6| 6| 7| 8| 0| 0| 1| 2| | L |
LUNGTX | 7| 0| 4| 8| 4| 5| 8| 9| 5| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 6 |
__________________________________________________________________________|____________|
Gallbladder | A A + + A + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A A + + A + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A M + + A + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A A + + A + | 3 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + A + | 4 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A A + + A + | 3 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A A + + A + | 3 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 6 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 6 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 6 |
__________________________________________________________________________|____________|
Stomach, Forestomach | A + + + A + | 4 |
__________________________________________________________________________|____________|
Stomach, Glandular | A + + + A + | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 6 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 6 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 6 |
Pars Distalis, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + | 6 |
__________________________________________________________________________|____________|
Ovary | + + + + + + | 6 |
Teratoma Benign | X | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + | 6 |
Hemangiosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 6 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 4
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 5| 6| 5| 7| 7| 6| 0| 7| 7| 1| | |
DAY ON TEST | 9| 5| 9| 3| 3| 2| 4| 3| 2| 6| | |
| 7| 7| 3| 3| 3| 6| 6| 2| 9| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| | A |
1.25MGM3 | 4| 6| 6| 6| 7| 8| 0| 0| 1| 2| | L |
LUNGTX | 7| 0| 4| 8| 4| 5| 8| 9| 5| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Iliac, Lymphoma Malignant | X | 1 |
Renal, Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M | 5 |
Sarcoma, Metastatic, Skin | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M I M M | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 6 |
__________________________________________________________________________|____________|
Thymus | + + + + + + | 6 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + | 6 |
__________________________________________________________________________|____________|
Skin | + + | 2 |
Sarcoma | X | 1 |
Pinna, Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 6 |
__________________________________________________________________________|____________|
Lung | + + + + + + | 6 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 1 |
__________________________________________________________________________|____________|
Nose | A + + + + + | 5 |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 6 |
__________________________________________________________________________|____________|
Urinary Bladder | A + + + A + | 4 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 5| 6| 5| 7| 7| 6| 0| 7| 7| 1| | |
DAY ON TEST | 9| 5| 9| 3| 3| 2| 4| 3| 2| 6| | |
| 7| 7| 3| 3| 3| 6| 6| 2| 9| 2| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| | A |
1.25MGM3 | 4| 6| 6| 6| 7| 8| 0| 0| 1| 2| | L |
LUNGTX | 7| 0| 4| 8| 4| 5| 8| 9| 5| 0| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 0| 7| 5| 6| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 6| 7| 3| 7| 3| 3| 3| 3| | |
| 6| 2| 6| 0| 1| 6| 0| 1| 2| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.5MG/M3 | 1| 1| 1| 3| 4| 4| 5| 5| 6| 7| | L |
LUNGTX | 0| 1| 4| 3| 5| 9| 1| 4| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + | 4 |
__________________________________________________________________________|____________|
Gallbladder | A + + + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + | 3 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + | 3 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + | 3 |
__________________________________________________________________________|____________|
Liver | + + + + | 4 |
Hepatocellular Carcinoma | X X | 2 |
Hepatocellular Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 4 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + | 4 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 4 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 4 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + | 4 |
__________________________________________________________________________|____________|
Ovary | + + M + | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 4 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + + | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 0| 7| 5| 6| 7| 6| 7| 7| 7| 7| | |
DAY ON TEST | 3| 3| 6| 7| 3| 7| 3| 3| 3| 3| | |
| 6| 2| 6| 0| 1| 6| 0| 1| 2| 1| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.5MG/M3 | 1| 1| 1| 3| 4| 4| 5| 5| 6| 7| | L |
LUNGTX | 0| 1| 4| 3| 5| 9| 1| 4| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M + | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + | 4 |
__________________________________________________________________________|____________|
Thymus | + + M + | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + | 4 |
__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + | 4 |
__________________________________________________________________________|____________|
Lung | + + + + | 4 |
__________________________________________________________________________|____________|
Nose | A + + + | 3 |
__________________________________________________________________________|____________|
Trachea | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 4 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 6| 4| 6| 7| | |
DAY ON TEST | 3| 4| 6| 3| 3| 3| 9| 9| 5| 3| | |
| 0| 4| 9| 3| 0| 1| 6| 8| 8| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | A |
5.0MG/M3 | 8| 9| 9| 9| 0| 0| 1| 2| 2| 2| | L |
LUNGTX | 0| 1| 5| 8| 1| 7| 7| 0| 1| 3| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
__________________________________________________________________________|____________|
Gallbladder | + + + A + | 4 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + A + | 3 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + | 4 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + | 4 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + | 4 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + | 4 |
__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Hepatocellular Carcinoma | X | 1 |
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
Squamous Cell Papilloma | X | 1 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Hemangiosarcoma, Metastatic | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Ovary | + + + + + | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 6| 4| 7| 7| 7| 6| 4| 6| 7| | |
DAY ON TEST | 3| 4| 6| 3| 3| 3| 9| 9| 5| 3| | |
| 0| 4| 9| 3| 0| 1| 6| 8| 8| 6| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | A |
5.0MG/M3 | 8| 9| 9| 9| 0| 0| 1| 2| 2| 2| | L |
LUNGTX | 0| 1| 5| 8| 1| 7| 7| 0| 1| 3| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
Hemangiosarcoma, Metastatic | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
Hemangiosarcoma | X X | 2 |
__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Skin | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + | 5 |
__________________________________________________________________________|____________|
Lung | + + + + + | 5 |
Alveolar/Bronchiolar Carcinoma | X X | 2 |
Hepatocellular Carcinoma, Metastatic | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + | 5 |
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 7| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 3| 3| 9| 3| 7| 7| 7| 7| 7| 7| | |
| 7| 9| 3| 7| 7| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
O MG/M3 | 0| 2| 3| 5| 7| 7| 7| 7| 7| 8| | L |
LUNGTX | 2| 7| 9| 1| 2| 3| 4| 6| 7| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Gallbladder | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 2 |
__________________________________________________________________________|____________|
Liver | + + | 2 |
__________________________________________________________________________|____________|
Pancreas | + + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + | 2 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Hemangiosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + | 2 |
__________________________________________________________________________|____________|
Preputial Gland | + + | 2 |
__________________________________________________________________________|____________|
Prostate | + + | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + | 2 |
__________________________________________________________________________|____________|
Testes | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
Hemangiosarcoma, Metastatic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 6| 7| 5| 7| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 3| 3| 9| 3| 7| 7| 7| 7| 7| 7| | |
| 7| 9| 3| 7| 7| 7| 7| 7| 7| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
O MG/M3 | 0| 2| 3| 5| 7| 7| 7| 7| 7| 8| | L |
LUNGTX | 2| 7| 9| 1| 2| 3| 4| 6| 7| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + | 2 |
__________________________________________________________________________|____________|
Spleen | + + | 2 |
__________________________________________________________________________|____________|
Thymus | + + | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
Hemangiosarcoma, Metastatic | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + | 2 |
__________________________________________________________________________|____________|
Lung | + + | 2 |
__________________________________________________________________________|____________|
Nose | + + | 2 |
__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 5| 7| 7| 7| 5| 5| 7| | |
DAY ON TEST | 3| 7| 5| 0| 1| 3| 3| 6| 3| 2| | |
| 7| 6| 7| 1| 7| 7| 7| 7| 9| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
1.25MGM3 | 7| 7| 8| 8| 9| 9| 0| 0| 1| 3| | L |
LUNGTX | 0| 2| 2| 5| 4| 8| 8| 9| 3| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Gallbladder | M + + + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + M + M + + | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + | 6 |
__________________________________________________________________________|____________|
Liver | + + + + + + + | 7 |
Hepatocellular Carcinoma | X X | 2 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 6 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + | 6 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + | 7 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Penis | + + + | 3 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Prostate | + + + + M + + | 6 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Testes | + + + + + + + | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 5| 7| 7| 7| 5| 5| 7| | |
DAY ON TEST | 3| 7| 5| 0| 1| 3| 3| 6| 3| 2| | |
| 7| 6| 7| 1| 7| 7| 7| 7| 9| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
1.25MGM3 | 7| 7| 8| 8| 9| 9| 0| 0| 1| 3| | L |
LUNGTX | 0| 2| 2| 5| 4| 8| 8| 9| 3| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 5 |
Iliac, Lymphoma Malignant | X | 1 |
Inguinal, Lymphoma Malignant | X | 1 |
Renal, Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + | 6 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + | 6 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 7 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M M | |
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 7 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Thymus | M + + I + + I | 4 |
Lymphoma Malignant | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + I + + + | 6 |
__________________________________________________________________________|____________|
Lung | + + + + + + + | 7 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Hepatocellular Carcinoma, Metastatic | X | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + | 7 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 7| 6| 5| 5| 7| 7| 7| 5| 5| 7| | |
DAY ON TEST | 3| 7| 5| 0| 1| 3| 3| 6| 3| 2| | |
| 7| 6| 7| 1| 7| 7| 7| 7| 9| 8| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | A |
1.25MGM3 | 7| 7| 8| 8| 9| 9| 0| 0| 1| 3| | L |
LUNGTX | 0| 2| 2| 5| 4| 8| 8| 9| 3| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + | 7 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 7 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + | 7 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 4| 2| 3| 7| 6| 7| | |
DAY ON TEST | 3| 9| 3| 3| 8| 4| 6| 3| 7| 3| | |
| 9| 4| 8| 9| 2| 5| 8| 7| 9| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5MG/M3 | 2| 3| 4| 6| 6| 7| 7| 7| 8| 9| | L |
LUNGTX | 3| 9| 1| 4| 9| 2| 3| 6| 1| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 6 |
__________________________________________________________________________|____________|
Gallbladder | + A + + M + | 4 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A A + | 4 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A A + | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A A + | 4 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + A A + | 3 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + A A + | 3 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A A + | 3 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 6 |
Hepatocellular Carcinoma, Multiple | X | 1 |
Hepatocellular Adenoma, Multiple | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 6 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 6 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + A + + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 6 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 6 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M M + | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 6 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 6 |
Follicular Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 6 |
__________________________________________________________________________|____________|
Penis | + | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 6 |
__________________________________________________________________________|____________|
Prostate | + + + + + + | 6 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 6 |
__________________________________________________________________________|____________|
Testes | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 5| 6| 7| 7| 4| 2| 3| 7| 6| 7| | |
DAY ON TEST | 3| 9| 3| 3| 8| 4| 6| 3| 7| 3| | |
| 9| 4| 8| 9| 2| 5| 8| 7| 9| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
2.5MG/M3 | 2| 3| 4| 6| 6| 7| 7| 7| 8| 9| | L |
LUNGTX | 3| 9| 1| 4| 9| 2| 3| 6| 1| 9| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 6 |
__________________________________________________________________________|____________|
Lymph Node | + + + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + M + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M M + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M M M M | 2 |
__________________________________________________________________________|____________|
Spleen | + + + + + + | 6 |
__________________________________________________________________________|____________|
Thymus | + M + + + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Skin | + + | 2 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + | 6 |
__________________________________________________________________________|____________|
Lung | + + + + + + | 6 |
__________________________________________________________________________|____________|
Nose | + + + + + + | 6 |
__________________________________________________________________________|____________|
Trachea | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + | 6 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + | 6 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 6| 0| 6| 6| 5| 4| 7| 5| 6| 3| | |
DAY ON TEST | 9| 2| 1| 7| 8| 3| 3| 7| 7| 1| | |
| 8| 1| 5| 0| 0| 1| 7| 1| 6| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| | A |
5.0MG/M3 | 8| 9| 0| 3| 3| 3| 3| 4| 4| 5| | L |
LUNGTX | 2| 9| 7| 1| 2| 4| 5| 1| 5| 7| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Gallbladder | + M + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + + M + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + M + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + | 8 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + | 8 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 9 |
Hepatocellular Adenoma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + M | 8 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + M M | 6 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + + | 2 |
Sarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Penis | + + + | 3 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + M | 8 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 6| 0| 6| 6| 5| 4| 7| 5| 6| 3| | |
DAY ON TEST | 9| 2| 1| 7| 8| 3| 3| 7| 7| 1| | |
| 8| 1| 5| 0| 0| 1| 7| 1| 6| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| | A |
5.0MG/M3 | 8| 9| 0| 3| 3| 3| 3| 4| 4| 5| | L |
LUNGTX | 2| 9| 7| 1| 2| 4| 5| 1| 5| 7| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Lymph Node | + + + + | 4 |
Iliac, Lymphoma Malignant | X | 1 |
Inguinal, Lymphoma Malignant | X | 1 |
Renal, Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + + M | 7 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + | 8 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 9 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + M + M + + M | 5 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 9 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Thymus | + + + + + + M M + | 7 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 9 |
Alveolar/Bronchiolar Adenoma | X X | 2 |
Alveolar/Bronchiolar Carcinoma | X | 1 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 9 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05123-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC NICKEL OXIDE Date: 04/08/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:10:21
__________________________________________________________________________________________________________________________________
| 6| 0| 6| 6| 5| 4| 7| 5| 6| 3| | |
DAY ON TEST | 9| 2| 1| 7| 8| 3| 3| 7| 7| 1| | |
| 8| 1| 5| 0| 0| 1| 7| 1| 6| 7| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| | A |
5.0MG/M3 | 8| 9| 0| 3| 3| 3| 3| 4| 4| 5| | L |
LUNGTX | 2| 9| 7| 1| 2| 4| 5| 1| 5| 7| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 9 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________|____________|
Ureter | + | 1 |
__________________________________________________________________________|____________|
Urethra | + | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 9 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + | 9 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
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---------- END OF REPORT ----------
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